libera/##covid-19/ Saturday, 2021-09-25

TurboTech.title https://www.frontiersin.org/articles/10.3389/fimmu.2018.02305/full00:03
BrainstormTurboTech: From www.frontiersin.org: Frontiers | Regulation of NLRP3 Inflammasome by Phosphorylation | Immunology00:03
TurboTechThat might put it all together00:03
BrainstormNew from Ars Technica: Science: As Florida punishes schools, study finds masks cut school COVID outbreaks 3.5X → https://is.gd/Bwa4q700:04
nixonix.title https://www.biorxiv.org/content/10.1101/2021.06.25.449893v4 about immunocomplexes that only some people are prone to develop, for unknown reasons, leading to severe condition00:06
Brainstormnixonix: From www.biorxiv.org: Circulating multimeric immune complexes drive immunopathology in COVID-19 | bioRxiv00:06
nixonix.title https://twitter.com/farid__jalali/status/1440876997182300169  content explained in the thread, and continues with stuff from his own studies00:07
Brainstormnixonix: From twitter.com: Farid Jalali MD (@farid__jalali): "Updated 🧵 on pathophysiology of COVID-19: We have had numerous descriptive studies, highlighting what we "see" as different in this disease. Examples include [...]00:07
TurboTechWhat is really funny this ER physician when I told him about NLRP3 he was like that is not that big of a deal in Covid.  I am like Bro you are clueless.00:17
TurboTechPRR's are pattern recognician receptors.00:18
BrainstormNew from r/WorldNews: worldnews: Indian doctors scale rockslides, invoke gods to vaccinate Himalayan villages → https://is.gd/wbmL6h00:26
TurboTechAbsolutely amazing.00:26
finely[m]https://www.abc.net.au/news/2021-09-25/low-mortality-rate-astrazeneca-covid-vaccine-clots-tts/10048940800:27
nixonixthere was a vaccine project, where they had some universal t-cell activating epitope added. not superantigen though. i forgot to look for more information when i read about it00:27
nixonixi was wondering how they have guts to recommend people az in australia. i guess they can treat it well, and people are warned about symptoms00:29
TurboTechMy friend is a retired immunologist and he passed on this tidbit.00:30
nixonixhow about damage if you dont die?00:30
TurboTechBTW, something that wasn’t disclosed is that the Moderna vaccine uses 100 ug mRNA, Pfizer only 30 ug.  Why it took the Israelis to see the drop in antibody titer in the Pfizer prep is incredible.  It’s like the U.S. was oblivious.00:31
TurboTechThat should be in qotes00:31
nixonixIn Australia, 11.3 million doses of the AstraZeneca vaccine — now called Vaxzevria — have been administered, with a total of 141 people developing a confirmed or probable case of TTS linked to the jab.00:31
nixonixOut of those 141 cases, eight people have died of the clots, or around 5.6 per cent. In the UK, the rate of dying from TTS was 17 per cent. However, research published in August showed in one study it was as high as 22 per cent.00:31
TurboTechSo here is the question.  Did these people already have endothelial dysfunction?00:32
TurboTechWe will never find out.00:32
TurboTechThis is a true sad state of affairs.00:32
nixonixand are all those above background? i suppose they cant say for sure, if they are similar, or its really extremely rare without those vaccines00:33
TurboTechIt is like they refuse to look at potential common factors.00:33
nixonixbut those dose sizes have been public all the time00:33
TurboTechThey seem to only want to treat the symptoms.00:33
TurboTechI know we are talking about two different things.00:34
nixonixi dont think the mechanism is confirmed. there has been several suggested mechanisms00:34
TurboTechUnderstood, but is there a potential common factor in all the mechanisms?00:35
nixonixmedia just stopped at some point, and people think, well that was the cause (and whatever they meant)00:35
nixonixi havent read that something like that was found00:35
TurboTechWe keep hearing about all these pre conditions00:35
TurboTechBut are there links in all these previous comorbids?00:35
nixonixprob not, because i havent read00:36
TurboTechIt is like fighting a fire.  You have to remove one of three things.00:36
nixonixit seems jnj has much less similar problems00:37
TurboTechWe have the Virus, then the Bodies response to the virus.00:37
nixonixand why is that (if true, and not just because its less used, and usa dont have proper national medical recods)00:37
nixonix.title https://news.yahoo.com/german-scientist-believes-hes-found-204625780.html  this could explain the reason (while not necessarily the reason, anyway)00:38
Brainstormnixonix: From news.yahoo.com: German scientist believes he's found solution to blood clots linked to AstraZeneca, Johnson & Johnson COVID-19 vaccines00:38
nixonixif i recall, they were studying the problem together, maybe with that german researcher, but idk00:39
nixonix.title https://khn.org/news/article/covid-autoimmune-virus-rogue-antibodies-cytokine-storm-severe-disease/00:39
Brainstormnixonix: From khn.org: Coronavirus Deranges the Immune System in Complex and Deadly Ways | Kaiser Health News00:39
BrainstormUpdates for Mauritius: +298 cases (now 15161), +11 deaths (now 71) since 2 days ago00:41
TurboTechWell, I can not for the life of me understand that people less than 30 are coming in at the end of summer with vitamin d levels clinically deficient while having positive covid tests.00:41
nixonixcheck out this eric feigl-dings twitter thread:00:42
nixonix.title https://twitter.com/DrEricDing/status/144141454090255156100:43
Brainstormnixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "8) “In recent weeks, some anti-vaccine @Facebook groups and conspiracy theory influencers on the encrypted messaging app Telegram have offered instructions on how to [...]00:43
Brainstormnixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "8) “In recent weeks, some anti-vaccine @Facebook groups and conspiracy theory influencers on the encrypted messaging app Telegram have offered instructions on how to [...]00:43
nixonix"Many users in the Ivermectin groups push conspiracy theories about how Food and Drug Administration-recommended treatments frequently used by doctors and nurses in hospitals are secretly killing patients, and some have implied doctors and nurses are killing patients on purpose so they can receive government payouts.00:47
nixonixConspiracy theorists have pushed the idea that the antiviral drug remdesivir and the use of ventilators are “drowning” unvaccinated Covid patients. In reality, unvaccinated patients are dying of the debilitating effects Covid has on the lungs.00:47
nixonix.title https://www.nbcnews.com/tech/tech-news/vigilante-treatments-anti-vaccine-groups-push-people-leave-icus-rcna2233  tosetti was right, its a death cult00:48
Brainstormnixonix: From www.nbcnews.com: 'Vigilante treatments': Anti-vaccine groups push people to leave ICUs00:48
finely[m]<nixonix> "i was wondering how they have..." <- Mostly given to older people where the tts risk is much lower and the vivid risk much higher. Younger people get mRNA vaccines.00:50
nixonixthey were actively trying to get younger people to get AZ in australia, just a few weeks ago. maybe not anymore, when they have got more mrna vaccines now00:51
nixonixat least in nsw, where cases have been high00:51
finely[m]<nixonix> "and are all those above backgrou..." <- All determined to be AZ caused by pathologists on autopsy, I think.00:52
TurboTechWhat is really interesting.  I wonder if we can look at RDW which is a part of a calculation of the Complete Blood count and look at potential prognosticator of death.00:53
qkall[m]Just popping in to say I enjoy the conversation...and find it super funny how some dude was upset a couple days ago to see folks chatting here.00:53
nixonix.title https://www.dailymail.co.uk/tvshowbiz/article-10023399/Shane-Warne-reveals-ventilator-prevent-long-Covid.html  tell me whats this shit00:53
Brainstormnixonix: From www.dailymail.co.uk: Shane Warne reveals he was on a ventilator to prevent long Covid | Daily Mail Online00:53
qkall[m]❣️00:53
TurboTechRDW (Red Cell Distribuition width) is already a prognosticator of cause mortality.00:54
nixonixwho was upset, and why? somebody complaned on another channel?00:54
nixonixshould be just ocassional links from bot here?00:54
nixonixguess what happened... i came back!00:54
qkall[m]No it was here they were like00:55
TurboTechOh my gosh.  Look at this.  I just looked this up for the first time.  .title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056748/00:55
qkall[m]"why are you talking"00:55
nixonix(well i used to chat on the other channel more last year)00:55
qkall[m]Basically00:55
TurboTech.title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056748/00:55
BrainstormTurboTech: From www.ncbi.nlm.nih.gov: Validation of red cell distribution width as a COVID-19 severity screening tool - PMC00:55
qkall[m]It was super weird00:55
finely[m]nixonix: Yep, desperately trying to avoid overwhelming the hospitals after the data government totally screwed up an outbreak.00:55
nixonixljl why are they complaining about me?00:56
finely[m]*state government00:56
qkall[m]<undefined_bob> "this isnt even a real chat..." <- Here it is00:57
nixonixit used to be early in the epidemic, most of the chat was on the other channel, and here it was more like links and stuff. but idk how was it while i was awol. generally much less chat i think, americans got the vaccines, everything returned back like it was...00:58
qkall[m]Maybe it's my nindo or some shit00:59
qkall[m]But I think more conversation in anything is an answer00:59
LjLnixonix: I guess sometimes you monologue a bit, but I have no idea right now who's complaining and why... Looks like qkall[m] is referring to something from a while ago?01:00
qkall[m]Oh yeah sorry I love conversation01:01
qkall[m]Sorry not implying you fam01:01
jbwncsternixonix: it never went back to normal01:01
qkall[m]nixonix: 🤜🤛01:01
jbwncsterIn usa01:01
jbwncsterPeople are refusing to get the vaccine and wear a mask01:01
jbwncsterLike daily01:01
TurboTechGuys, I need to get going.  I work tonight and want to grab a 3-4 hour nap before work.01:02
qkall[m]Preach jbwncster01:02
TurboTechTalk to all soon.01:02
TurboTechBe well all.01:02
qkall[m]I argue with folks daily.......01:02
jbwncsterAnd then there are retired people who want kids to not have masks at schools and they don’t have a kid in the school system01:02
jbwncsterPeople need to stay in their lane01:02
qkall[m]Oh God one second relevant pic01:03
jbwncsterAlso I keep telling people I’ll see them at the funeral home since they don’t take proper precautions01:03
LjL-Matrixjbwncster: but their know what's best for their grandkids! (Unlike, of course, their stupid in-laws)01:03
nixonixgenerally its hard to find chat or forum discussion where people know much, have read studies or will read if linked. there is some chat in reddit, then scattered around in twitter01:04
nixonixdespite that "Out of the world's approximately 7.8 billion inhabitants, 1.35 billion speak English. The majority aren't native English speakers01:06
* qkall[m] uploaded an image: (311KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/tCVEXimbDfkZJVyqHKFhfbNz/IMG_20210924_190521.jpg >01:07
LjL%title https://twitter.com/fitterhappierAJ/status/1441459526247538688 gee Leonardi really likes to hope for the worst01:07
nixonixsoccer, celebrities etc are just more interesting to almost all of them. this is the smallest niche topic (at deeper lever than arguing on restrictions and stuff)01:07
BrainstormLjL: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "I still disagree with Antia and colleagues. Notably, their paper did not consider any salient features of cov2 that tie fitness with virulence" | 42l - [...]01:08
LjLqkall[m], if i had a garden i'd probably find some time to decorate it too01:08
qkall[m]I should mention the signs change pretty regularly01:08
qkall[m]It's almost impressive01:09
qkall[m]....almost01:09
LjLqkall[m], it should come with instructions though. how am i supposed to stand for the flag and kneel for the cross *at the same time*, since both are present?01:10
qkall[m]I think the default is 'whats trump saying about this' sadly01:11
jbwncsterI kind of wish each state had their own border control like in Russia01:11
jbwncsterBut then I don’t cause we don’t need that01:11
qkall[m]Literally people thought it was going to be president again like last weej01:11
LjLew01:11
nixonix.title https://twitter.com/fitterhappierAJ/status/1437785721381822473  (:01:12
qkall[m]We're beyond help I think01:12
jbwncster But I wish states like Hawaii could shut all the airports down01:12
Brainstormnixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "i've warned adequately, except for the time i was disallowed from going on tv." | nitter01:12
jbwncsterUntil covid is over01:12
jbwncsterMinus cargo01:12
LjLjbwncster, i don't think it's that way anymore in russia either... there are some restricted areas but it's not a blanket thing about states (don't quote me though, could be wrong). in china and belarus on the other hand, i'm aware those are places where you need official permission to move to a different residence01:12
jbwncsterLjL: Russians have 2 passports01:13
jbwncsterAn internal one and an external one01:13
pwr22That person saying this room was just news before libera and wasn't bridged to matrix....01:14
pwr22Have you given the wrong channel / room 😂?01:14
qkall[m]Right01:14
qkall[m]I tried to talk to them and they were like no you're new here01:15
qkall[m]And I was like I mean... Maybe a year new?01:15
pwr22jbwncster: The UK is is Islands for the most part and we haven't bothered to use that advantage either 😭01:15
jbwncsterThey should01:15
jbwncsterThey did it once01:15
jbwncsterLast year during the holidays01:16
LjLjbwncster, uhm, but how is the internal passport effectively different from a mandatory ID card (as in many EU countries for instance) except for being bulkier? https://en.wikipedia.org/wiki/Internal_passport_of_Russia doesn't mention them being necessary for crossing state lines in the modern day, but i'll read further01:16
pwr22qkall[m]: Yeah, I've been here a while too and there's always been talking01:16
LjLalso towards the end it says they're slated to be replaced with ID cards, although it's been repeatedly postponed01:16
qkall[m]aye01:17
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Infection control involves cutting off transmission even if intermediates aren't intubatedHCW treating the infirm mustn't pass on infection to their patients, which the vaccines can not wholly preventTherefore it is informed negligence and endangerment to neglect N95 necessity [... want %more?] → https://is.gd/Cpu3u701:18
nixonix.title https://twitter.com/DrEricDing/status/1440761982882250757  (its not bojo's dystophy, i think. and happening in many places and countries, i read from the thread. crazy)01:28
Brainstormnixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "📌Under @BorisJohnson’s dystopian rules— you are forced to **remove your high grade FFP3 (N95 grade) respirator mask**, and instead wear a flimsy surgical mask. We [...]01:28
nixonix*dystopia01:29
BrainstormUpdates for Ecuador: +274 cases (now 507294), +16 deaths (now 32682), +9493 tests (now 1.8 million) since 3 days ago01:30
LjLnixonix, my parents have been required to wear a surgical mask (not an FFP2) at various medical places. but usually they were allowed to just put it on top of their FFP201:41
de-factolol whut?01:42
de-factowhy would they force people do downgrade their certified masks without valves?01:43
de-factothat makes exactly zero or less sense01:43
LjLhere, ranted about it some https://twitter.com/BrainstormBot/status/144154897234305024001:44
nixonixdamn, you have a lot of followers. or are they bots too, hmm?01:46
nixonixbtw are there original twitter celebrities? known just form twitter and millions of followers01:47
LjLnixonix, they are not bots (mostly), but that's because my bot gives them earthquake warnings01:48
LjLthey aren't really there to follow my covid rants :P01:48
LjLi used to have my own "ljl" account but then one day i got mad at the internet and deleted a bunch of social-type accounts01:48
nixonixdo another rona-only account to test how many followers this topic will gain01:49
nixonixthose big rona names in twitter like erics are well known from other media. they have 5-600k01:49
LjLi don't really post a lot of things about covid01:50
LjLand i'm not sure i want to get into that "business", i am already angry enough :P01:50
LjLi'll just sometimes grumble under Brainstorm's disguise01:50
* Brainstorm grumbles01:50
nixonixcelebrities and soccer. and thats it for most01:53
nixonixhere celebrities and hockey, though01:53
LjLwell, you can rest assure i tweet about neither celebrities nor soccer01:53
LjLas i couldn't give less of a damn about either01:54
nixonixthey are almost dead already, other topics of interests. first the little there still are die, then hockey too, and it will be only celebrities and soccer. evolution of human kind. computer games yeah, but they are celebrity and soccer games01:56
LjLi think people are interested in a lot of things02:02
LjLi see the future as bleak, but not for this particular reason02:02
BrainstormUpdates for St. Martin: +81 cases (now 3727), +8 deaths (now 55) since 5 days ago — St. Barthelemy: +1 deaths (now 3) since 3 days ago02:08
nixonixkariko and weissman got lasker award. "Lasker Award has gained a reputation for identifying future winners of the Nobel Prize. Eighty-six Lasker laureates have received the Nobel Prize, including 32 in the last two decades02:12
nixonix.title https://twitter.com/R_H_Ebright/status/144148365299557990702:31
Brainstormnixonix: From twitter.com: Richard H. Ebright (@R_H_Ebright): "This is correct. Neither face protection, nor PAPRs, nor even N95s are mandated under BSL-3. Decisions on whether to use face protection and whether to use [...]02:31
BrainstormUpdates for Benin: +1508 cases (now 22958), +8 deaths (now 154) since 5 days ago — United Kingdom: +35683 cases (now 7.6 million), +188 deaths (now 136070) since 23 hours ago — Rwanda: +55 cases (now 96392), +2 deaths (now 1235), +22333 tests (now 2.7 million) since a day ago02:33
BrainstormNew from COVID tweets: Prof Francois Balloux (@BallouxFrancois): One corollary in terms of prediction of future variant emergence is that if it were correct that SARSCoV2 has largely explored its fitness landscape for now, the dominant lineages in circulation in the near future will most likely be descendants of the Delta variant.11/ → https://is.gd/QYIMoD02:33
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): A good milestone achieved today.If only we could get to 70-75% of total population fully vaccinated; a dozen countries have already done that twitter.com/cyrusshahpar46… pic.twitter.com/zg3g31Zc6E → https://is.gd/euZT0003:05
BrainstormUpdates for Bermuda: +182 cases (now 4982), +7 deaths (now 52), +4982 tests (now 531049) since a day ago — Channel Islands: +39 cases (now 11466), +6958 tests (now 911340) since a day ago03:35
BrainstormNew from r/WorldNews: worldnews: Bizarre legal theory making anti-vaccine movement more extreme, experts warn - Opposition to public health measures vaults Freemen-on-the-land ideology into public eye → https://is.gd/4cG12W03:59
BrainstormNew from r/WorldNews: worldnews: NBA denies Canadian Andrew Wiggins of religious exemption to skip COVID-19 vaccine - Local guidelines now make Warriors forward ineligible to play home games → https://is.gd/UVmH6W04:32
BrainstormUpdates for United Kingdom: +35695 cases (now 7.6 million), +187 deaths (now 136115) since 23 hours ago — Canada: +5381 cases (now 1.6 million), +46 deaths (now 27636) since 23 hours ago — Australia: +1828 cases (now 94844), +12 deaths (now 1212), +194245 tests (now 36.9 million) since 23 hours ago04:37
BrainstormNew from r/Science: science: Study finds lower rates of hospital-acquired COVID-19 in wards with vaccinated healthcare workers → https://is.gd/w4pS6A04:43
BrainstormNew from The Atlantic: The Lab-Leak Debate Just Got Even Messier: As the pandemic drags on into a bleak and indeterminate future, so does the question of its origins. The consensus view from 2020, that SARS-CoV-2 emerged naturally , through a jump from bats to humans (maybe with another animal between) persists unchanged. But suspicions that the [... want %more?] → https://is.gd/LKlvsi04:53
BrainstormNew from Virology.ws: Trial By Error: Good Long Covid Coverage from Atlantic; Skeptical Coverage from New Yorker and Others: By David Tuller, DrPH On September 1st, The Atlantic published another excellent piece by Ed Yong—“Long-haulers are fighting for their future.” In exploring how this population has confronted widespread misunderstanding in [... want %more?] → https://is.gd/PMJ9Mv05:04
BrainstormNew from This Week In Virology: TWiV 808: Clinical update #81 with Dr. Daniel Griffin: In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens. → https://is.gd/rHQyhB06:19
BrainstormUpdates for Belgium: +2200 cases (now 1.2 million), +11 deaths (now 25554), +51625 tests (now 19.8 million) since 23 hours ago06:29
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Your argument is bunk. Medical masks were just as 'intolerable' as PAPRs and N95s.I am starting to think you are getting into dishonesty territory. twitter.com/AntibioticDoc/… pic.twitter.com/ksaF9nTFoG → https://is.gd/wPUcwP06:30
BrainstormNew from COVID tweets: Josiah Grindrod (@JT_Grindrod): @fitterhappierAJ I live where there's constant wildfires and the AQI is frequently >200. I have no problems wearing an N95 all day. Do people not value their health over mild discomfort? → https://is.gd/PJwr7r06:40
BrainstormNew from The Indian Express (Health): Fashion: Prada strips dresses back, foulard inspires Versace in Milan → https://is.gd/GIe2Z107:02
BrainstormUpdates for Sarawak, Malaysia: +2825 cases (now 193434) since a day ago — Selangor, Malaysia: +2244 cases (now 668253) since a day ago — Pulau Pinang, Malaysia: +1231 cases (now 124878) since a day ago — Perak, Malaysia: +1144 cases (now 96830) since a day ago07:37
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): To compound possible evidence of obfuscation and omission, the link in the tweet was broken. As a barrier/deterrent to clicks? let's see what image is from the valid linkLook- it is the table showing medical masks and n95s/paprs equivalent!  jamanetwork.com/journals/jama/… → https://is.gd/DfjWqS07:44
BrainstormUpdates for India: +29616 cases (now 33.6 million), +584 deaths (now 446572) since 22 hours ago08:40
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): A lot of 10¢ virologists raked me over coals for claiming SARS viruses were humanity's natural enemies, in symbiosis with batsMaybe bc they knew of proposals to insert furin cleavage sites into bat SARS viruses to make them worse, hahaTo them this seems like a good idea 😱 [... want %more?] → https://is.gd/Uk7YOT08:59
BrainstormNew from COVID tweets: DecodingTrolls (@DecodingTrolls): @fitterhappierAJ @sgeekfemale @flowermusickids Wow. So is it fair to say "Living With Covid" is grand for 🦇, but it's 🦇s to say that humans can Live With Covid (cos our immune system goes 🦇-s**t Crazy as soon as it encounters either a 🦇 or one of its corona-viruses)?! Do GBD'istas [... want %more?] → https://is.gd/9ATB7d09:09
BrainstormUpdates for New Caledonia: +154 cases (now 5959), +10 deaths (now 72) since a day ago09:29
BrainstormNew from The Indian Express: World: Covid, climate, security, China: Highlights from Quad leaders’ summit → https://is.gd/hz7IV710:23
BrainstormNew from r/WorldNews: worldnews: Return to school has caused a surge in covid-19 cases in under-vaccinated counties → https://is.gd/mmDff911:06
BrainstormUpdates for Slovakia: +1039 cases (now 407799), +2 deaths (now 12596), +10449 tests (now 3.6 million) since a day ago — Germany: +11932 cases (now 4.2 million) since 23 hours ago11:34
sdfgsdfgtwo thirds of hospitalised patients in uk are double vaxed wow11:58
sdfgsdfglooks at this news from 16 hours ago11:59
sdfgsdfghttps://www.bbc.com/news/uk-wales-5868020411:59
BrainstormUpdates for Russia: +22041 cases (now 7.4 million), +1758 deaths (now 203095), +513976 tests (now 189.3 million) since a day ago12:11
BrainstormNew from Reddit (test): nCoV: Singapore restricts social gatherings as COVID-19 spike worsens | 24SEP21 → https://is.gd/T1602W12:30
de-facto[m]It depends on vaccination prevalence, imagine if all people are vaccinated 100% of hospitalized patients are breakthroughs because there are no unvaccinated12:40
de-facto[m]But hospitalization attack rate among breakthroughs will be lowered by one order of magnitude or such12:42
BrainstormNew from PubMed: Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, is one of the biggest threats to public health. However, the dynamic of SARS-CoV-2 infection remains poorly understood. [... want %more?] → https://is.gd/fX8gKU13:56
BrainstormUpdates for Romania: +7676 cases (now 1.2 million), +121 deaths (now 36230), +67364 tests (now 12.6 million) since 23 hours ago — Croatia: +1293 cases (now 399054), +14 deaths (now 8580), +19983 tests (now 2.8 million) since a day ago — Gibraltar: +8 cases (now 5510), +853 tests (now 357343) since 21 hours ago14:03
de-facto.title https://www.sciencedirect.com/science/article/pii/S221334372101194514:05
Brainstormde-facto: From www.sciencedirect.com: Experimental and CFD evaluation of ozone efficacy against coronavirus and enteric virus contamination on public transport surfaces - ScienceDirect14:05
de-facto.title https://www.science.org/doi/10.1126/science.abh231514:07
Brainstormde-facto: From www.science.org: Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study14:08
BrainstormUpdates for Brunei: +4 deaths (now 37), +4487 tests (now 330478) since a day ago — Faroe Is.: +17 cases (now 1115), +3000 tests (now 426000) since 22 hours ago15:05
BrainstormUpdates for Nepal: +790 cases (now 790662), +6 deaths (now 11087), +7050 tests (now 4.2 million) since a day ago15:30
BrainstormNew from r/Coronavirus: Coronavirus: New York Hospitals Face Possible Mass Firings as Workers Spurn Vaccines → https://is.gd/gdlsWx15:33
BrainstormNew from r/Coronavirus: Coronavirus: Garth Brooks playing dive bars rather than stadiums because 'dive bars are vaccinated → https://is.gd/h0mjLD15:43
BrainstormUpdates for Norway: +649 cases (now 186349), +17584 tests (now 7.8 million) since 23 hours ago — Qatar: +108 cases (now 236231), +5005 tests (now 2.6 million) since a day ago — Namibia: +89 cases (now 127160), +2 deaths (now 3490), +4877 tests (now 695621) since a day ago — Saudi Arabia: +11 cases (now 546803), +2 deaths (now 8686), +32549 tests (now 28.7 million) since a day ago16:32
BrainstormNew from COVID tweets: Tom Wenseleers (@TWenseleers): Risk for myocarditis after vaccination with mRNA vaccines is 1 in 25,000. The risk for 12-17 yr olds to experience myocarditis following a Covid infection is ca. 10x higher, 1 in 2,200. newscientist.com/article/mg2513… twitter.com/bachyns/status… → https://is.gd/dx27ec16:38
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): And yes, accidental release of a virus is a new pandemic as it was in 1977 twitter.com/R_H_Ebright/st… pic.twitter.com/i3lNtQaaod → https://is.gd/X3moGf16:59
BrainstormUpdates for Germany: +10327 cases (now 4.2 million) since 23 hours ago17:09
BrainstormNew from Politico: Coronavirus: Dutch minister fired over coronavirus passport criticism → https://is.gd/tkzLd217:10
BrainstormNew from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Is the freeze and later re-release of a naturally emergent pandemic virus (1949-1950) an entirely new pandemic (1977)? → https://is.gd/kdL12317:31
BrainstormUpdates for Chile: +747 cases (now 1.7 million), +9 deaths (now 37432), +143360 tests (now 21.5 million) since 23 hours ago17:34
BrainstormNew from COVID tweets: Josiah Grindrod (@JT_Grindrod): @fitterhappierAJ LolSo if a foreign state released smallpox back out into the world, that wouldn't be a new pandemic? Do these people here listen to themselves? → https://is.gd/86LBHu17:42
BrainstormNew from COVID tweets: Tom Wenseleers (@TWenseleers): Percentage of confirmed Covid infections that were acquired in hospital decreased from 14% to 4% in England over the last year. Glad hospitals have become a lot safer over the course of the pandemic. twitter.com/LawtonTri/stat… → https://is.gd/63k5QM17:53
BrainstormUpdates for United Kingdom: +41571 cases (now 7.6 million) since 23 hours ago17:59
BrainstormNew from Reddit (test): CoronavirusUK: Saturday 25 September 2021 Update → https://is.gd/bxl37418:03
de-facto.title https://www.rki.de/DE/Content/Kommissionen/STIKO/Empfehlungen/PM_2021-09-24.html18:24
Brainstormde-facto: From www.rki.de: RKI - Empfehlungen der STIKO - Pressemitteilung der STIKO zu Immundefizienz und Koadministration (24.9.2021)18:24
de-facto.title https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2021/39/Art_02.html18:24
Brainstormde-facto: From www.rki.de: RKI - Archiv 2021 - STIKO-Empfehlung zur COVID-19-Impfung bei Personen mit Immundefizienz und die dazugehörige wissenschaftliche Begründung18:24
BrainstormUpdates for Bangladesh: +818 cases (now 1.6 million), +25 deaths (now 27393) since a day ago — Jordan: +438 cases (now 818796), +16 deaths (now 10669), +16587 tests (now 9.9 million) since 22 hours ago18:36
BrainstormNew from r/WorldNews: worldnews: "If we can find the will to send people to the moon and solve male baldness.. we can solve simple problems like letting our people eat at affordable prices". Impassioned Barbados prime minister Mia Motley sought to spur meaningful global action on crises like climate, vaccines, poverty and education → https://is.gd/6RncWy18:47
BrainstormNew from The Indian Express (Health): Life-style: Ditched the dye during Covid? Maybe stay gray → https://is.gd/U92H0m19:08
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): A 3rd dose (aka booster) was always envisioned to be necessary for most covid vaccines (as w/ many other vaccines); it was only a matter of when. @bgzimmer on origin of the word "booster""Those in favor of giving out extra doses are 'booster boosters.'"wsj.com/articles/boost… pic.twitter.com/iNy1xC72ZF → https://is.gd/vYMztN19:19
BrainstormUpdates for Italy: +3519 cases (now 4.7 million), +50 deaths (now 130653) since a day ago19:39
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): The waning of Pfizer and Moderna vaccine protection vs *symptomatic infections* over time in all age groups, slide presented at ACIP @CDCgov meeting by Sara Oliver MD cdc.gov/vaccines/acip/…(this was the primary endpoint for the pivotal trials to approve these vaccines) pic.twitter.com/D7YtFHC7dR → https://is.gd/i8HlQX19:40
nixonixwho knows something about common colds, flu, sniffles etc? id like to find information on kinetics of "normal" respiratory viruses immune responses, on what day happens what - interferons, nk cells, symptoms, different antibody types, viral loads, cd8 and cd4 activation etc. meaning all or most of them together, not just some IgM and IgG curves19:55
nixonixseem to be hard to find19:55
nixonixalso are those considered primary infections, when most of time whe have met the same viruses before. if not, why there are curves everywhere where they have primary and secondary infections, if almost every infection (excluding as a young child) is not the first encounter19:58
nixonixmeaning, considered as a first, if the immunity has waned enough, so that it doesnt matter much...19:59
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Red=Delta (Green=pre-Delta)It's still early into the period of waning, w/ frequency of exposures increasing over time.Recall the UK (and other countries) decision to provide 3rd shots irrespective of vaccine to all age 50+ is at odds with FDA/CDC (Pfizer only, age 65+) → https://is.gd/os318A20:02
nixonixi have some rough ideas, correct me if im off: type I interferons very fast, when viral loads are still low, like hours. (nk cell activation and proliferation maybe during the first few days?), symptoms maybe 3-5 days on average since exposure, IgM perhaps 5-6 days?, IgG maybe 8 days or something?20:07
nixonixhow about mucosal IgA? and all of them a few days faster, if previous immunity still good20:08
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): Meanwhile we have left the people who got a J&J vaccine stranded with comparatively very low antibody levels 2-6 weeks after dosing, while we've learned such levels are tied to protectioncdc.gov/mmwr/volumes/7…I think that's now ill-considered. pic.twitter.com/ZphClGpPTq → https://is.gd/VcmmjO20:13
nixonixref to that topol's tweet - how about jnj vs severe, is it waning slower than with mrna vaxes? whats the best information on breakthrough hospitalizations pfizer vs moderna vs jnj (and az)?20:19
nixonixok, doesnt look too good for jnj: "Among U.S. adults without immunocompromising conditions, vaccine effectiveness against COVID-19 hospitalization during March 11–August 15, 2021, was higher for the Moderna vaccine (93%) than the Pfizer-BioNTech vaccine (88%) and the Janssen vaccine (71%)20:20
nixonixwhat was it for jnj vs hospitalizations when not waned too much? over 90%20:22
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): It's as if the denialists of waning vs symptomatic infections think this issue will just go away over time, despite this endpoint being an accepted surrogate for hospitalizations. Meanwhile this is putting those not covered by current criteria, but at risk, for #LongCovid, too. → https://is.gd/lXphPa20:23
nixonixso eric, you are saying its mostly about antibodies, not about t-cells?20:25
BrainstormNew from COVID tweets: Eric Topol (@EricTopol): The transition for COVID-19 from epidemic to endemic phase. Excellent, by Rustom Antia and Elizabeth Halloran @EmoryUniversity @fredhutch cell.com/immunity/fullt… @ImmunityCP pic.twitter.com/874dbBuwiJ → https://is.gd/UXtwYE20:44
nixonix"Qualitatively, immunity to hCoVs in adults gives rise to transient protection from infection (indicating that high hCoV IES reinfections after infection that wanes over a few years)."21:03
nixonixreally? a few years? (IEs aka suspectibility, protection against infection, for common cold ronas) When its actually months or within a year most of time...21:04
nixonix.title https://www.cell.com/immunity/fulltext/S1074-7613(21)00404-0  this one, in topol's tweet21:05
Brainstormnixonix: From www.cell.com: Transition to endemicity: Understanding COVID-19: Immunity21:05
nixonixthey seem to be claiming that rona will become milder as endemic, and claim that it happened with OC43, that they claim was behind russian flu. afaik it has never been proved it was OC4321:07
nixonixlots of "we expect..."21:10
nixonixshould have been "our guess is..."21:10
nixonix"Collectively, o these studies indicate that shortly after infection, individuals are refractory to reinfection, but this protection wanes with time, and individuals can get reinfected with circulating hCoVs every few years."21:26
nixonixwhen it should be "every few years". no wonder, why they are so lost. but strange that the cell published it...21:26
nixonixwhen it should be "every few *months". no wonder, why they are so lost. but strange that the cell published it...21:27
BrainstormUpdates for Canada: +49 deaths (now 27651) since 22 hours ago21:31
nixonix.title https://twitter.com/fitterhappierAJ/status/1441774871378219016  i was suspecting something like this, another day21:44
Brainstormnixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "Too many virologists also pretend to know immunology and get far too defensive when called out " | nitter21:44
BrainstormNew from Reddit (test): nCoV: Louisville Zoo vaccinating animals for COVID-19 → https://is.gd/9Q9bhx21:48
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: After Texas A&M student died from COVID-19, students and faculty rally for more safety precautions → https://is.gd/D3wqiL21:59
p0indexter09717621ncc171622:05
BrainstormNew from r/WorldNews: worldnews: Preliminary research finds that even mild cases of COVID-19 leave a mark on the brain – but it's not yet clear how long it lasts → https://is.gd/QnyDQP22:09
nixonix.title https://www.news-medical.net/news/20200929/Computer-model-unravels-mystery-behind-severe-inflammation-in-people-with-COVID-19.aspx  behind MIS-C and (some of) severe symptoms, but doesnt affect to everybody? or maybe it does, when systemic infection, but most people clear it anyway?22:15
Brainstormnixonix: From www.news-medical.net: Computer model unravels mystery behind severe inflammation in people with COVID-1922:15
nixonixif it doesnt, some genetic suspectibility in some?22:15
nixonix.title https://theconversation.com/preliminary-research-finds-that-even-mild-cases-of-covid-19-leave-a-mark-on-the-brain-but-its-not-yet-clear-how-long-it-lasts-166145  since yahoo sucks, here's the same article (that reddit link)22:17
Brainstormnixonix: From theconversation.com: Preliminary research finds that even mild cases of COVID-19 leave a mark on the brain – but it's not yet clear how long it lasts22:17
BrainstormNew from r/WorldNews: worldnews: Decision to end all COVID-19 measures was a mistake, says provincial infectious disease doctor → https://is.gd/wNqyUM22:20
nixonix"Interestingly, when the researchers separated the individuals who had severe enough illness to require hospitalization, the results were the same as for those who had experienced milder COVID-1922:23
nixonixgood news of the day: if you get it bad, the loss of brain mass isnt necessarily worse22:24
de-factowhat are the long term implications of that? what are the relations to diseases like Alzheimers or MS?22:26
de-facto.title https://academic.oup.com/biomedgerontology/article/75/11/2231/584345422:27
Brainstormde-facto: From academic.oup.com: APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort | The Journals of Gerontology: Series A | Oxford Academic22:27
de-facto.title https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340057/22:30
Brainstormde-facto: From www.ncbi.nlm.nih.gov: Multiple sclerosis following SARS-CoV-2 infection - PMC22:30
BrainstormUpdates for Germany: +9019 cases (now 4.2 million) since 23 hours ago22:33
nixonixv3 out from that biobank study (link is in that article above). btw, i first overlooked it, because it confused me with the finding, that thalamus was significantly smaller on those that had rona infection, but then those individuals had it almost as small before the infection22:39
nixonixthanks to ljl i then had another look, that it was not the same with some other regions on many other regions (was it on right side)22:41
nixonix.title anyways, it looks like its end of good news today, because22:42
Brainstormnixonix, the command line provided is invalid22:42
nixonix.title https://www.nature.com/articles/d41586-021-02596-222:42
Brainstormnixonix: From www.nature.com: Closest known relatives of virus behind COVID-19 found in Laos22:42
nixonix"Particularly concerning is that the new viruses contain receptor binding domains that are almost identical to that of SARS-CoV-2, and can therefore infect human cells22:42
nixonix"one section in BANAL-103 and BANAL-52 could have shared an ancestor with sections of SARS-CoV-2 less than a decade ago22:43
nixonixbut its not about one section. sure, due to recombination it might be, but more likely not22:43
nixonix"RaTG13, which was found in bats in Yunnan5. It is 96.1% identical to SARS-CoV-2 overall and the two viruses probably shared a common ancestor 40–70 years ago6. BANAL-52 is 96.8% identical to SARS-CoV-2, says Eloit22:43
nixonixbut there's no sample proving RaTG13 exists in reality. other than chinese and daszak's word. im not sure who i trust more...22:44
nixonixdaszak says, the sample was destoryed22:45
nixonixthat pangolin virus had more similar RBD, but otherwise not close. this seems to have more similar RBD and otherwise closer to claimed ratg13. not really a missing link imo22:46
nixonixno furin site on those, so probably not too dangerous. but shows that more spillovers are around the corner22:48
de-facto.title https://www.researchsquare.com/article/rs-871965/v122:49
Brainstormde-facto: From www.researchsquare.com: Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula | Research Square22:49
nixonixmaybe they have lower mortality in australia, compared to uk, from az induced TTS, because in australia they identify larger share of milder cases than in uk, where they have always been very dismissive about risks of az23:03
nixonixi just read an article where the author wrote about the problem without ever mentioning the particular vaccine. just "vaccines"23:04
nixonix.title https://www.news-medical.net/news/20210921/Could-monitoring-headaches-after-COVID-19-vaccination-help-identify-rare-cases-of-cerebral-venous-thrombosis.aspx23:08
Brainstormnixonix: From www.news-medical.net: Could monitoring headaches after COVID-19 vaccination help identify rare cases of cerebral venous thrombosis?23:08
nixonix.title https://twitter.com/DGBassani/status/1420133054274748419   the goal...23:20
Brainstormnixonix: From twitter.com: Diego Bassani, PhD 🏠😷 💉 💉 (@DGBassani): "Some places around the globe have experienced a loosely defined state of endemicity at some point during this pandemic, mostly fleeting, but some for bouts of [...]23:20
BrainstormNew from r/WorldNews: worldnews: A daily pill to treat Covid could be just months away, scientists say → https://is.gd/lsskP923:23
nixonix"Any given day, interns make 100 calls to newly Covid-positive people in the Seattle area — and most say no.23:30
nixonix“Just generally speaking, there’s a lot of mistrust about the scientific process,” Duke said. “And some of the people are saying kind of nasty things to the interns.”23:31
de-facto.title https://www.science.org/doi/10.1126/science.abh2315 <-- imho really important paper about spike mutations and antibody affinity23:43
Brainstormde-facto: From www.science.org: Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study23:43
de-factonixonix,  ^^23:44
de-facto"SARS-CoV-2 will continue to evolve. By understanding antibody footprints and the distinct ways by which antibodies target Spike, we may deduce optimal combinations of mAbs to prevent and treat infection by emerging variants and to minimize the risk of viral escape."23:45
de-facto"To develop prevention and therapeutic strategies, we formed an international consortium to map the epitope landscape on the SARS-CoV-2 Spike, defining and structurally illustrating seven receptor-binding domain (RBD)-directed antibody communities with distinct footprints and competition profiles."23:46
de-facto"Pseudovirion-based neutralization assays reveal Spike mutations, individually and clustered together in variants, that impact antibody function among the communities. Key classes of RBD-targeted antibodies maintain neutralization activity against these emerging SARS-CoV-2 variants."23:48
de-facto.title https://covic.lji.org/database/23:51
Brainstormde-facto: From covic.lji.org: CoVIC-DB Database - Coronavirus Immunotherapy Consortium23:51

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