libera/##covid-19/ Saturday, 2021-08-14

nixonixits viral vasculitis, so any organ can take damage00:02
nixonixone of the several possible mechanisms for brain damage too. apparently neurotropism is rarish00:03
LjLJbwncster, the US seems like a bit of a "every tiny entity makes its own rules" place00:03
Jbwncsterhttps://www.wral.com/coronavirus/masks-required-again-in-raleigh-starting-friday-night/19823970/00:04
JbwncsterLjL: I wish the feds had more power00:04
nixonixits inteesting to watch during this epidemic, how in several countries local governing bodies have more or less to say over central government. here too, currently region governing offices deciding on event and gathering restrictions, that got several ministers angry00:05
JbwncsterThe uk?00:06
JbwncsterCanada?00:06
nixonixthey have the power over them, but the government somehow took the power over restaurant restrictions from them00:06
nixonixfinland00:06
JbwncsterAh00:06
nixonix(cant remember if italy was a federation or not)00:06
JbwncsterWell states rights are a thing here00:06
JbwncsterIt annoys me00:06
JbwncsterStates shouldn’t have as many rights as they do00:06
nixonixmaybe, but that probably cant be changed in usa00:07
LjLnixonix, italy is not a federation, but healthcare-wise, it almost is. a bit of a strange (and probably mostly detrimental) reform from a few years ago.00:07
JbwncsterIt could but it would be hard00:07
JbwncsterDoesn’t Italy have countries within a country00:07
JbwncsterLike Russia but not as weird00:07
JbwncsterTuscany has a president00:08
nixonix.title https://www.nytimes.com/2021/08/05/world/san-marino-italy-vaccines.html00:08
Brainstormnixonix: From www.nytimes.com: As Italian vaccine passports come into force, tiny San Marino is left isolated. - The New York Times00:08
JbwncsterIs San Marino anti vax?00:08
nixonix.title https://www.theguardian.com/world/2021/may/19/we-booked-straight-away-first-covid-vaccine-tourists-arrive-in-san-marino00:08
Brainstormnixonix: From www.theguardian.com: ‘We booked straight away’: first Covid vaccine tourists arrive in San Marino | Coronavirus | The Guardian00:08
nixonixno, they are offering fifty if you take a russian jab00:08
Jbwncster50€?00:09
nixonixi guess00:09
JbwncsterNice00:09
JbwncsterMy state gave away 1 million to 3 people in a vaccine lottery00:10
JbwncsterThis sunmer00:10
JbwncsterSummer00:10
nixonix.title https://www.news-medical.net/news/20210810/Natural-vs-vaccine-induced-COVID-19-immunity.aspx00:11
Brainstormnixonix: From www.news-medical.net: Natural vs. vaccine-induced COVID-19 immunity00:11
LjLi know a few americans who think the federal government has already been taking away too many state rights, so i don't know if you'd find a momentum there00:11
LjLJbwncster, San Marino vaccinated its entire population with Sputnik V much quicker than Italy00:11
nixonixIgM+ B-cells with cross-reactivity are also found in some people, whereas the IgG antibodies are typically specific to the SARS-CoV-200:12
nixonixsince ljl doesnt correct my joke, i have to: you need to pay 50 for the russian vax00:13
LjLand for three days of stay, i think00:14
LjLdoesn't seem like such a bad deal, except for the vaccine00:14
LjLbut italians are apparently excluded, so they can get fucked00:14
nixonixyou noticed the problem, in that article, with non-certified vaccine use?00:15
nixonixjesus christ, uk and canada again. why do they always think im from either00:18
LjL"IgG and IgA titers rise following the class-switching of B cells after the early IgM response. IgG antibodies remain stable for months or years. IgG titers often decline at rapid or slow rates depending on how high they rose, the subtypes, and the involvement of short- and long-lived plasma cells in the immune response."00:18
LjLi suspect one of these IgG was supposed to be IgA...?00:18
nixonixid prefer to be mistaken as australian. i like their slang terms00:18
JbwncsterBetter than Russian00:18
JbwncsterOr Swedish00:19
LjLnixonix, not certifying vaccines used in large portions of the world as valid for travel is bullshit in my opinion00:19
LjLthere's very little science and a whole lot of politics in that00:20
LjLi wouldn't love to be getting Sputnik V, but i also don't think the EMA ever had any intention of certifying it (except perhaps when AZ was being "problematic" and we weren't getting enough Pfizer)00:20
nixonixit was strangely put, but i dont think they meant IgA instead of IgG. there are different types of b-cells producing IgG, plasma cells for that circulating ab thats responsible for those high levels during the first weeks or months, then b-cells in GCs that will activete on reinfection with delay of 5 days or so00:21
LjLbut then it leaves the fate of IgA hanging00:22
nixonixidk, a lot is open currently about the reduction of spreading. these good vaccines protection wanes faster than expected, infection-wise, but those non-western are just bad (meaning indian variant for all those)00:23
nixonixso when they refuse to accept non-certified vaccines, a bit more must be known about the difference, preventing spreading over the borders. and for vaccine passports within countries too00:24
* Jbwncster gives LjL the sinovac00:24
LjLnixonix, i think it's clear enough that spreading is not prevented even by vaccines that ARE approved, that if we were objective about it, we'd just not allow travel00:26
nixonixIgA just wanes faster than IgG, circulating type. idk if there are germinal center IgA b-cells. also the role of it for some things is currently uncertain. i wrote or pasted something about it lately00:26
LjLsaying we allow it with certified vaccines, even though we *know* they don't stop the infection, but don't allow it with "uncertified" vaccines, even though for what we know Sputnik may still be at 90%, is a bit hypocritical00:26
nixonixyeah but its very recent and unconfirmed information, the protection for infections waning so fast. after confirming a lot of things must be reconsidered00:27
nixonixhow to get the best possible result, while not as good as was hoped00:27
nixonix(when in reality they just fuck it up in several ways)00:27
LjLalso from your article "The republic, which is not an EU member, signed a deal with Russia in February after doses of other vaccines it had been expecting to receive from Italy via the bloc’s procurement programme did not arrive."00:28
LjLso San Marino may have been cunning and everything with their "travel plan", but they also were disappointed - like i think most of the rest of us - when vaccines weren't coming as promised00:28
LjLthe only difference is they weren't bound to the EU procurement agreements00:28
nixonixany eu country could order sputnik if it wants, and use it00:29
nixonixsome politicians considered it in germany and finland during the winter00:29
nixonixhere those supporting our ex presidents idea were mostly antivaxers, though...00:29
nixonixanyway, in uk they used couple of large batches of indian made az (covishield or something i think), that is not eu approved. i might have claimed here, they didnt know which batch their jab was from, but later learned they got the batch number00:31
nixonixbut theres been problem, is it eu approved or not. not sure of the status, eu-wide. some countries might have approved it, but not sure if the whole eu00:32
nixonixmaybe they did, because i think they approved, for travelling, some chinese vaccine that was in WHOs aproved list00:32
LjLnixonix, China was doing the same nonsense, only allowing people into China if vaccinated with *their* vax00:36
LjLit's apparent it's a geopolitical thing00:36
LjLif you get jabbed by China then you can't travel around Europe, if you get vaccinated by Europe then you can't travel in China00:36
nixonixi saw some eu travelling approved list with one or two chinese, not sure if vaccine was there. but just recommendation. maybe commision00:36
nixonix.title https://www.schengenvisainfo.com/news/poland-recognises-ema-approved-covid-19-vaccines-only/00:36
Brainstormnixonix: From www.schengenvisainfo.com: Poland Recognises EMA-Approved COVID-19 Vaccines Only - SchengenVisaInfo.com00:36
nixonixyeah, they were saying people outside of china that get their jab if you want to travel to china. in singapore was it, or thailand or something00:37
nixonixcertificate qr checking app, google: COVID Certificate  Federal Office of Public Health FOPH00:43
nixonix.title https://ec.europa.eu/health/ehealth/covid-19_en00:44
Brainstormnixonix: From ec.europa.eu: eHealth and COVID-19 | Public Health00:44
twomooni'm tired of hearing 'jab/jabbed' but i guess it's shorter than vaccinated00:45
nixonixjson schema in the link00:46
LjLnixonix, you can see it on github too00:47
LjL%links eu covid certificate00:47
BrainstormLjL, https://github.com/ehn-dcc-development/ (European eHealth network - digital covid certificate coordination) and the https://github.com/eu-digital-green-certificates (Official GitHub Organization of the EU Digital COVID Certificates (EUDCC) project, previously known as the EU Digital Green Certificates (DGC)) set the standards and provide reference implementations for the [... want %more?]00:47
nixonix.title https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/covid-19-vaccines  includes vax you have never heard the name before00:48
Brainstormnixonix: From www.ema.europa.eu: COVID-19 vaccines | European Medicines Agency00:48
nixonix"vero cell" is a chinese one i think, that is sometimes called that00:49
LjLi dunno, vero cell is a common cell culture, is a vaccine called that?00:53
LjLi think both of the big chinese vaccines are inactivated virus anyway00:53
LjL%vax vero00:54
BrainstormLjL, no such vaccine found. Try checking https://covidvax.org00:54
LjL%vax sinopharm00:54
BrainstormLjL, Inactivated is a Inactivated virus vaccine developed in China by Beijing Institute of BioProducts (Sinopharm) + Chinese Center for Disease Control and Prevention, which started distribution initially on December 2020 → https://covidvax.org/covid19-vaccine/BeijingInstBio [... want %more?]00:54
LjL%vax coronavac00:54
BrainstormLjL, no such vaccine found. Try checking https://covidvax.org00:54
LjL%vax sinovac00:54
BrainstormLjL, Inactivated + alum CoronaVac is a Inactivated virus vaccine developed in China + Brazil by Sinovac + Instituto Butatan, which started distribution initially on December 2020 → https://covidvax.org/covid19-vaccine/Sinovac [... want %more?]00:54
LjL%vax NVX-CoV237300:54
BrainstormLjL, no such vaccine found. Try checking https://covidvax.org00:54
LjL%vax Vidprevtyn00:54
BrainstormLjL, no such vaccine found. Try checking https://covidvax.org00:54
LjLmaybe the EMA is just making up names00:54
nixonixno, it was finlands approved for travelling vaxes. naturally they accepted all them chinese etc...00:55
LjLlol, italian headline: "Vidprevtyn il vaccino made in Italy", you look it up, it's made by Sanofi-Pasteur00:55
nixonixi tried to google: "spikevax" "ufovax" - i got only two links. then i added "picovax", zero links00:56
nixonixso we dont have a list with all the vaccine names anywhere!00:56
nixonix(i had seen vidprevtyn before somewhere, once or twice)00:57
LjLyeah i'm not sure Vidprevtyn is even listed at https://covidvax.org/covid19-vaccines-full-list at all... although it lists *two* Sanofi-Pasteur vaccines. how many are they making? maybe they should try making one that works, since so far, they have failed ;(00:57
nixonixyeah, its just another name for that sanofis failed vax, or maybe for updated version00:58
bernard__why did .se had less cases than .uk?00:58
LjLi wish there was a vaccine database with an actual API. so far i'm scraping covidvax and i'm not really looking forward to scraping more things00:58
nixonixwith gsk's AS03 squalene adjuvant, unless they changed it, but i doubt00:58
nixonixthat was used in pandemrix00:58
nixonixthat narcolepsy vax00:59
LjLbernard__, because having the exact same number of cases would be exceedingly unlikely, and having more cases would have been roughly equally likely (per capita, anyway)00:59
LjLbut jokes aside, Sweden had *more* COVID cases per capita than the UK00:59
nixonixbut it maybe good for b-cell maturation. its possible that some day we replace those fast waning mrna vaccines with that or some other adjuvanted vax00:59
LjLif you just look at absolute numbers, well... that makes no sense, obviously00:59
nixonixtheres no vaccine called karatevax01:01
LjLkungfluvax? that was one of the uncouth names for COVID that caused scandal01:03
nixonixsanofi's vax uses flublok technology (i think it was unadjuvanted, and pandemrix with squalene beat it in ab maturation comparison, in some paper)01:04
LjLi think you're just making up words now01:06
dTal"flublok technology" definitely sounds fictional01:12
dTalroughly Doctor Who cheesiness level01:12
whytekthis pandemic is bigger on the inside.01:13
dTalor like something out of a toothpaste advertisement01:13
whytekBut come to think of it.. We should probably be putting more effort into building a tardis than a vaccine.01:14
whytekThen just go back and stop the virus.01:14
whytekeasy peasy.01:15
dTalTardii are grown, silly01:15
whytekhah! you just outed yourself as a true fan of the doctor.01:15
dTalwould a true fan murder that plural so luridly01:16
nixonixbbc destroyed the original tapes, 97 episodes lost forever01:20
nixonix(never seen the series, old or new)01:20
LjL:(01:20
LjLcopyright strikes again, i guess01:21
nixonixwhy did they destroy them? finnish wiki doesnt say01:21
LjLprobably just overwrote them01:21
LjL"Between 1967 and 1978 the BBC routinely deleted archive programmes, for various practical reasons (lack of space, scarcity of materials, a lack of rebroadcast rights)."01:22
nixonixthats crazy. well maybe they were quickly done trash entertainment, they thought nobody would miss01:22
LjLuncited but also "This happened for several reasons, primarily the belief that there was no practical value to its retention." - such shortsightedness01:24
LjLit seems they literally thought that01:24
dTalit does seem bizarre, that you'd spend all that money and go to all that effort just to produce a half hour of TV that you air exactly once and then never show again and destroy the only tap01:27
dTalbut I guess they saw it more like live theatre than like making movies01:28
LjLdTal, maybe it was still an era of transition from the concept that TV was almost necessarily live, once and it's gone01:28
LjLalso, recordings were physically quite large, i guess01:28
dTalI forgive the BBC more for losing some episodes of a low budget scifi series than NASA for literally losing the raw moon footage01:30
LjLlol, they did?01:30
nixonix"North Korea is believed to be confining violators of quarantine rules in “total control zones.” If you enter one of these camps of lifetime imprisonment, you can never rejoin society01:30
LjLsome would say NASA lost a high budget scifi sceries01:30
dTalthey really did. cue the conspiracy theories. All we have now are recordings of the TV broadcast01:30
nixonixdailynk, most of its stuff isnt probably true01:30
dTalBut the original telemetry from the moon, that was not kept.01:31
LjLwell, i can't complain, i repeatedly rewrote my valuable C64 BASIC programs onto the same portion of tape until i lost them01:32
LjL"In the early 1980s, NASA's Landsat program was facing a severe data tape shortage and it is likely the tapes were erased and reused at this time.[2]"01:33
LjLthe Great Eights Data Tape Shortage. it hit all of us *nod*01:33
dTalstill though. Imagine finding that tape, labeled "moon footage (original) (only copy)" and going "phew, finally somewhere to store my ascii erotica"01:35
LjL"The SSTV signal was recorded on telemetry data tapes mostly as a backup in case the real-time conversion and broadcast around the world failed. Since the real-time broadcast conversion worked, and was widely recorded on both videotape and film, the backup video was not deemed important at the time.[1]"01:36
LjLsince the camrip worked, and the result was widely available on bittorrent, the film was destroyed01:36
dTalright, so the same mentality as Doctor Who. Live broadcast worked, who needs the tapes?01:37
twomoonlol01:38
LjL"Mike Inchalik, president of Lowry Digital, mentioned that his company would only restore the video and would not remove defects (such as reflections that looked like flag poles).[1]" :P01:38
dTal...how can you restore a video without removing the defects01:38
dTallazy bum01:39
LjLdTal, "See also: British television Apollo 11 coverage, much of which is also missing"01:39
LjL"All three UK television channels, BBC1, BBC2 and ITV, provided extensive coverage. Most of the footage covering the event from a British perspective has now been wiped or lost.[1][2]"01:39
dTalwell to be fair that must have seemed pretty boring01:40
dTalif they wiped it to make room for doctor who that's a fair trade I reckon01:40
nixonixanother moon landing? come on, this is ridiculous!01:43
nixonix"With each successive moon landing after Apollo 11, the public paid less and less attention, and the television networks provided less coverage, with the exception of Apollo 13’s dramatic brush with disaster01:43
nixonix.title https://www.sciencehistory.org/distillations/magazine/waning-interest01:44
Brainstormnixonix: From www.sciencehistory.org: Waning Interest | Science History Institute01:44
nixonixthey should do it as a reality tv. mike the situation, some kashardians, those from chelsey shore or what it was01:46
nixonixi think they are planning just that for mars01:47
nixonixthats why mars is big. not that there would be anything interesting there01:47
rpifantheres elon musk01:48
LjLhttps://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00482-5/fulltext  "We identified two cases of a potential vaccine-escape variant from the B.1.621 lineage."01:52
nixonixi wonder when this is mostly over, if those erics keep tweeting01:54
nixonixor if they go to instagram01:54
LjLthey might be dead by the time this is mostly over01:54
nixonixbut while im joking, they are superstars of this era, that everybody knows. i wonder if people are still interested or if it will be like those moon missions01:55
nixonixbtw, topol just tweeted that lancet link01:57
LjLi know, i got it from ##covid-ticker.01:58
LjLit's honestly not a topic i'm super-interested in except for the fact it's threatening to kill us01:58
LjLmaybe that explains why you go into some details that seem to much of a headache for me. or i need more theanine.01:58
nixonix.title https://www.ft.com/content/c21e2053-0373-4b8e-80b7-fad10f235604   https://archive.is/1GqZd02:03
Brainstormnixonix: From www.ft.com: Become an FT subscriber to read | Financial Times02:03
nixonix* First to vaccinate and first to party, Israel now mulls lockdowns02:04
nixonix.title https://twitter.com/DFisman/status/142617681062730547402:09
Brainstormnixonix: From twitter.com: David Fisman (@DFisman): "Sharing this via twitter because I think it's in the public interest to know: we now have enough delta cases in kids, and enough pediatric hospitalizations in Ontario, that [...]02:09
pwr22Oh I missed the Doctor Who chatter02:09
pwr22I wonder if we can reverse the polarity of the neutron flow in covid?02:09
nixonix.title https://twitter.com/DrZoeHyde/status/1426212404124286980  compared to 1.1.702:11
Brainstormnixonix: From twitter.com: Dr Zoë Hyde (@DrZoeHyde): "Yes, that's correct. However, to put these numbers in context, a previous study from the UK found that about 1% of children who *test positive* will be hospitalised. But [...]02:11
nixonixthey got similar ratios for adults in canada before, that ive linked here02:12
nixonixeg finnish healtcare officials dismissed those, and have been saying they think or are not seeing indian variant being more severe02:13
LjLnixonix, i'm lost, here SGFT means likely-Delta or likely-nonDelta?02:13
LjLsince it would have originally meant Alpha02:13
nixonixbut they dont know the prevalence of infections, and its anecdotal anyway, compared to studies, were they right or not02:14
nixonixim too tired, what was that about?02:15
LjLyour tweet02:15
LjLthe table in it02:16
nixonixah that table, ill have look see02:16
nixonixoh yeah, s-gene negative means it has that dropout that kent variant has02:17
nixonixso if its s-gene positive, its something else02:17
LjLbut then it makes no sense02:17
LjLbecause "target failure" would mean s-gene negative, no?02:17
LjLwhich would mean kent variant02:17
LjLsurely kent variant isn't worse than delta02:17
LjLand the reverse is what they're saying02:17
LjLi dunno02:17
LjLor is that a "let's remember Alpha" table?02:18
LjL%title https://www.bmj.com/content/373/bmj.n1412 uhm based on the study title i guess maybe it is02:18
BrainstormLjL: From www.bmj.com: Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis | The BMJ02:18
nixonixtested between 23 November 2020 and 31 January 202102:19
nixonixso kent was HR 1.5x older 614G lines02:20
nixonixbut for kids about the same02:20
nixonixim pretty good just guessing acronymes, idk why, but it was supposed to be SGTF, not SGFT02:23
nixonixnow i never know if had guessed, bummer02:23
Win7ineso when is the variant adapted mRNA vaccine surfacing? I understood the very advantage of this was its flexibility and adaptibility. Still all helathsectors are pushing old COVID19 inocculation whereas we are at the end of 2021 ...02:25
nixonix.title https://twitter.com/DrEricDing/status/142103082253931724902:27
Brainstormnixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "14) is the #DeltaVariant more severe of a strain? Yes. The CDC deck highlights 3 studies showing higher hospitalization risk and deaths. But it actually missed 2 other [...]02:27
nixonix.title https://www.ndtv.com/world-news/no-need-yet-to-adapt-pfizer-vaccine-for-covid-variants-biontech-chief-250651202:30
Brainstormnixonix: From www.ndtv.com: No Need Yet To Adapt Pfizer Vaccine For Covid Variants: BioNTech Chief02:30
nixonix"We estimate that 11.3%... of patients with COVID-19 in 314 UK hospitals became infected after hospital admission; and ... 6.8% ...of all patients with COVID-19 had nosocomial infections"02:33
nixonixtheres a new word to forget02:33
himesamahospital-acquired02:34
nixonixyeah i looked it up. i guess i remember it when i see it again in a context02:34
nixonix.title https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00357-X/fulltext02:36
Brainstormnixonix: From www.thelancet.com: Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study - The Lancet Respiratory Medicine02:36
LjLquick and dirty just because i'm starting to get lost02:36
LjL%variant indian02:36
BrainstormLjL, That variant may also be called: Delta, B.1.617.2, 21A(Delta); or Kappa, B.1.617.1, 21B(Kappa)02:36
LjL%variant alpha02:36
BrainstormLjL, That variant may also be called: B.1.1.7, 20I(Alpha, V1), UK, Kent02:36
nixonixhere most schools reopened couple days ago. vaccinating of 12-15 yo started day or two earlier, most having it in schools, but it will at least couple of weeks, and immune response to develop, and only the first dose anyway02:39
LjLWin7ine, at this point variant-specific vaccines are being trialed (by BioNTech/Pfizer for Delta and by Moderna for Beta are the ones i know), but they are not in actual production yet. sure the mRNA can be tweaked quickly, but it's not like you can turn millions of existing doses into a different version... plus, streamlining of approval processes for variant-specific vaccines is certainly under discussion but it wouldn't be trivial to just go "yeah let's use02:39
LjLthese without testing them at all"02:39
LjL(although i suspect we will end up there eventually)02:39
nixonixand now im reading its 1.6-4.7 times more severe for kids. our hc officials claiming theres no evidence, while its growing body of evidence from several studies02:40
LjLnixonix, looks like we've already vaccinated a fair amount of 12-18 https://lab24.ilsole24ore.com/numeri-vaccini-italia-mondo/#vaccinati-per-fasce-di-eta02:41
nixonix...times more often severe, that is02:41
nixonixmistakes after mistakes they are doing02:41
LjLit looks actually a bit ridiculous how vaccinated younger people are when 60-69 and 50-59 still have so little coverage02:42
LjL(relatively)02:42
nixonixyou have 3-4 weeks interval?02:42
LjLdepends on the vaccine02:42
LjL3-4 for mRNA, 12 weeks for AZ02:42
LjLbut so yeah i guess 3-4 now mostly02:42
nixonixwe had that only during the first couple of weeks, then it was 11-12 weeks until a few weeks ago they allowed ppl to get it in 8 weeks if they wanted02:43
Win7ineLjL, that is my point while the Pandemic is shifting and is based on Delta Governments are pushing old COVID19 vaccine that is now proven to be unefficient to a high degree in that even double jabbed infected individulas are spreading Delta.02:43
LjLWin7ine, okay, so what would you do?02:43
nixonixwhile i just read somebody was allowed to reduce the interval just 2 or 3 days, the nurse in phone saying the shorter would be bad for ab titers02:44
LjL("unefficient" isn't a word by the way, but the current vaccines are *not* ineffective)02:44
nixonixalso i read several ppl claiming they were refused aspiration, when they asked...02:44
nixonixinefficient is a word i think02:45
Win7ineShift attention to adjusted mRNA vaccine and its availability for a booster sessionn in September02:45
LjLuhm, annoying, i'm pretty sure that vaccine page for Italy used to have a graph indicating *which of each vaccine type* was being used, but it doesn't anymore unless i'm blind :\02:45
LjLWin7ine, they won't be available in September02:45
LjLthere's no way the trials are completed and production is already up by September02:45
Win7ineThe hope was in mRNA being able to adapt quickly once it has a working formula. This was the sales point.02:46
LjLokay i *am* blind. i wasn't seeing that graph because i was zoomed in into it, and so it looked different from what i expected ;(02:46
LjLWin7ine, what about the "sales point" of it having 95% or so efficacy vs 60-70% or so from adenoviral (also a pretty new type), and less than that for inactivated?02:47
nixonixupdted version was supposed to need only a trial of a few hundred, in usa. sure it still takes time. but i wonder what are their real reasons02:47
LjLanyway as i said, yes, you can adapt the mRNA sequence quickly02:47
LjLbut that doesn't mean the *other parts* of vaccine testing and production magically become quicker02:47
Win7ineAs long as there are infections and spreads there will be new variants02:48
LjLthey *can* adapt the mRNA formulation quickly, and they have *already* done so. that doesn't mean you get the booster in the blink of an eye02:48
LjLgee, if they take too long to test, they aren't being quick enough02:48
LjLif they take too short to test, they aren't testing enough, and people won't get the vaccine02:49
LjLi think people are the problem at least as much as the vaccine issues02:49
nixonixthere would be a problem that they had two different vaccines to deliver for quite a while, from different factories02:49
Win7ineIf it took 12 months form 0 to availability then I would expect less time for a new modified version02:49
nixonixit isnt necessarily just quick swap the plasmid template and it starts putting out the new version02:49
LjLit didn't take 12 months from "zero"02:50
nixonixso those getting the old stuff would complain02:50
LjLluckily for us, mRNA technology was being worked on for 20 years, and just happened to be mostly ready02:50
nixonixeven if there would be problems like with OAS (i dont think there would, but i may well be wrong)02:50
Win7inegive that delta has been around since March, correct me if I am wrong, September would be manageable if not all sitting on old stock and the Economy would be paramount as usual over people02:50
LjLnixonix, i don't know what real reasons you're after. the trials are ongoing. i don't think they're past their original due date.02:50
LjLthey might be trials of a few hundreds, i honestly haven't looked at the amount of people involved02:51
nixonixthey did some plain mrna testing before 1990 i think, nanocapsules came a few years later02:51
LjLbut that doesn't mean they last two weeks or something02:51
LjLthe github page does, i think, have a timeline of their announcement including on variant-specific vaccines, at least for Pfizer and Moderna02:51
LjL%variants beta02:52
BrainstormLjL, That variant may also be called: B.1.351, 20H(Beta, V2), South African02:52
LjL%trials moderna B.1.35102:52
BrainstormLjL, 10 results out of 2152: Immunogenicity and Safety of SARS-CoV-2 Recombinant Protein Vaccines With AS03 Adjuvant in Adults 18 Years of Age and Older as a Primary Series and Immunogenicity and Safety of a Booster Dose of SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (Two Monovalent and One Bivalent), dated 2021-02-18 (not completed) → https://clinicaltrials.gov/ct2/show/NCT0476268002:52
nixonixthey saw it taking over in may, in uk and starting to take over in some other countries too. so a few hours to get the updated s-protein. arrange trials, a few weeks. they have trials running for the updated version? started when?02:53
LjLThe duration of each participant's participation in the study will be approximately:02:53
LjLOriginal Phase 2 part: 365 days postinjection 2 (ie, 386 days total). Supplemental Cohorts 1 and 2: 365 days post-booster injection (ie, 366 days total).02:53
LjLSupplemental Cohort 3 and all Supplemental comparator groups: 365 days post-injection 2 (ie, 386 days total).02:53
Win7inemRNA tech was worked on for 20 years but mostly for cancer treatment02:54
LjLnixonix, trial for Beta with Moderna (which they say is effective for Delta too) started in February02:54
LjL%trials biontech B.1.61702:54
BrainstormLjL, 10 results out of 2117: Booster Effects With Autoimmune Treatments in Patients With Poor Response to Initial COVID-19 Vaccine (ACV01), dated 2021-08-06 (not completed) → https://clinicaltrials.gov/ct2/show/NCT05000216 [... want %more?]02:54
LjL%more02:54
BrainstormLjL, [...] COVID-19: Safety and Immunogenicity of a Reduced Dose of the BioNTech/Pfizer BNT162b2 Vaccine in a Healthy Population, dated 2021-04-14 (not completed) → https://clinicaltrials.gov/ct2/show/NCT04852861 [...] → https://paste.ee/p/rGPK702:54
LjL%more02:55
LjLPfizer/BNT are dancing around it for sure02:55
LjLi think AZ are also working on an update, i just kind of ignore them because i doubt Europe will care this time02:55
nixonixthey can possibly fix the clotting problem. and its possible the protection for infection wanes slower02:56
nixonixbut they would use another vector for another dose02:56
nixonixand what about the 3rd then...02:56
LjLthis is fresh https://clinicaltrials.gov/ct2/show/NCT05004181 and combines a B.1.1.7 vaccine with a B.1.351 one apparently02:56
LjLsorry i mean and a B.1.617.2 one, Indian, Delta02:57
LjLanyway i think BNT/Pfizer started trials on variant vaccines much later than Moderna because they were hoping to "hike the prices" for boosters, presumably of the cheaper thing, i.e. the one they already have, as they promised to investors02:58
LjLwhich must have something to do with the FDA and CDC saying "no!" quickly and in stereo when Pfizer said they wanted EUA for a 3rd booster with the same stuff in it02:59
nixonixII.Variant-specific booster candidates: mRNA-1273.351 & mRNA-1273.617 (new)  III. Multi-valent platform: mRNA-1273.211 & mRNA-1273.213 (new)02:59
LjLbut i think Pfizer will win anyway, and we'll get a third dose with the original vaccine, because we can see now that immunity does wane02:59
nixonixyou saw those moderna links another day, with info on update?02:59
LjLnixonix, not sure really, i remember something about injecting the first participant, but that might have been pfizer03:00
LjLwhich sort of update03:00
nixonixim not sure, but i think the pdf was from this link https://investors.modernatx.com/news-releases/news-release-details/moderna-reports-second-quarter-fiscal-year-2021-financial/03:00
LjLah yeah, a lot of stuff in that one03:01
nixonixif you check it from logs, i had couple other links too, and/or quotes03:01
LjLlast i saw it, it was a presentation, though...03:01
nixonixusa approved 3rd shots03:02
LjLthis was the presentation https://investors.modernatx.com/static-files/c43de312-8273-4394-9a58-a7fc7d5ed09803:02
LjLnixonix, USA only approved 3rd shots for immunocompromised03:02
nixonixfull approval supposed to come in couple of weeks. and prob also 5-11 yo vax03:02
nixonixnot all old or something yet?03:03
LjLLibera/##covid-19/2021-07-09.log:[19:53:22] <Brainstorm> New from WebMD: CDC and Pfizer at Odds Over Need for COVID-19 Booster Shots: Pfizer and its partner, BioNTech, say research is showing the need for a booster shot of its COVID-19 vaccine, but the CDC, FDA and National Institutes of Health disagree -- for now. → https://is.gd/jkKZQU03:04
LjLLibera/##covid-19/2021-07-09.log:[21:38:13] <Brainstorm> New from FDA Press Releases: FDA: Joint CDC and FDA Statement on Vaccine Boosters → https://is.gd/NLMl7c03:04
LjLLibera/##covid-19/2021-07-09.log:[23:02:25] <Brainstorm> New from CIDRAP: CDC, FDA contradict Pfizer on COVID-19 vaccine booster: Stephanie Soucheray | News Reporter | CIDRAP News Jul 09, 2021 "Americans who have been fully vaccinated do not need a booster shot at this time," the agencies say. → https://is.gd/QU8C3M03:04
LjLfull approval was explicitly denied03:04
LjLsure they may change their mind now that waning was demonstrated03:05
LjLand i'm sure Pfizer are rubbing their hands about it03:05
LjLand i've always said this is a potential conflict-of-interest issue: the vaccine makers are going to be most interested in vaccines that countries 1) will want to buy, but 2) that won't provide full, long-lasting immunity, so that they can sell more later03:06
nixonixmaybe they diluted their shit...03:06
Win7ineLjL I agree03:06
nixonixanyways, i read somewhere that moderna's codone optimizations are worse than pfizers. how were the ab titers compared?03:07
LjLthe vaccines don't make you magnetic, they don't change 5G reception, they don't restore, or further destroy, the lost moon landing footage; but once we've taken away all this anti-vax nonsense, the fact remains that there is a market that demands profit.03:07
LjLnixonix, so far it seems that Moderna is faring better than Pfizer, from some latest studies (Qatar, Mayo Clinic), although it was countered there may be an artificial effect of antibody waning, where Pfizer seems to work less well simply because it was, on average, given longer ago than Moderna03:08
LjLi dunno if you can compare the AB titers directly since Moderna has a lot more mRNA in one shot than Pfizer03:09
nixonixthey vaccinated people earlier with pfizer in quatar, and according to some source, that would be the case in that mayo study too03:09
nixonixand large confidence intervals03:09
Win7ineLjL an there we are: All Health related cannot be treated as a business, it is pervers doing so.03:10
LjLalthough i'd be surprised if Mayo hadn't adjusted the cohorts to take that into account...03:10
nixonixthey didnt have the vaccination dates03:10
LjLWin7ine, well, we should have waken up about that years ago. probably can't do it now in the middle of a pandemic. and we tried anyway - there were some strong players demanding patents be dropped, but it didn't happen03:11
LjLnixonix, they did have the vaccination dates i think, i remember it being mentioned in the abstract...03:11
nixonixwas it. i try to find the stuff i had on all that mess tomorrow03:12
LjLnixonix, "We defined cohorts of vaccinated and unvaccinated individuals from Minnesota (n = 25,589 each) matched on age, sex, race, history of prior SARS-CoV-2 PCR testing, *and date of full vaccination.*"03:12
LjLhttps://www.medrxiv.org/content/10.1101/2021.08.06.21261707v203:12
himesamawhen were the qatar subjects likely vaccinated03:13
nixonixhmm, maybe it was something else .. ah i think i remember the claim, those people that were selected for early vaccinations were different. something03:13
nixonixbut i dont know if it was true or not03:14
himesamaearlier than may?03:14
LjLdunno03:15
nixonixdamn im too tired, and ive been off rom l-theanine for 2 days to test if i notice the difference03:16
nixonixbut i found the source, rereading03:16
nixonixSoundarajan also noted that the nanoparticulation and nucleotide sequences used in the vaccines are different,  but the prevailing hypothesis is that Moderna is more effective against the variant due to the greater amount of mRNA in the vaccine. The Moderna vaccine, especially the second shot, is associated with a greater increase in mild side03:17
nixonixeffects compared to Pfizer, Soundarajan added.03:17
nixonix"Thinking back, we think that might be because of the dose," he said. "There is more mRNA, which means it boosts a stronger immune response."03:17
nixonixThere are some "caveats" to the study, Soundarajan said. For one, genome sequencing is limited, so the study authors estimated the number of suspected delta variant cases using inferred data. In other words, those studied were not necessarily infected with the delta variant, but were suspected as being so as it is the prevailing variant in the U.S.03:18
nixonixright now.03:18
nixonixThe study authors are also unsure whether the lower effectiveness of the Pfizer vaccine is due to its status as the first vaccine to receive FDA emergency-use authorization. Because Pfizer's vaccine was the first approved, it was rolled out to communities with higher risks of contracting serious side effects from the coronavirus, Soundarajan said.03:18
nixonixHealth care workers and elderly people living in care facilities received the vaccine first, for example, and the data may be inflected by this fact03:18
nixonix.title https://www.sfgate.com/coronavirus/article/Pfizer-moderna-vaccine-effective-delta-variant-16380022.php03:18
Brainstormnixonix: From www.sfgate.com: Pfizer vaccine less effective against delta variant transmission compared to Moderna, says study03:18
LjLnixonix, but still the main claim is it's probably because of the dosage (which is actually going to be a bummer for Moderna as they were just trialing a half-dose regimen)03:21
nixonixtech from nanoparticle comes from the same company, but maybe its still different with them03:21
nixonixthe mrna induced immune reactions may be different, prob mostly or only due to difference in amount. but pfizer is more effective in production supposedly, with less.03:22
nixonixhow is it with viable-damaged ration then - i remember pfizer had problems during the late 2020 if those leaked documents were real, or unaltered from those parts03:23
fooI don't think there's any certainty yet on natural immunity from getting the virus versus getting a vaccine, is there?03:23
nixonixso id like to compare the ab titers. the problem is, the measurement isnt standardized, and varies even within the lab, who does the analysis03:23
LjLfoo, certainty would be a tall call, but some other recent study found, i think, longer-lasting antibody titers from people who had had an infection and *then* mRNA, compared to those who had just two doses of mRNA03:24
nixonixand also depends on selection of the neuts used, and individual differencies of the donators03:24
fooLjL: thank you03:24
LjLi think i remember from older studies that *just* an infection, without also a vaccine, was lower03:24
nixonixare they called donators, idk...03:24
LjLbut an infection plus a vaccine might well be the "best" combination (presuming you survive the infection unscathed...)03:25
himesamaproduction of what --- 18:22 <nixonix> the mrna induced immune reactions may be different, prob mostly or only due to difference in amount. but pfizer is more effective in production supposedly, with less.03:25
nixonixprotein03:25
Win7ineBionTech and Moderna only have supple differences and hiw about people who had 2 x mRNA and Delta infection on top ? Some ended up in ICU.03:25
nixonixdue to better codone optimization, is the claim anyway03:25
nixonixsynthesis of s-protein in cells03:26
fooIs there anyone in here who believes that side effects of the vaccine aren't fully understood? Not looking to start any "funny business" here, simply curious. eg. I recently saw the vaccine altered the menstrual cycle in women03:26
himesamaare there proportionately more excipients in moderna than pfizer?03:27
himesamanixonix: so you are saying pfizer does more with less of the mrna?03:28
nixonixid like to see some study on that, but sure the innate immune reaction in the first couple of days could do lots of things, just usually quite mild effects. then later antibodies, who knows what receptors they bind03:28
nixonixbut if they bind to something that causes shit, the infection would be worse03:28
LjLfoo, only thing i heard about menstrual cycle is that some anti-vaxxers claim it alters the menstrual cycle of women who have NOT received the vaccine to be near women who have. so there's starting to be a movement to be vaccinated against the vaccinated (or simply to avoid them), which i find beyond ridiculous. so while it's entirely possible there have been such effects, i'd urge to double-check your sources03:29
LjL%papers menstrual cycle vaccine03:29
BrainstormLjL, 10 results out of 13115: Changes in RT-PCR test results and symptoms during the menstrual cycle of female individuals infected with SARS-CoV-2: Report of two cases by Hua Zheng et al, dated 2020-07-09 → https://www.doi.org/10.1002/jmv.26275 [... want %more?]03:29
fooLjL: lol, that's hilarious.03:30
himesamanixonix: which would you choose pfizer or moderna03:30
LjLfoo, but to answer your direct question, yes, i do believe side effects of the vaccines are not fully understood. after all, we weren't quite expecting that rather strange type of blood clots from AZ, nor the myocarditis from mRNA03:30
nixonixits more efficient, dose by dose. pfizer. but idk if moderna produces more s-protein because theres 3x as much mrna. they need more mrna with moderna. maybe not that much more but who knows (they are testing with 50 mcg, supposedly with good results)03:30
LjLfoo, in my view though, what's even less understood is the "side" effects of COVID itself, which are very wide-ranging and much more frequent than those of the vaccines...03:31
nixonixid like moderna as a 3rd with the current knowledge they have. but its uncertain information, if it really lasts longer03:31
nixonixthere is a eco hair dresser or what are they called, in finland that had on their web page, that they dont want customers having a vaccine dose within month before coming as a client03:33
fooLjL: understood. In the interest of transparency, I'm somewhat vaccine hesitant - I realize, logically, the vaccine makes sense. But that "sense" makes "sense" (haha) when the data is trusted. And I have trust issues (partly joking here, but I do have some family trauma from the medical system...) - to be fair, I also rarely see anyone, ever, and control my environment rather well.03:33
nixonixthat spike protein shedding shit of antivaxers03:33
Win7inefoo, take "LONG Covid" for instance, highly individual, dpending on age group, inflammatory mostly in nerves, brain and evidently in blood vessels03:34
LjLfoo, also you know, there's a lot of side effects of common drugs that we don't "fully understand" (often we don't even understand how those drugs work in the first place, only that they do, from statistical results from trials...) - for example i see this article about the phenomenon you mention https://www.npr.org/sections/health-shots/2021/08/09/1024190379/covid-vaccine-period-menstrual-cycle-research and it points out that the birth control pill can also cause03:34
LjLshort-lived changes in the menstrual cycle (and that the ones potentially caused by the vaccine seem to be short-lived, too). and yet a lot of women take the pill without worrying too much about all that.03:34
nixonixbtw there are suspected skin things and kidney things from mrna vaccines, maybe mentioned here already. not confirmed, google im too tired to find03:35
LjLfoo, in the interest of transparency, i'm scared as hell of COVID, so i was kinda begging to be jabbed, but only because i trust the vaccine more than i trust COVID - which is a pretty damned low bar :P03:36
fooLjL / Win7ine - thanks, again - not trying to "start anything" here - just a dude genuinely trying to think through this. I'm also open to deciding "no" for right now and waiting a bit until there's more data.03:36
himesamafoo: i don't call that antivax.  i cal it sensible.  but that doesn't mean you sholdnot do the vaccine.03:36
fooLjL: haha.03:36
fooI've also spent like $5k+ on my health in 2019 doing extensive blood work, neuro work, gut health etc03:36
LjLi don't call that anti-vax either, per se03:36
fooI would love to see more data... it seems like a lot of things are "general"03:37
himesamado you have diagnoses03:37
himesamaor are you trying to get diagnosed03:37
fooeg. all things considered, if we taken the "general health of the world" (which, given fast food joints / etc).... then sure, if we're solving for lowest common denominator, let's take a jab to make this as easy as possible.03:37
fooNot blaming or even saying that's the case, I'd just love some more data here03:37
fooeg. people who get long covid likely have X, Y ... I can't imagine long covid is random03:38
himesamai thin there shoudl be significantlyu more data03:38
foohimesama: me? I don't have covid-19, my parents do right now.03:38
LjLit isn't random, but it isn't true that people who get long COVID necessarily "have" things, either03:38
LjLit may be more common when they do have things03:38
fooLjL: "have" might not be the best phrase, even if someone has certain health dynamics03:38
himesama18:36 <foo> I've also spent like $5k+ on my health in 2019 doing extensive blood work, neuro work, gut health etc03:38
LjLwe also don't really have a clue what exactly "long COVID" is... whether it is a thing, multiple things, whether it's similar or different to other post-viral syndromes...03:38
foohimesama: oh, I was curious and did a ton of tests in 201903:39
fooLjL: I see, thanks.03:39
Win7inefoo, all data is collected by the bodies governing studies hence what yuo will ever obtain is what they will give you03:39
himesamayou don't hae to tell us but if you have something possibly lc related then you might be at genetic risk of lc03:39
LjLfoo, we know for example that persistent symptoms have even been reported in a large percentage of *children* who got COVID, which i find not at all comforting03:39
nixonixdid my tinnitus almost disappeared when im off l-thenine? or is it just abs waning, if they caused it03:40
nixonixprob abs, im not leaving theanine or coffee, no matter what03:41
LjLnixonix, now if you make me think that l-theanine may cause tinnitus, i'll never try it ;(03:41
LjL(cause/exacerbate)03:41
nixonixhaha, then you can stop if it does03:41
fooLjL: not comforting at all03:41
LjLnixonix, well, i don't know, i have suspicions that my tinnitus was caused by medications to begin with, and it certainly didn't go away03:41
foohimesama: thank you for asking :) From my assessments, I had low seratonin and gaba, overgrowth of a certain gut bacteria which affected my body's ability to absorb zinc which affected allergies, and my cortisol levels throughout the day were jacked (it was highest at night and lowest in the morning... which is the opposite of what it should be)03:42
fooLjL: I have a friend who has that, it sounds annoying. Someone else I know said it's from loud stuff... but another friend who has had it most of his life.03:42
nixonixits just amino acid you get from whey and what not. sold in big cans, cant harm a small spoonful03:43
LjLfoo, this channel has a few resources i gathered together at https://github.com/ljl-covid/links and in particular https://github.com/ljl-covid/links#follow-up is mostly about long COVID. also since it was becoming a burden to update it, i started a Zotero library, which is easier to maintain, and this is what you get if you search for the tags "Long COVID" and "Children": https://www.zotero.org/groups/4391070/covid_links/tags/Children,Long%20COVID/library03:43
fooLjL: thank you.03:43
himesamawhich type of bacterium?  the reversed phase of cortisol is common in m.e. which is possibly related to lc and is possibly genetically influenced.03:44
LjLfoo, in my case i haven't had it for most of my life (started in 2017), and it's also most likely *not* from loud sounds, so it's either a bit of an unlucky random thing (after all, about 15% of the population have tinnitus), or related to some medication i took, or the reasons i took them for03:44
fooI had to stop watching the news, I found myself obsessing. I have also been heavily shamed by certain family members for not being vax'd which caused me to do some more research. heh03:44
foohimesama: thanks for digging, what's "lc" ? The specific gut bacteria was... hmm...03:44
LjLlong covid03:44
himesamabutyrate-producing or not03:45
himesamanever mind that part03:46
fooI also did a lot of stool testing03:46
fooahh03:46
fooProteus mirabilis is what I had an overgrowth of03:46
LjLnixonix, do you hear your tinnitus stronger just after waking up by any chance?03:46
himesamahave not hear dof that one03:46
fooAlso, for the record - I haven't had covid - at least to my knowledge.03:46
LjLfoo, you said your parents have COVID at the moment?03:47
nixonixyeah its ear thing after some cold, it went away, but then lately came back milder. then somehow a bit later than 2nd dose increased, and now it seems to be better03:47
nixonixno i didnt have rona! some cold03:48
fooLjL: yes03:48
fooLjL: they're like day 10 I think03:48
LjLfoo, are they vaccinated?03:48
LjLand how are they?03:48
fooLjL: no, also just hesitant and "waiting and seeing" -> father got it from someone at work. I've basically worn masks around them whenever I visit (unless I haven't seen anyone 2 weeks prior, which has happened often with my off-the-grid camping/working lifestyle, ha)03:49
fooLjL: thanks for asking, they're doing ok. It seems to linger, cough03:49
fooBad headache03:49
LjLfoo, cough often does seem to linger, yeah headache too, fatigue most commonly03:49
fooYup, that's mostly what I've been hearing from them03:50
LjLfoo, please don't think that masks are a 100% protection. they are not by any means03:50
fooI'll see them in 1 week, which is like 20 days from when they tested positive03:50
LjLthey are probably useful, for sure, but they are not an invisible shield03:50
fooLjL: nah, I understand. I'm usually masked and as far on the side of the room as I can, especially if we're eating, haha.03:50
LjL(especially surgical or cotton masks, but respirators too)03:50
fooI have KN94 masks03:50
LjLthat's either KN95 or KF94 :P03:50
LjL... or a scam :D03:51
LjLanyway, the certification doesn't really matter... N95, KN95, KF94, FFP2 are all roughly-equivalent certifications. what matters is the actual mask quality, which is often abysmal at least with KN9503:52
fooLjL: or a foo-ism? :P My mistake, I have this: https://behealthyusa.net/products/botn-kf94-mask-black-large-100pcs03:52
LjLgood masks have a tight fit - which means nowhere for air to get into your nose without having gone through the mask first03:52
fooLjL: my ear-deformation, sometimes, when wearing a mask tells that story. haha.03:53
LjLfoo, KF94 is the Korean certification, and i kind of like that Korean type (which again, is not to do with the certification, it's just that it's common in Korea and that's their certification!)03:54
LjLbut the 3M Aura is a mask in a similar style that's better-built than most and has straps that go around your head instead of around your ears03:54
fooLjL: I see :) A doctor friend recommended this at the start of the pandemic. I'm still going through my box since I don't wear them that often03:54
fooOhh03:55
LjLthat's kind of important because the ones that go around your ears generally just aren't enough for a tight fit (unless they saw off your ears in the process)03:55
LjL3M Auras however are pretty expensive03:55
LjL(at least here and compared to random KN95 or KF94 masks)03:55
LjLi see the ones you got have adjustable earloops though, which isn't very common, they might well be pretty good masks03:56
LjLbut ultimately you're the one who needs to tell... breathe in, breathe out, somewhat strongly, and try to notice if any air escapes03:57
fooLjL: I believe you're talking about these: https://www.homedepot.com/p/3M-Aura-Particulate-Respirator-N95-Foldable-10-Pack-9205P-10-DC/31690932203:57
fooLjL: I usually am mask-confident... until I happen to be somewhere and smell someone's perfume strongly, then facepalm.03:57
LjLfoo, i think the model number is different but that may just be because mine are FFP2 certified while those are N95 (which makes no difference)03:58
fooLjL: I see, thanks for sharing here. :)03:58
LjLjust be careful with those headstraps with the Auras, they're more flimsy than they should be for the price (but they will likely go around your head without breaking... when you try at first, it will seem like they won't :P)03:59
LjLimportantly imo, they have a foam pad where your nose goes (not just the metal bar), which helps a lot in making the fit tight around your nose03:59
himesamathe half faceplate masks have enormous good thing and a couple of bad. first you can test whether they have a seal or not. i don't think you can with n95 type masks without special equipment like smoke and a nose that works.  this is enormous.  they do have flimsy valves which means ocacsionally a little of your breath will go backward through the canisters.  they also have an exhale valve that can stick and require04:05
himesama force to breathe out.  and finally valves mean you are not protecting others.  i wonder if there are any attachments that will put a filter over the exhale valves of half faceplate masks.04:05
himesamathe ability to fit with triple flange is enormous.  even if you have not shaved recently opr annot shae3 recently it can still form a seal unlike the good n95 dispoables.04:05
himesama(also, i am guessing you can't  test exhalation leaks on disposable n95 at all)04:06
fooI wonder how soon we'll have test-at-home kits for like $20 or something04:11
de-factohere they sell them for 80 cent04:14
de-factoin all supermarkets in germany04:14
foode-facto: uh, what?! a test you can self-administer at home?04:16
de-factoyes those rapid antigen tests04:16
Win7ineIN UK you get the Lateral low Tests for free delivered to your address04:17
JbwncsterI wish having a mask mandate would allow the police to fine people04:18
JbwncsterThey’re afraid to fine people here04:18
JbwncsterThe new mandate would be enforced heavily through education and not law enforcement, according to Raleigh Mayor Mary-Ann Baldwin.04:18
JbwncsterSo why the fuck are you making a mandate if the police can’t do anything04:19
himesamaperhaps there are still those who will do it een if it is not enforced.  for example a company could say this is the alw we will fire yoyu.04:21
JbwncsterYeah04:21
JbwncsterMy old job wouldn’t even stop customers from coming in without a mask04:22
JbwncsterAnd it was a pizza shop04:22
JbwncsterSo I quit04:22
JbwncsterAnd they defied curfews04:23
himesamamaybe there are things you can do at nc state or duke or uncch or something04:24
JbwncsterState isn’t requiring students to be vaccinated04:25
himesamais this the govcernor going against what they want or what04:26
JbwncsterIdk04:27
JbwncsterAlso apex, fuckway vagina and holly springs won’t have a mask mandate04:27
himesamait does not seem possible to be safe at a university or a restaurant04:28
himesamabut sturgis is going to be something to keep track of :(04:28
JbwncsterI wish tillis would go away04:29
JbwncsterAnd whomever replaces burr better be a democrat04:29
himesamais helms gone04:32
JbwncsterLong gone04:33
LjL%title https://www.youtube.com/watch?v=z38NWVXky2Q04:46
BrainstormLjL: From www.youtube.com: Israeli health chief explains decision to begin COVID-19 booster shots - YouTube04:46
twomoonwhere u at Jbwncster04:48
JbwncsterNorth Carolina04:49
twomoonit seems states are becoming more extreme04:49
LjLsome interesting information towards the end of that04:51
lastshellkind of late but you can validate your kn95 if you fill with water and wait how long takes to leak05:42
lastshellthere are other steps to validate at home, but I forgot the other steps05:43
twomoondoes yours stop cig smoke?05:45
twomoonljl 80% of vaccinated folks in israel who have become confirmed positive cases don't have any contacts that have been confirmed positive cases06:37
twomooni don't know what to make of that06:37
himesamais that partiularly uncommon?06:52
himesamai was refering to testing the seal, not the filter.  but indeed it is good to test filters too if you don't ruin them by testing.  --- 20:42 <lastshell> kind of late but you can validate your kn95 if you fill with water and wait how long takes to leak06:54
himesamai do wonder if, say, touching the pleats on the inside of a canister is ok.06:54
himesamaseal against you, as in the fit06:55
Juerdlastshell: If your kn95 doesn't leak water, that proves it's water tight. Nothing more or less, sorry.07:00
Juerdlastshell: There are masks that actually do filter particulates but let water through (even if they are uncommon), so it doesn't mean anything either way.07:01
Juerdlastshell: The outside should be hydrophobic though. Drops of water should run of in beads, leaving little if anything behind.  And you can test whether the inner layer is meltblown as it should be by cutting the mask open and separating the layers, and then using the inner layer to try to lift up some tiny pieces of paper (just regular printer paper that you tore to ~ 7x7 mm bits). The static07:04
Juerdcharge should be able to lift pieces of paper. The inner layer should also statically stick to most tft screens.07:04
JuerdIf it does that still doesn't validate the mask's filtration, but it does make it more likely to have at least some filtration.07:04
JuerdThere is no way without proper measuring equipment, to verify that a filter medium actually does what it should.07:05
himesamait would seem a huge market to create a filter for the exhaust for half faceplates, and for upgrading the valves in them07:16
himesamai wonder how good the full faceplates are wrt fogging glasses etc.07:16
himesamai also wonder whether any filter material withstands sustained high heat like 115f temperatures (espeially n95 masks and p100 cartridges for half-faceplate)07:26
-Bridgestorm- 🌒 Earthquake! 5.9 Mb tremor, registered by alomax,scevent, occurred 12 minutes ago (09:50:13 UTC), with a crescent moon, Tonga Islands Region (-22.43, -174.09) likely felt 260 km away (in Nukuʻalofa…) by 36000 people (quakesearch.geonet.org.nz)12:02
purplesail[m]%cases world12:35
Brainstormpurplesail[m]: Sorry, world not found. Either there aren't cases, or it's under a different name.12:35
purplesail[m] * %cases Dortmund12:36
purplesail[m]%cases Dortmund12:36
Brainstormpurplesail[m]: Sorry, Dortmund not found. Either there aren't cases, or it's under a different name.12:36
purplesail[m]%cases Berlin12:36
Brainstormpurplesail[m]: Berlin, Germany has had 186394 confirmed cases (5.4% of all people) and 3588 deaths (1.9% of cases) as of 4 hours ago. +614 cases since 7 hours ago. See https://offloop.net/covid19/?default=Berlin12:36
Brainstormpurplesail[m]: If you know of an official or otherwise good site for data about Berlin, with a reasonably short URL, please %tell LjL about it.12:37
purplesail[m]!London12:40
purplesail[m]!cases London12:40
purplesail[m]%cases London12:40
Brainstormpurplesail[m]: Sorry, London not found. Either there aren't cases, or it's under a different name.12:40
de-facto%cases UK12:41
Brainstormde-facto: United Kingdom has had 6.2 million confirmed cases (9.4% of all people) and 130959 deaths (2.1% of cases) as of 4 hours ago. 255.4 million tests were done (2.4% positive). 47.2 million were vaccinated (71.1%). +14752 cases, +124 deaths since 7 hours ago. See https://coronavirus.data.gov.uk/12:41
Jbwncster%cases USA12:43
BrainstormJbwncster: United States has had 37.0 million confirmed cases (11.2% of all people) and 629684 deaths (1.7% of cases) as of 4 hours ago. 553.9 million tests were done (6.7% positive). 197.1 million were vaccinated (59.8%). See https://offloop.net/covid19/?default=United%20States12:43
BrainstormJbwncster: If you know of an official or otherwise good site for data about United States, with a reasonably short URL, please %tell LjL about it.12:43
IndoAnon%cases jakarta12:45
BrainstormIndoAnon: Jakarta, Indonesia has had 25297 confirmed cases (0.2% of all people) and 924 deaths (3.7% of cases) as of 12 hours ago. See https://offloop.net/covid19/?default=Jakarta12:45
BrainstormIndoAnon: If you know of an official or otherwise good site for data about Jakarta, with a reasonably short URL, please %tell LjL about it.12:45
Jbwncster%cases Kiribati12:46
BrainstormJbwncster: Kiribati has had 2 confirmed cases (0.0% of all people) and 0 deaths (0.0% of cases) as of 12 hours ago. 13970 were vaccinated (11.6%). See https://offloop.net/covid19/?default=Kiribati12:46
BrainstormJbwncster: If you know of an official or otherwise good site for data about Kiribati, with a reasonably short URL, please %tell LjL about it.12:46
Jbwncster%cases Mongolia12:46
BrainstormJbwncster: Mongolia has had 181291 confirmed cases (5.5% of all people) and 872 deaths (0.5% of cases) as of 4 hours ago. 3.4 million tests were done (5.3% positive). 2.2 million were vaccinated (67.0%). +467 cases since 7 hours ago. See https://offloop.net/covid19/?default=Mongolia12:46
BrainstormJbwncster: If you know of an official or otherwise good site for data about Mongolia, with a reasonably short URL, please %tell LjL about it.12:46
IndoAnon%tell LjL  https://corona.jakarta.go.id/en/data-pemantauan12:48
BrainstormIndoAnon, I'll pass LjL your message when they are around.12:48
-Bridgestorm- ⭕ Temblor! Tranbleman tè! Séisme! Earthquake! 6.6 Mi tremor, registered by PT,alomax, with 2 reports, 2 early, occurred 13 minutes ago (12:29:08 UTC), during daytime, Petit Trou de Nippes, Haiti (18.52, -73.52) ± 6 km, ↓9 km likely felt 440 km away (in Aquin, L'Anse-à-Veau, Les Cayes, Miragoâne, Jérémie…) by 522000 people (earthquake.usgs.gov)14:42
-Bridgestorm- ⭕ Tranbleman tè? Séisme? Earthquake? M7- estimated tremor, registered by GEOFON, possibly occurred 19 minutes ago (12:49:00 UTC), during daytime, Haiti Region (18.69, -73.54), ↓10 km likely felt 400 km away (in L'Anse-à-Veau, Aquin, Jérémie, Miragoâne, Les Cayes…) by 600100 people (Twitter)15:08
-Bridgestorm- 🏠 Tranbleman tè! Séisme! Earthquake! 5.7 Mb tremor, registered by GEOFON,US, occurred 23 minutes ago (12:49:34 UTC), during daytime, Haiti Region (18.48, -73.78) ± 20 km, ↓10 km likely felt 240 km away (in Jérémie, Les Cayes, Aquin, L'Anse-à-Veau, Miragoâne…) by 4.1 million people (service.iris.edu)15:12
lastshellhttps://www.reviewjournal.com/local/local-las-vegas/vaccinated-las-vegas-flight-attendant-dies-from-covid-mother-says-2419704/amp/15:53
lastshellnow vaccinated people are dying15:53
purplesail[m]%cases ukraine15:55
Brainstormpurplesail[m]: Ukraine has had 2.3 million confirmed cases (5.5% of all people) and 54651 deaths (2.4% of cases) as of 8 hours ago. 11.7 million tests were done (19.8% positive). 4.6 million were vaccinated (11.1%). +1571 cases, +54 deaths since 7 hours ago. See https://covid19.rnbo.gov.ua/15:55
de-factowell lastshell how many of them though? and how does that compare to non-vaccinated exposed to same thread levels (e.g. similar age group, variant, timeslot, contamination type etc)15:57
de-factoa single anecdotal case does not say much, we would need statistics to derive anything other than "shit happens" from it15:58
de-factoit could be early signs of problem, yeah, but it also could just be that this particular individual was unlucky for some reason15:59
dTalmaybe it was one of those deaths falsely recorded as covid that I've been hearing so much about from the denier camp16:00
lastshellthe person who die was 36, black and in his picture looks healthy16:02
lastshellscary16:02
de-factoits all about probabilities, hence the necessity for more numbers in order to derive a statements that represents circumstances in majorities16:03
lastshellwhere do they track those numbers16:03
de-factoi assume CDC does, wouldnt it be their responsibility?16:03
lastshellI also saw this article but goes above my comprehension https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext16:03
lastshellI'm just scare becasue I eat indoors yesterday16:06
de-factohmmm but for now both breakthrough and hospitalization are lowered in fully vaccinated challenged with delta, arent they?16:09
lastshellI think so, delta is the problem16:10
de-factoand also humoral immune reaction is only one branch, there also is cellular immunity, depending on much smaller fractions of antigen, hence may recognize also cells blooming with mutants16:13
lastshellsorry I'm not well educated in the realm of that science16:13
lastshellso I was not able to understand16:13
lastshellit means some people can get it and others no ?16:14
lastshellor if you have some docs/ links I can start reading (I'm a self learner)16:15
de-facto.title https://www.frontiersin.org/articles/10.3389/fimmu.2020.01949/full <-- maybe that one expains some details16:25
Brainstormde-facto: From www.frontiersin.org: Frontiers | Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past | Immunology16:25
de-factoover a year old though16:26
de-factomany other papers exist about that topic16:26
lastshellthank you16:36
lunatuneshttps://www.youtube.com/watch?v=vv21xbWghvk19:04
lunatunesLive stream of Aaron Collins doing Mask filtration tests19:04
lunatuneshttps://docs.google.com/spreadsheets/d/1M0mdNLpTWEGcluK6hh5LjjcFixwmOG853Ff45d3O-L0/edit#gid=197683976319:04
lunatunesHis google spreadsheet of all his data19:05
lastshelllunatunes thank you very good spreadsheet19:17
lunatuneslastshell: you're welcome. Not saying his tests are on the level of professionals but they do seem pretty good.19:23
lunatuneshttps://docs.google.com/spreadsheets/d/1i06OAItoOwIUaMjElr8mhh0Rw-it6WL-ODIQMZUOQxE/edit#gid=019:32
lunatunesHis spreed sheet of kid masks19:32
lunatunesspread*19:32
Julius__Hi guys20:09
Julius__Do I get banned for thinking that Covid-19 does not exist?20:10
ublxprobably20:11
ublxunless you keep it to yourself, then it might take us a while to notice20:11
Julius__Do people in here even know what Covid-19 is?20:11
lunatunesI find it odd how some search for channels like this just to...argue lol20:13
LjLJulius is an old acquaintance20:15
LjLQED, just banned him elsewhere20:23
lunatunesah I see.20:26
LjLi don't understand a thing this Collins guy says :P20:30
LjLbut the spreadsheet is probably more usable than endless live streams20:30
LjL%links aaron collins20:37
BrainstormLjL, https://drive.google.com/drive/folders/1eE2BERAvRzs28kG87ft3a27FS9-gHvdC (Mask testing data by Aaron Collins), a list of single-use respirators (N95, KF94, KN95, FFP2 masks) for adults and children with measurements of filtration efficacy, pressure drop (measured by an amateur, so not to be taken as professional measurements) and other characteristics like size and strap types20:37
de-factoNetherlands 2021-08-14 https://coronadashboard.government.nl/landelijk/intensive-care-opnames daily 2,349 cases, 63 hospital admissions, ~13 ICU admissions (total 198), 6 deaths, 98,3% Delta20:44
de-factoReproduction ~ 0.8720:45
lunatunesLjL: well the live stream is mainly just him testing the masks right now. He wasn't really answering questions He was just showing how he does the tests.20:45
de-factohttps://coronadashboard.government.nl/landelijk/reproductiegetal20:45
lunatunesBut yeah the spreadsheets give way more information.20:45
LjLlunatunes, but his videos also seem to mostly be saved live streams. it would be interesting if he has *shorter* feature videos about individual good masks, or comparisons, and so20:48
LjLbut i guess the spreadsheet does that, just less multimediatically20:48
lunatunesYeah his videos are really long. But you would have to search a bit to find what you're looking for. He does have the comparison videos though they're just like from 6 to 4 months back.20:49
lunatunesHe will be posting a new comparison video on Monday though about the kid masks20:49
LjLfrom a cursory glance it seems he may sort of like some KF94 masks20:51
LjLwhich matches the impression i was getting20:51
LjLi mean unsurprisingly he recommends 3M Aura as top choice20:52
LjLbut apart from that, which is expensive, some KF94 has the same "bifold" shape and look interesting20:52
Arsanerit3m Aura is good but the straps are por imho21:01
ArsaneritHow did NL get R down to below 1?21:01
LjLi agree, bad straps21:05
twomoonis anyone still watching Doc Campbell's videos?22:48
twomooni think he needs to figure out how to make his videos shorter22:48
twomooni'm falling asleep to his videos22:49
LjLyeah, i'm not22:52
LjLi have a couple of videos queued from a doctor who's less sleep-inducing :P22:52
LjL"Medlife Crisis", although initially he didn't make videos about COVID, he made some eventually22:52
leannotmeansince i started to look for some pediatric sars2 stuff, i thought i might paste some of them here with the same trouble23:50
leannotmean.title https://mobile.twitter.com/GYamey/status/142523326992312320023:50
Brainstormleannotmean: From mobile.twitter.com: error parsing title ('NoneType' object has no attribute 'string')23:50
leannotmean.title https://mobile.twitter.com/DataDrivenMD/status/1425291619683627016  check the whole thread23:51
Brainstormleannotmean: From mobile.twitter.com: error parsing title ('NoneType' object has no attribute 'string')23:51
leannotmeangod damn it!23:51
LjL:(23:51
LjLoh it's because you're linking from mobile.twitter.com23:52
leannotmeanits the curse when i accidentally forgot to use 12+1 first23:52
leannotmean.title https://twitter.com/DataDrivenMD/status/1425291619683627016  check the whole thread23:52
Brainstormleannotmean: From twitter.com: Jorge A. Caballero, MD (@DataDrivenMD): "2/ Since the pandemic began, we’ve never had a greater share of #COVID19 hospitalizations that are children" | nitter23:52
leannotmean.title https://twitter.com/GYamey/status/142523326992312320023:53
Brainstormleannotmean: From twitter.com: Prof. Gavin Yamey MD MPH (@GYamey): "We have a surge in pediatric Covid hospitalizations. My colleagues have never seen anything like it. They’ve never seen this many sick kids with Covid on ICUs. [...]23:53
nixonix.title https://www.theguardian.com/commentisfree/2021/jul/26/covid-young-people-england-virus-spread-uk23:53
Brainstormnixonix: From www.theguardian.com: Will Covid become a disease of the young? The world is watching England to find out | Devi Sridhar | The Guardian23:53
nixonixlung docs instructions for students how to properly put on ffp mask  https://unitube.it.helsinki.fi/unitube/embed.html?id=ecd966ae-4727-438e-bf38-a844d408bb3123:56
LjLi don't know if i should insist on this issue of COVID in children with someone who has children... they're worried but i'm not sure they can decide to pull them out of school without huge repercussions. so if they cannot really do much, then linking these things to them will just make them worry a lot with nothing gained.23:56
nixonixi dont know what to say. here most parents havent taken their kids out of schools when they have been open and not remoting, but the situation now is different, cases are as high as the peak last winter, and its more dangerous variant23:59

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