LjL | that's a bit of a saying-nothing press release | 00:01 |
---|---|---|
LjL | "boosters. we know people are talking about them." | 00:01 |
de-facto | TurboTech, how is your GI tract, feel better again? | 00:08 |
Brainstorm | New from https://covid19.specops.network : ljl-covid: Add news about the US planning a booster shot → https://is.gd/mSbWoI | 00:09 |
Brainstorm | Updates for Rwanda: +33 cases (now 80727), +10299 tests (now 2.3 million) since 22 hours ago | 00:11 |
TurboTech | Sorry guys, I got lost. LOL | 00:31 |
Brainstorm | New from The Lancet (Online): [Department of Error] Department of Error: Yu L-M, Bafadhel M, Dorward J, et al. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet 2021; published online Aug 10. [... want %more?] → https://is.gd/OMuPpf | 00:31 |
TurboTech | My GI tract is fine. Must have been the leaf spinach. I tested last night via PCR and was negative. | 00:31 |
TurboTech | So, I am good for now. And that means I have not had it in the last few months either because there is residual | 00:32 |
LjL | was Pfizer/BioNTech officially running a Delta-specific vaccine trial yet? they announced it should be in August but i'm not sure i see it on clinicaltrials or wherever, want to make sure it's happening since now they've convinced the US to get a third shot of the original instead | 00:33 |
LjL | TurboTech, uh afaik you *may* still test positive after months but most people test negative after 30 days or so | 00:33 |
LjL | unless you crank the ct way up i guess maybe | 00:34 |
TurboTech | By the time they get the vaccine for the variant most people will have had it. | 00:34 |
TurboTech | I should Run IgM, but I do not have access to those reagents. | 00:35 |
TurboTech | Every patient I have run who came back after being discharged 30 days or longer has still shown positive. | 00:35 |
Brainstorm | Updates for Ivory Coast: +253 cases (now 52836), +4 deaths (now 369) since a day ago — Syria: +75 cases (now 26554), +5 deaths (now 1947) since a day ago — Monaco: +19 cases (now 3099) since a day ago | 00:36 |
LjL | sigh | 00:42 |
Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: We keep getting closer to discovering /defining antibodies that will take down the entire beta coronavirus family, which can be used as a template for universal vaccines. I don't understand why we are futzing around with variant-specific vaccines when this could be #1 priority? → https://is.gd/gGFDQN | 00:42 |
de-facto | good to hear you are feeling better TurboTech | 00:50 |
de-facto | LjL, maybe this one? not sure https://clinicaltrials.gov/ct2/show/NCT05004181 | 00:51 |
LjL | ah thanks de-facto | 00:53 |
Juerd | "Closer to discovering" - er. | 00:53 |
Juerd | Is that how discoveries work? | 00:53 |
LjL | Juerd, sometimes. see previous <Brainstorm> New from Eric Topol: @EricTopol: Step-by-step, towards a pan-coronavirus vaccine. This one via individuals with the original SARS (in 2003) getting a #SARSCoV2 mRNA vaccine, neutralizes all variants of concern and more @NEJM @NUSingapore @dukenus https://www.nejm.org/doi/full/10.1056/NEJMoa2108453?query=featured_home → https://is.gd/rY4THe | 00:54 |
Juerd | But with actual discoveries, you never know how close you are, right? | 00:54 |
LjL | they found individuals who had SARS inoculated with BNT develop antibodies that take out a wide family of coronaviruses | 00:54 |
* LjL shrugs | 00:55 | |
Juerd | Either you've discovered it already or not yet, and if you haven't, then how could you possibly know how far off you are... | 00:55 |
LjL | i disagree, but anyway what i posted kinda says they already have | 00:55 |
Juerd | Which is really cool by the way | 00:55 |
LjL | they may not "take down the entire beta coronavirus family", but they sure might handle what we have now | 00:55 |
LjL | endlessly chasing variants would be depressing | 00:56 |
Juerd | Only if @EricTopol is right about "the T cell narrative" being "negated", which at least the virologists of TWiV seem to disagree about (relevant episode: https://www.microbe.tv/twiv/twiv-791/) | 00:57 |
Juerd | (52:10 and on, specific highlight at 52:55) | 00:59 |
LjL | i don't know why everything has to be framed in terms of "narratives" like the people who think T-cells play a role are trying to tell us a story | 01:09 |
de-facto | huh? dont they all look at T-cell responses to the vaccines? | 01:11 |
de-facto | surely they would not do that if they thought it would be irrelevant | 01:11 |
de-facto | they react to smaller fractions of the epitopes, hence are not as easily evaded as antibody affinity | 01:12 |
LjL | well i've definitely read opinions after the Israel "antibodies waning" indications that said, see, T-cells are not playing much role, it's the antibodies that are a clear correlate of protection | 01:12 |
LjL | and i guess Topol is of that camp | 01:13 |
de-facto | well its two different arms of the immune system, T-cells and B-cells | 01:13 |
Brainstorm | New from Politico: Study shows BioNTech/Pfizer vaccine loses efficacy over time: But researchers say the mRNA shot for COVID-19 remains highly effective against the Delta variant. → https://is.gd/vTZub8 | 01:14 |
Brainstorm | Updates for Argentina: +6487 cases (now 5.1 million), +247 deaths (now 109652), +103636 tests (now 21.0 million) since a day ago — Bahrain: +127 cases (now 271257), +1 deaths (now 1385) since a day ago — Somalia: +1 cases (now 16400), +2666 tests (now 186064) since a day ago | 02:03 |
Brainstorm | Updates for Netherlands: +2617 cases (now 1.9 million), +7 deaths (now 18081) since 23 hours ago — Ukraine: +1472 cases (now 2.3 million), +44 deaths (now 54792) since 23 hours ago — Egypt: +123 cases (now 285700), +8 deaths (now 16638) since 22 hours ago — Guyana: +120 cases (now 23795), +5 deaths (now 587) since 23 hours ago | 02:40 |
Brainstorm | New from r/WorldNews: worldnews: Qantas makes COVID-19 vaccinations mandatory for all of its workers → https://is.gd/XM1lkc | 02:50 |
Brainstorm | New from r/WorldNews: worldnews: Jabbed adults infected with Delta ‘can match virus levels of unvaccinated’ → https://is.gd/CIb9yf | 03:22 |
Brainstorm | Updates for Tunisia: +2843 cases (now 629593), +134 deaths (now 22159), +24382 tests (now 2.4 million) since a day ago | 03:30 |
Brainstorm | New from Eric Topol: @EricTopol: Now >91,000 Americans hospitalized, 70% of the peak 3rd wave (when there were no vaccines). At least 75,000 of these would have been avoided with vaccination. This is the story of the US 4th wave. → https://is.gd/zQ23WL | 03:54 |
Brainstorm | Updates for Paraguay: +199 cases (now 457222), +19 deaths (now 15492) since 22 hours ago | 04:07 |
Brainstorm | New from Eric Topol: @EricTopol: Now leading the world in covid cases/capita(the US state with the lowest vaccination rate) → https://is.gd/RQltpn | 04:15 |
Brainstorm | Updates for South Korea: +2151 cases (now 230808), +13 deaths (now 2191) since 23 hours ago — France: +16124 cases (now 6.6 million), +62 deaths (now 113066) since 21 hours ago — Netherlands: +2100 cases (now 1.9 million), +5 deaths (now 18082) since 21 hours ago — Canada: +2174 cases (now 1.5 million) since 23 hours ago | 05:09 |
Brainstorm | Updates for Mexico: +28953 cases (now 3.2 million), +940 deaths (now 250469) since a day ago | 05:34 |
Brainstorm | New from The Indian Express: World: Vaccine effectiveness against infection may wane, CDC study → https://is.gd/29xnzq | 05:51 |
Brainstorm | Updates for Belgium: +2746 cases (now 1.2 million), +6 deaths (now 25305), +51852 tests (now 18.1 million) since a day ago — Honduras: +1950 cases (now 323625), +31 deaths (now 8527), +5304 tests (now 938328) since 23 hours ago — Germany: +9877 cases (now 3.9 million) since 17 hours ago | 05:59 |
Brainstorm | New from r/WorldNews: worldnews: Australia's Qantas to make vaccines mandatory for staff → https://is.gd/aN2s4q | 06:12 |
Brainstorm | New from r/WorldNews: worldnews: COVID: WHO establishes new scientific group to examine origins of coronavirus → https://is.gd/3UEJOk | 06:22 |
twomoon | has anyone ever experienced anosmia before ? | 06:25 |
twomoon | i have, at least 10 times i would say | 06:25 |
Brainstorm | New from Eric Topol: @EricTopol: New large UK study confirms attrition of @Pfizer vaccine effectiveness vs Delta infections over time https://www.bloomberg.com/news/articles/2021-08-18/covid-vaccines-are-less-effective-against-delta-in-u-k-study "By roughly 4 1/2 months after the 2nd dose, Pfizer’s shot will probably be about on par with Astra’s at [... want %more?] → https://is.gd/MmMpUL | 06:33 |
Brainstorm | Updates for Palestine: +753 cases (now 322620), +2 deaths (now 3627), +6463 tests (now 2.1 million) since 20 hours ago | 06:36 |
Brainstorm | New from The Indian Express: World: Israel, once the model for beating Covid-19, faces new surge of infections → https://is.gd/FlVeJT | 06:55 |
Brainstorm | New from The Indian Express: World: First resistance to Taliban rule tests Afghanistan’s uncertain future → https://is.gd/GU3KDG | 07:27 |
Brainstorm | Updates for England, United Kingdom: +28390 cases (now 5.5 million), +86 deaths (now 115295) since 23 hours ago — Iowa, United States: +5697 cases (now 392970), +16 deaths (now 6226) since 5 days ago — Parana, Brazil: +7338 cases (now 1.4 million), +103 deaths (now 36687) since 23 hours ago — Mexico City, Mexico: +5303 cases (now 855664), +81 deaths (now 36823) since 23 hours ago | 07:39 |
frtnx_ | %help | 08:06 |
Brainstorm | frtnx_: Hi, I am LjL's bot! Say %modules or %commands to me in private to see my features. | 08:06 |
frtnx_ | %commands | 08:07 |
Brainstorm | frtnx_, all exposed commands: act, anagrams, ask, bible, book, bug, commands, count, dick, echo, evaluate, geo, grammar, greet, help, language_code, language_identify, languages, last, link_get, link_put, lojban, modules, more, morphology, onelook, phonology_change, ping, pronunciation, search, seen, spell, spell2, stock, subscribe [... want %more?] (try %help <command>, or %modules for a directory) | 08:07 |
frtnx_ | %help geo | 08:08 |
Brainstorm | frtnx_, no documentation available for this command. | 08:08 |
frtnx_ | %cases | 08:08 |
Brainstorm | frtnx_: Sorry, not found. Either there aren't cases, or it's under a different name. | 08:08 |
frtnx_ | %cases Zimbabwe | 08:08 |
Brainstorm | frtnx_: Zimbabwe has had 121498 confirmed cases (0.8% of all people) and 4181 deaths (3.4% of cases) as of 5 hours ago. 1.2 million tests were done (10.1% positive). 2.1 million were vaccinated (14.2%). +452 cases, +25 deaths since 22 hours ago. See https://offloop.net/covid19/?default=Zimbabwe | 08:09 |
Brainstorm | frtnx_: If you know of an official or otherwise good site for data about Zimbabwe, with a reasonably short URL, please %tell LjL about it. | 08:09 |
weechat_ | %cases Vietnam | 08:09 |
Brainstorm | weechat_: Vietnam has had 302101 confirmed cases (0.3% of all people) and 6770 deaths (2.2% of cases) as of 14 hours ago. 15.3 million tests were done (2.0% positive). 13.9 million were vaccinated (14.4%). +8800 cases, +298 deaths since 23 hours ago. See https://offloop.net/covid19/?default=Vietnam | 08:09 |
Brainstorm | weechat_: If you know of an official or otherwise good site for data about Vietnam, with a reasonably short URL, please %tell LjL about it. | 08:09 |
frtnx_ | %cases south africa | 08:10 |
Brainstorm | frtnx_: South Africa has had 2.6 million confirmed cases (4.5% of all people) and 78377 deaths (3.0% of cases) as of 10 hours ago. 15.8 million tests were done (16.8% positive). 7.5 million were vaccinated (12.7%). +14727 cases, +243 deaths, +66645 tests since 22 hours ago. See https://offloop.net/covid19/?default=South%20Africa | 08:10 |
Brainstorm | frtnx_: If you know of an official or otherwise good site for data about South Africa, with a reasonably short URL, please %tell LjL about it. | 08:10 |
Brainstorm | Updates for Mongolia: +1875 cases (now 188412), +2 deaths (now 891) since a day ago — Venezuela: +1005 cases (now 321927), +14 deaths (now 3844) since a day ago | 08:41 |
Brainstorm | Updates for Anguilla: +17 cases (now 154) since 2 days ago | 08:59 |
Brainstorm | New from r/Coronavirus: Daily Discussion Thread | August 19, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/a4Xd4m | 09:02 |
Brainstorm | New from r/WorldNews: worldnews: WHO concerned about COVID-19 in Afghanistan as jabs slow → https://is.gd/ErVuYq | 09:56 |
Brainstorm | Updates for Czechia: +212 cases (now 1.7 million), +83265 tests (now 34.9 million) since 23 hours ago | 10:08 |
Brainstorm | New from Emma Hodcroft: @firefoxx66: Just signal boosting - if you saw some tweets yesterday about AY.3 - note that AY.3 has had some classifications issues recently, with assignments changing frequently, so need to be careful interpreting analyses.The pandemic is real-time; so is scientific effort! Not easy! → https://is.gd/x6xtAp | 10:17 |
Brainstorm | New from StatNews: Opinion: A natural pandemic has been terrible. A synthetic one would be even worse: The emergence of SARS-CoV-2 may well have been a natural spillover event. But it should be a stark reminder that preparations should be made for an even worse-case scenario of… → https://is.gd/4AFQK6 | 10:59 |
Brainstorm | New from Emma Hodcroft: @firefoxx66: The evidence we have at the moment suggests the vaccines are continuing to provide good protection against hospitalization & death.As long as that's the case, is it fair to recommend "just in case" boosters that take vaccines away from unvaccinated? #VaccineEquity → https://is.gd/6tLWrS | 11:10 |
Brainstorm | Updates for Philippines: +14508 cases (now 1.8 million), +258 deaths (now 30881) since a day ago — Punjab, Pakistan: +1336 cases (now 376252), +21 deaths (now 11455) since a day ago — Khyber Pakhtunkhwa, Pakistan: +770 cases (now 154606), +18 deaths (now 4714) since a day ago — Armenia: +559 cases (now 236234), +11 deaths (now 4727) since a day ago | 11:10 |
Brainstorm | New from BMJ: Covid-19: How many variants are there, and what do we know about them?: AlphaConsidered a variant of concern by the World Health Organization, alpha was first identified in Kent in the UK in September 2020 and drove the UK’s second wave.While it was first thought that... → https://is.gd/7sLwMZ | 11:55 |
Brainstorm | Updates for El Salvador: +281 cases (now 92416), +32483 vaccines (now 3.3 million), +2472 tests (now 1.2 million) since 18 hours ago — Hong Kong: +5 cases (now 12048), +66138 vaccines (now 3.8 million) since 23 hours ago — Timor-Leste: +17 cases (now 13172), +20693 vaccines (now 348548) since 22 hours ago | 12:00 |
Brainstorm | New from EMA: What's new: PIP: Opinion/decision on a Paediatric investigation plan (PIP): Veklury,remdesivir, decision type: , therapeutic area: , PIP number: P/0338/2021 → https://is.gd/DGSmXW | 12:03 |
Brainstorm | New from BMJ: Covid-19: How Kerala kept itself above water in India’s devastating second wave: India’s first confirmed case of covid-19 was detected in the southern state of Kerala on 27 January 2020. Despite being one of the worst affected states—with over three million recorded cases, a... → https://is.gd/RgvGzE | 12:14 |
Brainstorm | New from BMJ: Aducanumab, amyloid, and culture wars: Those who thought that the US Food and Drug Administration (FDA) was a conservative regulator which maintained a high bar have been shocked by its approval of the anti-amyloid antibody... → https://is.gd/vRCDh4 | 12:25 |
Brainstorm | New from BMJ: The BMJ Awards 2021: Critical care team of the year: Post-Intensive Care Unit Presentation Screen tool: covid-19 and beyondAbout half of the 156 000 patients who survive critical care every year experience post-intensive care syndrome: marked physical,... → https://is.gd/OL7WJ1 | 12:35 |
Brainstorm | Updates for Finland: +866 cases (now 120186), +20428 tests (now 6.3 million) since 19 hours ago — Slovenia: +382 cases (now 262571), +2 deaths (now 4438) since 22 hours ago | 12:37 |
Brainstorm | New from Scientific American: Masks Are a Must-Have to Go Back to School during the Delta Variant Surge: Young students physically distancing and wearing masks return to school as in-person classroom teaching reopens in Sonoma County, California. → https://is.gd/G0OBCq | 12:46 |
SpearRaven | my favourite covid locked down track -- https://www.youtube.com/watch?v=XonFZjuyc6E | 12:56 |
Brainstorm | New from ECDC: ECDC: Data for the maps in support of the Council Recommendation on a coordinated approach to the restriction of free movement in response to the COVID-19 pandemic in the EU/EEA → https://is.gd/o2qmzJ | 13:07 |
Brainstorm | Updates for Malaysia: +22948 cases (now 1.5 million), +178 deaths (now 13480) since a day ago — Belarus: +1355 cases (now 465210), +12 deaths (now 3649) since 22 hours ago — Austria: +1226 cases (now 672819), +3 deaths (now 10760) since a day ago — Fiji: +781 cases (now 42611), +8 deaths (now 421), +1400 tests (now 356003) since a day ago | 13:39 |
Brainstorm | Updates for Romania: +595 cases (now 1.1 million), +14 deaths (now 34379), +32708 tests (now 11.1 million) since 22 hours ago — Nepal: +2321 cases (now 742228), +33 deaths (now 10429) since 22 hours ago | 14:04 |
Brainstorm | New from ECDC: Data on the weekly subnational 14-day notification rate of new COVID-19 cases: The downloadable data file contains information on the 14-day notification rate of new cases per 100 000 inhabitants for COVID-19 by day and subnational region. Each row contains the corresponding data for a certain epidemiological week and per subnational [... want %more?] → https://is.gd/9OE13H | 14:11 |
Brainstorm | Updates for Switzerland: +2790 cases (now 750186), +22580 tests (now 9.5 million) since 23 hours ago — Ghana: +550 cases (now 112928), +4937 tests (now 1.5 million) since a day ago — Afghanistan: +37 cases (now 152448), +7 deaths (now 7054), +246 tests (now 747442) since a day ago | 14:29 |
Brainstorm | New from r/WorldNews: worldnews: Climate change will disrupt supply chains much more than Covid → https://is.gd/l0fm5P | 14:33 |
Brainstorm | New from Reddit (test): China_Flu: British study shows COVID-19 vaccine efficacy wanes under Delta → https://is.gd/irk7NM | 14:44 |
Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: Link to the preprint https://www.ndm.ox.ac.uk/files/coronavirus/covid-19-infection-survey/finalfinalcombinedve20210816.pdf and better graph than in preprint to show the effect of time https://www.ft.com/content/49641651-e10a-45f6-a7cc-8b8c7b7a9710 by @hannahkuchler @jburnmurdoch @FT → https://is.gd/rnNR9Y | 14:55 |
Brainstorm | New from Eric Topol: @EricTopol: Front page coverage today, with mention of new booster study that restored vaccine effectiveness vs infection in first group who received them (age > 60) https://www.nytimes.com/2021/08/18/world/middleeast/israel-virus-infections-booster.html?searchResultPosition=1 by @IKershner → https://is.gd/oUAvPs | 15:05 |
Brainstorm | Updates for Denmark: +751 cases (now 334566), +147972 tests (now 79.2 million) since 23 hours ago | 15:06 |
Brainstorm | New from Eric Topol: @EricTopol: A summary table of the studies that have assessed mRNA vaccine effectiveness (VE) for Delta infections, updated with reports from yesterday, overall in line with estimate ~50-60%; *does not pertain* to high VE for hospitalizations or deaths → https://is.gd/YvcQFt | 15:27 |
Brainstorm | Updates for Vietnam: +10510 cases (now 312611), +380 deaths (now 7150) since 21 hours ago — Bangladesh: +6566 cases (now 1.4 million), +159 deaths (now 24878) since a day ago | 15:31 |
Brainstorm | New from ScienceNews: How coronavirus vaccines still help people who already had COVID-19: Coronavirus vaccines give the immune system of previously infected people a boost, probably giving those people better protection against new variants. → https://is.gd/4WKIrW | 15:38 |
Brainstorm | New from Emma Hodcroft: @firefoxx66: R to @firefoxx66: As some have pointed out: vaccinating now won't stop cases rising immediately. Incredibly frustrating to think we didn't have to be facing down tough choices (again) had we pushed vaccines earlier.But to benefit from them later, we must start now. → https://is.gd/tpig0s | 15:49 |
Brainstorm | Updates for Serbia: +1656 cases (now 737969), +5 deaths (now 7188), +12869 tests (now 4.9 million) since a day ago — Iraq: +8012 cases (now 1.8 million), +72 deaths (now 19958), +40653 tests (now 13.9 million) since a day ago — Kenya: +1263 cases (now 225663), +26 deaths (now 4404), +8680 tests (now 2.3 million) since 23 hours ago | 16:08 |
Brainstorm | New from Eric Topol: @EricTopol: Emphasizing Delta's high risk of pre-symptomatic transmission https://www.nature.com/articles/d41586-021-02259-2 @Nature https://www.medrxiv.org/content/10.1101/2021.08.12.21261991v1 note graphs unvaccinated, vaccinated, prior to symptom onset and comparison w/ ancestral strain → https://is.gd/uHghKJ | 16:21 |
Brainstorm | Updates for Zambia: +384 cases (now 203553), +8 deaths (now 3564) since a day ago — Azerbaijan: +3614 cases (now 380918), +23 deaths (now 5231), +15786 tests (now 4.3 million) since a day ago — Gibraltar: +13 cases (now 5261), +986 tests (now 328086) since a day ago | 16:33 |
Lyra2021 | anyone here | 16:38 |
Brainstorm | New from Shane Crotty: @profshanecrotty: A short chat about COVID vaccine boosters…and vanilla.🙂https://www.kpbs.org/podcasts/kpbs-midday-edition/2021/aug/18/us-health-officials-call-covid-booster-shots/ → https://is.gd/WPZvBu | 16:55 |
Lyra2021 | The Panjshir Resistance taked Charikar,the capital of Parwan Province in Afghanistan on 17 August.(Wikipedia-zh) | 17:01 |
pwr22 | Lyra2021: Hi, this is a covid-19 / SARS-COV-2 channel / room | 17:02 |
Lyra2021 | oh,sorry() | 17:03 |
Brainstorm | New from LitCovid: (news): Successful Treatment of Persistent Coronavirus Disease 2019 Infection in a Patient With Hypogammaglobulinemia With REGN-COV2: A Case Report. → https://is.gd/8HeZee | 17:06 |
Brainstorm | Updates for Myanmar: +2590 cases (now 365759), +159 deaths (now 13945), +23491 tests (now 3.4 million) since 23 hours ago | 17:10 |
Brainstorm | Updates for Kosovo: +2236 cases (now 123098), +8 deaths (now 2303) since 23 hours ago — Cuba: +8972 cases (now 554247), +79 deaths (now 4319), +48651 tests (now 7.3 million) since 21 hours ago | 17:35 |
LjL | sigh, the awful combination of people not knowing facts about the current situation (despite writing a very long explanation of it), and misunderstanding of statistics... https://old.reddit.com/r/worldnews/comments/p74lhu/jabbed_adults_infected_with_delta_can_match_virus/h9hvnla/?context=3 (see highlighted comment) | 17:59 |
Brainstorm | Updates for United Kingdom: +48688 cases (now 6.4 million), +865755 tests (now 260.0 million) since 23 hours ago — Greenland: +12 cases (now 285), +460 tests (now 52416) since 22 hours ago | 18:00 |
Brainstorm | New from Contagion Live: Encouraging the COVID-19 and Flu Vaccines: The concept of the “immunization neighborhood” highlighting the importance of pharmacists in encouraging and administering vaccinations. → https://is.gd/S0zLWm | 18:01 |
LjL | someoneelse, de-facto https://twitter.com/EricTopol/status/1428339231764582411 | 18:05 |
someoneelse | yeah i noticed the graph a moment ago, but i had bunch of tweets yet to read, that i opened | 18:06 |
someoneelse | .title https://www.standard.co.uk/news/uk/england-sajid-javid-breakfast-delta-university-of-oxford-b951458.html | 18:06 |
Brainstorm | someoneelse: From www.standard.co.uk: Almost 100,000 deaths estimated to have been prevented in England by Covid jabs | Evening Standard | 18:06 |
someoneelse | that would be with uk intervals | 18:07 |
someoneelse | (which some ppl say woudnt matter, or matter a lot. lets see) | 18:07 |
someoneelse | .title https://www.nature.com/articles/d41586-021-02259-2 | 18:09 |
Brainstorm | someoneelse: From www.nature.com: Delta’s rise is fuelled by rampant spread from people who feel fine | 18:09 |
someoneelse | .title https://twitter.com/EricTopol/status/1428346750738210830/photo/1 | 18:12 |
Brainstorm | someoneelse: From twitter.com: Eric Topol (@EricTopol): "And a graphic summary @FT of some of these reports https://www.ft.com/content/49641651-e10a-45f6-a7cc-8b8c7b7a9710 "Public Health England’s real-world studies in May painted [...] | 18:12 |
someoneelse | .title https://twitter.com/EricTopol/status/1428041047641190400/photo/2 | 18:18 |
Brainstorm | someoneelse: From twitter.com: Eric Topol (@EricTopol): "The Nursing Home resident report https://www.cdc.gov/mmwr/volumes/70/wr/mm7034e3.htm?s_cid=mm7034e3_w" | nitter | 18:18 |
someoneelse | there pfizer would be slightly stronger (overlapping CIs) | 18:19 |
nixonix | .title https://www.nature.com/articles/s41587-021-01037-9 | 18:21 |
Brainstorm | nixonix: From www.nature.com: Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children | Nature Biotechnology | 18:21 |
Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: The early studies predominantly used 8-12 week dosing schedule for Pfizer (cf Israel, US, Qatar 3 weeks), and it was theorized that could explain the preserved effectiveness vs infections. But the new @UniofOxford study says dosing interval did not play a role. Needs replication. → https://is.gd/fnCfN6 | 18:23 |
nixonix | The Oxford scientists showed ... The paper’s authors were not involved in the creation of the AstraZeneca vaccine, which originated at Oxford university. | 18:24 |
nixonix | .title https://www.ft.com/content/49641651-e10a-45f6-a7cc-8b8c7b7a9710 https://archive.is/SdrvW Are vaccines becoming less effective at preventing Covid infection? | 18:24 |
Brainstorm | nixonix: From www.ft.com: Become an FT subscriber to read | Financial Times | 18:24 |
LjL | "Delta’s rise is fuelled by rampant spread from people who feel fine" ← is this different from pre-Delta? it says they test positive 2 days before symptoms, but i thought it was the day or so before symptoms that people were likely most infectious with pre-Delta as well | 18:25 |
nixonix | how long does the (usually causing just meaningless discomfort) side effect last from doses of az? my subjective result was around 17 days after the 2nd dose of pfizer, until i had a day when not even the slightest headache, effect on balance when tired or anything | 18:29 |
nixonix | i supposed it could be longer with az, when viral vectors dna doesnt get destroyed in cells so fast | 18:30 |
de-facto | hmm LjL do you know if those AZ vs BNT comparisons got similar intervals between 1st and 2nd dose? | 18:33 |
LjL | not specifically, but the UK used long intervals for both | 18:34 |
Brainstorm | New from Contagion Live: us: Encouraging Testing for Symptomatic COVID-19 or Flu Patients → https://is.gd/uezQOX | 18:34 |
de-facto | i would assume that influences antibody halflife | 18:34 |
nixonix | High viral loads were maintained between 4 days before onset and 7 days after onset, then decreased gradually to a low but detectable level until about Day 20 | 18:34 |
nixonix | very early i think uk had shorter intervals. at least for mrna | 18:34 |
Brainstorm | Updates for Italy: +7240 cases (now 4.5 million), +55 deaths (now 128634), +206531 tests (now 81.4 million) since 23 hours ago — St. Kitts and Nevis: +34 cases (now 742) since a day ago — Chile: +858 cases (now 1.6 million), +68 deaths (now 36524), +68052 tests (now 19.7 million) since 23 hours ago | 18:37 |
nixonix | dose interval affects cytokine profile, prob th1 or th2 skewed but thats just rough categorization and there could be more into it than just the ratio. so that shorter intervals promote more killer t-cell proliferation, and longer more cd4 types that increase antibodies | 18:37 |
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Delta’s rise is fuelled by rampant spread from people who feel fine ( https://www.zotero.org/groups/covid_links/items/VUQPU4N4 ) | 18:39 | |
nixonix | and its not that simple, becasue cd8 proliferation needs also cd4 | 18:39 |
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: How do vaccinated people spread Delta? What the science says ( https://www.zotero.org/groups/covid_links/items/C86S6V66 ) | 18:44 | |
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children ( https://www.zotero.org/groups/covid_links/items/W8VUCA3E ) | 18:44 | |
nixonix | no information on neut ab titers in that oxford study | 18:45 |
nixonix | so if az would really be longer lasting (not ready to buy it yet), due to circulating neuts or something else? | 18:46 |
LjL | i don't know, a while ago there was a common trope that AZ "probably" elicited more T-cells, although i never quite understood what the basis for saying that was | 18:49 |
nixonix | in uk they gave old people mostly az, and mrna for middle aged, because it was easier to take az to care homes etc, and i think i read that also home living old people werent too willing to go to vax centers (but instead, cant remember how they got vaxed then, but maybe also got az with that alternate way) | 18:51 |
nixonix | so that makes comparison of things like lasting in uk, and also the prevalence of thrombies etc harder | 18:51 |
nixonix | yeah there was some study from april i think that found killer t-cell (i think) response stronger with az | 18:52 |
nixonix | maybe germans and french could find out if az protection lasts longer | 18:53 |
nixonix | and italy, with large population too | 18:54 |
nixonix | in japan cases are now on eu level. and very little testing | 18:54 |
nixonix | unless increased lately | 18:55 |
LjL | nixonix, but we also have a skew of AZ... initially to younger people only, then to older people only... | 18:55 |
nixonix | i dont believe those swedish fatality numbers. they are hiding stuff, howcome you cant find deaths by age group. not testing kids with symptoms etc there | 18:57 |
nixonix | hiding operation started on school transmission in finland too now. they are betting on belief, that kids dont spread it in schools. maybe that was rare with old variant, but i think not anymore | 18:58 |
nixonix | there are powers in hc that dont want kids to be vaccinated. so they want it spread before woudl be their turn | 18:59 |
nixonix | also one hc official in media today said, he believed no 3rd dose needed at least for 2-3 years... | 19:00 |
nixonix | not sure if it was the same dude or another who also claimed theres no evidence this variant would be more severe. theres already lots of evidence, the early data from denmark was the latest | 19:01 |
Brainstorm | Updates for India: +1624 cases (now 32.3 million), +358 deaths (now 432108) since 20 hours ago — Burkina Faso: +12 cases (now 13692) since 21 hours ago — Eritrea: +7 cases (now 6618) since 21 hours ago — Comoros: +5 cases (now 4044) since 2 days ago | 19:02 |
nixonix | great barrington people and semi-antivaxers, they have taken a stand way before, and now they dismiss all the evidence that is contrary to their stand. "we are almost like in north korea", said one of them month ago | 19:03 |
nixonix | are our restrictions, or have they ever been, on level of most of western europe? | 19:04 |
nixonix | new cases have been levelled durign the last week, but too early to say if its real - and schools might change everything. the changes made, a bit more gathering restrictions and bars closed 2 hours earlier in highest prevalence areas (only some of them), now 11 pm | 19:05 |
nixonix | you guys think thats a game changer for us? tell me, we are good now? | 19:06 |
LjL | our curve looks like it's starting to go down, but then if you zoom in it looks much more like it's static now | 19:10 |
LjL | which is still better than going up i suppose | 19:10 |
nixonix | compare day to day with the same days of the last week, without smoothing. then check the trajectory with log scale (and also test numbers and positive share) | 19:11 |
nixonix | one of our hc officials wisdoms: you shoulnt increase restrictions too early or too late. the timing must be right | 19:13 |
nixonix | does that make sense to you? | 19:13 |
LjL | i'm not sure... how can it be "too early"? i mean sure, a bigger wave may come later and then your population is "tired" and restrictions may not be as effective, but how do you know that in advance? | 19:14 |
nixonix | if we hold on to results of the model showing shorter periods of very tight restrictions are more effective than looser but long lasting, would that still make sense to you? | 19:15 |
nixonix | what was the study, i linked it here. it had words "make" and "count" | 19:16 |
nixonix | a bit over year ago i think | 19:17 |
Brainstorm | New from Contagion Live: us: Better Face Masks, Ventilation Mitigates Spread of COVID-19 → https://is.gd/tsSTD8 | 19:17 |
nixonix | another chan probably, though | 19:18 |
LjL | nixonix, i don't know, i'd still consider that you need to start the restrictions as soon as you see R>1 | 19:20 |
LjL | nixonix, no article with "make" and "count" in the URL or title in ##coronalinks on freenode | 19:22 |
LjL | from you | 19:22 |
LjL | assuming you were using this nickname :P | 19:22 |
nixonix | yeah. ill find the study later. but its about how much you let the virus to leak from over the borders. if its very tight, do the restrictions asap when cases increase. if you accept the leak that holds some level of new infections anyway, then when it goes up some threshold that is still very low | 19:22 |
nixonix | that way you can also trace the contacts more efficiently | 19:22 |
nixonix | yeah i did, but when grepping old logs, maybe it didnt include both those words, or they were as a subtitle or something | 19:23 |
LjL | or the bot failed to provided the title | 19:24 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2020.05.19.20107045v1.full | 19:31 |
Brainstorm | nixonix: From www.medrxiv.org: Strict Physical Distancing May Be More Efficient: A Mathematical Argument for Making Lockdowns Count | medRxiv | 19:31 |
nixonix | making. damn it, and it took l-theanine today, after being off for a week! maybe it will really kick in by tomorrow... | 19:32 |
nixonix | oh yeah, i dont find the title in logs, just the link, making it hard to find | 19:35 |
Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: Arguing against the usefulness of boosters negates their impact for preventing infections, helping to block transmission, spread, the potential of #LongCovid, and some % hospitalizations/deaths.That's separate from a global inequity objection. → https://is.gd/VFGIyw | 19:39 |
nixonix | nah, the title was there, but sloppy grepping forgetting -C number from one of the greps... (it was a bot that returned the title, not me) | 19:40 |
nixonix | yeah, some of the hc officials are against vaccinating kids and third doses because they think those doses should be sent elsewhere. but instead of saying it, they usually use other arguments, like "theres no evidence" | 19:42 |
LjL | after about one year, i'm trying again to use a separate Firefox profile for COVID stuff | 19:45 |
LjL | such laziness | 19:45 |
LjL | nixonix, how did you find it? | 19:46 |
Brainstorm | New from WebMD: Delta Whiplash: How the New Surge Is Affecting Mental Health: The new surge in COVID-19 cases related to the contagious Delta variant is affecting the mental health for many people across the country. → https://is.gd/w4w1I7 | 19:50 |
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Strict Physical Distancing May Be More Efficient: A mathematical argument for making the lockdowns count ( https://www.zotero.org/groups/covid_links/items/TQ3UI7TR ) | 19:50 | |
nixonix | some other keywords used, found in logs despite not noticing the missing -C parameter. i tried to google it, but way too many articles on models showed up from just duding the last 8 months or so | 19:53 |
nixonix | but eventually i always find what im looking for | 19:53 |
LjL | good for you, i don't ;( | 19:53 |
nixonix | anyways, there was another model on contact tracing. found through eurekalert i think, around may 2020 | 19:53 |
nixonix | it showd tracing gets stuck with too many cases. the threshold when shit hit the fan was around 300/100k/2weeks i think, in the region | 19:54 |
nixonix | may well be lower with this variant | 19:55 |
nixonix | looking at ozzies now | 19:55 |
nixonix | hardest to find is something you had a glance months earlier in some study, and when remembering would like to read more about it, but no idea what study it was, or what else was in it. remembering just that one particular detail | 19:56 |
nixonix | solution: make notes on what you remember, then give it a bit time to hatch. then adding something else that comes from memory, and eventually you have enough | 19:58 |
nixonix | large url history in browser is handy. too bad i increased the size too late, and i only have urls on this computer (or booted os) starting from late 2020 or so | 20:02 |
nixonix | then similar title problem, you can increase the number of links that it shows from url history to 50 or something (default is 20 i think) | 20:03 |
* twomoon writes notes, then incubates them and hatches something | 20:04 | |
Brainstorm | Updates for Sri Lanka: +3806 cases (now 373165) since 22 hours ago — Albania: +522 cases (now 137597), +2 deaths (now 2473) since 23 hours ago — Qatar: +306 cases (now 230221), +6287 tests (now 2.4 million) since a day ago — Namibia: +197 cases (now 123082), +16 deaths (now 3316), +1731 tests (now 641771) since a day ago | 20:04 |
Brainstorm | New from Eric Topol: @EricTopol: What an outstanding new feature by @kakape on evolution of #SARSCoV2 variants and its potential path forwardhttps://science.sciencemag.org/content/373/6557/844@ScienceMagazine @ScienceVisuals 👍🙏 → https://is.gd/wNHbvt | 20:22 |
Brainstorm | Updates for Spain: +12445 cases (now 4.8 million), +121 deaths (now 83004) since a day ago — Malawi: +35 deaths (now 2047), +1344 tests (now 374045) since 22 hours ago | 20:29 |
nixonix | .title https://www.covid19sim.org/ | 20:39 |
Brainstorm | nixonix: From www.covid19sim.org: Home - COVID-19 Simulator | 20:39 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.08.11.21261845v1.full | 20:43 |
Brainstorm | nixonix: From www.medrxiv.org: Changing Dynamics of COVID-19 in the U.S. with the Emergence of the Delta Variant: Projections of the COVID-19 Simulator | medRxiv | 20:43 |
LjL | HexChat should have *which profile* to open links in as part of its right click menu for links ;( | 20:46 |
nixonix | use two browsers? or another on in vm. not a perfect solution probably. but you can extract urls from places.sqlite. urls with titles, it needs some script | 20:47 |
nixonix | another one | 20:48 |
LjL | nixonix, using two firefox profiles is basically two browsers. it's just that i have to copypaste links from IRC instead of just clicking on them, because clicking sends them to the wrong profile | 20:49 |
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: COVID-19 Simulator ( https://www.zotero.org/groups/covid_links/items/F8MRPG55 ) | 20:50 | |
nixonix | so its either adding the functionality to hexchat or using some kind of autohotkey type solution | 20:54 |
LjL | to be honest i'd rather get rid of HexChat, i've never really liked it. i used to use Konversation when i was using KDE. i would like a modern GTK3 client that's not crap (like Polari) | 20:54 |
Brainstorm | New from CIDRAP: News Scan for Aug 19, 2021: Convalescent plasma for COVID Facebook ads and COVID-19 behavior New clues in Ivory Coast Ebola case H5N6 avian flu case in China → https://is.gd/cKliHE | 20:55 |
LjL | uh, long time since i last saw something COVID-related being actually paywalled on a scientific site. https://science.sciencemag.org/content/373/6557/844 which Topol linked appears to be | 20:57 |
nixonix | btw another day i probably mistakenly supposed ADCC as a mechanism for immune cells to clear free virions, when its more likely ADCP/ADP (they are not well understood for other viruses, or their significance in infection, so prob even less for sars2) | 20:58 |
nixonix | i had to look at some hiv papers to find information on Fc mediated ab effector functions | 20:59 |
nixonix | so whats after sars2? you guys are going to be interested in biosciences when we have got rid of this shit? | 21:01 |
nixonix | i thought i might look at influenza, herpeses, hepatites, hiv. due to their significance and/or retrovirus features | 21:04 |
Brainstorm | Updates for South Africa: +92 deaths (now 78469), +68540 tests (now 15.8 million) since 23 hours ago | 21:07 |
nixonix | i tried to find that science issue, but it wasnt yet at the usual places | 21:07 |
LjL | nixonix, it's not a huge interest of mine. i used to be mildly interested in neurological diseases, mainly how they sometimes show how the brain works including in paradoxical way... but aside from that, i'm mostly just a computer person. | 21:09 |
LjL | but i don't think we'll really have gotten rid of this shit any time soon, so the interest will probably stay for quite a few years... unless at some point i'm saturated, which it does feel like that sometimes | 21:10 |
LjL | i want to provide a platform for people like you who are more into these things and understand them better to have pipelines to communicate with other such people, pipelines with the research, and pipelines with lay people which may be more where i come into play directly, i.e. trying to understand, even if only at a high level, "how things are", and tell other people in a nutshell | 21:12 |
nixonix | funny they have working antivirals (combos tho) for hiv, but nothing really good for sars2 yet. while this should be way easier task. sure its been only 1.5 years, but a lot more resources used | 21:12 |
LjL | it tooks very very long to get antivirals that successfully suppress HIV indefinitely! | 21:14 |
LjL | and other antivirals... think of acyclovir, it's useful, it's an important drug, but it only makes HSV bouts somewhat milder | 21:15 |
LjL | i think antivirals in general haven't been huge successes | 21:16 |
twomoon | antivirals are so cool. you can attack an infection before it's a full blown infection | 21:18 |
twomoon | the idea of that is very cool | 21:18 |
nixonix | .title https://www.cell.com/immunity/fulltext/S1074-7613(21)00347-2 | 21:18 |
Brainstorm | nixonix: From www.cell.com: Live Imaging of SARS-CoV-2 Infection in Mice Reveals that Neutralizing Antibodies Require Fc Function for Optimal Efficacy: Immunity | 21:18 |
twomoon | i guess antivirals are just like enhancing your immune system in terms of headcount | 21:19 |
nixonix | something besides neut abs in circulation, from germinal centers, bone marrow, killer t-cells. significance in humans? not known yet | 21:19 |
LjL | what is "an infection before it's a full blown infection"? antivirals i know of typically disrupt viral replication | 21:20 |
nixonix | they work better the earlier used, during the first few days. less so when hospitalized | 21:21 |
nixonix | so who to use them for, when we dont know who gets it bad and who doesnt (exp those in highest risk but they are mostly vaccinated now) | 21:22 |
nixonix | especially if they are expensive, are iv, require monitoring liver or kidney functions in hospital or something, having side effects | 21:24 |
nixonix | so theres that magic pill project now | 21:24 |
twomoon | ljl : it would be defined by some sort of threshold or headcount of virus-infected cells | 21:25 |
nixonix | while probably some cocktails are needed. lets see if rumors on better antivirals early next year are true | 21:25 |
LjL | nixonix, do you know about ##virology? not much talk (almost none) but a *lot* of papers, not all about COVID but a lot about COVID, get posted automatically | 21:26 |
nixonix | where could those rumors originate from, when they need trials that will take time. maybe from some pharmas | 21:26 |
nixonix | is it still itchys channel? i havent visited there since last summer, sometimes to chat with itchy | 21:27 |
LjL | i don't know. which antivirals work even to a modest extent *now*? like, which ones work non-controversially, so not hydrochlorowhatevers? | 21:27 |
Brainstorm | New from Eric Topol: @EricTopol: I'm in clinic today and so impressed that every patient is coming in wearing N95 or KN95 masks 😷👍 → https://is.gd/fKOyNv | 21:27 |
LjL | dTal, ↑ apparently not your clinic | 21:27 |
nixonix | there are new monoclonal antibodies that seem to be somewhat effective, and some of them cross-neutralising several variants | 21:29 |
twomoon | ljl did they go zotero in ##virology? | 21:29 |
nixonix | and some older ones made obsolete by this variant | 21:29 |
LjL | twomoon, no, it's a bot posting things from, i presume, various RSS sources. more than here, and here it's mostly not directly studies, but things that talk about studies | 21:31 |
nixonix | .title https://www.cell.com/immunity/fulltext/S1074-7613(21)00345-9 | 21:31 |
Brainstorm | nixonix: From www.cell.com: A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants: Immunity | 21:31 |
dTal | LjL: to be fair the compliance is very high - but there's always one, isn't there | 21:32 |
LjL | dTal, but it's a failure when there's nobody saying "sorry sir, you cannot enter without a mask" | 21:33 |
LjL | dTal, and here afaik you really cannot, if anything they give you a surgical | 21:34 |
nixonix | claimed in some tweet, in a discussion on pfizer vs az results: "(Though note in the UK many of the <9 weeks were 6-9, not just 3-4 weeks.)" | 21:51 |
nixonix | "There was no evidence that effectiveness varied by dosing interval, but protection was higher among those vaccinated following a prior infection and younger adults" "In addition, in this Delta-dominant period, we investigated variation in vaccine effectiveness by long-term health conditions, age (18-34 versus 35-65 years) interval between first | 21:56 |
nixonix | and second vaccination (<9 weeks versus ≥9 weeks), and prior infection | 21:56 |
nixonix | Importantly, there was no evidence that effectiveness depended on the interval between first and second vaccinations (<9 weeks versus ≥9 weeks). | 21:56 |
nixonix | from that paper. theres a table in the end, but its only <9 weeks and >=9 | 21:57 |
nixonix | when something like 6-8 weeks might be almost as good as 12, ab titer wise. so they really have no information if 3-4 weeks is good or not | 21:58 |
nixonix | its all mixed up with those 6-9 weeks, if the claim above is true | 21:59 |
nixonix | sloppy shit | 21:59 |
nixonix | then again, if they only used short interval very early on, they couldnt find out about difference between 3-4 weeks and 12 weeks. and probably werent even interested, other than if their new 8 week interval is good or not | 22:08 |
nixonix | .title https://twitter.com/AlisonNolan9/status/1428279074133323783 | 22:17 |
Brainstorm | nixonix: From twitter.com: Alison Nolan (@AlisonNolan9): "Very few people in the UK had Pfizer on a three week schedule. We started vaccinating on the 8th of December and switched to the 12 week gap around new year so only the [...] | 22:17 |
Brainstorm | New from CIDRAP: Early US vaccine efforts may have prevented 140K COVID deaths, 3 million cases: Mary Van Beusekom | News Writer | CIDRAP News Aug 19, 2021 Vaccines also saved an estimated $625 billion to $1.4 trillion by early May. → https://is.gd/hybCGt | 22:21 |
nixonix | .title https://www.nejm.org/doi/full/10.1056/NEJMoa2108453 | 22:23 |
Brainstorm | nixonix: From www.nejm.org: Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors | NEJM | 22:23 |
nixonix | sars-1 ! | 22:24 |
Brainstorm | New from CIDRAP: Biden calls for schools to be allowed COVID mask mandates: Lianna Matt McLernon | News Writer | CIDRAP News Aug 19, 2021 As the school year begins, COVID hospitalizations are rising for children. → https://is.gd/ezt67j | 22:31 |
Brainstorm | Updates for North Macedonia: +1155 cases (now 165684), +19 deaths (now 5608) since a day ago — Turkey: +25978 cases (now 6.2 million), +216 deaths (now 53891), +292538 tests (now 73.0 million) since 20 hours ago — France: +15618 cases (now 6.6 million), +88 deaths (now 113137) since 19 hours ago — Canada: +2389 cases (now 1.5 million) since 22 hours ago | 22:34 |
dTal | so is it possible, nay likely, that people with long covid are in fact still infected | 22:37 |
dTal | in some deep interior reservoir, like bone marrow | 22:37 |
dTal | I'm putting together a picture here | 22:38 |
dTal | it seems that a) SARS-CoV-2 spike protein elevates clotting factors and, b) people with long covid have elevated clotting factors but no inflammation | 22:41 |
LjL | dTal, i think so, i have a goto study for that, although it may just be one of the possible random shot at where the virus can be | 22:42 |
dTal | and c) vaccination often relieves symptoms of long covid | 22:42 |
Brainstorm | New from Eric Topol: @EricTopol: Today 44% more Floridians are in the hospital than any time during the pandemic.Fulfilling informal definition of "train wreck": a chaotic or disastrous situation → https://is.gd/VP5zu0 | 22:42 |
dTal | also this incidentally says some unhappy things about mRNA vaccines and blood clots | 22:43 |
LjL | dTal, https://www.nature.com/articles/s41586-021-03207-w | 22:43 |
LjL | dTal, also fwiw, TurboTech said yesterday in his experience, patients who come back to the hospital 30 days (possibly more than 30 days too, but we were talking about 30 days due to his own COVID) after testing positive *still* test positive. he puts it down to "debris" i suppose. | 22:44 |
nixonix | .title https://www.news-medical.net/news/20210819/Durable-highly-protective-T-cell-response-to-AAV-spike-vaccine-against-COVID-19-pneumonia-in-mice.aspx | 22:45 |
Brainstorm | nixonix: From www.news-medical.net: Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice | 22:45 |
LjL | they made their own animal vaccine? | 22:46 |
nixonix | no, they knocked off neut ab side of the vaccine, leaving cellular protection. upon exposing they developed strong and lasting ab protection anyway | 22:47 |
nixonix | i only read the article yet, but that was very interesting | 22:47 |
nixonix | both immediate and durable T cell protection against infection with this virus, despite a remarkable absence of neutralizing antibodies, was demonstrated in mice. Thirdly, unexpected, this cellular response accelerated the affinity maturation of neutralizing antibodies to the mutant RBD irrespective of the SARS-CoV-2 variant to which the host is | 22:48 |
nixonix | initially exposed. | 22:48 |
nixonix | This could bypass antigenic imprinting to the RBD epitopes of the Wuhan lineage caused by first-generation vaccines. T cell epitopes cover a range of epitopes on the spike protein sequence, unlike B cells which focus on a narrow range of conformational epitopes that are targeted by most individuals for successful neutralization | 22:49 |
nixonix | ag imprinting is original antigenic sin | 22:50 |
nixonix | but wait, theres more, close to the same subject than couple of articles above: | 22:52 |
nixonix | .title https://www.news-medical.net/news/20210819/SARS-CoV-2-antibodies-found-to-neutralize-bat-coronavirus-(RaTG13)-in-new-study.aspx | 22:52 |
Brainstorm | nixonix: From www.news-medical.net: SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study | 22:52 |
Brainstorm | New from r/WorldNews: worldnews: Fears of 'violent' delta offshoot arise in Israel with 10 new cases of AY.3 reported → https://is.gd/xu74tJ | 22:52 |
nixonix | meaning cross-glade vaccine, or universal betacoronavirus vaccines | 22:53 |
nixonix | or clade | 22:54 |
LjL | uhm, the "violent offshot" above | 22:59 |
LjL | they're worrying for 10 cases in Israel, but it says in the US the same variant already accounts for 15% of cases | 23:00 |
LjL | so can vaccine efficacy be even *worse* elsewhere than what Israel reported? | 23:00 |
nixonix | what variant? | 23:01 |
nixonix | .title https://www.sciencedaily.com/releases/2021/08/210816125717.htm | 23:04 |
Brainstorm | nixonix: From www.sciencedaily.com: Blood clotting may be the root cause of Long COVID syndrome, research shows -- ScienceDaily | 23:04 |
nixonix | spikes from vaccine and clotting? source for that? | 23:04 |
nixonix | (but there seems to be lots of different roots for long covid, permanent organ damage, and stuff) | 23:07 |
nixonix | spikes from vaccine causing clotting - i meant relating to mrna vaccines. vector vaccines, at least az, thats another thing | 23:09 |
Brainstorm | Updates for India: +2043 cases (now 32.3 million), +298 deaths (now 432113) since 20 hours ago | 23:11 |
LjL | some sub-variant of Delta, AY.3 they call it | 23:13 |
nixonix | Our results show that the B.1.617.1 variant was 6.8 times less susceptible, and the B.1.617.2 variant was 2.9 times less susceptible, to neutralization by serum | 23:13 |
nixonix | nothing to see here? "There are no known significant properties of this mutation | 23:19 |
nixonix | but: people who had received Covaxin developed 23% lower levels of antibodies against delta variant infections (compared to infections of the B.1 strain); 33% lower against AY.1 and nearly 47% lower against AY.3 | 23:20 |
nixonix | so no key mutation, but somehow it has better immune evasion | 23:20 |
nixonix | mutations | 23:21 |
twomoon | at what point do they call it epsilon and not 'delta offshoot' | 23:21 |
dTal | it's not different enough supposedly | 23:21 |
dTal | the technical term is "Delta Variant AY.3 Sublineage" | 23:21 |
dTal | ah LjL beat me to it | 23:22 |
nixonix | In the Pangolin nomenclature, AY.2 is also called B.1.617.2.2 | 23:28 |
nixonix | AY.3 is also known as B.1.617.3 | 23:28 |
nixonix | sakes mense | 23:28 |
nixonix | i only found one difference in orf1a, compared to 617.2 | 23:35 |
nixonix | so its prob just founder effect | 23:36 |
Brainstorm | Updates for Guatemala: +5826 cases (now 428096), +66 deaths (now 11339) since a day ago — Mali: +21 cases (now 14735) since a day ago | 23:36 |
nixonix | neutralization differencies, maybe it exists, or then it doesnt... | 23:36 |
nixonix | https://outbreak.info/compare-lineages?pango=AY.3&pango=B.1.617.2&gene=ORF1a&gene=ORF1b&gene=S&threshold=75&dark=true | 23:37 |
nixonix | i dont know about you, but we already have operation final spurt here | 23:44 |
nixonix | and have had it since february | 23:44 |
nixonix | no joke, told by a minister in feb | 23:45 |
nixonix | hope its shorter operation than afghanistan (where i just read finland is sending more troops for some reason) | 23:48 |
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