| Brainstorm | New from The Lancet (Online): [Viewpoint] US–China health exchange and collaboration following COVID-19: Strong US–China collaboration on health and medicine is a crucial element of the global effort against COVID-19. We review the history of health collaboration and exchanges between the public and private sectors in the USA and China, including [... want %more?] → https://is.gd/1c0Gic | 00:32 |
|---|---|---|
| Brainstorm | New from Ars Technica: Science: B.1.1.7 variant now predominant coronavirus in US; cases spike in Michigan → https://is.gd/1KzKjy | 01:34 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: CDC Says More Virulent British Strain Of Coronavirus Now Dominant In U.S. → https://is.gd/qYn6v0 | 02:25 |
| Brainstorm | Updates for Kharkiv Oblast, Ukraine: +4438 cases (now 111826), +85 deaths (now 2108) since 4 days ago — Odessa Oblast, Ukraine: +4407 cases (now 116407), +104 deaths (now 1985) since 4 days ago — Lviv Oblast, Ukraine: +4176 cases (now 112193), +74 deaths (now 2762) since 4 days ago — Kiev, Ukraine: +3859 cases (now 170517), +156 deaths (now 3701) since 4 days ago | 02:57 |
| Brainstorm | New from BMJ Open: Addressing HIV care, mental health and substance use among youth and young adults in the Bay Area: description of an intervention to improve information, motivation and behavioural skills: Objective Youth represent a population disparately impacted by the HIV epidemic. With most new HIV diagnoses occurring among adolescents and young [... want %more?] → https://is.gd/NwF0YA | 03:17 |
| Brainstorm | New from Virology.ws: A tapeworm drug to treat COVID-19?: Niclosamide (pictured) is a drug that has been approved in humans to treat infections with a variety of tapeworms. It might be useful for preventing SARS-CoV-2 replication and COVID-19 pathogenesis by inhibiting virus-catalyzed membrane fusion. Examination of the lungs of 41 patients who died of [... want %more?] → https://is.gd/X0fjIH | 03:27 |
| Brainstorm | New from r/WorldNews: worldnews: Scientists slam WHO-China report, demand 'full investigation' into COVID-19 origins → https://is.gd/T1q3kD | 03:57 |
| Brainstorm | New from The Indian Express: World: Brazil top court orders probe of Bolsonaro’s pandemic steps → https://is.gd/Ncbsv3 | 04:58 |
| Brainstorm | New from r/WorldNews: worldnews: Covid infections in Canada edge closer to US rate → https://is.gd/FM7cy1 | 06:31 |
| Brainstorm | New from r/WorldNews: worldnews: People under 50 turned away from Melbourne vaccination centre after new AstraZeneca advice - ABC News → https://is.gd/a2oDMN | 06:41 |
| Brainstorm | New from The Indian Express: World: Japan to add Tokyo, other areas to COVID-19 ‘quasi-emergency’ state → https://is.gd/WRdPnu | 06:51 |
| Brainstorm | New from r/WorldNews: worldnews: GOP House leader McCarthy says vaccine passports more fitting for ‘Communist China’ → https://is.gd/Z1Ftn1 | 07:02 |
| Brainstorm | New from The Indian Express: World: World’s wealthiest countries are getting vaccinated 25 times faster → https://is.gd/JNy5Vj | 08:34 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | April 09, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/PB3pHh | 09:06 |
| Brainstorm | New from EMA: What's new: Orphan: Orphan designation: Radio-iodinated (131I) anti-CD45 murine monoclonal antibody, Treatment in haematopoietic stem cell transplantation, 14/10/2016, Positive → https://is.gd/lBaaAb | 09:16 |
| Haley[m] | %cases France | 09:29 |
| Brainstorm | Haley[m]: In France, there have been 4.9 million confirmed cases (7.3% of the population) and 97364 deaths (2.0% of cases) as of a day ago. 67.8 million tests were performed (7.2% positive). See https://offloop.net/covid19/?default=France for time series data. | 09:29 |
| Brainstorm | New from Medical Xpress: Sunlight linked with lower COVID-19 deaths, study shows: Sunnier areas are associated with fewer deaths from Covid-19, an observational study suggests. → https://is.gd/pVfFhE | 10:16 |
| Brainstorm | New from The Indian Express: World: China repeats call to resist ‘vaccine nationalism’, pledges to keep monetary support → https://is.gd/MUTw1v | 10:22 |
| Brainstorm | New from StatNews: Scientists work toward an elusive dream: a simple pill to treat Covid-19: The world has vaccines that can prevent most cases of Covid-19. It even has drugs that can help with the most serious symptoms. Now what it needs is a Tamiflu… → https://is.gd/oxPWaB | 10:44 |
| Brainstorm | New from Medical Xpress: Tokyo tightening virus measures nearly 100 days before Olympics: Japan's government will approve tighter coronavirus measures for the capital on Friday, weeks after lifting a state of emergency and with just over 100 days until the postponed Tokyo Olympics. → https://is.gd/BeuQV6 | 11:18 |
| Brainstorm | New from BMJ: What do we know about China’s covid-19 vaccines?: What vaccines has China developed?There are about a dozen Chinese vaccine candidates for covid-19, but five front runners have received emergency use approval in China as well as several other... → https://is.gd/z3B09R | 11:39 |
| bingbotboom | is this WHO affiliate? | 11:42 |
| greyman | calbasi_matrix:cointop | 11:51 |
| Brainstorm | New from Medical Xpress: India's hardest-hit state battles huge vaccine shortages: Leading hospitals in India's most coronavirus-hit state halted vaccinations Friday, citing shortages as infections across the country crossed 13 million and set a new daily record. → https://is.gd/2f0Y6F | 12:11 |
| Brainstorm | New from StatNews: Biotech: STAT+: Natural killer cells, primed with an antibody, induce remissions in patients with advanced blood cancer → https://is.gd/Nb4Fhh | 12:44 |
| Brainstorm | New from BMJ: How the JCVI sets who gets a covid-19 vaccine and when: What is the JCVI?The 16 experts who make up the independent Joint Committee on Vaccination and Immunisation (JCVI) advise UK health departments, help develop immunisation programmes, and identify... → https://is.gd/2HXFOS | 13:39 |
| Brainstorm | New from Derek Lowe: @JasonUkman: RT by @Dereklowe: Scientists work toward an elusive dream: a simple pill to treat Covid-19. → https://is.gd/vOed5C | 13:50 |
| Atque | Any know about astra zeneca vaccine risks with blood clots? | 13:59 |
| Atque | Opinions on it? | 13:59 |
| eventcheck[m] | Isn't coronavirus itself known to give blood clots? | 14:13 |
| Brainstorm | New from Politico: Coronavirus: Norwegian prime minister fined over lockdown-breaking birthday bash → https://is.gd/5dKE8Z | 14:23 |
| finely[m] | <Atque "Any know about astra zeneca vacc"> Check some of my recent posts. | 14:41 |
| finely[m] | <eventcheck[m] "Isn't coronavirus itself known t"> Yes | 14:42 |
| kreyren | https://www.youtube.com/watch?v=huvdOBk7-Jc | 14:48 |
| kreyren | > Vaccine rollout in EU 'unacceptably slow' says WHO | COVID Update | 14:48 |
| Brainstorm | New from r/WorldNews: worldnews: Japanese doctors perform world's first living donor lung transplant to a Covid-19 patient → https://is.gd/9FjVoc | 15:30 |
| Brainstorm | New from Medical Xpress: Antipsychotic drugs may have protective effect against COVID-19: Two studies led by the Mental Health Unit of the Virgen del Rocio University Hospital and involving researchers from the US conclude that antipsychotic drugs could have a protective effect against SARS-CoV-2. For this reason, patients treated with these drugs have [... want %more?] → https://is.gd/IXElBx | 15:41 |
| Brainstorm | New from Medical Xpress: Balancing benefits and risks: Making sense of the latest vaccine news: Last night, the federal government announced substantially revised plans for the use of the AstraZeneca vaccine in Australia. → https://is.gd/4wBfmC | 15:52 |
| Brainstorm | New from Medical Xpress: No region in the world spared as virus cases, deaths surge: Hospitals in Turkey and Poland are filling up fast. Pakistan is restricting domestic travel to bring a surge in coronavirus infections under control. Even Thailand, which has weathered the coronavirus pandemic far better than many nations, is now struggling to contain [... want %more?] → https://is.gd/i4q4HG | 16:15 |
| -RSSBot[LjLmatrix- Feed: Il Presidente Draghi incontra il Commissario Ue Gentiloni ( http://www.governo.it/it/articolo/il-presidente-draghi-incontra-il-commissario-ue-gentiloni/16584 ) | 16:19 | |
| de-facto | .title https://news.utexas.edu/2021/04/05/human-trials-begin-for-a-low-cost-covid-19-vaccine-to-extend-global-access/ | 16:23 |
| Brainstorm | de-facto: From news.utexas.edu: Human Trials Begin for a Low-Cost COVID-19 Vaccine to Extend Global Access - UT News | 16:23 |
| de-facto | .title https://en.wikipedia.org/wiki/NDV-HXP-S | 16:23 |
| Brainstorm | de-facto: From en.wikipedia.org: NDV-HXP-S - Wikipedia | 16:23 |
| de-facto | .title https://science.sciencemag.org/content/369/6510/1501 | 16:26 |
| Brainstorm | de-facto: From science.sciencemag.org: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science | 16:26 |
| -RSSBot[LjLmatrix- Feed: Concorso, a 40 posti di Referendario di T.A.R. anno 2021: ampliamento dei posti e proroga della scadenza ( http://www.governo.it/it/articolo/concorso-40-posti-di-referendario-di-tar-anno-2021-ampliamento-dei-posti-e-proroga-della ) | 16:29 | |
| de-facto | "The most promising variant, Combo47, renamed HexaPro, contains all four beneficial proline substitutions (F817P, A892P, A899P, A942P) as well as the two proline substitutions in S-2P." | 16:34 |
| de-facto | the two proline subs in S-2P are K986P, V987P, hence HexaPro is Wuhan spike-glycoprotein with (F817P, A892P, A899P, A942P and K986P, V987P) | 16:34 |
| Brainstorm | New from Medical Xpress: Inside Covid vaccine production at BioNTech's new plant: Decontamination chambers, tight-fitting protective suits, a controlled atmosphere: vigilance is the order of the day when making COVID-19 vaccines at the new BioNTech plant in Marburg, Germany. → https://is.gd/hpPMPi | 16:38 |
| Brainstorm | New from Medical Xpress: At a French warehouse, the logistics of racing out vaccines: In an unmarked warehouse on the outskirts of Paris, a precious cargo emerges from the icy cold mist: nearly 10,000 doses of the Pfizer-BioNTech vaccine have just been delivered. → https://is.gd/rMvDaW | 16:49 |
| de-facto | .title https://www.ema.europa.eu/en/news/meeting-highlights-pharmacovigilance-risk-assessment-committee-prac-6-9-april-2021 | 16:55 |
| Brainstorm | de-facto: From www.ema.europa.eu: Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 6-9 April 2021 | European Medicines Agency | 16:55 |
| rmonten[m] | I was just about to post the same link. | 16:56 |
| rmonten[m] | 4 cases of blood clotting events with Janssen, but it doesn't say how many doses have been administered. | 16:57 |
| de-facto | "PRAC has started a review of a safety signal to assess reports of thromboembolic events (formation of blood clots, resulting in the obstruction of a vessel) in people who received COVID-19 Vaccine Janssen." | 16:57 |
| de-facto | oh dear. | 16:57 |
| de-facto | yeah it does not say out of how many indeed | 16:57 |
| de-facto | and that is the important point, how does the vaccination group compare to the expectation value from background control group of non-vaccinated individuals | 16:58 |
| rmonten[m] | still, it's likely the adenovirus vector? | 16:58 |
| rmonten[m] | which they both use | 16:58 |
| de-facto | i dont know, both are adenovirus vectors, yeah | 16:58 |
| de-facto | AstraZeneca uses ChAdOx1 and Jannsen AD.26 afaik | 16:59 |
| bin_bash | yeah that would be my thought too but more study is needed to be sure | 16:59 |
| de-facto | so different ones | 16:59 |
| rmonten[m] | there's this cryptic comment “unusual blood clots with low blood platelets” that seems to suggest that the symptoms are similar | 17:00 |
| rmonten[m] | right | 17:00 |
| Brainstorm | New from The Indian Express: World: As many countries pause AstraZeneca vaccine, others prescribe age limits for administering shot → https://is.gd/yECRAM | 17:00 |
| rmonten[m] | I remember Derek Lowe mentioned the adenovirus binding to platelets as a potential explanation. Looking back, he got that from this paper: | 17:05 |
| rmonten[m] | .title https://www.researchsquare.com/article/rs-362354/v1 | 17:05 |
| Brainstorm | rmonten[m]: From www.researchsquare.com: A Prothrombotic Thrombocytopenic Disorder Resembling Heparin-Induced Thrombocytopenia Following Coronavirus-19 Vaccination | Research Square | 17:05 |
| Brainstorm | New from ClinicalTrials.gov: (news): the Impact of Covid-19 Pandemic Stress on Pregnancy Outcomes → https://is.gd/8pqPnO | 17:11 |
| Brainstorm | New from ClinicalTrials.gov: (news): Monitoring Serologic Response to Severe Acute Respiratory Syndrome-2 (SARS-COV-2)/COVID-19 in Children → https://is.gd/AonFzH | 17:23 |
| Brainstorm | New from ClinicalTrials.gov: (news): Institutional Registry on Outpatient and Hospitalized COVID-infected Patients → https://is.gd/tbZkPY | 17:33 |
| Brainstorm | New from ClinicalTrials.gov: (news): Study of Intravenous Ampion in Adult COVID-19 Patients Requiring Supplemental Oxygen → https://is.gd/nsvql2 | 17:45 |
| de-facto | rmonten[m], yes also https://gth-online.org/wp-content/uploads/2021/03/GTH-Statement-AstraZeneca_englisch_3-29-2021.pdf | 17:48 |
| de-facto | not sure if its the same issue though, afaik the real cause itself is not understood | 17:48 |
| de-facto | the issue with the antibodies and the effect (the resulting problems) seem to be somewhat understood i guess, they provide a testing scheme | 17:49 |
| de-facto | i wonder if they do screening in AstraZeneca vaccinated people without problems for such antibody reaction | 17:49 |
| de-facto | if they include much more into their statistics they might be able to estimate an age specific risk for such rate but tragic progressions | 17:50 |
| LjL | Great news about Janssen :/ | 17:52 |
| de-facto | yet we dont know out of how many and if its similar to AstraZeneca at all, only that they investigate | 17:53 |
| LjL | de-facto: and also... a *separate* safety signal about AZ? | 17:55 |
| LjL | and more than 700 deaths today in Italy. Despite that, a few regions are reopening to one level down | 17:56 |
| LjL | (Including mine) | 17:56 |
| Brainstorm | New from ClinicalTrials.gov: (news): Efficacy and Safety of Three Different Doses of an Anti SARS-CoV-2 Hyperimmune Equine Serum in COVID-19 Patients → https://is.gd/jZ2AJs | 17:56 |
| de-facto | LjL, i am not sure if its separate, i understand it as two sides of the same coin, thrombocytopenia and the leaky blood vessels as well as the CVST | 17:58 |
| de-facto | about the AZ only i mean | 17:58 |
| de-facto | the Janssen is separate from that (since its another vaccine) | 18:00 |
| de-facto | both indeed employ Adenoviruses | 18:00 |
| LjL | de-facto: it says only 5 cases... Kinda sounds like a separate concern to me | 18:01 |
| -RSSBot[LjLmatrix- Feed: Il Presidente Draghi incontra il segretario del Pd Enrico Letta ( http://www.governo.it/it/articolo/il-presidente-draghi-incontra-il-segretario-del-pd-enrico-letta/16586 ) | 18:04 | |
| LjL | de-facto: the agenda PDF they have at the bottom of the page makes me guess the events, or some of them at least, occurred in Belgium (page 11) | 18:07 |
| Brainstorm | New from Scientific American: COVID, Quickly, Episode 4: The Virtual Vaccine Line and Shots for Kids: Today we bring you the fourth episode in a new podcast series: COVID, Quickly. Every two weeks, Scientific American’s senior health editors Tanya... -- Read more on ScientificAmerican.com → https://is.gd/bJgx8P | 18:07 |
| LjL | de-facto: meanwhile, some guidance on how to treat the AZ issue from Britain https://b-s-h.org.uk/about-us/news/guidance-produced-from-the-expert-haematology-panel-ehp-focussed-on-syndrome-of-thrombosis-and-thrombocytopenia-occurring-after-coronavirus-vaccination and https://b-s-h.org.uk/media/19530/guidance-version-13-on-mngmt-of-thrombosis-with-thrombocytopenia-occurring-after-c-19-vaccine_20210407.pdf from ##science | 18:08 |
| de-facto | yeah pretty much the same as we already know | 18:15 |
| Brainstorm | New from Medical Xpress: New EU vaccine probe deepens Europe's COVID woes: Europe's stuttering vaccine rollout faced multiple shocks on Friday as EU regulators said they were reviewing side effects of the Johnson & Johnson shot and France further limited its use of the AstraZeneca jab. → https://is.gd/7gL3Z6 | 18:18 |
| de-facto | LjL, maybe you should add those links to the two you already have | 18:22 |
| de-facto | .links thrombocyto | 18:24 |
| Brainstorm | de-facto, https://www.researchsquare.com/article/rs-362354/v1 (A Prothrombotic Thrombocytopenic Disorder Resembling Heparin-Induced Thrombocytopenia Following Coronavirus-19 Vaccination) is a preprint study released by the German Society for Thrombosis and Hemostasis Research (GTH) after a [... want %more?] | 18:24 |
| LjL | de-facto: I meant to add the EMA safety report. It's just I'm on phone right now. You mean the UK links? | 18:24 |
| de-facto | yup the uk links | 18:24 |
| Brainstorm | New from BBC Health: Coronavirus infections 'a sixth of January peak': ONS estimates that one-in-350 people in the UK currently have coronavirus → https://is.gd/4Jep5l | 18:39 |
| de-facto | so we have the sequence of the Janssen vaccine? | 18:40 |
| de-facto | also what about Sputnik V? afaik the primer (or was it the booster) also uses Ad26 | 18:42 |
| de-facto | .title https://www.nature.com/articles/s41541-020-00243-x | 18:43 |
| Brainstorm | de-facto: From www.nature.com: Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses | npj Vaccines | 18:43 |
| Brainstorm | New from Medical Xpress: COVID-19 vaccines bring optimism amid concerns about a fourth wave of infections: More than 60 million Americans have been fully vaccinated against COVID-19, according to the Centers for Disease Control and Prevention (CDC). The large scale vaccination efforts underway across the U.S. to vaccinate those eligible come at a time [... want %more?] → https://is.gd/GQEb1S | 18:50 |
| de-facto | hmm does the final product contian tPA or not? | 18:54 |
| rmonten[m] | de-facto: good question, is there a similar monitoring system in any country where Sputnik V is used? | 18:54 |
| de-facto | not sure about htat | 19:00 |
| de-facto | things might be a little bit different in Russia? actually i dont know enough about their surveillance | 19:01 |
| LjL | It's used in more countries than just Russia though... Including the EU (well, one entire country in the EU) | 19:16 |
| rpifan | you mean sputnik V | 19:20 |
| rpifan | bavaria is trying to buy 2 million doses | 19:20 |
| Brainstorm | New from BMJ: Covid-19 vaccines save lives: At the time of writing, over 500 million doses of vaccines to combat SARS-CoV-2 have been delivered worldwide. Not every country has received an equal share, however. The differences in rollout have... → https://is.gd/M5xS9o | 19:32 |
| rpifan | 500 million out of 7.6 billion | 19:36 |
| finely[m] | https://pluralistic.net/2021/04/08/howard-dino/#the-scream | 19:38 |
| finely[m] | More on Howard Dean's betrayal of humanity: quote | 19:38 |
| finely[m] | "The racist lie that brown people can't manufacture their own vaccines is being peddled to maximize profits for some of the cruellest, most profitable, most publicly subsidized companies on Earth – and it's not merely unfair, it's an existential threat to human civilization." | 19:38 |
| finely[m] | <de-facto "i wonder if they do screening in"> I heard a German group is working on a test for the antibody reaction. I couldn't find a good source for it though. | 19:40 |
| Brainstorm | New from Politico: Italy fears mob has infiltrated vaccination campaign: Deaths from coronavirus are rising as vaccines fail to reach elderly and vulnerable. → https://is.gd/Hc9ZDz | 19:42 |
| finely[m] | <rmonten[m] "there's this cryptic comment “un"> The platelet abnormalities are associated with the condition. White blood cells too. | 19:43 |
| LjL | as if there's anything it hasn't infiltrated | 19:43 |
| rmonten[m] | (obvious yo momma joke implied) | 19:57 |
| Brainstorm | New from Politico: Hungary to assess Sputnik V vaccine for Slovakia use: It’s the latest twist in a row involving Slovakia's ex-prime minister, its drugs regulator and Russia over Sputnik V. → https://is.gd/J4oIlz | 20:03 |
| Brainstorm | New from Derek Lowe: @Dereklowe: Slovakian regulators say that the Sputnik vaccine they have received from Russia appears to have been produced in multiple (rather different) lots, with dosage formsand packaging, and via different processes. They're not [... want %more?] → https://is.gd/aVu1Tm | 20:35 |
| Blankspace | Hi | 20:45 |
| Brainstorm | New from FDA Press Releases: Coronavirus (COVID-19) Update: April 9, 2021: The FDA recommends health care personnel and facilities transition from the use of decontaminated disposable respirators, and issues warning letters to two companies for selling unapproved products with fraudulent COVID-19 claims. → https://is.gd/egkilG | 20:45 |
| LjL | hi Blankspace | 20:48 |
| Blankspace | Covid is getting bad in India | 20:49 |
| LjL | yeah :( probably because of variants including E484K | 20:49 |
| Blankspace | I know someone who died | 20:50 |
| Blankspace | Because of covid | 20:50 |
| LjL | i'm sorry | 20:50 |
| LjL | the current curve for India does look really, really bad | 20:50 |
| LjL | perhaps the worst-looking spike i've seen for any country (that i've looked at) | 20:50 |
| de-facto | Blankspace, do you know how the portion of positive tests develops in India? | 20:51 |
| LjL | %links india | 20:51 |
| Brainstorm | LjL, https://indianexpress.com/article/cities/delhi/coronavirus-noida-aarogya-setu-app-police-6395945/ (India is forcing people to use its covid app, unlike any other democracy), according to Technology Review, although it does on to qualify it's not just compulsory across the country; [... want %more?] | 20:51 |
| LjL | %links india tracker | 20:51 |
| Brainstorm | LjL, https://outbreak.info/ (outbreak.info) is not primarily a case tracker, but it does offer various case visualizations including for some sub-national regions (United States, Brazil, India...) | 20:51 |
| LjL | pfft | 20:51 |
| LjL | (i wanted https://www.covid19india.org/) | 20:51 |
| Blankspace | What do you mean De facto | 20:51 |
| Blankspace | I did not understand | 20:52 |
| LjL | Blankspace, he wants to know how many tests are done, in comparison to the people who are found positive. so the ratio between positives and tested | 20:52 |
| LjL | de-facto, https://www.covid19india.org/ has the amount of tests | 20:52 |
| LjL | also vaccines | 20:52 |
| de-facto | for every 100 tests that have been done in India, how many have a positive result? | 20:52 |
| LjL | from 16.3% in Maharashtra, down to 0.2 in Arunchal Pradesh. overall in India, 7.9% | 20:53 |
| de-facto | oh damn, the number of tests did not really increase (maybe a little bit only), yet the number of positive cases raise exponentially | 20:54 |
| LjL | at least i think that's what those numbers are | 20:54 |
| LjL | actually maybe not, ignore me | 20:54 |
| de-facto | yeah i mean over time | 20:54 |
| LjL | they should have an option to switch to English-without-lakh-and-crore :P | 20:55 |
| de-facto | indeed | 20:55 |
| Blankspace | 10 lakh is 1 million | 20:56 |
| de-facto | Blankspace, do you have an idea why there is such a big increase in new infections? | 20:56 |
| Blankspace | I think people took it lightly didn't follow the protocol but nobody knows why it is spreading this rapidly | 20:57 |
| Blankspace | It's really scary we've very high population density | 20:57 |
| Blankspace | It could be varied reasons | 20:57 |
| Blankspace | And there are mutants also | 20:58 |
| de-facto | from the spike something changed (relative to prior increase), maybe mutants, maybe something in behavior, maybe something else? | 20:59 |
| LjL | New Zealand has halted all travel from India, including New Zealand citizens. When New Zealand does COVID things, they usually know what they're doing... | 20:59 |
| LjL | (and you know, New Zealand has strict quarantines for incoming travelers anyway, but in this case they just halted it) | 20:59 |
| de-facto | http://metrics.covid19-analysis.org/ | 20:59 |
| de-facto | .title | 20:59 |
| Brainstorm | de-facto: From metrics.covid19-analysis.org: Visualizing COVID-19 Spread Metrics | 20:59 |
| Blankspace | I am sure they'll do some arrangement for their own citizen | 21:00 |
| LjL | well, it's a temporary ban | 21:00 |
| LjL | but i'm just saying if NZ is taking the India situation seriously, then it's probably serious | 21:01 |
| de-facto | .title https://imgur.com/a/iqQwojD https://i.imgur.com/p79npc2.png src: http://metrics.covid19-analysis.org/ | 21:01 |
| Brainstorm | de-facto: From imgur.com: COVID-19 India: Cases and Reproduction number Rt - Album on Imgur | 21:01 |
| Blankspace | It's serious | 21:01 |
| LjL | India is a big vaccine producer though. they should vaccinate as quickly as possible | 21:01 |
| Blankspace | Seriously bad | 21:01 |
| Blankspace | We've shortage of vaccines | 21:02 |
| de-facto | India having a reproduction of Rt = 1.37 that is serious indeed | 21:02 |
| de-facto | meaning daily new infections double each t2 = ts Ln(2) / Ln(Rt) = 5.2d Ln(2) / Ln(1.37) = 5.2d 2.2 ~ 11.5 days | 21:04 |
| Blankspace | Have they got no solution in past 2 yrs | 21:05 |
| de-facto | it means for each 10 currently infected people there are 13.7 new infections each 5.2 days | 21:06 |
| Brainstorm | New from Scientific American: Coronavirus News Roundup, April 3 – April 9: Pandemic highlights for the week -- Read more on ScientificAmerican.com → https://is.gd/oGtPcB | 21:06 |
| de-facto | .title https://pib.gov.in/PressReleaseIframePage.aspx?PRID=1707177 | 21:09 |
| Brainstorm | de-facto: From pib.gov.in: document without title | 21:09 |
| de-facto | "Genome Sequencing by INSACOG shows variants of concern and a Novel variant in India" | 21:10 |
| de-facto | .title https://timesofindia.indiatimes.com/city/mumbai/maharashtra-double-mutation-variant-not-linked-to-surge-yet/articleshow/81677389.cms | 21:10 |
| Brainstorm | de-facto: From timesofindia.indiatimes.com: Maharashtra: Double mutation variant not linked to surge yet | Mumbai News - Times of India | 21:10 |
| LjL | "not linked yet" seems like what agencies like the EMA like to say | 21:10 |
| de-facto | we already talked about that few days ago here | 21:11 |
| de-facto | (hence my repetition of the links from scrollback buffer) | 21:11 |
| de-facto | possibly related? not sure | 21:12 |
| de-facto | .title https://www.biorxiv.org/content/10.1101/2021.03.18.436013v1 | 21:13 |
| Brainstorm | de-facto: From www.biorxiv.org: The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice | bioRxiv | 21:13 |
| de-facto | afaik the double mutant in India also contains E484K | 21:13 |
| rpifan | nice | 21:13 |
| rpifan | double mutant | 21:13 |
| de-facto | yeah its what they call it, nothing new or scary | 21:15 |
| de-facto | they just mean mutant (as all other VoCs) with two mutations E484Q and L452R | 21:16 |
| de-facto | in above paper they say "Here we show that unlike the initial virus, VOCs are able to infect common laboratory mice, replicating to high titers in the lung" | 21:17 |
| de-facto | "The E484K mutation found in the RBD of variants B.1.351 and P.1 is also located in the ACE2 binding interface, resulting in a more positively charged RBD surface, in turn contributing to better binding to the negatively charged patch in mACE2, and might explain the differences observed in vivo." | 21:18 |
| de-facto | "This interpretation is consistent with recent results obtained with pseudotyped viruses showing that the N501Y, E484K and their combination increase entry in mACE2 expressing cells." | 21:18 |
| de-facto | B.1.351 is the South African SARS-VoV-2-VoC, P.1 is the Brazilian VoC | 21:19 |
| Blankspace__ | So we we going to die in this pandemic | 21:19 |
| de-facto | both contain E484k | 21:19 |
| de-facto | Blankspace__, no not at all | 21:19 |
| de-facto | its problematic but its not that lethal | 21:20 |
| Blankspace__ | We don't know | 21:21 |
| de-facto | there are studies, they look for antibodies in the blood of people, and if the blood contains antibodies it means those people had contact with the virus. some of them did not even notice (so called asymptomatic cases) | 21:21 |
| de-facto | by such seroprevalence studies they can find out for each 100 people how many had contact with the virus | 21:22 |
| de-facto | if they do that for each age group they can give a probability for exposure as function of age | 21:22 |
| de-facto | that is the attack rate, or infection rate | 21:23 |
| de-facto | now for each such age group they also know how many people did have a severe progression that leads to death | 21:23 |
| de-facto | so they know the death rate per infection rate | 21:23 |
| de-facto | that is called the infection fatality rate (IFR) | 21:24 |
| de-facto | the IFR gives the probability for an infected individual to have a lethal outcome | 21:24 |
| de-facto | .title https://link.springer.com/article/10.1007%2Fs10654-020-00698-1 | 21:25 |
| Brainstorm | de-facto: From link.springer.com: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications | SpringerLink | 21:25 |
| de-facto | Their Log10(IFR) = -3.27 + 0.0524 * age is the same as IFR[age] = Exp[Ln[2] age / 5.74485 ] / 1862.09 in percent or ifr[age] = Exp[Ln[2] age / 5.75 ] / 186209 normalized to 1 doubling with each increase of age by 5.75 years, ifr[85.72] = 1/6 or ifr[72=2021-1949] = 1/31.41 | 21:26 |
| Brainstorm | New from r/WorldNews: worldnews: Pandemic, hunger force thousands into sex work in Mexico → https://is.gd/KgBe7O | 21:27 |
| de-facto | .title https://imgur.com/a/Vh4eukV https://i.imgur.com/uqSkTG7.png | 21:28 |
| de-facto | that is for the B.1 variant before all the SARS-CoV-2-VoCs occurred, its the D614G mutation | 21:29 |
| de-facto | the VoCs might have a higher fatality rate, but not by much, e.g. B.1.1.7 (the UK VoC) has something like 164% IFR of B.1 | 21:30 |
| de-facto | so we are NOT all going to die in this pandemic, it is serious but not the lethality of SARS-CoV-2 is quite low in the young and healthy, it rises exponentially with age though, doubling each 5.75 years | 21:33 |
| de-facto | and vaccinations seem to be able to prevent severe progressions as well as fatal outcomes quite efficiently | 21:33 |
| Blankspace__ | I am going to sleep | 21:34 |
| de-facto | for example in Germany now the age of people in the hospital goes down because the elderly were vaccinated first, hence are much much less likely to have severe progressions | 21:34 |
| de-facto | so vaccination really will help a lot | 21:34 |
| Blankspace__ | Shortage is there | 21:35 |
| de-facto | yes thats true | 21:35 |
| de-facto | we really need much more production capacity for vaccinations | 21:35 |
| de-facto | fortunately India got one of the biggest production facilities with the State Serum Institute | 21:35 |
| de-facto | and afaik they postponed export of vaccinations till summer, so i guess they are working hard on ramping up vaccinations for Indian people | 21:36 |
| Brainstorm | New from Medical Xpress: Scientists find clues to why AstraZeneca's vaccine may cause clots: (HealthDay)—Doctors might have figured out why AstraZeneca's COVID-19 vaccine may cause life-threatening blood clots in very rare cases. → https://is.gd/BJYVl8 | 21:37 |
| de-facto | yet breaking the current peak immediate non-pharmaceutical-interventions (NPIs) are requires, reducing contact rates between people and thereby lowering the probability for virus transmission | 21:37 |
| de-facto | the reproduction is R = Transmissibility * ContactRate * DurationOfInfectiousness | 21:38 |
| de-facto | so if currently R ~ 1.37 it means the increase in daily new infections could become constant (hence R~1) for a reduced contact rate of 1/1.37 = 0.72 | 21:39 |
| de-facto | if a reduction of cases is the goal (e.g. R~0.7) it would mean contact rate would have to decrease to 1.37/0.7 ~0.51, so for each two contacts right now there only should be allowed to be 1 contact in such a decreasing scenario | 21:41 |
| de-facto | i really do hope India is going to get this under control soon | 21:53 |
| Brainstorm | New from r/WorldNews: worldnews: Brazil Top Court Orders Probe Of Bolsonaro's Pandemic Steps → https://is.gd/MRgF62 | 22:08 |
| Brainstorm | New from COVID19 Vaccine Tracker: Shannon McKearnan: Altimmune Inc: AdCOVID → https://is.gd/bnKPpU | 23:09 |
| -RSSBot[LjLmatrix- Feed: Campagna vaccinale, firmata l'Ordinanza n. 6/2021 del Commissario per l'emergenza Covid-19 ( http://www.governo.it/it/articolo/campagna-vaccinale-firmata-lordinanza-n-62021-del-commissario-lemergenza-covid-19/16588 ) | 23:34 | |
| Brainstorm | New from r/WorldNews: worldnews: Ontario records more than 4,200 new COVID-19 cases, highest daily count ever → https://is.gd/XiJq8e | 23:40 |
| Brainstorm | New from r/WorldNews: worldnews: McDonald's will close hundreds of locations in Walmart stores as pandemic changes shopping habits → https://is.gd/TMSe65 | 23:50 |
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