| Brainstorm | New from Reddit (test): nCoV: White House says more than 400,000 Americans received a Covid booster shot at pharmacies over the weekend → https://is.gd/2LNxO8 | 00:08 |
|---|---|---|
| nixonix | .title https://twitter.com/m_clem/status/1442797794700537861 | 00:10 |
| Brainstorm | nixonix: From twitter.com: Michael Clemens (@m_clem): "Breakthrough cases of polio—including deaths—were common during early polio vaccination. What kept us safe was not perfect vaccine efficacy. It was that Americans quickly & [...] | 00:10 |
| nixonix | .title https://twitter.com/feldman_gil/status/1442851115549200388 maybe this gil dude will regulary post updated pics with english translations? | 00:12 |
| Brainstorm | nixonix: From twitter.com: Gil Feldman (@feldman_gil): "Most updated data from Israel. Left - Actual numbers. Right - per 100K Upper charts: active cases Lower charts: severe cases" | El Pajarito de NoGAFAM | 00:12 |
| nixonix | but if not, use my hebrew - english dictionary, posted earlier! | 00:13 |
| Brainstorm | New from Reddit (test): nCoV: Investment Minister Encourages Vaccination in Papua's Fakfak to Recover Economy | 28SEP21 → https://is.gd/Qf4pjk | 00:30 |
| Brainstorm | New from Reddit (test): nCoV: New Covid cases dip below 10,000 | 28SEP21 → https://is.gd/VOaWaD | 00:41 |
| Brainstorm | New from Reddit (test): nCoV: Active COVID-19 cases decline 13% to 58,000 | 27SEP21 → https://is.gd/S9tKQi | 00:52 |
| Brainstorm | New from Reddit (test): nCoV: Covid: 37% of people have symptoms six months after infection | 28SEP21 → https://is.gd/qt2zSl | 01:03 |
| Brainstorm | New from BBC Health: People also suffer 'long flu', study shows: Similar to Covid, other viruses can cause prolonged symptoms that take time to get over. → https://is.gd/KExoWs | 01:14 |
| de-facto | .title https://datadashboard.health.gov.il/COVID-19/general | 01:15 |
| Brainstorm | de-facto: From datadashboard.health.gov.il: ק×ר×× × - ××× ××§×¨× | 01:15 |
| Brainstorm | Updates for Djibouti: +383 cases (now 12636), +5 deaths (now 167) since 5 days ago | 01:41 |
| LjL | Brainstorm, good to see you handle Hebrew characters so admirably | 01:43 |
| de-facto | they write from right to left | 01:47 |
| LjL | i'm not sure that's all that Brainstorm was having trouble with there ;( | 01:48 |
| de-facto | קורונה - לוח בקרה | 01:48 |
| LjL | thanks, now it's much clearer | 01:49 |
| LjL | (but yes that works) | 01:49 |
| Brainstorm | Updates for Uganda: +95 cases (now 123340), +2 deaths (now 3148), +2614 tests (now 1.7 million) since a day ago | 02:06 |
| lastshell | Does anybody knows how many healthcare workers will be fired for the vaccine mandate ? | 02:09 |
| nixonix | .title https://phys.org/news/2021-09-atypical-cases-mad-cow-disease.html | 02:10 |
| Brainstorm | nixonix: From phys.org: Two atypical cases of mad cow disease detected in Brazil | 02:10 |
| lastshell | dr ZDog mentioned 70,000 but I don't know where he got that number https://www.youtube.com/watch?v=KCTYwJcJSlk | 02:10 |
| nixonix | good thing we dont have bse in europe anymore! | 02:11 |
| lastshell | Today some one die from rabies https://wgntv.com/news/lake-county-man-dies-from-rabies-first-human-case-in-illinois-since-1954/ | 02:11 |
| nixonix | .title https://www.brusselstimes.com/news/world-all-news/185845/mad-cow-disease-case-in-united-kingdom/ | 02:12 |
| Brainstorm | nixonix: From www.brusselstimes.com: Mad cow disease case in United Kingdom | 02:12 |
| pwr22 | <Brainstorm> "New from BBC Health: People also..." <- This is not news to me lol | 02:12 |
| nixonix | good thing they have a good surveillance, and identify all the cases early, so theres no chance we might have eaten them all this time, and then after years, develop cjd! | 02:14 |
| nixonix | "There have been five cases of BSE discovered in the UK since 2014. Each case involved dead animals that never entered the food chain and therefore posed no health risk to the general public. | 02:14 |
| nixonix | basically they identify the cases if they drop dead... | 02:15 |
| nixonix | well, at least sars2 doesnt productively infect immune cells like mers! | 02:21 |
| nixonix | (aka replicating in them too) | 02:22 |
| lastshell | https://www.theguardian.com/world/2021/sep/28/covid-37-of-people-have-symptoms-six-months-after-infection Covid: 37% of people have symptoms six months after infection | 02:23 |
| nixonix | .title https://www.biorxiv.org/content/10.1101/2021.09.27.461948v1 | 02:23 |
| Brainstorm | nixonix: From www.biorxiv.org: Viral replication in human macrophages enhances an inflammatory cascade and interferon driven chronic COVID-19 in humanized mice. | bioRxiv | 02:23 |
| nixonix | maybe tomorrow is better day.. | 02:23 |
| Brainstorm | Updates for France: +2885 cases (now 7.0 million) since 23 hours ago — United Kingdom: +35389 cases (now 7.7 million), +103 deaths (now 136472) since 23 hours ago — French Guiana: +779 cases (now 40569), +6 deaths (now 262), +5830 tests (now 396699) since 3 days ago — Guinea: +18 cases (now 30382), +1377 tests (now 554657) since 20 hours ago | 02:31 |
| Brainstorm | Updates for Curacao: +45 cases (now 16428), +1 deaths (now 162), +3660 tests (now 276344) since 22 hours ago | 03:08 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: AnGes: AG0301-COVID19 → https://is.gd/HrYyfo | 03:23 |
| Brainstorm | New from r/WorldNews: worldnews: Over 1 million Israelis who haven’t had 3rd dose to lose Green Pass on Sunday → https://is.gd/0ErtKP | 03:45 |
| LjL | that seems a bit overkill | 03:52 |
| Brainstorm | New from Politico: Have we reached peak stupidity?: The only cure for our epidemic of idiocy is admitting our ignorance. → https://is.gd/pt3aT7 | 04:07 |
| Brainstorm | New from r/WorldNews: worldnews: Japan to end COVID-19 state of emergency on Thursday → https://is.gd/yTkUK9 | 04:18 |
| Brainstorm | Updates for Canada: +5245 cases (now 1.6 million), +59 deaths (now 27760) since 23 hours ago | 04:35 |
| Brainstorm | New from https://covid19.specops.network : ljl-covid: Change freenode webchat to Libera webchat → https://is.gd/alCN4j | 04:39 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Alaska now has the highest case per capita of any state at any time during the US pandemic pic.twitter.com/Q8i61izCxO → https://is.gd/1IjrZU | 04:50 |
| Brainstorm | Updates for United Kingdom: +35327 cases (now 7.7 million), +135 deaths (now 136514) since 22 hours ago — South Korea: +2883 cases (now 308725), +10 deaths (now 2474), +59687 tests (now 14.5 million) since 22 hours ago — France: +4248 cases (now 7.0 million) since 22 hours ago — Switzerland: +2060 cases (now 837767) since 21 hours ago | 05:00 |
| Brainstorm | New from The Indian Express: World: Pfizer vaccine for kids may not be available until November → https://is.gd/gsgEzd | 05:43 |
| Brainstorm | New from COVID tweets: Josiah Grindrod (@JT_Grindrod): SARS will never be MARS. Dissuade yourself of that notion and the next few years will be easier to deal with. → https://is.gd/4okUAa | 06:04 |
| Brainstorm | New from The Indian Express: World: United Airlines ready to fire workers for defying vaccine mandate → https://is.gd/iBzr3y | 06:26 |
| Brainstorm | Updates for Belgium: +1874 cases (now 1.2 million), +13 deaths (now 25581), +44232 tests (now 19.9 million) since a day ago — Germany: +50 deaths (now 93916) since 13 hours ago | 06:39 |
| Brainstorm | New from r/WorldNews: worldnews: Phase I trial investigates using antiparasitic nitazoxanide for treatment of COVID-19 → https://is.gd/3T3kBX | 06:47 |
| Brainstorm | Updates for New Caledonia, France: +459 cases (now 6838), +8 deaths (now 101) since 23 hours ago — Antigua and Barb.: +237 cases (now 3160), +12 deaths (now 76) since 2 days ago — United Kingdom: +34643 cases (now 7.8 million), +169 deaths (now 136558) since 23 hours ago — France: +5679 cases (now 7.0 million) since 23 hours ago | 07:29 |
| Brainstorm | New from r/WorldNews: worldnews: N.Korea tests new hypersonic missile as it ramps up weapon systems → https://is.gd/cl9EUL | 07:31 |
| Brainstorm | Updates for India: +18870 cases (now 33.7 million), +251 deaths (now 447300) since 23 hours ago | 08:31 |
| Brainstorm | New from The Indian Express: World: At high-level UNGA session, world leaders thank India for COVID-19 vaccine shipments → https://is.gd/DRZbWr | 08:36 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): Alternatively, the difference may stem from many people still having not been exposed to Covid, whereas essentially everyone has built up some immunity to the dominant lineages of flu (influenza A H3N2 and H1N1), which have been in circulation for decades.2/ → https://is.gd/1DfDLG | 08:47 |
| Brainstorm | New from Politico: Content moderation: YouTube deletes RT’s Germany channels over COVID-19 misinformation → https://is.gd/HI7bmz | 08:57 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | September 29, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/FSiChc | 09:08 |
| Brainstorm | New from The Indian Express: World: No choice but to impose travel curbs to contain COVID-19: China → https://is.gd/uXtKXI | 09:29 |
| Brainstorm | New from r/WorldNews: worldnews: Wuhan scientists planned to release coronavirus particles into bats 18 months before outbreak → https://is.gd/mYydWu | 09:50 |
| Brainstorm | Updates for Czechia: +470 cases (now 1.7 million), +1 deaths (now 30455), +36530 tests (now 38.1 million) since a day ago | 10:11 |
| -Bridgestorm- 🌅 地震! Earthquake! 6.5 M tremor, registered by yurekuru, occurred 9 minutes ago (08:37:02 UTC), during twilight, Sea Of Japan (38.98, 135.04) ± 27 km, ↓174 km likely felt 380 km away (in 輪島市…) by 27500 people → https://twitter.com/yurekuru/status/1443132962749382656 https://twitter.com/yurekuru/status/1443132954503307264 — Webcams: https://www.windy.com/webcams/1464485293 https://www.windy.com/webcams/1326803413 | 10:46 | |
| -Bridgestorm- https://www.windy.com/webcams/1602225171 (Twitter) | 10:46 | |
| Brainstorm | New from Reddit (test): CoronavirusUK: Vitamin A nasal drops to be trialled to help restore post-COVID smell loss → https://is.gd/gtlncM | 10:56 |
| Brainstorm | Updates for New Caledonia: +338 cases (now 7176), +13 deaths (now 114), +13772 vaccines (now 141094) since a day ago — Japan: +971 cases (now 1.7 million), +28 deaths (now 17551), +567978 vaccines (now 88.2 million), +80004 tests (now 24.7 million) since 8 hours ago | 11:07 |
| specing | another death to janssen | 11:15 |
| specing | now the death count is at 1 per 2 million | 11:15 |
| specing | or 2 at 2 million, if counting the diplomat's wife that died in belgium | 11:15 |
| specing | (The former was a 20 years old woman) | 11:16 |
| specing | * death not yet confirmed to be linked to janssen, but it was 2 weeks after vaccination | 11:16 |
| Brainstorm | Updates for Estonia: +747 cases (now 155469), +6287 tests (now 1.9 million) since a day ago — Laos: +547 cases (now 23488), +1 deaths (now 17), +7075 tests (now 488876) since 6 hours ago — Papua New Guinea: +380 cases (now 19903), +2 deaths (now 229), +1802 tests (now 188267) since 2 days ago | 11:32 |
| pwr22 | specing: is that controlling for the random amount of deaths we would expect in such a large population anyway? | 11:32 |
| specing | I was not controlling for anything, just reporting | 11:34 |
| Brainstorm | New from BMJ: David Oliver: How hospital doctors’ own pressures affect GPs: Even before covid hit in early 2020, the NHS faced growing pressures from capacity, performance, and demand. GPs in particular had repeatedly sounded the alarm about workforce and workload. A... → https://is.gd/oeKXYE | 11:39 |
| Brainstorm | New from BMJ: Covid grief: medical examiner’s office could be central point of access for counselling and support services: The covid-19 pandemic has shaken the lives of every person in virtually all aspects. We should take a moment to reflect on the impact it has had on all aspects of death, too.Working as medical... → https://is.gd/9PGcr7 | 12:01 |
| Brainstorm | Updates for Finland: +802 cases (now 140889), +17546 tests (now 7.1 million) since 23 hours ago | 12:09 |
| Brainstorm | New from r/Science: science: Social distancing measures in the spring of 2020 effectively curbed the COVID-19 pandemic in Germany. Already within the first three weeks, contact restrictions prevented more than 80 per cent of COVID infections and more than 60 per cent of the deaths that would have followed → https://is.gd/Br1iMs | 12:33 |
| Brainstorm | Updates for Slovakia: +1459 cases (now 411080), +14 deaths (now 12620), +11698 tests (now 3.6 million) since a day ago — Germany: +5803 cases (now 4.2 million) since 19 hours ago — Brunei: +137 cases (now 6950), +1 deaths (now 40), +5791 tests (now 350236) since 23 hours ago | 12:34 |
| Brainstorm | New from The Indian Express: World: China kills 3 housecats that tested positive for Covid-19 → https://is.gd/K0ybcU | 12:56 |
| Brainstorm | Updates for Croatia: +1911 cases (now 403080), +14 deaths (now 8628), +3655 vaccines (now 1.8 million), +19405 tests (now 2.8 million) since 22 hours ago | 12:59 |
| Brainstorm | New from r/WorldNews: worldnews: WHO reports 10 pct global drop in new COVID-19 cases; major decline in Mideast → https://is.gd/edmvMP | 13:28 |
| Brainstorm | Updates for Nepal: +892 cases (now 794163), +8 deaths (now 11123), +10652 tests (now 4.2 million) since 21 hours ago | 13:36 |
| Brainstorm | New from Reddit (test): Global COVID Cases For 29SEP21: Summary As Of: 29SEP @ 11:15 GMT Countries 221 + 2 Cases 233,479,613 Deaths 4,777,127 Recovered 210,240,738 Active Cases 210,451,591 Countries reporting new cases: 94 Countries reporting new deaths: 69 Countries reporting increased Active Cases: 51 Countries reporting decreased Active Cases: 48 [... want %more?] → https://is.gd/XTuuUw | 13:50 |
| Brainstorm | New from Contagion Live: Cardiovascular Disease Diagnoses Remain Elevated 3 Months After COVID-19 Infection: “Compared to the pre-COVID period, the odds ratio for CVD encounters was nearly doubled in each post-COVID period from 31 to 90 days post onset,” Brian Agan, MD, deputy science director and HIV research director of the Infectious Disease [... want %more?] → https://is.gd/XpCZPx | 14:22 |
| Brainstorm | New from r/Science: science: The Kidney Project successfully tests a prototype bioartificial kidney → https://is.gd/L2B9lB | 14:33 |
| Brainstorm | Updates for Romania: +10826 cases (now 1.2 million), +207 deaths (now 36865), +70435 tests (now 12.8 million) since a day ago — Germany: +8080 cases (now 4.2 million) since 21 hours ago — Indonesia: +1954 cases (now 4.2 million), +117 deaths (now 141826), +278567 tests (now 38.8 million) since a day ago — Switzerland: +913 cases (now 838251) since 23 hours ago | 14:38 |
| Brainstorm | New from The Indian Express (Health): Health: Breast milk contains antibodies up to 10 months after Covid recovery, study finds → https://is.gd/Bg7dto | 14:55 |
| Brainstorm | New from Contagion Live: Hospitalization, Death, and COVID-19 Vaccinations: A new study breaks down the risk prediction of death or hospitalization related to COVID-19 in adults following their vaccination. → https://is.gd/0YBowT | 15:05 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Vaxzevria (previously COVID-19 Vaccine AstraZeneca), COVID-19 Vaccine (ChAdOx1-S [recombinant]), COVID-19 virus infection, Date of authorisation: 29/01/2021, Revision: 13, Status: Authorised → https://is.gd/rIyUV1 | 15:17 |
| Brainstorm | New from Johnson&Johnson: Innovation: Janssen Announces Start of Phase 3 Trial for Investigational Respiratory Syncytial Virus (RSV) Vaccine in Older Adults → https://is.gd/EqLUQq | 15:28 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Run on ivermectin tablets leaves less for livestock; Pfizer Covid-19 shot for kids may not come until November → https://is.gd/0zThGv | 15:39 |
| Brainstorm | Updates for Bangladesh: +1178 cases (now 1.6 million), +17 deaths (now 27487) since 22 hours ago | 15:40 |
| Brainstorm | Updates for Qatar: +76 cases (now 236558), +5351 tests (now 2.7 million) since a day ago | 16:05 |
| Brainstorm | Updates for Canada: +47 deaths (now 27773) since 19 hours ago | 16:30 |
| Brainstorm | New from COVID tweets: Dr Emma Hodcroft (@firefoxx66): Huge congratulations and can think of few more deserving of such recognition. Incredibly proud of @trvrb & his contributions both to the pandemic & as a PI of @nextstrain! twitter.com/trvrb/status/1… → https://is.gd/XBGrny | 16:45 |
| Brainstorm | New from COVID tweets: Dr Emma Hodcroft (@firefoxx66): As @LongCovidKris has pointed out - too much travel has addled my brain as of late - it's celebrating it's 11th birthday! Though it does feel like 21 years since 2010, in my defence! twitter.com/firefoxx66/sta… → https://is.gd/MB5R9p | 16:56 |
| Brainstorm | New from StatNews: Health Tech: A new study points to the power of wearables to predict even presymptomatic infections, suggesting use one day against Covid-19 → https://is.gd/rGfpNs | 17:07 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Wednesday 29 September 2021 Update → https://is.gd/kaOOSu | 17:18 |
| Brainstorm | Updates for Chile: +611 cases (now 1.7 million), +6 deaths (now 37455), +46433 tests (now 21.7 million) since a day ago | 17:32 |
| Brainstorm | New from ClinicalTrials.gov: (news): The School SPIT Study - COVID-19 Testing in Secondary Schools → https://is.gd/2OQdgI | 17:50 |
| Brainstorm | New from ClinicalTrials.gov: (news): Post Coronavirus Disease Syndrome Indonesian Population → https://is.gd/zTEkH2 | 18:02 |
| Brainstorm | Updates for United Kingdom: +34190 cases (now 7.8 million), +965014 tests (now 302.3 million) since 15 hours ago | 18:10 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): What are the risks of Covid transmission related to air travel? Still much more to learn, may be different with Delta variant. Boarding process and meal service key liabilitieswsj.com/articles/covid… “I’m disappointed airlines don’t go for scientific approaches." by @MiddleSeat pic.twitter.com/iKJF3XuZW3 → https://is.gd/rjF3Zd | 18:26 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The title tells the story: No Significant Difference in Viral Load Between Vaccinated and Unvaccinated, Asymptomatic and Symptomatic Groups Infected with #SARSCoV2 Delta Variantmedrxiv.org/content/10.110… Findings extend prior reports of Delta asymptomatic infections in vaccinated pic.twitter.com/YYTDZ3td7W → https://is.gd/QLP4sb | 18:59 |
| Brainstorm | Updates for Luxembourg: +132 cases (now 78130), +4774 tests (now 3.5 million) since 23 hours ago | 19:06 |
| Brainstorm | New from WebMD: New Tests for Prostate, Colon Cancer Show Promise: If approved in the United States, the tests could make screening and diagnosis for these cancers easier on patients, without the need for needle biopsy or colonoscopy. → https://is.gd/ciG4QB | 19:11 |
| Brainstorm | Updates for Italy: +3212 cases (now 4.7 million), +63 deaths (now 130870) since 23 hours ago — Canada: +50 deaths (now 27776) since 22 hours ago | 19:31 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): PCR cycle threshold (Ct) ≠ transmission liability/risk.We already know that transmission from vaccinated individuals is low. The magnitude has yet to be quantified. But it can happen. That's why their concluding statement is prudent nad helpful pic.twitter.com/YqPGBKEEYK → https://is.gd/xYwsSG | 19:33 |
| Brainstorm | New from WebMD: More Than 400,000 Americans Have Received COVID Booster Shots: More than 400,000 people in the U.S. have received COVID-19 booster shots at pharmacies since the third dose of the Pfizer-BioNTech vaccine was authorized last week, White House officials announced Tuesday. → https://is.gd/CUwfut | 19:44 |
| Brainstorm | New from r/WorldNews: worldnews: Merck says research shows its COVID-19 pill works against variants → https://is.gd/UWbPtG | 20:26 |
| LjL | again this famous but elusive pill... is it shown to work in humans in the first place? | 20:30 |
| Brainstorm | Updates for Spain: +2761 cases (now 5.0 million), +39 deaths (now 86397) since 23 hours ago | 20:33 |
| Brainstorm | New from Reddit (test): Boh...: submitted by /u/TomfooleryPranks to r/CoronaVirus_ITALIA → https://is.gd/Nvhyvv | 20:37 |
| lastshell | https://www.theguardian.com/commentisfree/2021/sep/27/data-israel-covid-booster-shots-standard the 3rd shot still controversial | 20:59 |
| Brainstorm | Updates for Jordan: +1052 cases (now 822892), +7 deaths (now 10710), +28323 tests (now 10.0 million) since 22 hours ago | 21:10 |
| Brainstorm | New from r/WorldNews: worldnews: Brazil hospital chain accused of hiding Covid deaths and giving unproven drugs → https://is.gd/NEvQsE | 21:20 |
| Brainstorm | New from r/WorldNews: worldnews: Vatican to mandate vaccines for employees → https://is.gd/Rg3lYY | 21:31 |
| Brainstorm | Updates for Germany: +5688 cases (now 4.2 million) since 22 hours ago — Canada: +41 deaths (now 27777) since 23 hours ago | 21:35 |
| Brainstorm | New from Reddit (test): nCoV: Merck says its COVID-19 antiviral pill is effective against variants | 29SEP21 → https://is.gd/Atb1Pv | 21:53 |
| Brainstorm | Updates for Singapore: +2268 cases (now 94043), +8 deaths (now 93) since a day ago | 22:00 |
| Brainstorm | New from WebMD: Worried Parents Scramble to Vaccinate Kids Despite FDA Guidance: One week after reporting promising results from the trial of their COVID-19 vaccine in children ages 5 to 11, Pfizer and BioNTech announced they’d submitted the data to the FDA . But that hasn’t stopped some parents from discreetly getting their children under age 12 vaccinated. → https://is.gd/TBLvka | 22:03 |
| nixonix | shane crotty: "almost all of the adaptive immune response — your antibody and T-cell response — is completely dependent on that first innate immune signal | 22:09 |
| nixonix | so if you dont have enough those circulating abs, you will be late (if your innate immunity is unsuccesful, and the main immune evasion way of sars2 is NSP1 interferon antagonism). even for triggering memory b-cells to proliferate and produce new antibodies | 22:12 |
| nixonix | only 10% of severe cases were found autoantibodies vs type I interferons. but how is it among younger age groups with severe symptoms? old people, if not vaxed, have different immunological defects and other comorbidities, but how about not-old and healty, is it mostly about those autoantibodies? | 22:21 |
| lastshell | nixonix can you lower down to understand | 22:21 |
| nixonix | tell me which part | 22:22 |
| lastshell | if you dont have enough those circulating abs, you will be late (if your innate immunity is unsuccesful, and the main immune evasion way of sars2 is NSP1 interferon antagonism). even for triggering memory b-cells to proliferate and produce new antibodies | 22:22 |
| lastshell | ty | 22:22 |
| nixonix | interferons signal adaptive immune response like killer t-cells and new antibodies secreting memory b-cells, that theres infection going on. and that interferon response is suppressed by sars2 | 22:25 |
| lastshell | ok | 22:25 |
| nixonix | so its best to have recent vaccination, because your adaptive response might be too late because of that suppression | 22:26 |
| lastshell | this is why the booster is need it ? | 22:26 |
| nixonix | yeah, and also the quicker clearing the virus, less chances to also spread it to other people | 22:27 |
| nixonix | theres an alternative way, somehow prevent that immune evasion of inhibiting interferons. chinese have given hospital workers nasal interferon sprays (alpha i think). that doesnt help much if you have autoantibodies against it, though | 22:29 |
| lastshell | what about microdosing with covid by walking indoors with n95 masks that can algo help ? | 22:30 |
| nixonix | and im not sure if that is healthy to continually take interferons. if i recall alpha is safer than beta (there subtypes of them), but for treatment it hasnt been very good, prob because comes too late, like in hospital | 22:30 |
| nixonix | also there are some synthetic modified interferons that humans dont have autoantibodies. not sure if proven beneficial, and the same timing problem probably | 22:30 |
| nixonix | who knows it that develop some cellular reactivity that would remain. like maybe half the people have cellular reactivity from other betacoronaviruses to conserved common epitopes (in S2 or N), which could be both beneficial and perhaps detrimental (the latter according to that paper that compared kids vs adults) | 22:32 |
| nixonix | if=if (and was about that "microdosing") | 22:33 |
| nixonix | could that autoantibody problem vs interferons somehow be fixed? | 22:34 |
| lastshell | thats the question | 22:35 |
| nixonix | they found 10% of severe patients those autoantibodies vs interferons, but only 3.5% genes causing it. maybe the rest is genetic too, but they just havent identified the right genes | 22:36 |
| nixonix | and there are ways to fix genes. yeah, not likely that would be solution for masses any time soon | 22:36 |
| nixonix | leonardi thinks humans will be selected by trait with sars2, like happened in east asia 25k - 5k years ago with some other coronaviruses | 22:38 |
| nixonix | i think there will be solution, but it will take time. fixing those genes, if it really is that big factor | 22:38 |
| nixonix | .title https://www.abc.net.au/news/science/2021-06-25/coronavirus-epidemic-east-asia-twenty-thousand-years-ago/100226362 | 22:39 |
| Brainstorm | nixonix: From www.abc.net.au: Coronavirus epidemic broke out in East Asia around 25,000 years ago, gene study shows - ABC News | 22:39 |
| nixonix | damn. above should have been it=if (not if=if) | 22:44 |
| nixonix | .title https://www.science.org/doi/10.1126/science.abj3624 this is interesting, and could have a bigger effect than autoantibodies vs interferons have (when they were found only on 10% of severe cases) | 22:59 |
| Brainstorm | nixonix: From www.science.org: A prenylated dsRNA sensor protects against severe COVID-19 | 22:59 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): The fact they claim 'the virus will attenuate by endemicity' and 'liberals can't leave lockdown' and 'your unvaccinated kid is like a vaccinated grandparent' means they are propagandists not scientists twitter.com/EpicDelegator/… → https://is.gd/DaczGy | 22:59 |
| nixonix | some people have hydrophobic version of rna sensor that anchores to cell membrane, and is more effective. africans usually have that better versions, but people outside africa have the worse version | 23:01 |
| nixonix | they have a few genetic regions listed. not sure where would be the full list, but there's something here: | 23:09 |
| nixonix | .title https://www.nature.com/articles/s42003-021-01681-6 | 23:09 |
| Brainstorm | nixonix: From www.nature.com: Genetic ancestry plays a central role in population pharmacogenomics | Communications Biology | 23:09 |
| nixonix | human genome project something should have the full list, i think | 23:10 |
| nixonix | damn science's pdfs, now i cant even use search with them... there must be some solution. what would be a good pdf editor to try? | 23:13 |
| lastshell | not sure if libreoffice allow to edit pdf | 23:16 |
| nixonix | what i read it depends on pdf, if editing or removing those watermarks etc is easy, somehow possible, or very hard | 23:17 |
| lastshell | also for command line exist pdftk but I used more for cut and join pages in pdfs | 23:18 |
| nixonix | pdftotext, pdftoolkit, libre or word, some pdf editors, web tools possibly... some things to try. easier is to use the web version of the article, if available | 23:18 |
| nixonix | but if anyone finds the solution for some of those pdf's that cause problem to make them right, like those new science's, let me know. too bad when you cant search or copy-paste text | 23:22 |
| Brainstorm | New from CIDRAP: CDC urges COVID-19 vaccination in pregnancy: Stephanie Soucheray | News Reporter | CIDRAP News Sep 29, 2021 Also, CDC data show similar side effects after a third Pfizer vaccine dose as seen after the second dose. → https://is.gd/scGQft | 23:22 |
| nixonix | anyways, thats good news, kinda. maybe solution behind lot of severe cases, and possibly mild too. only problem is, its pretty hard to fix... | 23:24 |
| de-facto | uhm leonardi thinks we will have that many fatalities that SARS-CoV-2 will have selection on human genome? | 23:32 |
| de-facto | that would mean a horrible lot of young fatalities | 23:34 |
| nixonix | in the long run. those with better genes (it was about autoantibodies vs interferons then, but prob genes favoring hydrophobic OAS1 too) survive more often, and will be selected for future generations | 23:35 |
| specing | yeah, and young people just aint dying yet | 23:35 |
| specing | well, dying from other preventable causes, maybe? | 23:36 |
| lastshell | but we saw a shift in patience mid age going down this year ? | 23:36 |
| lastshell | is that related ? | 23:36 |
| nixonix | we dont know what are the consequences with frequent reinfections, with different organ damages etc. sure with one infection its not that bad, mortality wise, for young. but how about during years and decades | 23:37 |
| nixonix | well, vaccines will improve, and govt will be more willing to allow boosters | 23:37 |
| nixonix | governments | 23:37 |
| nixonix | and to vaccinate kids too | 23:37 |
| lastshell | they need to sort out the myocarditis issue | 23:38 |
| nixonix | its mostly because young people are less willing to vax, and also later in order. no information, at least confirmed, these later variants would be worse to young, meaning more even age-severity curve | 23:39 |
| nixonix | i think | 23:39 |
| cfwi | they are offering "boosters" here now, not sure if I want one | 23:39 |
| de-facto | i dont think (and really do hope) it will not become as deadly as killing that many young people before they were able to reproduce that COVID will leave a mark on human genome | 23:41 |
| de-facto | that would be absolutely horrible scenario | 23:41 |
| nixonix | myocarditis issue is very minor. az's thrombosis issue isnt, and they havent fixed it | 23:41 |
| lastshell | true | 23:42 |
| Brainstorm | New from Contagion Live: COVID-19 Breakthrough Infections: How We Got Here: An expert explains the science of vaccine- and infection-induced immunity, and how it informs the timeline of COVID-19 outbreaks this year. → https://is.gd/IpvIMC | 23:43 |
| nixonix | it wouldnt need to be that big effect, selection, when it affects during generations. also not only about deaths, but healthiness. sure lots of that organ damage will be issue only later in life than the typical reproduction years, but it adds up anyway | 23:43 |
| nixonix | and its just one infection we know about (and lots of damage done we dont and wont know about, the full scope, until years or decades have gone). how about after 5 or 10 reinfections? | 23:45 |
| de-facto | since current mutants are not able to do such extended fatalities it would require tolerating much more breeding to make it more aggressive and deadly, i really hope humanity is not stupid enough to tolerate that to happen | 23:48 |
| lastshell | this are the current requirements for the 3rd shot: | 23:48 |
| lastshell | 65 years and older | 23:48 |
| lastshell | 50-64 with severe risk for COVID-19 | 23:48 |
| lastshell | 18-49 with underlying medical conditions | 23:48 |
| lastshell | have exposure to COVID-19 through their occupation or institutional setting | 23:48 |
| nixonix | .title https://twitter.com/NickytaLeb/status/1443013011288072192 | 23:48 |
| Brainstorm | nixonix: From twitter.com: NK Leb (@NickytaLeb): "👇👇👇 "Many people still think they will only get it once. Because that is what they were told initially. And the bait-and-switch to "everyone will get it many times" happened [...] | 23:48 |
| lastshell | (pfizer) | 23:49 |
| nixonix | depending on place or vax site, they just go and get the jab if they feel they want the 3rd. often nothing is asked (usa), but sometimes they refuse | 23:49 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): So basically, they are trying to exert a chilling effect on rationales that suggest we cannot be parsimonious with third dosesThat's because monetary parsimony at the expense of the public's health has been at the forefront of this pandemic → https://is.gd/NjhzQF | 23:54 |
| nixonix | .title https://danderyds-sjukhus.mynewsdesk.com/pressreleases/markant-nedgaang-i-antikroppsnivaaer-7-maanader-efter-pfizer-slash-biontechs-vaccin-comirnaty-3131960 put this to google translate (waned to 15% in sweden in 7 months) | 23:56 |
| Brainstorm | nixonix: From danderyds-sjukhus.mynewsdesk.com: Markant nedgång i antikroppsnivåer 7 månader efter Pfizer/BioNTechs vaccin Comirnaty | Danderyds Sjukhus AB | 23:56 |
| nixonix | they also say something like, according to sources, protection vs severe should still be ok | 23:57 |
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