| lastshell | I will check the logs | 00:00 |
|---|---|---|
| nixonix | moderna vs pfizer? it looks like moderna gives higher circulating ab titers, and usually stats look better for moderna, but there are a few considerations that i have wrote about, like today earlier or during the last few days anyway (like moderna could perhaps benefit from even longer dose interval than pfizer) | 00:07 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.18.21263782v1 goes a bit deeper into immunopathology, i think turbo finds this interesting | 00:08 |
| Brainstorm | nixonix: From www.medrxiv.org: Alterations in CD39/CD73 Axis of T cells associated with COVID-19 severity | medRxiv | 00:08 |
| nixonix | "The expression and activity of both CD39 and CD73 changes under the pathological context of acute and chronic viral infections (9–11). In addition, CD39 expression in CD8+ T cell has also been described as a marker of exhaustion in virus infection | 00:08 |
| nixonix | "COVID-19 patients also presented higher rates of lymphocytes mitochondrial membrane depolarization and increased apoptosis rates in CD4+ and CD8+ T cells | 00:08 |
| nixonix | "higher CD39+ T cells frequency was previously associated with the expression of PD-1, confirming the hypotheses that SARS-CoV-2 infection induces an hyperactivated exhausted lymphocyte profile (33), contributing to the T cell dysfunction in COVID-19 | 00:09 |
| Brainstorm | New from COVID tweets: Bloom Lab (@jbloom_lab): Looking forward to discussing what seasonal CoV evolution might tell us about the possible future for #SARSCoV2. Along w @sarahcobey @KoelleLab @dylanhmorris, I will present a paper by Kistler & @trvrb, and another by @eguia_rachel in our group. See below for details: twitter.com/vscooper/statu… → https://is.gd/UESImR | 00:09 |
| nixonix | In severe COVID-19 patients, CD8+ T cells lacking CD73 expression possess a significantly cytotoxic effector functionality compared to CD8+CD73+ T cells, and correlates with plasma ferritin level .. CD4+CD25+CD39+ mTreg cells were decreased in mild and severe COVID-19 patients | 00:09 |
| TurboTech | Let me look at this. | 00:09 |
| TurboTech | You know what is really funny. Vitamin D really needs to be looked at as an adjuvent because that is the hormone that signals the T regs and other white blood cells. It is unfathamable to believe in this day and age they do not look at this. | 00:12 |
| TurboTech | .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164750/ | 00:12 |
| Brainstorm | TurboTech: From www.ncbi.nlm.nih.gov: Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications | 00:12 |
| nixonix | i havent read much about D and rona, but maybe its so that the benefits appear only when levels are high enough, so high they dont look at it (good equatorial level or something) | 00:14 |
| TurboTech | Problem is that they cutoff at 30ng /mL. which they deem sufficient. | 00:14 |
| TurboTech | That is the bottom of the barrel. That is not in the middle of the normal range. | 00:15 |
| nixonix | "as a doctor i cant recommend that high doses" (while making nodding gestures with head) | 00:15 |
| TurboTech | Well in studies they gave people 1000 iu which in my studies is only enough to raise the level 10ng/mL in a normal person. | 00:16 |
| TurboTech | But of course it takes 2 weeks to a month for that to get converted. Anyway. | 00:17 |
| LjL | nixonix, what's that, the medical version of Linus Torvalds denying NSA requests to backdoor the kernel | 00:18 |
| nixonix | yeah i was thinking about that while typing | 00:18 |
| TurboTech | LOL only nerds would understand that. | 00:19 |
| Brainstorm | New from r/WorldNews: worldnews: Florida governor giving the right to parents to decide if COVID positive asymptomatic children can return to school with quarantine. → https://is.gd/stqDq1 | 00:31 |
| Brainstorm | New from The Lancet (Online): [Comment] The long-term impact of COVID-19 on development assistance for health is still uncertain: The COVID-19 pandemic is continuing to have an unprecedented effect on lives, livelihoods, and economies around the world. Some experts speculate that COVID-19 will become endemic, requiring a shift from an emergency [... want %more?] → https://is.gd/eMJtL7 | 00:42 |
| TurboTech | have a great day all. Stay safe and be well | 00:59 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): If there was one person to ask our present predicament and where we're headed in the pandemic, @JeremyFarrar might indeed be the best suited. Here's our conversation with him medscape.com/viewarticle/95…w/ @cuttingforstone @Medscape w/ transcript → https://is.gd/vR3RTm | 01:14 |
| Brainstorm | New from r/WorldNews: worldnews: Brazil's Bolsonaro in COVID isolation after trip to U.N. → https://is.gd/51gTFf | 01:25 |
| nixonix | when was it when he got rona? | 01:31 |
| Brainstorm | New from FDA Press Releases: FDA Authorizes Booster Dose of Pfizer-BioNTech COVID-19 Vaccine for Certain Populations: FDA amended the emergency use authorization (EUA) for the Pfizer-BioNTech COVID-19 Vaccine to allow for the use of a single booster dose, to be administered at least six months after completion of the primary series with the [... want %more?] → https://is.gd/4PDL23 | 01:35 |
| nixonix | .title https://www.gsk.com/en-gb/media/press-releases/sk-bioscience-and-gsk-start-phase-3-trial-of-adjuvanted-covid-19-vaccine-candidate/ not sure if this has been mentioned here | 01:46 |
| Brainstorm | nixonix: From www.gsk.com: SK bioscience and GSK start Phase 3 trial of adjuvanted COVID-19 vaccine candidate | GSK | 01:46 |
| Brainstorm | New from StatNews: Breaking News: FDA authorizes Pfizer’s Covid-19 booster for people over 65 or at high risk → https://is.gd/WSUJMW | 01:46 |
| nixonix | uses GSK's AS03. i was thinking prob mclellan consulting that one too, but found somewhere that norwegians involved (CEPI or something) | 01:46 |
| nixonix | .title https://www.skbioscience.co.kr/en/news/news_01_01?mode=view&id=37 | 01:48 |
| Brainstorm | nixonix: From www.skbioscience.co.kr: SK bioscience | 01:48 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The extraordinary success of the Israeli's vaccination campaign prior to its Delta wave with reduction of infections, hospitalizations, deaths (actual vs projectedthelancet.com/journals/lanin… @TheLancetInfDis @IsraelMOH pic.twitter.com/HAdukqn9AF → https://is.gd/3THdON | 01:57 |
| Brainstorm | Updates for Fr. Polynesia: +4 deaths (now 606) since 23 hours ago | 02:03 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In both the US and England covid cases among children are at a record high. Here are the data from England, and a concern about transmission between children and parents ft.com/content/1b8849… by @mroliverbarnes @jburnmurdoch @bethanstaton pic.twitter.com/TwVSArIZDL → https://is.gd/1Tno8z | 02:07 |
| nixonix | .title https://twitter.com/long_covid/status/1436977021511421955 | 02:16 |
| Brainstorm | nixonix, the URL could not be loaded | 02:16 |
| nixonix | .title https://twitter.com/long_covid/status/1436977021511421955 | 02:17 |
| Brainstorm | nixonix: From twitter.com: Long Covid Support 🌍 (@long_covid): ""Fauci Warns of Troublesome Long-Term Effects of COVID-19 in Young People" “We’d better be careful when we say, ‘Young people who don’t wind up in the hospital are [...] | 02:17 |
| nixonix | .title https://www.theguardian.com/us-news/2021/sep/19/anthony-fauci-covid-booster-shot-fda-vote | 02:17 |
| Brainstorm | nixonix: From www.theguardian.com: Fauci: FDA vote against Covid booster shots ‘not the end of the story’ | Anthony Fauci | The Guardian | 02:17 |
| Brainstorm | New from NPR: Florida Makes Quarantine Optional For Students Exposed To COVID-19: New guidelines signed by the state's surgeon general modified the state's ban against school mask mandates, prompting a judge to dismiss a lawsuit against the old rule that had been filed. → https://is.gd/4ECVe5 | 02:18 |
| nixonix | .title https://twitter.com/kavitapmd/status/1440824523335499778 1+1+1 = just go and get that booster dose | 02:18 |
| Brainstorm | nixonix: From twitter.com: Kavita Patel M.D. (@kavitapmd): "From booster eua for @pfizer out tonite: “individuals 18 through 64 years of age whose frequent institutional or occupational exposure to SARS-CoV-2 puts them at high [...] | 02:18 |
| nixonix | "FDA amended the EUA for the Pfizer-BioNTech COVID-19 Vaccine to allow for a booster dose in certain populations such as health care workers, teachers and day care staff, grocery workers and those in homeless shelters or prisons, among others,” said Acting FDA Commissioner Janet Woodcock" | 02:24 |
| nixonix | FDA gives you linus torvalds style nod, just tell them you are among others. straight from here: | 02:25 |
| nixonix | .title https://www.fda.gov/news-events/press-announcements/fda-authorizes-booster-dose-pfizer-biontech-covid-19-vaccine-certain-populations | 02:25 |
| Brainstorm | nixonix: From www.fda.gov: FDA Authorizes Booster Dose of Pfizer-BioNTech COVID-19 Vaccine for Certain Populations | FDA | 02:25 |
| Brainstorm | Updates for Guadeloupe: +660 cases (now 53140), +26643 tests (now 444795) since a day ago — Zimbabwe: +278 cases (now 128464), +7 deaths (now 4576), +6151 tests (now 1.4 million) since a day ago — United Kingdom: +24387 cases (now 7.5 million), +134 deaths (now 135707) since 21 hours ago — Rwanda: +79 cases (now 95846), +1 deaths (now 1222), +9431 tests (now 2.7 million) since a day ago | 02:40 |
| Brainstorm | New from Reddit (test): Covid2019: 10,000+ TSA Workers Have Gotten COVID. How Many Worked At Florida Airports? → https://is.gd/PpToCl | 02:50 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Asking people to "weather" SARS-lite is damningtwitter.com/DavidSteadson/…At some point you must see it is propaganda that ends in 'selection' or culling. → https://is.gd/7qPuJP | 03:12 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Cov2 will remain Airborne DecerebrationLife expectancy will drop furthertwitter.com/fitterhappierA… pic.twitter.com/OwmvUg6mc9 → https://is.gd/KGa551 | 03:23 |
| Brainstorm | Updates for Channel Islands: +25 cases (now 11393), +3059 tests (now 904382) since 23 hours ago | 03:30 |
| Brainstorm | New from COVID tweets: JV (@JV2O21): @JT_Grindrod @fitterhappierAJ If your sister is on Facebook, she can look for "covid cautious parents" groups in her area to connect with like-minded parents. There are a lot of groups like that in the US. → https://is.gd/cqpZrK | 03:44 |
| de-facto | https://translate.google.com/translate?sl=auto&tl=en&u=https://www.overkalix.se/press/nyheter/avlidna-i-covid-19/ <-- 50% of fully vaccinated breakthroughs in elderly home died. | 03:48 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Covid tricks B cells to attack the body:nature.com/articles/s4159… → https://is.gd/jrvcpX | 03:55 |
| Brainstorm | Updates for Bermuda: +168 cases (now 4800), +2 deaths (now 45), +4074 tests (now 526067) since a day ago — Paraguay: +25 cases (now 459720), +2 deaths (now 16138), +2129 tests (now 1.8 million) since 18 hours ago | 04:07 |
| Brainstorm | Updates for South Korea: +1716 cases (now 292699), +8 deaths (now 2427), +38634 tests (now 14.2 million) since 23 hours ago | 04:32 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The side-by-side graphs are comparing vaccine efficacy (VE) from the original, large trials of Pfizer and Moderna for reduction of symptomatic illness. At the end of the blinded follow-up, there was ~10 per cent absolute difference, VE 83% (Pfizer) vs 93% (Moderna) → https://is.gd/5wiFon | 04:38 |
| LjL | "the efficacy in preventing asymptomatic infection starting 14 days after the second injection was 63.0% (95% CI, 56.6 to 68.5), with 214 cases in the mRNA-1273 group and 498 in the placebo group" | 04:55 |
| LjL | Moderna is clearly better than a kick in the balls | 04:55 |
| LjL | i don't know how much of this includes Delta infections, but, this is *a*symptomatic infection and it's not information we had before, except for AZ, and for AZ it was crap | 04:55 |
| LjL | 63% is respectable | 04:55 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase ( https://www.zotero.org/groups/covid_links/items/NR5MHIIV ) | 05:00 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel ( https://www.zotero.org/groups/covid_links/items/FU2SWWSR ) | 05:05 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: New reports @NEJM today support higher vaccine effectiveness (VE) of Moderna over Pfizer, with both providing strong level of protection 1. vs Symptomatic infection in health care personnel 96.3 vs 88.8% (see Table for 95% CI, slight overlap) http://nejm.org/doi/full/10.1056/NEJMoa2106599 https://t.co/3eLC99wnlu ( https://www.zotero.org/groups/covid_links/items/V5JN234J ) | 05:05 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: FDA Authorizes Booster Dose of Pfizer-BioNTech COVID-19 Vaccine for Certain Populations ( https://www.zotero.org/groups/covid_links/items/95H3K9FT ) | 05:05 | |
| LjL | %tell nixonix You may have left after Topol linked to a couple of key papers (at least the one about Moderna is the final phase 3 paper i guess) so see this thread https://twitter.com/EricTopol/status/1440783180915613699 | 05:08 |
| Brainstorm | LjL, I'll pass nixonix your message when they are around. | 05:08 |
| LjL | i'm not sure Leonardi making statements like "Cov2 will remain Airborne Decerebration - Life expectancy will drop further" is extremely helpful :\ | 05:09 |
| Brainstorm | New from r/WorldNews: worldnews: President Biden pledges 500m more vaccine doses to developing world → https://is.gd/3bF0EP | 05:10 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable ( https://www.zotero.org/groups/covid_links/items/V8RG4U6G ) | 05:15 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: [Untitled] ( https://www.zotero.org/groups/covid_links/items/ZPNBMJTA ) | 05:15 | |
| Brainstorm | New from r/WorldNews: worldnews: Wuhan Lab Wanted to Genetically Enhance Bat Viruses to Study Human Risks, Documents Show → https://is.gd/oD0Gbr | 05:42 |
| Brainstorm | Updates for Belgium: +2554 cases (now 1.2 million), +9 deaths (now 25533), +59623 tests (now 19.7 million) since 22 hours ago | 05:59 |
| Brainstorm | New from The Indian Express: World: Under pressure, US donates half billion more Covid-19 vaccine doses to world → https://is.gd/a0vIFX | 06:03 |
| Brainstorm | New from The Indian Express: World: Melbourne braces for anti-lockdown protests as daily Covid-19 cases hit pandemic high → https://is.gd/pJrduU | 06:13 |
| Brainstorm | New from The Indian Express: World: Brazil regulator says adolescent death unrelated to Pfizer shot → https://is.gd/uMneqz | 06:56 |
| Brainstorm | New from Science-Based Medicine: Dr. Joseph Ladapo of “America’s Frontline Doctors” is now in charge of public health in Florida: Dr. Joseph Ladapo, a member of the fringe medical group "American's Frontline Doctors" and signer of the widely criticized Great Barrington Declaration, is Florida's new Surgeon General, appointed because he agrees [... want %more?] → https://is.gd/mD5vab | 07:07 |
| Brainstorm | Updates for Santa Catarina, Brazil: +15081 cases (now 1.2 million), +27 deaths (now 19146) since a day ago — India: +31923 cases (now 33.6 million), +191 deaths (now 445758) since 23 hours ago — New Caledonia, France: +331 cases (now 4727), +16 deaths (now 49) since a day ago — Dominica: +226 cases (now 3134), +1 deaths (now 11) since 2 days ago | 07:38 |
| Brainstorm | New from The Indian Express: World: US FDA authorizes third dose of Pfizer Covid-19 vaccine for older Americans → https://is.gd/YLsCJU | 07:39 |
| Brainstorm | Updates for Mayotte: +19 cases (now 20198) since a day ago | 08:03 |
| Brainstorm | New from r/WorldNews: worldnews: Canadian police seek man who allegedly punched nurse for vaccinating his wife | Canada → https://is.gd/SjQ3nT | 08:11 |
| Brainstorm | New from BioNTech: Pfizer and BioNTech Receive First U.S. FDA Emergency Use Authorization of a COVID-19 Vaccine Booster: Emergency Use Authorization (EUA) granted for individuals 65 years of age and older, and individuals ages 18 through 64 within certain high-risk groups EUA is supported by clinical data showing a booster dose of the Pfizer-BioNTech [... want %more?] → https://is.gd/pnPdJq | 08:22 |
| Brainstorm | Updates for Grenada: +196 cases (now 4552), +10 deaths (now 85) since a day ago | 08:40 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): New story in the FT by @jburnmurdoch : "Covid cases among England's schoolchildren hit record peak". Increase in school age children also trickling through to parents. Simplest solution for those parents: get vaccinated! ft.com/content/1b8849… pic.twitter.com/LKCwwXcwRl → https://is.gd/zKgp2V | 08:54 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | September 23, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/blsn4C | 09:04 |
| Brainstorm | New from The Indian Express (Health): Fashion: Fendi opens Milan shows with disco glam, butterflies at Ferretti → https://is.gd/4FwjKV | 09:36 |
| Brainstorm | Updates for Czechia: +525 cases (now 1.7 million), +2 deaths (now 30448), +66908 tests (now 37.6 million) since a day ago | 10:07 |
| Brainstorm | Updates for New Caledonia: +555 cases (now 5282), +8 deaths (now 57) since 23 hours ago | 10:32 |
| Brainstorm | New from Medical Xpress: Diseases, Conditions, Syndromes: Is the delta variant of the coronavirus worse for kids? → https://is.gd/kxz1V7 | 10:40 |
| Brainstorm | New from r/WorldNews: worldnews: Divorced Saskatchewan parents fight in court over COVID-19 vaccination for teen daughter → https://is.gd/H1cTMs | 10:51 |
| Brainstorm | New from r/WorldNews: worldnews: More than 100 countries face spending cuts as Covid worsens debt crisis. As pandemic widens inequalities, many developing countries spend more on debt than health. → https://is.gd/EuHZL0 | 11:12 |
| Brainstorm | New from ProPublica: The Government Gave Free PPP Money to Public Companies Despite Warning Them Not to Apply: by Lydia DePillis ] ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. As Congress launched a historic bailout to keep businesses afloat at the outset of [... want %more?] → https://is.gd/nW0Vsw | 11:23 |
| Brainstorm | New from r/WorldNews: worldnews: Restaurant staff seeking proof of vaccination receive threats, verbal abuse → https://is.gd/NBoW0w | 11:33 |
| Brainstorm | New from BMJ: It is our governments’ duty to protect health: The pandemic has shown how quickly and at what scale governments can act to protect health and health services. But why should it take a pandemic to achieve this? Other clear and present threats to... → https://is.gd/530kbQ | 11:55 |
| SpearRaven | yet there are contradictions | 12:27 |
| Brainstorm | Updates for Fr. Polynesia: +4434 cases (now 44612) since 10 hours ago — Germany: +11323 cases (now 4.2 million), +52 deaths (now 93595), +94719 vaccines (now 56.1 million) since 23 hours ago — Poland: +974 cases (now 2.9 million), +14 deaths (now 75537), +36739 vaccines (now 19.7 million) since a day ago — Hong Kong: +2 cases (now 12170), +4286 vaccines (now 4.4 million) since a day ago | 12:37 |
| Brainstorm | New from Reddit (test): nCoV: Japan to donate 30 million additional COVID-19 vaccine doses | 23SEP21 → https://is.gd/yNkLRU | 12:38 |
| Brainstorm | New from Reddit (test): nCoV: Indonesia receives 684,900 AstraZeneca COVID-19 vaccine doses | 23SEP21 → https://is.gd/hWK6ho | 12:49 |
| Brainstorm | New from Reddit (test): nCoV: Over 50% of Turks have received 2 doses of COVID-19 vaccine | 22SEP21 → https://is.gd/Jr8jb2 | 12:59 |
| romare | yay thanks erdoggy | 13:00 |
| Brainstorm | Updates for Latvia: +776 cases (now 152693), +7 deaths (now 2669), +26731 tests (now 4.2 million) since 23 hours ago — Estonia: +589 cases (now 151881), +4 deaths (now 1339), +6276 tests (now 1.9 million) since a day ago — UAE: +329 cases (now 733972), +3 deaths (now 2083), +282897 tests (now 81.8 million) since 21 hours ago | 13:02 |
| Brainstorm | New from Reddit (test): nCoV: Africa: 'We Can End the Pandemic', UN Chief Says in New Call for Global Vaccine Plan | 22SEP21 → https://is.gd/h8kh5T | 13:11 |
| Brainstorm | New from ECDC: ECDC: Data for the maps in support of the Council Recommendation on a coordinated approach to the restriction of free movement in response to the COVID-19 pandemic in the EU/EEA → https://is.gd/o2qmzJ | 13:22 |
| Brainstorm | Updates for Romania: +7095 cases (now 1.2 million), +113 deaths (now 35964), +53717 tests (now 12.4 million) since a day ago | 13:39 |
| sdfgsdfg | all charts are going down | 13:45 |
| sdfgsdfg | covid is probably over soon | 13:45 |
| undefined_bob | nope | 13:46 |
| sdfgsdfg | unless, winter ??? | 13:46 |
| Trippy72894 | never vaccinated in both cases: got covid recovered then delta vs got nothing then delta chance of dying? | 13:53 |
| Trippy72894 | bottom line? | 13:53 |
| Trippy72894 | and i'm vaxed coz not an idiot by the way | 13:53 |
| Trippy72894 | so you know you can have a conversation with me | 13:54 |
| Trippy72894 | so? | 13:54 |
| Trippy72894 | what is the stats answer to that? | 13:54 |
| Trippy72894 | afk will read later for sure. have logs | 13:55 |
| sdfgsdfg | the stats are pretty clear and self explanatory. At least 35% of people who are dying are vaccinated | 13:59 |
| sdfgsdfg | and the rate is increasing over time, because less people get boosters and time is working against people's immune pool | 14:00 |
| Trippy72894 | not sure that answers my question | 14:00 |
| sdfgsdfg | it means we will have vaxx shot dispensers on streets soon, you'll shove your arm in it | 14:01 |
| Trippy72894 | i will | 14:01 |
| Trippy72894 | you? | 14:01 |
| sdfgsdfg | far deep in it | 14:01 |
| sdfgsdfg | lol joking, I wont | 14:01 |
| Trippy72894 | why not? | 14:01 |
| Trippy72894 | are you having an intelligence problem? | 14:02 |
| sdfgsdfg | I wish I was more like you | 14:03 |
| sdfgsdfg | so no | 14:03 |
| sdfgsdfg | it's a blessing though isnt it ? | 14:03 |
| Trippy72894 | let me guess, you're from wyoming | 14:03 |
| sdfgsdfg | why does someone like you even bother take a guess ? | 14:04 |
| sdfgsdfg | you like playing games little man ? | 14:04 |
| Brainstorm | Updates for Nepal: +941 cases (now 788769), +13 deaths (now 11072), +11629 tests (now 4.1 million) since 22 hours ago | 14:04 |
| Trippy72894 | true. i know you're from wyoming | 14:04 |
| Trippy72894 | wait. florida! | 14:04 |
| Trippy72894 | hahaha | 14:04 |
| undefined_bob | guys, no trolling in here, please. Take it elsewhere | 14:04 |
| Trippy72894 | thanks | 14:05 |
| sdfgsdfg | all good, he provoked me | 14:05 |
| Trippy72894 | disengaged | 14:05 |
| Trippy72894 | pls sdf don't talk to me | 14:05 |
| Trippy72894 | so, anyone have an answer to my question? | 14:05 |
| sdfgsdfg | I just wanted to say take care and do your research | 14:05 |
| sdfgsdfg | I still want to talk to you | 14:05 |
| Trippy72894 | no | 14:05 |
| undefined_bob | this isnt even a real chat channel, its more like a news channel. So please, dont disturb the silence in here. We like it silent | 14:05 |
| sdfgsdfg | ok bye | 14:06 |
| Trippy72894 | bye | 14:06 |
| Raf[m] | <undefined_bob> "this isnt even a real chat..." <- Huh? | 14:15 |
| Trippy72894 | that's what i was thinking | 14:15 |
| Brainstorm | New from Pfizer: Pfizer Declares Fourth-Quarter 2021 Dividend: Anonymous (not verified) Thu, 09/23/2021 - 08:00 Thursday, September 23, 2021 - 08:00am Board of Directors approves quarterly cash dividend of $0.39 per share NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: PFE) today announced that its board of directors declared a 39-cent fourth-quarter [... want %more?] → https://is.gd/8YF02R | 14:16 |
| Trippy72894 | it's been a fantastically educational chat for me during the past 2 years | 14:16 |
| Trippy72894 | i've shared the great comments and citations from here, with many around the world. | 14:16 |
| Trippy72894 | people here who make comments actually provide sources. that's a good thing. | 14:17 |
| undefined_bob | yes sure but its rare used for unsolicited chats | 14:19 |
| undefined_bob | most of the time its just brainstorm | 14:20 |
| Trippy72894 | ???? | 14:20 |
| Trippy72894 | tjat | 14:20 |
| undefined_bob | there are other covid realted channels for discussing | 14:20 |
| Trippy72894 | that's not so | 14:20 |
| Trippy72894 | bob, really, people have been very helpful and well informed | 14:21 |
| undefined_bob | not sure what you saw in here but I have not witnessed much chat in here, luckily | 14:21 |
| Trippy72894 | bob: when you say this is not a chat but rather a news channel, what is your source for that statement? | 14:22 |
| Trippy72894 | what you have witnessed here is not what i have seen in the last 2 years | 14:22 |
| undefined_bob | lol my source is me being here, listing to Brainstorm | 14:22 |
| Trippy72894 | sure ok | 14:23 |
| Trippy72894 | anyways..... | 14:23 |
| qkall[m] | ... i see a lot of chatting here too | 14:23 |
| qkall[m] | <_< | 14:23 |
| sdfgsdfg | life expectancy is going down | 14:23 |
| qkall[m] | i don't usually participate but i see it. | 14:23 |
| undefined_bob | are you guys from matrix? | 14:23 |
| sdfgsdfg | animals are dying | 14:23 |
| * qkall[m] be lurking | 14:23 | |
| Trippy72894 | qk cheers | 14:23 |
| undefined_bob | oh wait, yes I bet you're from #covid-19 from matrix.org | 14:24 |
| undefined_bob | thats why you say stuff like that | 14:24 |
| qkall[m] | o.o they're bridged tho | 14:24 |
| undefined_bob | the matrix channels wasnt bridged with this channel in the beginning | 14:24 |
| qkall[m] | not but it's been bridged for a couple months or so | 14:25 |
| undefined_bob | yes | 14:25 |
| undefined_bob | couple noisy month | 14:25 |
| qkall[m] | but when i was on irc in weechat | 14:25 |
| qkall[m] | sam folks talking | 14:25 |
| undefined_bob | well, like I said, I in this channel when it was on freenode and now here on libera and it was never a real chat channel because all just listened to the news. sure there was some chat now and then but not much at all. I have no idea how this channel was used on matrix.org, tho | 14:27 |
| sdfgsdfg | guys dont mind the therapy session but can we have it quiet please | 14:28 |
| sdfgsdfg | we like it quiet in here | 14:28 |
| sdfgsdfg | lets take this offline now | 14:28 |
| Trippy72894 | bob that's not true | 14:29 |
| Trippy72894 | this was used as an info channel for 2 years | 14:29 |
| Trippy72894 | i was here the whole time. plenty of discussion and debate | 14:29 |
| sdfgsdfg | go use private chat trippy | 14:29 |
| Trippy72894 | and sharing of info and links | 14:29 |
| Trippy72894 | up yours sd | 14:29 |
| sdfgsdfg | lol | 14:30 |
| Trippy72894 | go elsewhere | 14:30 |
| Trippy72894 | i'm here to discuss covid and life expectancy and have my questions answered | 14:30 |
| sdfgsdfg | you think I'm trolling ? I'm trying to help maintain our community here | 14:30 |
| sdfgsdfg | we like it quiet | 14:31 |
| Trippy72894 | no you're not. you're trying to push a point of view | 14:31 |
| sdfgsdfg | but we like it quiet | 14:31 |
| Trippy72894 | like it quiet? that's what bob said | 14:31 |
| sdfgsdfg | yeah exactly | 14:31 |
| Trippy72894 | yeah he said that because you were blabbin | 14:32 |
| Trippy72894 | now please, just standoff | 14:32 |
| Trippy72894 | and let others discuss | 14:32 |
| sdfgsdfg | I have other arguments | 14:32 |
| sdfgsdfg | in line | 14:32 |
| sdfgsdfg | we're not done yet | 14:32 |
| Trippy72894 | ok ill come back when the adults are here | 14:32 |
| sdfgsdfg | :o | 14:33 |
| qkall[m] | yeah i've was talking about libera | 14:34 |
| sdfgsdfg | I honestly think that the charts are looking good and it'll be over soon in a few months or by the end of 2022 | 14:34 |
| qkall[m] | i might still ahve logs but i don't really care | 14:34 |
| qkall[m] | i hope so but i think these couple years has me jaded on humans in general | 14:35 |
| undefined_bob | why are there always people who destroy and disturb nice things | 14:35 |
| sdfgsdfg | I don't know, some of them just balance each other out | 14:35 |
| undefined_bob | I just hate humans but my hate is not enough for all of them | 14:35 |
| qkall[m] | i have the masses but individuals can prove otherwise | 14:36 |
| sdfgsdfg | just trying to cheer you up bobbb, chill outtt | 14:36 |
| Brainstorm | New from r/WorldNews: worldnews: COVID-19: Man accused of repeatedly punching nurse in face for giving wife vaccine → https://is.gd/jvG0rc | 14:48 |
| Brainstorm | Updates for Denmark: +3 deaths (now 2638), +77009 tests (now 83.2 million) since 12 hours ago | 15:06 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Pfizer CEO rallies employees to fight drug-price negotiations; Glaxo head pressured by another activist fund → https://is.gd/dqCC2Z | 15:21 |
| Brainstorm | Updates for Switzerland: +1086 cases (now 831337) since 23 hours ago | 15:31 |
| Brainstorm | New from Novavax: (news): Novavax and Serum Institute of India Announce Submission to World Health Organization for Emergency Use Listing of Novavax' COVID-19 Vaccine → https://is.gd/vIwFyZ | 15:32 |
| `St0ner | https://www.nationalgeographic.com/science/article/covid-19-may-impair-mens-sexual-performance | 15:45 |
| Brainstorm | New from Politico: Health worker eyed in leak of Macron COVID-19 immunity data: French officials have identified dozens of health care workers who had access to the president's vaccination status. → https://is.gd/auq2aC | 16:04 |
| Brainstorm | Updates for Uganda: +89 cases (now 122591), +2 deaths (now 3137), +3790 tests (now 1.7 million) since 23 hours ago — Zambia: +39 cases (now 208715), +2 deaths (now 3641), +6084 tests (now 2.4 million) since 23 hours ago | 16:08 |
| Brainstorm | New from COVID tweets: gianluca c 🏴☠️🇻🇪 #TeamFauci #MaskUp #no papers (@gianlucac1): Prison (Out-)BreakVE infection dropping point (cliff) confirmed at my original estimate of 4.5 months (below 20%)Delta vs Pfizer/Moderna@ThManfredi @mtizzoni @Di_SPACE_Lauro @OpencovidM @fitterhappierAJ @ChristosArgyrop @manlius84 @FabrizioChiodo [... want %more?] → https://is.gd/bvHbp2 | 16:15 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): How to make a Delta variant specific vaccinewsj.com/articles/covid… good schematic by @joshulick @acervantesc pic.twitter.com/U1emAcEGwa → https://is.gd/i48C28 | 16:26 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In the past 3 weeks, US hospitalizations have declined by 15% from their 4th wave peak--90% of these were preventable w/vaccination--marked geographic variability--still at an extremely high level pic.twitter.com/MTmqQsjORu → https://is.gd/UZsRuh | 16:48 |
| notK | its beyond time for Joe Biden to get tough on Covid | 16:50 |
| notK | Joe Biden needs to suspend the constitution, enact a strict 36 month lockdown with forced vaccinations, and permanent mask mandates | 16:50 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The big picture on the pandemic@JeremyFarrar in conversationmedscape.com/viewarticle/95…w/ transcript → https://is.gd/KMFv1Y | 16:59 |
| LjL-Matrix | Lol, Twitter's "no js" message I see from Matrix is... appropriate | 17:07 |
| LjL-Matrix | "Something went wrong, but don't fret - let's give it another shot." | 17:07 |
| LjL-Matrix | %title https://mobile.twitter.com/fitterhappierAJ/status/1441042305457303552 meanwhile first, greatly uplifting first COVID tweet of the day for me | 17:08 |
| Brainstorm | LjL-Matrix: From mobile.twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "The virus won't be benign The trajectory has been more immune-evasive (chronic), with retention of the superantigen, fcs, and refinement of fcs [...] | 17:08 |
| LjL-Matrix | I thought Leonardi was yelling at someone just yesterday for suggesting we should let the virus select the fit among us | 17:08 |
| LjL-Matrix | Maybe I misinterpreted, or maybe he gets upset if someone suggests not trying to avoid what he considers the inevitable anyway... | 17:09 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Great explainer by @Craig_A_Spencer on the differences of contagiousness between vaccinated and unvaccinated people theatlantic.com/ideas/archive/… @TheAtlantic → https://is.gd/x3OzZf | 17:10 |
| LjL-Matrix | Is there anything like "negativity bias"? Being more likely to unquestioningly believe statements with negative implications than positive | 17:11 |
| notK | I just want strict 36 month lockdowns in the U.S. | 17:11 |
| pwr22 | LjL-Matrix: Yes, but positivity in general is more often displayed by humans 😛 | 17:12 |
| pwr22 | Thinking Fast and Slow is a very interesting book on cognitive bias | 17:13 |
| LjL-Matrix | "To spread the coronavirus, you have to have the coronavirus. And vaccinated people are far less likely to have the coronavirus—period." Far less? 20% if you ask the optimist? 60% if you ask Israel? What is "far less"? 95% would have been far less | 17:15 |
| LjL-Matrix | "At the wedding with exclusively vaccinated attendees, however, the likelihood that anyone present has COVID-19 is minuscule." This is just misleading and wrong | 17:16 |
| pwr22 | At a population level even a 10% change would be meaningful | 17:17 |
| LjL-Matrix | "Some may also develop long COVID, although thankfully the shots dramatically lower this risk too." Dramatically! 50%? | 17:19 |
| notK | even with the jab | 17:21 |
| notK | we still need 36 month lockdowns | 17:21 |
| notK | and permanent mask mandates | 17:21 |
| Brainstorm | New from r/WorldNews: worldnews: A ‘Get COVID party’ sends Edson, Alberta residents to Edmonton ICU → https://is.gd/RuaLKR | 17:22 |
| notK | that Covid party should send them to prison for life as well. | 17:22 |
| LjL-Matrix | Peter: "meaningful" doesn't have the same connotation as "far less" or "dramatically" | 17:22 |
| Brainstorm | Updates for Bangladesh: +1144 cases (now 1.5 million), +24 deaths (now 27337) since a day ago — Chile: +859 cases (now 1.6 million), +31 deaths (now 37410), +69628 tests (now 21.4 million) since 23 hours ago | 17:35 |
| Brainstorm | New from BBC Health: UK Covid vaccine rules cause hesitancy - Africa health chief: The UK's refusal to accept vaccine certificates from Africa could increase hesitancy, says Africa CDC. → https://is.gd/9WTG1l | 17:43 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: COVID-19 could cause male infertility and sexual dysfunction – but vaccines do not. New research has found that some men who have had COVID-19 might experience unwanted sexual side effects. A study of 45 men showed the Pfizer and Moderna mRNA vaccines appear safe for the male reproductive system. → https://is.gd/BlJmNW | 17:54 |
| Brainstorm | Updates for United Kingdom: +34381 cases (now 7.6 million), +171 deaths (now 135795), +1016943 tests (now 295.9 million) since 23 hours ago — Canada: +51 deaths (now 27559) since 23 hours ago | 18:00 |
| Brainstorm | New from Politico: Aid and development: EU regulators should decide on coronavirus vaccine for kids by early November → https://is.gd/49Hr65 | 18:05 |
| Brainstorm | New from r/WorldNews: worldnews: Twelve-year-old Dutch boy wins right to be vaccinated, against his father's wishes → https://is.gd/imLhXt | 18:16 |
| Brainstorm | New from Our World In Data: Which countries are on track to reach global COVID-19 vaccination targets?: Based on our international COVID-19 vaccination data, we publish projections of which countries are on-track to achieve this. → https://is.gd/MrbMfB | 18:27 |
| Brainstorm | New from Contagion Live: Booster Vaccinations in Israel Increased Protection against COVID-19: A third dose booster vaccination given to persons 60 years of age or over in Israel was confirmed to lower their rate of COVID-19 infection compared to a 2-dose regimen. → https://is.gd/YWaBbS | 19:12 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): There is currently only 1 source of data for 3rd dose (booster) vaccine effectiveness, and only 1 vaccine (Israel, Pfizer)So how does Moderna get an EUA with only data on immune response but without clinical outcomes? → https://is.gd/VJ0dTo | 19:34 |
| Brainstorm | Updates for Italy: +4053 cases (now 4.6 million), +63 deaths (now 130551) since a day ago — Jordan: +913 cases (now 817487), +8 deaths (now 10645), +30650 tests (now 9.9 million) since a day ago | 19:39 |
| Brainstorm | Updates for Greenland: +13 cases (now 541), +1029 tests (now 71746) since a day ago | 20:04 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): Nice compilation of Covid vaccine effectiveness by vaccine, dose & variants by @IVACtweetsThis forest plot of the effectiveness of the Pfizer, Moderna and AZ vaccines, as well as their effectiveness against Delta, was updated on Sept 16th.view-hub.org/sites/default/… pic.twitter.com/yTMWMNrbZo → https://is.gd/FLHZ07 | 20:06 |
| Brainstorm | New from r/WorldNews: worldnews: Canadians End Up In ICU After Attending ‘Covid Party’ → https://is.gd/Lzcblu | 20:16 |
| notK | I hope Trudeau has those party goers mining diamonds in gulags | 20:19 |
| Brainstorm | Updates for Spain: +3031 cases (now 4.9 million), +100 deaths (now 86185) since 23 hours ago — Greece: +2101 cases (now 641022), +31 deaths (now 14606), +151279 tests (now 18.8 million) since a day ago | 20:29 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Just published @ScienceMagazineHow do we get better antibodies and vaccines vs #SARSCoV2? A global consortium effort to define all the problematic epitopes that can give our immune response troublescience.org/doi/10.1126/sc…by @EOSaphire and collaborators @ljiresearch pic.twitter.com/Ge1npYx4tn → https://is.gd/cUQzIE | 20:38 |
| Brainstorm | Updates for Djibouti: +46 cases (now 12253), +3 deaths (now 162), +713 tests (now 217089) since 22 hours ago | 21:07 |
| Brainstorm | New from StatNews: Listen: Scott Gottlieb on the next pandemic, another Covid winter, & Aduhelm’s slow rollout: What does Covid-19 have in store for this winter? Is Aduhelm a commercial dud? And are we prepared for the next pandemic? All that and more on the latest episode… → https://is.gd/a2UItU | 21:43 |
| breakthroughvax | .title https://www.cbsnews.com/news/covid-case-decline-us-scott-gottlieb-face-the-nation/ april 26th | 21:48 |
| Brainstorm | breakthroughvax: From www.cbsnews.com: Drop in COVID cases a "hopeful trend" that U.S. can "take to the bank," former FDA head Gottlieb says - CBS News | 21:48 |
| notK | doesn't matter | 21:49 |
| notK | we need strict 36 month lockdowns | 21:49 |
| notK | permanent mask mandates | 21:49 |
| notK | and forced vaccinations | 21:49 |
| breakthroughvax | is there an alternative to those? | 21:54 |
| notK | no | 21:58 |
| notK | there isn;t | 21:58 |
| notK | freedom has failed | 21:58 |
| breakthroughvax | so you are saying we should all vax to reduce the damage of that all? | 22:00 |
| Brainstorm | New from CIDRAP: News Scan for Sep 23, 2021: Adult COVID-19-related syndrome Israeli COVID vaccination and lives saved → https://is.gd/xcYebK | 22:04 |
| breakthroughvax | it seems some people are prone to develop immune complexes consisting of several IgGs and antigens, and according to a recent study Fc gamma receptors of monocytes (and platelets? they have a role as immune cells too) can somehow sense it and get more triggered | 22:18 |
| breakthroughvax | nk cells, macrophages with cd16, neutrophils | 22:20 |
| breakthroughvax | .title https://www.biorxiv.org/content/10.1101/2021.06.25.449893v4 remind turbo | 22:20 |
| Brainstorm | breakthroughvax: From www.biorxiv.org: Circulating multimeric immune complexes drive immunopathology in COVID-19 | bioRxiv | 22:20 |
| breakthroughvax | .title https://twitter.com/farid__jalali/status/1440876997182300169 here some dude that seems to have done research close to the subject, describes that paper and some of their research | 22:22 |
| Brainstorm | breakthroughvax: From twitter.com: Farid Jalali MD (@farid__jalali): "Updated 🧵 on pathophysiology of COVID-19: We have had numerous descriptive studies, highlighting what we "see" as different in this disease. Examples include [...] | 22:22 |
| breakthroughvax | Specifically, CD16 is able to sense circulating soluble immune complexes (sICs) as they are formed in certain autoimmune diseases such as systemic lupus erythematosus (SLE) (22-25) and viral infections (26). Overstimulation of activating FcγRs in these cases is associated with disease severity (26-28) and thus an FcγR-driven overshooting | 22:24 |
| breakthroughvax | inflammatory response (18) might be an explanation for the pronounced immunopathology | 22:24 |
| notK | we should all vax yes | 22:25 |
| notK | and take any and all boosters that are even so much as vaguely suggested | 22:26 |
| Arsanerit | notK doing sarcasm? | 22:26 |
| notK | I'm dead serious | 22:26 |
| Brainstorm | New from StatNews: Advisory committee recommends wide swath of Americans be offered Covid-19 vaccine boosters: The Advisory Committee on Immunization Practices, or ACIP, recommended that Covid-19 booster shots be offered to adults 65 and older as well as to individuals 50-64 with underlying health conditions. → https://is.gd/914l4h | 22:26 |
| Arsanerit | of course you are | 22:26 |
| notK | well | 22:27 |
| notK | do you want to die from Covid? | 22:27 |
| notK | because the alternative is dying from Covid | 22:27 |
| Arsanerit | I am fully vaccinated, I don't need a 36 month lockdown to not die from covid. | 22:28 |
| Arsanerit | Being fully vaccinated, I am very unlikely to die from covid. | 22:28 |
| Arsanerit | And spare doses should go to unvaccinated people, not to a booster Idon't need yet. | 22:29 |
| Arsanerit | Others need that dose more urgently than I do. | 22:29 |
| specing | they don't want those doses | 22:30 |
| specing | so why not use them for boosters before they expire? | 22:30 |
| Arsanerit | Hundreds of millions of people in Africa are very much wanting those doses. | 22:30 |
| specing | they can't afford mRNA anyway | 22:30 |
| specing | AZ & J&J are already being sent there | 22:31 |
| specing | and they can't store/handle mRNA either | 22:31 |
| Arsanerit | Rich countries can donate mRNA vaccines to poor countries. | 22:31 |
| specing | you need -80'C fridges for that | 22:31 |
| Arsanerit | Yes, they can donate those too. | 22:31 |
| specing | lol | 22:31 |
| Arsanerit | It's in the self-interest of rich nations to donate vaccines to poor nations. | 22:32 |
| specing | it's in the interest of any nation to vaccinate themselves first | 22:32 |
| specing | my country already donates AZ shots like candy | 22:33 |
| specing | because it would just expire otherwise | 22:33 |
| specing | and we sent 100k doses of BNT to BiH today | 22:33 |
| Arsanerit | Yes, help yourself before you help others. | 22:34 |
| breakthroughvax | it seems those immuno complexes are unique for sars2 for some reason (formed by several Y-shaped IgGs that connect antigens, meaning spikes of sars2 virions). and they appear on individuals that are prone to those formations, in around 7th day | 22:34 |
| Arsanerit | But by now many rich countries have (much) more vaccine than they need. | 22:35 |
| breakthroughvax | leading to severe condition. platelet-monocyte aggregation, dysregulated immune response etc | 22:35 |
| nixonix | anyways, if you are vaxed and its still recent enough, immune memory should be able to clear it before it happens | 22:38 |
| Brainstorm | nixonix: At 2021-09-23 03:08:09 UTC, LjL told you: You may have left after Topol linked to a couple of key papers (at least the one about Moderna is the final phase 3 paper i guess) so see this thread https://twitter.com/EricTopol/status/1440783180915613699 | 22:38 |
| LjL | it's not really -80°C anymore to be fair | 22:38 |
| twomoon | well it's still tricky to deal with | 22:38 |
| nixonix | those things are their hypothesis, with some previous evidence apparently supporting it, but needs to be confirmed by other research. they didnt find out what would cause that formation of those complexes (genetics... would be the old answer - but i think there could be something else too, otherwise the course would be always the same for twins - | 22:42 |
| nixonix | when getting systemic infection) | 22:42 |
| nixonix | although i dont remember seeing any twin studies. should try to find | 22:42 |
| imaginary | LjL: interesting thread | 22:44 |
| imaginary | oh those are pre-delta numbers :( | 22:45 |
| nixonix | sensitivity to those complexes? how can they know it anyway, if its single IgG or part of complex, like magic... | 22:46 |
| LjL | imaginary, they may include some delta but they are general | 22:46 |
| imaginary | LjL: moderna looking so stronk tho | 22:47 |
| LjL | yeah | 22:47 |
| nixonix | .title https://twitter.com/EricTopol/status/1440696717020581903 didnt look much stronger in this one, only a little | 22:48 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "Does Moderna have an edge over Pfizer? https://www.nytimes.com/2021/09/22/health/covid-moderna-pfizer-vaccines.html @apoorva_nyc New data from ~148,000 breakthrough cases in [...] | 22:48 |
| Brainstorm | New from NPR: A CDC Panel Backs Booster Shots For Older Adults, A Step Toward Making Them Available: The advisory committee's recommendation expands on the FDA's authorization of Pfizer vaccine boosters for people 65 and up. Both regulatory moves will inform the U.S. plan to dispense extra doses. → https://is.gd/dqHNWB | 22:48 |
| imaginary | intervals def overlap a lot more in that | 22:51 |
| imaginary | hmm, delta fucks things up so much | 22:52 |
| nixonix | i want to see them adjusted for days since the second dose, age, etc. moderna has been stronger in pretty much every comparison (the above was perhaps the closest theyve had), but there might be things like when and where those different vaxes were administered | 22:52 |
| nixonix | and neutralizing ab comparison, after several months | 22:53 |
| LjL | <Brainstorm> New from Reddit (test): nCoV: With Time and Without Masks, COVID-19 Vaccines Wane in Protection → https://is.gd/174UBk | 22:59 |
| LjL | ↑ like, uh, yeah, i'm sure *with* masks, they magically won't wane *rolls eyes* | 23:00 |
| nixonix | it seems they adjusted for age, under or over 50, but needs to be tighter age groups (esp for comparing hospitalization rate), but not for days since the 2nd dose. small sample, different things could affect like regional differencies and timings of where and when pfizer or moderna was administered | 23:00 |
| rpifan | im starting to worry we wont get another wave of lockdowns | 23:01 |
| imaginary | nixonix: any idea if there's a precedent for delaying moderna's second dose? I know there is one for pfizer/biontech, just unsure about moderna | 23:01 |
| nixonix | moderna supposedly gives around double binding ab titers compared to pfizer (after 2nd dose), and likely neut abs something like that, although not confirmed. if ab titers are higher for moderna, it might benefit from longer interval even more than pfizer | 23:03 |
| nixonix | they have used long intervals for moderna in canada, uk, finland, some other european countries later, but not really good information available on modernas effectiveness with longer intervals | 23:04 |
| nixonix | my guess is, it doesnt affect that much on circulating titers, but it might affect a lot for b-cell maturation (longer interval) | 23:04 |
| nixonix | so possibly less severe cases after seveal months of waning, while waiting when they allow 3rd doses | 23:05 |
| nixonix | sure you could catch the rona before the 2nd, so depends on situation how long its good to wait. the same for the 3rd | 23:07 |
| imaginary | nixonix: really appreciate the info. definitely considering it as i'm not really too exposed atm (i get to work from home) | 23:08 |
| nixonix | there was that study on titers with long iterval, was it 16 weeks. really strong titers with long delay, i pasted it here couple days ago | 23:08 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In the meantime, we should give Pfizer boosters to Moderna/J&J who fit the high-risk criteria and collect the data! Likelihood of the happening........approaches zero. → https://is.gd/Ko00pQ | 23:09 |
| imaginary | nixonix: will try to find it through the logs | 23:10 |
| nixonix | im doing it already (: | 23:11 |
| nixonix | https://pbs.twimg.com/media/E_2l_zaVIAQM0Y-?format=jpg&name=4096x4096 | 23:12 |
| imaginary | this one maybe? https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3891065 | 23:12 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.09.17.21263532v1 | 23:12 |
| Brainstorm | nixonix: From www.medrxiv.org: Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a sixteen-week interval between doses | medRxiv | 23:12 |
| imaginary | ah nice | 23:12 |
| nixonix | prior the first dose of vaccine (V0), three weeks (V1, median [range]: 21 days [13–28 days]) and three months (V2, median [range]: 85 days [73–104 days]) after the first dose of vaccine and three weeks after the second vaccine injection (V3, median [range]: 21 days [13–42 days]) | 23:13 |
| LjL | i found it too! | 23:13 |
| LjL | now it's useless but because i found it, i will spam you with it anyway | 23:13 |
| LjL | [18:14:05] <nixonix> .title https://www.medrxiv.org/content/10.1101/2021.09.17.21263532v1 | 23:13 |
| LjL | [18:14:07] <Brainstorm> nixonix: From www.medrxiv.org: Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a sixteen-week interval between doses | medRxiv | 23:14 |
| LjL | [18:15:24] <nixonix> https://pbs.twimg.com/media/E_2l_zaVIAQM0Y-?format=jpg&name=4096x4096 | 23:14 |
| LjL | [18:16:15] <nixonix> prior the first dose of vaccine (V0), three weeks (V1, median [range]: 21 days [13–28 days]) and three months (V2, median [range]: 85 days [73–104 days]) after the first dose of vaccine and three weeks after the second vaccine injection (V3, median [range]: 21 days [13–42 days]) | 23:14 |
| LjL | [18:20:55] <nixonix> notice that naive (who dont have previous infection) vaccinated with 16 weeks interval beat both of those "hybrid immunity" groups (infection + one or 2 doses of vaccine) | 23:14 |
| nixonix | if you compare those titers vs 617.2 (delta) in the last pic V3, you see that with 16 week dose interval, pfizer was stronger with naive (non-infected) vaccinee and 2 doses, than those with previous infection and one or two doses of vax after that | 23:15 |
| nixonix | reminder: mention to turbo | 23:15 |
| nixonix | when he told about that video he saw yesterday (that those infected would have way stronger protection, based on that widely criticized israeli study) | 23:16 |
| LjL | %tell turbotech remind nixonix to mention the 16 week dose thing to you | 23:19 |
| Brainstorm | LjL, I'll pass TurboTech your message when they are around. | 23:19 |
| imaginary | i'm hoping to be able to delay for a month or so, hopefully i'll benefit from it | 23:21 |
| nixonix | its so damn transmissible, this current variant. i might get 2nd fast enough despite likely benefits from longer interval. theres always the 3rd one then | 23:23 |
| de-facto | well there probably is an optimum delay between primer and booster, depending on the target window for intended immune protection against that particular version of s-protein and/or the associated bredth of ab affinity (as function of pre-existing immune memory) | 23:25 |
| nixonix | days 5-10 after symptoms start (i think) are critical according to irene tosetti, like follow what oximeter says. in that study above they said that IC triggering happens around day 7 | 23:35 |
| nixonix | do they count the first symptomatic day as day 1 usually? (yeah, it varies when symptoms start, so those would be averages) | 23:35 |
| nixonix | .title https://twitter.com/itosettiMD_MBA/status/1421480214442426369 so start is day 1 or 0? | 23:37 |
| Brainstorm | nixonix: From twitter.com: Irene Tosetti (@itosettiMD_MBA): "Please get a pulse oximeter and check once a day especially from day 5 to 10th from onset of symptoms" | nitter | 23:37 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1440844638307323906 | 23:52 |
| Brainstorm | nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "Here is a hypothesis. As SARS COV 2 serially ages or "makes t cell memory" aka "differentiates" repertoires, we may see more peripheral tissue/ organ [...] | 23:52 |
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