libera/##covid-19/ Friday, 2021-08-06

nixonix2 hours earlier times. when actually our in our health care institute the party that wants to let it rip now has won, and politicians think thats prob a good idea, we just dont tell it to people and let it rip anyway00:00
BrainstormNew from Ars Technica: Science: Record-setting COVID surge in Florida spurs pro-mask uprising against DeSantis → https://is.gd/pIeP0D00:01
nixonixdid i link whats happening in florida, who have similar vacc coverage than eu average? and lots more immunity from infections than our 5% or so. i think i did00:02
nixonixbrainstorm is a mind reader00:02
nixonixheres some more, florida https://twitter.com/DrEricDing/status/142256918505025126800:04
de-factohmm looks bad, but if the cites from DeSantis are correct i am not surprised00:06
himesamaare any of the let it rippers aware of lc?00:07
himesamaurgent question: the outside of masks was said to be where virions have been found in large numbers.  i put a used half faceplate with its p100 cartridges in a ziploc bag (which means, maybe, it gets all around to the face part also?).  how many days to let it sit to decontaminate?  2-3 days enough?  cannot always clean it.00:09
de-factoit can stay infectious for weeks on certain surfaces00:11
de-factoit decays exponentially though, decay constants depending on circumstances00:11
de-factobtw such masks should be cleaned with the proper liquid on regular basis anyhow, i think for my silicon half mask they would sell me Isopropanol, but it depends on the type of plastic in use, some may loose their softness by the wrong sanitizing agent00:13
de-factoi think i know some people that used isoprop on thermoplastic and it became less soft00:14
de-factothere are many studies about properly sanitizing masks, also with ozone, UV-C, etc00:15
de-factoall depends on the materials and assumed contamination amounts00:15
de-factoi would say 2-3 days are not a guarantee that it is decontaminated00:16
nixonixand half-"life" is increased a lot if there are 1000x viable virions now?00:18
de-factobut it depends on the dose: assuming a certain (fixed) dose is required to start an infection it depends on the contamination dose of the mask how long the exponential decay needs to come below that infectious threshold00:18
de-facto1000.-fold ~ 10 half lifes00:19
nixonix"wish we had 2 virologists, 2 public health whatevers, and 2 epidemiologists here"00:19
himesamathe face part is silicone.  the harness is softish plastic and various materials.  the cartridges are hard plastic.  the valves are soft floppy material.00:19
nixonixand we dont? in two armchairs. immunologists too...00:19
LjL1000x in a swab probably doesn't automatically mean there will be 1000x in a square meter of air00:19
nixonixyeah, we can hope. and viable virions maybe only 10-100x perhas00:20
nixonixps00:20
nixonixi like to read about australia, just dm articles mostly. its strangely fascinating, kind of the sci-fi sub-genre alternate history00:22
himesamai assume silicone is not affected by iso (if i am able to do that which  might nmot) but hte other parts idk00:22
de-factoLjL, hmm why not? just not that its 1000-fold as infectious (if possibly less percentage of them are intact)00:22
himesamathe bag has been in high heat every day above 90f00:23
de-factomost manufacturers got cleaning instructions for their product00:23
de-factoalso maintenance and control00:24
himesamait has a proprietary cleaning solution that it recommends00:25
himesamaand was likely many years ago decided on00:26
de-factoso try to find out the ingredients of that, in order to see material compatibility00:26
de-factothen if it contains some alcohol, bingo00:26
nixonixi wonder if ct bought that 300 dollar mask he was considering00:27
himesamawell i guess whatever i do i try removing cartridges and then cleaning and then putting new cartridges in00:28
de-factootherwise using some hot water with soap also should inactivate quite some of the virions (and wash them away)00:28
de-factoshould be quite compatible with most plastic materials, without weakening its structural integrity00:28
de-factohmm maybe thats what i would do, twice00:29
de-factobut of course not too hot, since thermoplasts got their name for a reason00:31
nixonixhttps://twitter.com/itosettiMD_MBA/status/142340772245261926600:31
BrainstormUpdates for Bulgaria: +500 cases (now 426932), +14 deaths (now 18243) since 23 hours ago — Fr. Polynesia: +489 cases (now 21805), +1 deaths (now 155) since 21 hours ago00:32
BrainstormNew from The Lancet (Online): [Viewpoint] What are the obligations of pharmaceutical companies in a global health emergency?: During a global health emergency, everyone is morally required to help to combat the disease. With approximately 8000–10 000 people dying every day from COVID-19, as of writing, only rapid and globally distributed [... want %more?] → https://is.gd/SSbAt800:33
de-factowould also try to decontaminate the different assumed contamination levels separately00:33
de-factoe.g. the parts of the mask with low assumed contamination level not together with the parts that may have been highly contaminated00:34
nixonixhowcome so many partly vaccinated, with their 3 week dose interval?00:35
-RSSBot[LjLmatrix- Feed: Nota della Presidenza del Consiglio ( https://www.governo.it/it/articolo/nota-della-presidenza-del-consiglio/17594 )00:37
nixonixkids  https://twitter.com/deborahblum/status/142339742437514035400:38
nixonixwaning https://twitter.com/RanIsraeli/status/142332227150302822800:41
BrainstormNew from r/WorldNews: worldnews: Japan's population drops by record number to 126.65 million amid pandemic → https://is.gd/y46hE900:43
nixonixmaybe because they were normalized for size of the group of 1 dosers...00:51
nixonixand age00:51
nixonixAs of Tuesday, Tennessee reported six deaths among children 10 and younger and five deaths among people 11 to 20.00:54
nixonixidk if from the same day or from longer period, though00:54
nixonixhttps://twitter.com/Cleavon_MD/status/142336572920690278400:56
LjLItaly decided for mandatory green pass (aside from in bars, restaurants, events) also for school personnel, university students, and long-hault transport (anything except local and regional transport)01:02
LjLi wonder if there's enough people to do the checks01:03
himesamaso wht is a good amount of time? does that include plastic?  (or do we know)--- 15:11 <de-facto> it can stay infectious for weeks on certain surfaces01:04
nixonixhow about international transport?01:05
nixonixtrucks from cross the border. and why not ship crews01:06
nixonixon pastic virions stayed longer than on paper or cardbord. metal was shortest, esp copper (from memory, over year ago, hope im right...01:07
nixonixboard01:07
nixonixand plastic. damn01:07
nixonixbut you should try to find studies on indian variants virions01:08
LjLi'm taking international transport for granted, that's coordinated across the EU01:10
LjLrapid tests will cost €15 by the way (€8 for kids up to some age), seems like a lot, but i guess they can't be compared to the "supermarket ones", since they're done by pharmacies and you get a green pass for them01:11
specingLjL: no need to do checks, just make monstrous fines for that once-in-a-decade when they actually find you01:11
LjLbut don't Germany and Greece give one or two of this type of tests for free per week?01:11
LjLspecing, yeah that's our public transport has always worked, see how well it has managed to make people actually buy tickets01:12
specingafain in germany the tests are free for all01:12
LjLmy high school friends' standard procedure was just to run faster than ticket collectors01:12
specinghere they are free for everyone with gov insurance and will cease being free at end of this month01:12
LjLthe fact the tests aren't free basically makes vaccination mandatory for school workers. who will decide to take a test every 48 hours instead?01:13
nixonixhavent read much about this, but just read a finnish woman telling everything takes 3 times longer, started to forget names etc01:13
nixonix.title https://www.nature.com/articles/s41380-021-01148-401:13
Brainstormnixonix: From www.nature.com: Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? | Molecular Psychiatry01:13
specingLjL: here the ticket collectors have no right to ID nor apprehend you, so you can just wave them goodbye as you exist at the next stations01:14
LjLfor... what01:14
specing-s01:14
specingLjL: yes01:14
specinggovernments are taking the slow-boiled-frog approach01:14
nixonixaka ME/CFS aka post-infectious myalgic encephalomyelitis/chronic fatigue syndrome01:14
specingsince as you said, mandatory vaccinations would cause riots01:14
dTalwhy are tests for kids cheaper? surely it costs the same to test them. Is it a subsidy? Why not subsidize the lot?01:14
LjLcertainly subsidized01:15
LjLi dunno "why". transport tickets are also cheaper for kids, why?01:15
dTalbut they're not subsidized, they're ridiculously overpriced01:15
dTalmy government literally hands them out free01:16
dTalI can get 7 a day in the mail01:16
LjLif it were my decision, i'd retrospectively justify it as "vaccinating kids is more controversial given the skewed risk/benefit ratio and discoveries of cardiac side effects on younger, so it's more reasonable to just have them tested, so it should cost less"01:16
dTalmaybe I should sell them to you guys on ebay!01:16
LjLdTal, in the mail? those are self-administered test though... can't get a green pass from those01:16
dTaloh so what you're paying for is the wages of test administrators01:17
LjLmaybe01:17
LjLnot sure the tests are quite the same either01:17
dTalthese are lateral flow tests?01:17
dTalbecause "green pass" for lateral flow is stupid01:17
LjLthey are not PCR so... presumably yes?01:17
LjLwell green pass from PCR is not logistically possible01:18
dTalno indeed01:18
LjLgreen pass from a test is valid for 48 hours, it takes more than 48 hours to get a test result01:18
dTalthus throwing the "green pass" concept into question01:18
LjLwell it's been into question from the start01:18
LjLbut, here, we don't tolerate even the slightest hint of green pass skepticism01:18
dTala lateral flow "green pass", if valid at all, should only be valid for a few hours01:19
LjL*cough*01:19
dTal48 hours is ridiculous01:19
LjLi'm not sure why you make it a matter of hours... they're bad because they have false negatives, not because they have a lower predictive time01:19
dTalyou can pass a lateral flow and 48 hours later be coughing like mad01:20
dTalthey're bad because they cannot detect low viral load01:20
dTalso they do not catch early stage infections01:21
dTalso a negatuve lateral flow, at best, means you have a low viral load01:21
dTalwhich does offer some safety to those around you01:21
nixonixarent there riots in france anyway, whatever they decide01:22
dTalbut not for 48 hours! exponential viral growth means that a "low" viral load at t=0 tells you almost nothing about the range of viral loads possible at t=48h01:22
LjLnixonix, i think it's safe to say that, no matter hwat happens, there are riots in france01:25
LjLmeanwhile Punto Informatico is an idiot again01:25
LjLthis time they announced a "bug" in the italian green pass verification app01:25
LjLsomeone filed a bug saying if you change the device's time/date, you can make invalid passes look valid01:26
LjLDUH01:26
LjLexcept that's absolutely irrelevant, because the validity is only shown to the owner of the device making the check01:26
LjLand Punto Informatico has yelled at people who "didn't understand" how the green pass worked enough that they should not publish crap like this01:26
LjLif i'm e.g. a restaurant manager and want to cheat by considering your invalid green pass valid, the easiest way to do that is to scan your pass, see the red "INVALID" result on my screen, and yet say "that's fine, please enter!"01:27
LjLthe app works offline, the result of the scan isn't shown to anybody else, so it's not very hard to understand this "bug" is bugless01:27
nixonixwell, they are planning vax or negative test results (which some politicians are requiring to be free) in finland, for bars and events, that could be ready in october... and now you are telling negative results from rapid tests arent worth a shit after couple of hours01:30
nixonixso basically there will be a farce here later in the fall01:30
nixonixbut if you want to make a lot of money, sell them those tests before they notice01:33
BrainstormNew from r/WorldNews: worldnews: Russian Disinformation Targets Vaccines and the Biden Administration → https://is.gd/znDlVo01:36
nixonixhttps://twitter.com/K_Sheldrick/status/142312069154134016801:38
LjLis it ethical to make fun of the idiotic covid-related shit someone is saying on a different channel?01:39
LjLi guess the answer is maybe01:39
nixonixim bad in ethics. quote?01:40
LjL<Joanna> I have asthma and don’t enjoy suffocating <Joanna> If I go into a store and someone starts yapping about masks I do a quick about face and take my money elsewhere. <Joanna> jeaye: you know what’s really funny is on the train when a masker starts coughing and a nearby masker jumps up and runs away in terror to another part of train :) <Joanna> But they are both wearing masks so they should feel safe... <izak> lts wear our mask because01:42
LjL it is safer than nothing. <Joanna> izak: it’s about as safe as using a chain link fence as a mosquito net :)01:42
LjLand i interjected with01:42
LjL<LjL> no, because masks are not full protection by any means01:42
LjL<LjL> if you think they fully protect you, you're a moron01:42
LjL<LjL> if you think they don't protect you at all, you're a moron01:42
nixonixi was thinking, those russian disinformation campaigns might have hurt their own vaccinations. not sure if they have, since very low percentage of russians knows english (according to wikipedia)01:45
nixonixwell, maybe they know more german, italy, french etc and follow their medias instead of anglo (but i doubt)01:47
nixonixitalian01:48
nixonixlingua italiana01:48
LjLi was about to mock you in finnish about it01:48
nixonixthose are hard for me01:48
LjLbut too bad, you preempted me before i could figure out how to say "isn't"01:48
LjLsuomi on maa ja kieli01:48
LjLitaly ei01:49
nixonixk later01:50
LjLnote to self: don't mock nixonix in finnish01:53
BrainstormUpdates for Ivory Coast: +243 cases (now 50893), +4 deaths (now 338) since 22 hours ago — Canada: +508 cases (now 1.4 million) since 23 hours ago01:59
BrainstormUpdates for France: +20962 cases (now 6.3 million), +41 deaths (now 112173) since 21 hours ago — Netherlands: +2450 cases (now 1.9 million), +8 deaths (now 17991) since 21 hours ago — United Kingdom: +74 deaths (now 130193) since 21 hours ago02:36
himesama"The Alliance for Securing Democracy is a bipartisan transatlantic national security advocacy group formed in July 2017 with the stated aim of countering efforts by Russia to undermine democratic institutions in the United States and Europe. As of 2021, it had expanded to combating China's United Front Work Department. The organization is chaired and run primarily by former senior United States intelligence and Stat02:37
himesamae Department officials."02:37
BrainstormNew from NPR: CNN Fires Three Employees For Coming To Work Unvaccinated: The memo was obtained by The Associated Press after its contents were first tweeted by CNN media reporter Oliver Darcy. CNN offered no details on the firings, or where the employees were based. → https://is.gd/VSkCjD02:39
BrainstormUpdates for Vietnam: +7047 cases (now 185057), +393 deaths (now 2720) since 21 hours ago03:01
himesamai can't make sense of this but https://www.dhs.gov/science-and-technology/sars-calculator03:17
himesamaand also they have a master question list which has lots of facts but i can't seem to find the most recent version again03:17
himesamai have it in my evince but my evince is behaving strangely not allowing me to go to top of page03:18
BrainstormNew from r/WorldNews: worldnews: New COVID-19 outbreaks in China raise doubts about 2022 Winter Olympics in Beijing → https://is.gd/83U10x03:21
himesamahttps://www.dhs.gov/sites/default/files/publications/mql_sars-cov-2_-_cleared_for_public_release_20210713.pdf03:21
himesamawhich is safer nose breathing or mouth breathing/03:27
himesamais this true?  "Transmission occurs primarily through respiratory droplets produced by talking, coughing and sneezing."03:29
BrainstormUpdates for Guadeloupe: +2696 cases (now 23821) since 2 days ago03:38
BrainstormNew from r/WorldNews: worldnews: Vaccine monopolies make cost of vaccinating the world against COVID at least 5 times more expensive than it could be → https://is.gd/4PrJcb03:42
BrainstormNew from r/WorldNews: worldnews: St. Vincent Prime Minister reportedly hospitalized after being attacked and “struck in the head” by anti-vaccine protesters → https://is.gd/ertU1Y03:53
BrainstormUpdates for Sint Maarten: +43 cases (now 2891) since a day ago04:40
BrainstormUpdates for France: +20267 cases (now 6.3 million), +42 deaths (now 112186) since 20 hours ago — United Kingdom: +22425 cases (now 6.0 million), +65 deaths (now 130215) since 20 hours ago — Netherlands: +2542 cases (now 1.9 million), +8 deaths (now 17993) since 20 hours ago — Canada: +1241 cases (now 1.4 million) since 20 hours ago05:05
BrainstormNew from r/WorldNews: worldnews: News-Medical.Net: Two monoclonal antibodies broadly neutralize SARS-CoV-2 variants of concern. → https://is.gd/34J0Y105:07
BrainstormNew from r/WorldNews: worldnews: Fauci: New, Resistant Variants Will Happen If Vaccinations Don’t Rise → https://is.gd/cQQ1Ma05:17
BrainstormUpdates for Thailand: +21379 cases (now 714684), +191 deaths (now 5854) since 21 hours ago05:30
BrainstormNew from The Indian Express: World: US Covid-19 cases reach six-month high, Florida grapples with surge → https://is.gd/B8Ln1U06:31
BrainstormNew from The Indian Express: World: CNN fires three employees for coming to work unvaccinated → https://is.gd/iI8Pgn06:53
BrainstormUpdates for Antigua and Barb.: +9 cases (now 1320) since a day ago07:10
BrainstormNew from The Indian Express: World: China seeks to control COVID-19 flare-up → https://is.gd/sb33IE07:24
BrainstormUpdates for Mexico: +21569 cases (now 2.9 million), +618 deaths (now 243165) since 23 hours ago — Tokyo, Japan: +5042 cases (now 236206), +1 deaths (now 2302) since 23 hours ago — Kansas, United States: +4187 cases (now 338312) since 23 hours ago — New York, United States: +3536 cases (now 2.2 million) since 23 hours ago07:34
alibabaii[m]hi07:35
BrainstormUpdates for Uzbekistan: +974 cases (now 134826) since 22 hours ago — Belgium: +1973 cases (now 1.1 million), +6 deaths (now 25264) since a day ago07:59
BrainstormUpdates for India: +44643 cases (now 31.9 million), +450 deaths (now 426610) since 15 hours ago08:37
BrainstormNew from The Indian Express: World: China sees highest daily coronavirus cases in current outbreak → https://is.gd/HlFfnt08:38
BrainstormNew from r/Coronavirus: Daily Discussion Thread | August 06, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/O02iui09:09
BrainstormNew from The Indian Express: World: S.African study shows J&J vaccine protects against death, co-lead investigator says → https://is.gd/iFX1Jh09:30
BrainstormNew from Virological.org: Latest topics: The molecular clock of variants of concern: The emergence of SARS-CoV-2 variants of concern is driven by episodic acceleration of the genomic rate of molecular evolution John Tay, Ashleigh F. Porter, Wytamma Wirth, and Sebastian Duchene*. Peter Doherty Institute for Infection and Immunity, University of [... want %more?] → https://is.gd/qTGtuo10:13
BrainstormNew from The Indian Express: World: China pledges 2 billion vaccines globally through year’s end → https://is.gd/3JWxuE10:24
BrainstormUpdates for Lithuania: +777 cases (now 285209) since a day ago10:41
BrainstormNew from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Comirnaty, COVID-19 mRNA vaccine (nucleoside-modified), COVID-19 virus infection, Date of authorisation: 21/12/2020, Revision: 10, Status: Authorised → https://is.gd/golaYG10:45
BrainstormUpdates for Philippines: +10529 cases (now 1.6 million), +246 deaths (now 28673) since a day ago — Germany: +3637 cases (now 3.8 million) since 23 hours ago11:06
BrainstormNew from r/WorldNews: worldnews: Top court rules France's Covid-19 'health pass' complies with constitution → https://is.gd/C2OQbv11:58
BrainstormUpdates for Guinea: +289 cases (now 26477), +5 deaths (now 243) since a day ago12:08
BrainstormNew from ScienceNews: What science tells us about reducing coronavirus spread from wind instruments: Performers struggled to find evidence that would free them from musical lockdown, so they partnered with researchers to get some answers. → https://is.gd/mFISY912:09
BrainstormNew from The Indian Express: World: Japan COVID cases hit 1 million as infections spread beyond Tokyo → https://is.gd/7DDqUh12:41
-RSSBot[LjLmatrix- Feed: Il saluto del Presidente del Consiglio Mario Draghi prima della pausa estiva ( https://www.governo.it/it/articolo/il-saluto-del-presidente-del-consiglio-mario-draghi-prima-della-pausa-estiva/17597 )12:52
BrainstormNew from Politico: Aid and development: UK’s COP26 president criticized for traveling without quarantine → https://is.gd/lQxTKt13:23
BrainstormUpdates for Malaysia: +20889 cases (now 1.2 million), +160 deaths (now 10179) since a day ago13:35
BrainstormUpdates for Nepal: +2430 cases (now 710509), +25 deaths (now 10019) since a day ago — Switzerland: +1167 cases (now 723968) since 23 hours ago14:37
BrainstormNew from r/Coronavirus: Coronavirus: United Airlines will require employees to be vaccinated against the coronavirus. → https://is.gd/6eGTfy14:58
BrainstormUpdates for Azerbaijan: +1242 cases (now 349316), +8 deaths (now 5051) since 18 hours ago15:02
BrainstormNew from Contagion Live: This Week in COVID-19 News: Is a Booster Dose Coming?: With the US federal government health agencies discussing plans for a booster dose for Americans and WHO’s call for a moratorium on these shots, a tale of two vaccine strategies is emerging. → https://is.gd/y0OyGy15:08
BrainstormNew from Contagion Live: Recommendations for HIV Screening: Recommendations for primary care physicians to help properly identify patients who should be tested for HIV, and an overview of available screening tests. → https://is.gd/loeOmU15:19
BrainstormUpdates for Belarus: +1295 cases (now 451740), +10 deaths (now 3513) since a day ago15:39
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: FDA expects to have Covid booster plan by early September; feds halt Novavax vaccine funding → https://is.gd/M07Xoy15:51
BrainstormUpdates for Bangladesh: +12606 cases (now 1.3 million), +248 deaths (now 22150) since a day ago16:04
BrainstormNew from r/WorldNews: worldnews: Intel agencies scour reams of genetic data from Wuhan lab in Covid origins hunt → https://is.gd/P3HjBr16:23
BrainstormNew from r/WorldNews: worldnews: United Airlines will require all U.S. employees to get Covid vaccines, a first for domestic carriers → https://is.gd/kM4cko16:33
BrainstormNew from NPR: California Will Require Vaccines For Workers In Health Care Facilities: Workers in health care facilities will be required to provide proof that they have been fully vaccinated against COVID-19, with exemptions only for religious or valid medical reasons. → https://is.gd/ayiCkc16:55
BrainstormNew from StatNews: As HIMSS approaches, plans for health tech’s biggest gathering are clashing with a need for caution: HIMSS was supposed to be a celebration of digital health's banner year. It's instead shaping up to be a microcosm of another distressing moment in the pandemic. → https://is.gd/lExrHY17:05
BrainstormUpdates for Germany: +2917 cases (now 3.8 million), +12 deaths (now 92257) since 23 hours ago17:06
BrainstormNew from Reddit (test): Friday 06 August 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://is.gd/gB01rX17:16
BrainstormNew from Contagion Live: us: Double Vaccinated Three Times Less Likely to Test Positive for COVID-19 → https://is.gd/j8AxGG17:26
BrainstormUpdates for Kosovo: +271 cases (now 109310) since 23 hours ago17:31
BrainstormNew from NPR: United Becomes First Major U.S. Airline To Require Employees Be Vaccinated: Citing "incredibly compelling" evidence that COVID-19 vaccines are safe and effective, United CEO Scott Kirby announced the policy change on Friday. It will affect the carrier's 67,000 U.S. employees. → https://is.gd/cyi80M17:48
BrainstormUpdates for United Kingdom: +31442 cases (now 6.0 million) since 15 hours ago — Italy: +6599 cases (now 4.4 million), +24 deaths (now 128187) since 23 hours ago18:08
BrainstormNew from Ars Technica: Science: GOP congressman gets COVID-19 after suing Pelosi over mask rule → https://is.gd/MFzpmm18:09
LjLlooks like the UK and Italy have both stopped... stopping growing18:10
de-factoso we have R-value plots?18:17
de-factohmm whats with UK? does it go up again?18:18
de-factohttp://offloop.net/covid19/?default=United%20Kingdom;Italy&byPopulation=yes&cumulative=no&miscType=Reff&leftTrim=40018:20
de-factolooks like in UK reproduction raised again since 2021-07-28 R ~ 0.73 and 2021-08-05 R ~ 1.0 hence dR/dt ~ (1.0 - 0.73)/8d ~ 0.03375/d ~ 1/30d18:22
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Lambda COVID variant "a potential threat to human society," researchers say → https://is.gd/Zqkb6m18:41
BrainstormNew from In The Pipeline: Viral Knots: The current pandemic has made everyone think a lot more about viruses than they ever had any desire to, but they’re a constant background to our lives – and to the lives of pretty much every living creature. Humans have their viruses, other mammals have theirs (with occasional catastrophic overlaps), and [... want %more?] → https://is.gd/Fih5b819:02
BrainstormUpdates for Sri Lanka: +2794 cases (now 324223) since 22 hours ago — North Macedonia: +325 cases (now 157251), +1 deaths (now 5502) since a day ago — Yemen: +27 cases (now 7131), +1 deaths (now 1384) since a day ago — Mali: +18 cases (now 14633) since 21 hours ago19:11
BrainstormNew from Contagion Live: The Delta Variant: What it Means for the Vaccinated and Unvaccinated: Recent breakthrough infections have experts looking closely at the true risks of the COVID-19 delta variant and how we can protect ourselves. → https://is.gd/WkyoJI19:13
BrainstormUpdates for Spain: +21561 cases (now 4.6 million), +75 deaths (now 82006) since a day ago — Canada: +24 deaths (now 26656) since 17 hours ago19:36
BrainstormNew from r/WorldNews: worldnews: Russia records about 463,000 excess deaths in pandemic -Reuters calculations → https://is.gd/h47oxf19:55
BrainstormNew from COVID19 Vaccine Tracker: Andy Becker: Bagheiat-allah University of Medical Sciences: COVID-19 Recombinant RBD Protein Vaccine → https://is.gd/7u1GtD20:06
rpifani dont see novavax20:07
nixonixold but big (feb): placebo group for Novavax’s vaccine in South Africa🇿🇦: people with prior #COVID19 infections appeared just as likely to get sick as people without prior infections20:19
nixonixhttps://twitter.com/drericding/status/135806535578513408320:19
nixonixThe good thing is that the Novavax vaccine was roughly equally ~50% effective (in South Africa 🇿🇦, higher elsewhere) against the virus regardless of past infection (denoted as serostatus positive or negative in the figure)20:20
nixonix.title https://www.theatlantic.com/science/archive/2020/10/single-tree-species-may-hold-key-coronavirus-vaccine/616792/20:22
Brainstormnixonix: From www.theatlantic.com: A COVID-19 Vaccine Could Rely on Rare Trees in Chile - The Atlantic20:22
rpifannot a good thing20:24
rpifanto destroy rare trees20:25
nixonixthey are growing those, if i recall. it was a while back i read the article, i thought you guys might be interested20:25
nixonixcultivating20:26
rpifanhm20:27
nixonixthere are some interesting trees, pacific yew for chemotherapeutic drugs, arrow poison in that tree in asia, then those in americas to stun fish. and sassafras for root beer (banned in usa nowdays i think, use of sassafras in it)20:32
nixonixand that tree they use for mdma, what was it again20:32
BrainstormUpdates for Albania: +149 cases (now 133591), +1 deaths (now 2458) since a day ago20:38
BrainstormNew from CIDRAP: COVID-19 Scan for Aug 06, 2021: COVID-19 antibodies after 7 months Long COVID in hospitalized patients → https://is.gd/S2FLoZ20:48
nixonixhttps://twitter.com/DrEricDing/status/142348372066574746020:50
nixonixhttps://twitter.com/DrEricDing/status/142348432675108454820:51
nixonix.title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716952/20:52
Brainstormnixonix: From www.ncbi.nlm.nih.gov: Possible modes of transmission of Novel Coronavirus SARS-CoV-2: a review20:52
nixonix"some of the other possible modes of transmission are being explored by the researchers, with some studies suggesting the viral spread through fecal-oral, conjunctival secretions, flatulence (farts)"20:53
OrTh0DoXAre there any studies being done on why a person still can get serious illness from COVID-19 even after 2 doeses of vaccine? 2nd dose was administered 5 months ago.20:54
LjLwhy? mainly because the new variants aren't really covered by the original vaccines20:54
OrTh0DoXNo. From what I know the person contracted is the Delta variant20:55
LjLwhat's "no" about that?20:55
LjLDelta is not covered by the current vaccines20:55
LjLthe antibodies elicited are much less effective than against the original variants20:55
LjLthere are certainly studies on *that*20:55
OrTh0DoXI see. even with 3rd booster shot is still futile?20:56
LjLnot necessarily, since the antibodies appear to skyrocket after a 3rd shot according to Pfizer. but the ideal thing would be a vaccine made specifically for Delta, which Pfizer is worked on20:56
LjLworking on*20:56
LjLModerna is working on a Beta vaccine, at least they have it on trial already, they're probably working on more too20:57
nixonixwaning antibodies and b-cell maturating stopping after the 2nd dose. for indian variant its evasiveness isnt close to SA variant, the efficacy drops only to around half if its recent vaccination (i use inverse ratio, the share that gets infection)20:57
LjLbut since the bad variants have similar mutations, it's possible the Beta vaccine will be effective against Delta too20:57
OrTh0DoXgreat to know! And I hope these studies will include the Delta+ variant20:59
BrainstormUpdates for Aruba: +262 cases (now 12262) since a day ago21:03
LjLde-facto, hmm does https://cov2tree.org/ offer anything that the other friendly sites of ours don't? because then i'll add it, but otherwise its interface seems slow and clunky in comparison to the others21:04
ArsaneritI read something about nasal vaccines, are those somehow special?21:04
LjLArsanerit, current vaccines probably don't protect the upper airways, which may drive continued transmission21:05
LjLthere is some sort of... not quite an immune barrier, but something like that between the main immune system and the mucosal system21:05
ArsaneritThat's why there's still asymptomatic infections with the current vaccines, in particular with delta?21:06
nixonixwhat was known about pfizers and modernas vacc afficacy vs SA variant?21:06
ArsaneritCan we expect those better (?) nasal vaccines any time soon?21:06
LjLArsanerit, i think it's a combination of that, and Delta simply evading the vaccines21:07
Arsaneritapparently the Moderna vaccine is called Spikevax®.21:07
Arsaneritenwiki says Comirnaty® is 79% effective against asymptomatic infection for Delta and 75% for Beta.21:09
LjLnixonix, https://investors.modernatx.com/news-releases/news-release-details/moderna-covid-19-vaccine-retains-neutralizing-activity-against  https://investors.modernatx.com/news-releases/news-release-details/moderna-covid-19-vaccine-retains-neutralizing-activity-against  https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-confirm-high-efficacy-and-no-serious (CI 53% to 100%)  https://www.medrxiv.org/content/10.1101/2021.04.06.21254882v21:09
LjL2 (odds ratio 8:1) https://www.nejm.org/doi/full/10.1056/NEJMc2104974 (75% efficacy)21:09
LjLArsanerit, they are not better, they are complementary21:09
BrainstormNew from WebMD: Dangerous Price of COVID Rules for Women, Children in Africa: COVID-19  safety responses have had harmful, and life-threating, effects for women and children across the continent. → https://is.gd/ahYM7E21:09
ArsaneritLjL: ah, ok.  When can we expect those?21:10
LjLArsanerit, i don't know. India is already using one21:10
ArsaneritIs it helping (in India)?21:13
LjLi don't know21:13
de-factoLjL, its pretty neat because of the zooming feature, otherwise it would be difficult to browse 1M+ sequences21:22
de-factohttps://twitter.com/firefoxx66/status/141606005990225510421:22
de-factohttps://twitter.com/theosanderson/status/141207871455743590421:22
de-factohttps://github.com/theosanderson/taxodium21:22
nixonixif we knew with high confidence efficacy for symptomatic infection and for pcr positive, the difference would be asymptomatic infections (considering differencies in age groups, waning etc)21:23
de-factohttp://hgdownload.soe.ucsc.edu/goldenPath/wuhCor1/UShER_SARS-CoV-2/21:23
nixonixbut theres also that presymptomatic shedding period, and with indian variant it's share seems to be bigger21:23
nixonixhttps://twitter.com/jburnmurdoch/status/141342309588134707721:24
de-factoLjL, also it got very powerful search functions, i kinda like https://cov2tree.org/21:25
LjLde-facto, ah it's specifically about public sequences21:25
nixonixover 200M identified cases, so it has 0.5% of them21:26
LjLit takes a *long* time to load21:27
nixonixhalf british and 5% danish?21:27
nixonixhttps://twitter.com/imgrund/status/141908060922642841721:29
BrainstormNew from StatNews: Biotech: STAT+: Adagio raises $300 million in IPO, looks to advance Covid-19 antibody therapy → https://is.gd/ofBmoQ21:30
de-factofor me it loads in 8s21:31
de-factoimho quite impressive for displaying 1,254,751 sequences from INSDC, COG-UK and CNCB21:31
-RSSBot[LjLmatrix- Recent Commits to links:master: Add Cov2Tree ( https://github.com/ljl-covid/links/commit/78b2ced6ac6eacb85887b5e072846b0dee2abc78 )21:33
de-factoalso note the Genbank links, easy to get the full sequence that way21:33
de-factoi guess you noticed mousewheelzoom etc21:34
nixonixdoesnt show anything, possibly because disabled webgl - but i checked that around half are british indeed. only a few from denmark though (and finland or sweden)21:36
-RSSBot[LjLmatrix- Recent Commits to links:master: Add source of Cov2Tree data ( https://github.com/ljl-covid/links/commit/934a9f6f49736e8ef195167c426a85e9972a1b79 )21:38
BrainstormUpdates for Burundi: +369 cases (now 8088) since 16 hours ago — France: +44 deaths (now 112214) since 23 hours ago21:40
BrainstormNew from https://covid19.specops.network : ljl-covid: Add source of Cov2Tree data → https://is.gd/q546HE21:41
nixonixthat mAb above, targets conserved epitope of RBD which is good. this is sub-q so they can be used that way too (but these are affected by mutations of indian variant):21:45
nixonix.title https://www.nejm.org/doi/full/10.1056/NEJMoa2109682?query=featured_home21:45
Brainstormnixonix: From www.nejm.org: Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 | NEJM21:45
nixonixaround 3% of population apparently immunosuppressed in usa. those new variants seem to be emerging often from high HIV prevalence areas (not sure how it is in uk though), maybe from in-host evolution in immunocompromised21:51
nixonix"The recent demonstration of the use of combination monoclonal antibodies for preventing SARS-CoV-2 acquisition in nursing homes and home settings suggests that passive antibody prophylaxis may be another approach for immunosuppressed patients who do not have an adequate immune response to vaccination or for patients and their family members with21:51
nixonixhigh-risk exposure21:51
nixonixalthough its like 500-2k per pop. third dose of vacc should help (if its allowed)21:52
nixonixwell according to wiki, india and brazil arent that high hiv prevalence countries. or even brazil21:54
-RSSBot[LjLmatrix- Recent Commits to links:master: Removing Google&#39;s tracker, which doesn&#39;t appear to exist as such anymore ( https://github.com/ljl-covid/links/commit/8e3e96e6028f93cd67a33e6d5052fc6c22188177 )21:58
de-factohmm would monoclonal antibodies not produce an absolutely static selection, e.g. unable to follow antigenic due to lack of any feedback, thereby possibly give rise to new variants if the pathogen can escape the host treated before its neutralized?21:58
de-factoLjL, this https://news.google.com/covid19/map ?22:00
LjLde-facto, no it was a different address, i'll add that one22:01
de-factoi mean was it that functionality? i dont remember the previous one22:02
LjLi guess22:02
BrainstormNew from WebMD: New Biomaterial Vaccines Aim to Ward Off Future Pandemic Threats: Scientists are banking on the idea the structure of a future pathogen to threaten human health will be like the ones they already know about as they design next-generation vaccines. → https://is.gd/JzNqrF22:02
-RSSBot[LjLmatrix- Recent Commits to links:master: Removing CovidStat, as it redirects to an empty website ( https://github.com/ljl-covid/links/commit/8e6c8ad23cfddac03b8608d14a84db3b6d40517f )22:03
nixonixmoderna: Variant-specific booster candidates: mRNA-1273.351 & mRNA-1273.617 (new)    III. Multi-valent platform: mRNA-1273.211 & mRNA-1273.213 (new)22:03
nixonixWe believe that increased force of infection resulting from Delta, non-pharmaceutical intervention (NPI) fatigue, and seasonal effects (moving indoors) will lead to an increase of breakthrough infections in vaccinated individuals22:03
nixonixWhile we see durable Phase 3 efficacy through 6 months, we expect neutralizing titers will continue to wane and eventually impact vaccine efficacy   Given this intersection, we believe dose 3 booster will likely be necessary prior to the winter season22:03
LjLde-facto, this is also sourced mainly from Wikipedia, the old was too22:04
nixonix.title https://investors.modernatx.com/static-files/c43de312-8273-4394-9a58-a7fc7d5ed09822:04
Brainstormnixonix: From investors.modernatx.com: Moderna 2Q21 Earnings Call (Chasen Richter)22:04
de-factoLjL, hmm weird their github still exists but seems somewhat abandoned, so maybe their domain expired? https://github.com/COVID19-SARS-CoV-2/web-covid-api22:07
LjLupdated very long ago22:07
de-factooh wow nixonix nice find22:07
-RSSBot[LjLmatrix- Recent Commits to links:master: Add new address for Google tracker ( https://github.com/ljl-covid/links/commit/0b851607e71d3f4407d3f0cd3c48ea8447a04f17 )22:08
nixonix.title https://investors.modernatx.com/news-releases/news-release-details/moderna-reports-second-quarter-fiscal-year-2021-financial/22:11
Brainstormnixonix: From investors.modernatx.com: Moderna Reports Second Quarter Fiscal Year 2021 Financial Results and Provides Business Updates | Moderna, Inc.22:11
nixonixWe are also in the process of developing a booster tailored to the Delta variant (mRNA-1273.617), and anticipate developing a multivalent booster—referred to as mRNA-1273.213—that combines mRNA-1273.617 with another COVID-19 candidate.22:11
nixonixCMV vaccine (mRNA-1647): Our vaccine against cytomegalovirus, or CMV (mRNA-1647) is a vaccine combining six mRNAs in a single vial, which encode for two antigens located on the surface of CMV: five mRNAs encoding the subunits that form the membrane-bound pentamer complex and one mRNA encoding the full-length membrane-bound glycoprotein B (gB)22:11
nixonixthey have other vaccines coming too https://www.marketwatch.com/investing/stock/mrna/SecArticle?guid=1513986822:12
-RSSBot[LjLmatrix- Recent Commits to links:master: Remove duplicate Bing tracker entry ( https://github.com/ljl-covid/links/commit/a7e483512469bb5e5001bf4a7120acaa9ae0ead9 )22:13
-RSSBot[LjLmatrix- Recent Commits to links:master: Remove Plague.com, which doesn&#39;t respond anymore ( https://github.com/ljl-covid/links/commit/c19f144e6d06edf03c296abf662f6258e5221081 )22:18
nixonixtheres a vaccine candidate called ufovax. i considered using it as a nick, but youdve thought its just silly idea22:24
nixonix.title https://emedicine.medscape.com/article/2500139-overview22:24
Brainstormnixonix: From emedicine.medscape.com: COVID-19 Vaccines: Overview, mRNA Vaccines, Viral Vector Vaccines22:24
BrainstormNew from CIDRAP: US reaches 50% fully vaccinated against COVID: Lisa Schnirring | News Editor | CIDRAP News Aug 06, 2021 In other developments, one new study found vaccination provides better protection than previous COVID-19 infection and another high protection against hospitalization in older age groups. → https://is.gd/oufMYo22:44
nixonixmoderna: ≥4 months after dose 2** 92.4% (84.3, 96.8)  -  ** To earliest of study discontinuation, PDV/unblinding, or data cutoff date of 3/26/2021, longest follow up to 241 days22:47
de-factoi like their approach to put multiple s-protein signatures in one update shot22:53
LjLModerna?22:59
nixonixi like their CMV vaccine23:03
nixonixanyways, while those 4+ month results look strong, it was pre 617.2, and the problem with pfizer is especially over 60 yo, which are probably small share of modernas trial. hopefully uk releases more data on both soon23:05
ArsaneritSpikevax®23:12
LjLyou know you don't really have to include the ®23:13
nixonixhave they compared ab titers between pfizer and moderna? when they are very similar but moderna has 100 Mcg and pfizer 30, does moderna produce higher titers on average?23:17
LjLhave you seen in their financial report that they kind of assume they can use 50 Mcg in the future?23:19
nixonixmoderna has tested half doses for 3rd dose - and if i recall also for 2nd or even 1st in the past. pfizer induced less myo/pericarditis than moderna, so it would be better for 11-15 yo23:19
nixonixand younger kids have smaller doses anyway23:19
nixonixyeah, its prob way to go, and enough23:19
LjLinteresting, the spotlight on myocarditis was basically just on Pfizer23:20
nixonixhttps://twitter.com/itosettiMD_MBA/status/142360042956956467223:20
nixonixi dont remember what they had in those tables, but i saw that tweet, i guess its true23:21
BrainstormNew from COVID Zotero group: Excess Deaths Associated with COVID-19: Type Web Page URL https://www.cdc.gov/nchs/nvss/vsrr/covid19/excess_deaths.htm Date 2021-08-05T01:32:14Z Accessed 2021-08-06 21:21:17 Language en-us Abstract Figures present excess deaths associated with COVID-19 at the national and state levels. → https://is.gd/h8vtzP23:23
ArsaneritI know I don't have to23:27
BrainstormNew from COVID Zotero group: Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy: Type Journal Article Author Giulia Giordano Author Franco Blanchini Author Raffaele Bruno Author Patrizio Colaneri Author Alessandro Di Filippo Author Angela Di Matteo Author Marta Colaneri URL [... want %more?] → https://is.gd/i3mwhY23:34
LjLZotero has an issue when adding "things that aren't papers" that in theory it supports "web pages", but in practice 1) if those pages *link to* studies, apparently, you must select one of the linked study and you can't just add the page itself 2) sometimes it just doesn't like a given webpage, maybe it can't parse it, i dunno, and then you can't add it23:36
LjLi think it can't replace the github page, although it may be better for a larger number of papers23:36
nixonixaccording to ons survey, not all regions of uk or even england turned down at the same time (as was pretty much the case on daily cases). 6/9 regions of england23:47
nixonix.title https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/6august202123:47
Brainstormnixonix: From www.ons.gov.uk: Coronavirus (COVID-19) Infection Survey, UK - Office for National Statistics23:47
nixonixuk been on kinda plateau for awhile now, going up and down a bit23:48
nixonixah and there was age group graphs too, the peak was on 17 yo on most regions. northern ireland was 13-14 yo i think. ideas whys that? here the top spreaders have been 18-24 lately, in bar age23:51
nixonixis it 18 in uk or 16 something, pub age?23:51
nixonix.title https://www.medscape.com/viewarticle/95448123:55
Brainstormnixonix: From www.medscape.com: Adjunctive Thiamine in Critically Ill COVID-19 Patients23:55
nixonixThere was significant association between thiamine use with in-hospital mortality (OR = 0.39; 95% CI 0.19–0.78; P value = 0.008) as well as the 30-day mortality (OR = 0.37; 95% CI 0.18–0.78; P value = 0.009). Moreover, patients who received thiamine as an adjunctive therapy were less likely to have thrombosis during ICU stay [OR (95% CI) 0.1923:56
nixonix(0.04–0.88), P value = 0.03]23:56
nixonixmaybe ill start typing with bold from now on...23:57
TurboTechAfternoon23:58

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