| nixonix | .title https://www.sciencedirect.com/science/article/pii/S1201971221006779 | 00:00 |
|---|---|---|
| Brainstorm | nixonix: From www.sciencedirect.com: Efficacy and safety of pegylated interferon-α2b in moderate COVID-19: a phase 3, randomized, comparator-controlled, open-label study - ScienceDirect | 00:00 |
| Brainstorm | Updates for Bahrain: +44 cases (now 275021), +15765 tests (now 6.4 million) since 23 hours ago | 00:01 |
| nixonix | jnj booster looks good in that, because long dose interval, after the 1st. so theres less antibodies vs the viral vector present (which made az's 2nd dose look inefficient) | 00:01 |
| nixonix | the same would work with all the viral vector vaxes (for sputnik doesn matter that much because 2 vectors - except another one is ad5 that many has antibodies agains, although maybe fewer now during the rona restrictions) | 00:03 |
| nixonix | yet sputnik is weaker than az, according to that recent study | 00:03 |
| nixonix | but better than those chinese vaxes. i wonder if chinese will have something better soon | 00:04 |
| de-facto | yeah that might be one of the effects but i would assume it also is affected by maturing on the first shot | 00:05 |
| de-facto | maturing affinity against sars-cov-2 s-protein | 00:05 |
| nixonix | it looks like they are behind in vax research, despite daszik leaking them all the g-o-f secrets and stuff... | 00:08 |
| nixonix | you saw that sanofi mrna news? they are ditching their mrna vax that didnt have modified nucleotides, like curevac | 00:09 |
| nixonix | funny they tried it too in the first place. i think it was because they saw the market there, potentially lisencing their own solution instead of pseudouridine use owned by kariko | 00:10 |
| Brainstorm | New from WebMD: Chief Medical Officer Was Silenced in Canada's Residential Schools: As tuberculosis infections spread in schools, it was "almost as if the prime conditions for the outbreak of epidemics had been deliberately created," the official said. → https://is.gd/PfIR37 | 00:11 |
| nixonix | *licensing. how do you know which way it should be, c and s... | 00:11 |
| de-facto | interesting | 00:12 |
| de-facto | they try to continue one against influenza though | 00:12 |
| de-facto | would be interesting to see if nucleoside modified or not | 00:13 |
| de-facto | .title https://www.sanofi.com/en/media-room/press-releases/2021/2021-09-28-08-00-00-2304069# | 00:13 |
| Brainstorm | de-facto: From www.sanofi.com: Sanofi announces positive Phase 1/2 study interim results for its first mRNA-based vaccine candidate - Sanofi | 00:13 |
| nixonix | .title https://endpts.com/sanofi-calls-it-quits-on-mrna-covid-19-shots-scrapping-vaccine-from-recent-translate-bio-buyout/ | 00:15 |
| Brainstorm | nixonix: From endpts.com: Sanofi calls it quits on mRNA Covid-19 shots, scrapping vaccine from $3.2B Translate Bio buyout – Endpoints News | 00:15 |
| nixonix | they have their adjuvanted vax (squalene AS03 from GSK). maybe their new trial data will come soon | 00:16 |
| nixonix | with that adjuvant antibody maturation worked well in flu vax (which was pandemrix i think in the study where they compared it to some other vaxes, and it was superior) | 00:17 |
| nixonix | why wouldnt the next generation flu vaxes be way better? S1 of sars2 has higher mutation rate nowdays than HA1 of flu A | 00:19 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): An excellent article describing what makes SARS COV 2 so bad.Unlike other used viruses the Used Virus🚘 Salesmen™️ sell, Cov2 retains it's devastational value.How? By rapidly spreading before immune memory can respond and overstimulating it.Cov2 makes us attack ourselves [... want %more?] → https://is.gd/nn5AyS | 00:22 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1265505689822265346 "by 5 years" | 00:28 |
| Brainstorm | nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "You have to pulse the infected cells with interferon. If there still is no MHC I then Houston we have a problem. The proof is in the pudding though, [...] | 00:28 |
| nixonix | [Wednesday, May 27, 2020] [8:58:59 PM EEST] <nixonix> a chinese preprint claiming ORF8 of sars-2 targets MHC-I on the surface of infected cells, unlike what sars-1 did https://www.biorxiv.org/content/10.1101/2020.05.24.111823v1 | 00:30 |
| Brainstorm | New from Contagion Live: us: PROVENT Trial: AZD7442 as Long-Acting Pre-Exposure Prophylaxis Protects Against Symptomatic COVID-19 → https://is.gd/3aDofv | 00:32 |
| Brainstorm | Updates for Italy: +4094 cases (now 4.7 million), +51 deaths (now 130921) since a day ago | 00:38 |
| nixonix | oh yeah, i remembered those az moabs had something interesting. they have modified Fc ends to improve half-life, preventing Fc-mediated effector functions consuming them | 00:42 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.08.30.21262666v1.full | 00:42 |
| Brainstorm | nixonix: From www.medrxiv.org: AZD7442 demonstrates prophylactic and therapeutic efficacy in non-human primates and extended half-life in humans | medRxiv | 00:42 |
| nixonix | .title https://twitter.com/EricTopol/status/1443702187159285784 | 00:45 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "Does vaccination reduce the severity and life impact of #LongCovid? A new preprint study with 455 vaccinated individuals and 455 matched controls supports benefit at 4 months [...] | 00:45 |
| nixonix | By 120 days, vaccination reduced the long COVID symptoms (mean (SD) ST score in the vaccination group 13·0 (9·4) vs. 14·8 (9·8) in the control group; mean difference: -1·8, 95% CI -2·5 to -1·0) and doubled the rate of patients in complete remission (remission rate 16·6% vs 7·5%, HR: 1·97, 95% CI 1·23 to 3·15). | 00:47 |
| nixonix | over 16% of vaccinated had a complete recovering from symptoms in 120 days. yay! | 00:48 |
| nixonix | Furthermore, vaccination reduced both disease impact on patients’ lives (mean (SD) IT score 24.3 (16·7) vs 27·6 (16·7); mean difference: -3·3, 95% CI -6·2 to -0·5) and the proportion of patients with an unacceptable symptom state (38.9% vs 46.4%, risk difference -7·5%, 95% CI -14·4 to -0·5) | 00:48 |
| de-facto | could that ORF8 be the secret behind Delta fitness? | 00:48 |
| nixonix | no, it was there all the time. meaning that MHC-I downregulating function | 00:49 |
| de-facto | afaik delta accumulated quite some mutations in ORF8 | 00:49 |
| nixonix | i dont think there's a good paper out yet on delta's immune evasion abilities. there was one about 1.1.7 in june i think | 00:49 |
| de-facto | and the furin cleavage site alone is not responsible for its increased fitness | 00:50 |
| nixonix | yeah some other stuff in orf8 maybe | 00:50 |
| nixonix | it has syncytia improved | 00:50 |
| nixonix | which is caused by the same mutation that improves furin cleavage, PRRAR->RRRAR (P681R i think) | 00:51 |
| nixonix | leonardi wrote something about its affects on neurons, but i had to look it more closely. syncytia between them, if its neurotropic (current assumption is, straight neuroinvasion is rare, so more likely its some immune cell infiltration - which i think leonardi thinks its due to killer t-cells, possibly because of that SEB SAG (: but it could be | 00:53 |
| nixonix | some other immune cell infiltration too) | 00:53 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1433451862246793221 | 00:54 |
| Brainstorm | nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "Sars cov 2 Spike is able to fuse human neurons, and organelles like mitochondria will pass between them! Fascinating." | 42l - nitter | 00:54 |
| nixonix | "yes, hiv also does it" | 01:00 |
| de-facto | fusing immortal neurons, yuck | 01:01 |
| nixonix | it looks like crossing BBB is rare, so its mostly about something else, those brain damages | 01:05 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1393313134237077508 | 01:07 |
| Brainstorm | nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "P681R could be turning those "undetectable" viral infections into cases due to its ability to swallow T cells with Syncitia" | nitter | 01:07 |
| de-facto | .title https://www.nature.com/articles/s41467-021-22036-z | 01:13 |
| Brainstorm | de-facto: From www.nature.com: Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection | Nature Communications | 01:13 |
| de-facto | .title https://www.nature.com/articles/s41418-021-00782-3 | 01:16 |
| Brainstorm | de-facto: From www.nature.com: SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination | Cell Death & Differentiation | 01:16 |
| de-facto | could this be related to | 01:16 |
| de-facto | title https://onlinelibrary.wiley.com/doi/10.1111/bjh.17116 | 01:16 |
| de-facto | .title https://onlinelibrary.wiley.com/doi/10.1111/bjh.17116 | 01:16 |
| Brainstorm | de-facto: From onlinelibrary.wiley.com: SARS‐CoV‐2‐induced remission of Hodgkin lymphoma - Challenor - 2021 - British Journal of Haematology - Wiley Online Library | 01:16 |
| nixonix | i dont know why leonardi thinks, that cellular reactivity to sars2 (when no abs present), could be because of syncytia. it seems its related to this, but i have to think if i can follow his logic to t-cell reactivity (without abs): | 01:23 |
| nixonix | "syncytium, which could readily internalize multiple lines of lymphocytes to form typical cell-in-cell structures, remarkably leading to the death of internalized cells. This membrane fusion is dictated by a bi-arginine motif within the polybasic S1/S2 cleavage site, which is frequently present in the surface glycoprotein of most highly contagious | 01:23 |
| nixonix | viruses | 01:23 |
| Brainstorm | New from Ars Technica: Science: A year later, 45% of COVID patients in Wuhan still have symptoms → https://is.gd/8mz3K0 | 01:25 |
| nixonix | those t-cells inside syncytia would then be chopped up, and parts of them could be presented in MHC-I or MHC-II if its APC. somehow from this it could follow that there are t-cells that regogn those antigens, but not b-cells, because no abs | 01:26 |
| nixonix | maybe the missing part would be b-cell priming when they dont encounter virions, or in some cases when it spreads mostly cell-to-cell or something | 01:28 |
| nixonix | yeayeah brainström, but did you see that with vax after 120 days over 16% have got rid of all the symptoms? | 01:29 |
| nixonix | and the proportion of patients with an unacceptable symptom state (38.9% vs 46.4%, risk difference -7·5%, 95% CI -14·4 to -0·5) | 01:30 |
| nixonix | we need more acceptance. NLP will program your state of mind to accept it will never be the same... | 01:31 |
| nixonix | strong titers, boosters, and less damage | 01:35 |
| de-facto | the more i read about this virus the more certain i am that i dont want to get that damn thing | 01:42 |
| nixonix | functional SARS-CoV-2-specific memory T and B cells were enriched at the site of infection compared to those of blood. Detailed evaluation of the lung immune compartment revealed dysregulated respiratory CD8+ T cell responses were associated with the impaired lung function following acute COVID-19. Single cell transcriptomic analysis identified the | 01:44 |
| nixonix | potential pathogenic subsets of respiratory CD8+ T cells contributing to persistent tissue conditions following COVID-19 | 01:44 |
| nixonix | t-cells that became crazy because of superantigen in S? | 01:44 |
| nixonix | .title https://www.science.org/doi/10.1126/sciimmunol.abk1741 | 01:46 |
| Brainstorm | nixonix: From www.science.org: Immune signatures underlying post-acute COVID-19 lung sequelae | 01:46 |
| nixonix | Notably, respiratory CD8+ T cells were negatively correlated with lung function parameters and positively correlated with lung pathological parameters, suggesting a potential role of respiratory CD8+ T cells in contributing to the development of lung sequelae following acute COVID-19 | 01:55 |
| nixonix | they then tested infecting flu in mice, and compared lung recovering in group where they depleted cd8 killer t-cells: | 01:56 |
| nixonix | dysfunction in the small airways was rescued by the depletion of CD8+ T cells in aged mice following the recovery of primary viral pneumonia .. in CD8+ T cell-depleted animals, the smallest airways showed significant functional recovery following infection | 01:57 |
| Brainstorm | New from Nature Vaccines: Cuicui Ma et al.: A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway → https://is.gd/tiSS4x | 01:57 |
| nixonix | (there is also rare cd4+ killer t-cells. almost every combination of t-cells exist, but some of them not very relevant, or not well known what they do) | 01:58 |
| nixonix | somebody should link that to leonardi | 01:59 |
| nixonix | It is thus possible that SARS-CoV-2 antigen may also be persistent for a period of time after infectious virus clearance, thereby sustaining and/or stimulating CD103- TRM cells to cause tissue injury. Alternatively, a portion of CD69+CD103- T cells may be restricted and stimulated by self-antigen, as those of autoantibodies reported to develop | 02:00 |
| nixonix | following SARS-CoV-2 infection | 02:00 |
| nana_ | think I'm going to go ahead and get a booster | 02:05 |
| Brainstorm | Updates for France: +56105 cases (now 7.1 million) since 23 hours ago — United Kingdom: +72171 cases (now 7.8 million), +407 deaths (now 137043) since 23 hours ago — India: +49037 cases (now 33.8 million), +959 deaths (now 448372) since 23 hours ago — Netherlands: +20810 cases (now 2.0 million), +81 deaths (now 18583) since 11 days ago | 02:30 |
| nixonix | .title https://twitter.com/RadCentrism/status/1443714964963790849 | 02:32 |
| Brainstorm | nixonix: From twitter.com: Radical Centrist, wrathful tantric deity (@RadCentrism): "Fang Li, an expert on coronavirus cell entry: "hidden RBD may lead to poor recognition of...host receptor and inefficient entry…CoV-2 [...] | 02:32 |
| de-facto | .title https://www.nature.com/articles/s41392-020-00460-9 | 02:44 |
| Brainstorm | de-facto: From www.nature.com: Not only ACE2—the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19 | Signal Transduction and [...] | 02:44 |
| de-facto | .title https://www.pnas.org/content/117/21/11727 | 02:49 |
| Brainstorm | de-facto: From www.pnas.org: Cell entry mechanisms of SARS-CoV-2 | PNAS | 02:49 |
| de-facto | .title https://www.cell.com/cell/fulltext/S0092-8674(21)00993-4 | 02:55 |
| Brainstorm | de-facto: From www.cell.com: Delivering the message: How a novel technology enabled the rapid development of effective vaccines: Cell | 02:55 |
| de-facto | really interesting paper about mRNA technology | 02:57 |
| de-facto | nixonix, ^^ | 03:00 |
| nixonix | yeah, ill look at it tomorrow | 03:07 |
| Brainstorm | Updates for Gabon: +640 cases (now 30155), +3 deaths (now 186), +13681 tests (now 1.2 million) since 2 days ago — Mauritania: +41 cases (now 36030), +1 deaths (now 775), +1725 tests (now 471374) since 21 hours ago — Guinea: +19 cases (now 30411), +1 deaths (now 379), +1297 tests (now 555954) since a day ago | 03:07 |
| nixonix | could it be as simple as give those with severe symptoms cd8 depleting antibodies in lungs | 03:08 |
| nixonix | they use them in some assays i think, alpha-cd8 or something | 03:08 |
| nixonix | maybe the same should be done more often after some other type of viral infections too then | 03:09 |
| nixonix | especially if Tregs take hit, like with sars2 | 03:09 |
| nixonix | send it to leonardi, those with twitter acc | 03:11 |
| lastshell | why the CDC is forcing get vaccine to the people who already had covid ? does natural inmunity doesn't count ? | 03:23 |
| Brainstorm | Updates for Haiti: +269 cases (now 21916), +1 deaths (now 611), +2704 tests (now 120282) since 2 days ago — Belize: +233 cases (now 20801), +5 deaths (now 414), +1979 tests (now 263418) since 21 hours ago — Djibouti: +106 cases (now 12811), +903 tests (now 221575) since a day ago — Curacao: +35 cases (now 16500), +1 deaths (now 163), +1822 tests (now 278166) since 23 hours ago | 03:32 |
| Brainstorm | New from COVID tweets: BNO Newsroom (@BNODesk): U.S. COVID update: Daily cases drop 11 days in a row- New cases: 117,478- Average: 111,863 (-1,824)- In hospital: 75,961 (-1,779)- In ICU: 21,001 (-443)- New deaths: 2,840- Average: 1,941 (-61)More data: newsnodes.com/us → https://is.gd/i5tMI0 | 03:34 |
| Brainstorm | New from COVID tweets: Kristen (@AngelsRAmongU): Long story short; everyone in the mentioned study already had long term Covid. Those who were vaccinated, had doubled the rate of complete remission at 4 months. #GetVaccinated twitter.com/EricTopol/stat… → https://is.gd/QDlmv7 | 03:44 |
| Brainstorm | New from Politico: Council presidency: Even the European Commission broke lockdown rules — over a seating spat → https://is.gd/GDRoOn | 04:05 |
| Brainstorm | Updates for Panama: +262 cases (now 467113), +5 deaths (now 7228), +7648 tests (now 3.9 million) since 22 hours ago — Gibraltar: +8 cases (now 5549), +1194 tests (now 361496) since a day ago — Guinea-Bissau: +4 cases (now 6107), +304 tests (now 97982) since a day ago | 04:09 |
| Brainstorm | Updates for South Korea: +2484 cases (now 313773), +16 deaths (now 2497), +51966 tests (now 14.6 million) since 22 hours ago — Australia: +3922 cases (now 107128), +31 deaths (now 1309), +426706 tests (now 38.0 million) since 23 hours ago — New Zealand: +132 cases (now 4292), +19039 tests (now 3.4 million) since 23 hours ago | 04:34 |
| Brainstorm | Updates for Belgium: +2133 cases (now 1.2 million), +7 deaths (now 25602) since 23 hours ago — Peru: +1016 cases (now 2.2 million), +28 deaths (now 199395), +43067 tests (now 17.9 million) since 23 hours ago — United Kingdom: +54256 cases (now 7.8 million) since 22 hours ago — Netherlands: +76 cases (now 2.0 million), +1 deaths (now 18584) since 3 hours ago | 05:36 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): What's 7 times incalculable?The number of lost American lives from Covid passed 700,000 tonight pic.twitter.com/060U9J9C75 → https://is.gd/jz7WF6 | 05:51 |
| Brainstorm | New from r/WorldNews: worldnews: New U.S. travel rules excludes those vaccinated with Russia's Sputnik V → https://is.gd/aoziAL | 06:12 |
| Brainstorm | Updates for India: +26727 cases (now 33.8 million), +1520899 tests (now 570.5 million) since 22 hours ago | 07:04 |
| Brainstorm | New from The Indian Express: World: Number of weekly COVID-19 cases and deaths continue to decline globally: WHO → https://is.gd/ReeaQt | 07:06 |
| Brainstorm | New from The Indian Express: World: How Asia, once a vaccination laggard, is revving up inoculations → https://is.gd/1jrAi4 | 07:27 |
| Brainstorm | Updates for Ceara, Brazil: +4532 cases (now 940463), +11 deaths (now 24221) since a day ago — Kedah, Malaysia: +1033 cases (now 134835) since a day ago — Lombardy, Italy: +401 cases (now 883744), +4 deaths (now 34041) since a day ago — Australian Capital Territory, Australia: +52 cases (now 1011), +2 deaths (now 8) since a day ago | 07:41 |
| Brainstorm | New from r/Science: science: Case report of restless anal syndrome as restless legs syndrome variant after COVID-19 → https://is.gd/0vMwxz | 07:59 |
| Brainstormie | New from The Indian Express: World: Declining global covid-19 cases, North Korea test-fires missile: 5 overnight developments from around the globe → https://is.gd/5dbJc7 | 08:11 |
| Brainstorm | Updates for St. Barthelemy: +1 deaths (now 4) since a day ago | 08:31 |
| Brainstorm | New from The Indian Express: World: Havana reopens its beaches, citing high vaccination rate → https://is.gd/7QZsLC | 08:52 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | October 01, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/CixrVc | 09:03 |
| Brainstorm | Updates for Taiwan: +11 cases (now 16234), +1 deaths (now 843), +38940 tests (now 6.4 million) since 22 hours ago | 09:08 |
| Brainstorm | Updates for Georgia: +1751 cases (now 614763), +30 deaths (now 8976), +42657 tests (now 9.0 million) since 21 hours ago — Armenia: +934 cases (now 262631), +20 deaths (now 5339), +11385 tests (now 1.7 million) since 21 hours ago — Czechia: +923 cases (now 1.7 million), +16 deaths (now 30475), +84954 tests (now 38.2 million) since 22 hours ago [... want %more?] | 09:33 |
| Brainstorm | New from The Indian Express (Health): Health: Safe to give Covid-19 shot and flu vaccine at the same time, says UK study → https://is.gd/yvoxAG | 09:35 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): How Portugal achieved the highest vaccinatuon rate in Europe and now has half the Covid mortality than the rest of Europe and one tenth that of the US. washingtonpost.com/world/2021/09/… → https://is.gd/6mA4SF | 09:56 |
| Brainstorm | Updates for Estonia: +729 cases (now 156986), +6348 tests (now 1.9 million) since 22 hours ago | 10:35 |
| Brainstorm | Updates for Austria: +1869 cases (now 744964), +5 deaths (now 11014), +290255 tests (now 87.5 million) since 22 hours ago — Slovakia: +1216 cases (now 413723), +12 deaths (now 12649), +9308 tests (now 3.6 million) since 22 hours ago | 11:00 |
| Brainstorm | New from BMJ: Vaccinating against covid and flu at same time is safe, study shows: Administering an influenza vaccine at the same time as a second dose of a covid-19 vaccine produced no safety concerns and preserves the immune response to both vaccines, say researchers.1The results... → https://is.gd/zBPUts | 11:00 |
| Brainstorm | New from BBC Health: (news): Covid-19 vaccinations: More than 50 nations have missed a target set by the WHO → https://is.gd/17zdRa | 11:22 |
| Brainstorm | New from r/WorldNews: worldnews: Prime Minister Scott Morrison said Australia will reopen its international borders next month. - Tetap Awasi → https://is.gd/ywApVL | 11:33 |
| Brainstorm | Updates for Russia: +48410 cases (now 7.5 million), +2411 deaths (now 208142), +600000 tests (now 192.1 million) since 22 hours ago — Latvia: +1127 cases (now 159418), +4 deaths (now 2721), +25460 tests (now 4.4 million) since 22 hours ago | 11:37 |
| Brainstorm | New from BMJ: Mass testing of university students for covid-19: People can clearly incubate and transmit SARS-CoV-2 in the absence of symptoms.1 Nonetheless, the value of mass testing (large scale asymptomatic screening to identify cases) has been contested.23 In... → https://is.gd/Kzl0pq | 11:54 |
| Brainstorm | Updates for Indonesia: +1624 cases (now 4.2 million), +87 deaths (now 142026), +251368 tests (now 39.4 million) since 20 hours ago — Poland: +1361 cases (now 2.9 million), +16 deaths (now 75666), +42843 tests (now 20.9 million) since a day ago — Finland: +562 cases (now 142114), +14113 tests (now 7.1 million) since 20 hours ago | 12:02 |
| Brainstorm | New from StatNews: Breaking News: Merck’s antiviral pill reduces hospitalization of Covid patients, a possible game-changer for treatment → https://is.gd/GNZ8Hf | 12:05 |
| Brainstorm | New from r/WorldNews: worldnews: Merck’s experimental pill to treat covid-19 cuts risk of hospitalization and death in half, the pharmaceutical company reports → https://is.gd/y82mnD | 12:27 |
| Brainstorm | Updates for Hong Kong: +4 cases (now 12222), +11857 vaccines (now 4.5 million) since 23 hours ago | 12:39 |
| Brainstorm | New from Reddit (test): COVID19: Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study → https://is.gd/9ZIBwW | 12:49 |
| Brainstorm | New from The Indian Express: World: Fire at COVID-19 hospital in Romania kills nine people → https://is.gd/JqXUG0 | 12:59 |
| Brainstorm | Updates for UAE: +276 cases (now 736268), +3 deaths (now 2100), +293853 tests (now 84.3 million) since 22 hours ago — Uganda: +170 cases (now 123742), +3 deaths (now 3159), +3726 tests (now 1.7 million) since 21 hours ago | 13:04 |
| Brainstorm | Updates for Romania: +10887 cases (now 1.2 million), +169 deaths (now 37210), +67047 tests (now 12.9 million) since 23 hours ago — Senegal: +7 cases (now 73782), +1433 tests (now 801048) since 21 hours ago | 13:29 |
| Brainstorm | New from BMJ: Covid-19: Lancet investigation into origin of pandemic shuts down over bias risk: The work of a task force commissioned by the Lancet into the origins of covid-19 has folded after concerns about the conflicts of interest of one its members and his ties through a non-profit... → https://is.gd/EtIkSs | 14:03 |
| Brainstorm | Updates for Nepal: +898 cases (now 795959), +13 deaths (now 11148), +10113 tests (now 4.2 million) since 22 hours ago — Laos: +464 cases (now 24310), +2 deaths (now 20), +6393 tests (now 501606) since a day ago — Brunei: +376 cases (now 7326), +5271 tests (now 361082) since 23 hours ago — Qatar: +92 cases (now 236735), +5431 tests (now 2.7 million) since 21 hours ago | 14:06 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): This could turn out to be one of the most important advances to counter Covid. Molnupiravir, a pill for 5 days (I'll nickname "M-pack") to markedly reduce hospitalization. Await details beyond press release, including safetystatnews.com/2021/10/01/mer… by @matthewherper @statnews pic.twitter.com/hKBZC5Y71Z → https://is.gd/igc5Mx | 14:25 |
| Brainstorm | Updates for Switzerland: +2352 cases (now 841571), +94 deaths (now 11104), +44078 tests (now 10.9 million) since 23 hours ago | 14:31 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The fact that the new clinical trial was stopped by the Data and Safety Monitoring Board early because of overwhelming efficacy, deeming it unethical to proceed, would be considered a Eureka moment in the fight against Covid → https://is.gd/4U3OFs | 14:47 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): A few additional points—Entry criteria mild to moderate Covid—8 deaths in the placebo group, 0 w/ M-pack—Efficacy seen across multiple variants, including Delta—I have a long history vs Merck (Vioxx) w/ a bias against this company (drug was made by Ridgeback Biotherapuetics) → https://is.gd/ohu84s | 15:09 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Merck’s Covid-19 pill reduced hospitalizations in a study; Dems start scaling back drug-pricing plans → https://is.gd/g3AdEi | 15:31 |
| Brainstorm | New from The Indian Express: World: Japan’s pharmaceutical firm says ‘human error’ caused contamination of Moderna vaccines → https://is.gd/RRsvt2 | 15:42 |
| Brainstorm | New from r/WorldNews: worldnews: Get a friend vaccinated and eat out on us, Swiss govt tells citizens → https://is.gd/7X4UES | 16:04 |
| Brainstorm | Updates for Belarus: +1993 cases (now 540079), +16 deaths (now 4159), +39117 tests (now 8.5 million) since 22 hours ago — Saudi Arabia: +45 cases (now 547179), +3 deaths (now 8719), +54119 tests (now 29.0 million) since 21 hours ago — Denmark: +3 deaths (now 2659), +77180 tests (now 83.7 million) since 22 hours ago | 16:11 |
| Brainstorm | New from Contagion Live: Assessing Breakthrough Infections Associated with the AZD1222 Vaccine: Investigators examined asymptomatic infection and the duration of viral shedding in symptomatic breakthrough infections in a phase 3 study with the AZD1222 COVID-19 vaccine. → https://is.gd/oHoJOa | 16:15 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): "Notably, a significant proportion of vaccinees have neutralizing titers below the detection limit, and suggest a 3rd booster immunization might be warranted to enhance the antibody titers and T cell responses." → https://is.gd/tEEeFl | 16:27 |
| Brainstorm | Updates for Tanzania: +24479 cases (now 25846), +669 deaths (now 719) since 13 days ago — Lesotho: +6867 cases (now 21262), +229 deaths (now 632) since 13 days ago — Germany: +10978 cases (now 4.2 million) since 23 hours ago — Bangladesh: +847 cases (now 1.6 million), +21 deaths (now 27531), +24670 tests (now 9.8 million) since 22 hours ago | 16:36 |
| Brainstorm | New from WebMD: Silver Lining Found in Pandemic: Fewer Teens Are Vaping: A new report finds teens using electronic cigarettes nearly 40% less as they were kept home during the pandemic. → https://is.gd/O8664A | 16:50 |
| Brainstorm | Updates for India: +28536 cases (now 33.8 million), +818 deaths (now 448396) since 23 hours ago | 17:01 |
| Brainstorm | Updates for Greece: +2601 cases (now 658368), +32 deaths (now 14860), +215443 tests (now 20.4 million) since 23 hours ago — Netherlands: +1789 cases (now 2.0 million), +7 deaths (now 18590) since 15 hours ago | 17:38 |
| Brainstorm | New from COVID tweets: Dr. Angela Rasmussen (@angie_rasmussen): I spoke to @RebeccaDRobbins @nytimes about the very encouraging trial results for molnupiravir, a game-changing antiviral pill.But while it's great to have more tools for treating COVID-19, it's better to not get it at all. Get vaccinated. #VaccinesWorknytimes.com/2021/10/01/us/… → https://is.gd/30zGIX | 17:48 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Compare this with intravenous monoclonal antibodies in Phase 3 trial @NEJM this wk, a 71% reduction (4.6% vs 1.3%) hospitalization/death for outpatients w/ Covid < 7 days from symptom onset. nejm.org/doi/full/10.10…M-pack trial much higher risk patients: 14.3% in placebo group → https://is.gd/lFIPoB | 17:59 |
| sdfgsdfg | why arent we focusing on vaccinating the babies | 18:19 |
| sdfgsdfg | they also die ? | 18:19 |
| Brainstorm | Updates for Italy: +3403 cases (now 4.7 million), +52 deaths (now 130973), +602305 tests (now 92.8 million) since 18 hours ago — Switzerland: +1210 cases (now 841573) since 16 hours ago | 18:40 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Today's news about what appears to be a highly effective pill is welcome, to add to the anti-Covid armamentarium. What is missing, big, and for a long time, is this, and it needs to/can get fixed STAT:nytimes.com/2021/10/01/opi… @nytopinion by @michaelmina_lab and Steven Phillips pic.twitter.com/4PzLrHs8WJ → https://is.gd/hIo5F5 | 19:26 |
| Brainstorm | Updates for Canada: +9144 cases (now 1.6 million), +89 deaths (now 27929) since 23 hours ago | 19:30 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): As such, molnupiravir might not be absolutely ideal as a long-term standalone Covid19 antiviral drug. Though, as part of a drug cocktail (similarly to how we treat HIV/AIDS), it may really shine.5/ → https://is.gd/yXJfQE | 19:47 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): 2 new @CDCMMWR reports for preventing Covid infections in summer camps, a high-risk setting: vaccination, testing, mitigation measures collectively achieved near total protectioncdc.gov/mmwr/volumes/7… (on prevention)cdc.gov/mmwr/volumes/7… (on risk) pic.twitter.com/ATomIohuD1 → https://is.gd/XtBUi5 | 19:58 |
| Brainstorm | Updates for Moldova: +1289 cases (now 295681), +26 deaths (now 6803), +17893 tests (now 1.8 million) since 17 hours ago | 20:07 |
| Brainstorm | New from Reddit (test): nCoV: Merck says research shows its COVID-19 pill works against variants → https://is.gd/Cwr2t9 | 20:08 |
| Brainstorm | New from FDA Press Releases: FDA: FDA to Hold Advisory Committee Meetings to Discuss Emergency Use Authorization for Booster Doses and COVID-19 Vaccines for Younger Children → https://is.gd/1f5qbE | 20:19 |
| Brainstorm | New from r/Science: science: Newly discovered biomarker predicts COVID-19 death days in advance. Research found changes to electrical activity in the heart can help predict which hospitalized COVID-19 patients are more likely to decline and die. The biomarker is easily measurable and may predict death several days in advance. → https://is.gd/E9QaV1 | 20:30 |
| Brainstorm | Updates for Singapore: +2909 cases (now 99430), +8 deaths (now 103) since 18 hours ago — Spain: +2037 cases (now 5.0 million), +48 deaths (now 86463) since a day ago — France: +78 cases (now 7.1 million) since 18 hours ago | 20:32 |
| Brainstorm | New from Contagion Live: Risk Factors Associated with Readmission after COVID-19 Hospitalization: After an initial hospitalization for COVID-19, some patients may have specific risk factors that increase their likelihood of readmittance. → https://is.gd/z6VxJG | 20:52 |
| Brainstorm | Updates for India: +23887 cases (now 33.8 million), +233 deaths (now 448605) since 18 hours ago — Namibia: +91 cases (now 127680), +3 deaths (now 3514), +2169 tests (now 705503) since a day ago — Zambia: +68 cases (now 209114), +1 deaths (now 3649), +12898 tests (now 2.5 million) since 22 hours ago [... want %more?] | 21:09 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): More vaccination, less deaths, by state, updated to Sep 29thnytimes.com/2021/10/01/us/…A very strong relationshipFlorida remains the big outlier pic.twitter.com/VmgJRdsmZj → https://is.gd/FShnDc | 21:14 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): Many protagonists on either end of the Covid spectrum only rarely engage with each other, but often seem keen to pour out their wrath on anyone who fails their purity test, because they may acknowledge tradeoffs, or simply because they lack faith in their simplistic solutions.2/ → https://is.gd/Nlc3cT | 21:25 |
| Brainstorm | New from r/WorldNews: worldnews: Israel’s Covid Booster Rollout Shows Early Success As Cases, Hospitalizations Plummet → https://is.gd/njnk8F | 21:47 |
| Brainstorm | New from r/WorldNews: worldnews: Covid antiviral pill can halve risk of hospitalisation → https://is.gd/RFuVtw | 21:58 |
| xiuoxiu | small sample. proper RCT? independent researchers? | 22:00 |
| xiuoxiu | do i assume right, that all the production is reserved for yanks for the next couple of years, like most of modernas? and remdesivir when they still thought it was effective (it has some effect, but its kinda meh) | 22:04 |
| xiuoxiu | here's a suggestion for yanks: give it for vaccinated only (unless real medical reason not to get vax - most of time it's imagined, because real reasons are very rare) | 22:07 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: FDA Advisers to Weigh Moderna, J&J Boosters, Kids’ Covid Shots: also plans to discuss data on boosters using a different vaccine than the one originally given. → https://is.gd/ulje1Q | 22:09 |
| xiuoxiu | how would have ever guessed, that EIDD-2801 might be good? like 17 months 3 weeks ago... | 22:11 |
| ublx | xiuoxiu: https://www.science.org/content/blog-post/molnupiravir-thor-s-hammer-delivers | 22:16 |
| xiuoxiu | american unvaxed wont get in hospital in time, anyway. and when they do, its often too late for antivirals. and then they demand ivermectin... | 22:17 |
| Brainstorm | New from ScienceNews: A new antiviral pill cuts COVID-19 hospitalization and death rates: Merck says its drug, molnupiravir, stops viral replication and can be taken right after a COVID-19 diagnosis. → https://is.gd/ZLW2pt | 22:20 |
| xiuoxiu | "No safety signals were observed (there were more adverse events in the control group)" yeah, its an error catastrophe drug, but risks should be minor with short course | 22:20 |
| xiuoxiu | sure its oral, but availability and cost isnt something they are ready to prescribe for everybody that gets positive result | 22:22 |
| xiuoxiu | when was the last time they found really effective small molecule antiviral? (if the efficacy is real) | 22:23 |
| xiuoxiu | [Tuesday, April 7, 2020] [6:07:40 PM EEST] <nixonix> krql: i dont know, but if i understood right eg remdesivir binds to rdrp, but i just read adenosine analogs like eidd-1931 and its oral analog eidd-2801 can be used together with remdesivir. if virus has mutation making them resistant to one of them, the other one should work. so in | 22:24 |
| xiuoxiu | this case they compliment each other | 22:24 |
| xiuoxiu | *complement | 22:25 |
| xiuoxiu | .title https://www.eurekalert.org/news-releases/682020 this is where i read about it first, apr 6 2020 (and thought together with nafamostat, and possibly another adenosine analog, that there are bunch) | 22:32 |
| Brainstorm | xiuoxiu: From www.eurekalert.org: A new antiviral drug heading into clinical tr | EurekAlert! | 22:32 |
| xiuoxiu | remdesivir works, but its too weak alone, because sars2 can evolve fast in the body with selective pressure, and escape it | 22:33 |
| xiuoxiu | seems to be harder with molnupiravir, which suggests it really disables exon | 22:34 |
| Brainstorm | New from Contagion Live: Increased Hygiene, Motivated by COVID-19, Led to Fewer C Difficile Cases: The COVID-19 pandemic led people to take hygiene and sanitation more seriously, causing a decrease in C difficile infections. → https://is.gd/kBuNEn | 22:41 |
| xiuoxiu | [Sunday, April 12, 2020] [6:27:08 AM EEST] <yuriwho> LjL: this drug is worth following: https://www.genengnews.com/news/clinical-trial-evaluating-oral-drug-against-coronavirus-expected-to-start-later-this-spring/ | 22:42 |
| nixonix | .title https://twitter.com/DrEricDing/status/1443991674942861315 median time since 2nd dose 5.9 months | 22:50 |
| Brainstorm | nixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "ASYMPTOMATIC BREAKTHROUGH TRANSMISSION? Hospital #COVID19 outbreak in Israel 🇮🇱—38 of 42 were 2-dose Pfizer #vaccinated. On the day of diagnosis, only 24 symptomatic. [...] | 22:50 |
| de-facto | .title https://www.merck.com/news/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat/ | 22:51 |
| Brainstorm | de-facto: From www.merck.com: Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate [...] | 22:51 |
| de-facto | .title https://en.wikipedia.org/wiki/Molnupiravir | 22:54 |
| Brainstorm | de-facto: From en.wikipedia.org: Molnupiravir - Wikipedia | 22:54 |
| de-facto | "Molnupiravir (development codes MK-4482 and EIDD-2801) is an experimental antiviral drug which is orally active and was developed for the treatment of influenza. It is a prodrug of the synthetic nucleoside derivative N4-hydroxycytidine, and exerts its antiviral action through introduction of copying errors during viral RNA replication." | 22:55 |
| de-facto | .title https://www.translationalres.com/article/S1931-5244(19)30256-7/fulltext | 22:55 |
| Brainstorm | de-facto: From www.translationalres.com: Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model - Translational Research | 22:55 |
| de-facto | .title https://www.science.org/doi/10.1126/scitranslmed.aax5866 | 22:55 |
| Brainstorm | de-facto: From www.science.org: Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia | 22:55 |
| de-facto | hmm but being a nucleoside derivate, isnt that the same principle as Remdesivir? | 22:56 |
| nixonix | The MOVe-OUT trial (MK-4482-002) (NCT04575597) was a global Phase 3, randomized, placebo-controlled, double-blind, multi-site study of non-hospitalized adult patients with laboratory-confirmed mild to moderate COVID-19, at least one risk factor associated with poor disease outcomes, and symptom onset within five days prior to randomization | 22:56 |
| de-facto | making the transcription or replication choke on "fake" nucleosides? | 22:56 |
| nixonix | no, remdesivirs target is rdrp, molnu...something is prob exon, nsp12 if i recall | 22:57 |
| de-facto | idk to me that sounds like throwing a wrench into a gear, it would introduce copying errors in all that currently is copied requiring that nucleoside, right? | 22:57 |
| nixonix | no, nsp14 (rdrp is nsp12) | 22:57 |
| de-facto | remdesivir is also a pro-drug for an nucleoside derivate | 22:57 |
| de-facto | pretty much same principle afaik | 22:58 |
| de-facto | https://en.wikipedia.org/wiki/Remdesivir | 22:58 |
| nixonix | different target and antiviral mechanism | 22:58 |
| de-facto | "Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase." | 22:58 |
| nixonix | according to yuri its common when virus escape mutating one polymerase active site, its suspectible to inhibitor against another, like was done with hiv triple cocktail | 23:01 |
| Brainstorm | Updates for Chad: +4 cases (now 5042), +309 tests (now 146898) since 21 hours ago | 23:01 |
| de-facto | that is if both target the same molecular mechanism, hence are directly interdependent | 23:02 |
| de-facto | evading one increases the other and vise versa | 23:02 |
| nixonix | so giving them another nucleotide analog will improve efficacy. remdesivir or something else | 23:03 |
| nixonix | well, they affect replication, but different targets | 23:03 |
| de-facto | well unless the molecular mechanism is already jammed completely by one? | 23:03 |
| nixonix | (some of the possible alternatives have same targets, though) | 23:04 |
| de-facto | idk i dont like that principle | 23:04 |
| de-facto | why dont they develop small molecules that block some part of only SARS-CoV-2? | 23:04 |
| nixonix | yeah but it can escape if theres only one target, in hours or days | 23:04 |
| nixonix | maybe thats why remdesivir is just meh | 23:04 |
| de-facto | rather than introducing random errors in every RNA copy that is going on currently? | 23:04 |
| de-facto | btw how would it even evade that? its unspecific broad spectrum antival, targeting RNA itself isnt it? | 23:06 |
| nixonix | they could try two another types of nucleoside analogs too, with different targets. but its been slow with coctails, because one company wants to own the treatment and make money with it | 23:06 |
| nixonix | so it cant be too cheap, or owned by some other company. the other parts of cocktail | 23:06 |
| de-facto | maybe if SARs-CoV-2 could encode a small molecule itself that binds to that fake nucleoside hence renders it ineffective and enables high fidelity replication again? | 23:07 |
| nixonix | unless WHO or some govt trials do that. been slow with those too | 23:07 |
| de-facto | yeah i dont like that whole idea of nucleoside analogues | 23:07 |
| nixonix | whats the alternative? blocking or inhibiting tmprss2 (nafamostat), furin (not safe), or some other targets important for cells and human biology functioning. then its antibodies, like these monoclonals | 23:09 |
| de-facto | blocking some NSPs of SARs-CoV-2 | 23:10 |
| nixonix | not sure how effective nafamostat is alone anyway. it prevents another cleavage so making the fusion harder, but it could still happen (via that same route, esp if heparan sulfate is really involved and helping) | 23:11 |
| de-facto | something specific to SARS-CoV-2 replication cycle that is essential to it but does not affect other physiological functions (thats the challenge i guess) | 23:11 |
| nixonix | you can also inhibit cathepsin L but thats not effective route, giving some help depeding on cell type | 23:11 |
| de-facto | we need something that targets later replication cycle, hence when it already entered a cell | 23:12 |
| de-facto | because that could help in addition to antibodies | 23:12 |
| nixonix | i think those nucleoside analogs do just that, work inside cells | 23:13 |
| de-facto | how about some micro-RNA that would block SARS-CoV-2? | 23:13 |
| de-facto | or how about some small molecule that binds to sone of its non-structural but essential proteins? | 23:13 |
| de-facto | yes exactly nucleoside analogs work inside cells, but i would want something more specific to SARS-CoV-2 | 23:14 |
| nixonix | what would be essential target in accessory proteins? | 23:14 |
| de-facto | good question | 23:14 |
| nixonix | maybe something needed in golgi, if there are such | 23:15 |
| de-facto | i guess there are quite some papers about NSP (non-structural proteins) of SARS-CoV-2 evaluating drug targets | 23:15 |
| nixonix | but its damn slow, look at eidd-2801, i read about it 17 months 3 weeks ago. and nafamostat, even a bit earlier | 23:16 |
| nixonix | not to mention using cocktails of them... | 23:16 |
| nixonix | how can it be so slow? | 23:16 |
| de-facto | yeah they are much much too slow | 23:16 |
| de-facto | idk, they try to squeeze out the money of things they already have | 23:16 |
| nixonix | the reasoning for repurposing was, the tolerance its known and application process would be faster | 23:17 |
| de-facto | big pharma does not do research, they only transform ideas to profit by scaling | 23:17 |
| nixonix | its = is already | 23:17 |
| nixonix | something is wrong in that system, why it took this long for eidd-2801? why was remdesivir much faster | 23:18 |
| de-facto | the research is done at public funded universities or start ups, big pharma buys those and then tries to bring them onto the market and make a shitload of profit from that | 23:19 |
| de-facto | the advantage of EIDD-2801 is that it can be given orally while Remdesivir needs infusion | 23:27 |
| de-facto | so as a broad spectrum antiviral if its needed early in infection cycle to become effective it is a real advantage to not require infusion at hospital but being able to give people a pill they can take at home already | 23:28 |
| nixonix | .title https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7102646/ | 23:29 |
| Brainstorm | nixonix: From www.ncbi.nlm.nih.gov: Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study - PMC | 23:29 |
| nixonix | .title https://www.sciencedirect.com/science/article/abs/pii/S0166354220302710?via%3Dihub | 23:30 |
| nixonix | oral analogs are often less effective, so both would be useful | 23:31 |
| nixonix | .title https://www.sciencedirect.com/science/article/abs/pii/S0166354220302710?via%3Dihub | 23:31 |
| Brainstorm | nixonix: From www.sciencedirect.com: A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19 - ScienceDirect | 23:31 |
| de-facto | hmmm but Remdesivir is a pro-drug to the nucleoside analoge GS-441524, hence their binding puzzle with original Remdesivir does not make much sense to me thb | 23:34 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Delta and #COVIDisAirborne nytimes.com/2021/10/01/hea… @NYTScience by @apoorva_nyc Upgrade masks to counter itscientificamerican.com/article/why-we… @sciam by @tanyalewis314 pic.twitter.com/icuEeUxgMO → https://is.gd/BuPMJk | 23:34 |
| nixonix | "But a prophylactic drug has its own complications - how long do you need to keep taking it, and how long can you without side effects, for starters" | 23:35 |
| nixonix | i have a solution! lets have another dose of vaccine! | 23:35 |
| nixonix | cheap too | 23:35 |
| de-facto | crazy idea: cant we have a somewhat harmless virus replicating and encoding a micro-RNA that binds to SARS-CoV-2 RNA hence blocks only its specific replication? | 23:35 |
| de-facto | rhinovirus? :D | 23:36 |
| nixonix | not sure if thats possible for sars2 mrna in cytoplasm. i cant remember exactly how mirna worked, would need to check from that paper | 23:38 |
| de-facto | .title https://www.futuremedicine.com/doi/10.2217/fvl-2020-0389 | 23:39 |
| Brainstorm | de-facto: From www.futuremedicine.com: The role of miRNAs in COVID-19 disease | Future Virology | 23:40 |
| de-facto | can also used diagnostically | 23:40 |
| de-facto | .title https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009759 | 23:40 |
| Brainstorm | de-facto: From journals.plos.org: Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection | 23:40 |
| nixonix | but anyway, while some type of mirna treatments could be possible, and some viruses remain in homeostasis or something in cells for long periods, its prob not something that would be possible, like protection for years | 23:40 |
| nixonix | btw leonardi said later, after he had commented that second macrophage paper that it wasnt as worrying as the mouse study, well lemme find the tweet... | 23:42 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1443732542344114178 | 23:42 |
| Brainstorm | nixonix, the URL could not be loaded | 23:42 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1443732542344114178 | 23:42 |
| Brainstorm | nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "yea it wasn't inducing crazy cytokines. instead the virus is prob hanging out and replicating" | 42l - nitter | 23:42 |
| nixonix | maybe the replication couldnt be ruled out. they often use assays for cytokines to find different immune cell activity, but they arent necessary sure way. just easier | 23:43 |
| de-facto | how about an LNP that would dock to ACE2 and deliver miRNA to block SARS-CoV-2 ssRNA specifically by binding to it? | 23:45 |
| nixonix | leonardi is worried about things that are possible and there is some evidence suggesting it. many experts in media or twitter mostly cover things or give opinions, that are optimistic or wishful thinking | 23:46 |
| nixonix | if you were responsible in air security, human lives and health, would you take the optimistic approach like: well those counterfeit parts dont necessarily cause problems, or defects will be found in inspectations, so no worries, you are good to fly, probably | 23:47 |
| de-facto | hmmm | 23:49 |
| de-facto | .title https://journals.asm.org/doi/10.1128/mBio.01987-21 | 23:49 |
| Brainstorm | de-facto: From journals.asm.org: Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages | mBio | 23:49 |
| nixonix | lnp is hydrophobic material that goes through cell membrane. if docking to ace2 was wanted, it would be a nanoparticle with some kind of spikes preventing it to happen too easily (thats the purpose of spike proteins). you could use sars2 spikes, or HA1 of flu or whatever, because evolution has solved the mechanism for making it not too hard and not | 23:50 |
| nixonix | too easy already | 23:50 |
| nixonix | or fuses with them | 23:50 |
| nixonix | but ace2 blockers would be simpler if you want to block it (instead of deliver the payload) | 23:51 |
| nixonix | if some people still remember those immunocomplexes consisting of antibody-virion-ab-virion-... linked together, and cells somehow recognize it and causing stronger cytokine reaction, like that paper suggested, i wondered if that recognizing really is possible and how | 23:57 |
| nixonix | i found a mechanism that could explain, just by accident when reading something about mast cells. they have receptors for IgE that are crosslinked so, that they react only when two or more receptors recognize IgE that binds to them (allergic reaction, a topic which i dont know much about) | 23:58 |
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