| de-facto | maybe its better visible with solid white background | 01:45 |
|---|---|---|
| kara[m] | covid is common in the sense that it's a common cause of death 2020 | 01:45 |
| de-facto | %title https://imgur.com/a/1HLgpdR https://i.imgur.com/cxnXQlM.png | 01:45 |
| Brainstorm | de-facto: From imgur.com: COVID19 USA Reproduction Rt from 2020-10-01 linear approx. - Album on Imgur | 01:45 |
| de-facto | kara[m], yeah unfortunately since its a worldwide pandemic and it getting much worse in the winter | 01:46 |
| de-facto | as it seems to be expected by that paper | 01:46 |
| de-facto | so it kinda makes sense that Rt values are on the raise | 01:46 |
| Brainstorm | New from "Cluster 5" on Wikipedia: Ypna: /* Background */ +image: Background: +image ← Previous revision Revision as of 00:43, 16 November 2020 Line 8: Line 8: == Background == == Background == + [[File:American Mink, Centre Island, Toronto, ON (9374114650).jpg|thumb|American mink (''[[Neovison vison]]'')]] + Denmark is the largest producer of mink [... want %more?] → https://is.gd/74bzDF | 01:48 |
| kara[m] | tt yall later | 01:51 |
| Brainstorm | New from "Cluster 5" on Wikipedia: Ypna: /* References */ +navbox: References: +navbox ← Previous revision Revision as of 00:52, 16 November 2020 Line 25: Line 25: {{Reflist}} {{Reflist}} {{Use dmy dates|date=November 2020}} {{Use dmy dates|date=November 2020}} + {{COVID-19}} − [[Category:COVID-19 pandemic in Denmark]] [[Category:COVID-19 pandemic [... want %more?] → https://is.gd/74bzDF | 01:57 |
| Brainstorm | New from BBC Health: Covid vaccine: Major new trial starts in UK: It comes a week after preliminary results showed another vaccine offered 90% protection. → https://is.gd/S0hm6d | 02:16 |
| ryouma | has anybody looked at whether places that were bad before are bad? i.e. badness is associated with a place compared to new places getting bad. | 02:19 |
| de-facto | ryouma, id assume some alternation effect, e.g. hard hit places being more careful and lucky places caring less about containment, apart from biological effects like seroprevalence (antibodies) dampening second time dynamics for places that were hit hard first time | 02:39 |
| dTal | de-facto: there does seem to be an oscillation effect, where places that lock down harder get bored of lockdown and rebound worse | 02:44 |
| LjL | ryouma, de-facto: i suspect the dynamics are complicated. in Italy, i see a shift from countryside (first wave) to cities (second wave), and within Lombardy the places hit are different, with the places that were spared during the first wave being hit during the second, and vice versa. so okay, that seems very much "the reverse of the first time", but, Lombardy as a whole is still by far the most hit place in both waves. | 02:44 |
| LjL | maybe we can explain that as the LjL effect | 02:44 |
| LjL | which posits that wherever LjL is things will suck | 02:44 |
| de-facto | here its also alternating, we were below average prevalence of the neighboring regions in first wave, now its the opposite and our city got above average prevalence | 02:46 |
| de-facto | maybe peoble where thinking, hey we dont have to take so much care, our city is safe due to some reason, idk | 02:46 |
| de-facto | but idk i guess NYC will take much more care this time | 02:47 |
| de-facto | they know how bad it can get there | 02:47 |
| de-facto | thats just a guess though | 02:48 |
| Brainstorm | New from r/WorldNews: worldnews: Boris Johnson self-isolating AGAIN after MP tests positive for COVID-19 → https://is.gd/5DfFoX | 02:53 |
| LjL | tinwhiskers, sorry i'm just very (extremely?) nervous and the people on reddit with their "naaah" "naaah" "naaah" amplified the effect, i know you aren't ruling it out, i just think i'm seeing some general bias and counter it with more nervous counter-bias than it warrants | 02:55 |
| LjL | and i think ryouma shouldn't have just jumped in like that with "........... i don't buy it", tbh | 02:56 |
| LjL | low effort way to rile me up further. i know articulating your thoughts further can be hard for you but it is frustrating when you are trying to explain your point of view with lots of typing and someone is just like "i don't buy it" | 02:57 |
| dTal | i don't buy it | 03:17 |
| dTal | ...wh-wh-where did you get all that... | 03:24 |
| Brainstorm | New from NPR: U.S. Hits 11 Million Coronavirus Cases, Adding 1 Million In A Week: More than 11 million confirmed coronavirus cases have been recorded in the U.S., according Johns Hopkins University. The country recorded 166,555 new cases in the last day and 1,266 new deaths. → https://is.gd/VKDUAR | 03:30 |
| Brainstorm | New from The Indian Express: World: Boris Johnson self-isolating after contact with COVID-positive MP → https://is.gd/nd0QeK | 03:49 |
| ryouma | what precisely did you think i did not buy? --- 18:56 <LjL> and i think ryouma shouldn't have just jumped in like that with "........... i don't buy it", tbh | 03:54 |
| LjL | ryouma, that the Italian (and other European, presumably) studies about presence of virus in sewage and now antibodies in human blood prior to 2020 could indicate the virus was actually there as opposed to some error in the studies | 03:55 |
| ryouma | nope | 03:55 |
| LjL | dTal, oh the sewage spills up just about every time there is a storm, i'd just have to ask the ground floor neighbors for some of theirs! | 03:56 |
| ryouma | i said what i didn't buy. --- 14:36 <ryouma> the one we know about enters coutnries and immediately explodes. or can. | 03:57 |
| LjL | ryouma, so you don't buy *one possible explanation* of that? | 03:57 |
| LjL | but i'm still not sure this makes sense | 03:57 |
| ryouma | i didn't say that either | 03:57 |
| LjL | the one we know about immediately explodes... unless we *don't notice* that it doesn't immediately explode and stays around for a while instead | 03:58 |
| LjL | that's kind of the whole thing that finding it prior to the "explosion" suggests | 03:58 |
| LjL | okay i'll stop playing guessing game then | 03:59 |
| ryouma | i did not me3an to diss you or reject your overall hypothesis (i am not saying that it is your belief either just calling it a hypothesis) | 03:59 |
| ryouma | do you have the scrollback for after you left? | 03:59 |
| ryouma | it will clarify | 03:59 |
| de-facto | if it had the same properties than the strain that exploded it should be expected to have done the same, yet its not clear if it already had such virulent properties, hence i am curious about a full sequence including s-protein | 04:00 |
| LjL | i can grab it from Matrix but maybe it's best if we just forget this happened for now, i am still feeling kinda cranky tbh | 04:00 |
| de-facto | i am also not rejecting anything, i am just trying understand it, actually its quite interesting hence id like to see more data about it | 04:01 |
| ryouma | same here | 04:01 |
| ryouma | if you mean doctors and reporting syustems missing diseases i agreed with you that that is a strong possibility; don't know if it /was the case/, but i probably have more belief in the "missing diseases" thing than you do. --- 19:57 <LjL> ryouma, so you don't buy *one possible explanation* of that? | 04:04 |
| LjL | the problem with that is that if it's as "explosive" as de-facto and many others take for granted, even with a really shitty reporting system like we probably have, i think we'd have noticed | 04:05 |
| ryouma | smiley goes there :) | 04:05 |
| ryouma | and stop reading reddit when it gets that bad! | 04:05 |
| LjL | so yes, it could be that the reporting system missed it, and that's a hypothesis that's made stronger by the fact that, well, doctors *did* say there were many unexplained pneumonias in hindsight | 04:06 |
| de-facto | well yeah unless it was not so virulent back then and first had to mutate to become "explosive" | 04:06 |
| ryouma | well you know the facts more than i do | 04:06 |
| LjL | but for that to be a possibility i think it also has to mean that the disease had a lower R than at its worst times | 04:06 |
| ryouma | especially given a naive population | 04:06 |
| ryouma | in the technical not personality sense | 04:07 |
| LjL | de-facto, what if mutation is not the only option to make it less "explosive"? again, we don't understand why it "explodes" after keeping relatively quiet for a while. so whatever the reason it is that it did it now, could have been the reason it did it before. | 04:07 |
| LjL | weather playing a role, for instance | 04:07 |
| LjL | or even pollution | 04:08 |
| LjL | that was being rumored here for a while | 04:08 |
| LjL | and it's not completely made up because they did find viral RNA on particular matter when they looked for it | 04:08 |
| ryouma | i hope you read the scrollback sometimes just for clarity | 04:08 |
| LjL | so it's not implausible that particulate matter could be a vector to make the virus airborne | 04:08 |
| de-facto | yes thats what i meant earlier, if it was exactly the same strain and still did not explode such information would be even more valuable because it could be employed in containment strategies | 04:09 |
| LjL | yes | 04:09 |
| ryouma | doing pcr (at all that is) is not rocket science, i hear. so why didn't they? | 04:09 |
| LjL | which is why i insist on this thing, and i get annoyed that it is discounted... because it doesn't have to be about "OMG it didn't originate in China!!!1", it's about understanding how it WORKS | 04:09 |
| ryouma | i think we all agree | 04:10 |
| de-facto | ryouma, because first the virus has to be suspected, then isolated from patients, then sequenced and primers designed for a PCR test | 04:10 |
| LjL | ryouma, they did on the sewage. i don't know why they didn't in this latest study, but if the blood is full of antibodies and has sat there for ages, do you think the PCR will actually pick up anything? | 04:10 |
| LjL | de-facto, i thought he meant in this study on blood from lung screening patients | 04:10 |
| ryouma | we have /some/ primers now. didn't they have samples? | 04:11 |
| LjL | but also maybe PCR *was* done, i mean, i didn't read the full study text that de-facto linked (from a slightly pirate-y site? it looked funny O.o) because i got annoyed and got away from the computer, so | 04:11 |
| LjL | ryouma, sure they had samples, that's how they found antibodies. but again, if the antibodies had had time to be there and do there work, negative PCR wouldn't mean anything IMO | 04:12 |
| LjL | it would just mean that those people had fought off the virus | 04:12 |
| LjL | since those people weren't known to be *sick* | 04:12 |
| ryouma | ok | 04:12 |
| de-facto | yes no test prior to suspecting a new disease or pathogen | 04:13 |
| LjL | urgh i think we're talking past each other | 04:13 |
| LjL | we have tests now. this study is being done now. on blood from before. | 04:13 |
| LjL | but if you have blood from a patient who had an immune response *in the past*, and he's seropositive, a negative PCR would just tell you the virus is now gone, as it should | 04:14 |
| de-facto | yes exactly, what i meant is they did not had PCR tests back then hence could not test for a new pathogen with it | 04:14 |
| LjL | de-facto, they weren't even suspecting there could be a pathogen. they were just screening people for lung cancer! | 04:14 |
| de-facto | yeah | 04:15 |
| LjL | if i'm not too mistaken this is a trial that my dad took part in | 04:15 |
| LjL | though not during the months involved | 04:15 |
| de-facto | hmm but even if they would do PCR of those blood samples, what would be the chances to find viral RNA in there? id guess that only should be there for severe cases or is it also there for mild ones? | 04:21 |
| de-facto | like to find some blood samples for sequencing i mean | 04:21 |
| LjL | so i look at the backscroll since it seems i really should, and i find things like (from bolovanos, no idea their IRC nickname) "considering fact, that we play global game of who fault that is... so being sceptical is at place, I think" - and i'm like, WHAT? THIS is the oft-unspoken-but-implied background thing that gets on my nerves. what the hell, these studies are Italian, we have absolutely no interest in trying to make people think it came from Italy! | 04:23 |
| LjL | it's about the SCIENCE not the POLITICS, and if we based whether we are "skeptical or not" on the politics instead of the science, when what i'm showing is science and not politics, well that gets on my nerves. it just does. | 04:23 |
| LjL | also italians may well be inept on a lot of stuff, like for example upstream reporting of new medical issues (anything that involves bureaucracy, really), and i'll be the first to admit that (repeatedly), but that doesn't mean studies done here are crap, which is honestly the vibe i get from reddit and stuff. they may be underfunded, so that may sometimes be one explanation why they didn't do *everything* including the kitchen sink. the hope is that others | 04:25 |
| LjL | will notice and dig further, but if the automatic reaction is "naah, another italian sewage study, we don't believe that stuff" that'll never happen | 04:25 |
| LjL | i think the reactions i see here or on reddit are not necessarily reactions that AREN'T reflected by the international scientific community, and that annoys and/or concerns me | 04:26 |
| de-facto | wasnt there something like that in Barcelona too? | 04:30 |
| de-facto | i remember having read about quite something similar, but my memories are clouded | 04:30 |
| LjL | de-facto, yes, and in Brazil, but i haven't read the studies. and something in France but i'm not sure if that was just from an autopsy or also from sewage | 04:31 |
| de-facto | %title https://www.medrxiv.org/content/10.1101/2020.06.13.20129627v1 <-- was it this one? | 04:31 |
| Brainstorm | de-facto: From www.medrxiv.org: Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases | medRxiv | 04:31 |
| LjL | seems likely, but i don't know | 04:32 |
| LjL | anyway the word "sequence" never appears, so... | 04:32 |
| de-facto | %title https://www.medrxiv.org/content/10.1101/2020.06.26.20140731v1 <-- and this one? | 04:33 |
| Brainstorm | de-facto: From www.medrxiv.org: SARS-CoV-2 in human sewage in Santa Catalina, Brazil, November 2019 | medRxiv | 04:33 |
| LjL | i can see if those URL show up before in the channel, but since i didn't put those studies into the links list, that's all i can do | 04:34 |
| ryouma | the fact that the study was italian, in italy, about italy, or by italians never even occurred to me to be of any particular significance, nor to my other source that was commenting on why they didn't think the study mattered much. they think lots of studies don't matter much. | 04:35 |
| CoronaBot | 04/r/coronavirus: Doctors Are Calling It Quits Under Stress of the Pandemic (10261 votes) | https://www.nytimes.com/2020/11/15/health/Covid-doctors-nurses-quitting.html | https://redd.it/juumk2 | 04:36 |
| LjL | i linked to the latter here, and tinwhiskers linked to the former in ##coronavirus, between may and june | 04:36 |
| ryouma | politics is interesting i guess only inasmuch as it can corrupt science, including by what gets studied or not studied | 04:36 |
| LjL | if anything, since these two studies from spain and brazil don't appear to mention sequencing at all, italy went a step further by sequencing at least *part* of it | 04:37 |
| de-facto | yeah afaik they also were the first that sequenced the full D614G strain at least thats what they say in the cell paper | 04:38 |
| de-facto | which does not mean it originated there, only that they were the first that captured it | 04:38 |
| de-facto | basically it could have come from everywhere because of fast traveling via airplane | 04:39 |
| ryouma | i am concerned that the systems of society can break down in places like the us in the next couple of months, due to thanksgiving and fewew measures and overwhelmed hospitals and icus and everybody being childish | 04:39 |
| LjL | look at this. https://np.reddit.com/r/COVID19/comments/juabvy/unexpected_detection_of_sarscov2_antibodies_in/gcfo41w/?context=3 apparently, also based on backscroll, we accept China's results as more or less valid, even partly because we don't have access to their sample to replicate them. but here, we need "independent GROUPS of researchers" to confirm this as vaguely solid evidence? i think for some reason this stuff is just being held to a much higher | 04:40 |
| LjL | standard of evidence than most other stuff that floats around, and i don't get why | 04:40 |
| ryouma | because humans do that | 04:41 |
| LjL | well i am also humans and i get annoyed and sometimes upset, humans do that too | 04:41 |
| ryouma | i was not defending them. i was ssaying: humans are not as rational or scientific as they make themselves look like they are. they are geniuses at pretending to be what they are not. | 04:42 |
| LjL | agreed | 04:42 |
| ryouma | everybody is peter principle | 04:42 |
| ketas | pp is fun | 04:44 |
| jacklsw | what's pp? | 04:46 |
| jacklsw | oh peter principle? | 04:46 |
| ketas | jacklsw: yes | 04:55 |
| tinwhiskers | The thing is with China is that they did release a sequence very early on, and while there was a little doubt about that at first as soon as we sequenced the virus ourselves it showed that their sequence was genuine. | 05:35 |
| Brainstorm | New from r/WorldNews: worldnews: Coronavirus: South Australia goes on high alert after first outbreak in months → https://is.gd/rXMOGz | 05:41 |
| de-facto | %cases Germany | 05:47 |
| Brainstorm | Updates for US: +117822 cases (now 11.4 million), +506 deaths (now 251836) since 11 hours ago — Belgium: +4659 cases (now 535939), +118 deaths (now 14421) since 11 hours ago — Germany: +3211 cases (now 802944), +48 deaths (now 12692) since 11 hours ago — Netherlands: +1625 cases (now 450039), +16 deaths (now 8512) since 11 hours ago | 05:47 |
| Brainstorm | de-facto: In Germany, there have been 802944 confirmed cases (1.0% of the population) and 12692 deaths (1.6% of cases) as of 27 minutes ago. 25.0 million tests were performed (3.2% positive). Fatality can be broadly expected to lie between 0.5% (assuming prevalence as in tests) and less than 2.5% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Germany for time series data. | 05:47 |
| de-facto | RKI Germany: Infections +10 824 (801 327 total), Fatalities +62 (12 547 total) | 05:48 |
| Brainstorm | New from The Indian Express: World: N.Korea’s Kim orders tightening of anti-virus measures amid global pandemic → https://is.gd/8aBrBA | 05:59 |
| Brainstorm | New from The Indian Express: World: Doctors in US are calling it quits under stress of the pandemic → https://is.gd/YrGfi3 | 06:18 |
| Brainstorm | New from r/WorldNews: worldnews: Chilling Video Shows Texas Prisoners Removing Dead Bodies of Coronavirus Patients → https://is.gd/nNvNl3 | 07:14 |
| Brainstorm | New from r/WorldNews: worldnews: Covid 19: Boris Johnson self-isolating as week of policy announcements begins → https://is.gd/FXgTqe | 08:47 |
| Brainstorm | New from The Indian Express: World: UK to run final stage trials of Janssen Covid vaccine → https://is.gd/qZ9yjN | 09:06 |
| Brainstorm | New from Medical Xpress: Venezuela to buy 10 million doses of Russian COVID-19 vaccine: Venezuelan President Nicolas Maduro said Sunday that his government has agreed to buy 10 million doses of Russia's Sputnik V vaccine against COVID-19. → https://is.gd/SIAvdy | 09:27 |
| Brainstorm | New from Medical Xpress: Australia races to contain Adelaide virus outbreak: A sudden coronavirus cluster emerged in the Australian city of Adelaide on Monday after seven months without a significant outbreak there, with the virus again escaping from the country's hotel quarantine system. → https://is.gd/guRtai | 09:37 |
| CoronaBot | 04/r/covid19: A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2 (80 votes) | https://www.sciencedirect.com/science/article/pii/S004268222030204X | https://redd.it/julhn8 | 09:55 |
| Brainstorm | New from Medical Xpress: Merkel eyes schools, contacts in tougher virus curbs push: Chancellor Angela Merkel will on Monday push for tougher curbs including masks in all schools, smaller class sizes and drastic limits on contacts to bring down coronavirus infections in Germany. → https://is.gd/9YrCMk | 10:06 |
| Brainstorm | New from "Cluster 5" on Wikipedia: Biscuit-in-Chief: Biscuit-in-Chief: "cluster 5" is the name of the mutation (as far as I've understood, the name is only a popular name and not a scientific one; see Talk:Cluster 5#Is "cluster 5" a scientific name for the mutated variant or a popular name?) → https://is.gd/74bzDF | 10:37 |
| Brainstorm | New from StatNews: Watch: How did you get your start in science? And other questions with the STAT Wunderkinds: STAT asked this year's class of STAT Wunderkinds about how they got their start in science, how their work has changed during Covid-19, and more. → https://is.gd/zOVr9B | 10:49 |
| DocScrutinizer05 | FWIW D 10824 -20% weekly reference | 10:49 |
| DocScrutinizer05 | thi is hardly a saturation effect or changed test strategy, in my book | 10:52 |
| Brainstorm | New from CNBC Health: The creator of the Pfizer-BioNTech vaccine says life could return to normal by next winter: Professor Ugur Sahin, co-founder and chief executive of BioNTech, also suggested the coronavirus vaccine could halve transmission of the virus. → https://is.gd/qZi7Ai | 10:58 |
| Brainstorm | New from StatNews: STAT+: J&J supply chain exec: ‘I lose sleep’ over sending Covid-19 vaccine to lower-income countries: "What I lose sleep over at night is making sure we can send product to lesser-developed countries," says the executive overseeing the Covid-19 vaccine supply chain for the Janssen unit… → https://is.gd/Uxjn27 | 11:08 |
| Brainstorm | New from ProPublica: Rapid Testing Is Less Accurate Than the Government Wants to Admit: by Lisa Song ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. The promise of antigen tests emerged like a miracle this summer. With repeated use, the theory went, these rapid [... want %more?] → https://is.gd/LGaHAB | 11:29 |
| Brainstorm | New from Retraction Watch: Co-authors of paper on COVID-19 and jade amulets blame ‘the online press’ and social media for misinterpretation in retraction letter: The co-authors of a paper that claimed jade amulets might prevent COVID-19 have tried to distance themselves from the work, in a letter to the co-editor of the journal that published it. [... want %more?] → https://is.gd/tC4bQk | 12:10 |
| Brainstorm | New from BBC Health: Moderna: Covid vaccine shows nearly 95% protection: The results add to growing confidence that vaccination can end the pandemic. → https://is.gd/EKuWCw | 13:07 |
| Brainstorm | New from The Indian Express: World: Moderna says its Covid-19 vaccine appears to be 94.5% effective → https://is.gd/PVIXAP | 13:16 |
| CoronaBot | 04/r/covid19: Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study (93 votes) | https://investors.modernatx.com/news-releases/news-release-details/modernas-covid-19-vaccine-candidate-meets-its-primary-efficacy | https://redd.it/jv5mnc | 13:20 |
| Brainstorm | New from StatNews: Moderna’s Covid-19 vaccine is strongly effective, early look at data show: Moderna’s vaccine against Covid-19 delivered strong efficacy, building excitement about the potential of controlling the global pandemic, the company said Monday. → https://is.gd/qLg7GQ | 13:26 |
| Brainstorm | New from CNBC Health: (news): Moderna says preliminary trial data shows its coronavirus vaccine is more than 94% effective, shares soar → https://is.gd/pyZZCx | 13:45 |
| Brainstorm | New from Medical Xpress: Second coronavirus vaccine shows early success in U.S. tests: For the second time this month, there's promising news from a COVID-19 vaccine candidate: Moderna said Monday its shots provide strong protection, a dash of hope against the grim backdrop of coronavirus surges in the U.S. and around the world. → https://is.gd/3Ud9Hl | 13:54 |
| Brainstorm | New from Medical Xpress: Identification of the SARS-CoV-2 virus features that cause COVID-19: Features of the SARS-CoV-2 virus causing COVID-19, which could be useful for developing vaccines and treatment strategies, were identified using a nonhuman primate model developed at the Korea Research Institute of Bioscience and Biotechnology (KRIBB). → https://is.gd/zwyQ7I | 14:04 |
| Brainstorm | New from Medical Xpress: Excess death toll in care homes from COVID-19 'hugely underestimated': An early draft of a study by University of Manchester health economists and data scientists calculates that up to 10,000 more people may have died in care homes from COVID-19 than previously realized. → https://is.gd/XBAXBg | 14:13 |
| cloud69 | LjL: howdy! you around? | 14:16 |
| Brainstorm | cloud69: At 2020-11-15 17:01:57 UTC, LjL told you: Brainstorm has no special knowledge of Reddit, it just uses its RSS feeds (just add .rss to a subreddit URL for the simple version, but it can also RSS-ize searches and stuff) | 14:16 |
| cloud69 | oh cool | 14:16 |
| cloud69 | man this bot is so cool | 14:16 |
| Brainstorm | New from CNBC Health: 5 things to know before the stock market opens Monday: Dow futures soared Monday after Moderna said its preliminary trial data showed its coronavirus vaccine was more than 94% effective. → https://is.gd/Gf75j7 | 14:23 |
| Brainstorm | New from CNBC Health: ‘We could effectively end this pandemic in 2021' with Pfizer and Moderna Covid vaccines: "If these full data sets hold, when the full data comes out, we may have two highly effective vaccines against Covid," Dr. Scott Gottlieb told CNBC on Monday. → https://is.gd/kVGmDl | 14:42 |
| Brainstorm | New from Medical Xpress: Strict COVID-19 measures in the Northern Territory have smashed the curve: The Northern Territory's strict public health measures in response to COVID-19 have so far proved successful in containing community transmission and preventing any deaths, despite the NT hospital system often operating "beyond capacity," according to [... want %more?] → https://is.gd/i3MhmA | 14:52 |
| Brainstorm | New from Medical Xpress: Researchers help world to breathe free amid COVID-19 resurgence: Simple, low-cost technology developed by University of Canterbury (UC) engineers could save thousands of lives by doubling the capacity of ventilators in hospital intensive care units, boosting the capacity to treat overwhelming patient surges during COVID-19 outbreaks. → https://is.gd/Nzzh4O | 15:01 |
| Brainstorm | New from Medical Xpress: Multiple simulations best for COVID-19 predictions: Computer modelling used to forecast COVID-19 mortality contains significant uncertainty in its predictions, according to a new study led by researchers at UCL and the CWI institute in the Netherlands. → https://is.gd/exJ1YL | 15:20 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Moderna says its Covid-19 vaccine is strongly effective; cyberattacks targeted seven firms working on the coronavirus → https://is.gd/umZCDY | 15:30 |
| de-facto | the Twitter accounts from BioNtech founders Ugur Sahin and Özlem Türeci are faked, dont fall for it | 15:32 |
| CoronaBot | 04/r/coronavirus: Moderna’s coronavirus vaccine found to be nearly 95 percent effective in a preliminary analysis (10839 votes) | https://www.washingtonpost.com/health/2020/11/16/covid-moderna-vaccine/ | https://redd.it/jv5mem | 15:32 |
| Brainstorm | New from Medical Xpress: Why we should prioritise older people when we get a COVID vaccine: While we wait for further results from phase 3 trials, it's clear that supply of any potential COVID vaccine would initially be limited. → https://is.gd/tJ8Zv3 | 15:40 |
| de-facto | Hard fighting of the ministers with Merkel about further containment measures | 15:41 |
| de-facto | not a good sign :( | 15:42 |
| rpifan | so whats the prognonsis yall | 15:42 |
| rpifan | for germany | 15:43 |
| de-facto | i think its not good, the ministers dont want to cooperate | 15:46 |
| de-facto | schools probably will stay open | 15:46 |
| de-facto | probably there only will be like new recommendations or such | 15:47 |
| de-facto | this is going to be a mistake, we need MUCH harder containment | 15:47 |
| de-facto | meanwhile Ungarn and Poland block the Corona financial help because they fear their governments will be judged not democratic enough | 15:49 |
| de-facto | %title https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-longer-shelf-life-its-covid-19-vaccine | 15:54 |
| Brainstorm | de-facto: From investors.modernatx.com: Moderna Announces Longer Shelf Life for its COVID-19 Vaccine Candidate at Refrigerated Temperatures | Moderna, Inc. | 15:54 |
| de-facto | %title https://investors.modernatx.com/news-releases/news-release-details/modernas-covid-19-vaccine-candidate-meets-its-primary-efficacy | 15:54 |
| Brainstorm | de-facto: From investors.modernatx.com: Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study | Moderna, Inc. | 15:54 |
| cloud69 | LjL: kinda wish it wasn't confined to irc :) | 15:54 |
| cloud69 | LjL: im working on porting brainstorm to ruby on rails for this local corona app. any chance you could give some feedback once it's done? | 15:55 |
| de-facto | %title https://www.modernatx.com/cove-study | 15:55 |
| Brainstorm | de-facto: From www.modernatx.com: Moderna’s Fully Enrolled Phase 3 COVE Study of mRNA-1273 | Moderna, Inc. | 15:55 |
| cloud69 | LjL: and youll get the source code ofcourse :D | 15:56 |
| de-facto | %title https://www.modernatx.com/sites/default/files/content_documents/2020-COVE-Study-Enrollment-Completion-10.22.20.pdf | 15:57 |
| de-facto | %title https://www.modernatx.com/sites/default/files/mRNA-1273-P301-Protocol.pdf | 15:57 |
| Brainstorm | de-facto, the URL could not be loaded | 15:57 |
| de-facto | well yeah its a pdf, alright it just fine though | 15:58 |
| Brainstorm | de-facto, the URL could not be loaded | 15:58 |
| de-facto | ..."the trial has met the statistical criteria pre-specified in the study protocol for efficacy, with a vaccine efficacy of 94.5%. This study, known as the COVE study, enrolled more than 30,000 participants in the U.S"... | 16:00 |
| de-facto | ..."The primary endpoint of the Phase 3 COVE study is based on the analysis of COVID-19 cases confirmed and adjudicated starting two weeks following the second dose of vaccine. This first interim analysis was based on 95 cases, of which 90 cases of COVID-19 were observed in the placebo group versus 5 cases observed in the mRNA-1273 group, resulting in a point estimate of vaccine efficacy of 94.5% (p <0.0001)"... | 16:00 |
| de-facto | ..."A secondary endpoint analyzed severe cases of COVID-19 and included 11 severe cases (as defined in the study protocol) in this first interim analysis. All 11 cases occurred in the placebo group and none in the mRNA-1273 vaccinated group."... | 16:01 |
| de-facto | ..."The 95 COVID-19 cases included 15 older adults (ages 65+) and 20 participants identifying as being from diverse communities (including 12 Hispanic or LatinX, 4 Black or African Americans, 3 Asian Americans and 1 multiracial)."... | 16:01 |
| de-facto | ..."The majority of adverse events were mild or moderate in severity. Grade 3 (severe) events greater than or equal to 2% in frequency after the first dose included injection site pain (2.7%), and after the second dose included fatigue (9.7%), myalgia (8.9%), arthralgia (5.2%), headache (4.5%), pain (4.1%) and erythema/redness at the injection site (2.0%)."... | 16:02 |
| Brainstorm | New from Medical Xpress: Key patient insights the missing link in understanding COVID-19 and its mutations: A new study led by Australia's national science agency CSIRO, has found 95.5 percent of current entries in GISAID, the world's largest novel coronavirus genome database, do not contain relevant patient information—a critical piece of the puzzle [... want %more?] → https://is.gd/YGK2aH | 16:08 |
| Brainstorm | New from Medical Xpress: In second breakthrough, Moderna's Covid vaccine 'highly effective': US biotech firm Moderna on Monday announced its experimental vaccine against COVID-19 was almost 95 percent effective, marking a second major breakthrough in the quest to end the pandemic. → https://is.gd/M7Ckn8 | 16:27 |
| de-facto | %title https://www.curevac.com/en/2020/11/10/curevac-publishes-detailed-interim-phase-1-data-of-its-covid-19-vaccine-candidate-cvncov/ | 16:28 |
| Brainstorm | de-facto: From www.curevac.com: CureVac Publishes Detailed Interim Phase 1 Data of its COVID-19 Vaccine Candidate, CVnCoV – CureVac | 16:28 |
| de-facto | %title https://www.medrxiv.org/content/10.1101/2020.11.09.20228551v1 | 16:28 |
| Brainstorm | de-facto: From www.medrxiv.org: Phase 1 Assessment of the Safety and Immunogenicity of an mRNA- Lipid Nanoparticle Vaccine Candidate Against SARS-CoV-2 in Human Volunteers | medRxiv | 16:28 |
| de-facto | %tr <de Die EU-Kommission hat mit der Tübinger Firma Curevac einen Vertrag über den Kauf von bis zu 405 Mio. Dosen Corona-Impfstoff vereinbart. Dies teilte Kommissionspräsidentin Ursula von der Leyen am Montagnachmittag in Brüssel mit. | 16:30 |
| Brainstorm | de-facto, German to English: The EU Commission has agreed a contract with the Tübingen-based company Curevac for the purchase of up to 405 million doses of corona vaccine. This was announced by Commission President Ursula von der Leyen on Monday afternoon in Brussels. (MyMemory) [... want %more?] | 16:30 |
| de-facto | https://www.n-tv.de/ticker/Von-der-Leyen-Impfstoff-Vertrag-mit-Curevac-abgeschlossen-article22172603.html | 16:30 |
| Brainstorm | New from Medical Xpress: Obese people found to be at increased risk of COVID-19: A new study led by researchers at Queen Mary University of London uses a novel approach to investigate the effects of cardiovascular risk factors on the risk of COVID-19 infection. → https://is.gd/ZyRlWv | 16:37 |
| Brainstorm | New from StatNews: Health: With strong data on two Covid-19 vaccines, we have more answers about the road ahead — and questions too → https://is.gd/6e7ciK | 16:47 |
| Brainstorm | New from ClinicalTrials.gov: (news): A Smartphone Intervention for Relational and Mental Well Being → https://is.gd/zXBdar | 17:06 |
| Brainstorm | New from CNBC Health: (news): HHS Secretary Azar says the FDA will move 'as quickly as possible' to clear Moderna and Pfizer's Covid vaccines → https://is.gd/HWeAaf | 18:14 |
| Brainstorm | New from The Indian Express: World: Travel restrictions challenge vaccine rollout, airlines warn → https://is.gd/GIDbFJ | 18:24 |
| LjL | cloud69, Brainstorm isn't technically confined to IRC, in fact the earthquakes stuff it does is also on Twitter, Reddit and Matrix... but it did start out as an IRC bot so the interactive stuff (command-response) is only available on IRC. i also need to hurry up and port it all to Python 3 as it's still running on Python 2 which both makes it very slow and quirky, and after the end of 2020 Python 2 won't even be supported anymore | 18:31 |
| LjL | some unsettling (anecdotal but unsettling) news courtesy of IndoAnon: https://nitter.net/itosettiMD_MBA/status/1328099338149564416 :\ | 18:32 |
| cloud69 | nice! | 18:37 |
| cloud69 | ouch @ indoanon, yeah thats pretty messed up | 18:38 |
| cloud69 | LjL: dont you think your bot could be some sorta newssite/forum too? | 18:42 |
| cloud69 | i see potential lol | 18:42 |
| LjL | not particularly :P | 18:42 |
| LjL | i mean, it mostly just posts stuff from RSS feeds here | 18:43 |
| LjL | that's what an RSS aggregator does, and those already exist on the web | 18:43 |
| LjL | (although RSS is not very popular anymore) | 18:43 |
| cloud69 | hmmm | 18:43 |
| LjL | it does a lot of other stuff too and originally at least, the RSS stuff was just an afterthought. it was originally a linguistics bot | 18:44 |
| LjL | %pr linguistics | 18:44 |
| cloud69 | those rss feeds basically gives the same news as the media right? whereas twitter is more like, from the people? | 18:44 |
| Brainstorm | LjL, English pronunciation: /lɪŋgwˈɪstɪks/ (CMU, American) — /lɪŋˈɡwɪstɪks/ (Moby, American) — [lɪŋɡwˈɪstɪks] (eSpeak, British) — [lɪŋɡwˈɪstɪks] (eSpeak, American) → Audio unavailable. | 18:44 |
| cloud69 | hehe wow | 18:44 |
| LjL | cloud69, RSS feeds *are* literally news media sites providing (some of) their content as a machine-parsable feed so that people can sift through news without explicitly opening every news site they are interested in | 18:45 |
| LjL | even the stuff it posts from Reddit it just posts because Reddit provides an RSS feed of every subreddit (just add .rss at the end of the URL) | 18:45 |
| cloud69 | ah ok | 18:45 |
| cloud69 | i gotta look that up, i was planning to scrape reddit actually for this online forum im setting up. ive been advised against using their api | 18:48 |
| LjL | i use their API for *posting* on reddit (the earthquake stuff) | 18:48 |
| LjL | i don't know if it's any good for *getting* posts | 18:48 |
| cloud69 | ooh, yeah makes sense then | 18:48 |
| cloud69 | i dont think its good. according to this guy, i forgot the channel, they like to mess with you | 18:49 |
| LjL | but keep in mind that it's likely their ToS forbid scraping (i'm just guessing, usually they do) so be careful what you do | 18:49 |
| cloud69 | put out fake content, buncha redirects and stuff | 18:49 |
| cloud69 | indeed thanks for the concern | 18:49 |
| cloud69 | hehe i was thinking | 18:49 |
| cloud69 | came across https://quillbot.com/ today and am considering feeding reddit posts and comments into this thing | 18:50 |
| cloud69 | unique content for ya! :D | 18:50 |
| cloud69 | can you make Brainstorm do something similar? i think quillbot is python | 18:51 |
| cloud69 | you python dudes always have the best projects. nobody's even heard of ruby | 18:51 |
| Brainstorm | New from Medical Xpress: Single institution study finds high rates of cardiac complications in MIS-C: During the height of the pandemic, researchers at Children's National Hospital discovered that as many as one half of children diagnosed with multisystem inflammatory disease in children (MIS-C) at the hospital developed cardiac complications including [... want %more?] → https://is.gd/1WY4Nl | 18:53 |
| LjL | cloud69, hmm that's interesting from a NLP perspective but not really something Brainstorm would benefit from... and it's not an open source project as far as i can see. you have to pay for their API, i don't know if it's ultimately Python but you certainly can't just go and read their Python | 18:59 |
| CoronaBot | 04/r/covid19: Moderna’s Vaccine Efficacy Readout (84 votes) | https://blogs.sciencemag.org/pipeline/archives/2020/11/16/modernas-vaccine-efficacy-readout | https://redd.it/jv8759 | 19:03 |
| Brainstorm | New from Medical Xpress: How personality affects who follows COVID-19 rules: Individual personality traits make people up to a third more likely to adopt guidelines aimed at preventing the spread of COVID-19, a new study has found. → https://is.gd/c1ELk1 | 19:03 |
| Brainstorm | New from Medical Xpress: WHO hails 'encouraging' COVID vaccine news: The World Health Organization chief hailed Monday "encouraging" news about COVID-19 vaccines but expressed concern about surging cases in many countries and insisted that complacency was not an option. → https://is.gd/vtdfQK | 19:13 |
| cloud69 | LjL: true that! | 19:19 |
| cloud69 | LjL: anyway ill be back with brainstorm-rails in a bit :D | 19:20 |
| cloud69 | im making this corona site where brainstorm is the missing piece. the other parts are a mapbox map of the latest incidents (https://github.com/rodloboz/mapbox-clusters) and live chat | 19:21 |
| cloud69 | then im gonna put up stickers of the url everywhere. even the hospitals | 19:22 |
| Brainstorm | New from Medical Xpress: Experimental mRNA vaccines come to fore as pandemic rages: The "messenger RNA" technology used by the Pfizer and Moderna COVID-19 jabs works by hacking into the machinery of human cells and turning them into vaccine factories. → https://is.gd/6tUztz | 19:23 |
| cloud69 | err this is the right link to the map thingie: https://medium.com/lightthefuse/mapbox-clusters-with-ruby-on-rails-77a760432ddc | 19:23 |
| cloud69 | anywho cya in a bit! thanks for the chat! | 19:24 |
| LjL | cloud69, one thing we've really missed for a long time is a map/timeline of the various lockdown-type measures taken in all the various countries. like, are schools open, is non-essential work allowed, are shops open, etc | 19:26 |
| LjL | and, when did these restrictions start or stop | 19:26 |
| cloud69 | hmmm | 19:29 |
| cloud69 | now THAT'S a BRILLIANT idea man! | 19:29 |
| cloud69 | wonder how we'd visualize it though. hey speaking about visualizing check this out :) | 19:30 |
| cloud69 | gonna take a while my comp is super slow its like from the 90s | 19:31 |
| Brainstorm | New from Medical Xpress: Frontrunners emerge in race for Covid-19 vaccine: Dozens of companies, from biotech start-ups to Big Pharma, are racing to develop a safe and effective COVID-19 vaccine, both to meet urgent medical need and for the potential payday. → https://is.gd/MLEWMZ | 19:32 |
| cloud69 | as for your idea, assuming we have the data, we could use mapbox gl js to display a world map. with lockdown measures represented as icons above, then when user hovers the icons, parts of the map will extrude? | 19:32 |
| cloud69 | LjL: could also track mutations i guess. i went looking the other day and found https://nextstrain.org/ncov/europe | 20:05 |
| cloud69 | LjL: https://imgur.com/a/vdbKUak lol | 20:05 |
| cloud69 | brb | 20:06 |
| LjL | cloud69, yeah but you'd have to scrape it as nextstrain has no API that i could find | 20:07 |
| LjL | not sure it's easy to scrape | 20:07 |
| LjL | also i hope nobody sues me about Brainstorm, he's had this name for several years ;( | 20:07 |
| LjL | de-facto, i missed the whole Moderna news except for TV, i opened your links to the study and... some graphics slides, apparently? but have you seen something like a statement or a press release that i could put into the "News" section, or a good article from a reputable paper? | 20:16 |
| Brainstorm | New from Medical Xpress: Texas surpasses 20,000 virus deaths, second highest in US: Texas surpassed 20,000 confirmed coronavirus deaths Monday, as COVID-19 continues to surge in the United States. → https://is.gd/tymLTh | 20:20 |
| LjL | weeeee i'm opening a lot of links | 20:24 |
| LjL | can't take half a day away from the coronavirus stuff without lagging behind a lot | 20:24 |
| LjL | but at least it's good news | 20:24 |
| tinwhiskers | hey, Texan's aren't all that bad! | 20:32 |
| tinwhiskers | erm. Why did I use an apostrophe for a plural? | 20:33 |
| tinwhiskers | shameful behaviour | 20:33 |
| LjL | it's okay, tinwhisker's, don't be hard on yourself | 20:37 |
| tinwhiskers | lol | 20:37 |
| LjL | is my understanding correct that there is no study paper from Moderna out yet? we have the press release, and the long study *protocol* but not the study results? | 20:45 |
| Brainstorm | New from https://covid19.specops.network : Add news about Moderna vaccine interim trial showing 94% efficacy: Adding in both News and Vaccines section, bit haphazardly since in News I put a press release, and in Vaccines I put a news piece anyway... not sure how to organize this better, I should have the fully study paper (not out yet? only the [... want %more?] → https://is.gd/JIE5qA | 20:49 |
| tinwhiskers | LjL: does your bot actually follow the conversation and post relevant links or is it just a huge coincidence it keeps doing this? | 20:50 |
| tinwhiskers | oh. You just added that one. d'oh. | 20:51 |
| LjL | tinwhiskers, eh, the other times it was coincidence, but this time this is *me* adding information to the covid19.specops.network :P | 20:51 |
| LjL | it's the reason i asked those questions basically | 20:51 |
| tinwhiskers | aha :-) | 20:51 |
| LjL | it's not very fair though, i added nothing about the Pfizer news | 20:52 |
| Jigsy | I see the UK are getting excited over this American vaccine as well. | 20:53 |
| Jigsy | Even though America's priority right now is America. | 20:53 |
| Jigsy | Not other countries. | 20:53 |
| LjL | Jigsy, i don't know about the UK, but the EU appears to have a contract with Pfizer and i think also Moderna | 21:03 |
| Jigsy | It's not really the contractual obligation. | 21:27 |
| Jigsy | It's more the "limited numbers of vaccine" angle. | 21:27 |
| Jigsy | America will prioritize treating it's own countrymen first. | 21:27 |
| LjL | Jigsy, well that also depends on what the contractual obligation is though. i guess there's always the possibility that the US requisitions them in the name of national interest, which i've always been a bit worried about, but doing that would be a pretty big deal | 21:30 |
| de-facto | LjL https://blogs.sciencemag.org/pipeline/archives/2020/11/16/modernas-vaccine-efficacy-readout | 21:34 |
| genera | i think i read somewhere that modeRNAs ceo opposes such requisition | 21:35 |
| tinwhiskers | it would be a big deal but they've done it before with masks so it's not impossible | 21:37 |
| Brainstorm | New from NPR: NCAA Takes A Shot At Hosting 2021 Men's March Madness Tournament In One Area: The NCAA said hosting a tournament across 13 U.S. cities "would be very difficult to execute." Talks are underway to try to hold all 67 games of the tournament in Indianapolis in March and April. → https://is.gd/wMDVQY | 21:39 |
| de-facto | LjL, https://blogs.sciencemag.org/pipeline/archives/2020/11/09/vaccine-efficacy-data | 21:48 |
| Brainstorm | New from Medical Xpress: Should you travel for the holidays?: Want to head home for the holidays? You may need to reconsider your travel plans because of the COVID-19 pandemic. → https://is.gd/smYxIM | 21:50 |
| tinwhiskers | Pfizer said they would un-blind and give the placebo arm the vaccine if it was approved. | 21:56 |
| tinwhiskers | Wow. I wish I could have participated in the trial. | 21:57 |
| tinwhiskers | I really hope there is some way to wangle getting into a priority group. Maybe I need to volunteer on the front line when I get home. | 21:58 |
| tinwhiskers | Still it's going to take a while for border control regulations around the world to make accommodations for people who have been vaccinated. | 21:59 |
| Brainstorm | New from CNBC Health: (news): President-elect Biden says he wouldn't hesitate to get the coronavirus vaccine → https://is.gd/8lGKzW | 21:59 |
| tinwhiskers | stop it Brainstorm! Get out of my head. | 21:59 |
| tinwhiskers | iirc one third of the Pfizer participants got the placebo. | 22:01 |
| Brainstorm | New from PLOS ONE: Point-of-care diagnostic tests for influenza in the emergency department: A cost-effectiveness analysis in a high-risk population from a Canadian perspective: by Stephen Mac, Ryan O’Reilly, Neill K. J. Adhikari, Robert Fowler, Beate Sander Background Our objective was to assess the cost-effectiveness of novel rapid diagnostic [... want %more?] → https://is.gd/pTwEKk | 22:09 |
| Brainstorm | New from PLOS ONE: Molecular screening for the mutation associated with canine degenerative myelopathy ( SOD1 : c . 118G > A ) in German Shepherd dogs in Brazil: by Cássia Regina Oliveira Santos, João José de Simoni Gouveia, Gisele Veneroni Gouveia, Flávia Caroline Moreira Bezerra, Joel Fonseca Nogueira, Durval Baraúna Júnior Canine Degenerative [... want %more?] → https://is.gd/jxQN7z | 22:19 |
| LjL | tinwhiskers, it's easy to wish you'd been in the trial after the trial has shown efficacy and lack of serious adverse reactions :P | 22:50 |
| LjL | imagine if they all dropped dead like flies! | 22:51 |
| blkshp | Oh no, the flies... the fliiiiies | 22:53 |
| tinwhiskers | heh. yeah, hindsight is wonderful | 22:58 |
| tinwhiskers | Phase 3 trials should be fairly safe though and you'd get the best care to ensure the vaccine news is not too negative. | 22:59 |
| tinwhiskers | of course there is a chance you'd be in a trial that never gets approval in the end and it could be much worse too if the vaccine you get ends up causing ADE or suchlike. | 23:00 |
| tinwhiskers | But on balance, if I was back home (obviously you'd be mad to do anything that might require medical care here) I'd participate in a phase 3 trial. | 23:01 |
| Brainstorm | New from Medical Xpress: Researchers examine COVID-19-associated kidney injury in US veterans: An analysis of data from across the U.S. indicates that acute kidney injury (AKI) is common among hospitalized veterans with COVID-19, and it's associated with a higher risk of death. The analysis, which appears in an upcoming issue of CJASN, also found that [... want %more?] → https://is.gd/4BdfCq | 23:08 |
| Brainstorm | New from NPR: Iowa Doctor Says Money And Staffing Needed To Handle Coronavirus In Nursing Homes: Dr. Glenn Hurst says hospitalizations are growing in part because of a nursing home "bottleneck." Many people rehabilitate at nursing homes after leaving the hospital. → https://is.gd/mABXp1 | 23:55 |
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