Brainstorm | New from r/WorldNews: worldnews: A curtain divides male, female students as Afghan universities reopen → https://is.gd/Ify3x2 | 00:05 |
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nixonix | that finnish nasal vaccine had difficulties to get financing, then secured 9M this summer. now negotiating with EMA how large trials are needed. animal challenges need to be done again because its updated for delta | 00:26 |
Brainstorm | New from r/WorldNews: worldnews: Anti-Vaxxer Attacks Health Workers Who Refused Him Vaccination Certificate → https://is.gd/TWo5Bv | 00:27 |
nixonix | how about giving them IVM badge | 00:28 |
nixonix | protected by ivermectin | 00:28 |
LjL | nixonix, that's probably about as good as giving the "got a rapid antigen test" badge | 00:31 |
LjL | (i.e. nearly worthless) | 00:31 |
nixonix | what do you mean, it cured rogan | 00:32 |
nixonix | .title https://www.newsweek.com/joe-rogan-rapid-covid-recovery-cheered-vaccine-skeptics-1626412 | 00:34 |
Brainstorm | nixonix: From www.newsweek.com: Joe Rogan's Rapid COVID Recovery Cheered by Vaccine Skeptics | 00:34 |
nixonix | oh yeah, he has never told if he got vaccinated or not | 00:34 |
nixonix | all he has said, according to media, that he was going to have jnj, but then they halted it for evaluating of those clotting things | 00:34 |
nixonix | are there countries with lots of 617.1 variant? | 00:41 |
Brainstorm | New from r/WorldNews: worldnews: India’s daily vaccination crosses 1 crore (10 million) doses, thrice in 11 days. Close to 700 million doses Administered till date. → https://is.gd/WBOz42 | 00:48 |
nixonix | .title https://www.statnews.com/2021/08/10/covid-intranasal-vaccines/ | 00:51 |
Brainstorm | nixonix: From www.statnews.com: Scientists debate potential benefits of intranasal Covid-19 vaccines | 00:51 |
nixonix | "some approaches that … look OK and I think they can be moved forward — if there’s funding,” he said. That’s a big “if,” he acknowledged, explaining that funding for next-generation Covid vaccines — innovations on the initial options — has dried up. | 00:53 |
dTal | that's ridiculous | 00:53 |
dTal | how fucking short is humanity's attention span?? | 00:54 |
nixonix | all what i wrote today? | 00:54 |
dTal | no, the last thing duh | 00:54 |
nixonix | damn, i dont get lols too often nowdays | 00:54 |
nixonix | yeah, they have problems doing trials, like in canada when ppl jumped off from even the arm that got real vaccine, to get vaccine passport | 00:57 |
nixonix | and people get real vaccine instead of a lottery ticket, like when participating in trial | 00:57 |
nixonix | trials with children are still easy. in finland somebody tried to register his kid right when it opened, but it was filled already. either fast F5 or md's had booked their kids in advance, idk | 00:58 |
nixonix | because that way their kids get a chance for protection many months earlier, so they are popular still | 00:59 |
nixonix | financing, i think a lot has to do with that its not only if it succeeds in trials, but about manufacturing. look at novavax | 01:00 |
nixonix | its a game of big pharmas | 01:00 |
nixonix | "Other experts are unclear if intranasal vaccines are of high priority at this point in the pandemic. | 01:02 |
LjL | one thing though is having trouble with finding participants, another is not even bothering with the funding and pretending the current vaccines are good enough (or you can milk their money cow for long enough) | 01:02 |
nixonix | “I think right now we’re still at the stage where we need to prevent just the basic disease. But I could imagine in the future sometime using that approach,” said Stanley Perlman, a coronavirus expert at the University of Iowa | 01:04 |
nixonix | i dont agree. with waning protection, in the future even faster waning, like vs 351, P1, 617.1 or similar when they start to spread among those with waned protection | 01:05 |
nixonix | so they would give extra protection. might be needed every couple months, so it would be a great business too imo | 01:05 |
LjL | yeah like "in the future" we'll need to deal with climate change | 01:06 |
LjL | they said, while drowning in flash floods all over the place | 01:06 |
nixonix | you dont need 100%, life is never that sure. 98% for infection would be great, then you got something like 99.8% vs hospitalization (kids more) etc | 01:07 |
nixonix | I think that a mucosal immunity will help. I’m just concerned that these are really cold viruses, even though they cause pneumonia, and you’re never going to have sterilizing immunity,” | 01:07 |
nixonix | the last one was a quote too | 01:07 |
LjL | if they think the current level of "safety" we have is enough | 01:11 |
LjL | fuck them | 01:11 |
LjL | seriously | 01:11 |
nixonix | .title https://www.nih.gov/news-events/nih-research-matters/intranasal-covid-19-vaccine-effective-animal-studies | 01:11 |
Brainstorm | nixonix: From www.nih.gov: Intranasal COVID-19 vaccine effective in animal studies | National Institutes of Health (NIH) | 01:11 |
LjL | oh lord | 01:12 |
LjL | <Brainstorm> New from r/WorldNews: worldnews: Authorities race to contain deadly Nipah virus outbreak in India → https://is.gd/oxhmvr | 01:12 |
nixonix | lets hope that prions dont attack too | 01:15 |
LjL | moo | 01:15 |
nixonix | no worries, france issued 3 months moratorium on prion research couple of months ago | 01:17 |
nixonix | .title https://www.science.org/news/2021/07/france-issues-moratorium-prion-research-after-fatal-brain-disease-strikes-two-lab | 01:18 |
Brainstorm | nixonix: From www.science.org: France issues moratorium on prion research after fatal brain disease strikes two lab workers | Science | AAAS | 01:18 |
nixonix | az nasally: "Vaccination by either route resulted in high IgG titers (25,600 to 204,800), with no difference observed between vaccination routes | 01:25 |
nixonix | "SARS-CoV-2–specific IgA antibodies were only weakly detected in nasosorption samples upon prime vaccination but further increased upon boost vaccination | 01:27 |
de-facto | .title https://timesofindia.indiatimes.com/india/explained-all-you-need-to-know-about-nipah-virus/articleshow/85967375.cms | 01:27 |
Brainstorm | de-facto: From timesofindia.indiatimes.com: Nipah virus: All you need to know about Nipah virus | India News - Times of India | 01:27 |
nixonix | pretty interesting. link me if you find a good study on some non-vector nasal vaccines | 01:29 |
nixonix | .title https://www.science.org/doi/full/10.1126/scitranslmed.abh0755 | 01:29 |
Brainstorm | nixonix: From www.science.org: Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models | 01:30 |
de-facto | Nipah is no joke, this has to be contained at all costs | 01:32 |
de-facto | https://en.wikipedia.org/wiki/Nipah_virus_infection | 01:34 |
de-facto | for each 4 infected 2-3 will not survive | 01:35 |
de-facto | https://en.wikipedia.org/wiki/2021_Nipah_virus_outbreak_in_Kerala | 01:37 |
nixonix | "PreventionAvoiding exposure to bats and to sick pigs and people. | 01:44 |
LjL | <de-facto> Nipah is no joke, this has to be contained at all costs ← absolutely strictly without exception? | 01:45 |
de-facto | its transmissible between humans, so thats a big YES | 01:50 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.06.01.21257759v2.full | 01:54 |
Brainstorm | nixonix: From www.medrxiv.org: Immunological dysfunction persists for 8 months following initial mild-moderate SARS-CoV-2 infection | medRxiv | 01:54 |
nixonix | pushd browser addon for tabs, is there such? | 02:02 |
nixonix | "While hospitalized patients with COVID-19 and vaccinees maintained sufficient neutralizing titers against all three VOCs, 39% of nonhospitalized patients exhibited no detectable neutralization against B.1.351" | 02:02 |
nixonix | lets return to the article above some day, i have to read more carefully. and maybe find some immunologists comments for it | 02:04 |
nixonix | .title https://www.science.org/doi/10.1126/sciadv.abj5365 | 02:04 |
Brainstorm | nixonix: From www.science.org: Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination | 02:04 |
de-facto | there is a plugin for zotero :) | 02:08 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.01.21262913v1.full | 02:08 |
Brainstorm | nixonix: From www.medrxiv.org: Sars-Cov-2 antibody titer 3 months post-vaccination is affected by age, gender, smoking and vitamin D | medRxiv | 02:09 |
Brainstorm | New from r/WorldNews: worldnews: Government plans October firebreak lockdown if Covid hospital admissions remain high → https://is.gd/ceQU4K | 02:23 |
Brainstorm | New from r/WorldNews: worldnews: The world ‘desperately’ needs rich countries to donate Covid vaccines, says former New Zealand prime minister → https://is.gd/V5v79p | 02:44 |
Brainstorm | New from The Indian Express: World: A curtain divides male, female students as Afghan universities reopen → https://is.gd/XhiGsv | 04:09 |
LjL | "reopen" triggers it -.- | 04:10 |
de-facto | .title https://www.medrxiv.org/content/10.1101/2021.09.02.21262861v1 <-- LjL its about Milan | 04:12 |
Brainstorm | de-facto: From www.medrxiv.org: Covid spirals: a phase diagram representation of COVID-19 effective reproduction number Rt | medRxiv | 04:12 |
de-facto | well also other regions of Italy though | 04:15 |
de-facto | .title http://virgo.unive.it/pesenti/tekwp/dashboard.php | 04:16 |
Brainstorm | de-facto: From virgo.unive.it: Dashboard Gorizia | 04:16 |
de-facto | .title https://www.nature.com/articles/s41598-021-91950-5 | 04:17 |
Brainstorm | de-facto: From www.nature.com: Metastable states in plateaus and multi-wave epidemic dynamics of Covid-19 spreading in Italy | Scientific Reports | 04:17 |
Brainstorm | New from Reddit (test): China_Flu: New Details Emerge About Coronavirus Research at Chinese Lab → https://is.gd/BIVKAC | 05:01 |
Brainstorm | New from r/WorldNews: worldnews: Israeli experts analyze mRNA COVID vaccines long-term effects → https://is.gd/bWzBzu | 05:23 |
Brainstorm | New from r/WorldNews: worldnews: Vietnamese man jailed for five years for spreading coronavirus → https://is.gd/bt0a8s | 06:04 |
Brainstorm | New from The Indian Express: World: Chile authorizes Sinovac vaccine for kids of 6 and older → https://is.gd/WiyQKY | 06:36 |
Brainstorm | New from r/WorldNews: worldnews: Vietnamese man jailed for five years for spreading COVID-19 to eight people, one who died → https://is.gd/aVTxBU | 08:32 |
Brainstorm | New from r/Coronavirus: Daily Discussion Thread | September 07, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/rv4ohp | 09:04 |
Brainstorm | New from The Indian Express (Health): Health: National Nutrition Week: Can a plant-based diet help reduce the risk of Covid? → https://is.gd/VA958S | 09:36 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Delta variant has a more diverse repertoire of mutations than other variants: mutations to the envelope, membrane, nucleocapsid, 16 non-structural proteins (NSP), and six accessory proteins (NS) of SARS-CoV-2 have been less well documented → https://is.gd/QZwivm | 09:46 |
Brainstorm | New from r/WorldNews: worldnews: Spain leads COVID world vaccination effort with 77% of fully vaccinated population → https://is.gd/qh67ah | 10:29 |
Brainstorm | New from StatNews: How the risk of side effects could change with Covid-19 vaccine boosters: What will the side effects from a Covid vaccine booster shot look like? Is there a higher or lower risk of an adverse event, compared to the earlier regimens? → https://is.gd/lHpawq | 10:39 |
Brainstorm | New from StatNews: CEPI warns of major hurdle to developing new Covid-19 vaccines and studying best booster approaches: A major hurdle stands in the way of the development of new Covid-19 vaccines, as well as the critical studies needed to determine the best way to use these important… → https://is.gd/0eotn7 | 11:11 |
Brainstorm | New from r/WorldNews: worldnews: New Details Emerge About Coronavirus Research at Chinese Lab - More than 900 pages of materials related to US.-funded coronavirus research in China were released following a FOIA lawsuit by The Intercept. → https://is.gd/mBUnvI | 11:22 |
Brainstorm | New from r/WorldNews: worldnews: Covid-19 billionaires: Meet 20 men who thrived on the pandemic → https://is.gd/BNAlky | 11:33 |
Brainstorm | New from r/WorldNews: worldnews: Delta variant outbreak threatens Singapore's 'living with Covid' model → https://is.gd/EVO80u | 11:44 |
Brainstorm | New from EMA: What's new: Event: EMA regular press briefing on COVID-19, Virtual meeting, from 09/09/2021 to 09/09/2021 → https://is.gd/ewiN09 | 11:54 |
-Bridgestorm- 🌑 Earthquake! 6.0 Mw tremor, registered by 5 agencies, occurred 17 minutes ago (09:49:57 UTC), with a new moon, Fiji Islands Region (-19.29, -176.06) ± 15 km likely felt 270 km away (in Nukuʻalofa…) by 36000 people (www.seismicportal.eu) | 12:07 | |
Brainstorm | New from PubMed: Using a theory of change to develop an integrated intervention for depression, diabetes and hypertension in Zimbabwe: lessons from the Friendship Bench project: CONCLUSIONS: The ToC can be used to build consensus on how best to use using an existing intervention for common mental disorders to integrate care for diabetes and [... want %more?] → https://is.gd/gQ7agb | 13:09 |
Brainstorm | New from r/WorldNews: worldnews: Third person dies in Japan after taking contaminated Moderna coronavirus vaccine → https://is.gd/u9E9cA | 13:31 |
Brainstorm | New from The Indian Express: World: Vietnamese man jailed for 5 years for spreading coronavirus → https://is.gd/OJj3DL | 14:47 |
Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: CEPI warns of hurdle to new Covid-19 vaccines; reading tea leaves on booster side effects → https://is.gd/gZs3AC | 15:30 |
OrTh0DoX | Any latest updates on vaccine that work against Delta variant? | 15:38 |
Juerd | OrTh0DoX: Two-dose vector and mrna vaccines seem to work very well against severe disease, even with delta. | 15:41 |
Juerd | There have been several studies showing this. I don't have links present right now. | 15:41 |
Brainstorm | New from The Indian Express (Health): Health: Study associates kidney problems with long Covid; experts share symptoms to look out for → https://is.gd/1fbg2L | 15:52 |
OrTh0DoX | I'm actually asking if there are any vaccines being worked on currently against Delta variant and even able to prevent any mild effect of the Delta variant | 15:53 |
OrTh0DoX | effects* | 15:53 |
pwr22 | I'm not aware of any vaccines in development that target delta specifically but I also likely have a very incomplete view on things | 15:57 |
Brainstorm | New from Eric Topol: @EricTopol: We have no national data for fully vaccinated people who have been hospitalized. 12% in Alabama. We need to know more: vaccine, when vaxxed, age, medical conditions, etc. @SecBecerra @HHSGov can mandate that data collection. Flying blind is unacceptable. → https://is.gd/yzeKnC | 16:25 |
Brainstorm | New from StatNews: Biotech: STAT+: STAT+ Conversation: Which biotech venture capitalist funds performed best during the pandemic? → https://is.gd/w8KHOk | 16:47 |
OrTh0DoX | ok. Hence which begs the question: Why aren't vaccine manuacturers researching and producing vaccines to specfically targetting the Delta variant which may well prevent any effects (even mild ones) of the Delta variant. Instead they are researching on weather booster shots will reduce effects of Delta variant. | 17:19 |
Brainstorm | New from Contagion Live: Second Dose of Vaccine Substantially Lowers Risk of Long COVID-19: Although the risk of contracting COVID-19 remains low post full vaccination, investigators found there was a 49% less risk with developing long COVID. → https://is.gd/lMFeTC | 17:19 |
OrTh0DoX | Addtionally, it is a well known fact that if an vaccinated individual contacted the Delta Variant, this individual will still be able to transmit the virus to another person, vaccinated or not | 17:20 |
OrTh0DoX | The key word here is prevent any effects of the delta variant, not reduce | 17:21 |
pwr22 | OrTh0DoX: Probably because no one is paying them to do it this time? That's my guess | 17:23 |
Brainstorm | New from LitCovid: (news): Staff testing for COVID-19 via an online pre-registration form. → https://is.gd/ymGwPi | 17:30 |
OrTh0DoX | It is also known that the vaccines we have are able to prevent any effect of the initial COVID-19 virus discovered in December 2019 | 17:46 |
lastshell | https://news.yahoo.com/covid-19-risk-vaccinated-people-123559748.html | 17:53 |
Brainstorm | New from Eric Topol: @EricTopol: A new systematic review of over 12 million people from 54 studies at up to 8 months following Covid. >90% prevalence of IgG antibodies, reinfection 0.2% (an 81% risk reduction) https://www.medrxiv.org/content/10.1101/2021.09.03.21263103v1 ("did not examine evidence for immunity against the new variants") → https://is.gd/B3Jj9n | 18:04 |
pwr22 | <OrTh0DoX> "It is also known that the..." <- They are quite effective but they are not 100% effective. More effective than against delta but nothing is 100% certain in life | 18:11 |
Brainstorm | New from WebMD: TikTok Creator Shortly Before COVID Death: ‘Get the Vaccine’: TikTok creator artist Alexandra Blankenbiller posted her last video on Aug. 15 from her hospital bed. Voice raspy, breathing with the help of a machine, she pleaded with her followers to get vaccinated against COVID-19. → https://is.gd/YuTd6l | 18:58 |
Brainstorm | New from Eric Topol: @EricTopol: On the list of 100 reasons for why high quality rapid home tests should be made freely and widely available, add this one.#COVIDisAirborne https://www.researchsquare.com/article/rs-775996/v1 → https://is.gd/k0pM9M | 20:13 |
LjL | sigh. https://old.reddit.com/r/worldnews/comments/pj2g1a/who_approved_first_chinese_sinopharm_vaccine_for/hbwovth/?context=3 | 20:55 |
LjL | also from the above | 20:57 |
LjL | (from WebMD above) | 20:57 |
LjL | “I don’t have a lot of energy for talking, so I’m going to try to make this quick,” said Blankenbiller, who lived in the Jacksonville, FL, area. “I did not get vaccinated. I’m not anti-vax; I was just trying to do my research. I was scared.” | 20:57 |
LjL | “I do think it was a mistake,” she continued. “I shouldn’t have waited. If you are even 70% sure you want the vaccine, go get it. Don’t wait. Go get it. Because hopefully if you get it, then you won’t end up in the hospital like me.” | 20:57 |
LjL | Nine days later, she died. She was 31. | 20:57 |
LjL | not that because she was the creator of TikTok or anything she's any more authoritative than anyone... but, look, she was young, she wasn't anti-vax, like many including some here, she just "wanted to do more research". which is understandable, but in the meanwhile SARS-COV-2 did some destructive research on her instead. | 20:58 |
nixonix | how to do bookmarks for tabs: open a tab next to the one you want to come back, and type mrk1 or something, doing a search | 21:06 |
Brainstorm | New from Derek Lowe: @Dereklowe: Too many Covid therapy trials, and especially too many bad ones:https://www.science.org/content/blog-post/awful-trials → https://is.gd/Nmhwdp | 21:06 |
nixonix | nice that they didnt go for fashionable light gray text | 21:10 |
LjL | err, i don't get it | 21:10 |
LjL | also what browser? | 21:10 |
nixonix | firefox. new tab next to the one you want to come back later (or often, if you hoard open tabs for long time). doing a google search for some unique string like mrk1, then you can later type mrk1 in url string | 21:12 |
nixonix | not needing to remember the title. and often parts of the title is not so unique in your url history | 21:13 |
LjL | ah... well i do need to remember mrk1, which can become hard if i start having many of them :P | 21:13 |
LjL | maybe i need to replace my blood with l-theanine | 21:14 |
nixonix | some browsers, depending on settings, refuse to open a new tab next to the current one, though. then there are addons for that, or a piece of js as a bookmark | 21:14 |
nixonix | .title https://twitter.com/yntieusebio/status/1435267109253222402 i wonder if this is a real md | 21:15 |
Brainstorm | nixonix: From twitter.com: Ynti Y. Eusebio MD MPH (@yntieusebio): "Tell us about reinfections. How many reinfections, age range, hospitalized, ICU and deaths. All mutations come from vaccines not from natural immunity." | 42l - [...] | 21:15 |
nixonix | thats not even bad, in dereks post, not understanding trials and their evidence. our hc officials count on anecdotal information, and even tell about it in media (we havent had many child patients) | 21:27 |
Brainstorm | New from CIDRAP: News Scan for Sep 07, 2021: COVID vaccine protection in pregnant women US COVID vaccine inequities Nipah case in India BSE ('mad cow') in Brazil H5N1 avian flu in Botswana → https://is.gd/lmLN0g | 21:27 |
nixonix | .title https://twitter.com/EricTopol/status/1435240779673264137 | 21:28 |
Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "New @NatureMedicine Vaccine effectiveness in pregnancy of 97% vs symptomatic infection in over 10,000 expectant mothers and matched controls @BioNTech_Group/@Pfizer vaccine [...] | 21:28 |
nixonix | ah there was an anecdote in daily mail, i think it was about all the vaccines, not just ronavax, interesting read, ill find it | 21:30 |
nixonix | .title https://www.dailymail.co.uk/femail/article-9964213/Covid-19-Australia-NSW-nurse-reveals-anti-vaxxer-husband-walked-got-baby-jabbed.html | 21:30 |
Brainstorm | nixonix: From www.dailymail.co.uk: Covid-19 Australia: NSW nurse reveals anti-vaxxer husband walked out after she got their baby jabbed | Daily Mail Online | 21:30 |
nixonix | "'He believed every single conspiracy theory after that,' she said. | 21:32 |
nixonix | i was thinking, maybe its how facebook works, you read some crazy shit, thinking yeah, and get new conspiracy links as a reward, producing dopamine responses. aah, more nice stuff to read. so all based on dopamine reactions rewarding | 21:35 |
nixonix | those fake ivm studies... maybe its organized? so not just some idependent researchers having found a way to gain publicity and make money then, but that somebody is paying them. who wants to see people refusing to get vaccinated. cia or something should find out | 21:43 |
nixonix | derek lowe has written lots of blogs about drug and medical trials during the years. great stuff | 21:48 |
nixonix | .title https://jamanetwork.com/journals/jama/fullarticle/2784015 | 21:54 |
Brainstorm | nixonix: From jamanetwork.com: Surveillance for Adverse Events After COVID-19 mRNA Vaccination | Vaccination | JAMA | JAMA Network | 21:54 |
nixonix | i couldnt download the pdf from jama without registering, even with all the js allowed. so i googled the title with "type:pdf", and found the direct link to the downloadable pdf file | 21:55 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.08.30.21262666v1.full | 21:59 |
Brainstorm | nixonix: From www.medrxiv.org: AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans | medRxiv | 21:59 |
nixonix | these use modified Fc's to reduce cell-mediated effector functions and extend their half-lives. i wonder if other manufacturers do the same | 22:00 |
nixonix | i mean ab mediated (used by immune cells then, though) | 22:02 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.08.26.21262699v1.full strange study, strange results | 22:05 |
Brainstorm | nixonix: From www.medrxiv.org: Prediction of vaccine efficacy of the Delta variant | medRxiv | 22:05 |
nixonix | .title https://www.biorxiv.org/content/10.1101/2021.08.31.458247v1.full also some ab differencies shown | 22:10 |
Brainstorm | nixonix: From www.biorxiv.org: Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles | bioRxiv | 22:10 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.01.21262715v1?rss=1 comprehensive immunoprofiling, and comparison between blood and upper respiratory | 22:24 |
Brainstorm | nixonix: From www.medrxiv.org: Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity | medRxiv | 22:24 |
nixonix | it looks like innate immune response is the most important in upper respiratory, if not existing immunity. neutrophil infiltration and NETs doing damage probably | 22:26 |
lastshell | maybe somebody else paste this before https://www.npr.org/sections/goatsandsoda/2021/09/07/1033677208/new-studies-find-evidence-of-superhuman-immunity-to-covid-19-in-some-individuals | 22:28 |
Brainstorm | New from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: September 7, 2021 → https://is.gd/yziEUA | 22:31 |
nixonix | doesnt help us, that wanted to avoid getting the infection without vax protection | 22:32 |
nixonix | maybe they clone those super antibodies to use as mAbs | 22:34 |
lastshell | nixonix like a plasma ? | 22:35 |
nixonix | no, as monoclonal abs, like that regeneron etc they offer in moab clinics in usa | 22:35 |
nixonix | regn2 i think is combo of two moabs, one of them affected by delta, but what i saw, not that much. and another one should be unaffected. needs to be taken early enough | 22:36 |
Brainstorm | New from CIDRAP: US COVID-19 cases top 40 million; Biden to deliver new plan: Stephanie Soucheray | News Reporter | CIDRAP News Sep 07, 2021 About 100,000 Americans are currently hospitalized because of COVID-19. → https://is.gd/k8q6YL | 22:52 |
nixonix | it would be like 3300 in finland. we have had around 100 lately (and 20 or a bit more at ICU) | 22:55 |
nixonix | ICU in different countries seem to do different things. personnel wise. here it takes lots of personnel, some of them need to have way more experience than quick orientating during this epidemic | 22:57 |
nixonix | so maybe some of our patients that are counted as ordinary hosp patients, would be counted as ICU light cases or something, in some countries | 22:58 |
nixonix | gotta ask e c k s some day, and give him links to icu doc Kuosa's comments... | 22:58 |
Brainstorm | New from r/WorldNews: worldnews: Vietnam: Man gets five years in jail for spreading Covid → https://is.gd/sbfqiv | 23:13 |
nixonix | no wonder that upper resp immunprofiling was comprehensive. florian krammer | 23:16 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.03.21263062v1 another ronavax comparison | 23:19 |
Brainstorm | nixonix: From www.medrxiv.org: Heterologous prime-boost immunization with CoronaVac and Convidecia | medRxiv | 23:19 |
nixonix | that was about using different vaxes from prime and boost | 23:20 |
Brainstorm | New from Contagion Live: Pfizer Starts Phase 3 Trial for RSV Vaccine: The first participants were vaccinated in the study of Pfizer’s respiratory syncytial virus (RSV) investigational vaccine candidate in adults ages 60 or older. → https://is.gd/Iu45qz | 23:24 |
nixonix | i think that was viral vector vax. moderna has mrna vax candidate againts rsv | 23:31 |
nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.03.21263091v1 | 23:31 |
Brainstorm | nixonix: From www.medrxiv.org: Greater Covid-19 Severity and Mortality in Hospitalized Patients in Second (Delta Variant) Wave Compared to the First: Single Centre Prospective Study in India | medRxiv | 23:31 |
nixonix | .title https://academic.oup.com/ofid/article/8/8/ofab398/6327795 | 23:33 |
Brainstorm | nixonix: From academic.oup.com: Real-world Effect of Monoclonal Antibody Treatment in COVID-19 Patients in a Diverse Population in the United States | Open Forum Infectious Diseases | Oxford Academic | 23:33 |
nixonix | "risk of ED visit or hospitalization was 82% lower in mAb-treated patients compared with untreated patients (95% CI, 56%–94%) | 23:33 |
nixonix | sorry, cut from the wrong place. "After adjusting for age, gender, and comorbidities, risk of ED visit or hospitalization was 82% lower in mAb-treated patients compared with untreated patients (95% CI, 56%–94%) | 23:35 |
nixonix | it wasnt rct, and there is about limitations. prob not that good results in rct | 23:38 |
Brainstorm | New from outbreak.info blog: user_stories: Confronting COVID-19 through the News: A Journalist’s Experience with Data During the Pandemic → https://is.gd/bkKgMY | 23:45 |
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Kids and COVID: why young immune systems are still on top ( https://www.zotero.org/groups/covid_links/items/28B5U8PF ) | 23:48 | |
nixonix | .title https://www.sportskeeda.com/mma/news-multiple-doctors-told-take-it-joe-rogan-explains-used-ivermectin-recover-covid-19 what is this claim about japan. it seems to be circulating in twitter, reddit etc, so what exactly they say if anything? | 23:53 |
Brainstorm | nixonix: From www.sportskeeda.com: Joe Rogan explains why he used ivermectin to recover from COVID-19 | 23:53 |
nixonix | maybe just that so few people in the west know japan, so almost nobody can check it... | 23:54 |
lastshell | LjL is true that obese people have a hard time to cope with Covid ? | 23:54 |
nixonix | ljl you know *japanese too? | 23:54 |
lastshell | I just scrolling and reading about the tiktok lady she looked not fit | 23:55 |
nixonix | "I literally got [Ivermectin] from a doctor. It's an American company. They won the Nobel prize in 2015 for use in human beings," Rogan said | 23:55 |
lastshell | scary that young people is dying | 23:56 |
LjL | nixonix, lastshell: antibodies like that are consistent with this study https://www.nejm.org/doi/full/10.1056/NEJMoa2108453 - in that one, it was about people who got COVID, and then a vaccine, in this one, it's about those who got SARS, and then a COVID vaccine. i guess what's in common is that the immune system is somehow being able to "compare" viruses (or vaccine) and find the weakest spots they | 23:57 |
LjL | have in common. of course getting infected with COVID first (or with SARS!) is not a good solution, but if we know these antibodies can be elicited by the body, then maybe we could build multivalent vaccines that contain the right things to elicit them | 23:57 |
LjL | NPR too says that the antibodies they found were effective against SARS, even though in that case they didn't arise *from* SARS, so that's encouraging evidence that there is more than one way to "mix" coronaviruses and obtain antibodies that work against a large subset of them | 23:57 |
LjL | いいえ | 23:58 |
LjL | lastshell, obesity is definitely a risk factor aka comorbidity | 23:58 |
lastshell | ty | 23:58 |
LjL | Nobel prizes always go nuts | 23:58 |
nixonix | is it true, that if you get nobel from a drug for some disease, it works for anything? | 23:59 |
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