| DocScrutinizer05 | get well soon! | 00:02 |
|---|---|---|
| DocScrutinizer05 | good luck | 00:02 |
| Brainstorm | Updates for New Hampshire, US: +1187 cases (now 29460), +6 deaths (now 590) since a day ago | 00:05 |
| CoronaBot | 04/r/covid19: Suggested role of Vitamin D supplementation in COVID-19 severity (80 votes) | http://www.jocms.org/index.php/jcms/article/view/822/424 | https://redd.it/kb9bnj | 00:07 |
| DocScrutinizer05 | LjL: sorry, I was trapped in regex maze. -->>> <mo2000> (.*foo.*bar){0,1}.*bla.* ;; or (.*PLOS ONE.*(corona|covid|cov2|SARS))?(coronavirus|COVID|outbreak|pa.... | 00:20 |
| LjL | DocScrutinizer05, PLOS ONE isn't part of the text being parsed though. but i guess that'd be easy-ish to hack in | 00:20 |
| DocScrutinizer05 | sorry, (.*PLOS ONE.*(corona|covid|cov2|SARS))?.*(coronavirus|COVID|outbreak|pa.... | 00:21 |
| CoronaBot | 04/r/covid19: Short of Breath for the Long Haul: Diaphragm Muscle Dysfunction in Survivors of Severe COVID-19 as Determined by Neuromuscular Ultrasound (81 votes) | https://www.medrxiv.org/content/10.1101/2020.12.10.20244509v1 | https://redd.it/kb5h4k | 00:37 |
| Brainstorm | New from CNBC Health: CDC will monitor for Bell’s palsy among Pfizer vaccine recipients, but sees no causal relationship: There is "no known or expected causal relationship between the vaccine and Bell's palsy," the Centers for Disease Control and Prevention said Friday. → https://is.gd/Hfw2IR | 00:40 |
| de-facto | %title https://sputnikvaccine.com/newsroom/pressreleases/astrazeneca-will-test-using-component-of-russia-s-sputnik-v-in-clinical-trials-of-its-own-vaccine-ag/ | 00:40 |
| Brainstorm | de-facto: From sputnikvaccine.com: AstraZeneca will test using component of Russia’s Sputnik V in clinical trials of its own vaccine against coronavirus | Official website vaccine against COVID-19 Sputnik V. | 00:40 |
| de-facto | yet nothing on press releases from | 00:40 |
| de-facto | %title https://www.astrazeneca.com/media-centre/press-releases.html | 00:40 |
| Brainstorm | de-facto: From www.astrazeneca.com: Press Releases - AstraZeneca | 00:40 |
| LjL | are they sure they want to be associated with AZ :P | 00:48 |
| de-facto | im not quite sure what to think about this, a statement from AZ would help | 00:52 |
| CoronaBot | 04/r/covid19: Update on The University of Queensland COVID-19 vaccine (80 votes) | https://www.csl.com/news/2020/20201211-update-on-the-university-of-queensland-covid-19-vaccine | https://redd.it/kaptcu | 01:13 |
| Skunny | https://allevents.in/sacramento/11th-annual-bad-santa-costume-party-sat-dec-19/200020380832051 | 01:14 |
| Skunny | \m/ | 01:14 |
| de-facto | Corona Party? | 01:22 |
| Brainstorm | Updates for France: +13613 cases (now 2.4 million) since 23 hours ago — Netherlands: +8835 cases (now 595003), +63 deaths (now 9976) since 23 hours ago | 01:22 |
| de-facto | Perfect timing Bad Santa Costume Party on 2020-12-20 exactly 4 days before Christmas on 2020-12-24 | 01:23 |
| de-facto | If median incubation time is 5.2 days and viral load at maximum one day before onset of symptoms its scheduled for maximum efficiency to multiply available pathogen on a superspread event on such a party and bring it home to the elderly in the family as Christmas present | 01:25 |
| de-facto | (sorry for being sarcastic about it) | 01:25 |
| de-facto | hard to think of any idea that may be worse than this one of Bad Santa Costume Party | 01:26 |
| de-facto | lol well at least the naming seems appropriate | 01:27 |
| Riddick | Ha! What vaccine trials? | 01:46 |
| ryouma | to what degree was thanksgiving superspreader | 01:47 |
| LjL | %links covidvax | 01:49 |
| Brainstorm | LjL, https://covidvax.org/ (CovidVax), an updated list of COVID-19 vaccines — https://covidvax.news/ (COVID-19 Vaccine News) has a map of expected deployment times, as well as a timeline of news and a table with progress of each vaccine, for a smaller amount of vaccine than CovidVax (which it shouldn't be confused with, as they are separate sites) | 01:49 |
| LjL | Riddick, ↑ | 01:49 |
| Brainstorm | New from r/WorldNews: worldnews: Germany ICU capacity at 'critical' level: An intensive care doctor has warned that rising infections have left only five to 10% of intensive care beds available in parts of Germany → https://is.gd/RuvJFj | 01:53 |
| Brainstorm | Updates for Curacao: +97 cases (now 3501), +2 deaths (now 10) since 21 hours ago | 02:08 |
| Brainstorm | New from CNBC Health: CDC will monitor for Bell’s palsy among Pfizer vaccine recipients, but sees no causal relationship: There is "no known or expected causal relationship between the vaccine and Bell's palsy," the Centers for Disease Control and Prevention said Friday. → https://is.gd/Hfw2IR | 02:17 |
| ryouma | there is no known or causal relationship for many things | 02:19 |
| ryouma | doesn't mean they don't have one | 02:19 |
| LjL | ryouma, what i think is it's *not* been as frequent as you'd expect in the general population | 02:29 |
| LjL | (i.e. it's been more, obviously) | 02:29 |
| LjL | ryouma, also i'll have a tooth extracted in a few days, join me | 02:30 |
| ryouma | i ahve to find out the precations at the oral surgen. still not done. | 02:31 |
| ryouma | why extracted | 02:31 |
| LjL | at this pace your mouth will have rotten before you're done. i know it's difficult but i'm not the impatient one, your mouth is | 02:31 |
| LjL | because it broke. it basically split longitudinally into two parts *cringe* | 02:31 |
| LjL | it had had a root canal years ago so it was weaker | 02:31 |
| LjL | and presumably i clench | 02:31 |
| LjL | it's one of my main molars so that's great | 02:32 |
| LjL | main as in the ones that get the bulk of the chewing | 02:32 |
| LjL | i was hoping i'd "just" get a crown but i didn't know it had literally split, although i kind of suspected it. | 02:34 |
| LjL | i may get an implant for it later, he said it'll depends on how the bone heals, and i suspect it costs an arm and a leg (and a tooth) | 02:35 |
| LjL | his agenda was pretty busy, and there were a few people in the waiting room | 02:36 |
| LjL | which didn't feel great | 02:36 |
| ryouma | they should get you from the car | 02:36 |
| LjL | get me from the car? | 02:37 |
| ryouma | from car to chair | 02:37 |
| LjL | that sounds unlikely to happen anywhere | 02:37 |
| ryouma | they go out and signal you or call ou | 02:37 |
| ryouma | it is probaboly standard in usa i think | 02:37 |
| LjL | they have an IR thermometer at the entrance and you have to disinfect your hands, that's standard procedure in most places here, but that's it | 02:38 |
| ryouma | or common | 02:38 |
| LjL | also Lombardy is going to be downgraded to a "yellow" region (i.e. least restrictions) in the next few days | 02:39 |
| LjL | so three two one thirdwave | 02:39 |
| LjL | oh and of course you have to wear a mask except when you're in the actual chair | 02:41 |
| LjL | didn't mention that because you have to wear a mask everywhere outside your home in italy so i forget | 02:41 |
| DocScrutinizer05 | LjL: sorry, I give up. You say you're using python? if re.search("PLOS ONE.*(corona|covid|SARS|cov2)", txt) or not re.search("PLOS ONE", txt): | 03:05 |
| Brainstorm | New from CNBC Health: (news): FDA advisor who voted against recommending Pfizer’s Covid vaccine explains why she would ‘be first in line’ to get it → https://is.gd/GejOUP | 03:05 |
| DocScrutinizer05 | should be just a matter of inserting this one line and identing below accordingly | 03:06 |
| DocScrutinizer05 | indenting even | 03:06 |
| LjL | You said even the COVID content was tangential at best, let's just leave it out | 03:11 |
| DocScrutinizer05 | :-) | 03:11 |
| Brainstorm | Updates for France: +13527 cases (now 2.4 million) since 23 hours ago — Netherlands: +8865 cases (now 597213), +64 deaths (now 9992) since 23 hours ago | 03:22 |
| Brainstorm | New from The Indian Express: World: Mexico approves emergency use of Pfizer’s COVID-19 vaccine → https://is.gd/xsDuDg | 03:29 |
| Brainstorm | Updates for South Korea: +950 cases (now 41736), +6 deaths (now 578) since 23 hours ago | 03:36 |
| KREYREEN | what's going to happen if people administrating the pfizer vaccine keep it in a temperature lower then the -80C? for X amount of time? | 03:37 |
| Brainstorm | New from CNBC Health: (news): FDA approves Pfizer's Covid vaccine for emergency use as U.S. reaches pivotal moment in the pandemic → https://is.gd/aO2oCA | 03:41 |
| DocScrutinizer05 | not much? I wonder why it's called Pfizer vaccine by particularly anglophone press ;-D Is it a tad embarrassing that BioNTech developed BNT162b2 and that's a german company that outsourced production to Pfizer? | 03:43 |
| KREYREEN | DocScrutinizer05, Why do you think that not much would happen? I would think that due to it being mRNA vaccine that there would be some unwanted sideeffects ? | 03:45 |
| de-facto | Assuming a specific energy threshold for a chemical bond in the mRNA molecule to break the decay rate of intact mRNA in such a vaccine in storage would depend exponentially on the temperature | 03:45 |
| KREYREEN | so if it was kept at room temperature it would probably became useless right | 03:46 |
| DocScrutinizer05 | I didn't hear of side effects from reducing storage temperature from < freezing to << freezing | 03:46 |
| DocScrutinizer05 | for anything really | 03:46 |
| DocScrutinizer05 | yes, at room temperature it doesn't last a two days iirc | 03:47 |
| KREYREEN | i see O.o so probably just efficiency loss? | 03:47 |
| DocScrutinizer05 | efficiency of storage, yes | 03:47 |
| KREYREEN | of storage? | 03:47 |
| KREYREEN | i though efficiency of the messenger to create the immune response | 03:47 |
| de-facto | assuming that the rate at which such energy thresholds occur it probably would be a rate proportional to Exp[ - Energy / k T ] with the Boltzmann constant k | 03:48 |
| DocScrutinizer05 | when you got your steak at -18°C it will last maybe a year. At -200°C it just will last a tad longer but no other effects, probably you couldn't tell by any means if it been chilled to -200°C for a week or stored at -18°C | 03:49 |
| KREYREEN | well i am concerned about what happens after exp | 03:50 |
| DocScrutinizer05 | nasically at -20°C all processes pretty much stop (for water based stuff) - further chilling doesn't change anything | 03:50 |
| DocScrutinizer05 | basically | 03:50 |
| DocScrutinizer05 | after exp? | 03:51 |
| KREYREEN | that's carbon-based afaik (gene-modified RNA) | 03:51 |
| KREYREEN | DocScrutinizer05, yep like if you are steak that has been on room temperature for 30 days then you would probably feed really bad after it | 03:51 |
| DocScrutinizer05 | look, at cooling things freeze. Once they are frozen there is nothing else that gonna happen at any lower temperature | 03:52 |
| KREYREEN | why do they want it at 80C then? | 03:52 |
| de-facto | so if we may assume a decay rate of lambda = const * Exp[ -Energy / k T] hence the rate at which the mRNA decays would gove the differential equation dN/dt = - lambda N that could easily be integrated in N(t) = N(t0) Exp[ -lambda t] hence an exponential decay for which the decay constant lambda exponentially depends on the temperature | 03:52 |
| DocScrutinizer05 | and the vaccine gets thawed before administration | 03:52 |
| KREYREEN | de-facto, i see | 03:53 |
| KREYREEN | DocScrutinizer05, how can you be sure that the vaccine gets throwed out before administration? | 03:53 |
| DocScrutinizer05 | huh? I said thawed | 03:54 |
| DocScrutinizer05 | you can't inject ice ;-D | 03:54 |
| DocScrutinizer05 | unfrozen | 03:54 |
| KREYREEN | ah i see | 03:54 |
| de-facto | that also is the reason that for a specific time the vaccine also could be kept at room temperature (i think it was like 5 days) because in that time the decay would not have decimated too much of the intact mRNA to actually still be functional | 03:55 |
| KREYREEN | de-facto, i see O.o but like how can you prevent doctors administrating drugs that were kept at room temperature after the decay or know that the vaccine that you've been given works? | 03:56 |
| de-facto | when temperature is much lower the biological half life of course also is much longer, hence for example at -80 °C it can be stored like 6 months or such | 03:56 |
| DocScrutinizer05 | on those glass viols the label always has a filed "use until __;__ o'clock" OWTTE | 03:56 |
| de-facto | the cold storage supply chain would have to be ensured by proper measures | 03:56 |
| DocScrutinizer05 | a field to hand write | 03:56 |
| KREYREEN | ah true | 03:57 |
| de-facto | i am not sure if they would put temperature indicators onto the labels or such | 03:57 |
| de-facto | probably would be a good idea to have a color field or such that decays with time just like the mRNA content in the vaccine itself | 03:58 |
| de-facto | like a "indicator" or such | 03:58 |
| de-facto | not sure if they do that though | 03:58 |
| DocScrutinizer05 | they should, but then they also should with my trimbow which only lasts 4 months outside fridge but the pharmacy seems not concerned to store in fridge like the label mandates | 03:58 |
| KREYREEN | o.o | 03:59 |
| DocScrutinizer05 | or was it 8 weeks? | 03:59 |
| DocScrutinizer05 | and the pharmacy is only the final node in supply chain | 03:59 |
| DocScrutinizer05 | I guess backaging a "OK" made from saltwater ice packed to the vaccine would go a long way, and very lowtech | 04:01 |
| DocScrutinizer05 | packaging* | 04:01 |
| DocScrutinizer05 | and obvious | 04:02 |
| de-facto | "Although the vaccine can be stored for up to 5 days at standard refrigerator temperatures once ready for use, very cold temperatures are required for shipping and longer storage. The current cold storage requirement may be alleviated by ongoing stability studies and formulation optimization, which may also be described in subsequent reports." | 04:02 |
| de-facto | .title https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 | 04:03 |
| Brainstorm | de-facto: From www.nejm.org: Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | NEJM | 04:03 |
| DocScrutinizer05 | nice OK ice -> all fine. Some (frozen) amorph puddle -> "WTF you stored it?!" | 04:03 |
| de-facto | also i am not sure what happens if it is too much degraded by temperature | 04:04 |
| ryouma | could you use saltwater ice instead of whatever they use to cool? | 04:04 |
| DocScrutinizer05 | goes basically placebo | 04:04 |
| de-facto | would it just have no effect and directly go into a cells "garbage bin"? | 04:04 |
| de-facto | yeah probably | 04:04 |
| DocScrutinizer05 | ryouma: nope, only barely -30°C achievable | 04:05 |
| de-facto | dry ice like frozen CO2 or such | 04:05 |
| DocScrutinizer05 | CO2 with acetone might suffice | 04:06 |
| de-facto | i read they even had to extend the safety limits allowed for airplane travel | 04:06 |
| de-facto | for transporting the vaccines via airplane | 04:06 |
| de-facto | again i am curious, the virions of SARS-CoV-2 also containing ssRNA being stable at room temperature longer than such vaccines? | 04:07 |
| DocScrutinizer05 | https://en.wikipedia.org/wiki/Cooling_bath#Dry_ice_baths_at_%E2%88%9278_%C2%B0C | 04:08 |
| de-facto | could such vaccines fold their mRNA around a nucleocapsid molecule to make it more stable with temperature? | 04:08 |
| de-facto | like in a helical geometry? | 04:08 |
| DocScrutinizer05 | good question | 04:08 |
| KREYREEN | What happend to the one participant that get the biotech vaccine? Apparently they had severe illness ? | 04:09 |
| KREYREEN | -- https://invidious.snopyta.org/watch?v=Beg5kiJ9DyY | 04:09 |
| ryouma | could vaccines recombine with virus? | 04:10 |
| KREYREEN | seems like the participant already caught the virus when they were administred with the vaccine from what i was able to find | 04:10 |
| KREYREEN | o.o | 04:10 |
| de-facto | %title https://www.news-medical.net/news/20200830/SARS-CoV-2-Neucleocapside-(N)-protein-is-heavily-glycosylated.aspx | 04:14 |
| Brainstorm | de-facto: From www.news-medical.net: SARS-CoV-2 Neucleocapside (N) protein is heavily glycosylated | 04:14 |
| de-facto | %title https://www.biorxiv.org/content/10.1101/2020.08.26.269043v1 | 04:14 |
| Brainstorm | de-facto: From www.biorxiv.org: SARS-CoV-2 Nucleocapsid protein is decorated with multiple N- and O-glycans | bioRxiv | 04:14 |
| de-facto | %title https://www.embopress.org/doi/full/10.15252/embj.2020105938 | 04:14 |
| Brainstorm | de-facto: From www.embopress.org: Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design | The EMBO Journal | 04:15 |
| de-facto | KREYREEN, do you have a link? | 04:20 |
| KREYREEN | de-facto, nope x.x | 04:21 |
| de-facto | i mean we are going to read about the most exotic things happening to people receiving vaccines against SARS-CoV-2 just because of the gigantic number of people receiving it the rarest things will happen. the real question will be how often it happens i.e. if its one anecdotal case or if more people will be affected | 04:25 |
| de-facto | so we should keep an eye on the side effects, but always when we get new information try to find out how often it happens, we really need to look at statistics in order to estimate the relevance for the majority of people | 04:26 |
| de-facto | for example we already now that the mRNA vaccines got quite strong reactogenicity (i.e. reactions), yet also they seem to be able to create very consistent and strong immunity, the data from the BioNTech study looks extremely good | 04:28 |
| de-facto | so the price for effective shots may be that they hurt | 04:29 |
| KREYREEN | I see O.o | 04:30 |
| KREYREEN | Why do they hurt though? because it's a big needle or? | 04:30 |
| de-facto | yet I would always happily take that for acquiring immunity against this nasty virus | 04:30 |
| de-facto | no because the immune reaction to the vaccine is strong | 04:30 |
| de-facto | actually that might even be seen as advantage, it works really well | 04:31 |
| KREYREEN | i see O.o | 04:31 |
| de-facto | like the results in immunity levels are very consistent, they dont scatter randomly but 95% confidence intervals are quite narrow | 04:32 |
| CoronaBot | 04/r/covid19: FDA Takes Key Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for First COVID-19 Vaccine (97 votes) | https://www.fda.gov/news-events/press-announcements/fda-takes-key-action-fight-against-covid-19-issuing-emergency-use-authorization-first-covid-19 | https://redd.it/kbh81q | 04:33 |
| de-facto | Cost: https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/0/nejm.ahead-of-print/nejmoa2034577/20201210-05/images/img_xlarge/nejmoa2034577_f2.jpeg | 04:33 |
| KREYREEN | I see O.o | 04:33 |
| de-facto | Benefit: https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/0/nejm.ahead-of-print/nejmoa2034577/20201210-05/images/img_xlarge/nejmoa2034577_f3.jpeg | 04:33 |
| de-facto | Consistency: https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/0/nejm.ahead-of-print/nejmoa2034577/20201210-05/images/img_xlarge/nejmoa2034577_t3.jpeg | 04:34 |
| de-facto | so just to clarify | 04:37 |
| de-facto | " Immunogenicity is the ability to induce a humoral and/or cell mediated immune response while reactogenicity is the property of a vaccine of being able to produce excessive immunological responses and associated signs and symptoms." | 04:37 |
| de-facto | so both are coupled | 04:39 |
| KREYREEN | i see | 04:47 |
| tinwhiskers | Vaccine starts rollout next week in US. that's going to make people even more complacent. Plenty of scope for things to get far far worse in the US before they get better. | 04:57 |
| de-facto | unfortunately true, people have to understand that we need non-pharmaceutical measures without exceptions until *incidence* came down to a very low level | 05:03 |
| Brainstorm | New from The Indian Express: World: US allows emergency COVID-19 vaccine in bid to end pandemic → https://is.gd/3tLeFW | 05:06 |
| de-facto | %title https://arxiv.org/abs/2011.11413 | 05:09 |
| Brainstorm | de-facto: From arxiv.org: [2011.11413] Towards a long-term control of COVID-19 at low case numbers | 05:09 |
| ryouma | where is the us prowess at propaganda when you need it? | 05:11 |
| euod[m] | I don't imagine any more than 50% of the population of the US would even consider taking the vaccine. | 05:12 |
| ryouma | idk | 05:12 |
| euod[m] | remember the pandemic is partisan. | 05:13 |
| tinwhiskers | %vax Janssen | 05:13 |
| Brainstorm | tinwhiskers, Trial start: Aug 11, Researcher: Janssen (Johnson & Johnson), Country: Belgium + USA, Participants: 91845, Vaccine: Ad26, Stage: Testing on humans | 05:13 |
| euod[m] | half the country doesn't believe it exists, or believes it's mind control, or whatever. | 05:13 |
| ryouma | idk if it's half | 05:14 |
| DocScrutinizer05 | well, that might be a good thing, if the lethality is high enough ;-D | 05:14 |
| DocScrutinizer05 | darwin at its finest. | 05:14 |
| ryouma | i don't like that kind of talk | 05:14 |
| ryouma | it doesn't apply anyway -- not everybody who gets the virus transmitted to is going to be a denier | 05:15 |
| euod[m] | right, that would be a fine way of thinking if the impact was only on people denying. | 05:16 |
| euod[m] | but the world doesn't work like that, people who refuse to be vaccinated will survive while killing people around them doing the right thing. | 05:16 |
| ryouma | just a reminder there are good reasons to decline vaccination also, such as those with known allergies to the ingredients or screwed up undiagnosed immune issues that pose a concern for such things and so on | 05:18 |
| euod[m] | yes, but nobody is actually refusing on those grounds in any number. | 05:18 |
| euod[m] | this is the same as the pieces of shit claiming they have a medical reason to not wear a mask. | 05:18 |
| ryouma | in a number. just not to the same degree as the idiots. | 05:18 |
| ryouma | my mother has problems breathing with an n95. she was grateful that i sent her what i had, which was valved. she still wears masks. but she has problems breathing with them. | 05:19 |
| ryouma | but yes there are idiots | 05:20 |
| ryouma | in VERY LARGE numbers | 05:20 |
| euod[m] | that's different to a smug piece of shit walking around walmart with their dog claiming to have a "medical exemption card". | 05:20 |
| ryouma | sure is. but needs pointing out, lest those who have problems breathing are thrown in the same category. | 05:20 |
| ryouma | there are many who don't realize some do have issues | 05:21 |
| ryouma | legitimate | 05:21 |
| CoronaBot | 04/r/coronavirus: ‘For the next 60 to 90 days we’re going to have more deaths per day than we had at 9/11,’ the C.D.C. director warned. (10324 votes) | https://www.nytimes.com/live/2020/12/11/world/covid-19-coronavirus/for-the-next-60-to-90-days-were-going-to-have-more-deaths-per-day-than-we-had-at-9-11-the-cdc-director-warned | https://redd.it/kbcv2h | 05:21 |
| ryouma | didn't 9/11 cause 1) the patriot act, which reduced freedom 2) wars? | 05:22 |
| tinwhiskers | Well that's a bit of a shame. NZ has secured enough pfizer vaccine for 750,000 people, and then enough J&J for the rest of the country in 2023, but I'm not a huge fan of the J&J (adenovirus) vaccine. | 05:23 |
| tinwhiskers | Err 2022 | 05:23 |
| ryouma | what is wrong with jj? | 05:24 |
| tinwhiskers | Well it has some good points but being an adenovirus vector people can become immune to the vector meaning it's a one-shot for covid and potentially something else down the track. | 05:25 |
| tinwhiskers | But better than nothing and it looks to be very effective | 05:25 |
| euod[m] | the australian one that uses the HIV fragments is sort of wild. | 05:26 |
| tinwhiskers | If immunity only lasts for six months or a year it may not be very effective next time round. | 05:26 |
| euod[m] | just from the perspective of it causing HIV test false positives | 05:26 |
| tinwhiskers | euod[m]: they stopped testing that one | 05:26 |
| ryouma | so you end up destroying hte vector which destroys the effectiveness of the payload? | 05:27 |
| tinwhiskers | Due to the reason you gave | 05:27 |
| euod[m] | oh yeah I know | 05:27 |
| tinwhiskers | ryouma: you become immune to the vector itself so it may not work a second time | 05:27 |
| ryouma | imagine the cosnpiuracy theories in the us with a partial hiv vector | 05:28 |
| tinwhiskers | Too early to say of course not the mRNA approach is really nice | 05:28 |
| tinwhiskers | But by the time immunity from the adenovirus vaccine wears off, hopefully more mRNA vaccines will be available. | 05:28 |
| ryouma | how does mrna get into the cells | 05:28 |
| tinwhiskers | It's just taken in by cells in the lipid that it's contained in | 05:29 |
| derpadmin | %cases us | 05:29 |
| Brainstorm | derpadmin: In US, there have been 16.3 million confirmed cases (4.9% of the population) and 302750 deaths (1.9% of cases) as of 2 hours ago. 216.9 million tests were performed (7.5% positive). Fatality can be broadly expected to lie between 1.2% (assuming prevalence as in tests) and less than 3.1% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=US for time series data. | 05:29 |
| DocScrutinizer05 | tiny lipid balls | 05:29 |
| tinwhiskers | mRNA transfer is already known to occur between cells so they have a mechanism for allowing entry. | 05:29 |
| tinwhiskers | Although, I don't think this vaccine uses that anyway | 05:30 |
| tinwhiskers | Just being a very small lipid seems to be sufficient | 05:30 |
| DocScrutinizer05 | isn't there a new segregation already in USA? I'd think the contacts between blue and red cohort are minimal, no? | 05:31 |
| Brainstorm | New from Ars Technica: Science: Head of FDA on chopping block as Trump rages over vaccine authorization [Updated] → https://is.gd/J84fNc | 05:31 |
| tinwhiskers | Possibly | 05:31 |
| ryouma | even in the us contacts between blue and red are common | 05:33 |
| tinwhiskers | There's bound to be a lot of places like shops that they mingle | 05:33 |
| euod[m] | right. | 05:33 |
| euod[m] | so even in areas with very strong separation, there's still a lot of shared infrastructure. | 05:34 |
| ryouma | all it takes is one contact | 05:35 |
| ryouma | look at tinwhiskers website. blue and red states have similar incidence right now | 05:35 |
| tinwhiskers | Really? I thought red was streaking ahead. Has that changed recently? | 05:36 |
| ryouma | on that astounding visualization with the bar charts, red did streak ahead dispositively. but that was using a different metric from your site. your site has them similar with red a bit above right now., | 05:38 |
| ryouma | it could be that the other one which uses pew data is more useful | 05:39 |
| ryouma | at the time when we created your site red and blue, the concern was more for governors as they control measures. the pew data was population which controls attitudes. | 05:40 |
| DocScrutinizer05 | hmm +28,438 | 05:48 |
| Brainstorm | New from The Indian Express: World: Donald Trump: First shot of Pfizer vaccine in US will be given in less than 24 hours → https://is.gd/WcAWPk | 05:55 |
| DocScrutinizer05 | http://reisenweber.net/et_al/covid/covid19_statistics.htm sucks | 06:04 |
| de-facto | RKI Germany: Weekly Incidence 163.8/100k, Infections +28438 (1300516), Fatalities +496 (21466 total), COVID-ICU 4448 (incl 2550 on ventilator) | 06:09 |
| de-facto | thats 14-28 fold too many infections to have it under control | 06:10 |
| de-facto | 1400% or 2800% to many we need to come down to BELOW 1000 to 2000 daily new infections | 06:11 |
| de-facto | at ANY price | 06:11 |
| de-facto | %title https://www.youtube.com/watch?v=cPbPYG3S0EI <-- RKI Briefing in German language | 06:12 |
| Brainstorm | de-facto: From www.youtube.com: Erneuter Höchststand bei Neuinfektionen - RKI-Briefing zur aktuellen Corona-Lage - YouTube | 06:12 |
| de-facto | It is out of control STILL in exponential growth in some regions and AGAIN in exponential growth at other regions | 06:13 |
| de-facto | this does not deserve the name lockdown at all | 06:14 |
| de-facto | hence again and again and again: we URGENTLY need a proper absolute STRICT Lockdown. | 06:14 |
| de-facto | and we absolutely NEED to close any school nationwide without ANY exceptions until we reach 1000 daily new infections in Germany | 06:19 |
| de-facto | its insane how this is handled right now | 06:20 |
| de-facto | (this is my standpoint not the one from RKI) | 06:21 |
| euod[m] | I expected the germans to be more.. organised. | 06:23 |
| de-facto | me too, its the ministers not cooperating with Merkel | 06:24 |
| de-facto | and to be honest i am furiously angry at them | 06:25 |
| de-facto | people need to stay at home | 06:35 |
| de-facto | %title https://www.covid-19-mobility.org/current-mobility/ | 06:35 |
| Brainstorm | de-facto: From www.covid-19-mobility.org: Current mobility · Covid-19 Mobility Project | 06:35 |
| de-facto | a mobility of -11% is not sufficient in comparison to -38% in the first lockdown | 06:35 |
| darsie | There was a guy in ##deutsch saying the RKI is lying and cv is a scam and he's banned here. | 06:39 |
| de-facto | the RKI is one of the few institutes being very honest and precise about what they say and how they say it | 06:42 |
| de-facto | i wish the ministers would listen to them | 06:42 |
| de-facto | i mean the data is all there provided in great detail by RKI | 06:49 |
| Brainstorm | Updates for Germany: +27217 cases (now 1.3 million) since 18 hours ago — Bermuda, United Kingdom: +27 cases (now 391) since a day ago — Northwest Territories, Canada: +5 cases (now 20) since 28 days ago — Curacao, Netherlands: +97 cases (now 3501), +2 deaths (now 10) since a day ago | 07:08 |
| Brainstorm | Updates for US: +255918 cases (now 16.3 million), +3070 deaths (now 302762) since 19 hours ago | 07:22 |
| de-facto | %title https://www.covid-19-mobility.org/mobility-monitor/ Mobility Data for Germany source https://rki.mobility-covid19.teralytics.net/data/de/counts.2020-12-09.csv | 07:22 |
| Brainstorm | de-facto: From www.covid-19-mobility.org: Mobility monitor · Covid-19 Mobility Project | 07:22 |
| de-facto | DocScrutinizer05, ^^ | 07:22 |
| Brainstorm | Updates for Saint Petersburg, Russia: +3779 cases (now 166942), +69 deaths (now 6178) since a day ago — Saxony, Germany: +3522 cases (now 82226), +86 deaths (now 1591) since a day ago — Rhineland-Palatinate, Germany: +1502 cases (now 54969), +32 deaths (now 837) since a day ago — Brandenburg, Germany: +972 cases (now 27283), +16 deaths (now 542) since a day ago | 07:36 |
| Brainstorm | New from The Indian Express: World: S Africa Chief Justice under fire for remarks about COVID vaccines ‘being from devil’ → https://is.gd/H80swe | 07:44 |
| de-facto | Strategy for Germany: suggestion of the Leopoldina https://www.leopoldina.org/presse-1/nachrichten/coronavirus-die-feiertage-und-den-jahreswechsel-nutzen/ https://www.leopoldina.org/publikationen/detailansicht/publication/coronavirus-pandemie-die-feiertage-und-den-jahreswechsel-fuer-einen-harten-lockdown-nutzen-2020/ https://www.leopoldina.org/uploads/tx_leopublication/2020_12_08_Stellungnahme_Corona_Feiertage_final.pdf | 07:45 |
| de-facto | %title https://science.sciencemag.org/content/369/6500/eabb9789 | 07:50 |
| Brainstorm | de-facto: From science.sciencemag.org: Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions | Science | 07:50 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | December 12, 2020: The WHO pages contain up-to-date and global information. Please refer to our Wiki for additional information. → https://is.gd/eMWy00 | 09:08 |
| Brainstorm | New from The Indian Express: World: Buhari silent on global calls to free Nigeria’s #EndSARS protesters → https://is.gd/hwjzX0 | 09:20 |
| Brainstorm | Updates for Belgium: +2762 cases (now 603159), +100 deaths (now 17792) since a day ago | 09:36 |
| Brainstorm | New from The Indian Express: World: Australia scraps COVID-19 vaccine that produced HIV false positives → https://is.gd/8lilYR | 09:44 |
| Brainstorm | New from The Indian Express: World: Italy’s staggering coronavirus toll poses uncomfortable questions → https://is.gd/n4gnMa | 10:57 |
| KREYREEN | How are pangolins relevant to SARS-CoV-2? | 11:02 |
| Brainstorm | Updates for Estonia: +757 cases (now 17713), +6 deaths (now 148) since a day ago — Switzerland: +93 deaths (now 5960) since 22 hours ago | 11:07 |
| Brainstorm | New from ProPublica: The Pandemic Hasn’t Stopped This School District From Suing Parents Over Unpaid Textbook Fees: by Ellis Simani , ProPublica, and Kim Kilbride , South Bend Tribune ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. This story was co-published [... want %more?] → https://is.gd/XmWfKN | 11:09 |
| Brainstorm | Updates for Belarus: +1975 cases (now 158334), +8 deaths (now 1254) since 21 hours ago | 12:36 |
| Brainstorm | New from The Indian Express: World: Indonesian cleric turns himself in for COVID-19 violation → https://is.gd/t6nO9H | 13:10 |
| Brainstorm | New from Gazzetta Ufficiale italiana: MINISTERO DELLA SALUTE - ORDINANZA 11 dicembre 2020: Ulteriori misure urgenti in materia di contenimento e gestionedell'emergenza epidemiologica da COVID-19. Modifica dellaclassificazione delle Regioni Abruzzo, Basilicata, Calabria,Lombardia e Piemonte. (20A06975) → https://is.gd/pYEBXr | 13:34 |
| ubLIX[m] | #bang | 13:50 |
| ubLIX[m] | oops | 13:51 |
| Brainstorm | Updates for Germany: +418 deaths (now 21832) since 22 hours ago | 13:53 |
| CoronaBot | 04/r/coronavirus: F.D.A. Clears Pfizer Vaccine, and Millions of Doses Will Be Shipped Right Away (10004 votes) | https://nyti.ms/34412Tz | https://redd.it/kbgony | 14:13 |
| Brainstorm | Updates for Switzerland: +82 deaths (now 5970) since 22 hours ago | 14:21 |
| Brainstorm | Updates for Netherlands: +9080 cases (now 603603), +53 deaths (now 10019) since a day ago — US: +251128 cases (now 16.3 million) since a day ago | 14:35 |
| kreyren[m] | Ping | 14:40 |
| Brainstorm | New from r/WorldNews: worldnews: WHO accused of conspiring with Italy to remove damning Covid report | The 102-page report said Italy’s pandemic plan had not been updated since 2006 and that, due to being unprepared, the initial response from hospitals was “improvised, chaotic and creative” → https://is.gd/Bz8Uef | 14:59 |
| Brainstorm | Updates for Eritrea: +55 cases (now 711) since 2 days ago | 16:07 |
| Brainstorm | New from r/WorldNews: worldnews: Algeria's President Tebboune mysteriously absent after Covid-19 treatment → https://is.gd/pueTAn | 16:26 |
| Brainstorm | Updates for Cyprus: +827 cases (now 14476), +5 deaths (now 75) since a day ago | 16:35 |
| Brainstorm | New from Reddit (test): CoronavirusUK: ‘Covid-19 has an odour, and the dogs are detecting it’: meet the canine super-squad sniffing out the virus → https://is.gd/WQkFO2 | 16:37 |
| Brainstorm | Updates for Denmark: +3282 cases (now 107116), +8 deaths (now 935) since 9 hours ago | 16:53 |
| Brainstorm | Updates for Albania: +879 cases (now 47742), +12 deaths (now 989) since a day ago | 17:07 |
| Brainstorm | Updates for South Carolina, US: +3572 cases (now 248798), +12 deaths (now 4685) since 21 hours ago — Italy: +19902 cases (now 1.8 million), +649 deaths (now 64036) since a day ago — Canada: +6512 cases (now 452612), +87 deaths (now 13308) since 21 hours ago — Germany: +315 deaths (now 21953) since 22 hours ago | 17:35 |
| Brainstorm | New from CNBC Health: (news): Tony Hsieh's last months are a tragic reminder of how Covid isolation can worsen mental health — here's how to help → https://is.gd/F07qIQ | 17:38 |
| Brainstorm | Updates for Arizona, US: +8077 cases (now 402589), +77 deaths (now 7322) since a day ago | 18:07 |
| DocScrutinizer05 | KREYREEN: ryouma: de-facto: >>DILUTE BEFORE USE! Discard 6h after diltution when stored at 2°C to 25°C. Dilution date and time: __.__.__ __:__<< https://i.imgur.com/pUJ0ROJ.png | 18:24 |
| DocScrutinizer05 | %paper pangolin | 18:29 |
| Brainstorm | DocScrutinizer05, 93 papers: Pangolin homology associated with 2019-nCoV by Zhigang Zhang et al, published on 2020-02-20 at http://biorxiv.org/cgi/content/short/2020.02.19.950253 [... want %more?] | 18:29 |
| DocScrutinizer05 | >>the canine super-squad sniffing out the virus<< well, about time they follow up on this | 18:33 |
| DocScrutinizer05 | you'd think a government with a brain would have thousands of police patrols with a corona sniffer dogs by now | 18:35 |
| Brainstorm | Updates for United Kingdom: +21501 cases (now 1.8 million), +520 deaths (now 64026) since 22 hours ago | 18:35 |
| DocScrutinizer05 | - a | 18:35 |
| Brainstorm | New from r/WorldNews: worldnews: Swedish Covid Workers Are Quitting, Leaving ICUs Short-Staffed → https://is.gd/ulJTMV | 18:39 |
| DocScrutinizer05 | https://www.theguardian.com/world/2020/dec/12/covid-19-has-an-odour-and-the-dogs-are-detecting-it-meet-the-canine-super-squad-sniffing-out-the-virus | 18:51 |
| Brainstorm | New from StatNews: Breaking News: First Covid-19 vaccines to arrive in states Monday, marking a pivotal moment in the pandemic response → https://is.gd/QeiaSi | 18:51 |
| Arsanerit | the first ones arrive only now? | 18:56 |
| Arsanerit | I thought the distribution had started long ago. | 18:56 |
| LjL | Arsanerit, only in the UK distribution has already started AFAIK | 18:58 |
| Arsanerit | LjL: I know that actual vaccinations have started there, but I was under the impression that regional vaccination centres had already received vaccines in various countries so they can start right away when the approval is confirmed | 19:00 |
| Arsanerit | The news here has been showing trucks physically driving vaccines around. | 19:01 |
| tinwhiskers | We don't get our Pfizer vaccine until March in NZ (assuming it makes it through MedSafe approval). | 19:01 |
| LjL | tinwhiskers, well you're less in a hurry, although you never know | 19:01 |
| Arsanerit | bbl | 19:01 |
| tinwhiskers | Arsanerit: yeah | 19:01 |
| tinwhiskers | It seems odd not to have it already delivered | 19:02 |
| tinwhiskers | Maybe there was some regulation barring that until approval was granted. | 19:02 |
| tinwhiskers | LjL: yeah, there is that | 19:02 |
| tinwhiskers | I need to find out how I can get myself into the 750K that will receive that | 19:03 |
| tinwhiskers | That's not a huge number | 19:03 |
| LjL | tinwhiskers, as opposed to...? those who don't receive any for now, or those who receive EwstraZeneca? | 19:03 |
| Brainstorm | New from Medical Xpress: US says COVID-19 vaccine to start arriving in states Monday: The nation's first COVID-19 vaccine will begin arriving in states Monday morning, U.S. officials said Saturday, after the government gave the final go-ahead to the shots needed to end an outbreak that has killed nearly 300,000 Americans. → https://is.gd/CO3cCH | 19:04 |
| tinwhiskers | LjL: both | 19:04 |
| tinwhiskers | Err, actually, those who don't receive one and then later get J&J | 19:05 |
| tinwhiskers | That won't be until third quarter of next year if I find get into the pfizer group somehow | 19:06 |
| LjL | tinwhiskers, well i guess the easiest way potentially would be to get a doctor certify that you have a lung issue | 19:06 |
| tinwhiskers | if I don't get | 19:06 |
| tinwhiskers | LjL: interesting | 19:06 |
| DocScrutinizer05 | >>Breaking News: First Covid-19 vaccines to arrive in states Monday<< vs >>vaccinations WILL start THIS weekend [quote: Trump]<< | 19:07 |
| tinwhiskers | Heh | 19:08 |
| DocScrutinizer05 | sorry, >>first vaccinations within NEXT 24h [Trump]<< | 19:09 |
| Brainstorm | New from Medical Xpress: Official: Please skip holiday gatherings as virus surges: Medical officials on Friday pleaded with people to forgo Christmas parties and large gatherings as the state faces a record-setting surge in COVID-19 cases that looks to only get worse. → https://is.gd/qWFLZH | 19:16 |
| Brainstorm | Updates for West Virginia, US: +1514 cases (now 62151), +28 deaths (now 966) since a day ago | 19:21 |
| Brainstorm | New from Medical Xpress: Unexpectedly, data show that anaesthetists and intensive care doctors are at lower risk of SARS-CoV-2: Following the first recorded death of an anaesthetist from COVID-19 in the UK in November 2020, a review of available data published in Anaesthesia (a journal of the Association of Anaesthetists) shows that unexpectedly, [... want %more?] → https://is.gd/ANvy8T | 19:28 |
| Brainstorm | New from CNBC Health: (news): Tony Hsieh's last months are a tragic reminder of how Covid isolation can worsen mental health — here's how to help → https://is.gd/F07qIQ | 19:40 |
| Brainstorm | Updates for Mauritania: +276 cases (now 10777), +12 deaths (now 222) since 21 hours ago | 20:07 |
| Brainstorm | Updates for United Kingdom: +20679 cases (now 1.8 million), +503 deaths (now 64058) since 13 hours ago — Canada: +6622 cases (now 452983), +104 deaths (now 13326) since 23 hours ago — Germany: +285 deaths (now 22018) since 23 hours ago | 20:35 |
| Brainstorm | New from r/WorldNews: worldnews: F.D.A. Clears Pfizer Vaccine, and Millions of Doses Will Be Shipped Right Away → https://is.gd/Sq4abW | 20:40 |
| LjL | good grief https://www.reddit.com/r/tifu/comments/kbp1gz/tifu_by_getting_a_covid_test/ | 20:46 |
| LjL | can we *really* not just do these on saliva instead? | 20:46 |
| genera | where did KREYREEN go? | 20:47 |
| AimHere | I saw them in #fsf bitching about #debian and freenode and trying to enlist the FSF to help them with some tedious IRC drama | 20:49 |
| genera | oh | 20:49 |
| Brainstorm | New from CNBC Health: (news): CDC panel recommends Pfizer Covid vaccine for people 16 years and older, clearing pivotal hurdle → https://is.gd/2XpJXp | 21:05 |
| Brainstorm | Updates for Delaware, US: +1058 cases (now 44876), +8 deaths (now 815) since a day ago | 21:07 |
| DocScrutinizer05 | LjL: the dangers of even doctors doing *completely incorrect and incompetent* nasal swab. You DON'T ram that swab stick up the node into the brain, sure that hurts and it's not giving a proper result. I see more often incorrect nasal swab in TV than correct ones which isinserting the swap stick into the nose direction neck, NOT upwards to "the brain" | 21:38 |
| DocScrutinizer05 | s.node.nose. | 21:38 |
| DocScrutinizer05 | damn idiots, even I know how to do it and I'm not a trained medical personal | 21:40 |
| DocScrutinizer05 | I guess I wouldn't let anybody stick anything into my nose (except a doctor specialized in this), rather do it myself. I even practiced with ordinary q-tip swabs | 21:42 |
| LjL | well i am not sure you would have a choice, if you were ordered a test | 21:45 |
| DocScrutinizer05 | I'm pretty sure THEY have no choice with me ;-D | 21:46 |
| CoronaBot | 04/r/coronavirus: Gym defying COVID-19 orders being fined nearly $10K per day (10284 votes) | https://apnews.com/1e7e5762087bc5781e8fcd180c351360 | https://redd.it/kbq4fg | 21:46 |
| DocScrutinizer05 | but yeah, they dinally should come up with a at least somewhat optimized probing procedure. I mean, this nasal swab shit is "we always did it like this since it's the most obvious way we could come up with in an experimental context" - saliva or nose wash "blow your nose into this tissue please" is just "not the classical orthodox" way and they should finally invest some time to ecaluate and optimize such alternatives | 21:50 |
| DocScrutinizer05 | evaluate* | 21:51 |
| DocScrutinizer05 | of all the existing quicktests, I think exactly ONE is using an alternative procedure | 21:52 |
| Brainstorm | Updates for Netherlands: +8888 cases (now 603891) since 20 hours ago | 21:53 |
| Brainstorm | New from CNBC Health: Pfizer’s Covid vaccine ships within hours. Here's how the U.S. plans to get it to everyone: The FDA just cleared the first Covid vaccine for emergency use. Within hours, FedEx and UPS will begin shipping 2.9 million doses across the country. → https://is.gd/ZCAzZp | 22:17 |
| Brainstorm | Updates for Syria: +130 cases (now 9041), +15 deaths (now 506) since a day ago | 22:21 |
| Brainstorm | New from CNBC Health: CDC panel recommends Pfizer Covid vaccine for people 16 years and older, clearing pivotal hurdle: A key U.S. Centers for Disease Control and Prevention panel voted unanimously to recommend Pfizer-BioNTech's Covid-19 vaccine for people 16 years and older. → https://is.gd/2XpJXp | 22:29 |
| DocScrutinizer05 | s/Pfizer’s Covid vaccine/BioNTech's Covid vaccine/g | 22:31 |
| DocScrutinizer05 | it seems USA news is just funny entertainment no matter what and who, at least as soon as somehow Trump is involved, eh? | 22:32 |
| Brainstorm | Updates for Texas, US: +49045 cases (now 1.5 million), +207 deaths (now 24489) since 21 hours ago | 22:35 |
| DocScrutinizer05 | https://medicalxpress.com/news/2020-12-americans-pfizer-vaccine-monday.html vs https://www.cnbc.com/2020/12/12/how-fedex-ups-plan-to-distribute-fda-approved-covid-vaccine-when-will-you-get-the-coronavirus-vaccine.html | 22:36 |
| Brainstorm | New from CNBC Health: Pfizer’s Covid vaccine ships within hours. Here's how the U.S. plans to deliver it: The FDA just cleared the first Covid vaccine for emergency use. Within hours, FedEx and UPS will begin shipping 2.9 million doses across the country. → https://is.gd/ZCAzZp | 22:41 |
| Pigasws | lol 3M doses | 22:42 |
| DocScrutinizer05 | hm? | 22:43 |
| Brainstorm | Updates for Canada: +7055 cases (now 454391), +117 deaths (now 13339) since a day ago | 22:52 |
| Brainstorm | New from StatNews: Health: As Covid-19 vaccines are shipped, experts appear divided on guidance for those with history of severe allergic reaction → https://is.gd/NYA1LM | 23:17 |
| Brainstorm | Updates for United Kingdom: +20696 cases (now 1.8 million) since 16 hours ago | 23:52 |
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