| Brainstorm | Updates for Bahrain: +52 cases (now 274977), +15544 tests (now 6.4 million) since 22 hours ago | 00:04 |
|---|---|---|
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The Phase 3 randomized, placebo-controlled monoclonal antibody combination trial in outpatients with Covid: marked reduction in risk of hospitalization and death @NEJM nejm.org/doi/full/10.10… pic.twitter.com/Z3ECsQo511 → https://is.gd/PwekBa | 00:05 |
| lastshell | https://www.haaretz.com/amp/israel-news/mass-inoculation-over-next-days-will-end-israel-s-covid-wave-senior-official-says-1.10248467 | 00:09 |
| nixonix | australia is very interesting to follow, because they still take every case very seriously (unlike other western world, excl nz). now cases are going down in sydney, but increasing in melbourne (that is closest to south pole, from big cities) | 00:11 |
| nixonix | very little leaked outside of those two metropolitan areas. and even less to other states | 00:12 |
| nixonix | somehow they can just ban travelling between states, and federal govt has no say in it | 00:13 |
| nixonix | i think they do 3rd degree contact tracing there, so that not only those places where cases had visited and people who then visited them, but only those other peoples contacts will be traced | 00:15 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The pivotal trial of the Astra-Zeneca vaccine in over 32,000 participants, published today @NEJM. Vaccine efficacy 74% [95% CI 65,80] vs symptomatic infections; maintained across subgroups, age > 65: 84% [54,84] nejm.org/doi/full/10.10… pic.twitter.com/dlwRnrvyc0 → https://is.gd/yAcbRa | 00:16 |
| imaginary | pre-delta screening :( | 00:21 |
| aanna | hi | 00:22 |
| nixonix | "The cutoff date for the primary analysis was March 5, 2021" | 00:22 |
| imaginary | nixonix: yeah, i was feeling optimistic | 00:23 |
| nixonix | well the part that was in latin america, is variants usually more immune evasive than delta. but when it wasnt delta, theres lots of uncertainty if the protection with delta is only slightly reduced (when those unvaxed will also get delta infection more easily), or if there are other factors like high viral loads reducing VE more, compared to | 00:25 |
| nixonix | unvaxed | 00:25 |
| aanna | de-facto: apparently much of the existing genome contains old viruses | 00:25 |
| nixonix | every study should now include time from the last vax dose | 00:27 |
| nixonix | and vax intervals used | 00:27 |
| nixonix | dose | 00:27 |
| imaginary | studies that start including that info are probably coming out in late 2021/early 2022 :( | 00:28 |
| aanna | I'm 8 months from last dose, they require attestion to get the booster, | 00:28 |
| dTal | This "cold" going round in the UK looks nasty | 00:32 |
| dTal | it's not covid but you'd hardly tell the difference in most people | 00:32 |
| imaginary | dTal: oh? anything we could read about that? | 00:33 |
| dTal | coughing, knocks you back for days to up to a week | 00:33 |
| dTal | imaginary: I don't anything more about it than the fact that everyone around me is suddenly sick, and it's all over the news too | 00:33 |
| dTal | just google "worst cold ever uk" | 00:34 |
| nixonix | yet another genetic trait in play: We tested the specific hypothesis that inborn errors of Toll-like receptor 3 (TLR3)– and interferon regulatory factor 7 (IRF7)–dependent type I interferon (IFN) immunity that underlie life-threatening influenza pneumonia also underlie life-threatening COVID-19 pneumonia | 00:36 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Predicting functional changes from amino acid sequence of #SARSCoV2 spike protein receptor binding domain via training a deep neural network, of potential utility to forecast impact of future variants @PNASNews pnas.org/content/118/42… #AI pic.twitter.com/tkvyu5qtL2 → https://is.gd/mzx70D | 00:37 |
| dTal | "training a deep neural network" i.e. eyeballing it and guessing | 00:38 |
| nixonix | but there are lots of other genes. foxp4 (lung symptoms) and foxp3 (t-cell activation and death) comes to my mind | 00:40 |
| nixonix | dont get cold. it damages mucous membranes which then allow easier infecting by sars2 (source some finnish hc official) | 00:42 |
| dTal | I mean it's also deeply unpleasant in its own right | 00:43 |
| nixonix | and flu+rona at the same time is supposedly very bad, or can be. they claim now when restrictions have been reduced, there will be flu around next winter | 00:44 |
| dTal | I read that the immune response from a cold can stop an incubating rona infection stone cold | 00:45 |
| nixonix | if its rhino, which beats rona easily in cells. but most colds are some other viruses | 00:46 |
| ublx | what | 00:47 |
| ublx | so we just need to give everyone rhinoviruses constantly? | 00:47 |
| nixonix | not sure if i remember reasoning for that, but i could guess its about interferons, that rhino infection amplify. rona is very sensitive to interferons compared to most other viruses, but its very efficient in suppressing them (maybe not enough during rhino infection) | 00:47 |
| nixonix | timing would need to be right. it will beat rona even if rhino is inoculated 24h later | 00:48 |
| nixonix | .title https://academic.oup.com/jid/article/224/1/31/6179975 | 00:48 |
| Brainstorm | nixonix: From academic.oup.com: Human Rhinovirus Infection Blocks Severe Acute Respiratory Syndrome Coronavirus 2 Replication Within the Respiratory Epithelium: Implications for COVID-19 Epidemiology | The Journal of Infectious [...] | 00:48 |
| nixonix | yeah interferons "We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication | 00:50 |
| nixonix | prob alpha or beta which use the same receptor complex in most cells | 00:51 |
| ublx | wonder how many people getting bad course of this bad UK cold have already had asymptomatic covid | 00:54 |
| ublx | but i suppose long unchallenged immune systems is the most parsimonious explanation | 00:56 |
| Brainstorm | New from r/WorldNews: worldnews: Companies listing being vaccinated as a requirement in job postings s "jumped 20 times" → https://is.gd/3YTEMB | 00:58 |
| sdfgsdfg | had a terrible case of conjunctivitis a few weeks ago, then got flu symptoms.My eye was swollen the next day, headache got worse. They say ocular symptoms are heavier in delta | 01:02 |
| sdfgsdfg | maybe its true, but my test was negative | 01:02 |
| sdfgsdfg | I could swear it was rona though, never had anything like that | 01:02 |
| sdfgsdfg | maybe the test is shit, or they don't shove the swab far deep enough | 01:03 |
| nixonix | what cold virus or viruses are there around now, in uk? | 01:07 |
| nixonix | its not (supposedly) about some generic immune system challenge, or lack of it. it only affects if its similar enough, so there is protectivity (or perhaps interference causing worse symptoms sometimes) | 01:10 |
| pwr22 | All of them 😛 | 01:10 |
| nixonix | but if two different infections happen close to each other, immune system might not be fully recovered for the next one. also if you get cold soon after vaccine dose, that could possibly affect things like b-cell affinity maturation | 01:12 |
| nixonix | .title https://bjo.bmj.com/content/early/2021/07/08/bjophthalmol-2021-319450 i dont remember about eye symptoms during active rona, but remembered this one | 01:16 |
| Brainstorm | nixonix: From bjo.bmj.com: Corneal confocal microscopy identifies corneal nerve fibre loss and increased dendritic cells in patients with long COVID | British Journal of Ophthalmology | 01:16 |
| nixonix | would prob be much easier to make some viral vector delivery thinga than fragile mrna in nanoparticles, for biohacking those interferon and TLR genes | 01:22 |
| Brainstorm | Updates for Gibraltar: +9 cases (now 5541), +1120 tests (now 360302) since a day ago | 01:31 |
| Brainstorm | New from Ars Technica: Science: Health workers get panic buttons as COVID deniers get violent → https://is.gd/jq9UB7 | 01:45 |
| LjL | <ublx> but i suppose long unchallenged immune systems is the most parsimonious explanation ← that scares me wrt cold and flu | 01:45 |
| nixonix | its only if there is cross-protection between viruses. and there are over 200 known human respiratory viruses | 01:49 |
| nixonix | sure on population level, some oc43 epidemic and like is a bit worse after long pause | 01:50 |
| ublx | for viral/immune dynamics reasons? | 01:50 |
| nixonix | whats that | 01:51 |
| nixonix | "The team found that 20% of people hospitalized with severe COVID-19 had high or intermediate levels of autoantibodies to type I IFNs. Autoantibodies were also found in at least 18% of people who died from the disease. In contrast, people with no or mild symptoms had very low levels of these autoantibodies. The researchers estimate that the | 01:51 |
| nixonix | autoantibodies may account for about 20% of total fatal COVID-19 cases | 01:51 |
| nixonix | so they found 20%, the other study back then found 10% | 01:52 |
| nixonix | The risk of having such autoantibodies increased with age. For example, while fewer than 10% of people under the age of 40 with severe COVID-19 had active levels of these autoantibodies, more than 21% of those over the age of 80 had them. The researchers also found evidence of autoantibody production in uninfected volunteers. They were found in | 01:52 |
| nixonix | less than 1% of people between 18 and 69 years; in 2.3% of those between 70 and 79 years; and in 6.3% of those 80 years and older. This suggests that type I IFN autoantibodies existed before infection and become more common past age 70 | 01:52 |
| nixonix | increasing the risk to 20x or more for middle-aged and younger. but less increase among old | 01:53 |
| nixonix | "In a related paper published in the same issue of Science Immunology, the researchers identified another rare genetic defect that occurs only in men and results in disruption of IFN production. They estimated that this genetic risk factor accounts for at least 1% of cases of life-threatening COVID-19 in men under the age of 60. | 01:53 |
| nixonix | .title https://www.nih.gov/news-events/nih-research-matters/misdirected-antibodies-linked-severe-covid-19 | 01:54 |
| Brainstorm | nixonix: From www.nih.gov: Misdirected antibodies linked to severe COVID-19 | National Institutes of Health (NIH) | 01:54 |
| nixonix | “We can neatly explain much of severe COVID-19 as a net defect in type I IFN,” Casanova says. “To an extent never seen for any other acute infectious disease, these… studies collectively provide a molecular and immunological explanation for about 20% of critical cases.” Autoantibodies against IFNs—at even very low levels—can be | 01:55 |
| nixonix | screened for in the clinic. | 01:55 |
| nixonix | another new study found infected macrophages in humans, but no increased cytokine or inflammatory signalling from them, and found no replicating. even went as far as thinking it might be protective thing, macrophages collecting virions away from circulation. ADPC | 01:59 |
| nixonix | *ADCP probably (antibody-dependent cellular phagocytosis, using heavy chain end of IgG abs) | 02:02 |
| nixonix | .title https://journals.asm.org/doi/10.1128/mBio.01987-21 | 02:03 |
| Brainstorm | nixonix: From journals.asm.org: Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages | mBio | 02:03 |
| nixonix | seems to be different in mice then, if true | 02:05 |
| nixonix | .title https://www.nature.com/articles/s41591-021-01540-1 not very interesting imo, exp the quote that follows | 02:06 |
| Brainstorm | nixonix: From www.nature.com: Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection | Nature Medicine | 02:06 |
| nixonix | "High levels of protection were noted after vaccination with one dose of a lipid nanoparticle RNA vaccine, despite modest levels of neutralizing antibody, strongly supporting the concept that other mechanisms are at play as co-correlates of protection | 02:06 |
| nixonix | We have previously shown that a wide range of Fc-mediated antibody functions are induced by vaccination, and it is possible that these functions may be important in the absence of neutralizing antibody34. Furthermore, strong T cell responses induced by ChAdOx1 nCoV-19 may contribute to protection14,16 and have been associated with recovery from | 02:06 |
| nixonix | COVID-19 disease | 02:06 |
| LjL | why does this feel like deja vu | 02:20 |
| LjL | <Brainstorm> New from Reddit (test): Covid2019: Llama antibodies have ‘significant potential’ for treating COVID, UK health officials say: nanobodies produced by a llama named Fifi were found to have high efficacy against COVID-19 in hamsters, a first step toward developing a drug for humans. | 02:21 |
| LjL | haven't we heard that sort of thing already several times... several months ago? and it's still at "a first step"? | 02:21 |
| LjL | $ grep -i llama */*covid-19*/* */*coronavirus/* | grep -i nanobod | wc -l | 02:22 |
| LjL | 10 | 02:22 |
| LjL | sometimes it feels like this is a slow motion farce | 02:22 |
| Brainstorm | Updates for France: +5057 cases (now 7.0 million) since 21 hours ago — United Kingdom: +25898 cases (now 7.8 million), +122 deaths (now 136636) since 21 hours ago | 02:33 |
| Pawel[m]1 | My opinion: Seems like Norway is not going to continue with "life full of fear of covid". I'm happy to see that. Sounds like a reasonable approach to me, although I know you lot will be unhappy about my saying this. | 02:35 |
| Pawel[m]1 | Based on: https://www.thelocal.no/20210924/norway-to-ease-covid-19-travel-rules-in-phased-plan/ | 02:35 |
| LjL | that does seem like a very personalized interpretation of what Norway is actually doing or at least being reported as doing | 02:40 |
| LjL | i will note various european countries have tightened and relaxed... and tightened and relaxed again... their travel restrictions at various points in time, depending on how things were going | 02:41 |
| LjL | i also question the usefulness of a "you lot" approach to discussion, but whatever | 02:41 |
| nixonix | [Wednesday, July 15, 2020] [12:59:46 AM EEST] <nixonix> they are small, and may fit better in target sites and be more effective than human antibodies | 02:42 |
| LjL | nixonix, i know, right? why do they make it sound like they're still at the very earliest stage of research and it's a new thing they've just found out? if it's useful, dammit, let's use them. if it's not let's not. | 02:42 |
| nixonix | i also wrote: "yeah i thought it right when i read, that just use llamas, not camels (hopefully no MERS in llamas) | 02:43 |
| LjL | oh so that's why you were wondering if llamas can catch MERS | 02:44 |
| nixonix | also lactoferrin from cows was in discussion in summer 2020 (we had it here again this summer, cant remember who was selling it, maybe it was finns) | 02:45 |
| LjL | lol, you quote yourself talking about those, i'll quote myself talking about that | 02:47 |
| LjL | freenode/##covid-19/2020-10-30.log:[05:30:32] <LjL> but this lactoferrin leaves me perplexed, at least as a prophylactic, because i understand it sequesters iron for the body. that might be good to hinder the virus, but it's not too good if you end up with an iron deficiency | 02:47 |
| LjL | but you have better memory than i do, i remembered about llama/camel nanobodies but lactoferrin... not really | 02:47 |
| nixonix | and chicken eggs i think, IgY: "chicken monoclonal IgY antibodies proved to be more specific when compared to polyclonal antibodies in recognizing a single unique epitope | 02:48 |
| LjL | oh so clearly the reason we don't use these things is a chicken-egg problem | 02:48 |
| nixonix | its a circle! like 90s in fashion again etc | 02:48 |
| Brainstorm | New from r/WorldNews: worldnews: U.S. successfully flight tests Raytheon hypersonic weapon -Pentagon → https://is.gd/3nSYKQ | 02:49 |
| nixonix | from that july 2020 lactoferrin discussion: "human milk include IL-1β, IL-6, IL-8, IL-10, TNFα, and IFN-γ | 02:54 |
| nixonix | maybe better not inject it | 02:55 |
| dTal | they keep running out of human milk at the store | 02:57 |
| dTal | at least, they never have it when I go | 02:57 |
| LjL | i trust that nixonix has been reminded he needs to go buy his human milk real quick before the store runs out later in the morning | 03:05 |
| Brainstorm | Updates for Zambia: +90 cases (now 209002), +1 deaths (now 3648), +6983 tests (now 2.5 million) since a day ago | 03:11 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In today's @NEJM, 120 healthcare workers with breakthrough infections (> 6 months out, Pfizer), 85 (71%) symptomatic, 61% contacts (of those w/likely source) were fully vaccinated, median Ct 22, rapid tests missed many nejm.org/doi/full/10.10… pic.twitter.com/oHi6xWwub0 → https://is.gd/eX2aTl | 03:21 |
| lastshell | where I am there is a shortage again of toilet paper | 03:27 |
| lastshell | no idea why | 03:27 |
| lastshell | this remindme of the first days of the pandemic | 03:28 |
| Brainstorm | Updates for Cameroon: +6889 cases (now 92303), +91 deaths (now 1459) since 10 days ago — Guadeloupe: +445 cases (now 53585), +12716 tests (now 457511) since 4 days ago | 03:36 |
| LjL | lastshell, in the UK there is a shortage of petrol. apparently part of it is due, you know, an actual shortage of petrol, but it's mostly fueled (...not) by the fact that because people *think* there's going to be a lack of petrol, they'll hoard it | 03:42 |
| LjL | English has the phrase "self-fulfilling prophecy" that i'm not sure how many other languages have, at least i think not mine | 03:42 |
| Brainstorm | New from COVID tweets: Pink 🍚 (@PinkWug): @shoe0nhead Workplace safety is one of the most important worker's rights. It depends on how dangerous you think covid is, but personally, I don't know if I can go to a job knowing people around me might not be vaccinated, especially when I live with people who are more vulnerable. → https://is.gd/Pu2rcD | 03:42 |
| jbwncster | LjL: https://www.newsobserver.com/news/state/north-carolina/article254580002.html | 03:44 |
| LjL | why is Brainstorm posting from someone who's not at all in my COVID list ;( | 03:44 |
| lastshell | LjL yeah I hear is a supply issue | 03:46 |
| LjL | jbwncster, don't know what to say about these reports, honestly. it irks me when people on Reddit (at least i usually witness it on Reddit) gloat about anti-vaxxers dying from COVID. i assume there is no gloating in this case, but, gah, "On the night of Sept. 26, after it was certain her son wasn’t going to survive, Demello wrote a goodbye on Facebook." - i... let this be my implicit judgment on the parent(s) and the media | 03:49 |
| jbwncster | It’s kinda sad | 03:50 |
| Raf[m] | When he went to the doctor’s office, however, Gilreath found out he had a sinus infection. It was a few days before he could get a prescription for oral antibiotics filled and start taking the medicine. By that point, the infection had combined with a staph infection and had started to move toward his brain, Demello said. | 04:07 |
| LjL | oh, i just thought i was about as braindead as him since i read about the sinus infection and yet missed that antibiotics prescription "detail" | 04:18 |
| LjL | but turns out the article mentions the sinus infection caused the death twice, and i only read the other part | 04:18 |
| Raf[m] | yeah, I couldn't understand what they meant by sinus infection. it seems unrelated to COVID. and then he had the staph infection, so what did he really die from? | 04:25 |
| LjL | i don't know, but it's long been the standard here (unless it stopped, but it definitely used to be) to give antibiotics to people hospitalized with COVID, because there are many opportunistic infections | 04:26 |
| LjL | the direct cause of death may not be COVID but if you get a random bacterial infection that you mostly likely wouldn't have gotten without having a serious case of COVID, then... | 04:26 |
| Brainstorm | Updates for Canada: +4282 cases (now 1.6 million) since 23 hours ago — Bermuda: +99 cases (now 5244), +10 deaths (now 72), +3798 tests (now 541307) since a day ago — Anguilla: +20 cases (now 409), +3983 tests (now 42919) since a day ago | 04:38 |
| Raf[m] | <LjL> "the direct cause of death may..." <- Touche | 04:47 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Good news: US Hospitalizations are declining >1,000 a day, test positivity now < 6% for the first time since July, new cases are down 14% in past weekBad news: Over 2,300 deaths reported todaynewsnodes.com/us pic.twitter.com/cnhUnyNE2g → https://is.gd/7xbW8v | 04:57 |
| Brainstorm | Updates for United Kingdom: +26367 cases (now 7.8 million), +115 deaths (now 136673) since 21 hours ago — France: +4710 cases (now 7.1 million) since 21 hours ago — New Zealand: +33 cases (now 4160), +16537 tests (now 3.4 million) since 21 hours ago | 05:03 |
| Brainstorm | New from COVID tweets: Eric Feigl-Ding (@DrEricDing): ⚠️NATURAL IMMUNITY versus VACCINES—Which is stronger? Let’s compare reinfection breakthroughs vs vaccine breakthroughs: ➡️Natural immunity is **MUCH weaker than vaccine** protection. By how much? HUGE—Vaccine is 📌9x stronger in May, 📌2x stronger during #DeltaVariant.🧵 #COVID19 [... want %more?] → https://is.gd/XNKfMn | 05:18 |
| Brainstorm | Updates for Belgium: +2589 cases (now 1.2 million), +14 deaths (now 25595), +55744 tests (now 20.0 million) since 23 hours ago — Pakistan: +1742 cases (now 1.2 million), +39 deaths (now 27729), +52635 tests (now 19.4 million) since 23 hours ago | 06:05 |
| LjL | <Brainstorm> New from r/WorldNews: worldnews: Ontario now recommending against Moderna vaccine for men 18-24 → https://is.gd/qUiR7P | 06:07 |
| LjL | still due to myocarditis | 06:07 |
| Brainstorm | New from r/WorldNews: worldnews: Ontario now recommending against Moderna vaccine for men 18-24 → https://is.gd/gl2Zp3 | 06:10 |
| Brainstorm | Updates for Germany: +73 deaths (now 93989) since 23 hours ago | 06:30 |
| Brainstorm | New from The Indian Express: World: Melbourne cases hit pandemic record even as lockdown nears two months → https://is.gd/DYKhbE | 07:24 |
| Brainstorm | Updates for Sarawak, Malaysia: +2967 cases (now 207137) since a day ago — United Kingdom: +18337 cases (now 7.8 million), +155 deaths (now 136713) since 13 hours ago — France: +3018 cases (now 7.1 million) since 4 hours ago — Lombardy, Italy: +438 cases (now 883343), +5 deaths (now 34037) since a day ago | 07:32 |
| Brainstorm | New from BMJ: Seven days in medicine: 22-28 September 2021: Covid-19Youngest are least willing to have vaccineA survey in EClinicalMedicine of over 27 000 schoolchildren aged 9-18 in Berkshire, Buckinghamshire, Oxfordshire, and Merseyside found that only 36%... → https://is.gd/X0YKNB | 08:07 |
| Brainstorm | Updates for India: +23529 cases (now 33.7 million), +189 deaths (now 447507) since 22 hours ago — Kyrgyzstan: +6 cases (now 178450), +3492 tests (now 1.7 million) since 23 hours ago | 08:34 |
| Brainstorm | New from COVID tweets: Tyler Black, MD (@tylerblack32): Oklahoma data showing that the reinfection rate of previously infected people is double the breakthrough rate of previously vaccinated people. pic.twitter.com/Z8yzEURcSn → https://is.gd/o2wK8a | 08:49 |
| Brainstorm | New from The Indian Express (Health): Health: Is it safe to undergo joint replacement surgery during Covid-19 pandemic? → https://is.gd/Zs9uts | 09:11 |
| Brainstorm | Updates for St. Kitts and Nevis: +27 cases (now 1918), +1 deaths (now 13), +2702 tests (now 41035) since a day ago | 09:36 |
| Brainstorm | Updates for Laos: +358 cases (now 23846), +1 deaths (now 18), +6337 tests (now 495213) since 23 hours ago — India: +170 deaths (now 447568) since 15 hours ago | 10:38 |
| Brainstorm | New from StatNews: Opinion: Repurposing drugs can speed new treatments for Covid-19: Drug repurposing has saved lives during the pandemic. Veklury (the brand name for remdesivir) was originally developed to fight Ebola. Others are in the pipeline. → https://is.gd/4efm7D | 10:47 |
| sdfgsdfg | I hope this was the last wavve | 11:01 |
| sdfgsdfg | things can't get worse than this right ? | 11:01 |
| undefined_bob | they can | 11:02 |
| sdfgsdfg | how so | 11:02 |
| undefined_bob | for example a new mutation against which the vaccine doesn't work well | 11:02 |
| undefined_bob | and the whole shit can start from fresh | 11:03 |
| sdfgsdfg | nah, should be fine | 11:07 |
| undefined_bob | depends | 11:11 |
| Brainstorm | New from BMJ: The BMJ Awards 2021: “Landmark” study on dexamethasone wins paper of the year: Researchers whose rapid investigations into possible covid treatments that helped to save over a million lives worldwide have won a top prize in this year’s BMJ Awards.The Recovery collaborative... → https://is.gd/ftLmCE | 11:19 |
| Brainstorm | New from BMJ: The UK should take the lead in pushing for reform of WHO, MPs say: The covid-19 pandemic put a spotlight on the “shortcomings” of the World Health Organisation, highlighting its lack of the funds, power, and independence to respond appropriately, a report by the... → https://is.gd/gwNCj9 | 11:41 |
| Brainstorm | Updates for Poland: +1205 cases (now 2.9 million), +27 deaths (now 75650), +39449 tests (now 20.9 million) since 23 hours ago — Estonia: +788 cases (now 156257), +5 deaths (now 1357), +6150 tests (now 1.9 million) since 19 hours ago — Germany: +10455 cases (now 4.2 million) since 23 hours ago | 11:41 |
| dTal | undefined_bob: I think if that happens we'll see a rather different response this time around | 11:59 |
| undefined_bob | dTal: you mean more stupidity? | 12:00 |
| undefined_bob | well, pfizer said they can adjust their vaccine pretty fast, at least | 12:01 |
| dTal | It'll be brushed off | 12:01 |
| undefined_bob | not until a massive spike in cases | 12:02 |
| undefined_bob | the adjustment will take time, the vaccination of a huge part of the people will take time and so on. but yes, I do think it will went better than in the beginning of all this | 12:03 |
| dTal | no I mean that many places have simply given up | 12:03 |
| dTal | if there's a new variant, the prevailing attitude will be "you just have to live with it, back to work" | 12:04 |
| undefined_bob | like Texas and Florida? | 12:04 |
| dTal | We're basically already there with Delta | 12:04 |
| undefined_bob | true | 12:04 |
| dTal | UK lifted all restrictions at the peak of a massive wave of Delta infection | 12:05 |
| dTal | because that was the date they'd set, and they'd already pushed it back once | 12:05 |
| undefined_bob | yes, I read about that. Cant find nice words for that | 12:05 |
| undefined_bob | cases are still high in the UK as far as I know | 12:06 |
| Brainstorm | New from BMJ: The BMJ Awards 2021: Research paper of the year: “Dexamethasone in hospitalized patients with covid-19,” by the Recovery Collaborative GroupThe BMJ’s judges said this “landmark trial” had a “profound impact” on outcomes for people with covid-19... → https://is.gd/KTxqz1 | 12:13 |
| SpearRaven | get vaccinated to save your own life no matter if all the conspiracies are true. no doubt some are | 12:22 |
| Brainstorm | New from BMJ: The BMJ Awards 2021: Outstanding contribution to health: Think back to high summer and the lure of so called “Freedom Day.”1 Were you revelling in the streets on 19 July as ministers withdrew covid restrictions? Or were you, like Michael Marmot, home... → https://is.gd/GZ7pdI | 12:24 |
| pwr22 | <dTal> "if there's a new variant, the..." <- Unless it starts killing people a lot again | 12:25 |
| pwr22 | If it overwhelms healthcare and death rates rise to 1.5% then I suspect the response will be the same all over again | 12:26 |
| pwr22 | And we'll have a new vaccine in a year | 12:26 |
| pwr22 | Deaths are the only metric that matters to the decision making I think | 12:27 |
| dTal | Yes. Deaths are an easily understood politically relevant statistic. "Percentage of people with nebulously reduced QALYs" isn't. | 12:41 |
| Brainstorm | New from Pfizer: Anonymous: Japan’s MHLW Approves Pfizer’s CIBINQO® (abrocitinib) for Adults and Adolescents with Moderate to Severe Atopic Dermatitis → https://is.gd/WccRwt | 12:56 |
| Estik[m] | Good afternoon. I use an auto-translator, so don't be offended. Tell me, are they discussing the false covid and everything related to it? | 13:03 |
| dTal | Auto-translate may make conversation tricky | 13:17 |
| dTal | What do you mean by "the false covid"? | 13:18 |
| genera | and who is they | 13:20 |
| dTal | genera, I assume "they" is us | 13:21 |
| genera | could be | 13:22 |
| Brainstorm | New from The Indian Express: World: Woman who survived Spanish flu, world war succumbs to Covid → https://is.gd/DgzCIH | 13:28 |
| sdfgsdfg | hey do you guys think a healthy, exercising, strong gentleman 31 years old can survive without the vaccine and not get hospitalized ? | 13:31 |
| genera | in early 2020 when they had that outbreak in Bavaria, they closed the gyms that the employees of a certain company visited. | 13:32 |
| Brainstorm | Updates for Romania: +12032 cases (now 1.2 million), +176 deaths (now 37041), +67976 tests (now 12.9 million) since 22 hours ago | 13:33 |
| sdfgsdfg | a more serious question though... did anyone reading this get covid ???? | 13:38 |
| undefined_bob | sdfgsdfg: most probably yes but there is no guarantee | 13:39 |
| sdfgsdfg | you've never been sick right bob ? | 13:39 |
| undefined_bob | sick from what? | 13:39 |
| sdfgsdfg | covid | 13:39 |
| undefined_bob | hell no | 13:39 |
| Brainstorm | New from EMA: What's new: Medicine: Human medicines European public assessment report (EPAR): COVID-19 Vaccine Janssen, COVID-19 vaccine (Ad26.COV2-S [recombinant]), COVID-19 virus infection, Date of authorisation: 11/03/2021, Revision: 8, Status: Authorised → https://is.gd/leysw6 | 13:40 |
| sdfgsdfg | hmmmm. maybe it doesnt' exist | 13:40 |
| undefined_bob | I wear good masks all the time and I avoid humans as much as possible and keep distance | 13:40 |
| sdfgsdfg | I even hold my breath in the elevator | 13:40 |
| undefined_bob | just wear high quality masks with fit your face well | 13:41 |
| specing | sdfgsdfg: make sure you have loads of vitamin D in your body. Will probably not save you from ICU, but might save you from death | 13:47 |
| sdfgsdfg | there are academic papers on some people naturally being very immune to covid | 13:48 |
| genera | did they try to infect them? | 13:49 |
| genera | or did they just have some antibodies from prior Coronas? | 13:49 |
| sdfgsdfg | they didn't bring the paper to me to peer review I wouldn't know | 13:50 |
| sdfgsdfg | things just pass | 13:50 |
| sdfgsdfg | like emergency powers | 13:50 |
| de-facto | non-vaccinated will have about an order of magnitude or more probability to end up in ICU and grave compared to vaccinated of same age group | 14:02 |
| de-facto | breakthrough infections will have less than half the probability for long covid | 14:03 |
| sdfgsdfg | is there even any research on how cancer patients survival rate is affected if they get the jab | 14:03 |
| de-facto | and even young and healthy can get long covid, many very fit people in sports are affected by that | 14:03 |
| sdfgsdfg | "situation is monitored among cancer patients". Ohhhhh... That's a relief. We can't even accurately predict how long they have left, or whether they are going to survive it | 14:05 |
| sdfgsdfg | Evidence from similar vaccines such as flu vaccinations suggests that the COVID-19 vaccinations are safe and effective for people with cancer. Nor is there any evidence that people with cancer who have the vaccine will experience different or worse potential side effects. | 14:07 |
| sdfgsdfg | quotes from gov websites.... We are clueless | 14:08 |
| de-facto | people with cancer may have damaged or limited immune capabilities, hence depending on the type of cancer and its progression may be in a risk group for COVID fatality hence may profit more than the average person from vaccination against COVID | 14:09 |
| de-facto | interestingly there was an report of one lymphoma patient with remission of his disease by recovering from COVID, so that shows its more complex and would have to be evaluated at individual basis | 14:11 |
| de-facto | probably in his case covid killed the bad cells in lymph system or such | 14:11 |
| sdfgsdfg | in general though I think T-Cells are involved in recognition of these tumors | 14:13 |
| de-facto | btw patients with compromised immune system that are not able to kill off the infection with SARS-CoV-2 may be the breeding ground for new variants of concern such as Kent (B.1.1.7, Alpha) etc | 14:14 |
| de-facto | yes and natural killer cells etc its very complex | 14:14 |
| sdfgsdfg | and lymphoma is an exception, it's misleading, it works around immune system directly, so it makes sense vaxx or covid might affect this positively | 14:14 |
| de-facto | it was one anecdotal report of COVID | 14:14 |
| de-facto | yeah it cant be generalized of course | 14:14 |
| de-facto | i just mentioned it to demonstrate that its quite complex and would need to be evaluated on individual basis | 14:15 |
| dTal | anecdotally, the incidence of covid is much lower among us IRC panickers than among the general population :) | 14:19 |
| undefined_bob | lol yes, I would agree with that | 14:19 |
| de-facto | .title https://link.springer.com/article/10.1007%2Fs10654-020-00698-1 meaning ifr[age_] := (2^(age/5.74))/ 186209 or 1/ifr[31] ~ 4408 with the 2020 variants, so now its probably already double or more of that fatality, so for non-vaccinated maybe 1 in 2000 or such? | 14:25 |
| Brainstorm | de-facto: From link.springer.com: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications | SpringerLink | 14:25 |
| de-facto | dTal, well yeah unless the reason for joining is contamination | 14:26 |
| Brainstorm | Updates for Brunei: +3 deaths (now 43), +5575 tests (now 355811) since a day ago — Switzerland: +968 cases (now 839219), +73067 tests (now 10.8 million) since 23 hours ago | 14:35 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In today's @nytimes The remarkable work of Drs @PeterHotez and @mebottazzi to help achieve global vaccination @TexasChildrens 🙏👋👋 pic.twitter.com/xTnd9o4Rbh → https://is.gd/HoihYE | 14:55 |
| Brainstorm | Updates for Denmark: +2 deaths (now 2656), +141696 tests (now 83.7 million) since 23 hours ago | 15:00 |
| sdfgsdfg | only 2 deaths in denmark ? nice | 15:30 |
| sdfgsdfg | evolution must have blessed vikings with something against flu-like diseases right | 15:34 |
| Brainstorm | Updates for Belarus: +15 deaths (now 4129), +36760 tests (now 8.5 million) since 23 hours ago | 15:37 |
| Brainstorm | New from The Indian Express (Health): Health: Can vitamin A nasal drops help restore Covid loss of smell? Know what experts say → https://is.gd/zVfrmS | 15:39 |
| undefined_bob | https://www.nature.com/articles/s41579-021-00642-4 | 15:40 |
| undefined_bob | "Influenza lineage extinction during the COVID-19 pandemic?" | 15:41 |
| de-facto | http://offloop.net/covid19/?default=Germany;Denmark&byPopulation=yes&cumulative=no&smooth=yes&leftTrim=500 | 15:41 |
| undefined_bob | sdfgsdfg: and no, many people have died in denmark already | 15:41 |
| de-facto | Germany got double as high fatality rates, but denmark is increasing | 15:41 |
| de-facto | well both countries are increasing | 15:42 |
| undefined_bob | but in one hour I can finally go home :) | 15:43 |
| Estik[m] | <sdfgsdfg> "hey do you guys think a healthy,..." <- I think I need to go to the village. Only there you can be saved. | 15:45 |
| sdfgsdfg | alright alright I'll go get vaccinated | 15:46 |
| de-facto | i rather like to live in a city with good hospital capacity | 15:47 |
| de-facto | than living in a remote village | 15:47 |
| undefined_bob | but in remote village less people who can harm you and a helicopter will be there quickly too | 15:48 |
| sdfgsdfg | you wont have to worry unless youre 40+ years old | 15:48 |
| undefined_bob | no | 15:48 |
| Estik[m] | sdfgsdfg: Why are you tired of living? | 15:48 |
| sdfgsdfg | 2 years in lockdown is not living lol | 15:49 |
| de-facto | vaccination is as close as you can get to pre-pandemic, its the best we currently have | 15:50 |
| de-facto | last year incidence began to rise in October in Germany | 15:51 |
| Estik[m] | sdfgsdfg: What a pity my friends that I can not show you content that is not in English. Where our president says that it has long been possible to edit DNA. | 15:52 |
| sdfgsdfg | my ex caught the virus and she was still partying like a ho, 30 yrs old | 15:53 |
| de-facto | .title https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00299-6/fulltext | 15:55 |
| Brainstorm | de-facto: From www.thelancet.com: Characterizing long COVID in an international cohort: 7 months of symptoms and their impact - EClinicalMedicine | 15:55 |
| de-facto | .title https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003773 | 15:56 |
| Brainstorm | de-facto: From journals.plos.org: Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19 | 15:56 |
| specing | sdfgsdfg: look, if you don't want to get vaccinated then don't | 15:56 |
| specing | and you don't really have to follow lockdown rules for the most part. Simply because the likelyhood of being caught is low | 15:56 |
| sdfgsdfg | it either gets better or worse, I'll just isolate | 15:57 |
| de-facto | you cant isolate forever, you can just lower the probability to catch it | 15:58 |
| sdfgsdfg | haha, most of us here are familiar with isolation, it's our comfort zone | 15:58 |
| de-facto | unfortunately it was decided that SARS-CoV-2 will stay, hence sooner or later we all will be exposed to that damn thing | 15:58 |
| undefined_bob | de-facto: one just have to be careful? | 15:59 |
| de-facto | and imho its best to prepare for impact with the best methods we currently have, hence vaccination and healthy livestyle | 15:59 |
| undefined_bob | like continue to wear mask and keep distance and so on | 15:59 |
| undefined_bob | I dont wanna get it :( | 16:00 |
| sdfgsdfg | get vaccinated every 4 months then | 16:00 |
| de-facto | neither do any of us, but better to get exposed with a non-naive immune system than being among those with the highest risk of that age group | 16:01 |
| Brainstorm | New from Reddit (test): China_Flu: People with natural immunity and subsequent mRNA vaccination can neutralize viral particles capable of resisting vaccine-induced antibodies → https://is.gd/DL9POI | 16:01 |
| Brainstorm | Updates for Nepal: +898 cases (now 795061), +12 deaths (now 11135) since a day ago | 16:02 |
| specing | sdfgsdfg: yep, planning to do just that | 16:13 |
| de-facto | imho its a good idea to get vaccinated now to prepare for the winter, because not only will reproduction increase about 40% because of seasonality, also containment measures will be less because of so many vaccinated already | 16:18 |
| de-facto | that means the reported incidence is concentrated on a non-vaccinated minority hence much much higher among those than the reported averaged incidence for all citizens (both vaccinated and non-vaccinated) | 16:20 |
| de-facto | and still despite the majority being vaccinated already the majority of hospitalized is not vaccinated, meaning the protection seems to work pretty well so far | 16:21 |
| Brainstorm | New from Contagion Live: STIs and Usage of PrEP During the COVID-19 Pandemic: Rates of Sexually Transmitted Infections (STIs) and engagement in HIV pre-exposure prophylaxis during the COVID-19 pandemic were previously unknown, but one IDWeek study examined these data trends over the past few years. → https://is.gd/xs6Wkt | 16:23 |
| de-facto | oh wow RKI got a new dashboard for COVID data | 16:24 |
| de-facto | .title https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/COVID-19-Trends/COVID-19-Trends.html?__blob=publicationFile#/home | 16:24 |
| Brainstorm | de-facto: From www.rki.de: Covid-19-Trends in Deutschland im Überblick | 16:24 |
| Estik[m] | I will say this, I myself have been ill. Alive and healthy. And the vaccine has encoded DNA, which is inherited. What did they put there? Only God knows! | 16:25 |
| de-facto | that looks really nicely done | 16:25 |
| de-facto | Estik[m] that info is false, the vaccine does NOT contain encoded DNA and it is destroyed within days, nothing will change your DNA from the vaccine | 16:26 |
| undefined_bob | Estik[m]: thats false | 16:26 |
| qkall[m] | de-facto: doing gods work out here today | 16:26 |
| de-facto | none of the mRNA or vector vaccines would do such a thing, it was discussed many many times already | 16:26 |
| de-facto | the vaccines contain the recipe to produce the spikes of the coronavirus, those get exposed on the cells surface and the immune system develops immunity against those spikes hence learns to also neutralize the real virus | 16:28 |
| de-facto | that recipe is encoded either in mRNA or DNA plasmids, those are very short lived and get destroyed quite quickly in the cells, there is no residual left from that | 16:29 |
| Estik[m] | undefined_bob: Sputnik V and the like contain one hundred percent! There is proof. | 16:29 |
| de-facto | Sputnik V is a adenovirus vector vaccine (just as AstraZeneca and Janssen) | 16:30 |
| undefined_bob | this lol | 16:30 |
| Estik[m] | ACTION uploaded a video: (27639KiB) < | 16:31 |
| Estik[m] | https://libera.ems.host/_matrix/media/r0/download/matrix.org/KtbSsAiEOnKlbvqlpvcqkeMz/%D0%93%D0%98%D0%9D%D0%A6%D0%91%D0%A3%D0%A0%D0%93_%20%C2%AB%D0%A1%20%D0%9F%D0%9E%D0%9C%D0%9E%D0%A9%D0%AC%D0%AE%20%D0%92A%D0%9A%D0%A6%D0%98%D0%9D%20%D0%9B%D0%AE%D0%94%D0%AF%D0%9C%20%D0%92%D0%92%D0%9E%D0%94%D0%AF%D0%A2%20%D0%9D%D0%95%20%D0%91%D0%95%D0%9B%D0%9E%D0%9A%2C%20%D0%90%20%D0%93%D0%95%D0%9D%2C%20%D0%9A%D0%9E%D0%A2%D0%9E%D0%A0%D0%AB%D0%99%20%D0%9A%D0%9E | 16:31 |
| Estik[m] | %D0%94%D0%98%D0%A0%D0%A3%D0%95%D0%A2%D0%A1%D0%AF%C2%BB.mp4 > | 16:31 |
| de-facto | it uses replication-deficient adenovirus particles at transport vectors for a DNA plasmid that encodes the recipe to produce the spike protein, it gets translated to mRNA that gets transcribed into s-protein, neither the DNA plasmid nor the mRNA would get integrated in the cells DNA | 16:31 |
| de-facto | it is not gene editing or anything like that, please inform yourself before spreading such false info | 16:33 |
| de-facto | its the natural way of cells to produce proteins | 16:34 |
| de-facto | btw exactly that mechanism is also hijacked by any virus to reproduce itself | 16:34 |
| de-facto | exactly that happens all the time in cells | 16:35 |
| Estik[m] | You may be right. But I would not trust my non-WHO government. As our prizidet said such technologies have been available for a long time. And they will soon be implemented. | 16:37 |
| de-facto | what matters is what is encoded in the mRNA, its the recipe to build proteins, it can be used to encode almost anything, a virus encodes his own build-recipe, the vaccines just that small part, the s-protein of SARS-CoV-2 | 16:37 |
| qkall[m] | don't trust anyone other than the peer reviewed process of globally sourced data. it's teh best vetting process we have. | 16:38 |
| de-facto | its a bit like a computer program: it can encode good and useful things, but also bad things like viruses etc | 16:38 |
| de-facto | yes i agree, but those vaccines have been independently reserve engineered | 16:38 |
| de-facto | .title https://github.com/NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273 | 16:39 |
| Brainstorm | de-facto: From github.com: GitHub - NAalytics/Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273: RNA vaccines have become a key tool in moving forward through the challenges [...] | 16:39 |
| de-facto | one example of reversing the vaccine code | 16:39 |
| Brainstorm | Updates for Qatar: +85 cases (now 236643), +1 deaths (now 606), +6069 tests (now 2.7 million) since a day ago — Germany: +7322 cases (now 4.2 million) since 23 hours ago — Faroe Is.: +17 cases (now 1178), +2000 tests (now 431000) since 22 hours ago | 16:39 |
| Estik[m] | I don't have time to translate for you. And answer. We'll do it another time. Goodbye.🙂 | 16:45 |
| de-facto | .title https://berthub.eu/articles/posts/reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ | 16:45 |
| Brainstorm | de-facto: From berthub.eu: Reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine - Bert Hubert's writings | 16:45 |
| de-facto | .title https://berthub.eu/articles/posts/part-2-reverse-engineering-source-code-of-the-biontech-pfizer-vaccine/ | 16:46 |
| Brainstorm | de-facto: From berthub.eu: Reverse Engineering Source Code of the Biontech Pfizer Vaccine: Part 2 - Bert Hubert's writings | 16:46 |
| de-facto | .title https://berthub.eu/articles/posts/curevac-vaccine-and-wonders-of-biology/ | 16:47 |
| Brainstorm | de-facto: From berthub.eu: The CureVac Vaccine, and a brief tour through some of the wonders of nature - Bert Hubert's writings | 16:47 |
| de-facto | .title https://berthub.eu/articles/posts/genetic-code-of-covid-19-vaccines/ | 16:47 |
| Brainstorm | de-facto: From berthub.eu: The Genetic Code and Proteins of the Other Covid-19 Vaccines - Bert Hubert's writings | 16:47 |
| de-facto | that new dashboard for Germany from RKI is really nice it even allows trends per age group display options, that is really helpful https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/COVID-19-Trends/COVID-19-Trends.html?__blob=publicationFile#/home | 16:58 |
| de-facto | oh and they have a difference with days of previous week, that shows if there is an increase/decrease relative for each day of previous week | 17:02 |
| de-facto | unfortunately it seems the decrease is over and we may transition into an increase again | 17:03 |
| lastshell | what language is it the video ? | 17:07 |
| Brainstorm | New from EMA: What's new: General: Guidance for medicine developers and other stakeholders on COVID-19 → https://is.gd/bb9aBG | 17:27 |
| MerlinMp[m] | <sdfgsdfg> "you wont have to worry unless..." <- Im 40+ and had covid some time ago (probably alpha variant) | 17:36 |
| Brainstorm | New from LitCovid: (news): How Life Can Return to Normal: Ending the COVID-19 Pandemic. → https://is.gd/ksD61H | 17:50 |
| Brainstorm | New from WebMD: A Pill to Treat COVID Could Be Just Months Away: At least three promising antiviral treatments for covid-19 are being tested in clinical trials, with results expected as soon as late fall or winter. → https://is.gd/l2rX2R | 18:01 |
| Brainstorm | Updates for United Kingdom: +23827 cases (now 7.8 million), +1175835 tests (now 303.4 million) since 15 hours ago — Greece: +2232 cases (now 655767), +33 deaths (now 14828), +150433 tests (now 20.1 million) since 23 hours ago — Jordan: +1027 cases (now 823919), +8 deaths (now 10718), +31384 tests (now 10.1 million) since 21 hours ago [... want %more?] | 18:31 |
| LjL | oh bleh | 18:40 |
| LjL | i repeatedly noticed the extremely high testing numbers there above in the UK, and thought, sure they have more cases, but they also have about 4x italy's tests (around 300k on the best days) | 18:41 |
| LjL | but then turns out the vast majority are "pillar 3" tests https://coronavirus.data.gov.uk/details/testing which means neither PCR nor rapid, but antibody tests | 18:41 |
| LjL | wait no i'm wrong | 18:42 |
| LjL | ignore me | 18:42 |
| LjL | so yeah they actually do test about 4x as much as Italy, unless i should be ignored again | 18:43 |
| Brainstorm | New from COVID tweets: Rio Slade lives on land stolen from the Mvskoke (@RioSlade): When the Immune Response Makes COVID-19 WorseIf the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.the-scientist.com/news-opinion/w… pic.twitter.com/LwFDQ61epC → https://is.gd/k3EMFZ | 18:56 |
| Brainstorm | Updates for Greenland: +3 cases (now 576), +1090 tests (now 75813) since a day ago | 19:08 |
| de-facto | LjL, but then positivity rate in UK is 3.5% (possibly saturating or rising) and in Italy its only 1.2% (and potentially falling) according to https://ourworldindata.org/grapher/positive-rate-daily-smoothed | 19:17 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Amherst school district to require student COVID-19 vaccines; that has full federal approval by Dec. 1 to continue attending classes. Medical and religious exemptions are allowed. → https://is.gd/3X79KE | 19:19 |
| LjL | de-facto: I know, but our testing remains ridiculous, considering 300k a day is more or less the maximum we *ever* reached, even when we had high rates (but to be fair, back then they were all PCR, now among the 300k, most are rapid antigen, which bring the rate way down) | 19:19 |
| de-facto | hmm everywhere in Europe positivity seems to be much lower, just stupid old Germany got 7.5% :/ | 19:20 |
| de-facto | well maybe preselected with rapid tests, i think those are all confirmed via PCR later | 19:20 |
| zutt | hmh, government lifted mask recommendation today in Finland :F | 19:21 |
| zutt | I'm not sure how I feel about that yet | 19:22 |
| de-facto | zutt, how are vaccinations progressing in Finland? | 19:24 |
| LjL | de-facto: if the rapid tests are positive... But as you know rapid tests have a ton of false negatives. So it's not meaningful to compare a time when we had 300k PCR a day with one when we have (just guessing now, I don't have the numbers in front of me anymore) 200k rapid and 100k PCR. I can tell you how much the actual *PCR* positive rate is, hold on... It's going to be relatively low still, but definitely higher than 1% | 19:25 |
| zutt | quite well, ~80% of over 12 year olds have received at least one vaccination | 19:25 |
| de-facto | that sounds very good actually | 19:26 |
| LjL | Actually, hold on until I'm home, doesn't look like I can see the graphs separately on mobile :p | 19:28 |
| de-facto | afaik RKI targets 85% 12-59 and 90% for over 60 year olds to be vaccinated for Delta VoC | 19:29 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The relationship of #SARSCoV2 genomic variant (by sequencing), risk of hospitalization, and reduction by vaccinationmedrxiv.org/content/10.110…Beta, Gamma, and Delta infections all increase risk of hospitalizationVaccination reduces that risk across all major variants@paredesmig pic.twitter.com/WPyrZSrdFw → https://is.gd/K37tfZ | 19:30 |
| de-facto | LjL, yeah rapid antigen tests and pcr should be compared each in own category, afaik only rapid antigen tests found only 2 out of 5 PCR positive or such | 19:30 |
| de-facto | .title https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00248-6/fulltext | 19:32 |
| Brainstorm | de-facto: From www.thelancet.com: Clinical performance evaluation of SARS-CoV-2 rapid antigen testing in point of care usage in comparison to RT-qPCR - EBioMedicine | 19:32 |
| de-facto | "The sensitivity of RDT compared to RT-qPCR was 42·57% (95% CI 33·38%–52·31%). The specificity was 99·68% (95% CI 99·48%–99·80%). Sensitivity declined with decreasing viral load from 100% in samples with a deduced viral load of ≥10^8 SARS-CoV-2 RNA copies per ml to 8·82% in samples with a viral load lower than 10^4 SARS-CoV-2 RNA copies per ml." | 19:32 |
| de-facto | of course depending on the actual tests in use, but i would guess the technologies still perform similar to those as PCR got the advantage of having amplification of the signal while RDT needs higher loads (hence later detection) of viral loads | 19:36 |
| LjL | de-facto, today, PCR: 2.42%, antigen: 0.13%. at the latest peak (August), PCR: 9.80%, antigen: 0.36% | 19:37 |
| LjL | the difference is striking to say the least | 19:37 |
| de-facto | well but probably antigen is more often done "without suspicion" than PCR | 19:38 |
| de-facto | just because its cheaper | 19:38 |
| de-facto | and faster | 19:38 |
| de-facto | and has to be done more often due to lower sensitivity anyhow | 19:38 |
| de-facto | LjL, out of curiosity, do you know what those cost in Italy? RDT and PCR? | 19:38 |
| de-facto | Antigen rapid diagnostic tests (RDT) | 19:39 |
| de-facto | here in Germany people will have to pay for the tests themselves soon, i guess that means we will see LOT less cases | 19:42 |
| de-facto | from 11th of October | 19:42 |
| de-facto | .tr <de die Preise für Antigen-Schnelltests zwischen 18 und 40 Euro, PCR-Tests können sogar über 130 Euro kosten | 19:43 |
| Brainstorm | de-facto, German to English: the prices for rapid antigen tests between 18 and 40 euros, PCR tests can even cost over 130 euros (MyMemory, Google) | 19:43 |
| de-facto | .tr <de Laut Bundesgesundheitsministerium (BMG) können die Preise mithilfe der bestehenden Vergütungshöhen geschätzt werden. Der Bund erstattet bisher 11,50 EUR für Schnelltests und 43,56 EUR für PCR-Tests. | 19:43 |
| Brainstorm | de-facto, German to English: According to the Federal Ministry of Health (BMG), the prices can be estimated using the existing reimbursement levels. So far, the federal government has reimbursed EUR 11.50 for rapid tests and EUR 43.56 for PCR tests. (MyMemory, Google) | 19:43 |
| de-facto | .tr <de Ab dem 11. Oktober 2021 müssen viele Ungeimpfte für ihre Corona-Tests dann aber tief in die eigene Tasche greifen. Kostenlos sind die Corona-Tests dann nämlich nur noch für die Personen, die sich nicht impfen lassen können, weil für sie keine allgemeine Impfempfehlung besteht | 19:44 |
| Brainstorm | de-facto, German to English: From October 11, 2021, many unvaccinated people will have to dig deep into their own pockets for their corona tests. The corona tests are then only free of charge for people who cannot be vaccinated because there is no general vaccination recommendation for them (MyMemory, Google) | 19:44 |
| de-facto | from https://www.fr.de/panorama/corona-test-schnelltest-ungeimpft-kosten-preis-teuer-coronavirus-pandemie-teststation-ltt-91022898.html | 19:44 |
| de-facto | btw in supermarket the rapid antigen tests can be bought for 1€ or less per test, but samples have to be taken in a do-it-yourself approach, so potentially not as well as in testing stations or GPs | 19:46 |
| de-facto | anyhow imho its a stupid and completely wrong approach to artificially ramp down testing at the begin of the winter wave in October | 19:47 |
| de-facto | because it will lead to less people being aware of being currently infectious, hence happily spreading it around | 19:47 |
| LjL | de-facto, i think for workers needing a green pass, the price of rapid test has been fixed to €15. someone else said here it's €22 generally, not sure. this is about antigen tests administered by a pharmacist (i don't know about the self-administered ones, but those don't end up in the daily counts anyway). PCR is probably free but requiring a medical prescription | 19:48 |
| de-facto | yeah so pretty similar in prices then | 19:49 |
| LjL | i just don't really know if we have cheap self-administered ones. Amazon sells them but they are not cheap at all (not €1 at least, more like €15-20) | 19:49 |
| LjL | but again that's irrelevant to the stats | 19:50 |
| de-facto | imho the strategy should be to motivate more people to get tested, just to end more infection chains, yet it seems the exact opposite of that is currently implemented right now | 19:50 |
| de-facto | honestly i dont understand why | 19:50 |
| de-facto | it does not make any sense to me, case numbers are just going to be much less reliable | 19:50 |
| goodtothebone | dont get the antigen treatment , side effects for that is the swelling for the brain | 19:51 |
| de-facto | and reproduction will go up, in addition to seasonal effects | 19:51 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19 Breakthrough Infections in Vaccinated Health Care Workers | NEJM → https://is.gd/KAeoYW | 19:51 |
| de-facto | .title https://theconversation.com/preliminary-research-finds-that-even-mild-cases-of-covid-19-leave-a-mark-on-the-brain-but-its-not-yet-clear-how-long-it-lasts-166145 | 19:52 |
| Brainstorm | de-facto: From theconversation.com: Preliminary research finds that even mild cases of COVID-19 leave a mark on the brain – but it's not yet clear how long it lasts | 19:52 |
| de-facto | yeah COVID can damage the brain it seems, another reason to get vaccinated hence avoid being exposed to it with a naive immune system | 19:53 |
| de-facto | hmm maybe they deliberately want to make case numbers unreliable by preventing people to go for a test by making them pay for it themselves and dont support quarantine anymore just to enforce the only metric that delivers somewhat reliable results are hospitalizations and fatalities | 19:59 |
| de-facto | but that means we are basically blind for any breakthrough waves burning through the vaccinated, we only would notice those too late then | 19:59 |
| de-facto | its time for this government to go away and be replaced with a better one | 20:00 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): We're at 56% US total population fully vaccinated.We need to get to at least 75% to achieve containment, as has been determined by at least 12 countries (w/ caveats and contingencies)news.yahoo.com/what-is-bidens…by @alexnazaryan @YahooNews pic.twitter.com/E4U2nPyZdz → https://is.gd/Eafo7z | 20:02 |
| de-facto | oh US expectations are lower than RKIs then | 20:03 |
| Brainstorm | New from Contagion Live: us: Racial, Ethnic Disparities in COVID-19 Incidence in People Living With HIV → https://is.gd/0NWu50 | 20:23 |
| Brainstorm | Updates for Spain: +2400 cases (now 5.0 million), +18 deaths (now 86415) since 23 hours ago — Canada: +63 deaths (now 27840) since 22 hours ago | 20:29 |
| Brainstorm | New from r/Science: science: Scientists at Stanford University and the University of North Carolina have developed a 3D printed vaccine patch. The new 3D printed vaccine patch offers greater protection than jabs. → https://is.gd/eZBniV | 20:45 |
| de-facto | .title https://www.researchsquare.com/article/rs-951263/v1 | 21:02 |
| Brainstorm | de-facto: From www.researchsquare.com: Comparison of fourteen Rapid Point-of-Care Antigen Tests for SARS-CoV-2: Use & Sensitivity | Research Square | 21:02 |
| Brainstorm | New from CIDRAP: News Scan for Sep 30, 2021: ECMO and COVID death Breakthrough COVID-19 in Scotland Wearable sensors for flu, colds H5N6 avian flu cases in China CWD testing incentive in Louisiana Illinois rabies death → https://is.gd/7SMNn0 | 21:18 |
| nixonix | .title https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19infectionsurveytechnicalarticle/analysisofpopulationsintheukbyriskoftestingpositiveforcovid19september2021 | 22:00 |
| Brainstorm | nixonix: From www.ons.gov.uk: Coronavirus (COVID-19) Infection Survey technical article - Office for National Statistics | 22:00 |
| nixonix | .title https://twitter.com/DrEricDing/status/1443411199920594956 | 22:01 |
| Brainstorm | nixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "⚠️NATURAL IMMUNITY versus VACCINES—Which is stronger? Let’s compare reinfection breakthroughs vs vaccine breakthroughs: ➡️Natural immunity is **MUCH weaker than [...] | 22:01 |
| nixonix | lots of caveats, as usual. not age stratified, or adjusted per region etc, or by time since 2nd dose or infection | 22:05 |
| nixonix | younger are more likely skip vaccination, have more risky behavior, are more often urban where delta prob came earlier (notice the difference reduced after the first two months, when delta likely reached rural regions and small towns) | 22:07 |
| nixonix | lets compare how long since infection or 2nd dose: end date was septemper 20. i checked us total identified cases on that date, took half of it, and that total identified case number was reached january 4th, so half got infected befor dec 31 2020 | 22:15 |
| lastshell | I'm not sure to laugh or cry https://www.youtube.com/watch?v=2S2v45_NSYs | 22:15 |
| de-facto | hm on that comparison of vaccine vs natural immunity i miss a date on immunity, e.g. how long was recovery or completion of vaccination gone after breakthrough/reinfection? | 22:17 |
| lastshell | I guess depends of how bad was the infection ? | 22:17 |
| de-facto | and how long ago | 22:18 |
| de-facto | not only because of antigenic drift but also because of waning | 22:18 |
| de-facto | immunity fading away | 22:18 |
| lastshell | does antibodies also drop for natural infection ? | 22:18 |
| nixonix | for vaccinated, half got their 2nd dose before apr 23 2021. so theres roughly 4.5 months more time on average since unvaccinated's primary infection. sure for some of them it wasnt the first on, which improved their protection, but also some vaccinated had infection before | 22:19 |
| de-facto | UKs big wave was from Sept 2020 till March 2021 | 22:21 |
| de-facto | so probably most naturally immunized got their infection in that timewindow | 22:21 |
| nixonix | so for the last month, septemper, in that oklahoma data vaccinated had around 4.5 months since the 2nd dose, and unvaccinated roughly 9 months since their primary infection, on average | 22:21 |
| de-facto | https://www.worldometers.info/coronavirus/country/south-korea/%20https://www.worldometers.info/coronavirus/country/uk/ | 22:21 |
| nixonix | really hard to say if vaccinated really had better protection vs identified infection or not in oklahoma. but vaccination beats "natural infection" for sure, because you dont have to get infection without protection from adaptive immune response | 22:24 |
| de-facto | most vaccination doses in UK were given between mid of Jan till begin of July https://ourworldindata.org/grapher/daily-covid-vaccination-doses-per-capita?country=~GBR | 22:24 |
| nixonix | that idea of natural infection without protection is just crazy. now antivaxers try to sell it using that flawed israeli study, and "protection" from ivermectin | 22:25 |
| de-facto | oh that is not UK data? | 22:25 |
| lastshell | nixonix ivermectin is still in high demand in us | 22:26 |
| lastshell | even if is not fda approved | 22:26 |
| nixonix | no, oklahoma | 22:26 |
| de-facto | argh forget my links then | 22:26 |
| nixonix | that one in erics tweet above | 22:26 |
| de-facto | yeah | 22:26 |
| nixonix | anyways, with my rough guess, using above adjustments and some estimation, during may-june vaccination beat "natural infection" protection clearly, but after that when vax was waned, it was probably close | 22:28 |
| lastshell | Jc post other video about Aspiration (for the injection) https://www.youtube.com/watch?v=KgVsd6qoyU4 | 22:28 |
| nixonix | should have used oklahoma's infections and vaccinations instead of their national... but prob doesnt change much, that raw data is just too messy to get any accurate estimations | 22:28 |
| de-facto | Oklahoma infections between early Sept and March https://www.worldometers.info/coronavirus/usa/oklahoma/ vaccinations early Feb till early May or such https://ourworldindata.org/grapher/us-daily-covid-vaccine-doses-per-100?country=~Oklahoma | 22:31 |
| nixonix | two days earlier for half of total infections, jan 2 (and infected in the end of dec). for vaccinations, i dont bother to check, its prob very close to national vax rate anyway | 22:31 |
| nixonix | looks like mrna (mostly) vaxes with 3/4 week interval gives only around 3 months good protection vs identified infection with delta, from that oklahoma data. which is consistent with my earlier observations from qatar, israel etc | 22:34 |
| de-facto | hopefully more with 6 weeks | 22:35 |
| nixonix | that ons data, see how bad az is vs identified cases. munro tried to play it down in twitter | 22:36 |
| nixonix | .title https://twitter.com/MarvinH2_G2/status/1443548488973889537 | 22:36 |
| Brainstorm | nixonix: From twitter.com: Marvin (@MarvinH2_G2): "Should boost with the Pfizer vaccine and ditch the duff one with the UnionJack on it. Worried about Pollard on JCVI's comments which didn't distinguish between AZ and Pfizer - [...] | 22:36 |
| de-facto | hmm look at the slopes of those curves | 22:38 |
| de-facto | thats interesting | 22:38 |
| de-facto | https://pbs.twimg.com/media/FAhU1fzWEAUD7Mz?format=jpg&name=large | 22:39 |
| nixonix | might be other reasons than about immunity. behavioral, restrictions, waves etc. sure if they dont sync with other vaccine it might tell about difference of several components of immunity, but it could also be because different age and other groups were used az vs pfizer | 22:40 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.09.28.21264260v1 | 22:41 |
| Brainstorm | de-facto: From www.medrxiv.org: The impact of SARS-CoV-2 vaccination on Alpha and Delta variant transmission | medRxiv | 22:41 |
| de-facto | page 23 | 22:41 |
| nixonix | on those they went in sync, but i think some curves werent, if i recall | 22:41 |
| nixonix | no, it was just those last curve, delta vs alpha (not vax vs vax) | 22:43 |
| nixonix | btw because vax vs vax curves behaved so similarly, that hints that killer t-cells didnt have much effect on identified cases, because apparently az has stronger killer t-cell response | 22:45 |
| Brainstorm | New from Contagion Live: How COVID-19 Impacted HIV Testing in the Emergency Department: In a study looking at one urban South Florida hospital, the pandemic negatively impacted testing. → https://is.gd/tkm9au | 22:46 |
| nixonix | how about ct values vs pcr-positive, the last curves, what does that tell about share of unviable virions, delta vs alpha? | 22:49 |
| nixonix | when my assumption was, because over 1000x higher viral loads with delta (vs alpha, wasnt it), there would be higher share of unviable virions with delta, so the actual difference would prob be smaller | 22:50 |
| nixonix | and i think some study showed it was, like i guessed, somewhere between 10-100x | 22:50 |
| de-facto | it was 1000 fold against 2020 variants, so probably B.1 or such | 22:51 |
| nixonix | ok | 22:51 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.07.07.21260122v2 | 22:52 |
| Brainstorm | de-facto: From www.medrxiv.org: Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant | medRxiv | 22:52 |
| de-facto | "Daily sequential PCR testing of the quarantined subjects indicated that the viral loads of Delta infections, when they first become PCR+, were on average ∼1000 times greater compared to A/B lineage infections during initial epidemic wave in China in early 2020, suggesting potentially faster viral replication and greater infectiousness of Delta during early infection." | 22:53 |
| de-facto | so maybe even pre B.1 | 22:53 |
| de-facto | is that without D614G? | 22:53 |
| nixonix | but from that last curve set, it looks like if similar viral loads they infect as much, but with lower viral loads, delta infects more efficiently (sure actually delta has higher viral loads, so it infects more on average) | 22:53 |
| de-facto | yeah its compared to the very earliest cases in China | 22:54 |
| nixonix | in the spring 2020 it varied by area, if it was mostly 614D or 614G. then 614G replaced it, but it took some time (maybe 20-25% transmission advantage only) | 22:54 |
| nixonix | i think china was mostly D. was it ever found out, where 614G likely emerged? | 22:55 |
| de-facto | first seen in north of italy afaik | 22:55 |
| nixonix | yeah but it was hidden early on, so were there other areas that werent much in contact with italy, that had 614G early on | 22:56 |
| nixonix | usa was mixed, west coast got it mostly from china, east coast mostly from europe | 22:57 |
| nixonix | lots of europe got it from austria mostly, i think | 22:58 |
| nixonix | cant remember what were A and B lineage differencies | 23:00 |
| nixonix | The Indian Council of Medical Research (ICMR) and the National Task Force on Covid-19 have dropped the use of Ivermectin and Hydroxychloroquine (HCQ) drugs from their revised guidelines for the treatment of the infection. The decision was taken after experts found that these drugs have little to no effect on Covid-related mortality or clinical | 23:01 |
| nixonix | recovery of the patient. | 23:01 |
| de-facto | yeah its hard to tell because it does not really migrate slowly but jumps rapidly around globally via fast airplane travel | 23:02 |
| nixonix | .title https://www.indiatoday.in/coronavirus-outbreak/story/why-hcq-ivermectin-dropped-india-covid-treatment-protocol-1857306-2021-09-26 4 days old | 23:02 |
| Brainstorm | nixonix: From www.indiatoday.in: Why HCQ and Ivermectin were removed from India’s Covid-19 treatment protocol - Coronavirus Outbreak News | 23:02 |
| de-facto | if it was first seen in north italy, how can we know it was not introduced a day before by some tourist from any other location of the world | 23:02 |
| nixonix | btw, i think delta is somewhat less superspreader driven, because with delta larger share of people produces particle clouds that are dense enough to infect several, if they are at the same premises. so superspreaders "advantage" to produce dense clouds, more is "wasted" when not enough people around, or air just doesnt propagate efficiently enough | 23:05 |
| nixonix | in large premises | 23:05 |
| de-facto | hmm is something saturated? are all infected in a room? or is viral shedding of super spreaders saturated? | 23:06 |
| Brainstorm | New from Contagion Live: Discontinuing Precautions in Asymptomatic, PCR-Positive COVID-19 Patients: A survey found most healthcare professionals would clear an asymptomatic patient with a positive PCR test if the patient met other criteria. → https://is.gd/PLVhvI | 23:07 |
| nixonix | also if there is particle cloud when you are inside somewhere, its more often dense enough to pass any masks, excluding PAPR. so bad masks with lots of side flow are even less usefull, because those marginal situations where they might help, are more rare | 23:07 |
| nixonix | but its most likely about initial viral dose, if your innate immunity beats it or not, because if you get only small number of virions, exponential growth takes time to get the numbers up - and the same with expanding nk cells (and those with some immunity, abs present in upper resp tract) | 23:10 |
| nixonix | so while even the best FFP3 mask tight so that your eyes bulge out doesnt probably stop it, because cloud densities are often very high, it gives more time before they multiply to high numbers | 23:12 |
| nixonix | saturated in some area (to high enough numbers to likely infect), but it depends on airflow what area that would be | 23:13 |
| nixonix | better avoid places near exhaust vents, back of bus etc, imo | 23:14 |
| nixonix | and try to keep the time inside as short as possible. quick shopping | 23:15 |
| de-facto | someone i know does a nasal shower (0.9% salty water) with povidone-iodine to kill the germs | 23:18 |
| de-facto | in case he feels like getting a cold or such | 23:18 |
| nixonix | doesnt your mucosa get damaged so that infection would be more likely? | 23:19 |
| de-facto | i am not sure, i think povidione-iodine at low concentrations is somewhat tolerable for some limited amount of time | 23:19 |
| nixonix | yeah. i remember some studies found some stuff like that useful. maybe | 23:20 |
| de-facto | out of curiosity i tried 250ml 0.9% NaCl solution in water with 4 drops of povidione-iodine every 8h for 4 days without any bad effects | 23:20 |
| de-facto | i did not had any cold, just experimentation, so i cant tell if it also affects immune cells on the mucus surface | 23:21 |
| de-facto | i asked my throat-nasal-ears specialist MD and she said, yeah it does not hurt the mucus | 23:21 |
| de-facto | if it helps against COVID? i dont have a clue actually | 23:22 |
| de-facto | btw i would never do that with alcohol or any other substance | 23:22 |
| nixonix | .title https://link.springer.com/article/10.1007/s00405-021-06644-5 | 23:24 |
| Brainstorm | nixonix: From link.springer.com: A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene | SpringerLink | 23:24 |
| nixonix | and there was some common sniffles spray, i think some study found it to work reducing viral load or something. cant remember what they used (i have combo with two affecting components, just for sniffles) | 23:26 |
| Brainstorm | New from Contagion Live: Early 3-Day Remdesivir Regimen Reduces COVID-19 Hospitalization, Death by 87%: The study author of the late-breaking IDWeek findings discusses what the new data mean for using the antiviral to reduce COVID-19 burden. → https://is.gd/5SJiij | 23:28 |
| de-facto | oh btw the manufacturer says "NO it was not shown to help" https://betadine.com/covid-19/ | 23:30 |
| de-facto | "Betadine Antiseptic products have not been demonstrated to be effective for the treatment or prevention of COVID- 19 or any other viruses." | 23:31 |
| de-facto | although some papers showed that it may be able to reduce viral loads a bit | 23:31 |
| nixonix | Ipratropium bromide - this is the component needed for runny nose (use only couple of the worst days, or it might make it stuffy) | 23:32 |
| nixonix | so with that prob less damaged mucosa too, and less hampered innate response, that healthy mucous membrane is part of | 23:33 |
| nixonix | interferon spray would be good, if you get it early enough. but should be during the first few hours after infection. or used as a prophylaxis, if you really must go to high risk situation | 23:35 |
| de-facto | .title https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785 | 23:37 |
| nixonix | .title https://edition.cnn.com/2021/09/27/health/covid-treatment-pill-khn-partner/index.html EIDD-2801. its like 1.5 years ago, when we started to talk about this... | 23:37 |
| de-facto | .title https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2775984 | 23:37 |
| Brainstorm | nixonix: From edition.cnn.com: A pill to treat Covid-19: 'We're talking about a return to, maybe, normal life' - CNN | 23:37 |
| Brainstorm | de-facto: From jamanetwork.com: In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2 | Global Health | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network | 23:37 |
| nixonix | slap that bot | 23:37 |
| * de-facto slaps Brainstorm | 23:38 | |
| Brainstorm | de-facto: Do as you wish! | 23:38 |
| * de-facto slaps Brainstorm again | 23:38 | |
| Brainstorm | de-facto: Do as you wish! | 23:38 |
| de-facto | meh | 23:38 |
| de-facto | .title https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785 | 23:38 |
| Brainstorm | de-facto: From jamanetwork.com: In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2 | Global Health | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network | 23:38 |
| de-facto | .title https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2775984 | 23:38 |
| Brainstorm | de-facto: From jamanetwork.com: Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial | Pathology and Laboratory Medicine | JAMA [...] | 23:38 |
| de-facto | yeah nixonix inferferon (alpha?) spray would be a great idea probably | 23:39 |
| de-facto | .title https://www.nature.com/articles/s41586-021-03696-9 | 23:44 |
| Brainstorm | de-facto: From www.nature.com: Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection | Nature | 23:44 |
| de-facto | Nusszweig lab ^^ | 23:46 |
| de-facto | *Nussenzweig | 23:47 |
| Brainstorm | New from CIDRAP: Rural Americans more likely to die from COVID-19: Stephanie Soucheray | News Reporter | CIDRAP News Sep 30, 2021 People in rural areas are currently twice as likely to die from COVID-19 as their urban peers. → https://is.gd/rQEwCO | 23:49 |
| nixonix | alpha or beta prob all useful, because cells use common IFNAR receptor complex, and activete t-cells, dendritic and nk cells, which then produce IFN-gamma that activates b-cells. and sars2 suppresses that initial interferon response | 23:51 |
| nixonix | but there are different versions of those, depending on genes that express those subtypes. not sure about the differencies in practice. then recombinants that are modified somehow. there was some recent news if i find it | 23:53 |
| de-facto | .title https://edition.cnn.com/2021/09/21/health/johnson-vaccine-two-doses-booster/index.html | 23:54 |
| Brainstorm | de-facto: From edition.cnn.com: Two dose version of Johnson & Johnson shot 94% effective against Covid-19, study finds - CNN | 23:54 |
| de-facto | "A second study showed people given a booster shot six months or longer after their first dose had a 12-fold increase in antibodies -- compared to a four-fold increase for people who got a second dose at two months. " | 23:54 |
| de-facto | that is interesting, so tripling the time between primer and booster tripples ab titers? | 23:54 |
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