| nixonix | .title https://www.medicaldevice-network.com/news/memed-ce-mark-covid-19-severity/ | 00:00 |
|---|---|---|
| Brainstorm | nixonix: From www.medicaldevice-network.com: MeMed obtains CE mark for MeMed COVID-19 Severity | 00:00 |
| nixonix | funny that not single interleukins used | 00:00 |
| de-facto | i think there also were some machine learning approaches iirc | 00:00 |
| nixonix | yeah, those were in the plan last summer already, like one finnish product i linked here back then | 00:01 |
| de-facto | like neuronal network, feed in all available parameters, give it some reward metric for predicting severity and let its prediction precision evolve with many datasets | 00:02 |
| Brainstorm | Updates for Aruba: +61 cases (now 11521) since 20 hours ago | 00:06 |
| nixonix | i dont know about that diabetes thing, i think its rare. no ace2 in those beta cells. there is tmprss and nlp-1 but not that much | 00:21 |
| nixonix | an article said tmprss, not tmprss2 - a typo or something close enough, idk | 00:21 |
| nixonix | .title https://www.nature.com/articles/s42255-020-00339-7 | 00:22 |
| Brainstorm | nixonix: From www.nature.com: Can COVID-19 cause diabetes? | Nature Metabolism | 00:22 |
| de-facto | diabetes is one of the major risk factors for severe progressions | 00:22 |
| nixonix | but it could reactivate dormant viruses like vsv | 00:26 |
| nixonix | (i dont know why i added that, its an another subject. i guess to balance out something positive with some negative, that hasnt been mentioned much) | 00:27 |
| nixonix | some of the long covid symptoms may actually be due to dormant sars2 reactivation | 00:28 |
| nixonix | if it hides in some type of cells, where its deactivated their internal immune response | 00:29 |
| de-facto | we definitely need to know more about breakthrough, it will become more and more relevant to majorities | 00:33 |
| nixonix | https://twitter.com/Birdyword/status/1418592323831750664 | 00:34 |
| nixonix | if uk had nearly reached herd immunity threshold for kent variant (vaccinations and infections, considering spring and measures affecting), and then the same happened that fast with indian variant at all the regions | 00:35 |
| nixonix | that would mean its R_0 must be really high | 00:36 |
| nixonix | to spread that fast at all the regions | 00:36 |
| nixonix | even with freedom day and all happening | 00:37 |
| nixonix | and the same in holland (although they reinstated some measures) | 00:38 |
| nixonix | but i expected that to happen quite soon in uk anyway. since the difference for the threshold isnt that big, even if the differences with R0 are | 00:39 |
| nixonix | like 75-80% -> 85-90% or so. and vaccinations progressing all the time | 00:40 |
| de-facto | from my fits for Germany it was like Rt(Delta) ~ 1.45 Rt(Delta) iirc | 00:40 |
| nixonix | 1.45*kent? i think its more, even more than 1.6 | 00:41 |
| de-facto | .title https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19latestinsights/antibodies | 00:41 |
| Brainstorm | de-facto: From www.ons.gov.uk: Coronavirus (COVID-19) latest insights - Office for National Statistics | 00:41 |
| nixonix | yeah i pasted that earlier | 00:42 |
| de-facto | correction: from my fits for Germany it was like Rt(Delta) ~ 1.45 Rt(Alpha) iirc | 00:43 |
| de-facto | yeah kent | 00:43 |
| nixonix | or this, but the same info https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveyantibodyandvaccinationdatafortheuk/21july2021 | 00:44 |
| nixonix | yeah, i figured that | 00:44 |
| nixonix | so when is germany following denmark, france, italy with vaccine passports for bars and events? | 00:48 |
| nixonix | theres talk about those now in finland. the problem is (exp that some politicians oppose), that they would want recent negative test accepted too, and you need to go to private doctor for them, costing 100-200 | 00:49 |
| nixonix | recent poll, 63% support, 24% oppose, the rest cant say | 00:49 |
| nixonix | poll for vaccinations, only 6% said they want be getting vaccinations. the share of not sure was something like 15% or so, i think | 00:50 |
| de-facto | imho vaccine passports are a very bad idea, because then vaccinated dont get tested, despite the knowledge there are (asymptomatic?) breakthrough infections | 00:51 |
| de-facto | as you said, for preventing transmission we probably need nasal spray vaccines inducing IgA | 00:51 |
| de-facto | yet, for motivating vaccinations, hence preventing severe progressions and reducing load on healthcare system, those vaccine passports may be good | 00:52 |
| de-facto | so there are always two sides to any measure | 00:52 |
| dTal | de-facto, there are many many consequences of vaccine passports though | 00:55 |
| dTal | for example they might motivate people to get vaccinated | 00:55 |
| de-facto | yeah of course | 00:55 |
| dTal | they also allow gatherings of only vaccinated people, which are much safer even if one of the attendees has an asymptomatic breakthrough case | 00:56 |
| LjL | de-facto, actually i heard that Germany is going to keep requiring test from inbound travellers even if they're vaccinated | 00:56 |
| de-facto | that would be really good, afaik they discuss tests for non-vaccinated currently | 00:57 |
| de-facto | i really do hope they just would go ahead a test fully vaccinated too | 00:57 |
| LjL | well i don't know, they said it on Italian tv, they may be wrong | 00:57 |
| de-facto | then they could know how many breakthrough we have, and sequence those | 00:57 |
| dTal | wow it reallly does look as if UK's delta wave has burned out | 00:58 |
| de-facto | imho that approach would be much more sane, test everyone, then monitor for changes instead of assuming things we simply dont know yet (evolution of breakthrough rates) | 00:58 |
| de-facto | dTal, that would be really good news if it ran out of fuel, yet i remain a bit skeptic still | 00:59 |
| nixonix | not representative sample, tho, because 86% said they already had at least 1st dose (its prob around 80% now for over 18, 1st dose prevalence here). 6% were never-vaxxers, 6% more will take, and 2% not sure. those that answered the poll | 01:01 |
| nixonix | those antivaxers will be marginalized... i wonder if they will radicalize | 01:06 |
| dTal | you speak as if they aren't already | 01:06 |
| nixonix | you are ahead there in uk | 01:07 |
| dTal | I do think it's a mistake to use the category "antivaxer" | 01:07 |
| dTal | covid vaccine resistance is a seperate phenomenon from the classic crystal homeopathy soccer mom karen crowd antivaxer | 01:08 |
| nixonix | yeah many of them are just worried of the rare side effects. but i was thinking about those antivax ramblers, that i just today read on some forum | 01:08 |
| dTal | sorry for the stereotype | 01:08 |
| dTal | but hopefully you understand | 01:08 |
| de-facto | yeah looks like travel returnees test unless vaccinated, already upsets me that they ignore breakthrough completely, i dont know why | 01:08 |
| nixonix | with their "evidence", really important doctors saying this and that, accumulating in ovaries and what not | 01:08 |
| dTal | magical thinking and convenience de-facto | 01:09 |
| de-facto | btw am officially fully vaccinated since yesterday, still wearing mask and continue exactly as before | 01:10 |
| nixonix | i hope they keep having protests the whole 5 years while waiting for those long term side effects to appear | 01:10 |
| de-facto | the difference is that tests for air passengers already is mandatory, now they want to make it mandatory for normal car driving passengers on "border" too | 01:11 |
| nixonix | i wonder how they will do that | 01:12 |
| de-facto | i am not sure, but that seems to be what they discuss | 01:12 |
| nixonix | and eu doesnt like it, restricting free movement | 01:12 |
| nixonix | they used to nag about our stricter restrictions since the last summer | 01:13 |
| nixonix | border restrictions | 01:13 |
| de-facto | but a test makes a lot of sense | 01:14 |
| de-facto | requiring test cert, then controlling minority of car drivers with police | 01:15 |
| nixonix | theres quite a bit those type of people, silver water drinkers and like, not going to get vaccinated in europe. maybe not that many in uk | 01:15 |
| nixonix | (not sure if drinking silver water is a thing outside of finland) | 01:16 |
| de-facto | never heard that before | 01:16 |
| nixonix | it cures things, i think | 01:17 |
| de-facto | RKI wants to remain at incidence values for indicating epidemic status evolution | 01:18 |
| nixonix | some feller was in some eastern european country, possibly hungary. he said men were manly guys who didnt believe in rona severity or vax, and women were silver water drinkers and stuff | 01:19 |
| nixonix | so didnt look very promising vaccine coverage | 01:19 |
| nixonix | vax curve in estonia was in downward slope already. and they got extra doses due to high case numbers and complaining to eu (austria didnt participate in sharing) | 01:21 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.07.26.21261130v1 | 01:26 |
| Brainstorm | nixonix: From www.medrxiv.org: Vaccine effectiveness when combining the ChAdOx1 vaccine as the first dose with an mRNA COVID-19 vaccine as the second dose | medRxiv | 01:26 |
| de-facto | nice | 01:31 |
| nixonix | .title https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00127-7/fulltext | 01:39 |
| Brainstorm | nixonix: From www.thelancet.com: Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel - The Lancet Regional Health – Europe | 01:39 |
| nixonix | semi-recent mrna vaccination, VE against symptomatic infection with indian variant close to 90%, PCR positivity around 80% (not sure of source for this), and if getting infected, then the likelihood to infect onwards reduced - but how but how much with indian variant. around half perhaps | 01:44 |
| nixonix | *but by how much | 01:45 |
| nixonix | tired | 01:45 |
| nixonix | so double vaccinated, if its somewhat recent, is a better preventive measure than those rapid tests, for access to bars and events | 01:48 |
| nixonix | and it forces other than hardcore antivaxes to take a shot | 01:49 |
| nixonix | ..vaxers | 01:49 |
| nixonix | https://twitter.com/MDaware/status/1420119708536295426 | 01:51 |
| nixonix | .title https://www.bmj.com/content/374/bmj.n1648 | 01:54 |
| Brainstorm | nixonix: From www.bmj.com: Long covid—mechanisms, risk factors, and management | The BMJ | 01:54 |
| nixonix | .title https://www.pharmaceutical-technology.com/features/developing-an-oral-covid-19-vaccine/ | 02:06 |
| Brainstorm | nixonix: From www.pharmaceutical-technology.com: Developing an oral Covid-19 vaccine | 02:06 |
| Brainstorm | New from NPR: The FDA Extends The Expiration Date On Johnson & Johnson's COVID Vaccine To 6 Months: The change gives health workers more time to use millions of doses, rather than discarding them. Expiration dates are based on data from drugmakers on how long the shots stay at the right strength. → https://is.gd/zfYkAX | 02:14 |
| Elw3 | Say what is the preferable vaccine to get right now? | 02:18 |
| Raf[m] | <Elw3 "Say what is the preferable vacci"> I would say probably Moderna, or Pfizer close second | 02:23 |
| Raf[m] | My 2 cents. Not medical advice | 02:23 |
| Raf[m] | mRNA seems more reliable and safer than say, Jannsen or AstraZeneca | 02:23 |
| mpsaro[m] | Completely false information | 02:26 |
| Elw3 | It is at least quoted for less side effects, but then again its covered in nano particles and there are no long term studies on that. Suspectely they are carcinogenic. | 02:26 |
| mpsaro[m] | Moderna, pfizer, AZ and J&J are all poison | 02:27 |
| mpsaro[m] | https://rumble.com/vkgdq7-deadly-shots-former-pfizer-employee-confirms-poison-in-covid-vaccine.html | 02:27 |
| LjL | says the one who linked to random "5G uses frequencies made for bioweapons" nonsense | 02:27 |
| Elw3 | Yesyes, so is oxigen, breathing lets you burn alive very slowly. But i want to know which is least poisonous. | 02:28 |
| LjL-Matrix | Elw3: there are multiple possible angles to ask that question from, though. now you say "which is the least poisonous"... now I really don't feel as confident as Raf yet in saying the mRNA side effects are more benign / rarer than the adenoviral ones (in both cases they're rare, but the Pfizer myocarditis surfaced later and may be hiding in more cases, although I bet it's usually much less devastating than the AZ thing), but to me, the first | 02:31 |
| LjL-Matrix | metric would be "which is the one that fights COVID best" | 02:31 |
| Raf[m] | Pfizer myocarditis.. is that in adolescents? I think I heard something about that | 02:33 |
| LjL | but ultimately if *i* were to choose which vaccine to get, on a wholly personal assessment, which may include irrational as well as rational factors probably, i would also get either Moderna or Pfizer, which no big preference towards either (Moderna is said to have slightly more annoying side effects, but on the other hand, Pfizer is not yet trialling a variant vaccine, while Moderna already is, so i'd hope to get a Moderna booster for Delta sooner) | 02:33 |
| LjL | Raf[m], not just adolescents, it has occurred in people under 30 or so, but of course in adolescents it may be considered a more serious issue in a risk/benefit analysis | 02:34 |
| LjL | Raf[m], i think report of it started to come from Israel originally, but then the FDA caught up | 02:34 |
| Raf[m] | Interesting | 02:34 |
| Brainstorm | Updates for Vietnam: +6559 cases (now 120819), +106 deaths (now 630) since 23 hours ago — Netherlands: +3793 cases (now 1.9 million), +5 deaths (now 17951) since 23 hours ago — Germany: +4396 cases (now 3.8 million), +69 deaths (now 92106) since 14 hours ago — Canada: +548 cases (now 1.4 million) since 23 hours ago | 02:35 |
| Elw3 | I thought the numbers of these _side effects_ where in the normal distributation of these problems to begin with, in other words the number isnt statistically detectable. | 02:38 |
| LjL | Elw3, both problems (AZ blood clotting and Pfizer myocarditis) have been causally attributed to the vaccines. AZ has been phased out in most of the EU for people younger than 60 or so, partly due to that (although you could argue there are also commercial/political reasons, plus that if people are scared of it, even if the effect is very rare, might as well give up trying) | 02:40 |
| LjL | Elw3, you may have heard that the cases of blood clotting are well within the normal distribution of blood clotting, and that's true, but the thing AZ causes is a very specific situation that is not just *any* type of blood clotting | 02:40 |
| Elw3 | Sounded political to me. | 02:40 |
| LjL | anyway i'm not here to say that AZ is particularly dangerous. i don't like AZ but that's mainly because the company messed up quite a few things, and the vaccine simply isn't all that efficacious | 02:41 |
| LjL | if AZ were more efficacious than Pfizer/Moderna, i'd take AZ, regardless of the small thrombosis risk | 02:41 |
| LjL | (i mean, still in the hypothetical scenario where i can choose, since i really can't :P) | 02:42 |
| Elw3 | If that all is the case it might be that you cant even select AZ as an option to begin with making the whole question pointless. | 02:42 |
| LjL | i don't have "options" | 02:43 |
| LjL | i can either take what i'm offered, or refuse the vaccine and end up at the bottom of the list | 02:43 |
| LjL | so yes, it *is* pointless for me specifically | 02:43 |
| LjL | but you asked the question :P | 02:43 |
| Elw3 | You are still waiting for a shot? | 02:44 |
| LjL | no, i actually got Pfizer, which is nice since that's what i hoped for | 02:44 |
| Elw3 | Here in germany ppl are apparently not going and the Vaccine piles up. | 02:44 |
| LjL | but i'm saying it's how it works here and how it worked for me | 02:44 |
| LjL | yes, it happened in some regions here with AZ as well... | 02:44 |
| LjL | not sure if you're talking about AZ or other vaccines are piling up too? | 02:45 |
| LjL | right now i'm hearing that the green pass becoming mandatory for a few things is boosting vaccine bookings up again | 02:45 |
| Elw3 | That i dont know. But the radio is full of "the vacc is here, but we miss the people!" | 02:45 |
| Elw3 | Figured i can take a shot without that much hassle now so i look into it. | 02:46 |
| LjL | i'm not too surprised... it's August, people want to be on holidays, meanwhile the majority of the people who wanted the vaccines have gotten the vaccine, so many of those who are left are necessarily harder to reach, either because they are vaccine-hesitant or for other reasons | 02:46 |
| LjL | (yes, i know it's still technically July) | 02:46 |
| LjL | for me now the biggest concern is that none of the vaccines are effective *enough* against Delta | 02:47 |
| LjL | so really the vaccine *i* would choose, ideally, is whatever Moderna is coming up with that has sequences for variants (not directly Delta yet i think, but it should be more efficacious on Delta as well anyway, and they also talked about a "one-shot" multivalent vaccine) | 02:48 |
| LjL | i'd arguably prefer to choose it after it's gotten past a phase 3 trial, but again, pointless, since it's not like i *can* get it until after it has :P | 02:49 |
| LjL | Germany has also been doing mixed AZ+mRNA shots, which according to some (maybe slightly quick and dirty?) studies is actually the combination that produces the most antibodies | 02:50 |
| LjL | but if adverse effects are a concern for you, well, you're logically exposing yourself to the ones elicited by both, plus potentially some elicited by the combination, although the study only found more of the annoying-but-benign side effects | 02:51 |
| LjL | myself, while i recognize these vaccines have been tested for a relatively brief period compared to any other vaccine i've had, i'm *overwhelmingly* more concerned about side-effects of COVID (including long-term ones) than with the ones from the vaccine | 02:52 |
| Elw3 | I think its too late for a second shot anyway. I plan to get an updated delta version next anyway. | 02:53 |
| LjL | i'm not too optimistic on delta-specific versions coming very soon :( | 02:55 |
| LjL | but hey i'm generally not optimistic on anything so you may ignore me | 02:55 |
| Elw3 | Eh, i hate optimists. | 02:57 |
| LjL | Elw3, if you get an mRNA shot now-ish, you're likely to get the second one end of august / start of september, and there's no way an updated vaccine will be already rolled out in the EU by then | 02:57 |
| de-facto | .title https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-provide-update-booster-program-light-delta | 02:57 |
| Brainstorm | de-facto: From investors.biontech.de: Pfizer and BioNTech Provide Update on Booster Program in Light of the Delta-Variant | BioNTech | 02:57 |
| de-facto | "While Pfizer and BioNTech believe a third dose of BNT162b2 has the potential to preserve the highest levels of protective efficacy against all currently tested variants including Delta, the companies are remaining vigilant and are developing an updated version of the Pfizer-BioNTech COVID-19 vaccine that targets the full spike protein of the Delta variant." | 02:58 |
| de-facto | "The first batch of the mRNA for the trial has already been manufactured at BioNTech’s facility in Mainz, Germany. The Companies anticipate the clinical studies to begin in August, subject to regulatory approvals." | 02:58 |
| LjL | "While Pfizer and BioNTech believe a third dose of BNT162b2 is cheaper for us to make and so we'd make more money, the FDA and CDC gave us the finger, so, okay, we're going to make a variant vaccine, pffffft" | 02:58 |
| de-facto | well they do both i guess | 02:59 |
| LjL | sure they had both cards up their sleeve, but they were certainly hoping to get an EUA for a third regular shot | 03:00 |
| de-facto | probably would be faster available | 03:00 |
| de-facto | with the signature update they need to run clinical studies again | 03:00 |
| LjL | de-facto, do you know the date of that press release? i might be blind but i don't see a date on the page, and i don't see a corresponding press release by Pfizer | 03:01 |
| de-facto | 8 July 2021 | 03:02 |
| de-facto | https://investors.biontech.de/press-releases | 03:02 |
| LjL | thanks | 03:04 |
| LjL | i'm adding their RSS feed to the bot too, will see if Moderna and AZ have one too | 03:04 |
| LjL | looks like Moderna isn't modern enough to have an RSS feed for their press releases :< | 03:05 |
| LjL | and neither does AZ, uff | 03:06 |
| LjL | Novavax is best, they have a COVID-specific RSS feed | 03:08 |
| de-facto | yeah could not find feeds for them either | 03:08 |
| de-facto | AZ and Moderna i mean | 03:09 |
| LjL | BioNTech and Pfizer both have one, which is going to be redundant, but oh well | 03:09 |
| LjL | mass bot restart time | 03:09 |
| de-facto | yeah in doubt go with BioNTech since they develop it | 03:10 |
| de-facto | but i guess they are copies of each others press releases more or less | 03:10 |
| LjL | Raf[m], just because i'm noticing it in this press release, BNT itself says "Reports of adverse events following use of the Pfizer-BioNTech COVID-19 Vaccine under EUA suggest increased risks of myocarditis and pericarditis, particularly following the second dose. The decision to administer the Pfizer-BioNTech COVID-19 Vaccine to an individual with a history of myocarditis or pericarditis should take into account the individual’s clinical circumstances." | 03:16 |
| Raf[m] | that makes sense | 03:16 |
| LjL | but despite not wanting to give medical advice, i think de-facto's idea of *not* exercising (at least not strenuously) after getting the shot for a few days can't go wrong | 03:17 |
| LjL | (if you're under 30 or so at least) | 03:17 |
| LjL | myocarditis can resolve on its own if it's mild, but can also give you a heart attack if you run the marathon | 03:17 |
| Raf[m] | i agree | 03:17 |
| LjL | and the for what is worth, statistics are statistics but then there are individual: here are the common side effects they list, "In clinical studies, adverse reactions in participants 16 years of age and older included pain at the injection site (84.1%), fatigue (62.9%), headache (55.1%), muscle pain (38.3%), chills (31.9%), joint pain (23.6%), fever (14.2%), injection site swelling (10.5%), injection site redness (9.5%), nausea (1.1%), malaise (0.5%), and | 03:18 |
| LjL | lymphadenopathy (0.3%)" | 03:18 |
| de-facto | well nothing with high pulse rates in the first week after the mRNA shot, but some moderate movement may be important to lower thrombosis risk | 03:18 |
| LjL | and yet... i only had pain at the injection site after the first shot, and basically nothing at all after the second | 03:19 |
| * LjL shrugs | 03:19 | |
| LjL | (maybe my immune system doesn't work though) | 03:19 |
| de-facto | no reactogenicity is not necessarily linked to immunogenicity | 03:20 |
| LjL | i'd be curious to take an antibody test, they're cheap enough | 03:20 |
| LjL | but | 03:20 |
| de-facto | e.g. they found similar levels of antibodies in people with side effects compared to those with almost no side effects | 03:20 |
| LjL | to get it, i'd be going to the place where all the people who suspect they have COVID are going to get tested :P | 03:21 |
| LjL | so i'd be curious but also, eeeeeeh | 03:21 |
| de-facto | i thought you got your super 3M Aura FFP3 didnt you? | 03:21 |
| de-facto | if not get one, go ahead | 03:22 |
| LjL | hehe, yes, i do, although i have *one* and it got rather wet when i got my second dose, so i should probably get another | 03:22 |
| de-facto | why not, they are also used by medical personal | 03:22 |
| LjL | but i don't think masks are magical, even good ones | 03:22 |
| LjL | (wait, actually you said FFP3, no, I have an Aura FFP2) | 03:23 |
| de-facto | yeah but with tight fit they seem to give quite good protection, of course never 100% | 03:23 |
| de-facto | there is also an FFP3 version of it | 03:23 |
| LjL | but the FFP2 alone is €5.50 | 03:23 |
| LjL | there is also the famous version with a *covered* valve, but it's like €35 and not really available anywhere :P | 03:23 |
| de-facto | no there are many 3M 9330+ Aura FFP3 NR D without valve for under 5€ per piece | 03:27 |
| de-facto | i even could buy another brand FFP3 (with valve) for ~7€ per piece back in fall of 2020 for my parents | 03:28 |
| LjL | if i buy like 20, yeah | 03:28 |
| LjL | one piece is €6.98 on my amazon | 03:29 |
| LjL | 20 pieces are €72 | 03:29 |
| de-facto | yeah other places sell single masks for under 5€ plus delivery ofc | 03:29 |
| de-facto | so not 35€ they became much cheaper | 03:30 |
| LjL | the thing is i don't use these often | 03:30 |
| LjL | they reeeeally make it all very wet very quickly around my mouth, especially in the summer, regardless of what others say, that's my experience | 03:31 |
| de-facto | anyhow you probably can also go with your FFP2, you should most probably be just fine, i would do it in your place | 03:31 |
| LjL | so if i'm just doing random stuff, i wear simpler masks | 03:31 |
| LjL | i keep the Aura for going to medical places | 03:31 |
| de-facto | yeah i always have one or two replacement in my pocket in case they get wet | 03:31 |
| de-facto | yeah same (but not with Aura) | 03:32 |
| LjL | why not? | 03:32 |
| de-facto | i still got enough of what i bought back in fall of 2020 | 03:32 |
| LjL | which is what, that German brand? | 03:32 |
| LjL | i wish something like an Aura had *decent* straps | 03:33 |
| LjL | the straps in my very first FFP2 masks were wonderful (the rest of the mask i dunno) | 03:33 |
| de-facto | yeah they still are good enough | 03:33 |
| LjL | meh they're *stapled* to the mask... if you aren't careful you can hurt your face/eyes, and/or break the straps | 03:33 |
| LjL | it means that i don't use it at the dentist's for instance, i don't use anywhere that i have to take it off and then back on | 03:34 |
| LjL | because i'll make a mess when trying to put it back on and i'm not calmly at home | 03:34 |
| de-facto | i always put them on when i enter buildings and off when i leave them | 03:35 |
| de-facto | i put them on my arm, so they can dry | 03:35 |
| LjL | oh dTal today on TV they showed some italian researchers who were, err... researching... something about COVID, i don't remember what (go me), and one of them was briefly shown with what was clearly a GVS respirator of the kind you use | 03:35 |
| Brainstorm | Updates for Nigeria: +535 cases (now 172263), +5 deaths (now 2139) since a day ago — Bulgaria: +216 cases (now 424295), +2 deaths (now 18205) since a day ago | 03:36 |
| de-facto | "Via Roma, 50 - 40069 Zola Predosa (Bologna) - Italy" | 03:36 |
| LjL | de-facto, if i put it on when i leave the apartment, then off when i get out of the building, then on again when i enter the dentist's building, then off for the dental procedure, then on again, then off, then on in my building, i'm pretty sure at some step the straps will break or i will end up with a staple in my eye :P | 03:37 |
| LjL | what's that address? | 03:37 |
| de-facto | GVS | 03:37 |
| LjL | ah, yeah they're italian, but i think the respirator is produced in the UK | 03:37 |
| de-facto | oh that could be the case, i dont know where they are produced | 03:38 |
| LjL | i think we looked into that a bit a few months ago | 03:38 |
| de-facto | yeah i just take them off as often as possible to let it dry, because then the filter works better | 03:39 |
| de-facto | people just put the straps around their arm so the mask is right above their elbow, its out of the way and does not touch anything, hence can dry without being contaminated | 03:40 |
| de-facto | not sure who came up with that idea, i imitated it and it indeed works quite well | 03:41 |
| LjL | until quite recently masks were mandatory indoors *and* outdoors here, i'm barely starting to be used to taking it off outdoors | 03:41 |
| de-facto | now basically everybody does that here | 03:41 |
| de-facto | oh in crowded places i definitely would also wear it outdoors | 03:42 |
| LjL | i've seen it a lot here too, i'm just saying that compared to the (worse, i know) masks with straps around the ear, the Aura is really finicky to take on and off | 03:42 |
| LjL | (especially on) | 03:42 |
| de-facto | but not if i bicycle or such, i did that and it works, but the mask gets wet | 03:42 |
| de-facto | and wet masks dont protect well anymore, hence i want to avoid that and have a dry mask when i enter a building with potential aerosol | 03:43 |
| Brainstorm | Updates for Martinique: +1934 cases (now 19149), +7 deaths (now 111) since a day ago — Fr. Polynesia: +142 cases (now 19636) since a day ago | 04:00 |
| Brainstorm | Updates for British Virgin Islands: +111 cases (now 2500), +6 deaths (now 31) since 4 days ago | 04:38 |
| LjL | de-facto, ah, look, the very first FFP2 mask i had was very similar to this (although i don't think it was Dräger): https://www.amazon.it/Dr%C3%A4ger-10-polvere-Maschere-Mascherina-protezione/dp/B00UXKS4NC/ with this particular strap arrangement that "slides" within the mask so it's very easy to put it on | 04:54 |
| LjL | unfortunately they were also valved, like these ones | 04:54 |
| LjL | they were really very similar, they also had this "curtain" to cover the nose https://m.media-amazon.com/images/I/61N3DU2MdKL._AC_SL1500_.jpg | 04:56 |
| LjL | i want these without the valve | 04:57 |
| LjL | they have https://www.amazon.it/Dr%C3%A4ger-Mascherina-antipolvere-certificata-costruzione/dp/B08NXMQ1DS/ without a valve but while they don't look horrible (looks like some nose padding), they are definitely a different type | 05:03 |
| Brainstorm | New from The Indian Express: World: Big Tech starts requiring Covid-19 vaccines; Twitter closes re-opened US offices → https://is.gd/Nt2OfD | 05:04 |
| Brainstorm | Updates for Mexico: +19028 cases (now 2.8 million), +537 deaths (now 239616) since 23 hours ago — Thailand: +17669 cases (now 561030), +165 deaths (now 4562) since a day ago — United Kingdom: +19127 cases (now 5.8 million), +95 deaths (now 129542) since 22 hours ago — France: +20672 cases (now 6.1 million), +30 deaths (now 111817) since 22 hours ago | 05:40 |
| Brainstorm | New from This Week In Virology: TWiV 786: You make mucus and you move it: TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. → https://is.gd/wOV0OV | 06:16 |
| Brainstorm | Updates for Germany: +6957 cases (now 3.8 million) since 17 hours ago — Belgium: +2059 cases (now 1.1 million), +1 deaths (now 25231) since a day ago | 06:30 |
| Bridgestorm | ❗ 地震预警 / EARTHQUAKE WARNING for Taiwan (just felt near Tainan?) — Follow for updates (www.kmoni.bosai.go.jp) | 06:34 |
| Bridgestorm | ❗ 地震预警 / EARTHQUAKE WARNING for Taiwan (just felt near Tainan?) — Follow for updates (Twitter) | 06:34 |
| Bridgestorm | ❗ ⭕ 地震! Earthquake! 6.3 M tremor, registered by yurekuru, occurred 1 minute ago (04:32:53 UTC), during daytime, Tainan, Taiwan (22.9, 120.2), ↓10 km likely felt 330 km away (in 臺南市, 高雄市, 永康區, 安南區, 仁德區…) by 7.2 million people → https://twitter.com/yurekuru/status/1420603456880922625 — Webcams: https://www.windy.com/webcams/1597054741 https://www.windy.com/webcams/1590071115 | 06:34 |
| Bridgestorm | https://www.windy.com/webcams/1605519357 (Twitter) | 06:34 |
| Brainstorm | New from The Indian Express: World: Citing new data, Pfizer outlines case for booster shots → https://is.gd/X41VjP | 06:37 |
| Brainstorm | New from r/WorldNews: worldnews: Fiji set to get vaccines from NZ following Medsafe approval → https://is.gd/mzOfxI | 06:47 |
| himesama | what impaired innate rsponses? | 06:55 |
| himesama | is johnson and johnson a bad idea, or, atlernatively, is it a big enough boost in protection. and will it play nice with future variant stuff or mix and match stuff. | 06:56 |
| Brainstorm | New from r/WorldNews: worldnews: Inoculate anyone who wants a COVID-19 vaccine shot, says Philippines' President Duterte → https://is.gd/3ObzFa | 06:57 |
| Brainstorm | New from The Indian Express: World: After a long lockdown and vaccination campaign, is England on the road to normality? → https://is.gd/CsP27D | 07:08 |
| Brainstorm | Updates for Pakistan: +4497 cases (now 1.0 million), +76 deaths (now 23209) since a day ago — Tokyo, Japan: +3177 cases (now 206813), +23 deaths (now 2285) since a day ago — Alabama, United States: +2726 cases (now 577463), +18 deaths (now 11510) since a day ago — Sindh, Pakistan: +2672 cases (now 374434), +43 deaths (now 5903) since a day ago | 07:32 |
| himesama | the us infection map looks like a vaccination map. i hope the new ac installers aren't lying about being vaccinated. (ffirst one screwed up.) | 07:36 |
| Didigy[m] | <LjL "> If batches used in the real wo"> 2 things stand out for me re the 'tainted' injections: | 07:37 |
| Brainstorm | New from The Indian Express: World: Covid-19 lockdown negatively impacted women’s nutrition in India: Study → https://is.gd/zNUNEM | 07:59 |
| -Bridgestorm- ❗ POSSIBLE TSUNAMI for Alaska Peninsula Alaska Peninsula Alaska Peninsula! 🌊 Monitor http://www.tsunami.gov/ http://www.jma.go.jp/en/tsunami/ http://www.bom.gov.au/tsunami/ https://goo.gl/CGAt5M https://goo.gl/CuQMfg https://goo.gl/pJfbGy (webservices.ingv.it) | 08:29 | |
| -Bridgestorm- ❗ 🌊 Earthquake! 7.6 Mwpd tremor, registered by 5 agencies, occurred 14 minutes ago (06:15:47 UTC), during twilight, Alaska Peninsula (55.44, -157.96) ± 11 km, ↓7 km likely felt 730 km away with possible tsunami — Webcams: https://www.windy.com/webcams/1479586870 https://www.windy.com/webcams/1479586858 https://www.windy.com/webcams/1479586839 (webservices.ingv.it) | 08:30 | |
| Brainstorm | Updates for India: +43509 cases (now 31.5 million), +600 deaths (now 422460) since 14 hours ago | 08:34 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Pemetrexed Pfizer (previously known as Pemetrexed Hospira UK Limited), pemetrexed, Carcinoma, Non-Small-Cell Lung,Mesothelioma, Date of authorisation: 24/04/2017, Revision: 7, Status: Withdrawn → https://is.gd/6ypxkE | 08:51 |
| Didigy[m] | An assessment of current 'vaccines' from the co-inventor of mRNA technology (and has had both injections of Pfizer) - https://rumble.com/vkfz1v-the-vaccine-causes-the-virus-to-be-more-dangerous.html?mref=23gga&mrefc=3 | 08:57 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | July 29, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/JXeHSO | 09:01 |
| -Bridgestorm- ❗ POSSIBLE TSUNAMI for Alaska Peninsula! 🌊 Monitor https://t.co/5Gqipznljp (Twitter) | 09:11 | |
| -Bridgestorm- ❗ 🌊 Earthquake! 8.2 M tremor, registered by quakenotices, occurred 55 minutes ago (06:15:49 UTC), during twilight, Alaska Peninsula (55.5, -157.9), ↓10 km likely felt 800 km away with possible tsunami → https://t.co/5Gqipznljp — Webcams: https://www.windy.com/webcams/1479586870 https://www.windy.com/webcams/1479586858 https://www.windy.com/webcams/1479586839 (Twitter) | 09:11 | |
| Brainstorm | Updates for Uzbekistan: +879 cases (now 127506), +6 deaths (now 859) since 23 hours ago | 09:30 |
| -RSSBot[LjLmatrix- Feed: Consiglio dei Ministri n. 31 ( https://www.governo.it/it/articolo/consiglio-dei-ministri-n-31/17542 ) | 09:48 | |
| -RSSBot[LjLmatrix- Feed: Convocazione del Consiglio dei Ministri n. 31 ( https://www.governo.it/it/articolo/convocazione-del-consiglio-dei-ministri-n-31/17543 ) | 09:48 | |
| Brainstorm | Updates for Lithuania: +410 cases (now 282039), +1 deaths (now 4413) since a day ago | 10:07 |
| Brainstorm | New from r/WorldNews: worldnews: Thankful for vaccines, Taiwan praises Czech Republic as democracy partner → https://is.gd/iBIvXZ | 10:34 |
| Brainstorm | New from The Indian Express: World: Europe on vacation, but vaccinations not taking a break → https://is.gd/HimfNN | 10:44 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Fluad Tetra, influenza vaccine (surface antigen, inactivated, adjuvanted), Influenza, Human, Date of authorisation: 20/05/2020, Revision: 2, Status: Authorised → https://is.gd/Vk8v6Y | 10:55 |
| Brainstorm | Updates for Estonia: +220 cases (now 133111), +1 deaths (now 1272) since a day ago | 11:10 |
| Brainstorm | New from ProPublica: The Women on the Other End of the Phone: by Brooke Stephenson ] ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up for Dispatches , a newsletter that spotlights wrongdoing around the country, to receive our stories in your inbox every week. For almost a decade, ProPublica has been reporting on the ways [... want %more?] → https://is.gd/rSdWE7 | 11:15 |
| -RSSBot[LjLmatrix- Feed: Il Presidente Draghi al G20 Cultura ( https://www.governo.it/it/articolo/il-presidente-del-consiglio-draghi-al-g20-cultura/17545 ) | 11:38 | |
| -RSSBot[LjLmatrix- Feed: Nota della Presidenza del Consiglio dei Ministri ( https://www.governo.it/it/articolo/nota-della-presidenza-del-consiglio-dei-ministri/17546 ) | 11:38 | |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Comirnaty, COVID-19 mRNA vaccine (nucleoside-modified), COVID-19 virus infection, Date of authorisation: 21/12/2020, Revision: 10, Status: Authorised → https://is.gd/golaYG | 11:47 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Flucelvax Tetra, influenza vaccine (surface antigen, inactivated, prepared in cell cultures), Influenza, Human, Date of authorisation: 12/12/2018, Revision: 9, Status: Authorised → https://is.gd/X67dla | 12:18 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Zostavax, shingles (herpes zoster) vaccine (live), Herpes Zoster,Immunization, Date of authorisation: 19/05/2006, Revision: 30, Status: Authorised → https://is.gd/GRGFCB | 12:28 |
| Brainstorm | Updates for Canada: +10 deaths (now 26570) since 18 hours ago | 12:37 |
| Brainstorm | New from r/WorldNews: worldnews: COVID Symptoms May Linger In Some Vaccinated People Who Get Infected, Study Finds → https://is.gd/CCcXiK | 12:49 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Fluenz Tetra, influenza vaccine (live attenuated, nasal), Influenza, Human, Date of authorisation: 04/12/2013, Revision: 21, Status: Authorised → https://is.gd/WaYEgs | 13:00 |
| Brainstorm | New from ECDC: Data on the daily number of new reported COVID-19 cases and deaths by EU/EEA country: The downloadable data file is updated daily and contains the latest available public data on COVID-19. Each row/entry contains the number of new cases and deaths reported per day and per country in the EU/EEA. → https://is.gd/tBASDi | 13:31 |
| Brainstorm | Updates for Finland: +765 cases (now 105260) since a day ago | 13:39 |
| Brainstorm | New from ECDC: Data on COVID-19 vaccination in the EU/EEA: The downloadable data files contain information on COVID-19 vaccination in the EU/EEA. The data are presented in the Vaccine Tracker and collected through The European Surveillance System (TESSy). → https://is.gd/tmWhQm | 13:42 |
| Brainstorm | New from ECDC: ECDC: Data for the maps in support of the Council Recommendation on a coordinated approach to the restriction of free movement in response to the COVID-19 pandemic in the EU/EEA → https://is.gd/o2qmzJ | 13:52 |
| Brainstorm | New from ECDC: ECDC: Combined indicator: 14-day notification rate, testing rate and test positivity, updated 29 July 2021, weeks 28-29 → https://is.gd/8el6hR | 14:02 |
| Brainstorm | New from The Indian Express: World: AstraZeneca to apply for COVID-19 vaccine approval in US later in 2021 → https://is.gd/sLQt4r | 14:24 |
| Brainstorm | Updates for Iceland: +131 cases (now 7676) since a day ago — Nepal: +2335 cases (now 690642), +16 deaths (now 9807) since 23 hours ago | 14:41 |
| aradesh | coincidental timing: https://ec.europa.eu/health/sites/default/files/vaccination/docs/2019-2022_roadmap_en.pdf | 14:55 |
| aradesh | unfortunate timing for conspiracies | 14:58 |
| Brainstorm | New from r/WorldNews: worldnews: China Used Vaccines, Trade To Get Ukraine To Drop Support For Xinjiang Scrutiny → https://is.gd/Q55r0b | 15:06 |
| specing | > AstraZeneca to apply for COVID-19 vaccine approval in US | 15:09 |
| specing | lol | 15:09 |
| specing | people here are rejecting AZ due to many many side effects | 15:09 |
| Brainstorm | New from Medical Xpress: Prevention of coronavirus infection spread through aerosols: As the development of the COVID-19 pandemic to date has shown: aerosols contribute significantly to the occurrence of infection—and combating them can significantly reduce a resurgence of infection levels. The question of effective protective measures will become [... want %more?] → https://is.gd/uKQmIu | 15:16 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Emergent to resume Covid-19 vaccine production; FDA OKs first interchangeable biosimilar insulin → https://is.gd/pkFaqc | 15:27 |
| Brainstorm | Updates for Switzerland: +827 cases (now 716865) since 23 hours ago | 15:31 |
| Brainstorm | New from The Indian Express (Health): Life-style: Cycling league in Hyderabad helps enthusiasts rediscover themselves amid pandemic → https://is.gd/D66zPz | 15:48 |
| Brainstorm | New from NPR: Disney Will Begin Requiring Masks Again Indoors At Its Theme Parks In The U.S.: With cases of the coronavirus back on the rise in Florida and California, guests two years of age and older at Disney World and Disneyland will again be required to don masks starting on Friday. → https://is.gd/9sUH1Q | 16:10 |
| Brainstorm | New from In The Pipeline: How Not to Be That Chemist: I enjoyed this Twitter thread very much from “Bob the Grumpy Med Chemist”. It leads off with a document that pops up periodically on the internet, a guide to sabotage that was put out by the OSS (precursor to the CIA) during the second World War. Along with practical suggestions about how to [... want %more?] → https://is.gd/1SvbPa | 16:30 |
| joerg | specing: >>many many side effects<< oh? which ones? | 17:00 |
| joerg | re US approval I also scratched head | 17:00 |
| joerg | though rather because I had thought they already are approved in US | 17:01 |
| Brainstorm | New from r/WorldNews: worldnews: COVID-19: Outbreak declared in Central Okanagan, new measures enacted → https://is.gd/DO2ZLf | 17:02 |
| specing | joerg: https://www.ema.europa.eu/documents/covid-19-vaccine-safety-update/covid-19-vaccine-safety-update-vaxzevria-previously-covid-19-vaccine-astrazeneca-14-july-2021_en.pdf | 17:05 |
| joerg | specing: thanks. Those don't look like "many many" to me, but that's probably my very subjective metrics | 17:10 |
| Brainstorm | Updates for Bangladesh: +15271 cases (now 1.2 million), +239 deaths (now 20255) since 23 hours ago | 17:10 |
| specing | joerg: it's many compared to e.g. pfizer(just myocarditis/pericarditis) | 17:16 |
| LjL | <specing> people here are rejecting AZ due to many many side effects ← "many many"? what's the deal apart from the rare thrombosis? | 17:19 |
| joerg | specing: that's true | 17:19 |
| LjL | ah i see | 17:20 |
| specing | LjL: Guillain-Barré syndrome (GBS) Immune thrombocytopenia (ITP) Acute macular neuroretinopathy (AMN) Myocarditis and pericarditis Thrombosis with thrombocytopenia syndrome (TTS) | 17:20 |
| specing | For half of these the causality doesen't seem to be established yet, but I suppose the data did warrant an investigation | 17:21 |
| joerg | an investigation is almost always warranted | 17:22 |
| LjL | but then, i think GBS has been reported for other vaccines and also after infections so it may "just" be something that an immune system reaction does sometimes; ITP and TTS are related to the same phenomenon, and are the "big ones" we know about; myocarditis/pericarditis is also triggered by Pfizer; AMN, okay, that one is new to me, not sure if there's a causal link established | 17:22 |
| specing | PRAC assessed cases of acute macular neuroretinopathy (AMN), a rare | 17:23 |
| specing | condition characterised by sudden onset of one or more paracentral | 17:23 |
| specing | scotomas, i.e. spots that partially obstruct vision. This condition has been | 17:23 |
| specing | reported very rarely after vaccination with Vaxzevria. For this assessment, | 17:23 |
| specing | ophthalmological diagnosis and causality are considered in each case. | 17:23 |
| specing | PRAC has requested further data and analyses from the marketing | 17:23 |
| specing | authorisation holder to continue its assessment of whether AMN could | 17:23 |
| Brainstorm | New from BBC Health: (news): Covid vaccines have prevented 60,000 deaths in England - Jonathan Van-Tam → https://is.gd/I4rXeJ | 17:24 |
| * joerg doesn't like the vector virus vaccine approach anyway. Nevertheless got AZ as first shot | 17:27 | |
| Brainstorm | New from ClinicalTrials.gov: (news): Intervention to Promote COVID-19 Vaccination → https://is.gd/wqfvfd | 17:36 |
| joerg | quite interesting (German RKI): 20% imported by vacation travelers https://i.imgur.com/fDqLiUw.png and a nice graphic "heatmap" time(X) vs age(Y) number of incidences https://i.imgur.com/xJS42Sx.png both from weekly covid situation report https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/Jul_2021/2021-07-29-de.pdf?__blob=publicationFile | 17:58 |
| joerg | sorry google translate fails with "page is too large..." | 18:00 |
| joerg | of course you still could c&p page per page of the original pdf to get it translated | 18:00 |
| Brainstorm | Updates for United Kingdom: +30069 cases (now 5.8 million) since 23 hours ago | 18:37 |
| LjL | specing: I don't suppose we have an idea how long after administration of the vaccine these various "effects of interest" are being reported, unless we go analyze the EU equivalent of VAERS in detail assuming it's public? | 18:51 |
| specing | We don't | 18:51 |
| specing | I also hadn't seen a side effect breakdown by sex/age/other factors | 18:52 |
| specing | But I did hear that *carditis mostly occurs in younger men | 18:52 |
| joerg | and iirc usually cures without much complication? | 18:55 |
| joerg | might be wrong | 18:55 |
| * joerg worries about rpifan's status | 18:57 | |
| Brainstorm | New from WebMD: Pandemic Boosted Paranoia and Conspiracy Theories: Researchers have detected increased levels of paranoia and erratic behavior among the general population in the United States during the pandemic. → https://is.gd/BwYDco | 19:00 |
| Brainstorm | Updates for Canada: +13 deaths (now 26573) since 16 hours ago | 19:02 |
| LjL | specing: I heard about myocarditis occurring in young males but that was about Pfizer (could be the same with AZ I just haven't heard about that) | 19:15 |
| LjL | But since in the case of AZ it still seems to be tied to the thrombocytopenia, it may be more prevalent in females instead | 19:15 |
| specing | LjL: yes, the myocarditis thing was about Pfizer | 19:16 |
| Brainstorm | Updates for Italy: +6167 cases (now 4.3 million), +19 deaths (now 128029) since a day ago — St. Pierre and Miq.: +2 cases (now 28) since a month ago — Germany: +4389 cases (now 3.8 million) since 23 hours ago | 19:39 |
| LjL | Israel is giving a third vaccine dose, starting from next Sunday, to over 65 | 20:11 |
| LjL | if they had their second dose more than 5 months ago | 20:11 |
| Brainstorm | New from New Scientist: Covid-19 news: Daily new cases in the UK rise to 31,117: The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic → https://is.gd/dZAksW | 20:13 |
| LjL | %title https://www.nature.com/articles/d41586-021-01917-9 | 20:16 |
| Brainstorm | LjL: From www.nature.com: This ‘super antibody’ for COVID fights off multiple coronaviruses | 20:16 |
| -RSSBot[LjLmatrix- Feed: Comunicato stampa del Consiglio dei Ministri n. 31 ( https://www.governo.it/it/articolo/comunicato-stampa-del-consiglio-dei-ministri-n-31/17552 ) | 20:28 | |
| Brainstorm | New from StatNews: Listen: The quest for a Covid pill, a microbiome gut-check, & CRISPR on the big screen: How long do vaccines last? Is the microbiome overhyped? And who should play Jennifer Doudna in a movie? All that and more on the latest episode of "The Readout LOUD."… → https://is.gd/XkuTIw | 20:55 |
| nixonix | .title https://thehill.com/changing-america/well-being/longevity/565323-texas-doctor-warns-covid-cases-are-rising-among | 20:59 |
| Brainstorm | nixonix: From thehill.com: Texas doctor warns COVID-19 cases are rising among children | TheHill | 20:59 |
| nixonix | https://twitter.com/yaneerbaryam/status/1420484703941971980 | 21:05 |
| nixonix | .title https://www.timesofisrael.com/israelis-age-60-and-up-to-start-getting-third-coronavirus-vaccine-dose-next-week/ | 21:07 |
| Brainstorm | nixonix: From www.timesofisrael.com: Israelis age 60 and up to start getting third coronavirus vaccine dose next week | The Times of Israel | 21:07 |
| nixonix | https://twitter.com/ByJamesKeller/status/1420740393704902669 | 21:07 |
| nixonix | "Alberta will no longer require people who test positive for COVID-19 to isolate and will stop routine testing for mild symptoms | 21:08 |
| nixonix | https://twitter.com/GYamey/status/1420379853300379651 | 21:10 |
| nixonix | there seems to be t-cell related interference from previous hcov infections, which isnt necessarily good, but hard to say for sure yet if its bad - or somewhere inbetween... | 21:13 |
| nixonix | https://twitter.com/fitterhappierAJ/status/1420788137807200263 | 21:13 |
| nixonix | children are affected less, but is it because less encounters with hcovs or just that t-cell immunity wanes for them (they usually have had lot of hcovs in early age anyway) | 21:15 |
| nixonix | .title https://www.nature.com/articles/s41467-021-24938-4 | 21:16 |
| Brainstorm | nixonix: From www.nature.com: SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection | Nature Communications | 21:16 |
| nixonix | reduced prior β-coronavirus immunity and reduced T cell activation in children might drive milder COVID-19 pathogenesis | 21:16 |
| nixonix | The smaller magnitude of SASR-CoV-2 memory T cell responses in children than adults, may imply a weaker long-term memory response in children potentially impacting outcomes at reinfection | 21:19 |
| nixonix | children can also get the same hcov infection faster than adults | 21:20 |
| nixonix | .title https://science.sciencemag.org/content/early/2021/07/28/science.abj0299 | 21:30 |
| Brainstorm | nixonix: From science.sciencemag.org: Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates | Science | 21:30 |
| nixonix | Lower antibody levels are needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273-induced IgG to naïve hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccine-induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs | 21:31 |
| nixonix | so if its the same with humans, when ab titers go down, people will get infected but lungs should be protected. at least longer | 21:33 |
| LjL | <Brainstorm> New from EuroNews: (news): A majority want working from home to continue, new survey finds → https://is.gd/RpSTAy | 21:35 |
| nixonix | israel: Health Ministry have recommended that older people receive a third dose of the coronavirus vaccine, after data suggested that the vaccine's effectiveness in preventing severe symptoms among 60-year-olds and above has dropped to 81 percent from 97 percent in January | 21:36 |
| LjL | that decision by Alberta looks appalling | 21:37 |
| Brainstorm | New from WebMD: New Vaccinations Increasing in COVID Hot Spots: States struggling with alarming COVID-19 outbreaks are now vaccinating people at very high rates, an analysis of CDC data shows. → https://is.gd/yWhnHd | 21:37 |
| Brainstorm | Updates for Eswatini: +601 cases (now 24848), +2 deaths (now 772) since a day ago — France: +16841 cases (now 6.1 million) since 19 hours ago | 21:37 |
| LjL | 81% for severe symptoms :\ | 21:39 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.07.12.21260385v1.full | 21:54 |
| Brainstorm | nixonix: From www.medrxiv.org: Estimating the effectiveness of first dose of COVID-19 vaccine against mortality in England: a quasi-experimental study | medRxiv | 21:54 |
| nixonix | .title https://www.haaretz.com/israel-news/israeli-health-ministry-panel-recommends-third-covid-shot-for-older-people-1.10049085 | 21:57 |
| Brainstorm | nixonix: From www.haaretz.com: Health Ministry experts panel recommends 3rd COVID shot for older Israelis - Israel News - Haaretz.com | 21:57 |
| nixonix | Severe COVID-19 was strongly associated with recent exposure to hospital (defined as 5 to 14 days before presentation date): rate ratio 12.3 (95% CI 11.5 to 13.2) overall. | 22:18 |
| nixonix | .title https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02021-5 | 22:19 |
| Brainstorm | nixonix: From bmcmedicine.biomedcentral.com: Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study | BMC Medicine | Full Text | 22:19 |
| Brainstorm | New from StatNews: Biden wants $100 rewards for those who get vaccinated against Covid-19 — but there’s little he can do to make it happen: Biden wants states to give $100 to people who get vaccinated against Covid-19. He wants to require federal workers and the military to get immunized, too. But it’s entirely unclear… → https://is.gd/hSTV6N | 22:19 |
| nixonix | https://twitter.com/abledoc/status/1420282160460681220 | 22:19 |
| nixonix | .title https://www.npr.org/sections/health-shots/2021/07/28/1021888033/breakthrough-infections-may-cause-long-covid-symptoms-small-study-suggests | 22:26 |
| Brainstorm | nixonix: From www.npr.org: NPR Cookie Consent and Choices | 22:26 |
| nixonix | before indian variant, tho. it made lots of studies obsolete | 22:27 |
| nixonix | .title https://www.bbc.com/news/world-europe-58003893 | 22:38 |
| Brainstorm | nixonix: From www.bbc.com: Covid: Stalled Russian vaccines cause global anger - BBC News | 22:38 |
| Brainstorm | Updates for Spain: +26689 cases (now 4.4 million), +46 deaths (now 81442) since a day ago — Ethiopia: +476 cases (now 279629), +5 deaths (now 4381) since 23 hours ago | 22:40 |
| LjL | nixonix, i'll certainly try not to go to hospital | 22:43 |
| nixonix | some rural yank once said, that he avoids hospitals any way he can. not sure if it was because he thought they were bad for health or for wallet | 22:45 |
| nixonix | more rocketeers: cuba, montenegro, georgia ex-soviet, florida | 22:48 |
| nixonix | finland going strong uphill too, with minimal restrictions, lots of festivals coming etc | 22:54 |
| nixonix | germ festivals, happy go lucky | 22:54 |
| nixonix | we are copying uk model. doesnt matter that hey might have 90% immunity or so, and we have 5% max from infections, and much lower vaccine coverage too | 22:55 |
| nixonix | its our turn to be a warning example | 22:56 |
| nixonix | hey=they | 22:56 |
| nixonix | funny case peak in germany, in offloop. maybe some backlog data | 22:57 |
| de-facto | RKI Germany says: Weekly Incidence 16/100k, +3,142 cases, +21 deaths | 23:04 |
| de-facto | weird that offloop got a +10.735 peak at latest datapoint, either an artefact or something happened | 23:05 |
| mikimausokk[m] | covid is fake pandemic | 23:06 |
| LjL | mikimausokk[m], then leave | 23:07 |
| LjL | this is for people who are concerned with it | 23:07 |
| de-facto | mikimausokk[m], tell that the relatives of those that died, prepare for their answer | 23:08 |
| specing | https://www.nature.com/articles/d41586-021-01813-2 Mounting evidence suggests Sputnik COVID vaccine is safe and effective | 23:09 |
| specing | NO BLOOD CLOTTING ?!?! | 23:09 |
| LjL | https://github.com/ljl-covid/links/blob/master/COVID-19-chat.md | 23:09 |
| LjL | specing, considering it's being given to millions of people, i'd have hoped that there was already evidence of safety and effectiveness :P | 23:09 |
| specing | LjL: yeah | 23:09 |
| LjL | anyway given the article linked by nixonix, good that it's safe and effective, now if it were actually also produced and distributed... | 23:10 |
| specing | Heh, yeah | 23:11 |
| specing | Article says it's 97+% effective | 23:11 |
| nixonix | "The Russian vaccine Sputnik has never been able to get approval from EMA and perhaps it never will," Draghi said. | 23:12 |
| LjL | maybe that's good, but also, maybe it was already pre-decided by the EU | 23:14 |
| LjL | although they say they haven't submitted authorization request data | 23:14 |
| LjL | such geopolitical dancing | 23:14 |
| specing | I find missing data quite believable when it comes to russia, though :P | 23:14 |
| nixonix | .title https://www.reuters.com/world/the-great-reboot/exclusive-european-efforts-assess-russias-sputnik-v-vaccine-stymied-by-data-gaps-2021-07-13/ | 23:16 |
| Brainstorm | nixonix: From www.reuters.com: EXCLUSIVE European efforts to assess Russia’s Sputnik V vaccine stymied by data gaps | Reuters | 23:16 |
| nixonix | that two different vector wasnt probably that great idea. sure anyone could have done that too, but theres the production problem, you need two different products | 23:19 |
| nixonix | also Ad5 suffers from previous immunity to common virus | 23:20 |
| nixonix | some chimp or gorilla adenovirus and ad26 would have been better combination | 23:20 |
| nixonix | but supposedly ad5 is the easiest to use | 23:20 |
| nixonix | whats the best chinese rona vacc? | 23:21 |
| Brainstorm | New from CIDRAP: Israeli advisors back COVID vaccine boosters for older people: Lisa Schnirring | News Editor | CIDRAP News Jul 29, 2021 Meanwhile, Africa's vaccine supply showed improvements and Delta-driven surges increased in parts of Asia and the Middle East. → https://is.gd/U3abHv | 23:22 |
| nixonix | https://twitter.com/itosettiMD_MBA/status/1420537209879416833 | 23:23 |
| specing | > that fetal bovine serum had been used in the culture to nurture the master cell bank and that the developers hadn’t documented the serum’s origin. | 23:23 |
| specing | the inspectors should have seen the cow in institute's backyard, lol | 23:23 |
| specing | nixonix: so, combinining AZ and ad26 of sputnik? | 23:24 |
| nixonix | yeah, they were planning to do that | 23:24 |
| nixonix | but then those problems with their data, EMA etc | 23:25 |
| specing | I remeember that about a year ago, we were told that sputnik wouldn't work in europe anyway due to immunity to the vector | 23:25 |
| specing | > After this story was published, RDIF in a statement said the assertion about the use of untraceable bovine serum was “false,” without going into specifics. | 23:25 |
| specing | why the heck is the investment fund responding to this? | 23:26 |
| nixonix | it varies a lot, immunity to ad26. ive read its about 50% in average, but depends on area and time. maybe currently less due to all the restrictions reducing spreading of many viruses (exp rhinos) | 23:26 |
| specing | i'd expect the response to come from Gamaleya and *only* Gamaleya | 23:26 |
| nixonix | i mean Ad5 | 23:26 |
| de-facto | well what does "immunity" actually mean? | 23:27 |
| de-facto | some antibodies, but maybe not enough at the injection site to prevent the viral vector to enter enough cells and deliver the payload? | 23:28 |
| Brainstorm | Updates for Togo: +129 cases (now 15522) since 21 hours ago — Aruba: +63 cases (now 11584), +1 deaths (now 110) since 23 hours ago | 23:29 |
| de-facto | its not like Janssen would not work in half of the cases or such | 23:29 |
| de-facto | and JnJ does also use Ad.26 | 23:30 |
| nixonix | level of immunity that has an effect, in this case reducing the efficacy of the vaccine. trials tel the reall efficacy, and if it has hit by previous immunity or not | 23:31 |
| nixonix | that problem was with Ad5, not Ad26 | 23:31 |
| nixonix | tell the real - l's the other way... | 23:32 |
| mikimausokk[m] | fake pandemic | 23:33 |
| nixonix | weak troll. they used to be better back in the days | 23:34 |
| de-facto | maybe its a fake troll? :D | 23:37 |
| nixonix | https://twitter.com/NYCMayor/status/1420417525343473664?ref_src=twsrc%5Etfw | 23:41 |
| Brainstorm | New from CIDRAP: Biden: Federal workers must get COVID-19 vaccine: Stephanie Soucheray | News Reporter | CIDRAP News Jul 29, 2021 The president also unveiled a new incentive plan and asked school districts to hold another round of pop-up vaccination for kids agest 12 and up. → https://is.gd/ySqGaf | 23:43 |
| nixonix | ill be damned. "(archaic) second-person singular simple present form of age | 23:45 |
| nixonix | medical workers yeah, maybe teachers, but how can they force all the federal workers take the shot | 23:47 |
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