libera/##covid-19/ Wednesday, 2021-08-18

nixonix.title https://thehill.com/opinion/healthcare/568116-time-to-get-serious-about-uncovering-pandemics-origins00:26
Brainstormnixonix: From thehill.com: Time to get serious about uncovering the pandemic's origins | TheHill00:26
BrainstormNew from The Lancet (Online): [Articles] Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019: Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in [... want %more?] → https://is.gd/3KFsqw00:31
BrainstormUpdates for Syria: +70 cases (now 26479), +2 deaths (now 1942) since 22 hours ago — Tunisia: +1062 cases (now 626750), +120 deaths (now 22025), +4967 tests (now 2.4 million) since a day ago00:34
nixonix.title https://twitter.com/feldman_gil/status/1427709043842461706  israel, compare the two last graphs00:39
Brainstormnixonix: From twitter.com: Gil Feldman (@feldman_gil): "Here are some charts about the situation 👇" | nitter00:39
nixonix.title https://www.ft.com/content/572112fd-a713-4b0f-99be-bfcbf8506205  https://archive.is/W0CKN00:49
Brainstormnixonix: From www.ft.com: Become an FT subscriber to read | Financial Times00:49
nixonix^ Israel’s worrying fourth wave00:49
BrainstormNew from Eric Topol: @EricTopol: Mix and match vaccines, AZ then mRNA (@BioNTech_Group) achieves a very strong immune response against the Delta variant. This is the 1st report to look at mix vs Delta, specifically.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01891-2/fulltext @TheLancet → https://is.gd/RqGR7s00:53
nixonix"Early adoption does come with pitfalls: early versions of products may be buggy and/or prone to malfunction."00:54
nixonixthat leaked stolen (and altered) pfizer data claimed high share of damaged nanoparticles or mrna, if i recall00:55
nixonix"‘ unless the virus burns itself out’ ...Come on FT you can do better than that "00:56
nixonix> nixonix   maybe its dying00:57
nixonixnice to see there are other people with similar hypotheses...00:57
nixonix.title https://www.covboost.org.uk/about01:01
Brainstormnixonix: From www.covboost.org.uk: About COV-Boost | COV-Boost01:01
BrainstormNew from Eric Topol: @EricTopol: R to @EricTopol: The new reports adds on to a growing body of evidence about adenovirus-vector vaccine 1st, then mRNA 2nd dose, for a better immune response than from 2 doses of either (AZ + AZ or mRNA + mRNA). No data for benefit of reverse sequence (mRNA, then AZ) → https://is.gd/Y6ummo01:04
nixonix3rd dose in usa recommended after 8 months (6 in israel). roll-out order the same than original. moderna will be half-dose, according to topol01:24
nixonix.title https://twitter.com/EricTopol/status/142769922581963571301:24
Brainstormnixonix: From twitter.com: Eric Topol (@EricTopol): "Yet another step towards a pan-coronavirus vaccine (PCV) Discovery of 2C08, an antibody which is active against all major variants, including Delta, in experimental infection [...]01:24
nixonixGiven the germinal center B cell origin of 2C08, the binding of 2C08-related clones could be refined through somatic hypermutation, and their descendants could become part of the high-affinity memory B cell and long-lived plasma cell compartments that confer durable protective immunity01:24
BrainstormNew from Ars Technica: Science: Pandemic of unvaccinated continues to rage as states set new COVID records → https://is.gd/tNH8lV01:25
nixonix.title https://twitter.com/EricTopol/status/142767353699528294601:27
Brainstormnixonix: From twitter.com: Eric Topol (@EricTopol): "Good graph to show the states that are driving the 4th wave hospitalizations beyond prior limits https://www.nytimes.com/interactive/2021/08/17/us/covid-delta- [...]01:27
nixonixthat had interesting discussion. schools started already in AZ. cases going down in san francisco, they started demanding vax passport for bars01:27
nixonixRoche's Genentech warned that the "unprecedented" surge in demand for its arthritis drug Actemra, used to treat severely ill COVID-19 patients, has driven a global shortage that could last for months01:33
nixonixso it has some effect? twitter rumors been saying better antivirals coming early next year01:34
nixonixthat was il-6 blocker though, wasnt it01:35
BrainstormUpdates for Rwanda: +557 cases (now 80694), +8 deaths (now 977) since a day ago — Togo: +273 cases (now 18359), +5 deaths (now 170) since 22 hours ago — Angola: +233 cases (now 44972), +15 deaths (now 1118) since 20 hours ago — French Guiana: +246 cases (now 32426), +1 deaths (now 201), +1952 tests (now 343724) since a day ago01:36
BrainstormNew from The Atlantic: Why Wait 8 Months?: At this point, COVID-19 booster shots seem all but guaranteed for Americans. Last night, The New York Times and The Wall Street Journal reported that the White House plans to recommend a third dose of COVID-19 vaccine to most Americans who have already gotten two shots from Pfizer or Moderna. The news comes [... want %more?] → https://is.gd/nhgDbc01:36
nixonix.title https://www.biorxiv.org/content/10.1101/2021.08.13.456316v101:40
Brainstormnixonix: From www.biorxiv.org: Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates | bioRxiv01:40
nixonixthe troubled curevac's cv2cov v201:41
nixonixBoth CVnCoV and CV2CoV contain non-modified nucleotides, without pseudouridine or derivates, and CV2CoV has previously been shown to lead to higher antigen expression than CVnCoV in cell culture01:43
nixonixwell that sucks...01:44
nixonixWe immunized 18 cynomolgus macaques with two doses of 12 ug of lipid nanoparticle formulated CVnCoV, CV2CoV, or sham (N=6/group). CV2CoV induced substantially higher binding and neutralizing antibodies, memory B cell responses, and T cell responses as compared with CVnCoV.01:46
BrainstormNew from Eric Topol: @EricTopol: Last week I mentioned there was more to the US Delta breakthrough infections and hospitalizations (H) than apparent via the CDC website and other sources. Since then the @nytimes looked into ithttps://www.nytimes.com/2021/08/17/health/covid-vaccinated-infections.htmlStill looking for all US (H) data...... → https://is.gd/KgAR8D01:47
nixonixthats what ive been thinking, less symptoms in breakthrough cases, and often exposed vaccinated arent tested as easily, meaning more hidden cases among them01:50
BrainstormNew from Virological.org: Latest posts: Genomic Surveillance of SARS-CoV-2 in the State of Rio de Janeiro, Brazil: technical briefing: [Update information - Genomic surveillance of the state of Rio de Janeiro, Brazil, in the period between June, 24th, 2021 and July, 31th, 2021] Continuing  the Genomic Surveillance Program of the Rede Corona-ômica-RJ [... want %more?] → https://is.gd/7ewQl402:19
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Florida official calls on DeSantis to declare state of emergency: 'Our hospitals and our health care workers are overwhelmed' → https://is.gd/iuT5qe02:30
BrainstormUpdates for France: +36054 cases (now 6.5 million), +191 deaths (now 112970) since 22 hours ago — Bulgaria: +1405 cases (now 435940), +19 deaths (now 18395) since a day ago — United Kingdom: +20411 cases (now 6.3 million), +92 deaths (now 131223) since 22 hours ago — Netherlands: +1790 cases (now 1.9 million), +5 deaths (now 18074) since 22 hours ago03:03
BrainstormUpdates for Fr. Polynesia: +2164 cases (now 32705), +13 deaths (now 224) since a day ago — Suriname: +161 cases (now 26802), +4 deaths (now 689) since 22 hours ago03:41
BrainstormNew from The Indian Express: World: New Zealanders begin life in lockdown, Delta cases edge up → https://is.gd/RXoVxv03:54
BrainstormNew from The Indian Express: World: Britain urges halt to Myanmar clashes to allow vaccination → https://is.gd/uDioMd04:05
BrainstormUpdates for Egypt: +112 cases (now 285577), +5 deaths (now 16630) since a day ago — Germany: +4098 cases (now 3.8 million) since 15 hours ago04:30
BrainstormUpdates for United Kingdom: +20034 cases (now 6.3 million), +127 deaths (now 131265) since 21 hours ago — Netherlands: +1788 cases (now 1.9 million), +4 deaths (now 18075) since 21 hours ago — Canada: +2050 cases (now 1.5 million) since 21 hours ago — Australia: +251 cases (now 40331), +171890 tests (now 28.5 million) since 23 hours ago05:08
BrainstormUpdates for Belgium: +1741 cases (now 1.2 million), +44512 tests (now 18.1 million) since 23 hours ago05:32
twomoonhi IndoAnon kamu hebat05:33
twomoon=)05:33
BrainstormNew from The Indian Express: World: Overwhelmed by coronavirus, Cuba’s vaunted health system is reeling → https://is.gd/UPSCju06:01
twomoonACE2 triple decoy cracks me up06:09
twomoonthat really fools the heck outta the virus06:10
BrainstormUpdates for Bolivia: +1303 cases (now 483731), +37 deaths (now 18222), +8123 tests (now 2.2 million) since a day ago — Honduras: +1844 cases (now 321675), +56 deaths (now 8496), +3996 tests (now 933024) since 22 hours ago06:10
IndoAnontwomoon: huh?06:17
twomoonnevermind06:17
BrainstormNew from r/WorldNews: worldnews: Growing New Zealand Covid cluster linked to Sydney Delta outbreak → https://is.gd/8qz15x06:22
BrainstormNew from The Indian Express: World: Ecuador to give immune-weakened people third Covid-19 vaccine → https://is.gd/OGTlpb06:43
BrainstormUpdates for Texas, United States: +28206 cases (now 3.4 million), +99 deaths (now 54478) since a day ago — Reunion: +2919 cases (now 46754), +12 deaths (now 310) since 4 days ago — Nebraska, United States: +2676 cases (now 235075), +12 deaths (now 2302) since 4 days ago — Rio de Janeiro, Brazil: +4925 cases (now 1.1 million), +116 deaths (now 60771) since a day ago08:02
BrainstormUpdates for Mongolia: +1587 cases (now 186537), +5 deaths (now 889) since 22 hours ago — Venezuela: +967 cases (now 320922), +15 deaths (now 3830) since a day ago08:39
BrainstormNew from Politico: Vaccine data showing efficacy drop over time behind US booster shot strategy: Evidence gathered by the CDC showed a decline in the initial round of protection against COVID-19 infection that's coincided with a resurgence in cases driven by the more contagious Delta variant. → https://is.gd/MO2nhs09:00
BrainstormUpdates for Ghana: +1146 cases (now 112378), +15 deaths (now 945), +10850 tests (now 1.5 million) since a day ago09:04
BrainstormNew from r/Coronavirus: Daily Discussion Thread | August 18, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/5SSo3209:11
BrainstormUpdates for Seychelles: +291 cases (now 19186), +3 deaths (now 101) since 4 days ago — Bermuda: +52 cases (now 2715), +12615 tests (now 428834) since 4 days ago — N. Mariana Is.: +5 cases (now 219) since a day ago — Saint Lucia: +103 cases (now 6578), +418 tests (now 64015) since a day ago09:41
BrainstormNew from The Indian Express (Health): Health: Diabetes and Covid 19: Self-care tips to manage the condition amid pandemic → https://is.gd/OZx26909:53
BrainstormUpdates for Palestine: +836 cases (now 321867), +6149 tests (now 2.1 million) since a day ago — Lithuania: +646 cases (now 291412), +3 deaths (now 4461) since a day ago — Czechia: +299 cases (now 1.7 million), +90575 tests (now 34.8 million) since a day ago — Haiti: +76 cases (now 20685), +1 deaths (now 580), +827 tests (now 105516) since 12 hours ago10:31
BrainstormNew from Politico: Coronavirus: Pope urges world to get vaccinated against coronavirus → https://is.gd/2cjux010:46
BrainstormNew from BMJ: David Oliver: Were Nightingale units and fever hospitals ever workable responses to covid-19?: Research has found that around one in nine inpatients with covid-19 acquired it while in hospital.1 Much of the commentary on our national pandemic response included calls for patients with covid-19... → https://is.gd/O31qZm10:57
BrainstormNew from StatNews: Opinion: Waiving intellectual property rights would compromise global vaccination efforts: Embedding delicate mRNA vaccine molecules inside lipid nanoparticle shells at temperatures colder than Antarctica isn't as easy as following a recipe from Bon Appetit. → https://is.gd/ipg5h211:07
BrainstormUpdates for Kerala, India: +21613 cases (now 3.7 million), +127 deaths (now 18870) since a day ago — Armenia: +504 cases (now 235675), +3 deaths (now 4716) since a day ago — Goa, India: +115 cases (now 172683), +1 deaths (now 3177) since a day ago — Israel: +4806 cases (now 959129), +143166 tests (now 18.0 million) since 15 hours ago11:08
BrainstormUpdates for Russia: +20914 cases (now 6.7 million), +799 deaths (now 172909), +400000 tests (now 173.2 million) since 23 hours ago — Latvia: +180 cases (now 140505), +1 deaths (now 2566), +8537 tests (now 3.3 million) since 22 hours ago — Slovakia: +112 cases (now 393722), +1 deaths (now 12547) since 23 hours ago [... want %more?]11:33
BrainstormNew from ProPublica: Massachusetts Police Can Easily Seize Your Money. The DA of One County Makes It Near Impossible to Get It Back.: by Saurabh Datar and Shannon Dooling , WBUR ] If you’re reading this, we’d like to learn more about you . To help us better understand who we’re reaching, who we’re not reaching and how we can improve our [... want %more?] → https://is.gd/LXtqgr11:39
BrainstormNew from BMJ: Ivory Coast rolls out Ebola vaccine after first confirmed case since 1994: Health officials in the Ivory Coast are scrambling to vaccinate healthcare workers and trace all social contacts of the first case of the Ebola virus reported there in 25 years.An 18 year old woman... → https://is.gd/V2m2ia11:49
BrainstormUpdates for Austria: +1221 cases (now 671593) since a day ago — Libya: +2325 cases (now 289219), +12 deaths (now 3968), +8313 tests (now 1.4 million) since 21 hours ago — Finland: +673 cases (now 119320), +27823 tests (now 6.3 million) since 23 hours ago — Guinea: +2 deaths (now 295), +1394 tests (now 523699) since 21 hours ago12:10
-Bridgestorm- ⭕ Earthquake! Séisme! 7.1 Mi tremor, registered by PT, occurred 8 minutes ago (10:10:06 UTC), with a gibbous moon, Port-Olry, Vanuatu (-14.93, 166.94), ↓83 km likely felt 560 km away (in Luganville…) by 13200 people (earthquake.usgs.gov)12:18
BrainstormUpdates for Eq. Guinea: +38 cases (now 9010), +2041 tests (now 187519) since 3 days ago — Germany: +4310 cases (now 3.8 million) since 23 hours ago — Brunei: +29 cases (now 881), +2748 tests (now 182168) since 21 hours ago12:35
BrainstormNew from r/Coronavirus: Coronavirus: Texas school district makes masks part of dress code to get around Gov. Abbott's order → https://is.gd/7Eb04j12:53
specinginteresting13:12
specingperhaps dress codes will be abolished now :P13:12
BrainstormNew from PubMed: The animal origin of SARS-CoV-2: Trading of animals susceptible to bat coronaviruses is the likely cause of the COVID-19 pandemic. → https://is.gd/9ux10R13:15
BrainstormUpdates for Malaysia: +22242 cases (now 1.5 million), +225 deaths (now 13302) since 23 hours ago — Fiji: +653 cases (now 41830), +8 deaths (now 413), +1802 tests (now 354603) since 21 hours ago — Croatia: +524 cases (now 367933), +3 deaths (now 8291), +2412 vaccines (now 1.7 million) since a day ago — Laos: +381 cases (now 11029), +2769 tests (now 349664) since a day ago13:37
BrainstormNew from Politico: Cancer: Belgium to give booster coronavirus vaccines for immunocompromised → https://is.gd/3nZUru13:47
BrainstormNew from NPR: In A Message To Americans, Pope Francis Says Getting Vaccinated Is 'An Act Of Love': "Vaccination is a simple but profound way of promoting the common good and caring for each other, especially the most vulnerable," Pope Francis said in a message directed particularly at the Americas. → https://is.gd/5p31bB14:09
BrainstormUpdates for Zambia: +382 cases (now 203169), +6 deaths (now 3556), +6833 tests (now 2.2 million) since 21 hours ago — Iceland: +130 cases (now 9812), +4729 tests (now 926622) since a day ago14:39
BrainstormUpdates for Nepal: +2613 cases (now 739907), +42 deaths (now 10396) since a day ago — Switzerland: +3290 cases (now 747396), +7 deaths (now 10932), +22758 tests (now 9.4 million) since 23 hours ago — Madagascar: +13 cases (now 42832) since a day ago — Romania: +541 cases (now 1.1 million), +6 deaths (now 34365), +35044 tests (now 11.1 million) since a day ago15:04
BrainstormNew from Derek Lowe: @statnews: RT by @Dereklowe: Opinion: Embedding delicate mRNA vaccine molecules inside lipid nanoparticle shells at temperatures colder than Antarctica isn't as easy as following a recipe from Bon Appetit. https://buff.ly/3mieGfThttps://is.gd/AQv82n15:14
BrainstormNew from r/WorldNews: worldnews: Unvaccinated? Meet the Unsympathetic: Most inoculated Canadians indifferent to whether the non-jabbed get sick → https://is.gd/E8Xa5d15:25
BrainstormUpdates for Denmark: +1013 cases (now 333815), +160450 tests (now 79.0 million) since 12 hours ago — Bangladesh: +7248 cases (now 1.4 million), +172 deaths (now 24719), +41014 tests (now 8.5 million) since 22 hours ago — Brunei: +65 cases (now 946) since 2 hours ago — Qatar: +218 cases (now 229915), +6249 tests (now 2.4 million) since 23 hours ago15:29
BrainstormNew from NPR: A Pharmacist Is Being Charged With Selling COVID-19 Vaccine Cards For $10 On eBay: Tangtang Zhao, 34, allegedly sold 125 authentic Centers for Disease Control and Prevention (CDC) vaccination cards to 11 buyers in March and April. → https://is.gd/wIbP9C15:47
BrainstormUpdates for Azerbaijan: +4129 cases (now 377304), +20 deaths (now 5208), +17740 tests (now 4.3 million) since 23 hours ago — Serbia: +1497 cases (now 736313), +6 deaths (now 7183), +12818 tests (now 4.9 million) since a day ago — Iraq: +7992 cases (now 1.8 million), +71 deaths (now 19886), +41075 tests (now 13.9 million) since a day ago [... want %more?]16:06
BrainstormNew from Eric Topol: @EricTopol: Why is Delta so much more contagious than prior #SARSCoV2 variants?It achieves membrane fusion far more efficiently and fasterhttps://www.biorxiv.org/content/10.1101/2021.08.17.456689v1https://is.gd/7k3iQK16:31
BrainstormNew from NPR: COVID-19 Booster Shots Will Roll Out In September In The U.S.: People will be eligible for a booster shot eight months after their second dose of their vaccines from Pfizer or Moderna, according to the U.S. Department of Health and Human Services. → https://is.gd/9II9jE16:53
lastshellIsrael is doing after 6 months17:01
BrainstormUpdates for El Salvador: +2006 cases (now 92135), +8 deaths (now 2812) since a day ago — Portugal: +2983 cases (now 1.0 million), +17 deaths (now 17601) since a day ago — Kenya: +1506 cases (now 224400), +24 deaths (now 4378), +9840 tests (now 2.3 million) since 21 hours ago [... want %more?]17:02
BrainstormNew from Emma Hodcroft: @firefoxx66: I've much admiration for @TanjaStadler_CH, new head of the @SwissScience_TF (COVID-19 task force). 👏🏻👩🏻‍💻I welcome her expertise to help guide Switzerland through the coming autumn & winter, as cases are rising & many still need to be vaccinated. 🇨🇭 [... want %more?] → https://is.gd/jeVOMN17:04
BrainstormNew from Emma Hodcroft: @firefoxx66: R to @firefoxx66: As a woman & early career scientist, it's also fantastic to see her take on such a prominent role, particularly in Switzerland! ✊🏻♀️ So many women in Switzerland have contributed to pandemic efforts, it's important to see them at every level!#WomenInSTEM #WomenInScience → https://is.gd/cioI8W17:16
imaginarywhat are your stances on the booster shot news17:21
BrainstormNew from Reddit (test): Wednesday 18 August 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://is.gd/7I23aH17:27
BrainstormNew from Eric Topol: @EricTopol: Live imaging of covid spread and its prevention/takedown by neutralizing antibody, for which the Fc component is critical https://www.cell.com/immunity/fulltext/S1074-7613(21)00347-2#relatedArticles @ImmunityCP @justsaysinmice @YaleMedicine @YaleMicroPath @UMontreal @bjorkmanlab and collaborators → https://is.gd/iezNFu17:39
BrainstormUpdates for Kosovo: +2110 cases (now 120862), +4 deaths (now 2295) since a day ago — United Kingdom: +29011 cases (now 6.3 million), +803342 tests (now 259.2 million) since 23 hours ago18:04
imaginarysome relevant analysis maybe: https://twitter.com/CT_Bergstrom/status/142776735660068864618:06
BrainstormNew from Virological.org: Latest posts: Emergence of lineage B.1.621 in Latin America and the Caribbean:  Bernardo Gutierrez 1,2 , Sully Márquez 3 , Belén Prado-Vivar 3,4 , Mónica Becerra-Wong 3 , Fernanda Zurita 3 , Erika Muñoz 3 , Juan José Guadalupe 5 , Leandro Patiño 6 , Andrés Carazco-Montalvo 6 , Juan Carlos Fernández-Cadena 7 , Derly [... want %more?] → https://is.gd/8XewHq18:12
finely[m]https://www.statnews.com/2021/08/18/waiving-intellectual-property-rights-compromise-global-vaccination-efforts/18:57
finely[m]Obvious pharmaceutical company propaganda. COVAX  is a catastrophe for all of us. It was never going to provide enough doses for the less developed world.18:57
finely[m]We need a global vaccine effort equivalent to the Apollo/Manhattan projects. Waive patents on the technologies required to produce vaccine inputs too. Train enough people to just fucking do it.18:57
finely[m]The profits made by Pfzier alone this year are more than the cost of producing enough vaccine for 60% of the world, by one estimate.18:57
specingKarl Marx approves18:59
finely[m]Not sure Marx ever said anything about IP. I bet he would have a lot to say about publicly funded research being stolen by multinationals  to make records profits at the expense of millions of lives and livelihoods.19:04
specingyep19:06
specingIt's actually not stolen, though. It's bought19:06
specingthey buy the research results for pennies and sell it onwards19:06
BrainstormNew from StatNews: Opinion: Booster shots alone won’t protect immunocompromised people from Covid-19: Immunocompromised people "should be counseled to maintain precautions to help prevent Covid-19," says the FDA. This is where I lose sleep. Their health depends on far more than a booster… → https://is.gd/7jZJVW19:06
BrainstormUpdates for Moldova: +485 cases (now 263074), +8 deaths (now 6328), +6385 tests (now 1.5 million) since 23 hours ago — Spain: +11956 cases (now 4.7 million), +144 deaths (now 82883) since 22 hours ago — Morocco: +9703 cases (now 782097), +103 deaths (now 11345), +56099 tests (now 8.5 million) since 22 hours ago [... want %more?]19:07
finely[m]Sure the techniques are licenced legally. The question is should these companies make extranormal profits when they have taken none of risk in funding decades of basic research.19:12
finely[m]Quite aside from the question of who cares about protecting corrupt and untrustworthy organisations at the expense of lives?19:12
BrainstormNew from FDA Press Releases: Joint Statement from HHS Public Health and Medical Experts on COVID-19 Booster Shots: Public health and medical experts from the U.S. Department of Health and Human Services released a statement on the Administration’s plan for COVID-19 booster shots for the American people. → https://is.gd/eP6xo119:17
finely[m]This quote from the article also admits waiving IP could result in extra doses.19:18
finely[m]"And because negotiations surrounding the WTO waiver, which began this summer, could take until December before they are completed, it wouldn’t be until well into 2023 or later that any additional doses would become available."19:18
finely[m]Yep, they were very effective at fucking us all.19:19
BrainstormNew from Eric Topol: @EricTopol: R to @EricTopol: These are very limited windows to the US Delta wave. Where are the data for the ~90,000 patients currently hospitalized w/r to vaccination status, vaccine, time from vaccination, age, demographics, comorbidites? All of this exists in the patient charts. We can and must do better → https://is.gd/O2t0gh19:28
BrainstormUpdates for Cuba: +8666 cases (now 545275), +84 deaths (now 4240), +45939 tests (now 7.3 million) since 22 hours ago — Jamaica: +730 cases (now 59188), +3100 tests (now 523891) since 23 hours ago19:44
BrainstormNew from StatNews: Pharma: STAT+: WHO urges Roche to ensure equitable access of Covid-19 treatment amid global shortage → https://is.gd/9PpdtC19:49
BrainstormNew from Eric Topol: @EricTopol: Israel now ranks 3rd highest case/capita countries in the world w/ >1M population (after Georgia, Cuba) and heading due northThis should not provide any comfort to the US vs Delta with much less fully vaccinated (12% points) of total population @OurWorldInData → https://is.gd/rLLfAj20:01
BrainstormUpdates for South Africa: +14727 cases (now 2.6 million), +243 deaths (now 78236), +66645 tests (now 15.8 million) since 22 hours ago — Cyprus: +433 cases (now 110098), +3 deaths (now 467) since 21 hours ago20:02
BrainstormNew from CIDRAP: COVID-19 Scan for Aug 18, 2021: Refugee mental health during pandemic Remdesivir, dexamethasone for COVID → https://is.gd/y7pIs920:23
JbwncsterBiden to require nursing homes get staff vaccinated or lose federal funds https://www.cnn.com/2021/08/18/politics/nursing-homes-federal-funding/index.html20:39
BrainstormUpdates for North Macedonia: +1077 cases (now 164529), +15 deaths (now 5589) since 22 hours ago — Eswatini: +769 cases (now 38030), +10 deaths (now 961) since 22 hours ago — Albania: +477 cases (now 137075), +3 deaths (now 2471) since a day ago — Cabo Verde: +84 cases (now 34529) since 22 hours ago20:40
BrainstormNew from WebMD: TSA Extends Mask Mandate for U.S. Travelers to January: Amid a surge in coronavirus cases fueled by the highly contagious Delta variant, a mask mandate for travelers and employees on U.S. airline flights and public transportation will be extended until Jan. 18. → https://is.gd/t2KzHP20:55
LjLanyone know whether this is plausible? https://twitter.com/CT_Bergstrom/status/142776735780860313921:00
LjL%title21:00
BrainstormLjL: From twitter.com: Carl T. Bergstrom (@CT_Bergstrom): "2. While I 've not spent enough time with the raw data to be willing to make absolute claims, I suspect this apparent decline may be an artifact; I think we can [...]21:00
LjL%wik Simpson's paradox21:00
BrainstormLjL, from English Wikipedia: Simpson's paradox, which also goes by several other names, is a phenomenon in probability and statistics in which a trend appears in several groups of data but disappears or reverses when the groups are combined. This result is often encountered in social-science and medical-science statistics, and is [... want %more?] → https://en.wikipedia.org/wiki/Simpson's_paradox21:00
LjLi don't really understand this21:00
LjLor i might sort of understand the Wikipedia example but not sure how it translates here21:01
BrainstormUpdates for Benin: +1118 cases (now 10183), +6 deaths (now 119) since 4 days ago — Sint Maarten: +44 cases (now 3271), +1 deaths (now 42) since a day ago — Guernsey: +19 cases (now 1123) since 22 hours ago — Cayman Is.: +5 cases (now 656) since 4 days ago21:05
BrainstormUpdates for Lebanon: +1689 cases (now 586585), +5 deaths (now 7993) since 22 hours ago — Malawi: +396 cases (now 58861), +14 deaths (now 2012) since a day ago — Turkey: +6648 cases (now 6.1 million), +295206 tests (now 72.7 million) since 15 hours ago — US Virgin Is: +118 cases (now 5413) since a day ago21:29
de-facto.title https://www.nejm.org/doi/full/10.1056/nejmc210391621:32
Brainstormde-facto: From www.nejm.org: Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 | NEJM21:32
de-factoreally interesting data for Moderna antibody half lifes at https://www.nejm.org/doi/suppl/10.1056/NEJMc2103916/suppl_file/nejmc2103916_appendix.pdf21:35
LjLde-facto, do you understand the effect i mentioned above?21:37
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 ( https://www.zotero.org/groups/covid_links/items/GSNF9IVD )21:41
de-factoLjL, well yeah as all parameters in epidemics it has to be analyzed as comparison of incidence over time separated by age groups21:43
de-factoe.g. accumulating together all age groups in one big bucket will result in misinterpretations, especially when highly age dependent parameters (IFR, vaccination rate, probably even incidence itself) are working against each others21:45
LjLbut it really beats me how you can have >85% efficacy in both groups but when you put them together it becomes 67%21:45
LjLi soooort of got it by reading the article on Simpson's paradox on the Simple English wikipedia ;(21:46
LjLnot that english is the issue21:46
de-factoalso these groups are differently weighted in the "all" category, e.g. there is a distribution of age21:52
BrainstormNew from WebMD: COVID-19 Booster Shots to Start in September: Officials: Booster shots to ramp up protection against COVID-19 infection are slated to begin the week of Sept. 20, the Biden administration announced at a press briefing Wednesday. → https://is.gd/RJVCLB22:01
de-factohttps://www.covid-datascience.com/post/israeli-data-how-can-efficacy-vs-severe-disease-be-strong-when-60-of-hospitalized-are-vaccinated22:06
de-factolook at that table in detail: all ages put together give 1 - (301/5634634)/(214/1302912) = 0,674822:06
de-factobut 290/301 = 0.9635 breakthroughs happened in >50 yo minority 186078/1116834 = 0,1666 hence the breakthrough attack rate will heavily overrepresent the elderly in all age cohort22:06
de-factohence elderly vaccinated must be compared to elderly non-vaccinated to get appropriate efficacy data22:07
twomoonhi de-facto22:28
BrainstormUpdates for Guatemala: +4650 cases (now 422270), +54 deaths (now 11273) since 20 hours ago — Ethiopia: +985 cases (now 291803), +10 deaths (now 4505) since a day ago — Guinea-Bissau: +83 cases (now 5206), +4 deaths (now 94) since 2 days ago — Canada: +1929 cases (now 1.5 million) since 22 hours ago22:32
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Covid-19 Data Science ( https://www.zotero.org/groups/covid_links/items/Z9IT3E8E )22:53
BrainstormNew from Eric Topol: @EricTopol: Step-by-step, towards a pan-coronavirus vaccine. This one via individuals with the original SARS (in 2003) getting a #SARSCoV2 mRNA vaccine, neutralizes all variants of concern and more @NEJM @NUSingapore @dukenus https://www.nejm.org/doi/full/10.1056/NEJMoa2108453?query=featured_homehttps://is.gd/rY4THe23:05
twomoonzotero is so cool for organizing stuff23:07
LjL↑ that looks like a very encouraging thing (the stuty Topol linked)23:16
LjLmaybe injecting the SARS-1 S-protein and the SARS-2 one as well (or their mRNA) would cause the development of such antibodies?23:17
twomoonwuuuut. the old SARS virus .....23:18
twomoonone day we'll be able to predict conformations of the S-Protein that could be dangerous and make a pan vaccine with all of them23:22
LjLyes, but it sounds like we might be able to elicit these antibodies quicker than we can figure out how to do that23:22
twomoonof course the memory system of our immune system may run out of mem23:22
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors ( https://www.zotero.org/groups/covid_links/items/QWEHSW6U )23:28
TurboTechHey Gang.23:29
TurboTechPardon my french, but we are about to start seeing a shitload of death.23:30
TurboTechI think 30% of our patient Covid load is on ventilators.23:30
de-factoone of six will end in grave?23:32
BrainstormUpdates for Curacao: +65 cases (now 14751), +2131 tests (now 216163) since a day ago23:34
LjL:(23:37
imaginaryTurboTech: where are you located?23:37
LjLimaginary, Texas23:39
imaginarydamn :(23:39
binTurboTech: yeah and ICUs are out of beds I was reading23:44
BrainstormNew from Ars Technica: Science: What to know about the US COVID booster plan—and why WHO hates it → https://is.gd/8aX8JF23:48
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents ( https://www.zotero.org/groups/covid_links/items/KRCDB6VT )23:53
twomoonwhere is turbotech?23:57
twomoonoh Tejas23:57
twomoonyeah i read about ICU capacity being nearly full two days ago23:57
BrainstormNew from Johnson&Johnson: (news): Statement on Boosting with the Johnson & Johnson COVID-19 Vaccine → https://is.gd/Fjm1op23:59

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