| nixonix | .title https://www.news-medical.net/news/20210920/Asymptomatic-SARS-CoV-2-infections-vary-with-age-and-geographical-location.aspx | 00:11 |
|---|---|---|
| Brainstorm | nixonix: From www.news-medical.net: Asymptomatic SARS-CoV-2 infections vary with age and geographical location | 00:11 |
| nixonix | .title https://www.news-medical.net/news/20200824/Ferrets-not-susceptible-SARS-CoV-2-infection.aspx | 00:17 |
| Brainstorm | nixonix: From www.news-medical.net: Ferrets not susceptible to SARS-CoV-2 infection | 00:18 |
| Brainstorm | New from r/WorldNews: worldnews: Covid Vaccine Prompts Strong Immune Response in Younger Children, Pfizer Says → https://is.gd/EKqGPQ | 00:26 |
| nixonix | .title https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8275472/ includes stuff about the leaked pfizer documents (less intact mrna than assumed, at the time) | 00:43 |
| Brainstorm | nixonix: From www.ncbi.nlm.nih.gov: The Novel Platform of mRNA COVID-19 Vaccines and Myocarditis: Clues into the Potential Underlying Mechanism - PMC | 00:43 |
| nixonix | .title https://twitter.com/yoncabulutmd/status/1440077343406493698 | 00:46 |
| Brainstorm | nixonix, the URL could not be loaded | 00:46 |
| nixonix | .title https://twitter.com/yoncabulutmd/status/1440077343406493698 | 00:46 |
| Brainstorm | nixonix: From twitter.com: Yonca Bulut M.D. (@yoncabulutmd): "Neurological Effects of #COVID19 in Children #pedsICU #NeuroICU @PIPSQC [...] | 00:46 |
| Raf[m] | Brainstorm: Something not right with the link. Anyone have the article? | 00:46 |
| nixonix | which article? | 00:48 |
| nixonix | "In addition to the above proposed mechanisms, the neurologic effects of SARS-CoV-2 may also be related to release of inflammatory agents that can occur with systemic viremia. These inflammatory chemicals may lead to partial break down of the blood-brain barrier (BBB), thereby allowing peripheral cytokines to gain access to the CNS, which in turn | 00:48 |
| nixonix | can exacerbate or trigger neuroinflammation | 00:48 |
| nixonix | nothing about possible immune cell infiltration (induced by superantigen at fcs or not) | 00:49 |
| nixonix | .title https://www.pediatric.theclinics.com/article/S0031-3955(21)00087-0/fulltext | 00:50 |
| Brainstorm | nixonix: From www.pediatric.theclinics.com: Neurological Effects of COVID-19 in Children - Pediatric Clinics | 00:50 |
| nixonix | .title https://www.nytimes.com/2021/09/20/health/covid-children-vaccine-pfizer.html i suppose you mean this one, in that reddit link above | 00:51 |
| Brainstorm | nixonix: From www.nytimes.com: Covid Vaccine Prompts Strong Immune Response in Younger Children, Pfizer Says - The New York Times | 00:51 |
| nixonix | .title https://twitter.com/chrischirp/status/1439998800354029569 about things i have had to argue antivaxers with | 00:55 |
| Brainstorm | nixonix: From twitter.com: Prof. Christina Pagel (@chrischirp): "The govt released a detailed comparison of children admitted to hospital between wave 1 (spring 2020) and wave 2 (winter 2021) on Friday. Some things that stand [...] | 00:55 |
| nixonix | .title https://twitter.com/dgurdasani1/status/1439905677493870593 more frequent reinfections, like with common cold ronas, among kids | 00:57 |
| Brainstorm | nixonix: From twitter.com: Deepti Gurdasani (@dgurdasani1): "In summary: - young people tend to have lower seroconversion at acute stage -Abs in children less likely to be neutralising than adults -Abs in children wane faster [...] | 00:57 |
| Brainstorm | Updates for Guinea: +28 cases (now 30164), +1 deaths (now 371), +1326 tests (now 548295) since a day ago — Botswana: +2 deaths (now 2345), +15259 tests (now 1.7 million) since a day ago | 00:59 |
| nixonix | .title https://twitter.com/SighOfTheTimess/status/1439984063641759749 manchester uk prob. teacher. interesting discussion | 01:04 |
| Brainstorm | nixonix: From twitter.com: Alex (@SighOfTheTimess): "12 confirmed cases in my class of 30. Public health’s response: DO. NOT. CLOSE. I cannot believe I’m being asked to go back in tomorrow and teach a class of 18 when it’s [...] | 01:05 |
| pwr22 | https://www.dailystar.co.uk/news/world-news/four-year-old-girl-dies-24984956 | 01:17 |
| pwr22 | Poor girl 😟 | 01:17 |
| pwr22 | No guarantee that she wouldn't still have died if the having were vaccinated but it could have potentially prevented it | 01:18 |
| pwr22 | Wonder what the mum's reasons for being anti-jab were | 01:18 |
| Brainstorm | New from r/WorldNews: worldnews: Olympic gold medal swimmer Madi Wilson hospitalized with COVID-19 → https://is.gd/0PXoPi | 01:19 |
| nixonix | .title https://twitter.com/itosettiMD_MBA/status/1440088498988531715 how's the taste? | 01:21 |
| Brainstorm | nixonix: From twitter.com: Irene Tosetti (@itosettiMD_MBA): "Also for dogs against filariasis/heartworm" | 42l - nitter | 01:21 |
| LjL | pwr22, wait, snice when were 4 year olds eligible for the vaccine? O.o | 01:24 |
| wasd | LjL: might depend on geography but I haven't seen it. | 01:27 |
| grys | LjL: depends on the country; Cuba was vaccinating toddlers earlier | 01:27 |
| LjL | the article seems to be saying some in her family got COVID because they weren't vaccinated | 01:28 |
| LjL | that's a bit arguable if you ask me... sure, her mom is going to feel shitty now, but schools are open, kids are usually not even being given a remote option | 01:29 |
| LjL | so this girl could have caught COVID from the school system and died, but that would have been fine, because "the show must go on" | 01:29 |
| Brainstorm | New from r/WorldNews: worldnews: The lab leak, the missing scientists, the cover-up: Piecing together 'What Really Happened in Wuhan' → https://is.gd/454adh | 01:29 |
| LjL | but since she caught it from her unvaccinated family (who could have given it to her anyway through one of the many breakthrough infections, by the way) then everyone involved is terrible people | 01:29 |
| LjL | bit of a double standard at this point, leave this ex-mom alone | 01:30 |
| lastshell | https://www.cnbc.com/amp/2021/09/20/us-to-ease-travel-restrictions-for-foreign-visitors-who-are-vaccinated-against-covid.html | 01:33 |
| lastshell | did vaccinated people can transmit virus ? | 01:33 |
| LjL | almost certainly | 01:34 |
| LjL | they probably could even before Delta, just to a lesser extent than unvaccinated people | 01:35 |
| LjL | (a household transmission survey found about a 50% drop) | 01:35 |
| LjL | with Delta, if you've COVID, there's probably no difference in transmissibility whether you're vaccinated or not | 01:36 |
| lastshell | i guess this measure is more for economic reasons | 01:36 |
| nixonix | .title https://www.nature.com/articles/s41467-021-25509-3 this is only about hospitalized, so it would be interesting to know how is it with mild, asymptomatic etc | 01:36 |
| Brainstorm | nixonix: From www.nature.com: New-onset IgG autoantibodies in hospitalized patients with COVID-19 | Nature Communications | 01:36 |
| LjL | (but you have a lower chance of getting COVID in the first place) | 01:36 |
| nixonix | "We conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins | 01:36 |
| nixonix | "Finally, and perhaps most importantly, some autoantibodies are newly triggered by SARS-CoV-2 infection, suggesting that severe COVID-19 can break tolerance to self" | 01:36 |
| Brainstorm | Updates for Central African Rep.: +31 cases (now 11340) since a day ago — Canada: +164 cases (now 1.6 million) since a day ago — St. Kitts and Nevis: +6 cases (now 1680), +1183 tests (now 36038) since 10 hours ago | 01:37 |
| wasd | nixonix: like, auto immune disease? | 01:38 |
| nixonix | i wonder if this is only during the acute symptoms, or some of it would be permanent, like GC damage, lost immune memory, ability to gain immune memory when Bcl-6 is needed for follicular t-cell differentiation and thus b-cell maturation: | 01:38 |
| LjL | nixonix, so if they're positively correlated with response to COVID proteins, we probably don't really want full-virus vaccines, eh | 01:38 |
| nixonix | "Some patients with severe acute COVID-19 appear to mount extrafollicular B cell responses that are characterized by expanded B cells and plasmablasts, loss of germinal centers, and loss of expression of Bcl-6 | 01:38 |
| nixonix | no i dont want. less risk than with infection, but it seems E is also pathogenic, according to that one study i linked another day | 01:39 |
| nixonix | but in that quote it seems it was about strength of immune response, stronger (and/or misguided type) would result more autoantibodies | 01:41 |
| nixonix | while we still vax with unmodified furin site (some upcoming vaxes have modified it). well, we know about safety pretty well, the results count. aspiration for me, just in case... | 01:42 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: New-onset IgG autoantibodies in hospitalized patients with COVID-19 ( https://www.zotero.org/groups/covid_links/items/9V4MDDQH ) | 01:43 | |
| LjL | i don't understand the whole furin business at all | 01:43 |
| LjL | was it related to potential ADE? | 01:43 |
| LjL | %ca ade | 01:44 |
| Brainstorm | LjL, I have no idea what, who, where, when or whence that is, sorry! Try with a COVID-related thing... | 01:44 |
| nixonix | no, possible superantigen is there (i think most expert either dont believe it, or waiting for more evidence before commenting), and it makes it more cell-infectious since furin cleaves most new virions already in golgi complex, primes those viruses that has it, like sars2 | 01:45 |
| nixonix | expertS | 01:45 |
| nixonix | "More furin cuts mean more spike proteins primed to enter human cells. In SARS-CoV, less than 10% of spike proteins are primed, says Menachery, whose lab group has been quantifying the primed spike proteins but is yet to publish this work. In SARS-CoV-2, that percentage rises to 50%. | 01:50 |
| nixonix | its that PRRAR motif, which in some variants is RRRAR - not sure if it affects things like possible superantigen (it improves cleaving rate though) | 01:51 |
| nixonix | "In the Alpha variant, it’s more than 50%. In the highly transmissible Delta variant, the group has found, greater than 75% of spikes are primed to infect a human cell | 01:51 |
| nixonix | .title https://www.nature.com/articles/d41586-021-02039-y see the famous animation in this | 01:52 |
| Brainstorm | nixonix: From www.nature.com: How the coronavirus infects cells — and why Delta is so dangerous | 01:52 |
| wasd | I would have thought that's mostly the point of a virus... | 01:52 |
| nixonix | "Cleavage of the S1/S2 and S2 subunits, also known as priming, by the host proteases, is a crucial factor that determines the pathogenicity, structural flexibility, and tropism (23, 61). The cleavage site at the S1/S2 boundary also harbors a polybasic furin cleavage site, which is a hallmark of highly pathogenic viruses, such as avian influenza | 01:53 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: How the coronavirus infects cells — and why Delta is so dangerous ( https://www.zotero.org/groups/covid_links/items/VUQIK9AD ) | 01:58 | |
| nixonix | the 2nd cut at S2', which starts the fusion. but if already cut at furin site, its faster and thus faster replication: | 01:58 |
| nixonix | "SARS-CoV-2 differs from SARS-CoV because it efficiently uses TMPRSS2, an enzyme found in high amounts on the outside of respiratory cells. First, TMPRSS2 cuts a site on the spike’s S2 subunit8. That cut exposes a run of hydrophobic amino acids that rapidly buries itself in the closest membrane — that of the host cell. | 01:58 |
| nixonix | Next, the extended spike folds back onto itself, like a zipper, forcing the viral and cell membranes to fuse | 01:58 |
| nixonix | .title https://www.frontiersin.org/articles/10.3389/fimmu.2021.663912/full | 02:00 |
| Brainstorm | nixonix: From www.frontiersin.org: Frontiers | The Spike of SARS-CoV-2: Uniqueness and Applications | Immunology | 02:00 |
| Brainstorm | Updates for Papua New Guinea: +426 cases (now 18968), +8 deaths (now 212), +2666 tests (now 184534) since a day ago | 02:04 |
| wasd | I would have expected an infectious virus to infect. Is the mechanism somehow novel? | 02:05 |
| dTal | wait wait wait hold the phone | 02:07 |
| dTal | what's all this "priming" business? Covid has a built in throttle? That bumped from 50% open to 75% open with Delta? | 02:08 |
| grys | what is a throttle in context of a virus? | 02:09 |
| nixonix | viruses have different mechanisms to infect cells. some, perhaps many, have more than one. some of them more efficient than others (like sars2 has also slower cathepsin L route, and syncytia - and possibly using some other receptors instead of ace2) | 02:10 |
| Brainstorm | New from COVID tweets: Trevor Bedford (@trvrb): Last week I presented on "SARS-CoV-2 evolutionary dynamics" at the VIDD departmental seminar at @fredhutch. Slides are available here: bedford.io/talks/sars-cov… and a recording is available at youtube.com/watch?v=VErVD_…. → https://is.gd/2eFuxB | 02:11 |
| nixonix | when spikes are already cut by furin, they can infect more faster and efficiently than without the cut. it isnt necessary | 02:11 |
| nixonix | faster and more... | 02:11 |
| grys | what is furin? | 02:12 |
| nixonix | enzyme that cuts proteins | 02:12 |
| dTal | I thought all enzymes cut proteins | 02:12 |
| nixonix | somehow sars2 gained that furin cleavage site, making it more pathogenic | 02:13 |
| nixonix | that its apparent progenitor viruses didnt have | 02:13 |
| dTal | so can we expect variants that are as much of a virulence leap as delta was? | 02:13 |
| nixonix | i thought there was a ceiling already lower than with delta | 02:14 |
| de-facto | what is the probability to find an enzyme that transitions S2 into a disfunctional state that is unable to initiate membrane fusion but not be toxic for other cellular functions in vivo? | 02:15 |
| nixonix | so it would break some covalent bond in s2 before it binds to ace2. i think those parts still remain attached so it wouldnt help | 02:18 |
| de-facto | or it would trigger it so it from its metastable state or such | 02:19 |
| nixonix | there was an article they thought there was some other surface surface protein where spikes binded before rbm binds to ace2. i dont remember what it was, i think i linked it here a few days ago | 02:20 |
| de-facto | yes it also can enter cells without ACE2 | 02:20 |
| nixonix | maybe the bind wasnt as strong, but maybe there was more that protein than ace2 so it helped with ace2 bind | 02:20 |
| nixonix | yeah im not talking about cathepsin L route or those alternative receptors, but along with ace2 bind. just as a helper, i think they said | 02:21 |
| de-facto | but if the fusion with ACE2 could be destroyed enzymatically in a in-vivo-compatible way it would be a bingo i guess | 02:22 |
| nixonix | ah, found. heparin sulfate | 02:22 |
| nixonix | if you have kept reading my typings, it should be familiar (: | 02:22 |
| nixonix | "binding to heparan sulfate on the cellular membrane appears to be the mechanism of primary attachment of the virus before the high affinity interaction of the spike with the cellular ACE2 receptor | 02:23 |
| nixonix | “An important characteristic of the double mutant is that its further evolution in cultured cells appears to be unlikely,” Frolov said. He says the recombinant single mutants continued to accumulate various second-site mutations in further passages, while the double mutant that contained both the amino acid insertion and S686G was stable and | 02:24 |
| nixonix | did not acquire additional changes. | 02:24 |
| nixonix | .title https://www.eurekalert.org/news-releases/928580 | 02:25 |
| Brainstorm | nixonix: From www.eurekalert.org: The COVID-19 virus rapidly evolves to higher | EurekAlert! | 02:25 |
| nixonix | but i dont know is that more widely accepted, since i dont think ive seen that before | 02:26 |
| nixonix | ill try to find more info some day | 02:27 |
| nixonix | and it was heparAn sulfate | 02:28 |
| Brainstorm | Updates for Paraguay: +15 cases (now 459665), +4 deaths (now 16132), +2077 tests (now 1.8 million) since 18 hours ago | 02:29 |
| nixonix | ...if that is... sleep time | 02:29 |
| pwr22 | <nixonix> "when things are complex or..." <- Very wise words 🤔 | 02:41 |
| Brainstorm | New from BBC Health: Children face 'agonising' waits for mental health care: Data from half England's specialist services found a fifth have waited more than 12 weeks in the pandemic. → https://is.gd/9SuxqZ | 02:42 |
| pwr22 | <LjL> "Peter, wait, snice when were 4..." <- Not her being vaccinated but her family who all had covid and were isolating before she caught it | 02:58 |
| pwr22 | I'm less interested in an exact tit-for-tat over whether vaccination would have helped for certain (there is no certainty in most things as the wise @nixonix once said!) but more frustrated that edge case people are being forgotten / ignored in the handling of this pandemic ☹️ | 03:04 |
| Brainstorm | Updates for French Guiana: +445 cases (now 38711), +10 deaths (now 245), +2970 tests (now 385397) since a day ago | 03:06 |
| * pwr22 waves to Brainstorm | 03:07 | |
| Brainstorm | pwr22: Do as you wish! | 03:07 |
| Brainstorm | New from r/WorldNews: worldnews: Swimmer who won gold at Tokyo Olympics says she's hospitalized with COVID-19 → https://is.gd/EQZYtD | 03:24 |
| lastshell | wonder what kind of diet she has | 03:25 |
| lastshell | I recall michael phelps diet is 12,000k calories per day | 03:26 |
| lastshell | to many carbs is not good imho | 03:26 |
| LjL | *vaccinated* swimmer who won etc | 03:26 |
| lastshell | yeah | 03:27 |
| lastshell | I mean she will be fine | 03:27 |
| LjL | if she were certainly going to be fine she wouldn't need hospitalization | 03:27 |
| lastshell | I mean her body is used to get some stress | 03:28 |
| lastshell | that give her an upper hand | 03:28 |
| lastshell | however that also make me think about the importance of gut health and low carb diet is always better | 03:29 |
| pwr22 | Or she is run down and that's why she got to this point | 03:29 |
| pwr22 | We just don't know | 03:29 |
| lastshell | true | 03:29 |
| pwr22 | I suspect she will be ok with hospital treatment though | 03:29 |
| pwr22 | But maybe she might have some long term impact from this ☹️ | 03:30 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The Delta variant not only leads to higher viral RNA levels/load than prior strains of #SARSCoV2, but also increased infectivity (amount of replication competent virus per viral genome copy)medrxiv.org/content/10.110… → https://is.gd/VK3g9i | 03:35 |
| Brainstorm | New from StatNews: A hospital, and a family, lost during the pandemic: Latasha Taylor lost her mother, aunt, and uncle to Covid-19. They were scattered in hospitals across southwest Georgia, as their local hospital stopped accepting Covid patients early in the pandemic. → https://is.gd/itDRn9 | 03:46 |
| Brainstorm | New from r/WorldNews: worldnews: Germany: Gas station employee killed over a face mask → https://is.gd/cQeLU8 | 04:07 |
| Brainstorm | Updates for Peru: +845 cases (now 2.2 million), +20915 tests (now 17.5 million) since 22 hours ago — India: +264 deaths (now 445133) since 19 hours ago — Bermuda: +155 cases (now 4632), +1 deaths (now 43), +5368 tests (now 521993) since a day ago | 04:08 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): I'm going to make a layperson translation of this. Before Cov 2's Pandemic, an entity applied for DARPA funding where they would insert the very same unusual feature of SARS Cov 2 (the furin cleavage site unseen previously in it's clade) into SARS viruses that didn't have it [... want %more?] → https://is.gd/nFgjR9 | 04:39 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Alaska takes the lead in the US and is at its peak for the pandemic in cases. pic.twitter.com/bjmNKrr4M1 → https://is.gd/Y1iYBY | 04:49 |
| Brainstorm | Updates for United Kingdom: +34095 cases (now 7.5 million) since 21 hours ago — South Korea: +1727 cases (now 289263), +4 deaths (now 2413), +30309 tests (now 14.1 million) since a day ago — Australia: +1210 cases (now 87845), +4 deaths (now 1171), +199148 tests (now 36.0 million) since 23 hours ago — Fr. Polynesia: +6 deaths (now 599) since a day ago | 05:10 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Just published @ImmunityCP A unique longitudinal assessment of memory B cells w/ or w/o prior covid, vaccination, and both, and response to Deltacell.com/immunity/fullt…Prior covid + vaccine -> enhanced memory B cells, potent Delta neutralization pic.twitter.com/VAS6bzXawI → https://is.gd/epH8AS | 05:21 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): That said, a disgruntled scientist with a major platform spouting such blatant misinformation about vaccines will cost lives, prolong the pandemic and make people feel even more terrified and confused. This is beyond the pale.5/ → https://is.gd/8OmcV0 | 05:31 |
| Brainstorm | New from r/Science: science: SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans → https://is.gd/76xntf | 06:14 |
| Brainstorm | New from The Indian Express: World: Covid-19 has killed about as many Americans as the 1918-19 flu → https://is.gd/7v585i | 06:25 |
| Brainstorm | New from The Indian Express (Health): Health: Alzheimer’s care amid pandemic: All you need to know → https://is.gd/51qxt2 | 06:35 |
| Brainstorm | Updates for Belgium: +5071 cases (now 1.2 million), +20 deaths (now 25517) since a day ago — Canada: +5274 cases (now 1.6 million) since 5 hours ago — Germany: +6438 cases (now 4.2 million), +74 deaths (now 93632) since 19 hours ago | 07:03 |
| Brainstorm | New from The Indian Express: World: Johnson to Bolsonaro: vaccines save lives → https://is.gd/vDrBSW | 07:18 |
| Brainstorm | Updates for United Kingdom: +39371 cases (now 7.5 million) since 13 hours ago — Guadeloupe: +52 deaths (now 747) since a day ago — Guainia, Colombia: +12 cases (now 2283) since a day ago — Jiangsu, China: +3 cases (now 1595) since a day ago | 07:40 |
| Brainstorm | Updates for New Caledonia: +793 cases (now 4396), +8 deaths (now 33) since 21 hours ago | 08:05 |
| Brainstorm | New from r/WorldNews: worldnews: Two alleged gang associates arrested with trunk ‘full of KFC’ while attempting to enter Auckland under level-4 lockdown → https://is.gd/pKVx7a | 08:22 |
| Brainstorm | Updates for India: +26115 cases (now 33.5 million), +442 deaths (now 445311) since 23 hours ago | 08:30 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The headline tomorrow from Pfizer's press release infoand how it's ~1500 children who got the vaccine (not placebo, 2:1 randomization) pic.twitter.com/kxSG9k3PWC → https://is.gd/jgc080 | 08:32 |
| Brainstorm | New from Science-Based Medicine: Get Your Flu Shot!: COVID-19 vaccines are important, but so are flu shots. They are safe, effective, and protect others (the elderly, the immunocompromised, and those too young to get the vaccine). The post first appeared on Science-Based Medicine . → https://is.gd/NhIEYj | 09:04 |
| specing | > get your flu shot | 09:22 |
| specing | wasn't flu eradicated? | 09:23 |
| Brainstorm | Updates for Czechia: +487 cases (now 1.7 million), +11 deaths (now 30442), +74627 tests (now 37.5 million) since 22 hours ago | 09:32 |
| Brainstorm | New from r/WorldNews: worldnews: Germany: Gas station employee killed over a face mask → https://is.gd/ipm5BX | 09:36 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): >170 000 vaccine-preventable Covid deaths in the US since May (economist.com/graphic-detail… ). Resulting in Covid now having killed as many as the 1918-19 flu in the US. Solution: get vaccinated - that cuts risk to require hospitalisation or die from the virus 10-20 fold (data PHE). [... want %more?] → https://is.gd/Z72D3x | 10:19 |
| Brainstorm | Updates for Grenada: +136 cases (now 4213), +8 deaths (now 63) since 19 hours ago | 10:34 |
| Brainstorm | New from StatNews: ‘Delta has been brutal’: Covid-19 variant is decimating rural areas already reeling from the pandemic: Health inequities in rural communities across the South are continuing to determine who is most vulnerable to Covid-19 now that the Delta variant is bringing a new surge in deaths. → https://is.gd/gKKD5p | 10:41 |
| dTal | specing: no, why would you think that | 10:50 |
| specing | dTal: I have heard that there's practically no cases | 10:51 |
| Brainstorm | New from BMJ: Point-of-care tests to inform antibiotic prescribing: The tests have potential but more evidence is neededGiven the global concerns about antibiotic resistance,1 antimicrobial stewardship is essential to preserve the future effectiveness of... → https://is.gd/NmuZvD | 11:23 |
| dTal | "eradicated" does not mean "practically no cases" | 11:36 |
| Brainstorm | Updates for Slovakia: +880 cases (now 403802), +7 deaths (now 12580), +10475 tests (now 3.5 million) since a day ago — Poland: +709 cases (now 2.9 million), +15 deaths (now 75503), +67668 tests (now 20.6 million) since 23 hours ago — Germany: +6659 cases (now 4.2 million) since 23 hours ago | 11:36 |
| dTal | Only one human disease has *ever* been eradicated, and that's smallpox. | 11:36 |
| Brainstorm | New from BBC Health: Covid vaccine: India to resume vaccine exports from October: The world's largest vaccine maker halted exports in April to meet domestic demand as cases rose. → https://is.gd/myX7NM | 12:38 |
| Brainstorm | Updates for Libya: +1038 cases (now 333064), +16 deaths (now 4533), +58828 vaccines (now 1.3 million) since 22 hours ago — Australia: +1589 cases (now 88710), +105242 vaccines (now 15.1 million) since 23 hours ago — Timor-Leste: +2 deaths (now 107), +11909 vaccines (now 420827) since 23 hours ago | 13:03 |
| Brainstorm | New from r/WorldNews: worldnews: Two dose version of Johnson & Johnson shot 94% effective against Covid-19, study finds → https://is.gd/XZiqxS | 13:22 |
| Brainstorm | Updates for Romania: +6789 cases (now 1.2 million), +129 deaths (now 35721), +59686 tests (now 12.3 million) since 23 hours ago — Nepal: +1036 cases (now 786577), +5 deaths (now 11053), +9626 tests (now 4.1 million) since 23 hours ago — St. Vin. and Gren.: +15 cases (now 2845), +2 deaths (now 16) since a day ago — Brunei: +2 deaths (now 29), +5031 tests (now 312046) since 23 hours ago | 13:40 |
| aruns | How do you convince someone they should be vaccinated even if they've already had COVID? | 14:04 |
| Brainstorm | New from r/Science: science: US COVID-19 death toll surpasses that of 1918 pandemic, according to John Hopkins tracker → https://is.gd/iL0qbr | 14:04 |
| Brainstorm | New from Politico: Clinical trials: Johnson & Johnson says booster shot provides strong protection against COVID-19 → https://is.gd/HyHMsB | 14:25 |
| Brainstorm | Updates for Switzerland: +3101 cases (now 827521), +32205 tests (now 10.5 million) since 23 hours ago | 14:30 |
| Brainstorm | New from NIH Director's blog: Engineering a Better Way to Deliver Therapeutic Genes to Muscles: Amid all the progress toward ending the COVID-19 pandemic, it’s worth remembering that researchers here and around the world continue to make important advances in tackling many other serious health conditions. As an inspiring NIH-supported example, I’d [... want %more?] → https://is.gd/Nqrvog | 15:08 |
| grys | %more | 15:10 |
| Brainstorm | grys, [...] like to share an advance on the use of gene therapy for treating genetic diseases that progressively degenerate muscle, such as Duchenne muscular dystrophy (DMD). → https://paste.ee/p/4Lt8n | 15:10 |
| MerlinMp[m] | <aruns> "How do you convince someone they..." <- Same as to get 3rd and 4th shot - it will not hurt you if you`re healthy | 15:13 |
| grys | aruns, measure their antibodies, see how they fade | 15:17 |
| -Bridgestorm- 🏠 Temblor! Sismo! Earthquake! 5.5 Mb tremor, registered by alomax, with 45 reports, occurred 13 minutes ago (13:14:31 UTC), during daytime, Near Coast Of Central Chile (-36.83, -73.58) ± 32 km, ↓5 km likely felt 100 km away (in Hualpén, Concepción, Talcahuano, Coronel, Chiguayante…) by 891200 people — Webcams: https://www.windy.com/webcams/1240025112 https://www.windy.com/webcams/1468497769 (alomax.free.fr) | 15:28 | |
| Brainstorm | Updates for Iceland: +47 cases (now 11518), +11963 tests (now 1.0 million) since 22 hours ago — Denmark: +2 deaths (now 2633), +77699 tests (now 83.0 million) since 7 hours ago | 15:32 |
| de-facto | having had COVID means immunity spreads over a very wide range, some have very good immunity, others not so much, in contrast vaccinations seem to produce immunity in a more controlled way with much more reliable expectation range, hence it can make sense to vaccinate even when having had COVID | 15:46 |
| de-facto | also vaccinations boost the immune reactions to the spike protein, hence focus on the most neutralizing antigen (e.g. in contrast to nucleocapsid protein etc) | 15:47 |
| de-facto | afaik having had COVID and boosting s-protein immunity with vaccination is among the best possible protection possible today | 15:48 |
| de-facto | .title https://www.microbe.tv/twiv/twiv-802/ | 15:49 |
| Brainstorm | de-facto: From www.microbe.tv: TWiV 802: Another epitope with Shane Crotty | 15:49 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Now a randomized trial demonstrates marked protection of MMR vaccination vs Covid symptoms and need for treatment medrxiv.org/content/10.110… twitter.com/EricTopol/stat… pic.twitter.com/hF475KSxQt → https://is.gd/0Gvl08 | 15:53 |
| -Bridgestorm- ⭕ Sismo! Earthquake! 6.4 Mw tremor, registered by EMSC,GEOFON, occurred 40 minutes ago (13:14:32 UTC), during daytime, Near Coast Of Central Chile (-36.82, -73.58) ± 8 km, ↓3 km likely felt 340 km away (in Concepción, Talcahuano, Hualpén, Coronel, San Pedro de la Paz…) by 1.8 million people — Webcams: https://www.windy.com/webcams/1240025112 https://www.windy.com/webcams/1468497769 https://www.windy.com/webcams/1350018034 | 15:54 | |
| -Bridgestorm- (www.seismicportal.eu) | 15:54 | |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Another day, another vaccine company press releasestatnews.com/2021/09/21/joh… by @matthewherper @statnews This one confirming benefit of 2nd dose of J&J vaccine, as expected. → https://is.gd/3s22DB | 16:05 |
| Brainstorm | New from StatNews: Scott Gottlieb: Trump’s shadow FDA commissioner during Covid-19?: Former FDA Commissioner Scott Gottlieb writes that he briefed Trump multiple times in the early days of the Covid-19 pandemic, roughly a year after he stepped down as FDA commissioner. → https://is.gd/gsE3sy | 16:16 |
| Brainstorm | Updates for Qatar: +143 cases (now 235769), +5256 tests (now 2.6 million) since a day ago — Canada: +5365 cases (now 1.6 million) since 14 hours ago — Gibraltar: +4 cases (now 5483), +1272 tests (now 353577) since a day ago | 16:34 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Learning from major mistakes for far better pandemic preparedness, this book goes deep into what went wrong, especially at CDC, and so much we need to do to get ready for the inevitable next one. Meticulous documentation. Insider perspective. Big congrats @ScottGottliebMD twitter.com/scottgottliebm… → https://is.gd/CTezRJ | 16:39 |
| Brainstorm | Updates for Chile: +280 cases (now 1.6 million), +7 deaths (now 37374), +20338 tests (now 21.3 million) since 23 hours ago | 16:59 |
| Brainstorm | New from EMA: What's new: General: COVID-19 treatments: research and development → https://is.gd/3kka0L | 17:12 |
| Brainstorm | New from r/WorldNews: worldnews: Unvaccinated and defiant, Bolsonaro pushes back against criticism in U.N. speech. → https://is.gd/0SVioo | 17:23 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Adding Poland to a growing list, most countries giving 3rd shots irrespective of vaccine type and many for age cutoff of 50 or 60 twitter.com/EricTopol/stat… pic.twitter.com/SDwCOIRI3w → https://is.gd/ug9cBv | 17:34 |
| Brainstorm | Updates for Bangladesh: +1562 cases (now 1.5 million), +26 deaths (now 27277) since a day ago — Bhutan: +2 cases (now 2599) since 2 days ago | 17:37 |
| Brainstorm | New from COVID tweets: Ashish K. Jha, MD, MPH (@ashishkjha): Where are we on global vaccinations?Today, we'll hit 6 Billion doses into people's arms44% of the world with at least 1 shot59% of South America56% of N America56% of Europe49% of AsiaBut only 6% of AfricaWe must redouble efforts to get shots to the African people pic.twitter.com/oKv5wmsIXY → https://is.gd/uZ1rk0 | 17:45 |
| sdfgsdfg | news from last 24 hours, from the frontline country israel. Nearly 60 percent of the dead were unvaccinated. This was around 65 until about last week. More and more vaccinated people are dying if the statistics are right, are they ? | 17:51 |
| specing | sdfgsdfg: source? | 17:54 |
| sdfgsdfg | 'nearly 60 per cent' https://theprint.in/world/covid-19-pandemic-serious-cases-rise-among-unvaccinated-in-israel-cases-in-sydney-fall/736481/ | 17:54 |
| Brainstorm | New from Reddit (test): Cure domiciliari Covid. Ma come stanno veramente le cose? Ecco cosa dicono Gimbe, Patto per la scienza e Ministero della Salute: Visto che uno degli argomenti usato da coloro sfavorevoli al vaccino è la firma della consapevolezza degli eventuali effetti collaterali, e visto che questi soggetti invocano sempre le "cure precoci", [... want %more?] → https://is.gd/SlK6fM | 17:56 |
| Brainstorm | Updates for United Kingdom: +43919 cases (now 7.5 million), +1150812 tests (now 293.9 million) since 23 hours ago | 18:01 |
| ublx | sdfgsdfg: how could it be otherwise, when there are fewer and fewer people left unvaccinated? | 18:03 |
| sdfgsdfg | not in israel's case, they're stuck at the 70% mark | 18:04 |
| sdfgsdfg | not even 70, it's about 65 | 18:04 |
| Brainstorm | New from Contagion Live: Large Majority of Stem Cell Transplant Recipients Show Antibody Response to COVID-19 Vaccination: After two doses of the Pfizer-BioNTech COVID-19 vaccine, 83% of allogeneic hematopoietic stem cell transplant recipients showed positive antibody response. → https://is.gd/wjPFCf | 18:07 |
| lastshell | sdfgsdfg remember old people what the first wave of vaccination, that means they will die in general first than the rest of the population, I didn't make the game called life, im just a player | 18:09 |
| lastshell | also people don't change a vaccine doesn't change behavior, if people assume they can go with there life without social distance and not eating healthy or doing exercise well ... | 18:13 |
| sdfgsdfg | also you can actually get infected through the eyes | 18:15 |
| lastshell | eyes, skin, etc | 18:15 |
| sdfgsdfg | I have a feeling masks increase the surface contamination area | 18:15 |
| lastshell | it depends what masks and how is there use | 18:16 |
| ublx | sdfgsdfg: also the data for the last few weeks looks messy as heck, making distinctions between 60% and 65% somewhat futile | 18:16 |
| sdfgsdfg | you know that most people dont wear it properly | 18:16 |
| lastshell | yeah correct | 18:16 |
| specing | According to the chairman of the doctors association, "deksametazon" is the only effective drug for treating covid | 18:17 |
| lastshell | steroids ? | 18:18 |
| sdfgsdfg | is that a new thing for race horses :p | 18:18 |
| specing | antiinflamatory drug | 18:18 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): (7/9) Aside from the great but difficult to produce mRNA vaccines, many other technologies are readily available. E.g. intranasal live attenuated viral vaccines, pnas.org/content/118/29…, would be easy & cheap to produce & easy to deliver (no doctors or cold chain required). → https://is.gd/x8o48T | 18:29 |
| lastshell | yeah dexamethasone are steroids I knew it :D | 18:38 |
| Brainstorm | Updates for Greece: +3688 cases (now 636596), +43 deaths (now 14548), +396945 tests (now 18.4 million) since a day ago — Canada: +5576 cases (now 1.6 million), +23 deaths (now 27456) since 17 hours ago | 18:39 |
| Brainstorm | New from r/WorldNews: worldnews: Germany: Gas station employee killed over a face mask → https://is.gd/AFD9Pw | 18:40 |
| Raf[m] | <specing> "According to the chairman of the..." <- What is that spelling? | 18:46 |
| specing | Raf[m]: erm? | 18:49 |
| specing | Maybe poor translation from slovenian on my part | 18:50 |
| specing | (I made no attempt to translate drug name) | 18:50 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: We have a way out of pandemic but percentage of population is saying no, says doctor → https://is.gd/cqU0TH | 18:51 |
| lastshell | Raf[m] oh boy I'm esl I guess I will be lynched over here | 18:51 |
| Brainstorm | New from Medical Xpress: Could future coronavirus variants fully dodge our immune system?: With every new variant of SARS-CoV-2 that emerges to cause a surge in cases, a worrisome question also arises: Could the virus eventually arrive at a set of mutations that would enable it to fully evade our immune response? → https://is.gd/JYOyB6 | 19:13 |
| Brainstorm | New from COVID tweets: Richard H. Ebright (@R_H_Ebright): EcoHealth: "We will analyze..SARSr-CoV..sequences for..proteolytic cleavage sites in S2 and..potential Furin cleavage sites..[W]e will introduce..human-specific cleavage sites and evaluate growth..in Vero cells and HAE cultures." (full proposal now [... want %more?] → https://is.gd/Y221u3 | 19:34 |
| Brainstorm | Updates for Italy: +3374 cases (now 4.6 million), +67 deaths (now 130421) since a day ago | 19:41 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): To be clear: I would value input on this question not only from bioethicists, but also from pharmaceutical players, vaccinologists, virologists, medicine agencies, even politicians... Perhaps @Codagenix could also chime in? → https://is.gd/uZxXOW | 19:45 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): A clinical trial of a new covid mRNA vaccine booster that targets both the #SARSCoV2 spike and nucleocapsid proteins has begun amp.theguardian.com/society/2021/s… @OfficialUoM @MFTnhs @gritstonebio → https://is.gd/HjgzhF | 19:56 |
| Brainstorm | Updates for Greenland: +35 cases (now 504) since a day ago | 20:06 |
| Brainstorm | New from COVID tweets: Derek Lowe (@Dereklowe): There are several small-molecule coronavirus therapies in trials right now. . .but when are we actually going to hear about whether they're any good?science.org/content/blog-p… → https://is.gd/RS3Gtb | 20:17 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Vermont, #1 in the US for 69% fully vaccinated, had only 1 patient with covid in the hospital in late July. Now 48. Does this indicate 69% is not enough (80+% has been reached in several countries), waning immunity, or both? pic.twitter.com/wOgcXT0S38 → https://is.gd/qXQR5z | 20:28 |
| Brainstorm | Updates for United Kingdom: +23898 cases (now 7.5 million), +22 deaths (now 135500) since 15 hours ago | 20:31 |
| imaginary | .title https://twitter.com/michaelzlin/status/1440373910311034893 | 20:35 |
| Brainstorm | imaginary: From twitter.com: Michael Lin, PhD-MD (@michaelzlin): "Finally, ENSEMBLE2 results (2-dose J&J vaccine) have arrived. The results? Good, in a preliminary way A disappointment, in the inexplicably tiny sample sizes and [...] | 20:35 |
| imaginary | rough analysis | 20:40 |
| imaginary | is j&j dropping the ball | 20:40 |
| imaginary | sample sizes so small probably because it's just hard to find participants hah | 20:41 |
| Brainstorm | New from r/WorldNews: worldnews: Some 20% of Nigeria’s workers lost jobs to COVID → https://is.gd/LkmMNG | 20:50 |
| Brainstorm | Updates for Uganda: +128 cases (now 122405), +1 deaths (now 3130), +2612 tests (now 1.7 million) since a day ago | 21:08 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): Final graph: as an example to see what a Delta wave looks like in a country with ample access to vaccines, but poor vaccine uptake, check out Florida, where deaths & hospitalisations are now higher than at any previous point during the pandemic. twitter.com/Marco_Piani/st… → https://is.gd/BKF5qu | 21:12 |
| Brainstorm | Updates for Spain: +2450 cases (now 4.9 million), +82 deaths (now 85983) since a day ago | 21:33 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The 75+ club of the 7 countries with the highest fully vaccinated (total) populationsand their Delta wave fatality rates during the Delta wave compared with the United States (55% fully vaccinated)@OurWorldInData pic.twitter.com/XH9XJ4lGtm → https://is.gd/euKalh | 21:34 |
| Brainstorm | New from WebMD: Viruses May Jump from Bats to People More Often Than Realized: Scientists studying coronaviruses like the one that causes COVID-19 are taking blood samples from people in regions where there are lots of bats to estimate how often people encounter the viruses they carry. → https://is.gd/GO2rLW | 21:45 |
| Brainstorm | New from r/WorldNews: worldnews: Wuhan scientists planned to release coronaviruses into cave bats 18 months before outbreak → https://is.gd/yq4ael | 22:50 |
| Brainstorm | New from outbreak.info blog: Jumpstarting Community Conversations with Outbreak.info: How Scientists are Using Data to Increase COVID-19 Testing, Vaccinations, and Health Literacy in Arkansas → https://is.gd/eaQKdD | 23:22 |
| nixonix | couple of new vax papers, only had a quick look to see if there could be information on possible solution for waning problem (abs quality-wise): | 23:24 |
| nixonix | "Adjuvanted RBD and Spike-based vaccines induced significantly higher production of both Th1 (IFN-gamma, IL-2, TNF-α, IL-17A) and Th2 (IL-4, IL-5, IL-6, IL-9, IL-10) cytokines compared to antigen alone groups and control groups | 23:24 |
| nixonix | il-17 tells about follicular t-cell activation. so this would be good | 23:25 |
| nixonix | .title https://www.researchsquare.com/article/rs-902649/v1 | 23:26 |
| Brainstorm | nixonix: From www.researchsquare.com: An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission | Research Square | 23:26 |
| nixonix | .title https://www.researchsquare.com/article/rs-871537/v1 not cytokine profiles listed, but seems to include some breadth analysis | 23:27 |
| Brainstorm | nixonix: From www.researchsquare.com: SARS-CoV-2 preS dTM vaccine booster candidates increase functional antibody responses and cross-neutralization against SARS-CoV-2 variants of concern in non-human primates | Research Square | 23:27 |
| twomoon | subunit spike protein? | 23:28 |
| twomoon | what is that? | 23:28 |
| nixonix | i think they mean its not whole s-protein, or perhaps it is, but then includes something else like conserved epitopes from N or something | 23:30 |
| twomoon | isn't mRNA already "subunit"? | 23:30 |
| nixonix | usually its RBD attached to VLP, and adjuvant needed. not growing protein in cells, but they are in the vaccine, harvested from moth cells or something | 23:31 |
| nixonix | or plants like nicotina something, in that canadian | 23:31 |
| imaginary | michael lin's breakdown of j&j's new stuff lays out my concerns perfectly | 23:32 |
| nixonix | no, they dont call mrna vaxes that. even if just partial s-proteins would be produced in cells | 23:32 |
| imaginary | yall should check it out | 23:32 |
| nixonix | but type names vary, and many vaccines could be used another name instead of the one they picked | 23:32 |
| nixonix | protein vacc / subunit / recombinant / VLP etc | 23:33 |
| nixonix | .title https://twitter.com/DrEricDing/status/1440281812073209856 eric feigl-ding's take on johnson | 23:35 |
| Brainstorm | nixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "18) Folks— I’ve always said J&J was “underrated” as a vaccine. It was always a pretty decent vaccine considering it’s been a one dose out until now. Many also forgot [...] | 23:35 |
| nixonix | .title https://twitter.com/GidMK/status/1440131176665006088 this was retweeted by feigl-ding, so should be legit fellow (i linked his older analysis of ivm studies couple of times earlier) | 23:41 |
| Brainstorm | nixonix: From twitter.com: Health Nerd (@GidMK): "People promoting ivermectin keep saying "But what about Uttar Pradesh!!" as if this analysis wasn't truly woeful and totally incorrect A short thread 1/10" | nitter | 23:41 |
| nixonix | this was something really interesting. overlooked long deletions in orf8 disabling its functionality, possibly common, and overlooked because are not found easily, explaining part of mild symptoms and perhaps even outbreaks where everybody got it mild, like in some prisons? | 23:46 |
| nixonix | .title https://www.mdpi.com/1999-4915/13/9/1870/htm | 23:46 |
| Brainstorm | nixonix: From www.mdpi.com: Viruses | Free Full-Text | Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling Pipelines | HTML | 23:46 |
| nixonix | immune evasion mechanism where MHC-I is pulled inside infected cells, is in orf8. if it is removed, apparently functionality of killer t-cells and nk cells is much better | 23:49 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Why has Israel had such a tough time w/ its Delta wave?science.org/content/articl… @ScienceMagazine by @meredithwadman —Large (38%) population unvaccinated; age<12 (42% infections now)—Waning immunity from vaccines—School openings; large gatherings—Extensive testing dx of cases pic.twitter.com/7hhSJg8uzH → https://is.gd/6g6T8o | 23:55 |
| nixonix | not likely sars2 would change flu-like due to those long deletion variants becoming common. it hasnt happened. and there is probably fitness disadvantage. sometimes there can be advantage, making it evade some antibodies or cellular defences, but then it would likely become more pathogenic | 23:55 |
| twomoon | what's VLP? | 23:56 |
| nixonix | virus-like particle. some kind of nanoparticle, and antigens attached to surface | 23:57 |
| twomoon | but when you used VLP earlier did you mean a nanolipid? | 23:58 |
| nixonix | i havent checked if they all use lipids. it could be other materials too, probably, like not all the viruses have lipid envelope | 23:59 |
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