| Brainstorm | New from CNBC Health: (news): Here's when the Covid vaccine could be available at your neighborhood drugstore, grocery store → https://is.gd/DGcv7o | 00:21 |
|---|---|---|
| Brainstorm | Updates for Germany: +481 deaths (now 22887) since 17 hours ago — Switzerland: +138 deaths (now 6154) since 13 hours ago | 00:22 |
| de-facto | %title https://www.cogconsortium.uk/news_item/update-on-new-sars-cov-2-variant-and-how-cog-uk-tracks-emerging-mutations/ | 00:28 |
| Brainstorm | de-facto: From www.cogconsortium.uk: Update on new SARS-CoV-2 variant and how COG-UK tracks emerging mutations – COG-UK Consortium | 00:28 |
| de-facto | "The variant described today in the House of Commons contains a novel set of mutations associated with a lineage spreading rapidly in the South East of England (and more widely) that is the subject of ongoing investigations by the UK Public Health Agencies, coordinated by Public Health England and supported by COG-UK. This variant carries a set of mutations including an N501Y mutation in the receptor binding motif of the Spike protein | 00:29 |
| de-facto | that the virus uses to bind to the human ACE2 receptor." | 00:29 |
| de-facto | "S:N501 mutations have occurred multiple times in the tree, in many locations" https://nextstrain.org/groups/neherlab/ncov/S.N501?c=gt-S_501,69&p=grid&r=country | 00:30 |
| de-facto | %title | 00:30 |
| Brainstorm | de-facto: From nextstrain.org: auspice | 00:30 |
| Brainstorm | New from The Lancet (Online): [Correspondence] Making older women visible: The Editors1 illustrate how COVID-19 has made visible inequities in our society, especially the devastating impact of the pandemic on residents of long-term care homes across the world. Yet the impact of this inequity on women aged 65 years or older is missing because [... want %more?] → https://is.gd/fJ7H5x | 00:33 |
| de-facto | %title https://nextstrain.org/groups/neherlab/ncov/S.N501 | 00:34 |
| Brainstorm | de-facto: From nextstrain.org: auspice | 00:34 |
| de-facto | https://pbs.twimg.com/media/EpOyuGpXMAEuMsG?format=png | 00:35 |
| de-facto | "What do we know about S:501 mutations? S:N501Y may increase ACE2 receptor binding (work from @jbloom_lab). It is hard to extrapolate what impact that may or may not have on actual transmission or infection." | 00:37 |
| de-facto | %title https://jbloomlab.github.io/SARS-CoV-2-RBD_DMS/ <-- see "Mutant Y" | 00:37 |
| Brainstorm | de-facto: From jbloomlab.github.io: Instructions | SARS-CoV-2 RBD DMS | 00:37 |
| de-facto | "As with other mutations: it is unlikely that a few mutations render a vaccine ineffective. The vaccines under development induce antibodies to many sites on Spike, so even if one target doesn't work, others should. Still, important to investigate, as scientists are doing." | 00:40 |
| de-facto | "Dr Emma Hodcroft" https://twitter.com/firefoxx66 | 00:40 |
| de-facto | "Gupta Lab, Cambridge" https://twitter.com/GuptaR_lab | 00:45 |
| de-facto | %title https://www.medrxiv.org/content/10.1101/2020.12.05.20241927v1 | 00:45 |
| Brainstorm | de-facto: From www.medrxiv.org: Neutralising antibodies drive Spike mediated SARS-CoV-2 evasion | medRxiv | 00:45 |
| Brainstorm | New from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: December 14, 2020 → https://is.gd/iEgpT0 | 00:46 |
| de-facto | Didnt we talk about escaping mutations quite some times already here? | 00:47 |
| de-facto | Seems we might not have been that far off after all | 00:47 |
| de-facto | https://twitter.com/ewanbirney | 00:48 |
| de-facto | https://twitter.com/ewanbirney/status/1338616959437598720 | 00:48 |
| gigasu_shida | let us take time to remember that tuberculosis deaths in India still far outnumber covid deaths | 01:07 |
| de-facto | honestly that does not make it better what we are dealing with right now... | 01:20 |
| gigasu_shida | i didn't mean to use that data to make light of the situation, sorry | 01:22 |
| gigasu_shida | i was just curious and looked up tuberculosis data | 01:22 |
| de-facto | acutally many diseases that have been there before may have gotten worse because of the pandemic since medical capacities are saturated or people avoid going to hospitals or other routine vaccinations etc | 01:24 |
| ryouma | or tests | 01:25 |
| ryouma | indeed | 01:25 |
| ryouma | de-facto: they didn't say much just that there is another indication of integrationj that couold also bve an artifact | 01:26 |
| de-facto | but since non-pharmaceutical measure are not pathogen specific all the diseases with similar transmission paths to SARS-CoV-2 also are contained together with it, so for example i would not expect a big flu outbreak this winter (but thats my naive non-expert opinion) | 01:26 |
| ryouma | unless you are in a place that does not do those | 01:26 |
| de-facto | yes of course | 01:26 |
| de-facto | if just everyone could stay at home for one month, without any exception... | 01:29 |
| de-facto | but yeah thats unrealistic, people dont like to do such things | 01:29 |
| Brainstorm | Updates for France: +7917 cases (now 2.4 million) since 22 hours ago — Netherlands: +6736 cases (now 622767), +25 deaths (now 10108) since 22 hours ago | 01:36 |
| Brainstorm | New from BMJ: Covid-19: Failure to control pandemic and inequalities made England worst affected in Europe, says report: A failure to control the coronavirus pandemic, coupled with widening inequality over the past decade, has led to England having the highest rate of excess deaths from covid-19 in Europe, a new report... → https://is.gd/iCuK7a | 01:58 |
| Brainstorm | New from BBC Health: (news): Coronavirus: Health checks recommended for ethnic minorities from age 25 → https://is.gd/Sqz1bi | 02:11 |
| Brainstorm | New from BBC Health: Covid: Twelve charts on how Covid changed our lives: From cancelled operations to benefit claim rises, how has the pandemic impacted peoples' lives? → https://is.gd/Y0aFSW | 02:35 |
| LjL | <Brainstorm> New from xkcd: (news): Vaccine Tracker → https://is.gd/09XLAo | 02:46 |
| LjL | sadly "done" is not a thing it will probably ever be :( | 02:47 |
| DocScrutinizer05 | https://xkcd.com/2397/ is much better ;-D | 02:57 |
| Brainstorm | New from r/WorldNews: worldnews: Ontario family pleads for people to take COVID-19 seriously after healthy father dies → https://is.gd/cNu8rd | 03:10 |
| CoronaBot | 04/r/covid19: Sharp rise in coronavirus numbers and a new variant (80 votes) | https://www.gov.uk/government/speeches/sharp-rise-in-coronavirus-numbers-and-a-new-variant | https://redd.it/kd1m68 | 03:22 |
| CoronaBot | 04/r/coronavirus: Pfizer's CEO hasn't gotten his Covid vaccine yet, saying he doesn't want to cut in line (10053 votes) | https://www.cnbc.com/2020/12/14/pfizers-ceo-hasnt-gotten-his-covid-vaccine-yet-saying-he-doesnt-want-to-cut-in-line.html | https://redd.it/kd5duq | 04:04 |
| Brainstorm | Updates for Belgium: +1074 cases (now 609211), +103 deaths (now 18054) since 23 hours ago | 04:36 |
| Brainstorm | New from The Indian Express: World: Top US officials expected to get COVID-19 vaccine this week → https://is.gd/tgsjzD | 04:48 |
| Brainstorm | New from The Indian Express: World: Canada administers first doses of COVID-19 vaccine → https://is.gd/YN3Epr | 05:48 |
| DocScrutinizer05 | de-facto: : hey, basically R=1 for today vs -7d | 06:11 |
| de-facto | hmm it should be R=0.5 or R=0.7 or such though | 06:12 |
| DocScrutinizer05 | which feels like R<1 given the almost 30k (+25%) peek of weekend | 06:12 |
| DocScrutinizer05 | meh, we are one day _before_ shutdown | 06:13 |
| DocScrutinizer05 | a good sign | 06:13 |
| de-facto | RKI Germany: Weekly Incidence 173.7/100k, Infecitons +14432 (1351510 total), Fatalities +500 (22475 total), COVID@ICU 4678 (incl 2675 on ventilator) | 06:13 |
| DocScrutinizer05 | people preemptively reduced contacts several days ago already, it seems | 06:14 |
| de-facto | hmm and then rushed for Christmas shopping on Monday, and Today | 06:15 |
| de-facto | the Shutdown should have started right from Monday on | 06:15 |
| DocScrutinizer05 | not as much as expected | 06:15 |
| de-facto | hopefully, im still skeptical | 06:15 |
| DocScrutinizer05 | we'll see next weekend | 06:15 |
| de-facto | yeah right before Christmas, perfect timing... | 06:16 |
| DocScrutinizer05 | I guess we will see the spike from yeasterday and today, if any, on Sunday or next week Monday | 06:16 |
| DocScrutinizer05 | worse: we'll see the spike from xmess on new year | 06:17 |
| de-facto | today i have seen a long queue outside the post office on the street from people wanting to send packets | 06:17 |
| DocScrutinizer05 | seen that a 5 days ago | 06:17 |
| DocScrutinizer05 | standing the queue | 06:17 |
| de-facto | yeah I decided that this year there is no Christmas, i will not visit anyone | 06:18 |
| DocScrutinizer05 | same procedure as every year, James ;-)# | 06:18 |
| DocScrutinizer05 | at least this year I *know* there will be no open restaurants. Bitching about that is my usual xmess hobby | 06:19 |
| DocScrutinizer05 | ugh, just remembered I have to stand the Post office queue again today :-S | 06:21 |
| de-facto[m] | AstraZeneca wants to buy Alexion for 39 bln dollar | 06:51 |
| bin_bash | If you can't afford your pharmaceutical company, AstraZeneca may be able to help. | 06:55 |
| Brainstorm | New from The Indian Express: World: ‘Playing with lives’: Brazil’s COVID vaccine plan is mired in chaos → https://is.gd/7DOon8 | 07:04 |
| Brainstorm | Updates for Ontario, Canada: +2194 cases (now 146067), +20 deaths (now 3988) since a day ago — British Columbia, Canada: +2146 cases (now 42943), +49 deaths (now 647) since 3 days ago — Bermuda, United Kingdom: +40 cases (now 431) since 3 days ago — Germany: +6451 cases (now 1.4 million) since a day ago | 07:08 |
| Brainstorm | Updates for Moscow Oblast, Russia: +1484 cases (now 129305), +32 deaths (now 2505) since 23 hours ago — Baleares, Spain: +983 cases (now 27871) since 3 days ago — Lambayeque, Peru: +483 cases (now 32299), +1 deaths (now 1881) since 2 days ago — Flevoland, Netherlands: +334 cases (now 14160) since 23 hours ago | 07:36 |
| Brainstorm | New from The Indian Express: World: Half of Singapore’s migrant workers in dormitories have had COVID-19 → https://is.gd/wmN2U6 | 07:41 |
| Brainstorm | New from The Indian Express (Health): Destination of the week: Tourists in Turkey can roam freely, but locals are in lockdown → https://is.gd/coATlL | 08:17 |
| Brainstorm | New from WHO Euro: New data reveals significant gaps in influenza immunization of those who need it most in Europe: WHO set a target in 2003 that 75% of elderly people should be vaccinated against influenza each year. The most recent data (2018/2019), published this week on the European Health Information Gateway, reveals that only 1 country out of 28 [... want %more?] → https://is.gd/9Nqksg | 08:29 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | December 15, 2020: The WHO pages contain up-to-date and global information. Please refer to our Wiki for additional information. → https://is.gd/3RYNmI | 09:06 |
| Brainstorm | New from The Indian Express (Health): Life-style: Sunglass lens to clear panels: How innovators experimented with face masks → https://is.gd/4Lajoy | 09:42 |
| Brainstorm | New from Medical Xpress: Vaccines must prevent infection, progression and transmission—in every country—to truly bring COVID-19 under control: An editorial co-authored by a member of the UK's influential SAGE committee that advises the UK Government on COVID-19, and published in Anaesthesia (a journal of the Association of Anaesthetists) says that [... want %more?] → https://is.gd/JdETKb | 09:54 |
| KREYREEN | https://invidious.snopyta.org/watch?v=r2u_pz8ZRTA | 09:54 |
| Brainstorm | New from Medical Xpress: Vaccination: Study finds more than half of respondents are unlikely to get COVID-19 vaccine under emergency use authorization → https://is.gd/4uAD1y | 10:17 |
| Brainstorm | Updates for Canada: +6345 cases (now 469764) since 16 hours ago | 10:22 |
| Brainstorm | New from Medical Xpress: Germany pressing EU to speed up vaccine approval: report: Germany is pressuring EU authorities to speed up the approval of a coronavirus vaccine as it battles a surge in infections and Britain and the US begin mass inoculations, reports said Tuesday. → https://is.gd/GMe9aM | 10:42 |
| Brainstorm | New from Medical Xpress: Brazil drug agency questions 'transparency' of China vaccine: The Brazilian health regulator Anvisa on Monday accused China of using criteria that "are not transparent" to win emergency approval of its coronavirus vaccine CoronaVac, which is in the final phase of trials in Brazil. → https://is.gd/qWJazz | 10:54 |
| Brainstorm | New from Medical Xpress: Scientists show what loneliness looks like in the brain: This holiday season will be a lonely one for many people as social distancing due to COVID-19 continues, and it is important to understand how isolation affects our health. A new study shows a sort of signature in the brains of lonely people that make them distinct in [... want %more?] → https://is.gd/qQyuHG | 11:06 |
| Brainstorm | New from Medical Xpress: PM: Sweden's health officials misjudged new infection wave: Health officials in Sweden, which opted not to impose a national lockdown in response to the first wave of the coronavirus pandemic, misjudged the power of the virus's resurgence, the country's prime minister said Tuesday. → https://is.gd/D2vXmu | 11:30 |
| CoronaBot | 04/r/covid19: Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients (82 votes) | https://www.nature.com/articles/s41423-020-00604-5 | https://redd.it/kddws0 | 11:38 |
| Brainstorm | New from Medical Xpress: Poverty linked to higher risk of COVID-19 death, study suggests: People in Scotland's poorest areas are more likely to be affected by severe COVID-19—and to die from the disease—than those in more affluent districts, according to a study of critical care units. → https://is.gd/j4pvfM | 11:42 |
| Brainstorm | New from BBC Health: Covid: Keep Christmas contact to a minimum, minister warns: It comes as millions of people prepare to move into England's toughest tier of coronavirus rules. → https://is.gd/lAhefB | 11:54 |
| de-facto | ugh @ CoronaBot | 11:58 |
| de-facto | %title https://www.nature.com/articles/s41423-020-00604-5 <-- can this be another scary longcovid? how would that relate with https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1 ? | 12:05 |
| Brainstorm | de-facto: From www.nature.com: Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients | Cellular & Molecular Immunology | 12:05 |
| Brainstorm | New from Retraction Watch: Unmeet the beetles: “A very disappointing story” as authors yank paper on new insect species: Don’t tell the aquatic beetles in the family Grouvellinus Champion 1923, but their number just got a little smaller. Officially speaking, that is. Unofficially, keep that place setting at the holiday table. Well, don’t, if [... want %more?] → https://is.gd/fsBZXS | 12:06 |
| Brainstorm | Updates for Switzerland: +4271 cases (now 388828), +89 deaths (now 6185) since 18 hours ago | 12:07 |
| Brainstorm | New from BBC Health: Covid: 'Rash' Christmas rules 'will cost many lives': Two leading medical journals say the UK government's plan to ease coronavirus rules is a "blunder". → https://is.gd/lAhefB | 12:18 |
| Brainstorm | New from WHO Euro: I went out for lunch and I got vaccinated – building influenza immunity in Moscow, Russian Federation: In Moscow, capital of the Russian Federation, a woman pops out on her lunch break to be vaccinated against influenza. Summing up her experience, she simply says, “It’s convenient! I went out for lunch and I got vaccinated”. [... want %more?] → https://is.gd/1VF3ZP | 12:30 |
| Brainstorm | New from BBC Health: Covid: 'Rash' Christmas rules 'will cost many lives': Two leading medical journals say the UK's plan to ease coronavirus rules is a "blunder". → https://is.gd/lAhefB | 12:42 |
| Brainstorm | New from CNBC Health: (news): London is moving to the tightest Covid restrictions: Here's what you need to know → https://is.gd/pBkbkn | 13:18 |
| Brainstorm | New from BBC Health: Covid: 'Rash' Christmas rules 'will cost many lives': Two leading medical journals say the UK's plan to ease coronavirus rules is a "blunder". → https://is.gd/lAhefB | 13:30 |
| Brainstorm | Updates for Germany: +7410 cases (now 1.4 million), +383 deaths (now 22921) since 19 hours ago | 13:35 |
| Brainstorm | New from Medical Xpress: Customer behavior is driving pandemic distress for grocery store workers, report finds: Holiday shopping season is ramping up while COVID-19 cases are rising nationwide, presenting increased risk for essential retail workers—not just physically but mentally. → https://is.gd/e1EuQV | 13:43 |
| Brainstorm | New from BBC Health: Covid: 'Rash' Christmas rules 'will cost many lives': The UK's plan to ease coronavirus rules is a "blunder", two leading medical journals say. → https://is.gd/lAhefB | 13:55 |
| ubLIX[m] | one internal medicine doctor's severe reaction to the BioNTech/Pfizer vaccine trial results documentation: https://www.nakedcapitalism.com/2020/12/an-internal-medicine-doctor-and-his-peers-read-the-pfizer-vaccine-study-and-see-red-flags.html | 14:00 |
| Brainstorm | New from CNBC Health: (news): FDA staff report backs emergency use of Moderna's Covid vaccine in a critical step toward approval → https://is.gd/QMlg8e | 14:07 |
| Brainstorm | Updates for Sweden: +20931 cases (now 341029), +153 deaths (now 7667) since 3 days ago | 14:21 |
| Brainstorm | Updates for US: +191489 cases (now 16.9 million) since 20 hours ago | 14:35 |
| Brainstorm | New from BBC Health: FDA finds Moderna vaccine safe and effective: Moderna's vaccine is safe and 95% effective, regulators say, clearing the way for US emergency authorisation. → https://is.gd/fgAFdI | 14:44 |
| Brainstorm | New from CNBC Health: (news): FDA staff endorses emergency use of Moderna’s Covid vaccine in a critical step toward approval → https://is.gd/QMlg8e | 14:57 |
| euod[m] | yeah. no real question that christmas is going to be a disaster. | 15:11 |
| Brainstorm | New from StatNews: FDA scientists endorse Moderna Covid-19 vaccine, as documents provide new hints on efficacy: New FDA documents show preliminary evidence that Moderna's Covid-19 vaccine has some efficacy after one dose, and that it prevents asymptomatic Covid-19 cases. → https://is.gd/P2TLOo | 15:21 |
| Brainstorm | New from CNBC Health: (news): FDA staff endorses emergency use of Moderna’s Covid vaccine in a critical step toward approval → https://is.gd/QMlg8e | 15:34 |
| CoronaBot | 04/r/coronavirus: ‘I Trust Science,’ Says Nurse Who Is First to Get Vaccine in U.S. (10079 votes) | https://www.nytimes.com/2020/12/14/nyregion/us-covid-vaccine-first-sandra-lindsay.html | https://redd.it/kdcsif | 15:40 |
| Brainstorm | New from Medical Xpress: New alliance seeks to fight 'plague' of fake medicines: COVID-19 has spawned a "stark rise" in the global circulation of fake medical products relating to the pandemic, experts warn as they launch an alliance aimed at tackling the scourge. → https://is.gd/ucsSYM | 15:46 |
| Brainstorm | New from CNBC Health: (news): FDA staff endorses emergency use of Moderna’s Covid vaccine in a critical step toward approval → https://is.gd/QMlg8e | 15:58 |
| Brainstorm | New from CNBC Health: FDA staff recommends watching for Bell's palsy in Moderna and Pfizer vaccine recipients: The FDA said that there were four reported cases of Bell's palsy among Moderna's 30,000 trial participants, including three who got the vaccine. → https://is.gd/OqFNxG | 16:23 |
| Brainstorm | Updates for Netherlands: +6092 cases (now 628577), +69 deaths (now 10168) since 22 hours ago | 16:35 |
| Brainstorm | New from Medical Xpress: Forecasting the next COVID-19: Princeton disease ecologist C. Jessica Metcalf and Harvard physician and epidemiologist Michael Mina say that predicting disease could become as commonplace as predicting the weather. The Global Immunological Observatory, like a weather center forecasting a tornado or hurricane, would alert the [... want %more?] → https://is.gd/gDNeJJ | 16:47 |
| Brainstorm | Updates for Canada: +7718 cases (now 471137), +115 deaths (now 13573) since 23 hours ago | 16:53 |
| Brainstorm | New from Medical Xpress: Newly diagnosed cancer patients, especially African Americans, more at risk for COVID-19 infection: Cancer patients, especially newly diagnosed and African American patients, are significantly at risk for COVID-19 infection, hospitalization and mortality, according to a new study published in JAMA Oncology by researchers from [... want %more?] → https://is.gd/Qx3AdB | 17:00 |
| CoronaBot | 04/r/covid19: Vaccines and Related Biological Products Advisory Committee Meeting December 17, 2020 Briefing Document (80 votes) | https://www.fda.gov/media/144434/download | https://redd.it/kdl7uh | 17:04 |
| Brainstorm | Updates for Italy: +14839 cases (now 1.9 million), +846 deaths (now 65857) since 23 hours ago — Arizona, US: +4134 cases (now 424382), +64 deaths (now 7422) since 20 hours ago | 17:07 |
| Brainstorm | New from Medical Xpress: US releases new data on Moderna vaccine, paving way for approval: The US regulator on Tuesday released new data confirming Moderna's COVID-19 vaccine was safe and effective, a strong sign that it could receive emergency approval in days and be ready to roll out by next week. → https://is.gd/vlSi56 | 17:12 |
| Brainstorm | New from Medical Xpress: EU regulators move up Pfizer vaccine assessment to Dec. 21: Facing strong pressure from Germany and other European Union nations, the bloc's medicines agency on Tuesday moved up a meeting to assess the Pfizer-BioNTech coronavirus vaccine to Dec. 21, likely bringing vaccinations a step closer for millions of EU citizens. → https://is.gd/FyzGLW | 17:24 |
| Brainstorm | Updates for United Kingdom: +18450 cases (now 1.9 million), +506 deaths (now 64908) since 21 hours ago | 17:35 |
| Brainstorm | New from CNBC Health: (news): FDA staff endorses emergency use of Moderna’s Covid vaccine in a critical step toward approval → https://is.gd/QMlg8e | 17:36 |
| CoronaBot | 04/r/covid19: COVID-19 isolation having detrimental impact on children’s education and welfare, particularly the most vulnerable (82 votes) | https://www.gov.uk/government/news/covid-19-isolation-having-detrimental-impact-on-childrens-education-and-welfare-particularly-the-most-vulnerable | https://redd.it/kdle0z | 17:41 |
| Jigsy | %cases UK | 17:44 |
| Brainstorm | Jigsy: In United Kingdom, there have been 1.9 million confirmed cases (2.8% of the population) and 64908 deaths (3.4% of cases) as of 11 minutes ago. 48.2 million tests were performed (3.9% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data. | 17:44 |
| Brainstorm | New from CNBC Health: FDA staff recommends watching for Bell's palsy in Moderna and Pfizer vaccine recipients: The FDA said that there were four reported cases of Bell's palsy among Moderna's 30,000 trial participants, including three who got the vaccine. → https://is.gd/OqFNxG | 17:49 |
| Brainstorm | New from CNBC Health: (news): FDA says fatigue, headaches and muscle pain are the most common side effects of Moderna's Covid vaccine → https://is.gd/nvYPK6 | 18:02 |
| snake | is the vaccine available at rite-aid yet? | 18:02 |
| snake | just realized i will have to get it at the pharmacy since my doctor is closed | 18:02 |
| Brainstorm | New from StatNews: STAT+: STAT+ Conversations: Talking through the vaccine rollout: STAT's Helen Branswell sits down with Claire Hannan of the Association of Immunization Managers to talk through the ongoing rollout of a Covid-19 vaccine. → https://is.gd/WgsvI6 | 18:14 |
| Brainstorm | New from NPR: Some European Countries Batten Down For The Holidays With New Coronavirus Lockdowns: Amid a spike in new cases, leaders in Germany, the Netherlands and the Czech Republic have announced the return of strict measures to dissuade people from attending large holiday gatherings. → https://is.gd/IKCAFT | 18:26 |
| Brainstorm | New from Medical Xpress: WHO in talks with Pfizer, Moderna on COVID-19 vaccine access: The World Health Organization said Tuesday it is in discussions with Pfizer and Moderna about possibly including their high-tech coronavirus vaccines among early jabs for poor countries at affordable prices. → https://is.gd/VCqwwW | 18:50 |
| Brainstorm | New from Medical Xpress: Diseases, Conditions, Syndromes: Hospitals scramble to prioritize which workers are first for COVID-19 shots → https://is.gd/UcICsD | 19:02 |
| LjL | The FDA said that there were four reported cases of Bell's palsy among Moderna's 30,000 trial participants, including three who got the vaccine. ← i knew it was quite clearly not just "background incidence" | 19:07 |
| Brainstorm | New from Medical Xpress: WHO to sift Chinese samples, data in hunt for virus origins: A German scientist who is part of a small team of experts assembled by the World Health Organization to investigate the origins of the coronavirus says they plan to sift through samples and medical data from China to help determine where the bug first jumped from [... want %more?] → https://is.gd/UiG8UE | 19:14 |
| Brainstorm | Updates for Spain: +9452 cases (now 1.8 million), +388 deaths (now 48401) since a day ago | 19:21 |
| Brainstorm | New from BBC Health: Moderna vaccine safe and effective, say US experts: The analysis by US experts concludes the Moderna jab is safe, clearing the way for approval within days. → https://is.gd/fgAFdI | 19:38 |
| LjL | i'd like some safety and effectiveness with just a sprinkling of Bell's palsy, please | 19:41 |
| CoronaBot | 04/r/coronavirus: Moderna's vaccine is highly effective, FDA says, clearing way for second vaccine (10022 votes) | https://www.nbcnews.com/health/health-news/moderna-vaccine-appears-protect-against-coronavirus-infection-n1251237 | https://redd.it/kdmkbz | 19:53 |
| Brainstorm | Updates for Mauritania: +296 cases (now 11431), +8 deaths (now 236) since a day ago | 20:07 |
| Brainstorm | New from WebMD: Public Information Lacking Amid COVID Vaccine Push: What the federal government has not planned for is vaccine hesitancy, stoked -- in large part -- by social media. → https://is.gd/KDrJFP | 20:14 |
| LjL | if they didn't plan for it they were idiots, don't blame social media for something that was obvious | 20:15 |
| Brainstorm | New from r/Coronavirus: Coronavirus: [CROSSPOST] AskScience AMA Series: Got questions about vaccines for COVID-19? We are experts here with your answers. AUA! → https://is.gd/tgt1Rl | 20:50 |
| Brainstorm | Updates for Germany: +16639 cases (now 1.4 million), +510 deaths (now 23394) since 23 hours ago — Switzerland: +107 deaths (now 6261) since 20 hours ago | 20:53 |
| Brainstorm | New from Medical Xpress: Study suggests reporting of sexually transmitted infections may be impacted by COVID-19: With the health care community heavily focused on COVID-19 since the first quarter of 2020, there have been concerns that reporting of other diseases—and the resulting data that enables them to be more effectively treated and [... want %more?] → https://is.gd/KjAEWc | 21:02 |
| LjL | most of the questions in that r/AskScience AMA have "we don't know" as an answer :P | 21:07 |
| LjL | yikes https://www.ajmc.com/view/researchers-warn-of-heightened-risk-of-hiv-with-certain-covid-19-vaccines | 21:10 |
| LjL | (from this interesting question https://old.reddit.com/r/askscience/comments/kdm82i/askscience_ama_series_got_questions_about/gfxc3jg/ here, i didn't know about this slightly scary thing, but i knew about the Australian vaccine that makes you test as HIV positive) | 21:10 |
| Brainstorm | New from Medical Xpress: Telemedicine needed to diagnose and treat dysphagia in COVID-19 patients, doctors say: COVID-19 and SARS-CoV-2, the virus behind the disease, have caused health care providers to change how they treat patients. Clinicians are now frequently using telemedicine to see their patients for routine checkups, saving office visits for [... want %more?] → https://is.gd/yLiqmW | 21:14 |
| de-facto | wtf? THEIR HIV vaccine failed and therefore any other Ad5 vector based vaccine would fail in combination with HIV too? | 21:18 |
| de-facto | i dont get the rationale, is it 1) the vaccine against HIV failed and made it worse (that would be quite plausible) or 2) Do they claim any mechanism of cross reactivity from Ad5 with HIV? What if HIV positive get a cold? | 21:19 |
| de-facto | honestly the BS bells ring loudly when i read their article | 21:20 |
| de-facto | did the author even understand how vaccinations work? | 21:22 |
| de-facto | %title https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32156-5/fulltext | 21:23 |
| Brainstorm | de-facto: From www.thelancet.com: Use of adenovirus type-5 vectored vaccines: a cautionary tale - The Lancet | 21:23 |
| de-facto | i dont buy it until they show data for a NON HIV Ad5 vector vaccine having an increased infection risk for HIV. Else I would ask if they could exclude that this effect originated from their HIV antigen payload itself | 21:28 |
| de-facto | i mean obviously it failed, otherwise it would be all over the media that there would be a vaccine against HIV | 21:28 |
| bin_bash | de-facto: yeah their reasoning is odd... "this didnt work for our HIV vaccine so u might be more susceptible to HIV in the covid vaccine" | 21:32 |
| bin_bash | what a stretch without more info | 21:32 |
| bin_bash | >>Other exploratory studies have indicated that the vaccine enhances HIV replication in CD4 T cells or that Ad5-specific CD4 T cells could be more susceptible to HIV infection. | 21:32 |
| bin_bash | >the vaccine | 21:32 |
| bin_bash | which vaccine, the HIV one? That's how I'm reading it | 21:33 |
| bin_bash | why would they assume that a Covid vaccine would make you more susceptible to HIV just because of Ad5? | 21:33 |
| bin_bash | wouldn't it make more sense to think that theyd be more likely to get covid? or maybe im not understanding | 21:34 |
| bin_bash | LjL: yeah I saw the australia thing and found that so weird, which makes me wonder if it is related to this | 21:34 |
| de-facto | yeah i would think the same | 21:34 |
| Brainstorm | Updates for California, US: +35780 cases (now 1.6 million), +122 deaths (now 21212) since 23 hours ago | 21:35 |
| de-facto | them having failed with their HIV vaccine having no real reason to blame it on Ad5 without first having excluded their concept of HIV vaccine to contain the causing flaw | 21:35 |
| bin_bash | but LjL brings up a good point with the Australian vaccine and people testing + for HIV | 21:36 |
| bin_bash | such a weird cross | 21:36 |
| de-facto | yeah its because the HIV tests for parts that were employed in their vaccine platform, it does not mean they got HIV but that the test would show those fragments that occur on both 1) HIV infections 2) those using their vaccine platform (at least temporarily i guess) | 21:37 |
| bin_bash | right | 21:38 |
| bin_bash | it wasnt like the vaccine gave them HIV | 21:38 |
| bin_bash | which would be wilder | 21:38 |
| bin_bash | but i guess it triggered antibodies that the test identified as HIV antibodies? | 21:38 |
| de-facto | re Ad5 vaccine blame: so they say Ad5 prevalence is common in normal populations, how do those Ad5 antibody prevalences correlate with HIV infections? | 21:40 |
| kara[m] | can any matrix ppl not manage to join other freenode rooms? | 21:41 |
| de-facto | to be honest i even find it plausible that a vaccine against HIV could easily have the opposite effect: after all its infection of the immune cells themselves (the I in HIV), so triggering them to do the wrong thing could easily amplify infection efficiency of those immune cells i would guess (though that is speculation on my part) | 21:42 |
| de-facto | kara[m], ask in the matrix main channel, there is an IRC bridge to all of freenodes channels afaik | 21:43 |
| de-facto | some freenode channels might require registered nicknames though to be used on the irc side | 21:43 |
| de-facto | e.g. those channels that show with a +r in /MODE | 21:44 |
| kara[m] | <de-facto "some freenode channels might req"> if a registered nickname is required, does that mean a matrix bridge will not work? | 21:52 |
| Brainstorm | Updates for Netherlands: +6987 cases (now 629754) since 20 hours ago | 21:52 |
| Brainstorm | New from r/WorldNews: worldnews: Support For Scottish Independence Is Growing, Partly Due To U.K.'s COVID-19 Response → https://is.gd/pAOYMT | 22:03 |
| LjL | 14,99[21:32] 99,99 8,99bin_bash:99,99 de-facto: yeah their reasoning is odd... "this didnt work for our HIV vaccine so u might be more susceptible to HIV in the covid vaccine" | 22:05 |
| LjL | That's not what they say | 22:05 |
| LjL | Their vaccine did worse than "not working", it made you more LIKELY to get HIV | 22:05 |
| LjL | de-facto may be right that the causal link must be established better, but still, that's a quite different thing | 22:06 |
| de-facto | Difference being HIV infecting the immune cells themselves | 22:07 |
| LjL | I wrote a lot or answers to the AMA thread on Reddit but it appears they're hidden from all others | 22:08 |
| bin_bash | LjL: yes it was a hyperbolic paraphrasing but my point was it was an HIV vaccine and iirc it did use the HIV virus (but I need to check that_ | 22:08 |
| bin_bash | ) | 22:08 |
| LjL | Teaches me not to write in what's supposed to be someone else's ask ME anything platform I guess | 22:09 |
| LjL | But I thought I could since I could see the reply from at least one other non-doctor | 22:10 |
| bin_bash | ok so i must have been thinking of another trial, it doesnt look like that one used HIV at all | 22:13 |
| bin_bash | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174314/ | 22:13 |
| bin_bash | well i dont want to say at all | 22:13 |
| bin_bash | im still reading/deciphering this | 22:13 |
| de-facto | kara[m], i think the matrix bridge works for all IRC channels, but some of them (the mode +r ones) require a registered IRC nickname to be used by the matrix IRC bridge. normally it just takes the matrix user name and appends a [m] at the end or such | 22:14 |
| de-facto | the guys in the matrix main channel would know details | 22:14 |
| bin_bash | the matrix bridge does not work in my channels because i automatically ban anyone who joins with it | 22:14 |
| bin_bash | but that's not typical | 22:14 |
| de-facto | yeah of course there always are exceptions :D | 22:14 |
| Brainstorm | New from Medical Xpress: 3-D printers may be toxic for humans: Risk researchers are asking new questions about the health and safety implications and how to mitigate any potential health risks to users of 3-D printers and consumers of products manufactured with this emerging technology, especially children. Such printing is increasingly being used in [... want %more?] → https://is.gd/fXWTW6 | 22:15 |
| LjL | More importantly though, are preprinters toxic for humans? | 22:16 |
| de-facto | depends on who is printing with those pre-consensus | 22:18 |
| LjL | They better have some pre-review | 22:19 |
| de-facto | i have seen 5G papers on pubmed | 22:19 |
| de-facto | they were not meant seriously though, quite funny :D | 22:20 |
| LjL | Would 5G masts interfere with the ability of carrier pigeons to find their ways when delivering IP packets? | 22:20 |
| Brainstorm | New from Medical Xpress: US vaccine challenge: convincing skeptical African Americans: The first Americans to receive the coronavirus vaccine, live on television, were Black caregivers, optics that illustrate a daunting challenge facing the nationwide campaign: persuading skeptical African Americans to get inoculated. → https://is.gd/UcedhH | 22:27 |
| P1gassu | LjL, any take on the Pfizer vs. Moderna , re: safety | 22:54 |
| LjL | P1gassu: my bet is on pretty much identical safety profiles, except maybe for allergic reactions depending on the secondary ingredients | 22:55 |
| LjL | The very same Bell's Palsy concern seems to be coming up for both of them for one thing | 22:55 |
| LjL | I doubt that will turn out to be a coincidence in both cases | 22:55 |
| genera | biontech has sideeffects too? | 22:59 |
| LjL | That's the same as Pfizer, so... Yeah | 23:00 |
| LjL | But they're all expected to have "side effects" | 23:00 |
| LjL | It all depends on which, and how bad | 23:00 |
| genera | i thought the 4 Palsys were from modeRNA.. | 23:00 |
| LjL | No, both of them had 4 | 23:01 |
| genera | ic | 23:01 |
| LjL | Pfizer had them all in the vaccine arm | 23:01 |
| LjL | Moderna had 3 in the vaccine arm and 1 in the placebo arm | 23:01 |
| P1gassu | LjL, might it be the risk profile may not be known for 6 months, after larger numbers have been vax'd? | 23:01 |
| LjL | P1gassu: sure, at a minimum we won't know about whether this Bell's palsy thing is a real side effect or a fluke until then | 23:02 |
| P1gassu | typically, pre-vax they ask about egg allergies and advise of risk of guillan barre, but maybe thats the old process | 23:04 |
| LjL | P1gassu: that's for the flu vaccine | 23:06 |
| LjL | Egg is uninvolved in these mRNA vaccines for a start | 23:06 |
| Brainstorm | Updates for Syria: +150 cases (now 9452), +13 deaths (now 543) since a day ago | 23:06 |
| LjL | Allergies may still matter (there have been some reactions in the UK) but not to egg per se | 23:07 |
| P1gassu | am reading through this: https://www.nakedcapitalism.com/2020/12/an-internal-medicine-doctor-and-his-peers-read-the-pfizer-vaccine-study-and-see-red-flags.html | 23:07 |
| ubLIX[m] | from a position of naivety, P1gassu, it is difficult to muster an instantly realistic perspective on that article without also absorbing the scope of criticism strewn across more or less the entirety of its comment thread | 23:12 |
| LjL | P1gassu: I am not able or qualified to assess that page, but maybe you ana ask the Reddit AMA since there is actually one doctor answering there who was among the ones who voted "no" at the FDA approval for Pfizer, aiui | 23:23 |
| LjL | Since the page wants me to know that one of the people who voted "yes" was the person who wrote the glaring editorial about the Pfizer paper, that seems equitable | 23:23 |
| LjL | https://www.reddit.com/r/askscience/comments/kdm82i/askscience_ama_series_got_questions_about/ | 23:24 |
| LjL | Dr Fuller | 23:25 |
| LjL | First comment | 23:25 |
| P1gassu | I'm still reading it, but does seem risky the speed and the scope of vax'ing, are you aware of any recent vaccines that were withdrawn? I know the smallpox vax, was given to the military maybe after 9/11 | 23:28 |
| Brainstorm | New from Retraction Watch: The top retractions of 2020: Mostly, but not all, COVID-19: In what has become an annual tradition, our friends at The Scientist asked us to round up what we thought were the biggest retractions of the last 12 months. Not surprisingly, the list is dominated by some of the 39 retractions we’ve seen of COVID-19 studies. But [... want %more?] → https://is.gd/cA0I5q | 23:28 |
| LjL | This to me leads to the most important question of all, and it was again completely untouched….. How many asymptomatic patients are there? And how many who were vaccinated are still able to spread the virus? Not even an attempt to answer that question. This is critical, and is one of the ways a vaccine can backfire. If a vaccine does not provide sterilizing immunity, ie stop transmission, it is of limited use for disease control. It is great for the individual, | 23:32 |
| LjL | but if they can remain without symptoms and still spread it all around it does not help from a public health standpoint. | 23:32 |
| LjL | This is one of a few passages I can agree with. I am utterly at a loss as to why participants in Pfizer and Modern were not PCR screened, and this is one of the ways in which the "inferior" AZ vaccine had, if nothing else, a better protocol | 23:33 |
| P1gassu | interesting | 23:45 |
| LjL | uhm, i'm not very positively impressed by the r/AskScience moderation | 23:48 |
| LjL | this comment of mine https://np.reddit.com/r/askscience/comments/kdm82i/askscience_ama_series_got_questions_about/gfykw6p/ where i defend the doctors answering the question is visible to everyone | 23:48 |
| LjL | all of my other comments, where i 1) specified that i wasn't one of the doctor as a disclaimer and 2) almost always cited sources are hidden | 23:48 |
| de-facto | 10 minutes till shutdown | 23:50 |
| LjL | de-facto, there's an edit saying they've already signed off for the day | 23:51 |
| LjL | i am half thinking of replying to the people who asked the questions i answered in private messages | 23:53 |
| LjL | it actually took me a while to write those answers and grab the sources | 23:53 |
| de-facto | are the reasons for answering in private invalid by some change now? | 23:55 |
| LjL | de-facto, actually i don't know of any policy about that, i should probably look it up | 23:55 |
| LjL | ubLIX[m], fwiw, yes the cheering comments are a bit hilarious, and the whole article reads overly histrionic, but some of the things it says seem at least warranting of further investigation | 23:57 |
| LjL | although i smile a bit at the fact he hadn't actually looked at the study protocol and had to write an "UPDATE" about what he found there | 23:57 |
| LjL | his main point though is that those things should have been brought up by the editorial / peer-reviewer / editor-in-chief / FDA-advisor | 23:57 |
| LjL | and the fact that all those people are the same person is also a liiitle upsetting | 23:58 |
| ubLIX[m] | yes, indeed | 23:58 |
| ubLIX[m] | the writer is a long time commenter on that site | 23:59 |
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