| Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: This doesn't look goodhttps://www.wsbtv.com/news/local/metro-atlanta-school-districts-report-nearly-7000-cases-covid-19-first-weeks/KO37EA3M5NDRFPGCGVEY6OIA4U/ → https://is.gd/kwp5Bw | 00:30 |
|---|---|---|
| LjL | Spec_, ↑ | 00:31 |
| supervax | what does IgE signal peptide do in a vaccine? | 00:33 |
| supervax | google helped: “IgE signal peptide” results in better antibody production rates | 00:34 |
| supervax | indian new dna plasmid vaccine has that. needs 3 doses! | 00:34 |
| LjL | i don't even try to understand the immune system ;( | 00:34 |
| LjL | supervax, which is that? a newly approved vaccine? | 00:35 |
| supervax | which would be a mess with optimizing dosing, stuff like ab maturation and what not. but if its good, i guess why not | 00:35 |
| supervax | .title https://www.bbc.com/news/world-asia-india-57774294 | 00:35 |
| Brainstorm | supervax: From www.bbc.com: India approves world's first DNA Covid vaccine - BBC News | 00:35 |
| LjL | %vax zycov | 00:36 |
| Brainstorm | LjL, DNA plasmid is a DNA-based vaccine developed in India by Zydus Cadila, which started testing on humans initially on Jul 13, currently employing 1048 healthy volunteers aged 18-55 → https://covidvax.org/covid19-vaccine/ZydusCadilaDNA | 00:36 |
| LjL | why haven't we been RSS'd about it | 00:37 |
| LjL | my selection is SUBOPTIMAL | 00:37 |
| supervax | those chinese vaccine names, lemme quote from wiki | 00:37 |
| supervax | china has two big vaccines on market, one made by sinopharm, one by sinovac. both whole virus inactivated type (abs declining fast according to thais, so whole virus wouldnt look like a solution) | 00:38 |
| supervax | BBIBP-CorV, also known as the Sinopharm COVID-19 vaccine[1] or BIBP vaccine,[1][2][3] is one of two inactivated virus COVID-19 vaccines developed by Sinopharm's Beijing Institute of Biological Products (sometimes written as Beijing Bio-Institute of Biological Products,[4] resulting in the two different acronyms BBIBP and BIBP for the same vaccine) | 00:39 |
| supervax | and sinopharm seems to have two whole virus sars2 vaccines | 00:39 |
| supervax | BBIBP-CorV shares similar technology with CoronaVac and Covaxin, other inactivated virus vaccines for COVID-19.[6] Its product name is SARS-CoV-2 Vaccine (Vero Cell),[7][8][9] not to be confused with the similar product name of CoronaVac | 00:39 |
| LjL | this looks more updated than covidvax https://covid19.trackvaccines.org/vaccines/29/ | 00:40 |
| supervax | when looking at another sino... vax wiki page, it doesnt mention it also uses or has used name "vero cell", but it has several links that mention that name too | 00:40 |
| supervax | and yet another name for it is picovacc | 00:40 |
| LjL | yes, quite confusing | 00:41 |
| supervax | and vero chell is also a common cell line, as ppl on this channel likely know (green african monkeys, was it, kidney cells) | 00:41 |
| supervax | cell | 00:41 |
| supervax | so when i read they used "vero cell" vaccine in vietnam, i thought i knew which one. but apparently not | 00:42 |
| LjL | maybe i should do something like %variants for vaccine names too | 00:42 |
| LjL | but it might be overwhelming to maintain manually ;( | 00:43 |
| LjL | also the %vax command is already taken! | 00:43 |
| nixonix | .title https://www.bangkokpost.com/thailand/general/2147667/sinovac-produced-antibodies-halve-every-40-days | 00:43 |
| Brainstorm | nixonix: From www.bangkokpost.com: Sinovac-produced antibodies 'halve every 40 days' | 00:43 |
| nixonix | They found that, on average, people began having symptoms 5.8 days after infection with Delta — 1.8 days after they first tested positive for viral RNA. That left almost two days for individuals to shed viral RNA before they showed any sign of COVID-19. | 00:50 |
| nixonix | An earlier study2 and an unpublished analysis by Cowling and others estimate that before Delta emerged, individuals infected with SARS-CoV-2 took an average of 6.3 days to develop symptoms and 5.5 days to test positive for viral RNA, leaving a narrower window of 0.8 days for oblivious viral shedding. | 00:51 |
| nixonix | .title https://www.nature.com/articles/d41586-021-02259-2 | 00:51 |
| Brainstorm | nixonix: From www.nature.com: Delta’s rise is fuelled by rampant spread from people who feel fine | 00:51 |
| Brainstorm | New from WebMD: The Best Face Masks for Kids, According to Experts: Finding a face mask that's actually protective for a child is not a straightforward task, as many parents can attest. → https://is.gd/weoZJy | 00:51 |
| LjL | %papers zycov | 00:51 |
| Brainstorm | LjL, 4 results out of 4: Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models by Ayan Dey et al, dated 2021-06-15 → https://www.doi.org/10.1016/j.vaccine.2021.05.098 [... want %more?] | 00:51 |
| nixonix | .title https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00300-X/fulltext | 00:52 |
| Brainstorm | nixonix: From www.thelancet.com: Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India - [...] | 00:52 |
| LjL | %more | 00:53 |
| Brainstorm | LjL, [...] increasedhttps://www.oregon.gov/oha/covid19/Documents/DataReports/Breakthrough-Case-Report-08-19-2021.pdf → https://paste.ee/p/5FvIb | 00:53 |
| Brainstorm | LjL, [...] Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India by Taufik Momin et al, dated 2021-07-27 → https://www.doi.org/10.1016/j.eclinm.2021.101020 [...] → https://paste.ee/p/MEa2j | 00:53 |
| LjL | nixonix, thanks | 00:53 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India ( https://www.zotero.org/groups/covid_links/items/2F9GIIVR ) | 00:56 | |
| nixonix | here's prob the best short description | 00:59 |
| nixonix | .title https://www.news-medical.net/news/20210202/ZyCoV-D-DNA-vaccine-immunogenic-against-SARS-CoV-2-in-animal-models.aspx | 00:59 |
| Brainstorm | nixonix: From www.news-medical.net: ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models | 00:59 |
| nixonix | the platform is used in couple vaccines before. some kind of device they dont call electroporation, but maybe similar | 00:59 |
| nixonix | .title https://twitter.com/EricTopol/status/1428788215389908993 check the next post too (and article links) | 01:04 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "New reports on interferon (IFN) and Covid-19 1. IFN Auto-antibodies in ~14% of patients w/ critical Covid, and are present pre-Covid, increasing with age (>6% for over age [...] | 01:04 |
| nixonix | so when some finnish expert said, something seems to happen to immune response in the age of 60, for ifn autoantibodies that would be more like 70 | 01:05 |
| LjL | antibodies against interferon? that people develop because they're old? | 01:06 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: ZyCoV-D DNA vaccine immunogenic against SARS-CoV-2 in animal models ( https://www.zotero.org/groups/covid_links/items/8QJH6IMT ) | 01:06 | |
| nixonix | type 1 interferons | 01:06 |
| LjL | <CarlSagan> [Ars Technica - Science] Report: Pfizer’s COVID-19 vaccine may get full FDA approval Monday https://arstechnica.com/?p=1788948 2021-08-20T22:38:28 | 01:06 |
| nixonix | sars 2 has immune evasion mechanisms, like suppressing ifn-I, that dont activate right in the beginning, but after some delay. and it was enhanced - was it in kent or indian variant, dont remember for sure right now, gotta check | 01:08 |
| nixonix | due to mutation in either variant | 01:08 |
| nixonix | they have tried interferons as prophylaxis or very early symptoms. i think it was first tried with inf-alpha, and while they claimed in china nobody got infected, probably in the west results werent good | 01:10 |
| nixonix | then later inf-beta. and my memory might serve wrong the order and this: inf-beta was supposed to have more side effects than alpha (or vice versa), but then later tested anyway | 01:11 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: Thoughts on COVID booster shots. → https://is.gd/ltnkrs | 01:13 |
| nixonix | there was some research last fall already, that around 10% had autoantibodies for inf-I, and that might explain poor results in convalescent plasma studies, and they should screen them first to find who had those | 01:13 |
| nixonix | .title https://www.nationalgeographic.com/science/article/evidence-mounts-that-people-with-breakthrough-infections-can-spread-delta-easily | 01:17 |
| Brainstorm | nixonix: From www.nationalgeographic.com: Evidence mounts that people with breakthrough infections can spread Delta easily | 01:17 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.07.31.21261387v3 | 01:17 |
| Brainstorm | nixonix: From www.medrxiv.org: Shedding of Infectious SARS-CoV-2 Despite Vaccination when the Delta Variant is Prevalent - Wisconsin, July 2021 | medRxiv | 01:17 |
| nixonix | .title https://www.nytimes.com/2021/08/20/business/economy/china-vaccine-us-covid-diplomacy.html | 01:19 |
| Brainstorm | nixonix: From www.nytimes.com: China’s Vaccine Diplomacy Stumbles in Southeast Asia - The New York Times | 01:19 |
| nixonix | SARS-CoV-2 is characterized by extensive intracellular replication and a remarkable absence of IFN production and secretion. On the other hand, SARS-CoV-2 is highly sensitive to treatment with IFNs before or after infection, as shown in lung epithelial cells, even more so than SARS-CoV | 01:22 |
| nixonix | from that innate immuny paper | 01:22 |
| Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: It was overdue back then. Afterwards, they got "all hands on deck" which surely helped. For the life of me, I'll never understand, why, for the #1 public health issue, this didn't happen much sooner.https://www.nytimes.com/2021/07/01/opinion/fda-vaccines-full-approval.html @nytopinion → https://is.gd/yvztYa | 01:23 |
| nixonix | has jnj applied for full approval? | 01:24 |
| nixonix | also when there are fully approved vaccines, new vaccines cant get eua (according to some source, if true). so its a lengthier process for new vaccines | 01:25 |
| nixonix | you try those innate immune response vacclines a la van bossche, youll end up with weak neutralization (because no immune memory for antibodies) and VAERD | 01:31 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: R to @profshanecrotty: The original coronavirus wasn't that hard for the immune system to stop, and 2-doses of vaccine worked amazing --even 1-dose was good. Most vaccines are a 3 dose regimen. → https://is.gd/4kV1kt | 01:34 |
| nixonix | you guys read those articles on P681R that topol tweeted? it seems its not just that mutation increasing cell infectivity (furin cleavage and cell fusion), because it hasnt had similar effect on other variants that had it too | 01:36 |
| nixonix | but when it was removed, infectivity reduced a lot. so its a mystery, some other spike mutations affecting, or something else like in N protein or accessory proteins | 01:39 |
| nixonix | solve that, and youll be famous | 01:39 |
| nixonix | Whittaker doesn't expect P681R to be the last furin cleavage site mutation to cause concern. “I’m waiting to see what happens next.” | 01:40 |
| nixonix | .title https://www.nature.com/articles/s41591-021-01421-7 | 01:42 |
| Brainstorm | nixonix: From www.nature.com: Has SARS-CoV-2 reached peak fitness? | Nature Medicine | 01:42 |
| nixonix | and kent variant has immune evasion mechanisms and some other tricks that 617.2 doesnt yet have. could they be in the same variant at the same time? probably most of them | 01:44 |
| Brainstorm | New from BBC Health: Covid: CO2 monitors pledged to aid school ventilation: Schools in England are to be given CO2 monitors to as part of plans to limit the spread of Covid. → https://is.gd/hMzNbb | 01:45 |
| nixonix | not here, we are flying blind geneva style. thats just how we roll | 01:46 |
| nixonix | in finnish they are geneve and genova | 01:47 |
| nixonix | so it wasnt the first time i confuse them. kind a like kolumbus, columbus, colombo, colon, colombia, british columbia. lots of interference | 01:49 |
| Brainstorm | Updates for Tunisia: +3127 cases (now 635455), +90 deaths (now 22394), +12600 tests (now 2.4 million) since a day ago — Guatemala: +5243 cases (now 433339), +33 deaths (now 11372), +15606 tests (now 2.1 million) since a day ago — Niger: +11 cases (now 5761) since a day ago — Guyana: +44 cases (now 23839), +2524 tests (now 251230) since a day ago | 02:01 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: R to @profshanecrotty: For context: I care a lot about global equity issues. I spent most of my waking hours in the pre-COVID decade working on an HIV vaccine. (And I still do!) → https://is.gd/7PxQmQ | 02:16 |
| nixonix | .title https://www.brusselstimes.com/belgium/181660/doctors-advise-against-intensive-sport-after-covid-vaccination/ | 02:17 |
| Brainstorm | nixonix: From www.brusselstimes.com: Doctors advise against intensive sport after Covid vaccination | 02:17 |
| nixonix | new guidance in finnish army, no heavy exercises in a few days after vaccinations | 02:18 |
| nixonix | but not even once was that guidance given to general population... | 02:19 |
| LjL | :\ | 02:22 |
| LjL | except by de-facto | 02:22 |
| LjL | “It is impossible to demonstrate a direct link between the vaccine and these heart problems. That is in progress,” | 02:23 |
| LjL | maybe it isn't possible, but maybe it's possible to *predict* it based on the fact we know about the myocarditis side effect and what happens to people who have myocarditis if they do sports without knowing | 02:23 |
| LjL | just maybe | 02:23 |
| nixonix | you mean here? i think when i told you in juone about avoiding exercise you said you rode exercise bike rigth afterwards | 02:32 |
| LjL | no, i mean in general | 02:32 |
| LjL | i definitely didn't ride an exercise bike although i might have treadmilled | 02:32 |
| nixonix | in article now finnish vaccine and hc chief said, its bee speculated its caused by inflammatory response in young men, that is strong | 02:32 |
| LjL | also it says it tends to happen in more athletic young people so i'm probably safe | 02:33 |
| nixonix | ok treadmill maybe, i dont have logs (: | 02:33 |
| LjL | i basically walked, nixonix | 02:33 |
| LjL | i made a risk/benefit assessment and figured the risk was pretty close to zero | 02:33 |
| LjL | i did not dismiss the concern in an overarching sense | 02:33 |
| nixonix | pretty sure you said you used some device | 02:34 |
| LjL | yes a treadmill can be used for walking on :P | 02:34 |
| LjL | in fact i can barely use it for running | 02:34 |
| nixonix | like those in hamster cages, but bigger? | 02:34 |
| LjL | ... no | 02:34 |
| LjL | that would be fun but my apartment isn't so big | 02:35 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Guidance on Additional COVID-19 Vaccine Dose for MS Patients → https://is.gd/9uGzZ0 | 02:37 |
| nixonix | there was some reports of lots of myocardites among athletes when rona infection, but i think they were then disproved (the risk is there, but its not super common, more so than after vaccines tho) | 02:37 |
| Brainstorm | Updates for Ukraine: +1488 cases (now 2.3 million), +32 deaths (now 54878) since 21 hours ago — Angola: +258 cases (now 45583), +5 deaths (now 1138) since 22 hours ago — France: +25509 cases (now 6.6 million), +63 deaths (now 113280) since 21 hours ago — Antigua and Barb.: +26 cases (now 1447) since 2 days ago | 02:38 |
| nixonix | but why havent they found the same signal from az or jnj | 02:40 |
| nixonix | maybe those nanoparticles affect the immune response, which i think is the reason anyway. and not the spikes, but the local immune response that causes it may still be caused by vaccine getting in blood vessels | 02:42 |
| LjL | maybe they've just focused a lot more on the blood clotting issues with AZ/J&J= | 02:43 |
| nixonix | i really would like to know the truth on adverse effects from sputnik and those chinese vaccines. especially those chinese, whole virus | 02:44 |
| LjL | also, how come there are no "waves" here but it's basically a continuous growth http://offloop.net/covid19/?default=Guatemala&cumulative=no&smooth=yes while in Europe and the US and other places we see clear waves comming and waning | 02:44 |
| LjL | too bad that Chinese guy didn't show up again | 02:45 |
| nixonix | why have russia had almost constant bit under 800 deaths per day for the last 5 weeks | 02:47 |
| nixonix | ok, one day was 800, another one 799. but mostly 780-799 | 02:48 |
| nixonix | the chinese last summer, or somebody else? | 02:50 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Bears, baboons, tigers are getting COVID vaccines at zoos across the U.S. → https://is.gd/QXPI45 | 02:58 |
| nixonix | Our results suggest that, even for this high-risk subgroup, the risk of myocarditis from COVID-19 infection is about 5.9 times as great, at a rate of 450 cases per million. | 03:03 |
| Brainstorm | Updates for French Guiana: +191 cases (now 33060), +1896 tests (now 347345) since a day ago | 03:03 |
| nixonix | and from mrna vaccine its mild 95% of times, and afaik nobody has died (which would be almost unbelievable, but apparently its very rare at least) | 03:04 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.07.23.21260998v1.full | 03:05 |
| Brainstorm | nixonix: From www.medrxiv.org: Risk of Myocarditis from COVID-19 Infection in People Under Age 20: A Population-Based Analysis | medRxiv | 03:05 |
| Brainstorm | Updates for Dominican Rep.: +373 cases (now 347370) since a day ago — Egypt: +164 cases (now 285995), +7 deaths (now 16654) since 23 hours ago — Curacao: +87 cases (now 14889), +2025 tests (now 220413) since a day ago — Channel Islands: +51 cases (now 10204), +14365 tests (now 785170) since 22 hours ago | 03:40 |
| Jbwncster | https://i.imgur.com/FabH5N0.jpg | 03:48 |
| Brainstorm | New from Eric Topol: @EricTopol: A multicenter randomized trial of awake prone positioning versus standard care for Covid respiratory failure shows significant reduction for the need of intubation and the incidence of treatment failurehttps://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00356-8/fulltext @LancetRespirMed → https://is.gd/c2cK4C | 03:51 |
| pwr22 | Apologies if this is already posted somewhere in here: https://www.nature.com/articles/d41586-021-02275-2 | 04:02 |
| pwr22 | Quite interesting, I wonder if this means that a vaccine targeting the delta spike could attenuate it's advantage? | 04:02 |
| Brainstorm | Updates for Trinidad and Tobago: +257 cases (now 42839), +7 deaths (now 1215) since a day ago — Eq. Guinea: +39 cases (now 9049) since 2 days ago | 04:30 |
| pwr22 | LjL: It seems like matrix has changed the reply format now (at least that's what it sounds like) | 04:30 |
| LjL | pwr22, yes, it has, for some time now, one tiny bit of good news | 04:31 |
| pwr22 | What does it do now? | 04:31 |
| pwr22 | <LjL> "maybe they've just focused a lot..." <- Apologies, testing 😛 | 04:32 |
| pwr22 | pwr22: But this one should not quote I think | 04:33 |
| pwr22 | Yay | 04:33 |
| Brainstorm | New from Eric Topol: @EricTopol: Free, effective, but little talk on monoclonal antibodieshttps://www.washingtonpost.com/health/covid-monoclonal-abbott/2021/08/19/a39a0b5e-0029-11ec-a664-4f6de3e17ff0_story.html by @LennyMBernstein and @lauriemcginley2 w/ @DrNunezSmith46 @JGPharmD → https://is.gd/AoZ6nk | 04:34 |
| pwr22 | LjL: the bridge team has a new hire, tadzik, who is to thank for these things I think | 04:35 |
| LjL | i wonder who that guest was | 04:35 |
| * pwr22 is unsure if sarcasm | 04:35 | |
| LjL | pwr22, well it's good to know *someone* can fix a reply format that everyone hated :P | 04:35 |
| pwr22 | 😀 it was me just in case | 04:35 |
| LjL | i wouldn't say sarcasm, just playfulness | 04:35 |
| pwr22 | Ah ok | 04:35 |
| pwr22 | LjL: someone fixed it ages ago but the bikeshedding started by the original opener of the issue killed the PR | 04:36 |
| pwr22 | So it is actually an IRC user who opened the issue who caused it to remain a bad implementation | 04:36 |
| pwr22 | because they wanted a perfect solution which also a lot of other stakeholders did not like | 04:37 |
| pwr22 | Perfect is enemy of good 😀 | 04:37 |
| LjL | meh i'm not sure i can blame whoever opened the issue, they *should* be able to tell what's appropriate to implement and what can be ignored | 04:38 |
| LjL | anyway glad we've got something slightly less ugly than before finally | 04:38 |
| pwr22 | Sure, I just mean they kicked off the bikeshedding | 04:38 |
| pwr22 | From how the issue looks, if they had said "yeah that's great" then it would have been "fixed" years ago | 04:38 |
| LjL | sigh | 04:39 |
| LjL | well, the current format is very close to how *i* quote people on irc | 04:39 |
| LjL | except with <- instead of ← but maybe that's for the best :P | 04:39 |
| pwr22 | Lol, on the matrix side those are the same | 04:39 |
| LjL | oh | 04:39 |
| pwr22 | Although the first is two characters | 04:40 |
| pwr22 | So looks like they have ligatures on in element I guess | 04:40 |
| LjL | i'll have a look in about 10 minutes after Element loads | 04:40 |
| pwr22 | 😀 | 04:40 |
| pwr22 | You mean you don't have 24 cores dedicated to it 😲 | 04:40 |
| LjL-Matrix | This is a laplet, I don't even have a fan cooling the processor | 04:41 |
| LjL-Matrix | and it's running on batteries which means tlp tunes the processor speed down :P | 04:42 |
| pwr22 | Oh, it's passively cooled? | 04:42 |
| LjL-Matrix | anyway yeah I see even if I type it, the moment I add - to < it turns into ← | 04:42 |
| LjL-Matrix | Yes, it's basically a tablet with a detachable keyboard/touchpad, although that description is a bit unfair to its capabilities | 04:42 |
| pwr22 | Yeah, just like my ligatures in vscode | 04:42 |
| pwr22 | TIL the term laplet 😀 | 04:43 |
| LjL-Matrix | It's getting on the slow side these days, but still, it has 8GB of RAM, a nice 1080p screen on 12", and the keyboard attachment contains an additional battery. It's old now and doesn't last very long anymore but it did about 10 hours on Linux originally (more on Windows) | 04:43 |
| pwr22 | Ah | 04:43 |
| pwr22 | Sounds cool yeah - pun intended | 04:43 |
| pwr22 | 😛 | 04:43 |
| LjL-Matrix | They call them "convertibles" and other things like "2-in-1" but "laplet" was an early term that I stuck with as I like it best :P | 04:43 |
| LjL-Matrix | It's running at 42°C right now say the sensors | 04:44 |
| LjL-Matrix | and it isn't hot at all to the touch, sometimes it is hot, but who cares since it's the screen - although Spec_ would care because he needs hot keyboards to type on :P | 04:44 |
| LjL-Matrix | One problem with it, the weight is very finely balanced, the keyboard has just enough weight to offset the screen which contains all the computery bits, and so now that it's no longer so new and the hinge has loosened a little, it's very easy for it to just tip over | 04:45 |
| LjL-Matrix | It's not a bad machine but definitely doesn't last as long as a Thinkpad :P | 04:45 |
| LjL-Matrix | In fact let me get the T5 screwdriver and tighten the keyboard screw that always comes lose and causes much of the tipping over :P | 04:46 |
| LjL-Matrix | I bought this in 2017 | 04:46 |
| LjL-Matrix | I had been hoping I could just buy a replacement keyboard for this once the keyboard's battery (and hinge) wore out, but I think they sold so few of these, they never really show up on eBay | 04:48 |
| LjL-Matrix | Also Brexit is a bummer, buying anything used with a sane keyboard layout just got a lot more difficult ;( | 04:48 |
| Brainstorm | Updates for Brunei: +197 cases (now 1333) since 16 hours ago | 05:32 |
| Brainstorm | New from Shane Crotty: @profshanecrotty: Very well said @Bob_Wachter. Admirable clarity on a very challenging vaccine issue → https://is.gd/cQikqq | 06:09 |
| Brainstorm | New from This Week In Virology: TWiV 795: COVID-19 clinical update #76 with Dr. Daniel Griffin: In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a [... want %more?] → https://is.gd/TsnDH4 | 06:19 |
| twomoon | hola como estan | 06:32 |
| Brainstorm | Updates for Honduras: +1600 cases (now 326830), +50 deaths (now 8594), +4040 tests (now 945963) since 22 hours ago | 06:34 |
| Brainstorm | New from The Indian Express: World: Pfizer’s two-dose vaccine nears full approval by FDA → https://is.gd/Ij7X7x | 06:41 |
| pwr22 | <LjL-Matrix> "Also Brexit is a bummer, buying..." <- Are European keyboard layouts insane 😂? | 06:44 |
| Brainstorm | Updates for California, United States: +25908 cases (now 4.2 million), +101 deaths (now 65021) since 23 hours ago — Kansas, United States: +5495 cases (now 357004), +98 deaths (now 5498) since 23 hours ago — Michigan, United States: +4846 cases (now 1.0 million), +40 deaths (now 21393) since a day ago [... want %more?] | 07:36 |
| Brainstorm | Updates for India: +34457 cases (now 32.4 million) since 22 hours ago | 09:03 |
| Brainstorm | New from The Indian Express: World: Major US companies making masks, vaccines mandatory → https://is.gd/pt7tIK | 09:09 |
| Brainstorm | New from r/WorldNews: worldnews: Toronto hospital network says they will fire unvaccinated employees → https://is.gd/AnSzeI | 09:30 |
| Brainstorm | Updates for Georgia: +53 cases (now 506093), +5 deaths (now 6654), +46595 tests (now 7.7 million) since 22 hours ago — New Caledonia: +1 cases (now 135), +1102 tests (now 41120) since 7 days ago — Cayman Is.: +5 cases (now 663), +620 tests (now 124033) since 11 hours ago | 09:41 |
| Brainstorm | Updates for US Virgin Is: +143 cases (now 5556), +3 deaths (now 44) since 2 days ago | 10:06 |
| Brainstorm | New from The Indian Express: World: Cuba grants emergency approval to second homegrown vaccine → https://is.gd/Sm4Itv | 10:13 |
| Brainstorm | Updates for Puerto Rico: +1409 cases (now 136795), +10 deaths (now 2725) since a day ago — Lithuania: +790 cases (now 293342), +10 deaths (now 4481) since a day ago — West Bengal, India: +758 cases (now 1.5 million), +9 deaths (now 18346) since a day ago — Mizoram, India: +645 cases (now 51604), +2 deaths (now 192) since a day ago | 10:43 |
| Brainstorm | Updates for Russia: +21000 cases (now 6.7 million), +797 deaths (now 175282), +564002 vaccines (now 41.8 million), +500000 tests (now 174.6 million) since 23 hours ago — Slovakia: +94 cases (now 393977), +7566 vaccines (now 2.3 million), +7484 tests (now 3.3 million) since 23 hours ago | 11:08 |
| Brainstorm | New from r/WorldNews: worldnews: Duterte defending Health Secretary from Commission of Audit reports against deficiencies from the Covid-19 funds. → https://is.gd/m0RJx5 | 11:26 |
| Brainstorm | Updates for Poland: +222 cases (now 2.9 million), +1 deaths (now 75316) since a day ago | 11:33 |
| Brainstorm | Updates for Japan: +17540 cases (now 1.2 million), +33363 tests (now 20.5 million) since 9 hours ago | 12:10 |
| Brainstorm | New from Gazzetta Ufficiale italiana: MINISTERO DELLO SVILUPPO ECONOMICO - DECRETO 6 agosto 2021: Liquidazione coatta amministrativa della «Brera servizi aziendaliS.r.l. in liquidazione», in Milano e nomina del commissarioliquidatore. (21A05029) → https://is.gd/gIxMpo | 12:20 |
| Brainstorm | Updates for Slovenia: +399 cases (now 263303) since 23 hours ago — Afghanistan: +59 cases (now 152511), +15 deaths (now 7070), +149 tests (now 747735) since 20 hours ago — Germany: +7471 cases (now 3.9 million) since 23 hours ago | 12:35 |
| de-facto | .title https://www.reuters.com/lifestyle/sports/soccer-euro-2020-final-wembley-was-superspreader-event-times-2021-08-20/ | 12:40 |
| Brainstorm | de-facto: From www.reuters.com: Euro 2020 final at Wembley was a "superspreader" event | Reuters | 12:40 |
| de-facto | .title https://www.gov.uk/government/news/government-data-shows-mass-events-can-take-place-safely-but-fans-urged-to-remain-cautious-in-crowds-and-get-vaccinated | 12:40 |
| Brainstorm | de-facto: From www.gov.uk: Government data shows mass events can take place safely but fans urged to remain cautious in crowds and get vaccinated - GOV.UK | 12:40 |
| de-facto | .title https://khub.net/documents/135939561/338928724/Public+health+impact+of+mass+sporting+and+cultural+events+in+a+rising+COVID-19+prevalence+in+England.pdf/05204895-1576-1ee7-b41e-880d5d6b4f17 | 12:41 |
| Brainstorm | de-facto: From khub.net: Public Health Impact of Mass Sporting and Cultural Events in a rising COVID-19 prevalence in England (Public Health England) | 12:41 |
| Brainstorm | Updates for Austria: +1328 cases (now 675405) since 23 hours ago — Indonesia: +16744 cases (now 4.0 million), +402734 tests (now 30.4 million) since 22 hours ago — UAE: +1066 cases (now 708302), +4 deaths (now 2018), +301430 tests (now 71.6 million) since 22 hours ago — Croatia: +505 cases (now 369392), +3 deaths (now 8298), +9998 tests (now 2.5 million) since 23 hours ago | 13:00 |
| Brainstorm | Updates for Brunei: +122 cases (now 1455), +6521 tests (now 195607) since 8 hours ago — Romania: +591 cases (now 1.1 million), +15 deaths (now 34403), +40101 tests (now 11.2 million) since a day ago — Malta: +68 cases (now 35721), +1 deaths (now 436), +3247 tests (now 1.2 million) since a day ago | 13:37 |
| Brainstorm | New from The Indian Express (Health): Life-style: World Senior Citizen Day 2021: How the elderly is keeping up with ‘forced’ new normal amid pandemic → https://is.gd/qA8Az8 | 13:44 |
| Brainstorm | New from The Indian Express: World: Africa: Vaccination rollout hindered by hesitancy, low supply → https://is.gd/JkVyml | 13:55 |
| Brainstorm | Updates for Nepal: +1424 cases (now 745731), +30 deaths (now 10485), +7703 tests (now 3.8 million) since a day ago — Zambia: +359 cases (now 204337), +4 deaths (now 3573), +7086 tests (now 2.2 million) since 23 hours ago — Iceland: +73 cases (now 10053), +3940 tests (now 939457) since 22 hours ago | 14:02 |
| Brainstorm | New from Contagion Live: WHO will Test 3 Additional Drugs Repurposed to Treat COVID-19: The World Health Organization (WHO) announces the Solidarity PLUS platform trial of drugs repurposed to treat COVID-19 after Solidarity trial candidates disappoint. → https://is.gd/2scGi8 | 14:05 |
| Brainstorm | New from The Indian Express: World: Hundreds arrested, fined during Australia lockdown protests → https://is.gd/Gxp7cv | 14:37 |
| Brainstorm | Updates for Qatar: +190 cases (now 230632), +4291 tests (now 2.4 million) since 23 hours ago — Switzerland: +5 deaths (now 10941) since a day ago | 14:39 |
| Brainstorm | Updates for Denmark: +653 cases (now 336494), +201596 tests (now 79.6 million) since 21 hours ago | 15:04 |
| Brainstorm | Updates for Bangladesh: +3991 cases (now 1.5 million), +120 deaths (now 25143) since a day ago — Azerbaijan: +3551 cases (now 388437), +27 deaths (now 5279), +18982 tests (now 4.3 million) since 20 hours ago — Belarus: +1467 cases (now 468415), +11 deaths (now 3670), +18457 tests (now 7.6 million) since a day ago — Gibraltar: +9 cases (now 5278), +860 tests (now 329777) since a day ago | 15:41 |
| Brainstorm | New from Reddit (test): COVID19: Fighting COVID With COVID: Driving the Disease to Extinction With a Defective Version of the SARS-CoV-2 Virus → https://is.gd/1P7Qr0 | 15:52 |
| Brainstorm | New from Eric Topol: @EricTopol: While the debate about boosters ensues, the imminent FDA full approval will usher in millions of prescriptions by doctors for themhttps://www.wsj.com/articles/fda-poised-to-give-full-approval-of-pfizer-vaccine-next-week-11629498450?mod=hp_lead_pos1 How many of the recent increase of US vaccinations to > 1 million/day [... want %more?] → https://is.gd/ngYBUU | 16:02 |
| Brainstorm | Updates for Serbia: +1510 cases (now 741071), +11 deaths (now 7206), +11521 tests (now 4.9 million) since a day ago | 16:06 |
| Brainstorm | New from Eric Topol: @EricTopol: Throughout the pandemic, these states have tracked closely together (with the exception of the Mardi Gras superspreader). In the Delta wave, they are all still on the rise for new cases → https://is.gd/pzo3OC | 16:13 |
| Brainstorm | New from NPR: Florida Gives Schools 48 Hours To Do Away With Their Mask Mandates — Or Lose Funding: School boards in Broward and Alachua counties received a warning from the State Board of Education to walk back their decisions to require masks for all students. → https://is.gd/tEQCDR | 16:24 |
| Brainstorm | New from Contagion Live: FDA Approval on Pfizer-BioNTech COVID-19 Vaccine May Come Monday: The decision on the final federal approval in the US could mean many more people would get the vaccine. → https://is.gd/6M5DEJ | 16:45 |
| Brainstorm | New from Eric Topol: @EricTopol: Our covid times :-)by Joe Heller → https://is.gd/HQsQLi | 16:56 |
| Brainstorm | New from Retraction Watch: Weekend reads: Fraud in a study of dishonesty; scrutiny of an open access publisher; MIT/HHMI prof fired for sexual harassment: Before we present this week’s Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend [... want %more?] → https://is.gd/uBkEZw | 17:06 |
| Brainstorm | Updates for Kosovo: +2279 cases (now 127627), +8 deaths (now 2315) since 23 hours ago — Ireland: +2125 cases (now 335429) since 21 hours ago — Timor-Leste: +281 cases (now 13981), +4 deaths (now 46) since a day ago — Myanmar: +2744 cases (now 371512), +140 deaths (now 14236), +22093 tests (now 3.4 million) since 23 hours ago | 17:33 |
| LjL | pwr22, the two major ones that you can find are QWERTZ (German), and AZERTY (French), and in the latter case it doesn't end at the A/Q | 17:40 |
| LjL | %cases italy | 17:59 |
| Brainstorm | LjL: Italy has had 4.5 million confirmed cases (7.4% of all people) and 128683 deaths (2.9% of cases) as of 22 hours ago. 81.8 million tests were done (5.5% positive). 41.4 million were vaccinated (68.6%). +7220 cases, +49 deaths since a day ago. See https://www.epicentro.iss.it/en/coronavirus/sars-cov-2-dashboard or https://lab24.ilsole24ore.com/coronavirus/en/ | 17:59 |
| Brainstorm | New from Reddit (test): COVID19: Vaccine efficacy for covid-19 vaccines remains high → https://is.gd/RorP52 | 18:00 |
| LjL | well, it's not updated, in reality it's 7470, which i think is the record for this wave :\ | 18:00 |
| LjL | blah blah blah remains high | 18:00 |
| LjL | this is ridiculous, they claim Pfizer hospitalization efficacy is higher with Delta than with Alpha | 18:07 |
| LjL | it doesn't say the confidence intervals, conveniently | 18:08 |
| LjL | meanwhile the UK is going back up quick :\ | 18:08 |
| Brainstorm | Updates for United Kingdom: +31783 cases (now 6.5 million) since 15 hours ago | 18:10 |
| specing | doesen't the UK still have 30% unvaccinated? | 18:24 |
| specing | ~20 million people is still a large pool? | 18:25 |
| LjL | yes, sure, although 50%ish of the people in hospital are vaccinated | 18:26 |
| EricofSD | LjL, is that because they used the Astra Zenica? | 18:33 |
| LjL | no | 18:33 |
| LjL | it's AstraZeneca | 18:33 |
| LjL | but still no | 18:33 |
| EricofSD | thanks, yeah, I can't spell very well :P | 18:33 |
| EricofSD | We're back to wearing masks here because of the Delta and our governor has forbid masks in schools, yet schools are mandating masks anyway. | 18:34 |
| LjL | it's going to happen in the US as well, and i think it'd be high time if officials and experts there started saying it clearly, instead of trying to push vaccination with these "99% of the hospitalized are unvaccinated!" half-truths that will just be exposed when they're no longer true | 18:34 |
| EricofSD | and the City is requiring all employees to be vaccinated. | 18:34 |
| EricofSD | the US is kinda strange. Too many people here think it isn't real. | 18:37 |
| Brainstorm | Updates for Italy: +7466 cases (now 4.5 million), +45 deaths (now 128728) since 23 hours ago — Cuba: +9740 cases (now 573751), +84 deaths (now 4481), +48705 tests (now 7.4 million) since a day ago — Chile: +712 cases (now 1.6 million), +39 deaths (now 36605), +60466 tests (now 19.8 million) since 23 hours ago | 18:38 |
| EricofSD | This article is saying the vaccine (I presume they mean Pfizer and Moderna) is 95.3 percent effective on the alpha variant and 95 percent on the delta (if you get both doses). https://www.nejm.org/doi/full/10.1056/NEJMoa2108891 | 18:42 |
| Brainstorm | New from Eric Topol: @EricTopol: We're very fortunate that #SARSCoV2 monoclonal antibodies are holding up so well against even the most immune evasive variant, Beta (B.1.351)https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01123-2 @CellReports @WeizmannScience → https://is.gd/25bkJr | 18:43 |
| Brainstorm | Updates for Jordan: +428 cases (now 788516), +12 deaths (now 10285), +45099 tests (now 9.0 million) since 23 hours ago — Greenland: +2 cases (now 298), +651 tests (now 54121) since 23 hours ago | 19:03 |
| Brainstorm | New from Emma Hodcroft: @firefoxx66: A really tough thing for me this summer was having to clear my balcony plants for renovation work: gardening has meant a lot to me in the pandemic. 😢Incredibly, someone has just let me take charge of this small patch somewhere else!I'm so incredibly pleased! 🥰😁🌻🌼🌱🥬🥦 → https://is.gd/sQlwb1 | 19:05 |
| Brainstorm | New from Eric Topol: @EricTopol: This is a phenomenal accomplishment. Just think what it could have been without resistance to the most impressive biomedical triumph in history.Thanks for your indefatigable efforts @WHCOVIDResponse 🙏 → https://is.gd/He6LDj | 19:26 |
| Brainstorm | Updates for Albania: +658 cases (now 138790), +2 deaths (now 2477), +6527 tests (now 998817) since a day ago — Moldova: +376 cases (now 264283), +10 deaths (now 6356), +6560 tests (now 1.5 million) since a day ago | 19:40 |
| Brainstorm | New from Eric Topol: @EricTopol: Why do 2 states with almost the same 50% vaccination have such remarkably divergent curves for cases and hospitalizations, with Michigan being one of the lowest in the country?Supports the impact of natural infection immunity from the Alpha wave in Michigan → https://is.gd/CQuJzD | 20:08 |
| LjL | <Brainstorm> New from r/WorldNews: worldnews: On the Origins of COVID-19: Report Provides Evidence that Lab Leak Theory Unlikely → https://is.gd/3E1a84 | 20:23 |
| LjL | it links to a report in Cell | 20:23 |
| LjL | hmm, because i'm skeptical, i looked at the one Chinese-sounding name in the list of authors, and he's part of a "joint venture" university, Xi'an Jiaotong-Liverpool University: https://scholar.google.com/citations?user=CiZeoPQAAAAJ&hl=en and he wrote another paper in 2020 about the origins of the virus | 20:26 |
| LjL | then i looked at the first author listed, https://en.wikipedia.org/wiki/Edward_C._Holmes | 20:27 |
| LjL | "He is also an Honorary Visiting Professor at Fudan University, Shanghai, China (2019–present)[9]" | 20:27 |
| LjL | i guess one could argue people making such a report *must* have some ties to China or they couldn't research the origins, i guess | 20:27 |
| Brainstorm | Updates for North Macedonia: +2307 cases (now 167991), +44 deaths (now 5654) since 23 hours ago — South Africa: +13261 cases (now 2.7 million), +268 deaths (now 79251), +63830 tests (now 16.0 million) since 22 hours ago — Canada: +7 deaths (now 26790) since 22 hours ago | 20:30 |
| specing | LjL: yeah, this reeks into high heavens | 20:30 |
| specing | I'm 100% sure it was leaked (whether intentionally or unintentionally) | 20:31 |
| specing | the cover-ups and resistance to independent investigations are enough proof for me | 20:31 |
| Brainstorm | Updates for Israel: +7129 cases (now 985341), +16 deaths (now 6775) since a day ago — Morocco: +6513 cases (now 806288), +90 deaths (now 11677), +35813 tests (now 8.6 million) since 23 hours ago — Kuwait: +200 cases (now 408078), +2 deaths (now 2403), +10543 tests (now 3.7 million) since 22 hours ago | 21:07 |
| Brainstorm | New from r/WorldNews: worldnews: GoFundMe Offers $17K Refunds to Donors of Instagrammer Claiming She was 'Neurologically Damaged by Covid Vaccine' (Exclusive) → https://is.gd/fp1l5j | 21:34 |
| LjL | wut | 21:35 |
| Brainstorm | New from Eric Topol: @EricTopol: It's about time a direct counter-offensive to vaccine misinformation appeared. Good on @RWalensky, taking it on https://www.motherjones.com/politics/2021/08/cdc-director-dings-hannity-for-false-vaccine-claim/ @MotherJones by @dfriedman33 → https://is.gd/sv90XS | 21:44 |
| Brainstorm | Updates for Jamaica: +794 cases (now 61282), +15 deaths (now 1371), +2098 tests (now 529741) since a day ago — Germany: +8488 cases (now 3.9 million) since 23 hours ago — Dominica: +1 deaths (now 1) since 4 days ago — Bermuda: +35 cases (now 2750), +7434 tests (now 436268) since 3 days ago | 22:09 |
| finely[m] | <specing> "the cover-ups and resistance..." <- Those are the standard operating procedures of the CCP. It doesn't provide strong evidence one way or another. There might be a coverup just of the slow and catastrophic early response to a natural spillover event. It could just all be saving face. It could be a direct reaction to the Trumpian 'China virus' racist bullshit. | 22:19 |
| changeyourhomese | Uncensored place to talk about news info data politics in rigorous way: | 22:36 |
| changeyourhomese | Join a homeserver that doesn't censor: https://glowers.club/wiki/doku.php?id=wiki:newfriends#what_homeserver_should_i_use link to the real room: #news-info-data:nerXdsin.space Delete that big X above in the word nerds. Join diff homeserver or we won't be able read messagse, don't worry if empty it's encrypted so you can't see past messages.". Suggested server https://nerXdsin.space/#/register but any on glower list is fine. Again | 22:36 |
| changeyourhomese | delete the X in the word nerds, doing this to avoid detection from Matrix.org which has banned this server and may as result nuke this message. | 22:36 |
| finely[m] | Banned for being nazis? | 22:40 |
| changeyourhomese | nah i think i pointed out men cant have dicks i think thats what got me kicked from matrix.org | 22:41 |
| changeyourhomese | was quite a while ago though | 22:41 |
| changeyourhomese | * nah i think i pointed out women cant have dicks i think thats what got me kicked from matrix.org | 22:42 |
| changeyourhomese | sample topics we talk about: great blog on pre-maori arrival: https://tangatawhenua16.wixsite.com/the-first-ones-blog/start-here https://www.youtube.com/watch?v=PBFpGayPATs A lot of good maori accounts, inconsistent archeological finds and in the documentary unexpected DNA bringup not a smoking gun but I think strong enough pionts where it needs to be investigated more/taken seriously that the maori werent the first in new zealand. | 22:42 |
| changeyourhomese | and in general the history the peopleing of the south pacific is wrong. For example I've been sayign this for years and finally: Native American gene flow into Polynesia predating Easter Island settlement: https://www.nature.com/articles/s41586-020-2487-2 aus protests no doubt media will downplay size film from creative angles so raw videos are very important, can't let the goyim get ideas: https://www.itemfix.com/v?t=65rggc \ | 22:42 |
| changeyourhomese | https://www.latimes.com/california/story/2021-08-20/recall-candidate-larry-elder-is-a-threat-to-black-californians Black white supremacy I knew it, thank god someone is calling it out it's the new menace https://fas.org/irp/doddir/army/fm3-13-4.pdf\ | 22:42 |
| changeyourhomese | <finely[m]> "Those are the standard operating" <- you do know blacks attack asians and a much higher rate than every other race right? | 22:43 |
| * changeyourhomese uploaded an image: (111KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/QvEsSwgLFsYHFveWYWtmfMXj/14.png > | 22:43 | |
| changeyourhomese | compare that to the percetnages of the population they actually make up | 22:43 |
| changeyourhomese | also heres some SAT scores and partitioned by income level and race for you | 22:43 |
| * changeyourhomese uploaded an image: (27KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/BcXRIKEJbsvfvmGQGdBrZzZh/midclassblackshomicide.png > | 22:44 | |
| changeyourhomese | * muh income | 22:44 |
| dTal | coward | 22:54 |
| Brainstorm | Updates for Turkey: +13089 cases (now 6.2 million), +283571 tests (now 73.6 million) since 23 hours ago — Ivory Coast: +209 cases (now 53456), +9 deaths (now 389), +860 tests (now 853878) since 22 hours ago | 22:59 |
| finely[m] | The frog with the red hat told us all we needed to know. | 23:06 |
| Brainstorm | New from Eric Topol: @EricTopol: R to @EricTopol: Let me make this clear.Israel got to zero covid and is a model country for vaccination.The US, unlike Israel and the UK that suppressed 75% of hospitalizations during their Delta wave (vs Alpha), is >75% of its peak.Findings that reinforce has formidable Delta is to deal with. → https://is.gd/G0bfPd | 23:51 |
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