nixonix | page 36 of that pdf, very large CI's, then theres very different for "any mrna" compared to pfizer - and moderna lacks data | 00:05 |
---|---|---|
nixonix | could it be that it lacks adjusted part, because its not approved for 12-15 yo i think | 00:06 |
nixonix | or under 18 it says | 00:07 |
nixonix | too bad they need to use VAERS where anyone could report anything | 00:09 |
nixonix | hey what german officials have found about myocarditis? or italy, france, any larger country? | 00:10 |
Brainstorm | Updates for Zimbabwe: +766 cases (now 43480), +1 deaths (now 1692) since 19 hours ago | 00:11 |
nixonix | proinflammatory cytokines in pulmonary circulation. funny it looks like its higher from moderna, when pfizer produces more those immune response side effects due to more type 2 helper t-cell associated cytokines | 00:15 |
nixonix | and moderna has more mrna, 100 vs 30 | 00:15 |
nixonix | although the confidence intervals are wide and mostly overlapping, so isnt much of a signal from anything | 00:15 |
de-facto | .title https://imgur.com/a/8RD3wyo https://i.imgur.com/vvH53DO.png | 00:17 |
Brainstorm | de-facto: From imgur.com: Myocarditis / Pericarditis to VAERS after mRNA-1273 - Album on Imgur | 00:17 |
de-facto | nixonix, there tried to overlay the graphs from the mRNA-1273 paper and todays CDC release about myocarditis (see the source links in the descripton) | 00:18 |
de-facto | .title https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-06/03-COVID-Shimabukuro-508.pdf | 00:20 |
Brainstorm | de-facto: From www.cdc.gov: CDC Awardee COVID-19 Vaccination Planning Meeting (Doughan, Rola N. (CDC/DDID/NCIRD/OD) (CTR)) | 00:20 |
de-facto | .title https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075 | 00:20 |
Brainstorm | de-facto: From academic.oup.com: Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients | Clinical Infectious Diseases | Oxford Academic | 00:20 |
de-facto | those two | 00:20 |
de-facto | I tried to align the graphs in the first 9 days because after that the scales differ | 00:21 |
nixonix | where was the original pic of those protein levels? supplementary material of that Circulating... paper? | 00:24 |
nixonix | or do i have old version without pics | 00:25 |
nixonix | ah found, i somehow skipped over it | 00:25 |
de-facto | last page of the paper | 00:25 |
nixonix | ok, it looks like it would correlate with S1 | 00:26 |
nixonix | but not quite. s1 is a bit later, and you would think its the symptoms that come with delay | 00:27 |
de-facto | yes correlate, might also have a common cause behind that (well at least the vaccine itself) | 00:27 |
nixonix | yeah, as it prob is, imo | 00:28 |
de-facto | yeah i am not sure if they count exactly the same, i also would say it somewhat correlates | 00:28 |
de-facto | not sure about age group etc pp, but timeframe and pattern fits i guess | 00:28 |
nixonix | id be interested in what other countries have found | 00:29 |
nixonix | large countries like uk, france germany italy | 00:29 |
nixonix | and do they know if similar doesnt appear with all or most other vaccines? | 00:31 |
nixonix | have they ever looked hard enough to see any signal? | 00:31 |
de-facto | also why are men so much more affected than woman? | 00:31 |
nixonix | men have stronger immune response | 00:31 |
de-facto | thats also some kind of hint to the under-laying process | 00:32 |
Brainstorm | New from r/WorldNews: worldnews: Seattle scientist digs up deleted coronavirus genetic data, adding fuel to the covid origin debate → https://is.gd/Xo1BfV | 00:32 |
nixonix | (if we go with my hypotheses, its just the immune response) | 00:32 |
de-facto | nope females have stronger auto-immune responses and also immune responses afaik | 00:32 |
nixonix | ..thesis | 00:32 |
de-facto | i dont think either is overexposed in side effects, but with this particular one men clearly are according to CDC dada | 00:33 |
de-facto | *data | 00:33 |
de-facto | so there must be some difference that causes this to occur more often in male than in female | 00:33 |
de-facto | (btw to be clear its extremely rare still, we just are discussing it out of interest, i am going to take my second Moderna without hesitation) | 00:35 |
Brainstorm | Updates for Tunisia: +3638 cases (now 391411), +95 deaths (now 14318) since 22 hours ago | 00:35 |
nixonix | there seems to be different information of strength of immune response between sexes. ill prob look at that more closely and see what i can find. innate immune response would be guilty in this case | 00:36 |
de-facto | yes or maybe something cellular as you said like ACE2 et al | 00:36 |
nixonix | and it seems to vary between viral infections, and parts of immune response | 00:38 |
nixonix | but generally its stronger for women | 00:39 |
de-facto | maybe there really is a mechanism linking that S1 with some receptors on heart muscle or such, but assuming there would be something like that, what would S1 dock onto there? | 00:40 |
de-facto | ACE2 and block it? | 00:40 |
Brainstorm | New from NPR: The Pandemic Led To The Biggest Drop In U.S. Life Expectancy Since WW II, Study Finds: Life expectancy fell by nearly 2 years between 2018 and 2020, largely due to COVID-19. Declines were most pronounced among minority groups, including Black and Hispanic people. → https://is.gd/McpGN6 | 00:42 |
de-facto | i dont know about heart muscle cells and their pathways | 00:42 |
nixonix | while the above is generally true, its mostly so that those important parts suppressing the infection are higher for women | 00:44 |
de-facto | hmm you know what speaks against that S1 myocarditis correlation there | 00:45 |
nixonix | but this wasnt the case, but about detrimental response, that might cause those myocardites | 00:45 |
de-facto | the myocarditis is mainly after second dose, the s1 after first dose (i think) | 00:45 |
nixonix | like: "These data indicated that innate inflammatory cytokines and chemokines are more robustly elevated early and throughout disease course in male patients over female patients | 00:45 |
de-facto | so that would unlink it | 00:45 |
nixonix | something like that i remembered, thats why i wondered for awhile how was it again (for sars2, that is) | 00:46 |
nixonix | s1 causing it would be far-fetched anyway (while should still be considered as a possibility, imo) | 00:47 |
de-facto | but why is myocarditis mainly after 2nd dose in young men? | 00:48 |
nixonix | why isnt ljl here speculating these with us? | 00:48 |
nixonix | well, those side effects come mostly from 2nd dose too | 00:49 |
nixonix | exp that slight shoulder pain | 00:49 |
nixonix | it looks like immune response caused, it walks like immune response... | 00:49 |
de-facto | from the paper "After the second vaccine dose, no S1 or spike was detectable, and both antigens remained undetectable through day 56." | 00:49 |
de-facto | so yeah forget about the S1 myocarditis link | 00:50 |
de-facto | i take everything back, yet glad i looked into it to find that detail | 00:50 |
de-facto | so it must be something else with the 2nd dose then | 00:51 |
LjL | uh i don't know | 00:51 |
nixonix | yeah its good to look at. also good to have arguments ready for anti-vaxers who are excited about s1 currently | 00:51 |
nixonix | glad they arent about nanoparticles, because thats much harder subject | 00:51 |
LjL | i remember i looked here a while ago and it looked like there was someone new and i was like "uh oh now i have to decide whether de-facto is discussing something constructive or arguing with someone who's just riling him up with anti-science idiocy" and so i decided to go do something else | 00:51 |
LjL | that's what i recall anyway! | 00:51 |
nixonix | you are apatized about all those lockdowns | 00:51 |
nixonix | is that a word? | 00:52 |
Brainstorm | New from r/WorldNews: worldnews: Brazil sets new single-day record with over 115,000 coronavirus cases → https://is.gd/rTrJBa | 00:52 |
LjL | nixonix, no, but i understood, so it's okay | 00:52 |
nixonix | apathized prob | 00:52 |
LjL | i am a bit tired of COVID in general but... that's probably everyone? | 00:53 |
nixonix | that one is a word, its found in urban dictionary | 00:53 |
LjL | i either find something to annoy me with vaccines, or some scary things like brains shrinking after COVID | 00:53 |
LjL | nixonix, it probably even works in greek where apathy originally comes from, the -ize ending is very greek | 00:53 |
nixonix | if you see palasso, ask him and tell me then | 00:54 |
nixonix | they used to read latin and greek. almost nobody read those anymore | 00:55 |
LjL | nixonix, if only the ancient greek wisdom had taught him that Libera > freenode! | 00:56 |
nixonix | it now looks like immunity from those common cold betacoronaviruses offer some protection vs sars2 | 01:07 |
nixonix | long time ago you wondered if we should try to catch them. i thought it wouldnt be a good idea, because there was no proof it would protect, they can be dangerous as eg OC43 is neuroinvasive, and there might even be harmfull interference | 01:08 |
nixonix | but now it looks like it would be protective, if its from OC43 or HK1. reduced symptoms in some study | 01:09 |
nixonix | but there was no link from those common cold alphacoronaviruses | 01:09 |
nixonix | i would link the paper, but i dont remember the title. i will when i find it some day | 01:10 |
nixonix | also rhinoviruses beat sars2 in competition about infecting cell culture. even when its inoculated a day later with rhino | 01:12 |
Brainstorm | New from r/WorldNews: worldnews: They relied on Chinese COVID vaccines. Now they’re battling outbreaks. → https://is.gd/ym28YP | 01:12 |
nixonix | so in theory, those that are exposed to sars2 infection, could be inoculated with some rhinovirus strain, if done quick enough | 01:13 |
de-facto | but why? | 01:14 |
de-facto | arent there more harmless ways to stimulate innate immunity? | 01:14 |
nixonix | works with flu too: | 01:15 |
nixonix | .title https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)63294-8/fulltext | 01:15 |
Brainstorm | nixonix: From www.clinicalmicrobiologyandinfection.com: Rhinoviruses delayed the circulation of the pandemic influenza A (H1N1) 2009 virus in France - Clinical Microbiology and Infection | 01:15 |
nixonix | no, its just that it somehow beats them in competition of infecting cells. rhino vs sars2 or rhino vs flu | 01:15 |
de-facto | hmm | 01:16 |
de-facto | what about rhinovirus infection already present in the nose hence having activated the local immune responses (hence causing a cold) | 01:17 |
nixonix | you might then be immune to sars2 while it lasts | 01:17 |
nixonix | but im not sure you could say its the activated immune response, because it beats sars2 even when inoculated day later | 01:18 |
nixonix | its something else | 01:18 |
de-facto | hence increased number of immune cells active in fighting against the rhinovirus in the mucus, so if few other viruses (influenza etc) come on that mucus they directly get attacked by the increased and alarmed number of immune cells already present there? | 01:18 |
de-facto | (complete speculation) | 01:18 |
nixonix | maybe its the cell signalling environment that rhino infection causes somehow, that is beneficial for rhinovirus but not for sars2 | 01:20 |
de-facto | afaik sars-cov-2 got some abilities to circumvent activation or even sabotage/suppress innate immune responses, so if something else activates them that even replicates faster maybe the innate immunity already is activated then hence killing off much more sars-cov-2 compared to if it was not activated by a cofactor like rhino | 01:21 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Epstein-Barr virus reactivation may be the cause of long COVID symptoms → https://is.gd/BE3UMc | 01:22 |
nixonix | idk. but thats interesting enough, ill try to find something about it some day | 01:24 |
nixonix | i dont have logs with this web client, but if somebody could find what i pasted about adenovirus and herpes, i think 2 days ago, please repaste | 01:26 |
nixonix | it seems almost everybody has EBV | 01:26 |
nixonix | damn, did i need to know that too? | 01:27 |
Brainstorm | New from ScienceNews: The benefits of COVID-19 mRNA vaccines outweigh the risk of rare heart inflammation: A CDC group says the benefits of the Pfizer and Moderna shots outweigh the risk of myocarditis and pericarditis in adolescents and young adults. → https://is.gd/5l71Aj | 01:32 |
LjL | nixonix, i'm afraid it's true, the vast majority of people have HSV, EBV, and HPV | 01:33 |
LjL | varies a bit depending on the locale | 01:34 |
LjL | you posted | 01:34 |
LjL | <nixonix> adenoviruses can infect the cells of the respiratory tract, while herpes viruses can infect those of the skin and nervous system. In most cases, this does not lead to the production of new virus particles, as the viruses are suppressed by the immune system | 01:34 |
LjL | <nixonix> However, adenoviruses and herpes viruses can cause persistent infections that the immune system is unable to completely suppress and that produce viral particles for years | 01:35 |
LjL | not sure if that's what you meant, i responded that herpes definitely stays in the nerve ganglia, while i didn't know adenovirus stayed around, and maybe they only do in immune compromised people or something | 01:35 |
nixonix | thanks. could you post the link also, that i think i pasted below those? i tried to find it. logs were so useful, maybe i sould start using real client again... | 01:41 |
nixonix | +h | 01:41 |
de-facto | nixonix, https://is.gd/xpld3l | 01:42 |
nixonix | thanks. i forgot there are those | 01:43 |
de-facto | 2021-06-22 | 01:43 |
nixonix | anyways, the easiest way is to just google a part of quote, which usually works | 01:45 |
nixonix | it was from this | 01:45 |
nixonix | .title https://www.sciencedaily.com/releases/2021/06/210621123733.htm | 01:45 |
Brainstorm | nixonix: From www.sciencedaily.com: Microscopy deep learning predicts viral infections -- ScienceDaily | 01:45 |
nixonix | makes you wonder if sars2 could stay around in some type of cells | 01:49 |
nixonix | like that they are not antigen expressing cells, and they are not activated to produce more virions for one or another reason | 01:50 |
nixonix | like nerve cells but perhaps in some other type of cells too | 01:50 |
LjL | nixonix, there was at least one paper on SARS2 staying inside gut cells | 02:01 |
LjL | if i'm lucky i might find it too | 02:01 |
LjL | nixonix, https://www.nature.com/articles/s41586-021-03207-w | 02:02 |
LjL | "Immunofluorescence and PCR analyses of intestinal biopsies obtained from asymptomatic individuals at 4 months after the onset of coronavirus disease 2019 (COVID-19) revealed the persistence of SARS-CoV-2 nucleic acids and immunoreactivity in the small bowel of 7 out of 14 individuals. We conclude that the memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence." | 02:02 |
nixonix | oh yeah, there was that. i havent really looked much at that, staying in intestines. which i need to fix | 02:07 |
-RSSBot[LjLmatrix- Recent Commits to links:master: Correct typo, add "gut" mainly to ease searching later ( https://github.com/ljl-covid/links/commit/64293f034b206bf7879b7d3d5d5f66393826b1ad ) | 02:08 | |
LjL | nixonix, i guess it kinda falls into the "did i really need to know that" category for me | 02:10 |
LjL | it's a delicate balance between the power of knowledge and the terror of knowledge | 02:10 |
nixonix | all the accumulating knowled will take things to better | 02:11 |
nixonix | id like to believe that. not sure if i succeed to do | 02:12 |
nixonix | ..ledge | 02:12 |
Brainstorm | New from https://covid19.specops.network : ljl-covid: Correct typo, add "gut" mainly to ease searching later → https://is.gd/UObDMb | 02:14 |
nixonix | that could help with somatic mutations in those plasma cells that stay decades in bone marrow. so maybe its a good thing | 02:15 |
nixonix | maybe it happens only in germinal center though | 02:17 |
nixonix | centers | 02:17 |
LjL | <de-facto> but why is myocarditis mainly after 2nd dose in young men? <nixonix> well, those side effects come mostly from 2nd dose too ← did you see the slightly pirated italian article i posted handwaving that further mRNA doses might not be a good idea because side effects may get worse and we may have to use protein subunits for the next vaccines? | 02:23 |
LjL | [19:37:57] <LjL> https://paste.ee/r/qu8h3/0 | 02:23 |
LjL | [19:38:25] <LjL> it basically says that there are indications that mRNA vaccines may not be sustenable in the long run (i.e. if we need a third, fourth, n+1th dose) | 02:23 |
LjL | [19:39:22] <LjL> because 1) we've already seen that the second dose cause more adverse reactions than the first, unlike other vaccines (like AZ), and so they extrapolate it to further doses, and 2) we also can extrapolate it to further doses because there are studies about it (unfortunately it doesn't mention which, but i assume earlier animal studies, it does mention a Margaret Liu as someone with this stance) | 02:23 |
LjL | [19:40:01] <LjL> the conclusion is that unless we manage to make sure with good trials that we *can* in fact continue using mRNA doses indefinitely, we may want to look at things like Novavax instead for the next doses | 02:23 |
LjL | Timvde, (sorry i hadn't seen your replies) i'd like to see the studies too, and it's annoying that this type of articles, even when they're written by supposed experts, don't _cite the damned studies_ just because they are in a general newspaper | 02:24 |
LjL | it "hints" at the existence of such studies | 02:24 |
LjL | not clear if repeated mRNA doses on animals, or what | 02:25 |
nixonix | if its the immune response, that could be adjusted for harm/benefit, and wouldnt anyways to be unnecessarily strong with later boosters. but adjusting meaning the cytokine profile, so that the immune response would be type that is better optimized to lessen the adverse effects | 02:26 |
nixonix | +have | 02:27 |
nixonix | anyways we already have some evidence that whole virus vaccines arent necessarily effective. for protein subunits, it looks like they can be. but i wouldnt count on that even most of them will be | 02:28 |
nixonix | novavax looks good, tho | 02:29 |
Brainstorm | New from BBC Health: (news): Long Covid: More than two million in England may be suffering, study suggests → https://is.gd/FO8xIv | 02:34 |
nixonix | but if theres inherent attribute of rna always causing more and more severe adverse reactions when repeted, then thats another thing. but is there. there was somebody who thought there is in that article | 02:39 |
nixonix | lets find out, another day | 02:39 |
Brainstorm | Updates for Fiji: +279 cases (now 2549), +2 deaths (now 11) since a day ago — France: +33 deaths (now 110926) since 21 hours ago — Canada: +609 cases (now 1.4 million), +14 deaths (now 26153) since 22 hours ago — Netherlands: +341 cases (now 1.7 million), +2 deaths (now 17871) since 21 hours ago | 02:40 |
Brainstorm | New from r/WorldNews: worldnews: China deleted early coronavirus data that could help explain pandemic origins, researcher finds → https://is.gd/19Yt57 | 03:15 |
Brainstorm | Updates for Rwanda: +964 cases (now 33260), +5 deaths (now 397) since a day ago — Cyprus: +167 cases (now 73999) since 22 hours ago — Eswatini: +44 cases (now 18898) since 23 hours ago | 03:29 |
bluesclues | the delta variant is going up in numbers | 03:48 |
bluesclues | wear your masks if you can please | 03:48 |
Raf[m] | Even if you're vaccinated? | 03:49 |
thanas | is pfizer vaccine effective against delta variant? | 03:52 |
bluesclues | thats a good question but i dont think so | 03:53 |
bluesclues | they need to find someway to come up with something | 03:53 |
bluesclues | its not over yet | 03:53 |
Brainstorm | New from Politico: How ambassadors took over the EU: Inside the ‘engine room’ that kept the European Union running through the pandemic — and gained power as a result. → https://is.gd/OjdJpv | 04:07 |
Brainstorm | Updates for Barbados: +7 cases (now 4052) since a day ago | 04:07 |
Brainstorm | Updates for Mauritania: +58 cases (now 20473), +1 deaths (now 483) since 22 hours ago | 04:32 |
LjL | thanas, bluesclues: it's been found to be effective. not *as* effective as with the alpha variant, but iirc 75% efficacy in a study | 04:50 |
LjL | which would put it up there with AstraZeneca on the original variant, so it's far from "not effective" | 04:50 |
LjL | actually no, the 75% was against B.1.351 (South African variant), although that's been the nastiest variant in terms of vaccine efficacy so far | 04:52 |
LjL | current British reports have both Pfizer and AZ as fairly efficacious at least against hospitalization with the Delta variant | 04:52 |
LjL | i really should update the links with some info about the Indian/Delta variant because there really is almost none :( | 04:53 |
LjL | https://www.gov.uk/government/news/vaccines-highly-effective-against-hospitalisation-from-delta-variant | 04:54 |
Brainstorm | Updates for Thailand: +4108 cases (now 232647), +31 deaths (now 1775) since 23 hours ago — United Kingdom: +14794 cases (now 4.7 million), +21 deaths (now 128154) since 23 hours ago — France: +39 deaths (now 110934) since 8 hours ago — Netherlands: +504 cases (now 1.7 million), +3 deaths (now 17872) since 23 hours ago | 05:09 |
Brainstorm | New from The Indian Express: World: With 1.15 lakh fresh cases, Brazil sets single-day record for coronavirus infections → https://is.gd/4vx8Ng | 05:29 |
Brainstorm | Updates for Mexico: +4963 cases (now 2.5 million), +342 deaths (now 231847) since 23 hours ago | 05:34 |
Brainstorm | New from r/WorldNews: worldnews: WHO finds problems at Russian vaccine plant; flags data, testing results → https://is.gd/Pi4V5U | 05:40 |
Brainstorm | New from The Indian Express (Health): Health: Post-Covid hair fall: Expert suggests ways to tackle the problem → https://is.gd/2rsKWa | 05:50 |
Brainstorm | New from The Indian Express: World: FDA to add warning about rare heart inflammation to Pfizer, Moderna vaccines → https://is.gd/O7cYpi | 06:01 |
Brainstorm | New from EurekAlert!: Better mental health supports for nurses needed, study finds: Working in the highly charged environment of COVID-19 has had a huge impact on the mental health of nurses, according to a new survey by researchers at the University of British Columbia and the Institute for Work & Health in Toronto.The findings, described recently in [... want %more?] → https://is.gd/W4ocyt | 06:32 |
Brainstorm | Updates for Guatemala: +2028 cases (now 284741), +60 deaths (now 8845) since a day ago — Belgium: +1026 cases (now 1.1 million), +5 deaths (now 25149) since 23 hours ago | 06:36 |
Brainstorm | New from EurekAlert!: COVID-19 monoclonal antibody therapy can reduce hospitalizations, healthcare system stress: Monoclonal antibodies work well in reducing COVID-19 related emergency department visits and hospitalizations when administered early to high-risk patients, a study by the University of South Florida Health (USF Health) and Tampa General [... want %more?] → https://is.gd/o4i1q9 | 06:52 |
Brainstorm | Updates for Rio Grande do Norte, Brazil: +40961 cases (now 1.5 million), +161 deaths (now 37406) since a day ago — England, United Kingdom: +12512 cases (now 4.1 million), +13 deaths (now 112598) since a day ago — Scotland, United Kingdom: +2969 cases (now 260711), +5 deaths (now 7701) since a day ago — Arequipa, Peru: +2703 cases (now 96869), +239 deaths (now 8543) since 5 days ago | 07:38 |
Brainstorm | Updates for India: +54069 cases (now 30.1 million), +1334 deaths (now 391552) since 22 hours ago | 08:40 |
Brainstorm | New from r/WorldNews: worldnews: U.S. Confirms Removal of Wuhan Virus Sequences From Database → https://is.gd/FGNFdc | 08:46 |
Brainstorm | New from r/Coronavirus: Daily Discussion Thread | June 24, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/nt65mP | 09:07 |
Brainstorm | Updates for Uzbekistan: +442 cases (now 107708), +1 deaths (now 723) since 22 hours ago | 09:30 |
Brainstorm | New from r/WorldNews: worldnews: Emperor Naruhito concerned Olympics may increase COVID-19 infections, official believes → https://is.gd/TSySAH | 10:09 |
Brainstorm | Updates for Delhi, India: +588 cases (now 1.4 million), +7 deaths (now 24940) since a day ago | 10:32 |
Brainstorm | New from The Indian Express (Health): Health: Over 2 million in England may have had long Covid, study finds → https://is.gd/b4h24c | 10:40 |
Brainstorm | New from StatNews: First Opinion: Opinion: Breaths, deaths, and missed breaks: How counting defined my days as a pandemic nurse → https://is.gd/CscXbV | 10:51 |
Brainstorm | New from The Indian Express: World: Sydney faces ‘scariest period’ in pandemic amid Delta outbreak → https://is.gd/kS4jDP | 11:01 |
Brainstorm | Updates for Russia: +20182 cases (now 5.4 million), +568 deaths (now 131463) since a day ago | 11:09 |
Brainstorm | Updates for Israel: +141 cases (now 840307) since 19 hours ago | 11:34 |
Brainstorm | New from BMJ: What I never consented to: I have a complex medical history and have experienced many tests, procedures, and surgeries. Over the years, I have consented to seemingly endless risks that came with these procedures, including... → https://is.gd/4L2EOA | 11:52 |
Brainstorm | New from BMJ: Correction: In the article ‘Interpreting a lateral flow SARS-CoV-2 antigen test’ (BMJ 2021;373:n1411 doi:10.1136/bmj.n1411) the authors state that “Evidence shows a strong correlation between Ct values and in... → https://is.gd/UC744J | 12:23 |
Brainstorm | New from The Indian Express (Health): Health: You’re vaccinated for COVID-19, and you just tested positive. Now what? → https://is.gd/PpRLkW | 13:35 |
Brainstorm | Updates for Fiji: +299 cases (now 2848) since 10 hours ago | 13:38 |
Brainstorm | New from ECDC: Data on testing for COVID-19 by week and country: The downloadable data file contains information about testing volume for COVID-19 by week and country. Each row contains the corresponding data for a country and a week. The file is updated weekly. You may use the data in line with ECDC’s copyright policy. → https://is.gd/1QzArh | 13:46 |
Brainstorm | New from The Atlantic: The New Best Vaccine for COVID-19: At the end of January, reports that yet another COVID-19 vaccine had succeeded in its clinical trials—this one offering about 70 percent protection—were front-page news in the United States, and occasioned push alerts on millions of phones. But when the Maryland-based biotech firm Novavax [... want %more?] → https://is.gd/zirxHH | 14:16 |
Brainstorm | Updates for Indonesia: +20574 cases (now 2.1 million), +355 deaths (now 55949) since a day ago — Bangladesh: +6058 cases (now 872935), +81 deaths (now 13868) since 22 hours ago — Switzerland: +2 deaths (now 10878) since 21 hours ago | 14:40 |
Brainstorm | New from ECDC: Data on hospital and ICU admission rates and current occupancy for COVID-19: The downloadable data files contain information about hospitalisation and Intensive Care Unit (ICU) admission rates and current occupancy for COVID-19 by date and country. Each row contains the corresponding data for a certain date (day or week) and per country. [... want %more?] → https://is.gd/PGEWAF | 14:47 |
-RSSBot[LjLmatrix- Feed: Comunicato stampa del Consiglio dei Ministri n. 25 ( https://www.governo.it/it/articolo/comunicato-stampa-del-consiglio-dei-ministri-n-25/17251 ) | 14:51 | |
Brainstorm | New from NIH Director's blog: New Metric Identifies Coronavirus Hotspots in Real Time: During the pandemic, it’s been critical to track in real time where the coronavirus is spreading at home and abroad. But it’s often hard for public health officials to know whether changes in the reported number of COVID-19 cases over time truly reflect the [... want %more?] → https://is.gd/kd9SOS | 15:08 |
Brainstorm | New from EMA: What's new: PIP: Opinion/decision on a Paediatric investigation plan (PIP): half-life extended bispecific T-cell engager (BiTE) antibody construct that binds to prostate-specific membrane antigen and cluster of differentiation 3, with a single chain fragment crystallizable moiety, decision type: , therapeutic area: , PIP number: P/0303/2020 → https://is.gd/RYk6y1 | 15:50 |
Brainstorm | Updates for Zambia: +3594 cases (now 140620), +61 deaths (now 1855) since a day ago | 16:07 |
Brainstorm | Updates for Nepal: +1577 cases (now 629431), +24 deaths (now 8918) since a day ago | 16:32 |
Krey[m] | Where is the CDC emergency meeting aAAaAaaAAaAAAaAAAAAAAAAAAA | 16:57 |
Brainstorm | New from In The Pipeline: Open the Floodgates: It should be obvious, given previous posts here, that I think that the FDA approval of Biogen’s aducanumab for Alzheimer’s was a mistake. It is a mistake for a whole list of reasons, and we’re about to see another one of those in action. Eli Lilly has been attacking Alzheimer’s for decades now, in [... want %more?] → https://is.gd/NlzBXJ | 17:03 |
Brainstorm | New from LitCovid: (news): COVID 19 pandemic: Economics and future of oral care. → https://is.gd/q8xuxP | 17:23 |
Brainstorm | Updates for Germany: +649 cases (now 3.7 million), +43 deaths (now 90916) since 21 hours ago — Canada: +12 deaths (now 26155) since 21 hours ago | 17:34 |
Brainstorm | New from ClinicalTrials.gov: (news): Study of Arrhythmia and ECG Abnormalities in Patients With COVID-19 → https://is.gd/xqmVkN | 17:44 |
Brainstorm | Updates for United Kingdom: +16702 cases (now 4.7 million) since 23 hours ago | 17:59 |
Brainstorm | New from The Indian Express (Health): Health: 72-year-old British man recovers after testing Covid positive for 10 months → https://is.gd/unyviK | 18:15 |
chitCat | Krey[m]: emergency? | 18:16 |
Krey[m] | yesh about the heart inflammation in <30 | 18:16 |
Krey[m] | chitCat: ^ | 18:16 |
chitCat | Krey[m]: missed it, what makes it an emergency | 18:21 |
Krey[m] | afaik it's associated with a report from israel with 300 people having heart inflammation after Pfizer/biontech vaccine | 18:21 |
* Krey[m] cancelled his vaccine bcs of it | 18:21 | |
Krey[m] | chitCat: you know it's that kind of "emergency" that can wait for the next week 💢 | 18:25 |
chitCat | you do then, seemed concerned | 18:26 |
Krey[m] | ah 800 cases now? | 18:28 |
Krey[m] | and the meeting was moved or something again? | 18:32 |
Krey[m] | grr the incompetence in this! | 18:32 |
Arsanerit | Approximately 62½ hours until I get my second dose of Comirnaty® (developed and produced by BioNTech). | 18:35 |
Juerd | Hi Arsanerit | 18:36 |
Brainstorm | Updates for Myanmar: +787 cases (now 150714), +6 deaths (now 3275) since 20 hours ago | 18:37 |
Juerd | Arsanerit: Isn't it developed by Biontech, produced by Pfizer? | 18:37 |
Arsanerit | Hi Juerd. Long time no "see". No, the vaccines distributed here in Germany are produced by BioNTech themselves, mostly at their site in Marburg. | 18:39 |
Juerd | Ah | 18:40 |
Arsanerit | Juerd: How are you? | 18:40 |
Juerd | Arsanerit: This is a publicly logged channel so I won't go into any personal things :) | 18:40 |
Arsanerit | Juerd: Fair enough. | 18:40 |
chitCat | Krey[m]: chemotherapy also is known to have risks, if thats not a bad example | 18:48 |
Krey[m] | chitCat: yes, but the risks are known with a risk factors | 18:51 |
Brainstorm | Updates for Portugal: +1556 cases (now 869879), +2 deaths (now 17079) since a day ago | 19:01 |
LjL | did i hear right 16k new cases in the UK today? | 19:36 |
LjL | %cases UK | 19:36 |
Brainstorm | LjL: In United Kingdom, there have been 4.7 million confirmed cases (7.1% of the population) and 128159 deaths (2.7% of cases) as of an hour ago. 206.0 million tests were performed (2.3% positive). See https://offloop.net/covid19/?default=United%20Kingdom for time series data. | 19:36 |
Brainstorm | New from Scientific American: Health: Gut Reactions: Microbes in the Digestive Tract Influence COVID Severity → https://is.gd/TwvUgx | 19:38 |
Brainstorm | Updates for Germany: +673 cases (now 3.7 million) since 22 hours ago | 19:39 |
LjL | what is up with the British numbers, 17k today, 16k yesterday, a sudden jump | 19:41 |
LjL | also is there anywhere we can clearly see graphs and percentages of how many of the cases are vaccinated, and with which vaccine? | 19:42 |
LjL | i know there are government reports on vaccination efficacy on hospitalizations, but that's just one thing | 19:42 |
Brainstorm | New from StatNews: Pharma: STAT+: Pfizer halts global distribution of smoking cessation pill as it tests for potential carcinogens → https://is.gd/JgDvVL | 19:48 |
Brainstorm | New from Reddit (test): nCoV: Indian "Delta" mutated strain, 60% more dangerous than UK "Alpha" (Samoud) | 24JUN21 → https://is.gd/X09xOa | 20:40 |
Brainstorm | Updates for Israel: +123 cases (now 840430) since 9 hours ago | 20:41 |
francis | LjL: apparently the spike is due to surge testing in scotland which has also had record case numbers today and yesterday | 20:42 |
francis | not entirely convinced it's all scotland's fault tho | 20:42 |
Brainstorm | New from Scientific American: Nutrition, Immunity and a Global Pandemic: The COVID-19 pandemic has focused attention on the importance of having a well-functioning immune system. -- Read more on ScientificAmerican.com → https://is.gd/ULxkF1 | 20:51 |
de-facto | just made a fit of both B.1.1.7 and B.1.617.2 in Germany, R(B.1.1.7) ~ 0.9 and R(B.1.617.2) ~ 1.3 meaning +44.4% and the sum of both exponentials got a mimimum at 2021-07-04 | 21:01 |
de-facto | meaning B.1.617.2 will lead to raising incidence from 4th of July in Germany if conditions stay unchanged | 21:01 |
de-facto | so i assume begin to mid of July is a realistic estimation for that unfortunately | 21:02 |
Brainstorm | New from CIDRAP: COVID-19 Scan for Jun 24, 2021: COVID vaccine and household risk Skin reactions and COVID vaccines → https://is.gd/xji6U2 | 21:21 |
de-facto | .title https://imgur.com/a/ToWETLU https://i.imgur.com/7nEfEq9.png src tab 5 in https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/DESH/Bericht_VOC_2021-06-23.pdf?__blob=publicationFile | 21:28 |
Brainstorm | de-facto: From imgur.com: COVID Germany: Evolution of PANGO Lineages B.1.1.7 vs B.1.617.2 - Album on Imgur | 21:28 |
Brainstorm | Updates for Cuba: +1880 cases (now 174789), +16 deaths (now 1209) since a day ago — Spain: +4507 cases (now 3.8 million), +18 deaths (now 80766) since a day ago — France: +18 deaths (now 110944) since 18 hours ago | 21:31 |
de-facto | 50/50 incidence crossover point would be 2021-07-13 | 21:59 |
Arsanerit | that's the way I was considering to depart on vacation | 22:09 |
Arsanerit | *the day | 22:10 |
LjL | de-facto, what is the percentage of Delta now? | 22:21 |
de-facto | i think something like 15.1% | 22:22 |
de-facto | yeah week 23 in another table | 22:24 |
de-facto | the fit i made were lab data because they provide absolute weekly numbers, but that 15.1% is the RKI data themselves afaik | 22:25 |
de-facto | so there might be a different delay involved | 22:25 |
de-facto | hence i said begin to mid of July | 22:25 |
LjL | francis, yeah i've heard that from others too, but excuse my ignorance, what is even surge testing to begin with? | 22:32 |
Brainstorm | Updates for Mozambique: +441 cases (now 73652), +6 deaths (now 863) since a day ago — Jersey: +22 cases (now 3361) since a day ago | 22:33 |
Brainstorm | New from WebMD: Lost Sense of Smell Returns for Almost All After COVID: A new study finds a year on, nearly all patients who lost their sense of smell after a bout of COVID-19 did regain that ability. → https://is.gd/1BQ5Sr | 22:33 |
qunzhong_luxian | What I find to be interesting is that the loss of smell has not been as prominent of a symptom of the delta variant. In the UK it dropped out of the top 10 symptoms. https://www.bbc.com/news/health-57467051 | 22:35 |
francis | LjL: surge testing basically means that, whenever a cluster of infections is detected, people in that area (post code, borough, village etc) are all encouraged to get a test so they can self-isolate if they're positive | 22:35 |
LjL | francis, makes sense, but they must have found some *big* clusters to justify the surge... although someone was telling me it's pretty predictably exponential based on https://pbs.twimg.com/media/E4qAK7gXMAYP_y_.png but this doesn't make it very clear which date it reaches | 22:40 |
LjL | qunzhong_luxian, that could be good news in a way (except apparently Delta results in more hospitalizations) because there was a recent paper floating around showing loss of brain mass in COVID patients, in particular of the areas of the brain linked to smell and taste, which is pretty creepy if you ask me, so any hint that the new variant may cause *less* of that is good news | 22:41 |
LjL | on the other hand it was a very recognizable and somewhat unique symptom, while that BBC article says that in general, aside from the severe cases, the variant may spread more because people feel less sick... | 22:41 |
qunzhong_luxian | Ooh, that actually is a pretty nice angle that I had not thought of before, but yeah I do share the concerns from the BBC article with the lack of distinctive symptom making people less likely to quarantine and such if it just feels like a head cold. | 22:42 |
de-facto | that looks pretty much like the features of the curve i extrapolated for Germany too LjL | 22:42 |
francis | LjL: it depends, surge testing has been going on here for quite a while now | 22:52 |
francis | the gov't are more than willing to chuck money/tests at an area to clamp down on the case numbers so they don't have to keep delaying The Grand Unlocking after promising it'll really happen on date X/Y | 22:52 |
francis | that graph looks eerily familiar, too :( | 22:53 |
LjL | francis, i don't disagree with that approach, even though i might disagree with the reason behind it... | 22:53 |
francis | aye | 22:53 |
francis | bad to reword once or twice in this exchange so I don't get, er, political ;D | 22:53 |
francis | had to, even | 22:54 |
Brainstorm | New from CIDRAP: Delta COVID variant fuels global surges, complicates reopenings: Lisa Schnirring | News Editor | CIDRAP News Jun 24, 2021 Twelve African nations battle surges, and Brazil records a daily high in COVID-19 cases. → https://is.gd/Fs2KGC | 23:05 |
de-facto | .title https://www.medrxiv.org/content/10.1101/2021.06.10.21258647v1.full-text | 23:10 |
Brainstorm | de-facto: From www.medrxiv.org: Seasonal variation in SARS-CoV-2 transmission in temperate climates | medRxiv | 23:10 |
de-facto | "Building on two state-of-the-art observational models and datasets, we adapt a fully Bayesian method for estimating the association between seasonality and transmission in 143 temperate European regions. We find strong seasonal patterns, consistent with a reduction in the time-variable Rt of 42.1% (95% CI: 24.7% – 53.4%) from the peak of winter to the peak of summer." | 23:17 |
Brainstorm | Updates for Canada: +777 cases (now 1.4 million), +18 deaths (now 26170) since 23 hours ago | 23:41 |
LjL | de-facto, strong, but then just one variant compared to the other adds 0.7 to the R... | 23:42 |
LjL | my pessimism just says that's a good reason to be wary of next winter even if it seems now the vaccines are "taking care of it" (the vaccines, or the summer?) | 23:43 |
de-facto | so with minimum of seasonality factor in July it will be both, Delta and seasonality that will cause increase | 23:43 |
LjL | de-facto, what do you mean? Delta will cause increase, but July is at *minimum* | 23:45 |
de-facto | delta is approximately +45% over alpha and if that above is correct its another +42% till winter at least, meaning almost double the reproduction we have right now with alpha in the summer | 23:45 |
de-facto | two distinct effects, contribution from generic seasonality and the other from delta taking over alpha | 23:45 |
LjL | yes but the seasonality makes it *lower* | 23:46 |
LjL | so i don't understand why you say they will both case an increase | 23:46 |
LjL | July 1 is the minimum | 23:46 |
de-facto | yes so from july 1st it will start to increase | 23:46 |
de-facto | from minimum to maximum in the winter | 23:46 |
LjL | yeah okay but the Delta effect will probably happen much faster, while seasonality is still at less than 1 multiplier | 23:47 |
de-facto | yes of course | 23:48 |
de-facto | i just meant we will have contributions from both in the same direction, more reproduction | 23:48 |
de-facto | Delta already got R~1.3 in both UK and Germany right now | 23:49 |
Krey[m] | SINCE WHEN ARE THERE TONADOS IN CZECHIA | 23:53 |
LjL | de-facto, i was shown that in the UK, people 20-24 are now leading the infections, but children 5-9 are the ones most on the rise | 23:53 |
Krey[m] | aaAAAaAaaAAaAAAA | 23:53 |
LjL | Krey[m], since always, tornadoes happen Europe, not as often as in the Tornadoey places in the US, but they still happen | 23:53 |
Krey[m] | never in 40 years | 23:53 |
Krey[m] | and strongest recorded | 23:54 |
Krey[m] | (in czechia) | 23:54 |
LjL | Tornadoes in Czech Republic 9 June 2004 Czech Republic 2 No known injuries or fatalities There were 2 Tornadoes in Czech Republic, first was probably F1, second was F3. First appeared at Seninka at 14:15 UTC, The second and stronger, appeared only 15 minutes after the first one and it was at Litovel. | 23:54 |
LjL | but okay, they weren't a strong as this one, probalby | 23:55 |
Krey[m] | source? | 23:55 |
LjL | https://en.wikipedia.org/wiki/List_of_European_tornadoes_and_tornado_outbreaks | 23:55 |
LjL | just ctrl+f czech | 23:55 |
Krey[m] | dunno about it.. we have strong storms that people call tornados very often.. not 100+ injured 8 killed, buildings destroyed and cars flying in the air kind of tornado | 23:56 |
Krey[m] | and my hugging garden is hugged 💢 | 23:57 |
Krey[m] | *at least 8 dead | 23:57 |
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