| de-facto | only that it seems the first sequence we have seen already seems to had some time to optimize to human cells | 00:00 |
|---|---|---|
| de-facto | Arsanerit, gn8 | 00:00 |
| de-facto | also its astonishing that SARS-CoV-2 can change so much in terms of immune system escape with so few mutations | 00:02 |
| de-facto | afaik the B.1.351 VoC or the P.1 VoC might have evasion capability equivalent to SARS-CoV-1 | 00:03 |
| de-facto | e.g. neutralization was as much lower compared to D614G antibodies as if those VoCs would have been SARS-CoV-1 | 00:04 |
| LjL | de-facto, to D614G antibodies, or to monoclonal antibodies / vaccine antibodies? | 00:11 |
| de-facto | i am not entirely sure | 00:12 |
| de-facto | i have seen it in one of the more recent papers hence i guess something with vacc | 00:13 |
| de-facto | dangit this codon-deoptimization tech is really awesome | 00:13 |
| de-facto | its so damn cool what is possible | 00:14 |
| de-facto | for example the CureVac vaccine uses codon optimization to create a folding of the RNA that is more stable | 00:14 |
| de-facto | at least that is how i understand it | 00:14 |
| de-facto | (i hope i am not wrong about that) | 00:14 |
| de-facto | so that makes it more stable at less cooling temp | 00:15 |
| de-facto | or the codon-deopt for those vaccines, can slow down translation, and even mutation rates at specific locations | 00:15 |
| de-facto | so it seems with the different ways to express the same end result (protein) with a RNA sequence one can encode quite some significantly different properties | 00:16 |
| de-facto | properties at translation and replication time that is | 00:16 |
| de-facto | .title https://covid19.trackvaccines.org/vaccines/98/ | 00:18 |
| Brainstorm | de-facto: From covid19.trackvaccines.org: Meissa Vaccines Inc: MV-014-212 – COVID19 Vaccine Tracker | 00:18 |
| de-facto | LjL, look another vaccine tracker ^^ | 00:18 |
| de-facto | Canada | 00:19 |
| LjL | very good | 00:19 |
| LjL | it has RSS feeds too | 00:19 |
| LjL | ah, nevermind, the RSS feeds are kinda fake | 00:21 |
| LjL | but still good | 00:21 |
| LjL | de-facto, https://covid19.trackvaccines.org/how-do-vaccines-work/#types is a simple but useful chart | 00:22 |
| LjL | strange, https://covid19.trackvaccines.org/trials-vaccines-by-country/ lists three international agencies... obvious the WHO is there, but the EMA isn't | 00:24 |
| de-facto | yes i like their structuring, its very intuitive | 00:25 |
| de-facto | hmm yeah | 00:26 |
| de-facto | strange | 00:26 |
| LjL | what do you think of the idea of highlighting certain entries in my list in bold, like important entries that cover a field generally, so things like this site, covidvax, and also outbreak.info, nextstrain...? | 00:26 |
| de-facto | everything making a structure more visible is a good idea imho | 00:29 |
| de-facto | maybe also with css classes or such? | 00:29 |
| de-facto | than you could change color or text weight etc independently | 00:30 |
| de-facto | e.g. for each category represented by a css class | 00:30 |
| LjL | it's markdown... even if i can somehow use css classes in that, i think it would be a bit of a mess | 00:31 |
| LjL | i think if we want to make a list with extensive categorizing and tags we should use the "cloud" based Zotero stuff | 00:32 |
| LjL | although i'm not sure if the free 300MB are enough to hold the PDFs of the studies | 00:32 |
| LjL | but we don't really need to *embed* the PDFs. i don't know if it's possible to opt out of that, and just have links | 00:33 |
| LjL | anyway i'm not really sure i have it very clear in my mind which links deserve bolding | 00:34 |
| LjL | it may end up being annoyingly many | 00:34 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Add https://covid19.trackvaccines.org/ as another good vaccine tracker ( https://github.com/ljl-covid/links/commit/1cff92e4c95ad0bdb5451d294244daf593996802 ) | 00:34 | |
| de-facto | but just calculated if B.1.1.7 is 164% as fatal as D614G it means that it is as fatal as if the infected individual (with B.1.1.7) would be 4.1 years older but infected with D614G instead | 00:37 |
| LjL | meh i won't do the bolding thing for now. the page really looks a bit overwhelming, but the pages i'd end up bolding are really just the first bunch of pages in each category (and if not, i should probably move them to the top) | 00:38 |
| de-facto | hence an increase in fatality by 164% is equivalent with an age increase of 4.1 years | 00:38 |
| LjL | i'm not sure if that's reassuring or scary | 00:38 |
| Brainstorm | New from https://covid19.specops.network : ljl-covid: Move travel sites down, as their importance is currently minor → https://is.gd/UMBc1q | 00:39 |
| de-facto | a simple mutation making your immunological age 4.1 years older is quite scary imho | 00:39 |
| -RSSBot[LjLmatrix- Recent Commits to links:master: Move travel sites down, as their importance is currently minor ( https://github.com/ljl-covid/links/commit/49ee262ec3367018efc9fc1fb63c096794712524 ) | 00:39 | |
| LjL | de-facto, well it's not just one mutation, is it | 00:42 |
| de-facto | yeah | 00:46 |
| de-facto | did not get too much sleep :D | 00:46 |
| LjL | Twitter really is something i should just use for up to date virologist thoughts, and earthquakes | 00:51 |
| LjL | i made a comment on astrazeneca and already got replies that don't make sense | 00:51 |
| LjL | including "Well aren't you lucky you haven't had this vaccine yet then." | 00:52 |
| LjL | how does this person know what vaccines i have or haven't had? O.o | 00:52 |
| LjL | creepy! | 00:52 |
| de-facto | you know at some stage social networks know more about you than you know about yourself :D | 00:54 |
| LjL | well this is just "Ruth", maybe i should tell her that her name is old-fashioned and that makes her statistically more at risk of COVID | 00:55 |
| de-facto | lol | 00:56 |
| LjL | de-facto, i've been made to notice that https://covid19.trackvaccines.org/how-do-vaccines-work/#types also has "replicating viral vector". well, i had noticed it before too, but i just thought "we aren't using these, whatever" | 01:14 |
| LjL | but | 01:14 |
| LjL | wouldn't a replicating viral vector vaccine that both replicates (the adenovirus, or whatever) and encodes the SARS-COV-2 spike protein be a "safe" way to give immunity? | 01:14 |
| LjL | the adenovirus itself would be a mild cold | 01:14 |
| LjL | and it would prime us against the S-protein, without a fully fledged SARS-COV-2 virus risking recombination | 01:15 |
| de-facto | hmm well if it can replicate it has at least the potential to produce a run-away if it cant be guaranteed that immune system would kill it | 01:18 |
| LjL | de-facto, it's an adenovirus, it's already replicating around a lot | 01:19 |
| de-facto | so it would depend on how to answer what can be considered to be safe i guess? | 01:19 |
| LjL | it would only have the difference that it also makes S proteins | 01:19 |
| de-facto | yeah but would the immune system target more that s-protein or the mechanism of the replicating vector | 01:20 |
| LjL | probably both to some extent. i wouldn't necessarily see it as a complete replacement to the vaccines we have... but a vaccine that is "contagious" certainly has advantages, if we somehow can control the dangers | 01:21 |
| de-facto | it would be a fight on two fronts, one real (the replicating vector) and one fake (the s-protein being not a real thread in itself) | 01:21 |
| de-facto | i dont know that though | 01:21 |
| LjL | there are large poorer countries that will only get the "real" vaccines in... who knows how long | 01:22 |
| de-facto | i just would assume the question of safety gets a whole new dimension if the vector is not replication-deficient | 01:22 |
| abmub[m] | It’s clear that the misidentification of exosomes as viruses was a tragic | 01:22 |
| abmub[m] | mistake, one that it’s about time we correct, once and for all. | 01:22 |
| LjL | de-facto, iirc the attenuated polio virus can be contagious | 01:23 |
| de-facto | huh? | 01:23 |
| LjL | polio vaccine* | 01:23 |
| de-facto | yes | 01:23 |
| de-facto | abmub[m], exosomes and viruses are two totally different entities | 01:24 |
| de-facto | dont confuse those | 01:24 |
| de-facto | abmub[m], if you like to learn more about viruses i highly can recommend the lectures by Prof Vincent Racaniello from Columbia University, New York | 01:27 |
| de-facto | .title https://www.youtube.com/watch?v=jX3MhWWi6n4&list=PLGhmZX2NKiNm0vqVhoYB_xZP6E6tGT6rU | 01:27 |
| Brainstorm | de-facto: From www.youtube.com: Virology Lectures 2021 #1: What is a Virus? - YouTube | 01:27 |
| LjL | de-facto, i PM'd you a link | 01:28 |
| Brainstorm | New from Politico: Frustrated EU leaders pass vaccine fight to ambassadors: An internal squabble over extra vaccines was just the latest controversy as the EU tries to speed its inoculation campaign. → https://is.gd/to937u | 02:03 |
| Brainstorm | New from Virology.ws: Trial By Error: Clueless Wall Street Journal Op-Ed Endorses PACE as the “Prevailing View” Among Docs: By David Tuller, DrPH Long Covid stories and commentaries seem to be everywhere—too many to keep track of! This week, The Wall Street Journal published an opinion piece about long Covid and ME/CFS that is breathtakingly [... want %more?] → https://is.gd/6NVuZ1 | 02:14 |
| Brainstorm | New from Virology.ws: T cells will save us from COVID-19: In our quest to stop the COVID-19 pandemic by vaccination, we have been myopically focussed on inducing antibodies against the spike protein. As variants of SARS-CoV-2 have emerged that reduce the ability of such antibodies to block infection, concern has arisen that we will not be able to halt [... want %more?] → https://is.gd/6VMFH9 | 02:35 |
| Brainstorm | New from r/WorldNews: worldnews: Brazil hits record 100,000 coronavirus cases in a day, piling pressure on Bolsonaro → https://is.gd/n5pngH | 02:56 |
| LjL | %tell de-facto these are not numbers that match what i had in my mind, do they seem plausible to you? https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/928729/S0803_CO-CIN_-_Time_from_symptom_onset_until_death.pdf | 03:02 |
| Brainstorm | LjL, I'll pass de-facto your message when they are around. | 03:02 |
| Brainstorm | New from The Atlantic: Listen: A History of Pandemic Xenophobia and Racism: The recent shootings in Atlanta highlighted a surge of anti-Asian violence in the United States throughout the pandemic. Disease stigma and racism have together shaped pandemic response and policy for centuries. → https://is.gd/TPTYPP | 03:48 |
| CoronaBot | /r/coronavirus: Biden will announce new Covid vaccine goal: 200 million shots within his first 100 days (24314 votes) | https://www.cnbc.com/2021/03/25/biden-will-announce-new-covid-vaccine-goal-200-million-shots-within-his-first-100-days.html | https://redd.it/md0o40 | 04:10 |
| CoronaBot | /r/coronavirus: 'I don’t want to be the one who gives it to people': Many Americans won't eat out, fly until COVID-19 herd immunity arrives (34325 votes) | https://www.usatoday.com/story/money/2021/03/24/vaccine-covid-19-travel-fly-eat-restaurant-herd-immunity/6970810002/ | https://redd.it/mck5po | 04:10 |
| CoronaBot | /r/covid19: Another Explanation for Why Cloth Masks Reduce COVID-19 Severity (290 votes) | https://jamanetwork.com/journals/jama/fullarticle/2777695 | https://redd.it/md436k | 04:10 |
| CoronaBot | /r/covid19: mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection (131 votes) | https://science.sciencemag.org/content/early/2021/03/24/science.abg9175 | https://redd.it/md6dj5 | 04:10 |
| CoronaBot | /r/covid19: A novel variant of interest of SARS-CoV-2 with multiple spike mutations detected through travel surveillance in Africa (109 votes) | https://www.krisp.org.za/publications.php?pubid=330 | https://redd.it/md2ol7 | 04:10 |
| CoronaBot | /r/covid19: Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab (136 votes) | https://gut.bmj.com/content/early/2021/03/19/gutjnl-2021-324388 | https://redd.it/mcu1pc | 04:10 |
| CoronaBot | /r/covid19: AZD1222 US Phase III primary analysis confirms safety and efficacy (216 votes) | https://www.astrazeneca.com/media-centre/press-releases/2021/azd1222-us-phase-iii-primary-analysis-confirms-safety-and-efficacy.html | https://redd.it/mcm39d | 04:10 |
| CoronaBot | /r/covid19: Pfizer Initiates Phase 1 Study of Novel Oral Antiviral Therapeutic Agent Against SARS-CoV-2 (347 votes) | https://www.pfizer.com/news/press-release/press-release-detail/pfizer-initiates-phase-1-study-novel-oral-antiviral | https://redd.it/mc3sy1 | 04:10 |
| Brainstorm | New from The Indian Express: World: Missile tests propel N.Korea to top of Biden foreign agenda → https://is.gd/aDJaed | 05:20 |
| Brainstorm | New from r/WorldNews: worldnews: N Korea confirms missile tests as Biden warns of response → https://is.gd/WkXOoM | 06:02 |
| -Synapsestorm- 🌖 Tremblement de terre! Séisme! Earthquake! 5.9 Mwp tremor, registered by 7 agencies, with 4 reports, occurred 23 minutes ago (04:51:38 UTC), with a gibbous moon, Leeward Islands (16.62, -60.8) ± 5 km, ↓22 km likely felt 260 km away (in Basseterre, Charlestown…) by 14700 people (webservices.ingv.it) | 06:15 | |
| Brainstorm | New from The Indian Express: World: Biden sets goal of 200 million COVID-19 vaccine shots in 100 days of his administration → https://is.gd/pDnsTP | 06:44 |
| Brainstorm | New from The Indian Express: World: Brazil hits record 100,000 coronavirus cases in a day, piling pressure on Bolsonaro → https://is.gd/KjftnI | 07:04 |
| Brainstorm | New from The Indian Express: World: EU leaders grapple with surge of infections, vaccine issues → https://is.gd/JhdqHo | 07:25 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Talking About Pandemic in South Carolina on Omegle → https://is.gd/Hd2r56 | 07:56 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 26, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/YB1EUI | 08:06 |
| Brainstorm | New from r/WorldNews: worldnews: Wuhan Institute of Virology 'highly probably' the source of COVID-19 → https://is.gd/EAyowh | 08:58 |
| Brainstorm | New from Medical Xpress: 31 new Washoe County cases of COVID-19 variant; new total 45: Washoe County health officials said Thursday they've identified 31 new cases of the COVID-19 variant that originated in the United Kingdom since they first confirmed more than a dozen in the Reno-Sparks area about two weeks ago. → https://is.gd/p0idOR | 09:08 |
| Brainstorm | New from StatNews: A user’s guide: How to talk to those hesitant about the Covid-19 vaccine: STAT spoke with experts on the frontlines to create this guide on how best to handle difficult conversations about vaccine hesitancy. Their suggestions may surprise you. → https://is.gd/CizaTa | 09:39 |
| -RSSBot[LjLmatrix- Feed: Conferenza stampa del Presidente Draghi ( http://www.governo.it/it/articolo/conferenza-stampa-del-presidente-draghi/16496 ) | 09:47 | |
| Brainstorm | New from StatNews: Opinion: Building back better requires strengthening primary care: Primary care is more vulnerable to external shocks like Covid-19 than most other parts of the U.S. health care system even as it has become more valuable than ever. → https://is.gd/J2xUMR | 09:50 |
| Brainstorm | New from The Indian Express: World: US gives $15 million to Palestinians to deal with COVID-19 → https://is.gd/Vv5O7J | 10:00 |
| Brainstorm | New from The Indian Express: World: Lebanon receives Russian vaccines imported by private sector → https://is.gd/kkf1PV | 11:04 |
| Brainstorm | New from Virological.org: Latest posts: Detection of the B.1.1.7 and B.1.351 SARS-CoV-2 variants in Bangladesh: Epidemiological and phenotypic characterization of certain variants of SARS-CoV-2 have highlighted the changing transmissibility, infectivity and vaccine escape capability of this virus. Of considerable interest are the B.1.351 variant [... want %more?] → https://is.gd/7mibxi | 11:36 |
| Brainstorm | New from The Indian Express (Health): Destination of the week: Thailand to reopen Phuket to vaccinated tourists from July → https://is.gd/P9l9eB | 11:57 |
| Brainstorm | New from EMA: News and press releases: EMA issues advice on use of regdanvimab for treating COVID-19, CHMP, 26/03/2021: EMA’s human medicines committee (CHMP) has completed its review on the use of the monoclonal antibody regdanvimab (also known as CT-P59) to treat... → https://is.gd/R2Nys9 | 12:18 |
| Brainstorm | New from EMA: What's new: General: COVID-19 treatments: Article 5(3) reviews → https://is.gd/rxDg4H | 12:29 |
| Brainstorm | New from The Atlantic: The Pandemic Made My OCD Worse: Brushing my teeth is a struggle. I brush so hard, and for so long, that sometimes my gums bleed. I can’t spit until I’ve touched each tooth carefully with the tip of my tongue. I open and close the medicine cabinet repeatedly, pressing my palm into the pointy corner of the mirror, until it [... want %more?] → https://is.gd/gKg96P | 12:39 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Diners who are fully vaccinated in Illinois won't count against restaurant capacity rules → https://is.gd/qxogEM | 13:00 |
| darsie | Can you get fully vaccinated with AstraZeneca? | 13:25 |
| -RSSBot[LjLmatrix- Feed: M'illumino di meno 2021, Palazzo Chigi aderisce alla giornata per il risparmio energetico ( http://www.governo.it/it/articolo/millumino-di-meno-2021-palazzo-chigi-aderisce-alla-giornata-il-risparmio-energetico/16498 ) | 13:37 | |
| Brainstorm | New from BBC Health: (news): Slight Covid uptick in older school children in England → https://is.gd/5GuEFk | 13:43 |
| Brainstorm | New from Scientific American: Health: People Gave Up on Flu Pandemic Measures a Century Ago When They Tired of Them--and Paid a Price → https://is.gd/S3nnNg | 14:16 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Novavax faces raw-materials shortages for Covid-19 shot; India curbs vaccine exports → https://is.gd/OATJBW | 14:27 |
| de-facto | .tell LjL i guess you remember the clinical reports from Italy in regard to timespan for hospitalization and fatalities https://www.epicentro.iss.it/en/coronavirus/sars-cov-2-analysis-of-deaths | 14:34 |
| Brainstorm | de-facto: At 2021-03-26 02:02:55 UTC, LjL told you: these are not numbers that match what i had in my mind, do they seem plausible to you? https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/928729/S0803_CO-CIN_-_Time_from_symptom_onset_until_death.pdf | 14:34 |
| Brainstorm | de-facto, I'll pass LjL your message when they are around. | 14:34 |
| de-facto | Prof Kekulé is a German physician, epidemiologist, biochemist doing a podcast twice a week about COVID | 14:47 |
| de-facto | at the end they always answer questions via email or phone calls | 14:48 |
| de-facto | .tr <de "Ich bin Lehrerin an einer Schule in Nordrhein-Westfalen und unterrichte einen zehnten Jahrgang. Wir hatten in dieser Woche den ersten Durchgang mit Schnelltests, in dem die halbe Klasse sich testen lassen sollte." | 14:48 |
| Brainstorm | de-facto, German to English: "I am a teacher at a school in North Rhine-Westphalia and teach a tenth grade. This week we had the first round of rapid tests, in which half the class should be tested." (MyMemory, Google) [... want %more?] | 14:48 |
| de-facto | .tr <de "Von 13 Schülerinnen und Schülern haben nur zwei Eltern das Einverständnis zum Schnelltest gegeben. Die anderen elf Schüler haben von den Eltern eine unterschriebene Erklärung mitgebracht, dass sie einer Testung nicht zustimmen." | 14:48 |
| Brainstorm | de-facto, German to English: "Out of 13 students, only two parents gave their consent to the rapid test. The other eleven students brought a signed declaration from their parents that they did not agree to a test." (MyMemory) [... want %more?] | 14:48 |
| de-facto | .tr <de "Diese Schüler kommen aber trotzdem in die Schule. Das Kollegium ist jetzt massiv verunsichert. Wir haben viele Kolleginnen und Kollegen über 60, sogar über 65." | 14:49 |
| Brainstorm | de-facto, German to English: "These students come to school anyway. The staff is now massively insecure. We have many colleagues over 60, even over 65." (MyMemory, Google) — "These students come but nevertheless in the school. The council is massively now unsettled. We have #many colleagues and college's over 60, even over 65th" (Apertium) | 14:49 |
| de-facto | .tr <de "Bei einer Nachbesprechung mit den Eltern kam als Antwort, dass die Familien einer Quarantäne im Falle eines positiven Tests entgehen wollen. Es würde mich sehr interessieren, was Herr Professor Kekulé dazu vorschlägt. Wir sind verzweifelt. Herzlichen Dank, Frau J.“ | 14:49 |
| Brainstorm | de-facto, German to English: "During a debriefing with the parents, the answer was that the families want to avoid quarantine in the event of a positive test. I would be very interested to hear what Professor Kekulé suggests. We are desperate. Thank you very much, Ms. J." (MyMemory) [... want %more?] | 14:49 |
| de-facto | thought it would be relevant to those that assume opening schools can easily be controlled by antigen-quicktests (that are guaranteed to do to harm to the health of participants). | 14:51 |
| de-facto | For those 15% who participate in the free rapid antigen tests, the threat by the remaining 85% refusing to participate by far outweighs their protective contribution. | 14:57 |
| de-facto | I would not be surprised if at working places also many stupid people just deny participating in testing. there are so so many stupid people alive today. | 14:58 |
| de-facto | imho the only solution: strictly enforce participation, while putting harsh fines in place for those that decline participation in antigen-quicktests. it can be absolutely garanteed that there is no physical harm from participating in antigen quicktests. the only reason to decline those is stupidity, selfishness and recklessness. | 15:02 |
| de-facto | btw: each positive antigen-quicktest of course will be verified via PCR. | 15:02 |
| Brainstorm | New from Medical Xpress: Diseases, Conditions, Syndromes: Knowing someone with COVID-19 increased men's anxiety more than women's → https://is.gd/jh6ted | 15:09 |
| Brainstorm | New from Medical Xpress: States race to vaccinate their residents: States are scrambling to vaccinate as many people as they can while the rate of new U.S. coronavirus infections stays steady, but still high, for a third week. → https://is.gd/ZSJmUK | 15:20 |
| CoronaBot | /r/covid19: Should we discount the laboratory origin of COVID-19? (81 votes) | https://link.springer.com/article/10.1007/s10311-021-01211-0 | https://redd.it/mdj4af | 15:32 |
| rpifan | nice | 15:35 |
| de-facto | oh wow exactly what we discussed yesterday night in the CoronaBot article | 15:36 |
| Brainstorm | New from Medical Xpress: EU agency approves AstraZeneca plant caught in UK row: The EU's drug watchdog gave the green light Friday to the Dutch Halix factory to produce AstraZeneca's coronavirus vaccine, which has been at the heart of a bitter dispute with Britain. → https://is.gd/Q3nJd3 | 15:42 |
| Brainstorm | New from Medical Xpress: Officials urge vigilance as Germany sees 3rd infection wave: German health officials warned Friday that the country's latest eruption of coronavirus cases has the potential to be worse than the previous two last year, and they urged people to stay at home during the upcoming Easter break to help slow the rapidly rising numbers [... want %more?] → https://is.gd/v3rg2C | 15:53 |
| de-facto | Assuming IFR[age] = Exp[ Ln[2] age / 5.75} / 186200 any increase of lethality by a factor L would be equivalent to an increase in age of age_increase = Ln[L] 5.75 / Ln[2] e.g. age_increase = Ln(1.64) 5.75 / ln(2) ~ 4.1 years for an increased IFR of 164% (such as for B.1.1.7) | 15:54 |
| de-facto | Hence an infection with B.1.1.7 got the same probability for fatal outcome than an infection with D614G for a patient that is 4.1 years older | 15:55 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: Very nice! More good signs that the immune system can rapidly evolve to recognize SARS2 variants. → https://is.gd/aXfm8O | 16:03 |
| Brainstorm | New from Medical Xpress: Half billion vaccine jabs given: More than 500 million doses of vaccines have been given around the world as of Friday, according to an AFP tally. → https://is.gd/AtmGDy | 16:14 |
| Brainstorm | New from ClinicalTrials.gov: (news): Analysis of Volatile Organic Compounds in Exhaled Air and Sweat: Interest in Rapid Screening for COVID-19 Infection. → https://is.gd/KXyk5b | 16:25 |
| Brainstorm | New from ClinicalTrials.gov: (news): Colchicine and Post-COVID-19 Pulmonary Fibrosis → https://is.gd/Vzh6Fe | 16:36 |
| Brainstorm | New from WebMD: Actor Rita Wilson Reflects on Surviving Cancer, COVID: Actor Rita Wilson expresses gratitude and takes nothing for granted as she reflects on surviving breast cancer and COVID-19. → https://is.gd/9qEwv3 | 16:47 |
| LjL | de-facto, i do remember the ISS reports, although i don't look at them often... partly i guess i don't want to feel too many chills in my spine from the ages going down ;( | 18:01 |
| CoronaBot | /r/coronavirus: When Texas ended its mask mandate, the event cancellations started — and the losses are adding up (10053 votes) | https://www.texastribune.org/2021/03/25/conventions-texas-mask-mandate/ | https://redd.it/mddxa1 | 18:03 |
| LjL | de-facto, but i guess i see what you mean, the time from symptom offset to death is similar to the thing i linked. although the time from hospitalization to death is a lot longer...? i guess i should look at older reports to see if it's always been this way | 18:04 |
| de-facto | also the new B.1.1.7 SARS-CoV-VoC may play a role in this, if it replicates 10-fold and is 164% more lethal it probably also affects median durations of phases in the COVID progression towards fatal outcome | 18:09 |
| de-facto | not so new in UK, but in EU its just becoming the dominant VoC, hence the time of data collection and also average incidence incidence and its distribution (hence load on healthcare system) does play a role in such stats | 18:11 |
| de-facto | i wonder if such data also exists for clinical stats in Brazil (e.g. prior and post P.1 VoC) and South Africe (e.g. prior and post B.1.351 VoC) | 18:14 |
| Brainstorm | New from The Atlantic: COVID-21: A Primer: Trying to remember March 2020 feels like sticking your head into a parallel universe. This time last year, Americans were just going into lockdown—presumably for two weeks—to protect themselves from a mysterious but deadly virus. We disinfected mail but didn’t wear masks. Few of us knew that COVID-19 [... want %more?] → https://is.gd/vrtJIo | 18:34 |
| Brainstorm | New from Scientific American: COVID, Quickly, Episode 3: Vaccine Inequality, plus Your Body the Variant Fighter: Today we bring you the second episode in a new podcast series: COVID, Quickly. Every two weeks, Scientific American’s senior health editors Tanya... -- Read more on ScientificAmerican.com → https://is.gd/cJh2Kc | 18:45 |
| Brainstorm | New from Medical Xpress: Contagious and concerning: What we know about COVID-19 variants: Several coronavirus variants with the potential to be more transmissible have caused global concern over whether existing vaccines will still protect the world from a virus that is constantly mutating. → https://is.gd/XjhwPV | 19:17 |
| Brainstorm | New from Medical Xpress: France steps up travel controls as virus cases soar: The French government announced increased police checks on Friday to enforce travel restrictions in place in Paris and several other regions as coronavirus cases continue to soar around the country. → https://is.gd/bU5vy1 | 19:38 |
| de-facto | .title https://imgur.com/a/kijtivc https://i.imgur.com/cTFeaHh.png "COVID-19 Germany: Reproduction, Cases and Deaths" src: http://metrics.covid19-analysis.org/ | 19:50 |
| Brainstorm | de-facto: From imgur.com: COVID-19 Germany: Reproduction, Cases and Deaths - Album on Imgur | 19:50 |
| de-facto | In my opinion an increasing reproduction number Rt over some period of time is an ALARMING trend. But it seems noone cares until its too late. | 19:54 |
| LjL | de-facto, about the article that says "Should we discount laboratory origin?", it showed up on CoronaBot because it was posted to r/COVID19, but the moderators wrote | 20:09 |
| LjL | "This is being taken down because it's not a "real" paper per se. The authors are either not scientists outright, or not in relevant fields. Most have shown a very biased axe to grind in this matter. It's not published in a relevant journal. | 20:09 |
| LjL | Because of the above, we are removing this submission. Should relevant manuscripts by reputable authors with relevant expertise publish this type of commentary, it would be permissible." | 20:09 |
| Brainstorm | New from Scientific American: Coronavirus News Roundup, March 20 - March 26: Pandemic highlights for the week -- Read more on ScientificAmerican.com → https://is.gd/w4obKD | 20:20 |
| -RSSBot[LjLmatrix- Feed: Concorso 2019, nomina a Consigliere di Stato della vincitrice ( http://www.governo.it/it/articolo/concorso-2019-nomina-consigliere-di-stato-della-vincitrice/16504 ) | 20:27 | |
| Brainstorm | New from NPR: Nearly Half Of States Will Make All Adults COVID-19 Vaccine Eligible By April 15: Officials said Friday that 46 states and Washington, D.C., have announced plans to expand eligibility to all adults by President Biden's May 1 deadline, with many set to do so in the coming weeks. → https://is.gd/N9fX6d | 20:51 |
| CoronaBot | /r/covid19: T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study (80 votes) | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3812375 | https://redd.it/mdo42y | 20:58 |
| Brainstorm | New from Medical Xpress: Cancer drug lessens the toxicity of a protein from COVID-19 virus: University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2—the virus that causes COVID-19—and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects. In their [... want %more?] → https://is.gd/RBZPVA | 21:45 |
| Brainstorm | New from Ars Technica: Science: Experts sound alarm of possible new COVID surge as US cases once again rise → https://is.gd/CjT1FN | 22:06 |
| Brainstorm | Updates for Brazil: +273146 cases (now 12.3 million), +8041 deaths (now 303726) since 3 days ago — United States: +235343 cases (now 30.4 million), +4255 deaths (now 553454) since 3 days ago — India: +160718 cases (now 11.8 million), +861 deaths (now 160972) since 3 days ago — France: +155133 cases (now 4.5 million), +1443 deaths (now 94028) since 3 days ago | 22:18 |
| Brainstorm | New from COVID19 Vaccine Tracker: Shannon McKearnan: Altimmune Inc: AdCOVID → https://is.gd/bnKPpU | 22:38 |
| LjL | de-facto: if I look at the current comments here https://www.reddit.com/r/worldnews/comments/mdymk7/vaccine_row_escalates_as_france_accuses_uk_of/ my sympathy with the UK doesn't increase | 22:42 |
| de-facto | lol so Netherlands is part of UK supply chain, but UK is not part of EU supply chain. Yes that makes sense LMAO | 22:45 |
| de-facto | how many doses did UK supply to EU? | 22:45 |
| de-facto | oh right ZERO. | 22:46 |
| de-facto | how many doses did EU supply to UK? Was it 10M or more? | 22:46 |
| de-facto | What is the reaction for that? oh right accusing the EU of being selfish when trying to hold an UK company accountable to honor their contract. | 22:50 |
| de-facto | how lovely, definitely will make people very happy. | 22:55 |
| de-facto | .title https://www.bbc.com/news/world-europe-56509521 | 22:57 |
| Brainstorm | de-facto: From www.bbc.com: Coronavirus: EU plan for tougher controls on vaccine exports - BBC News | 22:57 |
| de-facto | "Last week, European Commission President Ursula von der Leyen complained that the EU had exported more than 10 million doses to the UK, but the UK had so far exported none in return." | 22:57 |
| de-facto | "Her colleagues added that this had to be seen in the context of the EU being both a global Covid hotspot and also the biggest exporter of vaccines. Since the end of January, EU countries have exported 43 million doses of vaccine to 33 countries not subject to export authorisation, they say." | 22:57 |
| -Synapsestorm- ⭕ 地震? Earthquake? M6+ estimated tremor, possibly occurred 2 minutes ago (22:02:15 UTC), during twilight, Northeast Of Taiwan (26.24, 124.9) ± 4 km, ↓58 km likely felt 310 km away (in 宮古島市, 石垣市…) by 99000 people — Webcams: https://www.windy.com/webcams/1484522198 https://www.windy.com/webcams/1597911339 (www.kmoni.bosai.go.jp) | 23:05 | |
| -Synapsestorm- ⭕ 地震! Earthquake! 6.1 M tremor, registered by yurekuru, occurred 7 minutes ago (22:02:17 UTC), during twilight, Northeast Of Taiwan (26.16, 124.99) ± 9 km, ↓115 km likely felt 290 km away (in 宮古島市, 石垣市…) by 99000 people → https://twitter.com/yurekuru/status/1375568963359281152 — Webcams: https://www.windy.com/webcams/1484522198 (Twitter) | 23:09 | |
| -Synapsestorm- 🌅 地震! Earthquake! 5.9 Mww tremor, registered by EMSC,US,usauto, occurred 16 minutes ago (22:02:15 UTC), during twilight, Northeast Of Taiwan (26.14, 125.07) ± 2 km, ↓80 km likely felt 250 km away (in 宮古島市…) by 51200 people (www.seismicportal.eu) | 23:19 | |
| Brainstorm | New from r/WorldNews: worldnews: Canadian Dr arrested on suspicious activity of killing patience that had covid19 → https://is.gd/GjKqWz | 23:20 |
| LjL | de-facto, people on reddit are asking me now for details, do you have a source with evidence that the EU has been exporting a lot to the UK, but the UK has exported nothing back? | 23:21 |
| de-facto | .title https://ec.europa.eu/commission/presscorner/detail/en/IP_21_1121 | 23:23 |
| Brainstorm | de-facto: From ec.europa.eu: Press corner | European Commission | 23:23 |
| CoronaBot | /r/coronavirus: ‘They don’t care’: US supermarket chain shutters stores after hazard pay rules: Kroger, the largest supermarket chain in the US, lays off employees after local ordinance on hazard pay passed in Los Angeles (10184 votes) | https://www.theguardian.com/us-news/2021/mar/26/krogers-us-supermarket-chain-stores-closed-layoffs | https://redd.it/mdmxwf | 23:23 |
| de-facto | "The EU continues to be the leading provider of vaccines around the world. Six weeks into the existence of this mechanism, 249 export requests to 31 different countries* have been granted for a total of 34,090,267 doses, as they did not threaten the contractual engagements between the EU and the vaccine producers. Only one export request was not granted." | 23:23 |
| de-facto | "The main export destinations include the United Kingdom (with approximately 9.1 million doses), Canada (3.9 million), Mexico (3.1 million), Japan (2.7 million), Saudi Arabia (1.4 million), Hong Kong (1.3 million), Singapore (1 million), United States (1 million), Chile (0.9 million) and Malaysia (0.8 million)." | 23:24 |
| de-facto | afaik UK does not export any vaccines, or did they? | 23:24 |
| de-facto | .title https://twitter.com/vonderleyen/status/1375090365254934531 | 23:25 |
| Brainstorm | de-facto: From twitter.com: error parsing title ('NoneType' object has no attribute 'string') | 23:25 |
| de-facto | "The EU has exported 77 million doses of vaccines to 33 countries since 1 December 2020. In addition, as a lead donor to COVAX, it has contributed to exports to low & middle income countries. While remaining open, the EU needs to ensure Europeans get a fair share of vaccines." | 23:26 |
| de-facto | .title https://www.theguardian.com/world/2021/mar/21/eu-export-ban-would-delay-uk-covid-vaccine-drive-by-two-months | 23:28 |
| Brainstorm | de-facto: From www.theguardian.com: EU export ban would delay UK Covid vaccine drive by two months | World news | The Guardian | 23:28 |
| LjL | de-facto, about the UK not exporting anything, i'm not sure, my dad says they produce a lot of the active substance that we then process further, and that would match some reports that i've read which say that if the EU bans export, the UK threatens to stop exporting "components" (which may be the active substance too? or anyway, other things important to make the vaccine) | 23:29 |
| LjL | i think the reality is probably very complicated with different places producing different things that are all essential | 23:29 |
| de-facto | .title https://www.theguardian.com/world/2021/mar/24/uk-singled-out-for-failing-to-export-covid-vaccines-to-eu | 23:30 |
| Brainstorm | de-facto: From www.theguardian.com: Boris Johnson warns EU not to ban Covid vaccine exports to UK | World news | The Guardian | 23:30 |
| Brainstorm | New from StatNews: Health Tech: Amazon, on the move in health care, is granted authorization for its own Covid-19 test → https://is.gd/rFikre | 23:31 |
| de-facto | afaik the 29M ADZ-1222 doses were produced in Netherlands and UK claims that this is part of their supply chain | 23:31 |
| LjL | "The proposal is mainly aimed at the U.K, which left the EU last year and has imported millions of doses from the bloc but hasn't exported any." https://www.wsj.com/articles/eu-proposes-to-make-it-easier-to-ban-vaccine-exports-11616585780 but semi-paywalled article | 23:32 |
| LjL | de-facto, okay, i've used your links, i've also said i'm not completely sure what's going on with the NL site https://np.reddit.com/r/worldnews/comments/mdymk7/vaccine_row_escalates_as_france_accuses_uk_of/gsck5x4/ | 23:35 |
| de-facto | well i can only speak for myself | 23:40 |
| LjL | de-facto, you mean those 29M doses that were found in Italy? | 23:41 |
| de-facto | about the production in the Netherlands, if it did not receive the EMA approval for doses targeted for EU market, there are two possibilities why 1) EMA was too slow 2) AZ was too slow. Now which of those would be suggested by the interests of each ? | 23:43 |
| LjL | i don't know, i don't think the EMA has shown light speed in things | 23:47 |
| de-facto | huh? | 23:49 |
| de-facto | i dont think the AstraZeneca hast put much effort into production for EU, less than 30% of contract fulfillment hardly is anything that deserves the term "light speed" | 23:50 |
| de-facto | in contrast to the other manufacturers in EU, that delivered their doses according to the contracts hence also did not get into any discussions about exporting | 23:51 |
| de-facto | btw just reading the latest RKI reports | 23:52 |
| de-facto | .title https://imgur.com/a/kshYm00 https://i.imgur.com/7yahtiE.png "COVID-19 Germany: B.1.1.7 SARS-CoV-2-VoC" | 23:52 |
| Brainstorm | de-facto: From imgur.com: COVID-19 Germany: B.1.1.7 SARS-CoV-2-VoC - Album on Imgur | 23:52 |
| de-facto | quite interesting how much variation is in the B.1.1.7 distribution, really looks like growing nests of infection taking over | 23:53 |
| LjL | de-facto, should be "interesting" to look at how the prevalence of B.1.1.7 correlates with mortality in the various locations, but that's not easy because you also have to adjust for the time between cases and deaths | 23:54 |
| de-facto | .title https://imgur.com/a/AalswCI https://i.imgur.com/SOmL5Oj.jpg "COVID-19 Germany: Prognosis of B.1.1.7 out of control" | 23:56 |
| Brainstorm | de-facto: From imgur.com: COVID-19 Germany: Prognosis of B.1.1.7 out of control - Album on Imgur | 23:56 |
| de-facto | lovely. just love.y | 23:56 |
| de-facto | this will be a disaster, exactly as i tell for months now. | 23:57 |
| LjL | :\ | 23:58 |
| de-facto | (picture taken from official RKI report) | 23:58 |
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