| LjL | with a very... VERY... suspiciously "flashy" site for that https://c19hcq.com/ | 00:00 |
|---|---|---|
| Brainstorm | New from Ars Technica: Science: 99.992% of fully vaccinated people have dodged COVID, CDC data shows → https://is.gd/UOv1pM | 00:11 |
| de-facto | hmmm | 00:11 |
| de-facto | i have seen that url in the Campbell video above | 00:15 |
| de-facto | indeed i agree with you LjL it looks a bit biased | 00:17 |
| Brainstorm | New from r/WorldNews: worldnews: India reports a record of more than 200,000 new COVID-19 cases in a single day → https://is.gd/5uQe14 | 00:31 |
| Brainstorm | New from The Lancet (Online): [Comment] Ten scientific reasons in support of airborne transmission of SARS-CoV-2: Heneghan and colleagues' systematic review, funded by WHO, published in March, 2021, as a preprint, states: “The lack of recoverable viral culture samples of SARS-CoV-2 prevents firm conclusions to be drawn about airborne [... want %more?] → https://is.gd/z48qqZ | 00:42 |
| LjL | %title https://www.reuters.com/world/americas/brazils-covid-19-response-cost-thousands-lives-says-humanitarian-group-2021-04-15/ ugh | 00:59 |
| Brainstorm | LjL: From www.reuters.com: Brazil's hospitals running out of sedatives as COVID-19 rages | Reuters | 00:59 |
| de-facto | 3k fatal outcomes daily in Brazil | 01:03 |
| de-facto | https://www.worldometers.info/coronavirus/country/brazil/ | 01:03 |
| LjL | still not even as bad as what India looks like it'll soon be | 01:04 |
| de-facto | yeah daamn https://www.worldometers.info/coronavirus/country/india/ | 01:04 |
| de-facto | it looks really bad | 01:04 |
| LjL | i hope if a doctor thinks they can only intubate me without sedation, they have a little mercy and just kill me quickly instead | 01:05 |
| de-facto | 163k daily new *detected* cases in a perfect exponential | 01:05 |
| xrogaan | ouch | 01:05 |
| xrogaan | Did people gave up in India? | 01:06 |
| de-facto | .title https://imgur.com/a/wXnwsrH https://i.imgur.com/rhyMyrt.png source http://metrics.covid19-analysis.org/ | 01:08 |
| Brainstorm | de-facto: From imgur.com: COVID-19: India Reproduction Rt and daily new Cases - Album on Imgur | 01:08 |
| de-facto | Rt ~ 1.37 | 01:08 |
| de-facto | hence doubling each t2 = ts ln(2) / ln(Rt) = 5.2 ln(2) / ln(1.37) = 11.4 days now at 163k daily | 01:09 |
| de-facto | .title https://www.covid19india.org/ | 01:10 |
| xrogaan | We have people here in Belgium, mostly working in restoration, who can't bear it any longer. | 01:23 |
| xrogaan | Wants to reopen. | 01:24 |
| xrogaan | I wish politics were clear from the start: "Be ready to lose your business." | 01:26 |
| LjL | would that have helped? | 01:27 |
| xrogaan | Instead of "We'll see in a month or two"? Maybe. | 01:27 |
| LjL | i guess. i'm for transparency, but i'm not really sure politicians *knew* | 01:28 |
| LjL | they've shown they can be pretty clueless | 01:28 |
| xrogaan | As soon as we refer to an epidemic as a pandemic, things are pretty dire. | 01:31 |
| xrogaan | There is one episode in Belgium where one political man seemed to have grasped the problem, it was during last November. He stated "we're less than a week before collapse of the healthcare system." Meaning we wouldn't be able to treat everybody. | 01:33 |
| xrogaan | Only one I heard refer to the pandemic in these terms too. | 01:34 |
| LjL | i've heard that several times, though i guess more from presumed pundits than politicians | 01:34 |
| Timvde | xrogaan: if they say that, people will probably respond with "hell no, then I'll just open, I rather go down fighting" | 01:37 |
| xrogaan | That's unreasonable. | 01:38 |
| Timvde | It is, but people are unreasonable :) | 01:38 |
| xrogaan | The reason there was a surge was because people went out with each other. | 01:38 |
| LjL | the reason there is currently a surge in India is most likely because there have been more infectious variants bred | 01:38 |
| LjL | i'm wary of oversimplifying things to "people went out with other people" | 01:39 |
| LjL | i'm sure they do, i'm sure it cause contagion, but there are studies that can't even figure out whether strong restrictive measures are measurably doing something | 01:39 |
| LjL | right now it goes on, but without public, except i believe public will be allowed again experimentally for... something... | 01:40 |
| xrogaan | To be clear, I was referring to Belgium and last November. I don't know about India. | 01:41 |
| LjL | err, the last line was for the wrong channel | 01:41 |
| LjL | xrogaan, yes, i get it, but since we started talking about India, and since you initially asked "did we just give up on India", i'm just pointing out things are not always what they seem | 01:42 |
| LjL | i don't think anyone in India gave up per se | 01:42 |
| xrogaan | No, no, did Hindu people gave up on safety. | 01:42 |
| xrogaan | Why would "we" give up on India? | 01:43 |
| xrogaan | Probably bad phrasing on my part, sorry. | 01:43 |
| xrogaan | Lots of people on the continent, we don't know how effective the measures have been. Or even if they were followed everywhere. | 01:44 |
| xrogaan | And then people travel. Which blow my mind, by the way, allowing people to travel during a pandemic. | 01:45 |
| xrogaan | I don't mean work related travel. I mean pleasure travel, or people going to live in the countryside for a couple of month in order to avoid the administrative restrictions of the local city. | 01:46 |
| xrogaan | I guess it's the difficult part of coming up with appropriate directives, huh? | 01:50 |
| de-facto | governments are much to weak, always thinking they can get away with some sort of compromise, yet reality proves them wrong everytime despite them still ignoring that scientists told them for MONTHS exactly what would happen. and with exactly i mean within single percentage precision | 02:04 |
| de-facto | to be really honest i am quite pissed at government in Germany | 02:05 |
| de-facto | Ministers agreed on implementing an emergency break, locally closing down high incidence regions six (!!!) weeks ago and what happened? they just ignored the agreement and instead tried to raise the threshold | 02:06 |
| de-facto | thats how we end up where we are right now | 02:06 |
| de-facto | that its not worse is only due to at least some of the population working hard on containment beyond the mandatory measures, because containment by government is MUCH too weak and everyone (including government) knows that | 02:09 |
| de-facto | the majority seems to wish for more containment for everyone, because some asocial minority happily ignores the containment necessities sabotaging the effort of the majorities, namely some exceptionally stupid and reckles people gathering under the name Querdenker | 02:11 |
| de-facto | they openly refuse to wear masks and attack press and police, try to break any rule like stupid little kids disobeying their parents or such while thinking they are extra cool because of that, without realizing how exceptionally stupid they appear in the eyes of the majority of people understanding we only can win this by working together on success | 02:14 |
| de-facto | last year we had a whole different spirit of working together, i remember open windows and people playing their instrument, or in the evening applauding the medical personal | 02:18 |
| de-facto | maybe we have to remember that we all sit in one boat with this, that the ONLY way we can win by regaining control is by working TOGETHER on this, including even the Querdenker et al | 02:20 |
| de-facto | and that also means that every country worldwide, even the most remote places or poorest countries have to get their full supply of up-to-date and state-of-the-art vaccines, globally and *at the same time* | 02:21 |
| de-facto | there is not other way out of this | 02:22 |
| de-facto | why dont we have vaccine factories being build everywhere? | 02:23 |
| Brainstorm | New from r/WorldNews: worldnews: In Brazil, Covid-19 is killing babies and children at an alarming rate → https://is.gd/mfUd9Y | 02:24 |
| de-facto | not just a few, but MANY so at least some will reach a productive state? | 02:24 |
| de-facto | i dont care anyone whining about technical difficulties, i simply dont buy it anymore, such challenges are there to be fucking solved, and i did not hear or read about one single reason that convinced me that it should not be possible to build more factories and supply chains | 02:25 |
| de-facto | if there is a market, why not satisfy it with production capacity? | 02:25 |
| xrogaan | My guess is that people aren't dying in droves, so it's not a "real" emergency for most. | 02:26 |
| finely[m] | <de-facto "governments are much to weak, al"> People who rise to the top is governments spend their lives negotiating and trying to bend the world to their will. With climate change, you cannot negotiate with the laws of physics. With COVID, you cannot negotiate with biology. | 02:26 |
| xrogaan | It's more akin to an inconvenient. | 02:26 |
| de-facto | finely[m], 100% ack | 02:27 |
| de-facto | every single compromise, without any exception, works IN favor of the pathogen | 02:27 |
| de-facto | or global warming | 02:28 |
| de-facto | that is an even MUCH bigger problem than this pandemic, it cant simply be addressed by solving a technical problem such as production capacity or such | 02:29 |
| de-facto | but lobbyist infiltrated governments are just happily ignoring even more consequently to address it | 02:29 |
| finely[m] | * People who rise to the top in governments spend their lives negotiating and trying to bend the world to their will. With climate change, you cannot negotiate with the laws of physics. With COVID | 02:30 |
| finely[m] | you cannot negotiate with biology. | 02:30 |
| finely[m] | As for the anti mask / anti lockdown groups - Who wants to bet Russians disinfo operations and Facebook's sociopathic algorithms that prioritise 'engagement' over all else are behind most of it? | 02:30 |
| finely[m] | Yep. | 02:31 |
| de-facto | sad thing is those who have the goal to divide society slowly but steadily are gaining more and more success, this is quite a dangerous trend imho | 02:32 |
| de-facto | not even government seems to be able to stick together in agreeing how to address the issues with a common strategy | 02:34 |
| de-facto | imho the window of time for a success story is closing, slowly but steadily | 02:35 |
| de-facto | we really need to have some positive feedback, some success, something that we achieved together and something we can be proud of, this will generate the spirit that together we are able to crush covid and reconquer our individual freedom again | 02:37 |
| xrogaan | Normalcy bias. People in general don't want things to change. So if you introduce a rapidly evolving offending vector that requires drastic measures to combat it, there will be some resistance. | 02:37 |
| de-facto | yet with a extremely aggressive containment strategy the success would be the biggest and containment the shortest | 02:39 |
| de-facto | in contrast to having that doing "barely enough to contain it" approach, that only wastes 1) life, 2) time 3) money 4) resources etc | 02:40 |
| de-facto | its a huge demoralization to do "barely enough" hence having "never success" without any perspective to end it | 02:40 |
| de-facto | people have to be given realistic perspectives and see the success to motivate their participation | 02:41 |
| de-facto | like a self fulfilling prophecy gaining momentum towards achieving containment success and crushing covid in a combined effort | 02:42 |
| de-facto | but that means that management would have to show enough courage and determination to kickstart it with the appropriate aggressive power to get the ball rolling into the direction that everyone would wish for: 100% against SARS-CoV-2 to get rid of this damn thing. | 02:44 |
| Brainstorm | New from Virology.ws: SARS-CoV-2 variant B.1.1.7 is not more virulent: When the B.1.1.7 variant of SARS-CoV-2 was first detected in the UK in December 2020 it was accompanied by unsubstantiated claims of increased transmissibility and virulence. The results of a hospital-based study in London reveals no association of the variant with severe disease in [... want %more?] → https://is.gd/KHAJEz | 03:15 |
| de-facto | question is by which selection: more severe per infection or more severe per hospitalization, how many hospitalizations per infection? | 03:24 |
| de-facto | .title https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00170-5/fulltext | 03:29 |
| Brainstorm | de-facto: From www.thelancet.com: The Lancet | The best science for better lives | 03:29 |
| LjL | de-facto, if it's referring to the study i saw, it's just same severity per hospitalization, without regard to how many hospitalizations it causes | 03:30 |
| de-facto | i dont understand the purpose of their approach | 03:30 |
| LjL | also "unsubstantiated claims", seriously? | 03:30 |
| de-facto | "In this cohort study, samples positive for SARS-CoV-2 on PCR that were collected from Nov 9, 2020, for patients acutely admitted to one of two hospitals..." | 03:30 |
| LjL | maybe they were unsubstantiated in december | 03:30 |
| LjL | they're quite substantiated now | 03:30 |
| LjL | de-facto, well i guess it's useful to project how manu ICU beds you will need given a number of patients coming in | 03:30 |
| LjL | but it says nothing about disease severity in general | 03:31 |
| de-facto | example: ignoring that B.1.1.7 is more reproductive (hence causing more infections), if each 100 infections by B.1 (e.g. D614G) would cause X hospitalizations and 100 infections by B.1.1.7 would cause 1.64 * X hospitalizations, then for each hospitalization (with either variant) it would be Y fatal outcomes all in all it would mean 100 B.1.1.7 infections would cause 1.64 * Y fatal outcomes, right? | 03:35 |
| de-facto | (i dont know if that is the case, but they surely would not see it by *only* looking at hospitalized patients like with such a study above) | 03:36 |
| de-facto | and if initial infection dose plays a role in disease severity, why would increased pathogen reproduction assumed to not play a role in disease severity? | 03:38 |
| de-facto | after all its got the character of an (exponential) race condition, pathogen reproduction versus immune response containment or even neutralization, not too much unlike trying containment of a more reproductive VoC (e.g. B.1.1.7) with the same containment rules that contained B.1 (as we see right now that does not work) | 03:40 |
| de-facto | hence i would assume its quite plausible that 1) B.1.1.7 is more reproductive in a population of non-immunized individuals 2) B.1.1.7 is more reproductive on a cellular level 3) B.1.1.7 infection more often leads to a severe progression | 03:41 |
| Brainstorm | New from The Indian Express: World: Australia considers staggered reopening of borders to allow people fully vaccinated against Covid-19 to travel → https://is.gd/wzcOJV | 03:56 |
| de-facto | ^^ that would be an interesting trial | 04:00 |
| LjL | <Brainstorm> New from r/WorldNews: worldnews: Chile sees Covid surge despite vaccination success → https://is.gd/WDWb3Y | 04:00 |
| de-facto | https://www.worldometers.info/coronavirus/country/australia/ ~10-ish daily new infections in Australia or such | 04:01 |
| de-facto | LjL, "More than 93% of the doses administered in Chile so far have been CoronaVac, produced by the Beijing-based biopharmaceutical company Sinovac." | 04:03 |
| LjL | yep | 04:03 |
| de-facto | "Data on the efficacy of the CoronaVac vaccine is varied. Brazilian trials suggested an efficacy rate of around 50.4% but results from late-stage trials in Indonesia and Turkey suggested a much higher rate - between 65% and 83%." | 04:03 |
| de-facto | Question: which is the VoC circulating in Chile? | 04:03 |
| de-facto | possibly P.1 or P.2? | 04:03 |
| de-facto | people (including the author of that article) have to understand that vaccination success with current gen vaccines depend on the VoC that it is used against (unfortunately) | 04:05 |
| de-facto | P.1 https://cov-lineages.org/global_report_P.1.html | 04:07 |
| de-facto | also in https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---23-march-2021 | 04:10 |
| de-facto | although Chile is not near group immunity anyhow https://ourworldindata.org/covid-vaccinations | 04:11 |
| de-facto | so yeah that whole article is ,,, hhmm | 04:11 |
| kreyren | %cases australia | 05:01 |
| Brainstorm | kreyren: In Australia, there have been 29350 confirmed cases (0.1% of the population) and 909 deaths (3.1% of cases) as of 10 days ago. 16.0 million tests were performed (0.2% positive). Fatality can be broadly expected to lie between 1.9% (assuming prevalence as in tests) and less than 3.3% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=Australia for time series data. | 05:01 |
| Brainstorm | New from Reddit (test): Virus shedding in vaccinated population [looking for data]: Hello Seems like israel vaccination campaign is decaying the virus population, but as more people become asymmetric (at least in the short term) virus shedding in waste water becomes more critical in assessing the true proliferation of strains. There is a waste water [... want %more?] → https://is.gd/eRviIl | 05:07 |
| Brainstorm | New from EurekAlert!: Triangular-shaped spikes key to coronavirus transmission, finds new study: Scientists have modeled the spikes of the coronavirus particle to unravel how their shape and number may influence the transmissibility of the virus. → https://is.gd/0R7JrR | 06:30 |
| Brainstorm | New from r/WorldNews: worldnews: Tokyo Olympics must be 'reconsidered' due to Japan's failure to contain pandemic → https://is.gd/eR6Rkh | 07:31 |
| Brainstorm | New from The Indian Express (Health): Health: Dry mouth and covid tongue: Coronavirus symptoms you must not ignore → https://is.gd/RbrjPW | 08:02 |
| Brainstorm | New from r/WorldNews: worldnews: Hundreds of people throw cow dung on each other as part of a local festival in India. Meanwhile, India records over 200,000 #covid cases over the last 24 hours. → https://is.gd/nxhOSQ | 08:53 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | April 16, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/tsORHc | 09:04 |
| Blankspace | Hi | 09:35 |
| Haley[m] | %cases France | 09:37 |
| Brainstorm | Haley[m]: In France, there have been 5.0 million confirmed cases (7.4% of the population) and 98131 deaths (2.0% of cases) as of 3 days ago. 68.0 million tests were performed (7.3% positive). See https://offloop.net/covid19/?default=France for time series data. | 09:37 |
| Blankspace | %cases India | 09:38 |
| Brainstorm | Blankspace: In India, there have been 13.1 million confirmed cases (1.0% of the population) and 167569 deaths (1.3% of cases) as of 3 days ago. 254.0 million tests were performed (5.1% positive). Fatality can be broadly expected to lie between 0.2% (assuming prevalence as in tests) and less than 1.4% (considering only deaths and recoveries). See https://offloop.net/covid19/?default=India for time series data. | 09:38 |
| Brainstorm | New from Medical Xpress: Reliable COVID-19 short-term forecasting: A new study by Texas A&M University researchers published in PLOS ONE details a new model for making short-term projections of daily COVID-19 cases that is accurate, reliable and easily used by public health officials and other organizations. → https://is.gd/qKTNx1 | 09:46 |
| Brainstorm | New from Medical Xpress: Pfizer CEO: Vaccine third dose 'likely' needed within 12 months: The head of Pfizer said in an interview aired Thursday that people will "likely" need a third dose of his company's COVID-19 shot within six to 12 months of vaccination, while elsewhere defending the relatively higher cost of the jab. → https://is.gd/kj3ovG | 10:07 |
| oneno[m] | Are all of you familiar with the Billy Meier [**coronavirus Contact Reports**](https://www.figu.org/ch/index/downloads/coronavirus/eng) ? | 10:25 |
| oneno[m] | Information on the [**coronavirus pathology**](https://www.figu.org/ch/files/downloads/coronavirus/014_where_the_coronavirus_eng.pdf) discussed privately in November 2019 was officially released January 6, 2020 | 10:33 |
| oneno[m] | The [**first detailed coronavirus information**](https://www.figu.org/ch/files/downloads/coronavirus/004_new_vital_information_about_the_coronavirus_and_other_interesting_news_eng.pdf) was published February 3, 2020 with a [**continuation**](https://www.figu.org/ch/files/downloads/coronavirus/005_new_vital_information_about_the_coronavirus_continuation_from_contact_report_731_eng.pdf). | 10:34 |
| oneno[m] | Information [**about wearing a mask**](https://www.figu.org/ch/files/downloads/coronavirus/010_what_there_is_to_know_eng.pdf) appeared March 2, 2020 with [**detailed information**](https://www.figu.org/ch/files/downloads/coronavirus/021_741_contact_eng.pdf) appearing May 30, 2020. The [**necessity to remove masks from time-to-time for 10-15 minutes for lung | 10:36 |
| oneno[m] | recovery**](https://www.figu.org/ch/files/downloads/coronavirus/040_and_still_more_to_say_of_importance_eng.pdf) appeared sometime in January 2021. | 10:36 |
| oneno[m] | Information on the [**maliciousness of the coronavirus**](https://www.figu.org/ch/files/downloads/coronavirus/015_about_the_maliciousness_of_the_coronavirus_eng.pdf) appeared April 20, 2020. | 10:37 |
| oneno[m] | Information on the [**modes of behavior**](https://www.figu.org/ch/files/downloads/coronavirus/016_modes_of_behaviour_eng.pdf) appeared May 10, 2020 with [**additional information**](https://www.figu.org/ch/files/downloads/coronavirus/017_info_about_further_necessary_eng.pdf) appearing May 22, 2020. | 10:38 |
| oneno[m] | A [**listing**](https://www.figu.org/ch/files/downloads/coronavirus/024_damage_that_can_be_caused_by_the_coronavirus_eng.pdf) on the damage that can be caused by the coronavirus appeared June 16, 2020 together with an [**addendum**](https://www.figu.org/ch/files/downloads/coronavirus/026_latest_corona-research_cognitions_eng.pdf) clarifying that a recovery from infection does not necessarilly mean effective healing. | 10:39 |
| oneno[m] | [**New safety and preventive regulations**](https://www.figu.org/ch/files/downloads/coronavirus/025_further_important_recommendations_eng.pdf) against the risk of infection by the coronavirus appeared July 26, 2020. | 10:40 |
| oneno[m] | A [**summary**](https://www.figu.org/ch/files/downloads/coronavirus/035_up-date_corona_eng.pdf) of coronavirus information appeared on December 3, 2020. | 10:40 |
| oneno[m] | [**Background information**](https://www.figu.org/ch/files/downloads/coronavirus/036_background_information_eng.pdf) on the coronavirus was published December 11, 2020 with nearly 15 million victims since biolab escape in 1981. | 10:41 |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/UflgslPZHMxHUmKNPEDmQnUX/message.txt > | 10:43 | |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/lofdEzGIWPZeQmCLroHfApcv/message.txt > | 10:45 | |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/GXBPnExFYFBZIFNZNdBFpgoN/message.txt > | 10:46 | |
| -RSSBot[LjLmatrix- Feed: Conferenza stampa del Presidente Draghi ( http://www.governo.it/it/articolo/conferenza-stampa-del-presidente-draghi/16645 ) | 10:46 | |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/FqobLtCybeTkSCwNCejnBUdR/message.txt > | 10:46 | |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/iPOjDTiHgDdYjEBudQliAmXJ/message.txt > | 10:47 | |
| Brainstorm | New from StatNews: Next-generation Covid-19 vaccines are supposed to be better. Some experts worry they could be worse: Some scientists are increasingly concerned that, because of a quirk of our own biology, future iterations of Covid-19 vaccines might not always be quite as effective as they are today. → https://is.gd/gc3we2 | 10:48 |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/AOZOltKHTqjNpxfVwdqwhQVn/message.txt > | 10:48 | |
| oneno[m] | <Brainstorm "New from StatNews: Next-generati"> [**CR767**](https://theyflyblog.com/2021/04/767th-contact-various-organic-long-term-damages-and-lifelong-suffering/): | 10:52 |
| * oneno[m] < https://matrix.org/_matrix/media/r0/download/matrix.org/CaWmgKaqdWNvdevnEpDJsWVd/message.txt > | 10:54 | |
| Brainstorm | New from StatNews: Biotech: ‘We did need to throw a lot of spaghetti against the Covid window’: a biotech analyst on pandemic drug development → https://is.gd/4JLkpX | 10:58 |
| mobidrop | I'd rather not get injected with spaghetti | 10:58 |
| oneno[m] | <mobidrop "I'd rather not get injected with"> What will you do if denied access to grocery stores, banks, ... | 11:00 |
| mobidrop | I'll make my own spaghetti | 11:00 |
| oneno[m] | <mobidrop "I'll make my own spaghetti"> Where will you get the flour / veggies from? | 11:01 |
| mobidrop | I got family who's already vaxed, I can get them to buy the ingredients | 11:02 |
| mobidrop | maybe I'll go to the market, I can't imagine them checking health status | 11:03 |
| oneno[m] | Can survive on Greek salad and pitta bread. So need to be able to grow veggies for Greek salad at home year-round and stock-up on pita bread. | 11:04 |
| oneno[m] | Also need to get 5-years supply of olives. | 11:05 |
| mobidrop | in a free market people will sell to others regardless of their health status | 11:09 |
| Brainstorm | New from Politico: Coronavirus: COVID-19 to ‘become like flu’ thanks to vaccines, Pfizer CEO says → https://is.gd/IxST4I | 11:18 |
| mobidrop | lmaooooo ^ | 11:22 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Vaxzevria (previously COVID-19 Vaccine AstraZeneca), COVID-19 Vaccine (ChAdOx1-S [recombinant]), COVID-19 virus infection, Date of authorisation: 29/01/2021, Revision: 5, Status: Authorised → https://is.gd/rIyUV1 | 11:39 |
| mithri | hey folks | 12:02 |
| mithri | have you looked into Iranian vaccines under dev? | 12:02 |
| mithri | they are apparently working on 3 vaccines | 12:02 |
| Brainstorm | New from The Indian Express: World: Indonesia could reopen Bali beaches to foreigners by July end → https://is.gd/qR97e4 | 12:11 |
| Brainstorm | New from EMA: What's new: Document: COVID-19 vaccine safety update for COVID-19 Vaccine Janssen: 14 April 2021 → https://is.gd/utyAOe | 12:52 |
| CoronaBot | /r/covid19: Ten scientific reasons in support of airborne transmission of SARS-CoV-2 (81 votes) | https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00869-2/fulltext | https://redd.it/mrrtcu | 13:43 |
| Brainstorm | New from BMJ: Covid-19: Irish GP who refused to vaccinate patients is suspended: An Irish GP who refused to vaccinate his patients against SARS-CoV-2 and referred to media information about the pandemic as “propaganda” and a “hoax” has been suspended from the medical register by... → https://is.gd/yoGy7x | 13:44 |
| Brainstorm | New from BMJ: Covid-19: NHS will take at least a year and a half to recover, doctors warn: Most doctors think that the NHS will take at least 18 months to recover from the pandemic, a survey of members of the Royal College of Physicians (RCP) has found.The college sent a survey to 25 500... → https://is.gd/c8jhdz | 13:54 |
| Brainstorm | New from The Indian Express (Health): Health: COVID-19 services: Find out how you can avail them at home → https://is.gd/HmOqtF | 14:05 |
| Brainstorm | New from BMJ: Covid-19: US reports low rate of new infections in people already vaccinated: The US Centers for Disease Control and Prevention knows of about 5800 “breakthrough” infections of SARS-CoV-2 so far among the roughly 77 million people in the country who have been fully vaccinated,... → https://is.gd/mCdU6z | 14:26 |
| Brainstorm | New from The Indian Express: World: UK finds 77 cases of Covid-19 variant first found in India → https://is.gd/1NsITN | 14:37 |
| Brainstorm | New from EMA: What's new: Document: Vaxzevria (previously COVID-19 Vaccine AstraZeneca) : EPAR - Product information → https://is.gd/YtvmMR | 14:48 |
| Brainstorm | New from Medical Xpress: Pressure on Spain govt to extend state of emergency: With infections again on the rise and Europe's vaccine rollout delayed over clotting concerns, the Spanish government is under pressure to extend a state of emergency to fight the pandemic. → https://is.gd/vUxclB | 15:53 |
| Brainstorm | New from The Indian Express: World: Global Covid-19 wrap: Growth in cases worrying, says WHO; Tokyo Olympics head assures safe conduct of games → https://is.gd/RAzwG3 | 16:04 |
| Brainstorm | New from The Indian Express: World: China to build more bio labs amidst questions over Wuhan lab’s role in COVID-19 origin → https://is.gd/gGLHi7 | 16:15 |
| Brainstorm | New from The Indian Express: World: ‘Strong evidence’ Covid-19 predominantly spreads through air: report → https://is.gd/4AeddM | 16:37 |
| Brainstorm | New from Reddit (test): nCoV: Australia reports first blood clot death 'likely' linked to AstraZeneca vaccine → https://is.gd/FshVmB | 16:47 |
| Brainstorm | New from EMA: What's new: Medicine: Veterinary medicines European public assessment report (EPAR): Prevexxion RN, Marek's disease vaccine (live recombinant), Date of authorisation: 20/07/2020, Status: Pending → https://is.gd/rvjxeO | 17:08 |
| Brainstorm | New from Medical Xpress: COVID-19: Does exercising really reduce the risk?: A new US study shows that people who are less physically active are more likely to be hospitalized and die with COVID-19. According to these new calculations, being inactive puts you at a greater risk from COVID-19 than any other risk factor except age and having had an organ [... want %more?] → https://is.gd/dvUHo5 | 17:41 |
| Brainstorm | New from BBC Health: Covid vaccine advice for pregnant women firmed up: They should be offered a jab in line with their age group, the UK's vaccine advisors recommend. → https://is.gd/dGvru9 | 18:13 |
| Brainstorm | New from Medical Xpress: Closing the COVID vaccine gap: Small clinics at churches and apartment buildings reach vulnerable residents: Joanne Bennet eagerly slipped off the blue jacket covering her right arm so a nurse could inject a dose of COVID-19 vaccine. Bennet was all smiles, despite a dislike of needles, sitting in a chair in a community room of [... want %more?] → https://is.gd/4tfU1J | 19:15 |
| Brainstorm | New from Medical Xpress: Does COVID test positivity still matter? Vaccines are upending trusted virus metrics: About four out of every 10 Floridians have received at least one dose of a COVID vaccine—a shift in the pandemic landscape that has upended the meaningfulness of various statistics that health experts, government officials and the public [... want %more?] → https://is.gd/qm8P8D | 19:25 |
| Blankspace | Hey | 19:53 |
| LjL | why wouldn't test positivity *not* matter, what are they on about | 20:19 |
| LjL | yeah i know i could read it | 20:19 |
| LjL | but i won't | 20:20 |
| LjL | de-facto, the argentinian paper about carrageenan spray is finally out https://www.medrxiv.org/content/10.1101/2021.04.13.21255409v1 | 20:23 |
| de-facto | nice one, 5-fold is quite something, yet more participants would be nice to get better stats | 20:38 |
| de-facto | COVID infections 2/196 in verum and 10/198 in placebo group | 20:39 |
| de-facto | efficacy would therefore be like ((10÷198)−(2÷196))÷(10÷198) ~ 79% | 20:41 |
| de-facto | but yeah 2 is quite a low number there, they should repeat that study with one or two orders of magnitude more participants | 20:42 |
| CoronaBot | /r/covid19: Indoor Air Changes and Potential Implications for SARS-CoV-2 Transmission (80 votes) | https://jamanetwork.com/journals/jama/fullarticle/2779062 | https://redd.it/ms6aor | 20:46 |
| LjL | de-facto, unfortunately though, while they report a risk reduction of 95%, the confidence interval of that is from 6% to 99.7% | 20:47 |
| LjL | i guess some people would call that meaningless | 20:47 |
| Brainstorm | New from Politico: Coronavirus: Italy to ease coronavirus restrictions ahead of schedule → https://is.gd/I3Rea5 | 20:48 |
| de-facto | individual relative risk would therefore be (2÷196)÷(10÷198) ~ 20% | 20:48 |
| de-facto | but yeah their stats would have to get more participants, the numbers of cases are just too low | 20:49 |
| LjL | yet, 400 people is not a small study when it comes to pre-existing cheap drugs | 20:49 |
| LjL | i mean, yes, it's a small study in terms of its statistical power | 20:50 |
| de-facto | yeah but the covid cases in each arm are the real measure | 20:50 |
| LjL | but in many other cases we don't even get that | 20:50 |
| LjL | de-facto, well it says it was during a period of peak incidence | 20:50 |
| de-facto | because they always are much less than the participants, hence the limiting factor for the accuracy of their quotients there | 20:50 |
| de-facto | yeah hence if it already was during peak incidence they would need much more participants in order to reach enough covid cases in each arm | 20:51 |
| de-facto | imagine the vaccination trials? | 20:51 |
| de-facto | they had to wait until they accumulated enough covid cases in the vaccine arm to get meaningful stats | 20:51 |
| LjL | "Statistical analysis: We estimated that 200 participants would need to be enrolled in each group to give the trial approximately 80% power, at two-sided type I error rate of 5%, to show that COVID-19 would be 50% lower in active treatment group than in the placebo." | 20:52 |
| LjL | imagine running the vaccination trial without the financial incentives they got, though | 20:52 |
| LjL | it just wouldn't happen | 20:52 |
| LjL | this was financed by the Argentinian government but i assume the amount of money allocated to it was marginal | 20:53 |
| LjL | i'd say it has better evidence than HCQ and is cheap and accessible to anyone | 20:53 |
| de-facto | example: (2÷196)÷(10÷198) ~ 20%; (3÷196)÷(10÷198) ~ 30%; (4÷196)÷(10÷198) ~ 40% | 20:53 |
| de-facto | it just depends too much on that small number there | 20:54 |
| LjL | i understand | 20:54 |
| LjL | but what are the chances that you'd get 2 vs 10, in reality, this spray doing nothing, i.e. being equivalent to placebo? | 20:54 |
| LjL | i think the degree of efficacy is unclear, not good enough statistics, but the *presence* of some efficacy seems semi-convincing | 20:55 |
| de-facto | it depends on how much the expectation value of covid infections spreads, i.e. how accurate or "stable" those two infections there reflect the reality | 20:55 |
| LjL | it's a controlled environment, with health workers instructed to keep using PPE and other hygiene procedures as standard | 20:56 |
| LjL | i think that's a good aspect of the trial | 20:56 |
| de-facto | yes the numbers look promising, but for more certainty they would need to have 10-fold or 100-fold the number of participants | 20:56 |
| LjL | i agree. but for me to just keep buying this spray and have some confidence in it, this is enough, also considering it's already on the market with no known side effects :P | 20:57 |
| de-facto | imagine the distribution of each of such values to be normal distributed (that gauss peak like shape) | 20:57 |
| de-facto | how "sharp" is it around its maximum? | 20:57 |
| de-facto | hard to tell for such low numbers as 2 cases | 20:58 |
| de-facto | but already better to tell if those were 20 or even 200 | 20:58 |
| LjL | i guess now i'll be interested in seeing if it passes peer review | 20:59 |
| de-facto | btw how does it feel to spray that into the nose? | 20:59 |
| LjL | like any nasal spray | 20:59 |
| LjL | it could just be saline, it would feel no different | 20:59 |
| de-facto | does it have any taste or smell? does it inhibit sense of smell? | 21:00 |
| LjL | i feel i sometimes get a bit of headache from it, but i think i have sinusitis and it's mostly just the fact i'm inhaling storngly | 21:00 |
| LjL | no | 21:00 |
| de-facto | does it feel like covering the mucus with some layer or something or such? | 21:00 |
| LjL | no, i don't get any particular feeling. my mom, who bought a slightly different version that also contains k-carrageenan (this study was with iota-carrageenan), says it helps keep the nose from drying up too much | 21:01 |
| de-facto | oh so it even got some benefit in addition to its protective effect, thats nice | 21:02 |
| LjL | there's also some circumstantial evidence: it has shown some ability to shorten cold-type infections, and it has shown in-vitro ability to inhibit SARS-COV-2 | 21:02 |
| de-facto | nice | 21:02 |
| LjL | de-facto, yes, that's why it's on the market, as a "cold aid" and in the k version, also a moisturizer sort of thing | 21:02 |
| LjL | i also sent this paper to Doc btw, curious if i get any reaction | 21:03 |
| de-facto | yeah he found something similar with Hydroxypropyl-methylcellulose or such, right? | 21:07 |
| LjL | not sure, he definitely was interested in carrageenan itself, from in vitro studies | 21:08 |
| Brainstorm | New from Scientific American: Coronavirus News Roundup, April 10--April 16: Pandemic highlights for the week -- Read more on ScientificAmerican.com → https://is.gd/SWRcmF | 21:09 |
| LjL | also i'd like him to come back and i thought maybe if i show him studies that he's probably interested in he'll see i have no ill feelings towards him... or not, i dunno, i just know i'm disappointed he left but i also can't let people call other people pathetic if i'm an op in a channel | 21:09 |
| de-facto | yeah me neither, I also am not mad at him or such, i just would wish for mutual respect | 21:16 |
| de-facto | btw LjL have found something interesting, what do you think about this paper her? | 21:16 |
| de-facto | .title https://science.sciencemag.org/content/371/6536/1379 | 21:16 |
| Brainstorm | de-facto: From science.sciencemag.org: Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets | Science | 21:16 |
| de-facto | "The authors tested the performance of the lipoproteins as a preexposure prophylactic in a ferret-to-ferret transmission study. Intranasal administration of the peptide 2 days before cohousing with an infected ferret for 24 hours completely protected animals in contact from infection and showed efficacy against mutant viruses. Because ferrets do not get sick from SARS-CoV-2, disease prevention could not be tested in this model." | 21:17 |
| de-facto | "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion between the viral and host cell membranes, which is mediated by the viral spike protein. We have designed lipopeptide fusion inhibitors that block this critical first step of infection and, on the basis of in vitro efficacy and in vivo biodistribution, selected a dimeric form for evaluation in an animal model." | 21:18 |
| de-facto | "Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour cohousing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and thus may readily translate into safe and effective intranasal prophylaxis to reduce transmission of SARS-CoV-2." | 21:18 |
| LjL | de-facto, can't see the full text... but i guess the main problem of all these many proposed treatments is always the same, being able to make a big enough study on actual humans. and then, i guess, being able to mass-produce the substance. in the case of carrageenan at least that part is made better by the fact it's already mass-produced | 21:18 |
| LjL | but of course it may be less effective than something studied for the specific purpose of inhibiting the S-protein | 21:18 |
| de-facto | .title https://www.biorxiv.org/content/10.1101/2020.11.04.361154v1.full | 21:19 |
| Brainstorm | de-facto: From www.biorxiv.org: Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets | bioRxiv | 21:19 |
| de-facto | there is the associated preprint in full text | 21:19 |
| LjL | oh fun, it's just paywalled on sciencemag | 21:20 |
| LjL | i think this kind of drug would have been invaluable to healthcare workers before vaccines were available to them | 21:21 |
| LjL | maybe now it's not as important... although it probably depends a lot on the place | 21:21 |
| LjL | i mean, in italy even though we're not ahead with vaccines, medical personnel are definitely all vaccinated by now | 21:22 |
| de-facto | i think it still may be of great value since as a fusion inhibitor it probably also can be used when its "already too late" e.g. with ongoing infection | 21:22 |
| de-facto | although they could not test that there because it seems it completely prevented infections in their ferret models | 21:23 |
| de-facto | (ferrets are commonly used as model for human respiratory diseases) | 21:23 |
| de-facto | also this probably is not VoC specific (i guess) | 21:24 |
| de-facto | "This dimeric cholesterol-conjugated peptide ([SARSHRC-PEG4]2-chol; red line in Fig. 1d) is the most potent lipopeptide against SARS-CoV-2 that has been identified thus far." | 21:26 |
| genera | wie funktioniert das? attachment to ACE-2 receptor? | 21:32 |
| de-facto | "The fusion process is mediated by the viral envelope spike glycoprotein, S. Upon viral attachment or uptake, host factors trigger large-scale conformational rearrangements in S, including a refolding step that leads directly to membrane fusion and viral entry (1–6). Peptides corresponding to the highly conserved heptad repeat (HR) domain at the C-terminus of the S protein (HRC peptides) may prevent this refolding and inhibit fusion | 21:33 |
| de-facto | , thereby preventing infection (7–12) (Fig. 1a-c)." | 21:33 |
| Arsanerit | My sister is a healthcare worker and is scheduled to be vaccinated next month with Janssen, if that's still going ahead. | 21:34 |
| de-facto | "Donor ferrets and 6/6 mock-treated recipient animals seroconverted on 21 DPI. None of the peptide-treated animals seroconverted, demonstrating that in-host virus replication was completely blocked by [SARSHRC-PEG4]2-cholJ (Fig. 4)." | 21:38 |
| de-facto | DPI = Days Post Infection | 21:38 |
| de-facto | "Based on the in vitro and in vivo results shown here, we expect that prophylactic intranasal administration of the [SARSHRC-PEG4]2-chol peptide prevents transmission from infected to uninfected individuals, even during a 24-hour period of intense direct contact. In vitro data suggest that this lipopeptide will be effective against emerging variants with mutations in S and possibly against other coronaviruses." | 21:39 |
| de-facto | btw they also mention another interesting paper: | 21:41 |
| de-facto | .title https://science.sciencemag.org/content/370/6515/426 | 21:41 |
| Brainstorm | de-facto: From science.sciencemag.org: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science | 21:41 |
| Brainstorm | New from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: April 16, 2021 → https://is.gd/uSkKbY | 21:51 |
| Brainstorm | New from FDA Press Releases: Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Monoclonal Antibody Bamlanivimab: Today, the FDA revoked the emergency use authorization that allowed for the investigational monoclonal antibody therapy bamlanivimab, when administered alone, to be used for the treatment of mild-to-moderate COVID-19 [... want %more?] → https://is.gd/1gNMVh | 22:43 |
| Brainstorm | New from r/WorldNews: worldnews: Ontario’s new COVID-19 restrictions include increased police powers, restricting gatherings → https://is.gd/S3oHH2 | 23:14 |
| de-facto | .title https://imgur.com/a/XuhXs7S https://i.imgur.com/sLZ2p0Z.png source: https://www.intensivregister.de/#/aktuelle-lage/zeitreihen ICU_COVID_Germany(2021-03-14 + t) = 2281.28 + 463.39 1.37^(t/5.2) = 2281.28 + 4.63.39 1.28^(t/4) | 23:35 |
| Brainstorm | de-facto: From imgur.com: COVID Germany: ICU beds occupied - Album on Imgur | 23:35 |
| de-facto | meaning in the exponential increase of ICU beds it would be Rt(4d) ~ 1.28 or Rt(5.2d) ~ 1.37 | 23:36 |
| de-facto | fortunately there is a "kink" in the curve from 2021-04-07 till today, so hopefully the exponential trend is somewhat broken, or its just eastern | 23:38 |
| de-facto | with a ICU bed reproduction of R>1 the ministers think its appropriate to not only ignore the emergency break but even open in some "model experiments" without scientific studies | 23:39 |
| de-facto | I hope federal government will force them to comply with containment | 23:40 |
| Brainstorm | New from Medical Xpress: Pfizer to send more COVID vaccines to Canada as Moderna jabs delayed: Prime Minister Justin Trudeau on Friday assured Canadians that the country's turbulent COVID-19 vaccine rollout remains on track after Pfizer agreed to boost shipments just as Moderna deliveries hit a snag. → https://is.gd/bwa4vn | 23:45 |
Generated by irclog2html.py 2.17.0 by Marius Gedminas - find it at https://mg.pov.lt/irclog2html/!
