| de-facto | weeks to months? | 00:07 |
|---|---|---|
| de-facto | .title https://clinicaltrials.gov/ct2/show/NCT04652102 Estimated Primary Completion Date: March 5, 2021 | 00:18 |
| Brainstorm | de-facto: From clinicaltrials.gov: A Study to Determine the Safety and Efficacy of SARS-CoV-2 mRNA Vaccine CVnCoV in Adults for COVID-19 - Full Text View - ClinicalTrials.gov | 00:18 |
| Brainstorm | New from The Lancet (Online): [Health Policy] Urgent lessons from COVID 19: why the world needs a standing, coordinated system and sustainable financing for global research and development: The research and development (R&D) ecosystem has evolved over the past decade to include pandemic infectious diseases, building on experience from multiple recent [... want %more?] → https://is.gd/WSUJcj | 00:37 |
| LjL | de-facto: so you think that Vanden Bossche guy has half a point? | 00:59 |
| Brainstorm | Updates for Germany: +6841 cases (now 2.5 million) since 23 hours ago — Canada: +4691 cases (now 893839), +44 deaths (now 22288) since 23 hours ago — Reunion: +676 cases (now 13801), +12 deaths (now 71) since 6 days ago — United Kingdom: +4133 cases (now 4.2 million) since 23 hours ago | 01:10 |
| de-facto | LjL, i havent read his stuff yet | 01:30 |
| LjL | Okay, I thought the things you posted seemed related | 01:31 |
| de-facto | yes i read the abstract but not the whole slides | 01:32 |
| de-facto | i think we should stay open minded but also on empiric base, e.g. think about how we could quantify such statements in terms of something we can measure | 01:34 |
| de-facto | and maybe we also could learn from mechanisms already observed elsewhere (question what is comparable and what not) | 01:35 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19 vaccine: 2m New Zealanders will get first dose within four months → https://is.gd/zr0nqj | 01:39 |
| LjL | de-facto: well we've never deployed a vaccine into a pandemic. I guess it's not easy to figure out what's comparable | 01:41 |
| de-facto | definitely we should have some constant monitoring on how the efficacy of the vaccine behaves as trend over time | 01:43 |
| de-facto | i think one trial publication is not enough, we need an expiry date on such results | 01:43 |
| de-facto | and that should depend on incidence | 01:44 |
| de-facto | example: dont collect cumulative trial data in Israel, rather use smaller but more time-local cohorts with exactly same endpoints after primer and plot that over time | 01:46 |
| LjL | Here the average age of hospitalized patients is going down a lot. From 60-80 to now 40-60 they said, and while it could be partly due to over 80s being vaccinated, we haven't vaccinated so many. So it could be that variants attack younger people as is often mentioned, or some other mechanism, but at least this part matches up with his claim of the third wave hitting younger people hard if we do things the way we're doing them | 01:46 |
| de-facto | if efficacy would go downwards the time derivative of it allows for extrapolating that and estimating incidence dependent window of time for the roll-out of an update | 01:47 |
| LjL | He also makes points about the short-term strength but long-term weakness of vaccines that target only the spike. I wonder if more traditional inactivated vaccines could be better in the long run, generating a mixture of antibodies to the whole virus, even if few are fully neutralizing | 01:49 |
| Brainstorm | New from BMJ: Covid-19: NHS Test and Trace made no difference to the pandemic, says report: The NHS Test and Trace service in England failed to deliver its central promise to avoid a second national lockdown and there is no clear evidence its “unimaginable” costs have been justified, MPs on... → https://is.gd/hpbUA3 | 01:50 |
| de-facto | thats an interesting point indeed, the price for the vaccines targeting highly specifically (and efficiently) the s-protein only seems to be higher likelihood of escape because of the specificity not being spread over a wide variety of more or less independent but essential parts of the virus that would need to all mutate at once (unlikely) to achieve a comparable immune escape | 01:53 |
| de-facto | example: if antibodies only target s-protein they are highly neutralizing until... that variant of the s-protein mutates away, but if there also would be antibodies against all other parts of the virus maybe such a s-protein mutant could only partly escape the more broadly spread variety of antibodies because they also bind to other (non-mutated) parts of the virions | 01:56 |
| de-facto | hence my fascination with attenuated virus vaccines (e.g. real pathogen guaranteed to be made harmless by stealing something essential from it that it cant restore on its own) | 01:57 |
| Brainstorm | Updates for France: +7173 cases (now 3.9 million) since 22 hours ago | 02:00 |
| de-facto | then a multivalent up-to-date version of that as nasal spray to go exactly the same infection path as challenge with real world pathogen scenarios | 02:01 |
| de-facto | LjL, i thought this here is quite interesting https://codagenix.com/ | 02:03 |
| de-facto | https://covidvax.org/covid19-vaccine/Codagenix/Codon-deoptimized-live-attenuated-Codagenix-Serum-Institute-of-India | 02:04 |
| LjL | i know there's that one, but it's still back at phase 1 | 02:07 |
| LjL | and i think it's the only one...? there's another that's inactivated, or so | 02:08 |
| de-facto | https://www.meissavaccines.com/ | 02:08 |
| de-facto | https://covidvax.org/covid19-vaccine/Meissa/MV-014-210-Meissa-Vaccines-INC | 02:08 |
| de-facto | and https://covidvax.org/covid19-vaccine/IndianGriffithUni/Codon-deoptimized-live-attenuated-Indian-Immunolog-Griffith-University | 02:09 |
| LjL | i see. i wonder though, using such vaccines while the "real" virus is also running rampant, isn't there going to be a risk of recombination, and ending up with something not attenuated and unexpected? | 02:10 |
| LjL | although maybe that's no worse than ending up with variants when we use the current vaccines | 02:10 |
| de-facto | i dont know, if taking a VoC (say B.1.351) and do nothing more to it than severely attenuate its replication by deoptimizing its codons (hence a LOT of point mutations but same proteins or such) why should recombination do something nasty (more virulent than the recombining live virus) then? | 02:12 |
| de-facto | yeah exactly my thought but you wrote it faster :P | 02:12 |
| de-facto | it probably would induce a "broader" (less specific to a VoC) immune response than only targeting the s-protein of that VoC | 02:14 |
| de-facto | (but hey i am not the expert on that, so take all that with a grain of salt) | 02:14 |
| Brainstorm | New from r/WorldNews: worldnews: New COVID-19 outbreak at Kelowna care home includes fully vaccinated seniors → https://is.gd/TJUAau | 02:23 |
| LjL | comment about that on reddit (the article itself doesn't give very useful information): | 02:26 |
| LjL | "At no point has it been said by Medical/Scientific community that the vaccinations stop you catching Covid. The vaccinations decrease the severity of the disease so hopefully these elderly patients will survive which would have been much less likely if they weren’t vaccinated." | 02:26 |
| LjL | what a stupid thing to write | 02:26 |
| LjL | of course the scientific community does think that vaccinations, in a majority of cases, stop you from catching COVID | 02:26 |
| LjL | the fact that *even when they don't*, they still reduce severity, is hopefully true | 02:26 |
| LjL | but now everyone seems to be able to turn the "truth about vaccines" whichever way they like | 02:27 |
| LjL | if a vaccine has 95% efficacy, by definition, it should stop the vast majority from getting COVID-19 | 02:27 |
| LjL | (which, by definition, is a symptomatic disease; simple infection from SARS-COV-2 without symptoms isn't COVID-19, so using that semantic trick doesn't hold water, either) | 02:28 |
| LjL | we already have few enough certainties, let's not destroy even the simple definitional things we have and numbers from trials | 02:28 |
| LRSN | In Israel, vaccines are almost obligatory | 02:29 |
| LjL | it's hard to make them obligatory in most other places when *we haven't got them* | 02:33 |
| LjL | Israel has paid them a lot more than we have, and surprisingly enough, they got them | 02:34 |
| LRSN | Well, they are still experimenting with the vaccine & it`s side effects... So doing this experiment on an entire population (pregnant, children, young adults etc) as lab rats is not that great | 02:37 |
| de-facto | .title https://imgur.com/a/5awmD9E https://i.imgur.com/8co1IoL.jpg | 02:45 |
| Brainstorm | de-facto: From imgur.com: SARS-CoV-2 VoC B.1.1.7 and B.1.351 neutralization evasion - Album on Imgur | 02:45 |
| LjL | "I mean, if 70% efficacy against symptoms and 100% against hospitalization and death isn't enough for someone, that's kind of crossing into germaphobia territory." (talking about J&J) | 02:45 |
| LjL | again the spurious claim that there's 100% efficacy against hospitalization and death | 02:45 |
| LjL | based on the fact that *in trials*, there were "zero people" ending up hospitalized or dead, out of... not many | 02:45 |
| LjL | now we have Israel showing that people who got the vaccine DO still get hospitalized or even die, of course at much lower rates, but no, "100%" | 02:46 |
| de-facto | LjL, indeed it looks like the convalencent plasma (recovery from natural infection) got much more variety in neutralization than the quite consistent neutralization by the vaccines | 02:46 |
| LjL | ridiculous rhetoric | 02:46 |
| LjL | de-facto, yes | 02:46 |
| de-facto | as seen in the graphic from the paper you linked yesterday | 02:46 |
| LjL | i didn't look at the graphic but it said 2.5-fold vs 10-fold | 02:46 |
| LjL | i can see the former number is lower :P | 02:46 |
| de-facto | so that would support what we just discussed about vaccines inducing much less broad more specific immunity | 02:47 |
| de-facto | also the E484K line is the worst of those point mutations by far | 02:50 |
| LRSN | Nevertheless, it seems to be the case that in 6 months or so from the second dose, you`ll have to get anther shot to maintain the antibiotics level | 02:53 |
| de-facto | so that already shows that immunologic selection pressure from vaccinated plasma probably goes into one direction while there is variety in the convalescent plasma, hence natural recovery does not only induce immunologic pressure towards the same direction | 02:53 |
| de-facto | LRSN, its not only the antibody level itself, its also the question "how well they fit" meaning their neutralization potential with currently selected and circulating VoCs | 02:54 |
| de-facto | the more variety in the antibody response the more likely some of them still fit | 02:55 |
| LjL | prepare to see this downvoted to death, so you can reinforce your dislike for Reddit if you want: https://np.reddit.com/r/Coronavirus/comments/m1ada1/take_whatever_covid_vaccine_you_can_get_all_of/gqef30i/ | 02:56 |
| de-facto | the immune system itself does some randomization (spread of variety) by itself, but it seems the vaccine s-protein variant probably is more specific compared to the dynamic immunologic response to the fight with an evolving pathogen as enemy | 02:56 |
| LRSN | de-facto So the deal would be taking a shot every 6-12 months? Is`nt that problematic for our immune system? | 02:57 |
| de-facto | i dont think its problematic for our immune system, its possible in general with other shots too (e.g. flu etc) | 02:59 |
| de-facto | the question is if we can update fast enough to stay ahead of VoCs spread, currently i have my doubts seeing how sluggishly extremely slow our vaccinaitons progress globally (as traveling still is tolerated we have to vaccinate the whole planet at once) | 03:01 |
| LRSN | The flu is not an mRNA vaccine? | 03:01 |
| LjL | hmm, do we have the Janssen study? the FDA approved it, we have data from the FDA, but did they release phase 3 data? | 03:01 |
| LRSN | the flu shot* | 03:01 |
| LjL | > maintain the antibiotics level ← antibodies. antibiotics are another thing entirely | 03:02 |
| LjL | and whether or not it's good for our immune system, we're going to have to take more vaccine shots for the rest of our lives, unless some miracle happens | 03:02 |
| de-facto | LRSN, nope but the mRNA only lasts hours to days anyhow, its the immunologic response that may exhaust the immune system for short time (probably until the first protective effects show up at ~14 days after the shots) | 03:02 |
| de-facto | LjL, nice the study i linked yesterday :) | 03:03 |
| de-facto | good question afaik the approval agencies do their own analysis of the trial data | 03:04 |
| LjL | de-facto, well because if you look at the answers i got, they're already like "i didn't mean 100% but it's 100% in the trial" | 03:04 |
| LjL | and "if no person got sick in the trial that's fine" | 03:04 |
| LjL | i wonder if these people realize how FEW PEOPLE get COVID in the vaccine arm of the trials to begin with | 03:05 |
| LjL | so i wanted to look at the data and show them the amount of people who were analyzed, but apparently there is no phase 3 out, and the link i have from the FDA only has generic information | 03:05 |
| LRSN | Israel are phase 3 :) | 03:06 |
| LjL | ? | 03:09 |
| LjL | Israel isn't a trial | 03:10 |
| de-facto | why are all the new website designs utterly bs? i cant find anything on those modern company websites | 03:10 |
| de-facto | idk what webdesigners have smoked the last decade but it definitely was not good for their mental capabilities | 03:10 |
| LRSN | LjL: Well, in the Israel-Pfizer Agreement for the vaccines, they implicitly mention it is still considered a trial | 03:12 |
| LjL | you're using a vaccine that has already completed the phase 3 trial. | 03:12 |
| LjL | a phase 4 trial is more what's going on. | 03:13 |
| LjL | https://np.reddit.com/r/Coronavirus/comments/m1ada1/take_whatever_covid_vaccine_you_can_get_all_of/gqedfld/?context=3 ← entitled US fucks is one reason *i* don't like reddit | 03:13 |
| LjL | they think reddit belongs to them and it's only ever valid to talk about the US | 03:13 |
| de-facto | i dont care about Janssen or Johnson or whatever anymore their website is complete BS | 03:14 |
| LjL | maybe it is | 03:14 |
| de-facto | there is interim results available | 03:14 |
| Raf[m] | Reddit is an American site | 03:14 |
| LjL | but i care more about, and i'll paste it here too, because i'm SICK AND TIRED of hearing "no one hospitalized" "100% effective" | 03:14 |
| LjL | There were 66 cases of COVID-19 in the vaccine group that occurred at least 28 days after vaccination and 193 cases of COVID-19 in the placebo group during this time period. Starting 14 days after vaccination, there were 14 severe/critical cases in the vaccinated group versus 60 in the placebo group, and starting 28 days after vaccination, there were 5 severe/critical in the vaccine group versus 34 cases in the placebo group. | 03:15 |
| Raf[m] | But what's the problem with taking any vaccine? I'm out of the loop | 03:15 |
| LjL | Raf[m], and freenode is under UK jurisdiction, yet we don't care | 03:15 |
| de-facto | https://translate.google.com/translate?sl=auto&tl=en&u=https://www.janssen.com/germany/covid-19-impfstoffkandidat-zwischenergebnisse-der-phase-3-studie | 03:15 |
| LjL | Raf[m], well they are not all equally effective, not even close. they have different advantages. some have advantages in the logistics and transport, and they're much cheaper, but they are also less effective. | 03:15 |
| Raf[m] | Freenode very much has a UK tilt to it, in my experience | 03:15 |
| Raf[m] | I agree | 03:16 |
| Raf[m] | So do you suggest people refuse the less effective vaccines? Or how do you approach that? | 03:16 |
| Raf[m] | J&J is less effective because it's what, 70%? | 03:16 |
| Raf[m] | Compared to mRNA based 90+% | 03:17 |
| LjL | no | 03:17 |
| LjL | i don't suggest anything | 03:17 |
| LjL | i don't give medical advice | 03:17 |
| LjL | i simply get annoyed when people oversimplify things | 03:17 |
| Brainstorm | New from r/WorldNews: worldnews: Covid: Hospitals in Brazilian cities 'close to collapse' → https://is.gd/GnnYIE | 03:18 |
| de-facto | they all are leaky towards evasive VoCs like B.1.351 or P.1 e.g. with E484K mutations | 03:18 |
| LjL | the way i approach it is that information should be transparent and truthful | 03:18 |
| LjL | and not "slanted" to convince people to take this or that vaccine | 03:18 |
| Raf[m] | True | 03:18 |
| LjL | yes, the vaccines are all kinda good against the original diseease, and probably all kinda bad against the new emerging variants | 03:18 |
| LjL | so that's one thing we can agree on, which is not very happy | 03:18 |
| LjL | but "all kinda" doesn't mean "all exactly the same", not even close | 03:18 |
| Raf[m] | And that article was posted originally from USA Today, reddit doesn't really originate ideas just propagates them | 03:19 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Documents were under the heading for the wrong vaccine, moving them ( https://github.com/ljl-covid/links/commit/5fae9ba19ace8e378214ca708b18ed67125d678e ) | 03:23 | |
| Brainstorm | Updates for Paraguay: +2125 cases (now 171985), +17 deaths (now 3360) since 23 hours ago — Germany: +283 deaths (now 72981) since 6 hours ago | 03:27 |
| Brainstorm | New from https://covid19.specops.network : ljl-covid: Documents were under the heading for the wrong vaccine, moving them → https://is.gd/si20PA | 03:29 |
| LjL | Raf[m], reddit is about discussing articles, it never claimed to originate ideas | 03:30 |
| LjL | de-facto, anyway, from your understanding of the Israel study, they actually didn't have any deaths after 7 days after the 2nd dose? in the text they just don't mention deaths except for earlier occurrences, and in Table 2, it just says "NA" | 03:32 |
| LjL | i may be missing the paragraph where it discusses that | 03:33 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Add "the" Israeli population study on the efficacy of Pfizer/BNT ( https://github.com/ljl-covid/links/commit/4fb4015ad197caa3528bcd33b86423d731987f66 ) | 03:33 | |
| LRSN | There is a lack of transparency when it comes to Israel. i.e. How many pregnant women got vaccinated? What is the number of vaccinated people who developed severe side effects after the 1/2 shot? | 03:39 |
| CoronaBot | /r/covid19: Airborne transmission of virus-laden aerosols inside a music classroom: Effects of portable purifiers and aerosol injection rates (81 votes) | https://aip.scitation.org/doi/10.1063/5.0042474 | https://redd.it/m1daf8 | 03:39 |
| Brainstorm | New from https://covid19.specops.network : ljl-covid: Add "the" Israeli population study on the efficacy of Pfizer/BNT → https://is.gd/PcttB7 | 03:39 |
| Brainstorm | Updates for United Kingdom: +4113 cases (now 4.2 million), +132 deaths (now 124799) since 23 hours ago — New Zealand: +1 cases (now 2410) since 23 hours ago | 03:40 |
| LjL | de-facto, is this why you don't like reddit? because honestly i'm about to pop an aneurysm (without even needing COVID) from responses like this https://np.reddit.com/r/worldnews/comments/m1lgti/new_covid19_outbreak_at_kelowna_care_home/gqejvg7/?context=3 | 03:55 |
| LjL | LRSN, we really lack the same information except we also lack the vaccine. | 03:59 |
| LRSN | LjL: Yeah I get what you mean, but in light of the recent findings (no transparency, almost obligatory without knowing the circumstances to full extent) I can`t see why one would want to have the vaccine | 04:02 |
| LRSN | at the moment, of course | 04:03 |
| LjL | LRSN, what makes it almost obligatory, anyway? | 04:03 |
| LjL | i can see why i would want to have the vaccine | 04:04 |
| LjL | to not get sick, and to help avoid other people (especially my parents) getting sick | 04:04 |
| LjL | if your government's lack of transparency is making you anti-vaccine, perhaps they should look at what they're doing a bit better, but also perhaps you should look at the vaccines a bit better, because i'm around people who'd *celebrate* if they could get Pfizer tomorrow | 04:05 |
| Brainstorm | New from r/WorldNews: worldnews: EU's Michel slams Britain in 'vaccine nationalism' row - The former Belgian PM hit out at the UK for blocking vaccine exports, but British government sources insist no such restrictions exist. It is the latest in a series of post-Brexit spats between London and Brussels. → https://is.gd/xVh81q | 04:13 |
| LRSN | LjL: Would they celebrate because they won`t have to quarantine anymore? or go into national/local lockdown? | 04:13 |
| LjL | no, we'd still have to respect the rules imposed, there are no exemptions for vaccinated people. | 04:14 |
| LRSN | LjL: Of course there are. Vaccinated? no quarantine, for example | 04:14 |
| LjL | if you know the rules in my country better than i do, then i guess i stand corrected | 04:15 |
| LjL | but i haven't even told you which country it is, so... | 04:15 |
| LjL | what is "quarantine" to you, anyway? i've heard this word used in a number of different ways. here, "quarantine" is typically when you are positive and have to self-isolate. | 04:16 |
| LjL | sometimes when you are a contact of a positive | 04:16 |
| LRSN | How come we are still in need to self-isolate after a positive PCR test? It is increasingly known that asymptomatic spread is not what we were told | 04:19 |
| LRSN | Too many question and contradictions regarding this whole behavior towards the pandemic & now the vaccines. | 04:20 |
| LRSN | I wish everyone the best of health, but I really don`t get the rush for vaccines - unless you are at risk, ofc | 04:21 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19: Hospitals in Brazilian cities 'close to collapse'. Health systems in most of Brazil's largest cities are close to collapse due to Covid-19 cases, a report by the country's Fiocruz institute warns. → https://is.gd/7yT7uv | 04:24 |
| LRSN | Thought we are talking about countries with vaccines. I hope you, wherever you live, will not have to deal with "Vaccines Passports" or going on a forced-vacation from work since you decided not to take the vaccine | 04:24 |
| LjL | <LRSN> How come we are still in need to self-isolate after a positive PCR test? It is increasingly known that asymptomatic spread is not what we were told ← what is this nonsense | 04:27 |
| LjL | i've had enough for today | 04:27 |
| LjL | reddit got the worst of me | 04:27 |
| LjL | don't say more of this without backing it up with a source | 04:27 |
| LjL | i'm completely out of patience | 04:27 |
| LRSN | https://wwwnc.cdc.gov/eid/article/27/4/20-4576_article | 04:32 |
| LRSN | In conclusion, our study suggests that asymptomatic cases are unlikely to contribute substantially to the spread of SARS-CoV-2. | 04:33 |
| LRSN | You had enough, sure. Thank you. | 04:34 |
| Brainstorm | New from r/WorldNews: worldnews: Alaska will be first in U.S. to offer Covid-19 vaccines to all adults → https://is.gd/gDfEVO | 04:35 |
| Brainstorm | New from The Indian Express: World: Biden’s $1.9 trillion COVID-19 package clears procedural vote in U.S. House → https://is.gd/isVNls | 04:46 |
| LjL | LRSN, the key thing there is that "Presymptomatic transmission was more frequent than symptomatic transmission" | 04:53 |
| LjL | when people say "asymptomatic" they often mean "presymptomatic", just that term is lesser known | 04:53 |
| LjL | if you do not have symptoms, people will say you're asymptomatic | 04:53 |
| LjL | but you can't predict whether you will *get* symptoms later | 04:53 |
| LjL | so your own study says that it's more frequent to have transmission from people *without* symptoms (even though they will get symptoms later) than from people *with* | 04:54 |
| LjL | so if you get a positive RT-PCR, you must isolate, since you cannot know whether you will get symptoms even though you haven't yet | 04:55 |
| LjL | "Presymptomatic transmission accounted for >75% of all transmissions to OCs in the cohort" | 04:55 |
| LRSN | "...the prior evidence that infectiousness peaks around the date of symptom onset, declining thereafter..." | 04:57 |
| LRSN | So now the conversation is not whether asymptomatic spread is an issue, but what is "presymptomatic" and what should be done. | 04:58 |
| LjL | just no. | 04:59 |
| LjL | you are not even making a point. | 04:59 |
| LjL | "presymptomatic" is effectively "asymptomatic" at the time the situation is occurring. | 05:00 |
| LjL | you can only established that retrospectively. | 05:00 |
| LjL | this started about whether you need to self-quarantine when you have a positive PCR | 05:00 |
| LjL | your own paper makes it strikingly obvious that *yes* | 05:00 |
| LjL | but you are anti-vaccine, anti-quarantine... | 05:00 |
| LjL | that is not something i'm going to put up with. | 05:00 |
| LRSN | Oh wow. lol. this was nice. Take care. | 05:01 |
| LjL | give your vaccine dose to a palestinian | 05:02 |
| LjL | since they're not even getting vaccinated | 05:02 |
| LjL | bleh | 05:02 |
| LjL | or give them to europeans, instead of snatching them with higher prices and then even complaining that you get them | 05:02 |
| CoronaBot | /r/coronavirus: Austin, Texas' fourth-largest city, keeping mask mandate despite Gov. Greg Abbott's order (10112 votes) | https://www.newsweek.com/austin-texas-fourth-largest-city-keeping-mask-mandate-despite-gov-greg-abbotts-order-1574894 | https://redd.it/m1h1xa | 05:16 |
| Brainstorm | New from The Indian Express: World: Russia to make Sputnik V vaccine in Italy, a first in EU → https://is.gd/MJNjoL | 05:19 |
| Brainstorm | Updates for Mongolia: +109 cases (now 3481) since 22 hours ago | 05:51 |
| Brainstorm | New from r/WorldNews: worldnews: Covid: Hospitals in Brazilian cities 'close to collapse' → https://is.gd/yDO7Ff | 06:13 |
| Brainstorm | New from EurekAlert!: A stronger maths foundation in first grade: First grade maths is the foundation for 12th grade maths - and for technical and business careers. Teachers can see which first graders are struggling, and where to help them, with an accurate, evidence-based, diagnostic test. The test can be helpful for teachers after Covid-19 school [... want %more?] → https://is.gd/bkNVJA | 06:24 |
| Brainstorm | New preprint: Tocilizumab efficacy in COVID-19 patients is associated with respiratory severity-based stages by Melchor Alvarez-Mon et al, made available as preprint on 2021-03-09 at https://medrxiv.org/cgi/content/short/2021.03.04.21252167 [... want %more?] | 06:59 |
| Brainstorm | Updates for Belgium: +2163 cases (now 791171), +35 deaths (now 22327) since a day ago | 07:18 |
| Brainstorm | New from The Indian Express (Health): Health: Some precautions and measures to take when heading for COVID vaccination → https://is.gd/odFqEa | 08:58 |
| -RSSBot[LjLmatrix- Feed: Firma del ‘Patto per l’innovazione del lavoro pubblico e la coesione sociale’ ( http://www.governo.it/it/articolo/firma-del-patto-l-innovazione-del-lavoro-pubblico-e-la-coesione-sociale/16372 ) | 09:08 | |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 10, 2021: The World Health Organization maintains up-to-date and global information. Please refer to our Wiki for additional information. You can find answers to frequently asked questions about Covid-19 and vaccines in our FAQ . → https://is.gd/3x8BaF | 09:08 |
| Brainstorm | New from WHO Euro: Republic of Moldova first country in Europe to receive COVID-19 vaccine through COVAX Facility: The Republic of Moldova received 14 400 doses of COVID-19 AstraZeneca vaccine on 4 March 2021, shipped via the COVAX Facility, a partnership between the Coalition for Epidemic Preparedness Innovations (CEPI), Gavi, WHO and the United [... want %more?] → https://is.gd/gEPoYM | 09:29 |
| Brainstorm | New from Medical Xpress: UK's color-blind COVID-19 vaccine strategy putting ethnic minorities at higher risk: Omitting ethnic minorities from the vaccine priority list is putting these groups at a significantly higher risk of COVID-19 illness and death. Public health doctors, writing in a commentary published by the Journal of the Royal Society of [... want %more?] → https://is.gd/jsETMq | 09:39 |
| Brainstorm | New from EMA: What's new: Medicine: Human medicines European public assessment report (EPAR): Ozurdex, dexamethasone, Macular Edema,Uveitis, Date of authorisation: 26/07/2010, Revision: 15, Status: Authorised → https://is.gd/YZj3uG | 09:50 |
| Brainstorm | New from BBC Health: (news): Covid-19: NHS Test and Trace 'no clear impact' despite £37bn budget → https://is.gd/QUIwi9 | 10:21 |
| Brainstorm | New from StatNews: First Opinion: Opinion: ‘Then the world caved in’: 7 experts describe the day they realized Covid-19 was here to stay → https://is.gd/Ma7hED | 10:42 |
| Brainstorm | New from EMA: What's new: Medicine: Veterinary medicines European public assessment report (EPAR): Purevax RC, vaccine against feline viral rhinotracheitis and feline calicivirosis, Date of authorisation: 23/02/2005, Revision: 15, Status: Authorised → https://is.gd/6w45sW | 10:53 |
| Brainstorm | New from BMJ: Severe covid-19 pneumonia: pathogenesis and clinical management: AbstractSevere covid-19 pneumonia has posed critical challenges for the research and medical communities. Older age, male sex, and comorbidities increase the risk for severe disease. For people... → https://is.gd/OWN9YC | 11:14 |
| Brainstorm | New from EMA: What's new: Medicine: Veterinary medicines European public assessment report (EPAR): Purevax RCP FeLV, Vaccine against feline viral rhinotracheitis, feline calicivirosis, feline panleucopenia and feline leukaemia, Date of authorisation: 23/02/2005, Revision: 14, Status: Authorised → https://is.gd/d9BR7E | 11:34 |
| Brainstorm | Updates for Rio Grande do Norte, Brazil: +12978 cases (now 878914), +303 deaths (now 17614) since a day ago — France: +11925 cases (now 4.0 million) since 14 hours ago — Isle of Man, United Kingdom: +87 cases (now 952) since a day ago — Lombardy, Italy: +4084 cases (now 640362), +63 deaths (now 28853) since a day ago | 11:40 |
| Brainstorm | New from The Indian Express (Health): Art and Culture: Tel Aviv’s Jewish museum reopens after $100 million upgrade → https://is.gd/LqcP7L | 12:48 |
| Brainstorm | New from BBC Health: Covid: Brazil experts issue warning as hospitals 'close to collapse': Experts fear Brazil's variants may slow down pandemic recovery, as intensive care units there fill up. → https://is.gd/4lIrpO | 13:51 |
| Brainstorm | New from Science-Based Medicine: COVID Vaccines Probably Prevent Spread: The evidence is preliminary, but it looks like the COVID vaccines do reduce the risk of spread. The post first appeared on Science-Based Medicine . → https://is.gd/zxTIdw | 14:01 |
| Brainstorm | Updates for Malta: +510 cases (now 25357), +2 deaths (now 337) since 23 hours ago | 14:04 |
| pwr22 | LjL: got a phonecall earlier whilst I was running an interview on teams | 14:17 |
| pwr22 | So had to decline it | 14:17 |
| pwr22 | Turns out it was about getting a covid vaccine and now I can't get through to the surgery | 14:18 |
| pwr22 | Got through finally, got one booked for saturday | 14:25 |
| Brainstorm | New from Medical Xpress: AstraZeneca vaccine: Careless talk has dented confidence and uptake in Europe: At the start of the year, one of the main causes of the EU's slow rollout of COVID-19 vaccines was lower than expected supplies from AstraZeneca. Fast forward a few weeks and the EU's vaccination program still trails far behind the UK and US, but [... want %more?] → https://is.gd/P3IpJl | 14:43 |
| Brainstorm | New from EMA: What's new: Medicine: Human medicines European public assessment report (EPAR): Foclivia, pandemic influenza vaccine (H5N1) (surface antigen, inactivated, adjuvanted), Influenza, Human,Immunization,Disease Outbreaks, Date of authorisation: 18/10/2009, Revision: 11, Status: Authorised → https://is.gd/nR7QVz | 15:04 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Biden urged by former FDA commissioners to pick agency chief; Lilly reports more positive data for Covid-19 drug → https://is.gd/Vss9l7 | 15:35 |
| Brainstorm | New from Emma Hodcroft: @firefoxx66: R to @firefoxx66: Additionally, we've added 5 new mutation pages & focal builds:S:L18S:Y144-S:K417S:H655S:P681ORF1a:S3675- (the deletion mentioned above)These mutations are some of those seen multiple times in variants of concern & of interest. 8/10 → https://is.gd/2wzMdh | 15:45 |
| Brainstorm | New from Scientific American: What the CDC Guidelines for Vaccinated People Mean: Infectious disease specialist Nahid Bhadelia discusses new recommendations on how vaccinated people can gather with one another and small groups of unvaccinated individuals -- Read more on ScientificAmerican.com → https://is.gd/1zdNXu | 16:06 |
| Brainstorm | New from Medical Xpress: Coronavirus one year on: Two countries that got it right, and three that got it wrong (Update): On March 11 2020, the World Health Organization declared that the COVID-19 public health emergency had become a pandemic: 114 countries were affected, there were 121,500 confirmed cases and more than 4,000 people had succumbed to the virus. → https://is.gd/OGJbq0 | 16:16 |
| Brainstorm | Updates for Germany: +7474 cases (now 2.5 million) since 19 hours ago — Switzerland: +1491 cases (now 567903), +13 deaths (now 10078) since 15 hours ago | 16:21 |
| de-facto | .title https://www.bmj.com/content/372/bmj.n579 | 16:24 |
| Brainstorm | de-facto: From www.bmj.com: Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study | The BMJ | 16:24 |
| de-facto | " The mortality hazard ratio associated with infection with VOC-202012/1 compared with infection with previously circulating variants was 1.64 (95% confidence interval 1.32 to 2.04) in patients who tested positive for covid-19 in the community. In this comparatively low risk group, this represents an increase in deaths from 2.5 to 4.1 per 1000 detected cases." | 16:25 |
| de-facto | its the B.1.1.7 VoC https://covariants.org/variants/S.501Y.V1 | 16:26 |
| de-facto | https://www.bmj.com/content/bmj/372/bmj.n579/F2.large.jpg "Fig 2: Kaplan-Meier survival curve for S gene positive (previously circulating variants) and S gene negative (new variant VOC-202012/1) participants in the UK. The y axis has been truncated as mortality was low in both groups" | 16:30 |
| Brainstorm | New from Medical Xpress: Switzerland doubles Pfizer COVID jabs order: Switzerland said on Tuesday it had bought an additional three million doses of the Pfizer/BioNTech COVID-19 vaccine, doubling the number on order to six million. → https://is.gd/hHNtu3 | 16:37 |
| Brainstorm | New from Medical Xpress: US plans to buy 100 mn more J&J COVID shots: official: President Joe Biden will announce plans Wednesday to acquire an extra 100 million doses of Johnson & Johnson's COVID-19 vaccine, giving the United States surplus capacity should other makers run into manufacturing problems. → https://is.gd/tcaVoB | 16:48 |
| Brainstorm | New from Medical Xpress: Covid cuts Italy life expectancy by almost one year: Average life expectancy in Italy has been shortened by almost one year to 82.3 years because of the coronavirus pandemic, national statistics office Istat said on Wednesday. → https://is.gd/ap5BYb | 16:59 |
| Brainstorm | New from WebMD: Pfizer’s Vaccine Plant Has History of Recalls: After nearly a decade’s worth of federal inspections, reprimands and corrective action plans, has Pfizer fixed the facility that will be filling vials of its covid vaccine? → https://is.gd/2uW43n | 17:09 |
| Brainstorm | New from Ars Technica: Science: COVID-19 could become a persistent, seasonal plague, experts warn → https://is.gd/xOvJpX | 17:20 |
| Brainstorm | New from StatNews: STAT+: Antibiotic prescribing during the pandemic raises concern about drug resistance: A new study suggests there was "very likely a considerable amount of unnecessary antibiotic prescribing among hospitalized Covid-19 patients" early in the pandemic. → https://is.gd/Xnancs | 17:31 |
| -RSSBot[LjLmatrix- Feed: Covid-19, riunione a Palazzo Chigi sulle nuove misure di contrasto alla pandemia ( http://www.governo.it/it/articolo/covid-19-riunione-palazzo-chigi-sulle-nuove-misure-di-contrasto-alla-pandemia/16376 ) | 17:33 | |
| Brainstorm | New from NPR: LA Schools, Teachers Reach Tentative Deal To Reopen Classrooms To In-Person Learning: The agreement, which still must be ratified by members of the teachers union, would see most students returning to physical classrooms for the first time in more than a year. → https://is.gd/BGZvC9 | 17:52 |
| Brainstorm | New from StatNews: Opinion: Listen: Walter Isaacson on CRISPR rivals and a Covid truce: .@WalterIsaacson joins this week's First Opinion Podcast for a wide-ranging conversation about CRISPR, patents, Covid-19, New Orleans, and more. → https://is.gd/nIZE3O | 18:03 |
| pIgAsUS | https://www.nytimes.com/2021/03/10/nyregion/nyc-jail-covid.html | 18:03 |
| LjL | pwr22: nice, good that you got through. My sister got her jab yesterday | 18:08 |
| CoronaBot | /r/covid19: Lilly's bamlanivimab and etesevimab together reduced hospitalizations and death in Phase 3 trial for early COVID-19 (83 votes) | https://investor.lilly.com/news-releases/news-release-details/lillys-bamlanivimab-and-etesevimab-together-reduced | https://redd.it/m1wky2 | 18:10 |
| LjL | I was rabid here last night. Here and on reddit. I really might need a break from all of this, even just scrolling back to your message I pass by de-facto's things confirming the variant is more deadly... Feeding myself with negativity and anger will seriously give me a heart attack without any need for covid | 18:11 |
| LjL | That Israeli guy was saying silly things but at other times I've allowed other people to expound their utter nonsense without banning them | 18:12 |
| bin_bash | hm i didnt read the whole scrollback but it seemed he was anti-vaccine AND anti-distancing which didnt make sense to me | 18:19 |
| LjL | Some very misguided understanding of asymptomatic spread not mattering | 18:29 |
| LjL | But I don't think I looked like the more rational/reasonable person in the exchange | 18:29 |
| de-facto | you are running an awesome place here, i think it connected many people worldwide to the newest findings and original sources as well as interesting discussions, tbh staying informed helps me with to deal with all the (negative) aspects of the pandemic because i personally prefer to know more details than being left in the vague | 18:34 |
| LjL | I feel like even though I know some details, the big picture is still that I see something like those Vanden Whatitwas slides, and I really don't know whether he might be right, even though it's the polar opposite of what we've been saying for ages to do | 18:36 |
| LjL | Maybe the channel is fine and the problem is just with me, actually it's most likely that way. But so I still don't know what to do about it | 18:37 |
| de-facto | i doubt there is anybody alive knowing exactly how it all will develop in the future, exactly the reason why it is so important to stay open minded towards new suggestions while at the same time being critical about upon which database claims are raised | 18:38 |
| de-facto | and also discuss about things on that basis | 18:39 |
| CoronaBot | /r/covid19: Attributes and predictors of long COVID (82 votes) | https://www.nature.com/articles/s41591-021-01292-y | https://redd.it/m1uu45 | 18:40 |
| de-facto | *being critical about upon which data and statistics claims are based | 18:40 |
| de-facto | and actually i dont know of any place that is more up-to-date than this channel here :) | 18:41 |
| Brainstorm | New from Medical Xpress: Risk for chronic kidney disease even more critical due to COVID-19 pandemic: An estimated 1 in 10 people worldwide have chronic kidney disease, but most of them don't know it. That lack of awareness is especially concerning because people with chronic kidney disease who are infected with COVID-19 are at higher risk for serious illness. → https://is.gd/RkpS5v | 18:45 |
| ReGiStRaS | Is there a central location where we have all the details reported about people who had ANY allergic reactions after receiving COVID-19 Vaccines? I think this is important knowledge that should be shared... | 18:55 |
| Brainstorm | New from Medical Xpress: You've been vaccinated for COVID-19. Now what?: The Centers for Disease Control and Prevention released new guidelines for Americans who have been vaccinated for COVID-19. Fully vaccinated people can gather safely in small groups without masks, according to the recommendations. → https://is.gd/UiRF0N | 18:55 |
| LjL | ReGiStRaS, i'd expect to find them as part of adverse reaction database, not as their own thing. VAERS for instance | 19:07 |
| Brainstorm | New from Medical Xpress: The power of mRNA, the threat of mutations and the difficulty of the last mile: When COVID-19 was declared a pandemic on March 11, 2020, even some of the most informed people knew little about coronaviruses—and far less about SARS-CoV-2, the new coronavirus that was upending the world as we knew it. → https://is.gd/2Jght5 | 19:16 |
| Brainstorm | New from In The Pipeline: Dealing With the Literature: I’ve requests from time to time to share some tips about dealing with the scientific literature. Which is indeed a problem, on several levels, and has been for a long time now. So here’s what I have to offer, and I hope it helps. A large-scale problem is what journals to even look at. I The [... want %more?] → https://is.gd/xHTN3o | 19:26 |
| Brainstorm | Updates for Italy: +22275 cases (now 3.1 million), +332 deaths (now 100811) since 22 hours ago — Isle of Man: +74 cases (now 1026) since 22 hours ago — Germany: +9849 cases (now 2.5 million) since 22 hours ago — Netherlands: +4975 cases (now 1.1 million), +40 deaths (now 15981) since 22 hours ago | 19:28 |
| Brainstorm | New from Politico: Why the UK doesn’t need a coronavirus vaccine export ban: With clever contracts and targeted investments, Britain has secured vaccine supply by other means. → https://is.gd/NLoOPo | 19:37 |
| -RSSBot[LjLmatrix- Feed: Convocazione del Consiglio dei Ministri n. 6 ( http://www.governo.it/it/articolo/convocazione-del-consiglio-dei-ministri-n-6/16379 ) | 19:38 | |
| Brainstorm | New from r/WorldNews: worldnews: UK COVID-19 variant has significantly higher death rate, study finds → https://is.gd/7RDiij | 19:47 |
| -RSSBot[LjLmatrix- Feed: Consiglio dei Ministri n. 6 ( http://www.governo.it/it/articolo/consiglio-dei-ministri-n-6/16381 ) | 19:48 | |
| Brainstorm | New from Medical Xpress: Case report looks at POTS as 'long-haul' symptom months after COVID-19 infection: Months after a COVID-19 infection, patients may experience "long-haul" symptoms like rapid heart rate, dizziness upon standing and lightheadedness consistent with a diagnosis of postural orthostatic tachycardia syndrome (POTS), according to a [... want %more?] → https://is.gd/wOs843 | 20:08 |
| LjL | de-facto, presumably this article https://www.reuters.com/article/us-health-coronavirus-variant-britain/uk-covid-19-variant-has-significantly-higher-death-rate-study-finds-idUSKBN2B213E is talking about the study you linked i.e. https://www.bmj.com/content/372/bmj.n579 ? | 20:10 |
| Brainstorm | New from Emma Hodcroft: @firefoxx66: Hey @Twitter @TwitterSupport - today's #SARSCoV2 tweet-thread from the official @nextstrain account are blocked behind 'This Tweet is Unavailable' - except the last one.There's no messages in the account & we have no idea why they aren't visible. Can someone help please? → https://is.gd/Zi1Xod | 20:19 |
| Brainstorm | Updates for France: +27749 cases (now 4.0 million), +294 deaths (now 89524) since 23 hours ago | 20:29 |
| Brainstorm | New from Gazzetta Ufficiale italiana: MINISTERO DELLA SALUTE - ORDINANZA 9 marzo 2021: Ulteriori misure urgenti per la sperimentazione di voli Covid-tested.(21A01552) → https://is.gd/fRCtmG | 20:29 |
| de-facto | came out today | 20:38 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Add UK study showing the B.1.1.7 variant has 1.64 mortality risk ( https://github.com/ljl-covid/links/commit/c236022e15dc4e5b08f437b1e518daf2586918d0 ) | 20:38 | |
| LjL | i'm starting to think github's markdown is kind of inadequate to keep all these links | 20:39 |
| Brainstorm | New from https://covid19.specops.network : ljl-covid: Add UK study showing the B.1.1.7 variant has 1.64 mortality risk → https://is.gd/pP2DdD | 20:40 |
| LjL | there are things that fit into more than one category, the stuff about the UK variant is all in one bullet point that's becoming long as hell | 20:40 |
| LjL | maybe i need something like https://www.zotero.org/ but also with a web server | 20:40 |
| de-facto | so that means for every 3 COVID deaths caused by infection with the D614G variant we would have to expect ~5 fatal outcomes when the infection was caused by the B.1.1.7 VoC of SARS-CoV-2 | 20:41 |
| LjL | de-facto, yes, so much for "it will get weaker, they always do when they get more infectious" (heard SO often as dogma). but even when you have a study like this, someone manages to twist it to mean that there is barely any mortality: https://www.reddit.com/r/worldnews/comments/m24pi3/uk_covid19_variant_has_significantly_higher_death/gqhdcgp/ | 20:43 |
| de-facto | I always rejected that assumption that we can assume (in general) that SARS-CoV-2 would become more mild (because i think it depends on the point of disease progression where most infections are caused by a carrier) | 20:45 |
| LjL | i know | 20:46 |
| LjL | but it seems like fighting against people who go "la la la i can't hear you" | 20:46 |
| LjL | you see my comment was already downvoted? that person said something extremely superficial, i explained why it was wrong without insulting or anything, but with data from the study | 20:46 |
| CoronaBot | /r/coronavirus: Alaska makes vaccines available to those 16 and older, becoming first state to remove eligibility requirements (10144 votes) | https://www.washingtonpost.com/health/2021/03/09/alaska-covid-vaccine-16-and-older/ | https://redd.it/m1wlpl | 20:47 |
| de-facto | if its pre-symptomatic the pathogen can mutate towards more severe progressions without harming its replication in a population, at least as long as it becoming more dangerous does not give raise to more severe containment efforts | 20:47 |
| LjL | but people hate to hear what they don't want to hear | 20:47 |
| de-facto | yes of course | 20:47 |
| LjL | and this is worldnews, but r/COVID19 which is supposed to be strictly scientific had an upvoted comment that was just wrong, and the people correcting it were wondering why they were getting downvotes | 20:48 |
| LjL | (on the same study) | 20:48 |
| LjL | here https://www.reddit.com/r/COVID19/comments/m1ume1/risk_of_mortality_in_patients_infected_with/gqfobxn/ (although by now luckily the votes have changed a bit) | 20:49 |
| LjL | obviously it makes no sense to make a "but the VOC happened during healthcare stress period" objection, if the cohorts were compared *during the same period* | 20:50 |
| LjL | and yet, 10 presumably scientifically-minded people agreed with this objection | 20:50 |
| LjL | anyway, i got the Zotero suggestion from this post https://blogs.sciencemag.org/pipeline/archives/2021/03/10/dealing-with-the-literature which is not about COVID in particular but Derek Lowe saying how he tries to sort through the very many scientific papers that get posted | 20:52 |
| LjL | he starts by saying he uses RSS, duh :P | 20:52 |
| de-facto | nice | 20:54 |
| Arsanerit | Does a virus have any evolutionary advantage in mutating towards more severe progressions? | 20:54 |
| LjL | Arsanerit, yes, it is often connected to reproducing more | 20:56 |
| LjL | if you make more virus, it tends to mean you disrupt the host's cells more | 20:56 |
| LjL | which it turn means the progression is quicker and more severe | 20:56 |
| LjL | which means the person may die before infecting others | 20:57 |
| de-facto | LjL, https://en.wikipedia.org/wiki/Comparison_of_reference_management_software | 20:57 |
| LjL | which means the virus may want to reproduce a bit less, because it will eventually make it reproduce more | 20:57 |
| LjL | so it's a compromise | 20:57 |
| Arsanerit | I see. Thank you for the explanation. | 20:57 |
| LjL | but there are additional complications, such as *when* does the severe progression happen? | 20:57 |
| LjL | this particular virus is mostly infectious before symptoms | 20:57 |
| LjL | so after symptoms starts, it mostly doesn't *care* whether it's severe or not | 20:58 |
| LjL | if it accrues a mutation that helps it, but it also happens to make the disease more severe later, it is not penalized, because it's "later" | 20:58 |
| LjL | de-facto, seems like Zotero is the only open source one with a recent release, at least unless the wikipedia article is not very updated | 20:59 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: This is an adorable COVID-19 vaccines video.https://youtu.be/G3MJJKcJVJQ → https://is.gd/PGXV3H | 21:01 |
| LjL | Zotero looks good, it has a plugin for Firefox, you just click on the icon and the paper ends up in Zotero and then you can add tags to it or sort it into folders | 21:03 |
| de-facto | thats neat :) | 21:04 |
| LjL | although https://www.zotero.org/blog/a-unified-zotero-experience/ bah firefox :( | 21:05 |
| Brainstorm | New from r/WorldNews: worldnews: German coronavirus vaccine inventor being investigated: Physician Winfried Stöcker developed and produced a coronavirus vaccine in his lab and administered it to volunteers — without getting it approved first. Criminal proceedings against him are now underway → https://is.gd/W4ca8c | 21:11 |
| de-facto | hmm but its on their website or what? i would not like to depend on any external servers | 21:21 |
| -RSSBot[LjLmatrix- Feed: Visita di Draghi al centro vaccinale anti Covid dell’aeroporto di Fiumicino ( http://www.governo.it/it/articolo/visita-di-draghi-al-centro-vaccinale-anti-covid-dell-aeroporto-di-fiumicino/16382 ) | 21:28 | |
| Brainstorm | New from Medical Xpress: Pediatrics: What parents should know about rare but scary COVID-19-related illness → https://is.gd/qhcSPQ | 21:43 |
| whytek | LjL, in relation to your first interventions today, I was going to ask you if you knew about hackingwithcare | 21:59 |
| whytek | which is something that kind of grew out of the meeting up of two activists, one also a massage enthusiast and the other an intense computer user networker/activist. | 22:00 |
| whytek | I see that the website, hackingwithcare.in now has got a bunch of less "relaxing" stuff on it, but all the same.. it's good to remember to take a break. you don't always have to engage, you can't FIX it. (all) | 22:01 |
| whytek | Anyway, it's still good work.. I would ask though, why ##covid-19 and ##coronavirus ? | 22:02 |
| Brainstorm | New from Politico: Coronavirus: EU to extend vaccine export restrictions until June → https://is.gd/QQX8f2 | 22:03 |
| LjL | whytek: thanks... although indeed the content there looks pretty unrelaxing overall :D I think partly I've created this channel to have a sense of control over it. Obviously I can't fix it or even marginally contribute to foxing it, rationally, but a sense of control helps. But then if I get too invested that sense of control turns again into utter brain chaos | 22:07 |
| LjL | The two channels mainly exist separately because they were created without knowing about each other | 22:08 |
| LjL | At this point I think if it ain't broke, don't fix it. Plus there are practical differences that would make merging complicated, like the fact this one is also a Matrix room | 22:09 |
| LjL | Slightly different takes on channel content, too, but overall we're on friendly terms and a lot of people are in both | 22:09 |
| Brainstorm | New from Medical Xpress: AstraZeneca vaccine not to blame for Austria death: EMA: Europe's medicines watchdog said Wednesday a preliminary probe showed that a batch of AstraZeneca vaccines used in Austria was likely not to blame for the death of a nurse who received a jab. → https://is.gd/JuWMxu | 22:14 |
| Brainstorm | Updates for Germany: +7006 cases (now 2.5 million) since 21 hours ago — Canada: +2806 cases (now 896645), +31 deaths (now 22319) since 21 hours ago — Netherlands: +4957 cases (now 1.1 million) since 21 hours ago | 22:35 |
| Brainstorm | New from Shane Crotty: @moderna_tx: RT by @profshanecrotty: We just announced that the first participants have been dosed with our modified COVID-19 vaccines, designed to address the potential need for booster vaccine candidates, in an amendment to the ongoing Phase 2 clinical study. Read more: https://buff.ly/38t7DZO → https://is.gd/6X18UZ | 22:55 |
| de-facto | LjL, seems they have it open source, so maybe not dependent on their servers? not sure... https://github.com/zotero/dataserver | 22:57 |
| LjL | de-facto: I would probably use their server, they have free accounts, I don't really want to maintain another online thing like that... Also while Zotero seems good for papers, on github I also have things that aren't papers (although tbh the majority is papers). So I may make a repository of just papers on Zotero to search more quickly when I need to find a paper, and make it public. If you look at "Groups" in the Zotero website and then search for a random | 23:01 |
| LjL | public group and try using it, it will mostly look like a HTML version of the local Zotero program (try searching for covid) | 23:01 |
| * LjL suddenly remembers reading something about 2-layer cloth masks blocking most droplets but causing aerosolized particles to be released, while 3-layer would block almost everything, and as usual when I remember things vaguely like that, I get anxiety about where did I read it, can I find it again, am I getting confused... | 23:05 | |
| de-facto | i dont know, there are many of such softwares, most half free half proprietary, it may have advantages to have interfaces to publishers, but also comes with depending on their services | 23:05 |
| LjL | If that were true then some 2 layer cloth masks may do more harm than good | 23:05 |
| de-facto | yeah sometimes i go ahead and grep the logs, but thats not optimal | 23:05 |
| LjL | de-facto: Zotero interfaces with publisher websites by modules written by the community that basically scrape the information, aiuo | 23:06 |
| LjL | Aiui | 23:06 |
| LjL | Grepping the logs is my goto but only it's baffling | 23:06 |
| LjL | I assume something will be easily findable but it's not | 23:06 |
| LjL | This sensation of vaguely knowing something but not know how to find it again definitely doesn't help with the sense of control I mentioned earlier | 23:07 |
| LjL | There's so much stuff | 23:07 |
| Brainstorm | Updates for Spain: +234 deaths (now 71961) since a day ago | 23:13 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: This is an excellent COVID-19 vaccines efficacy explainer, for anyone who wants some nuance. https://www.bloomberg.com/news/articles/2021-03-10/what-s-the-best-covid-vaccine-why-it-s-not-so-simple-quicktake?sref=VCvLK5dI@jwgale → https://is.gd/Aimmhh | 23:16 |
| de-facto | indeed, it would be nice to have some powerful search and reference tool | 23:17 |
| LjL | In so many cases Brainstorm can't even extract titles the way a browser sees them ;( | 23:20 |
| LjL | %tr <it Torna a superare la soglia critica del 30% sul totale dei posti letto disponibili il numero dei pazienti Covid-19 ricoverati in terapia intensiva (dati dell’Agenzia nazionale per i Servizi sanitari regionali aggiornati alla sera del 9 marzo 2021). | 23:32 |
| Brainstorm | LjL, Italian to English: The number of Covid-19 patients admitted to intensive care (data from the National Agency for Regional Health Services updated on the evening of March 9, 2021) returns to the critical threshold of 30% of the total number of beds available. (MyMemory) [... want %more?] | 23:32 |
| LjL | %tr <it Tre aziende italiane produrranno il vaccino russo Sputnik: la Adienne Pharma&Biotech ha firmato un accordo per avviare la produzione già da luglio. Altre due società «ai blocchi di partenza». Per Bruxelles lo Sputnik non rientra «nella strategia Ue» e la produzione in Italia «è irrilevante». | 23:43 |
| Brainstorm | LjL, Italian to English: Three Italian companies will produce the Russian Sputnik vaccine: Adienne Pharma&Biotech has signed an agreement to start production as early as July. Two other companies 'at the starting blocks'. For Brussels, Sputnik is not 'part of the EU strategy' and production in Italy 'is irrelevant'. (MyMemory) [... want %more?] | 23:43 |
| LjL | de-facto: the EU is unhappy we're turning to Sputnik... Maybe we wouldn't have if their own contracts were enforced/enforceable, uh? Right now Biden is announcing they're buying another 100 million J&J doses, while, guess what, J&J told Europe there will be a cut in doses sent to us. I feel like I've heard that story before | 23:45 |
| de-facto | we should never depend on US or UK companies, they are not reliable. | 23:50 |
| de-facto | we should invest into our own production capacity, thats the only sane thing to do | 23:51 |
| Arsanerit | should have done than 9 months ago | 23:56 |
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