| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): I don't like to gloat, but as virologist I always felt that you attack the VIRUS, not the downstream immune responses, as so many medics favor. Almost every serious drug development in COVID has followed this rule. So yeah, vindicated. → https://twitter.com/hjelle_brian/status/1457844200532103171 | 00:00 |
|---|---|---|
| Dredd | Following on from my earlier Pokemon joke I've re-written the theme song to be about covid 🤦♂️ | 00:30 |
| Dredd | https://gist.github.com/pwr22/319551d66599d5b777a5bb9e5cef58d5 | 00:30 |
| Brainstorm | Updates for Norway: +1051 cases (now 217449), +32303 tests (now 8.2 million) since 23 hours ago — Faroe Is.: +52 cases (now 2667), +1 deaths (now 6), +6000 tests (now 511000) since 23 hours ago | 00:30 |
| Brainstorm | New from The Lancet (Online): [Health Policy] How an outbreak became a pandemic: a chronological analysis of crucial junctures and international obligations in the early months of the COVID-19 pandemic: Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01897-3/fulltext | 00:34 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): There may be other issues, but the biggest reasons we don't have a serious vaccine for HIV, as I understand it.1. Surface proteins heavily covered by sugar residues.2. Surface proteins of very low abundance.3. Mutates a lot. (Prolly LEAST [... want %more?] → https://twitter.com/hjelle_brian/status/1457853667659321344 | 00:46 |
| Brainstorm | New from r/WorldNews: worldnews: Anti-vaxxers bribe doctors for fake vaccines in Greece, end up receiving real doses → https://old.reddit.com/r/worldnews/comments/qpqro0/antivaxxers_bribe_doctors_for_fake_vaccines_in/ | 01:20 |
| Brainstorm | Updates for Bulgaria: +5286 cases (now 638048), +334 deaths (now 25408), +48135 tests (now 5.9 million) since a day ago — United Kingdom: +32095 cases (now 9.4 million) since 15 hours ago | 01:38 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): This is demonstrated, but we still need to show that deer mice are experiencing an epizootic of SARS2. I fear this is coming.They come into houses, peeps.pubmed.ncbi.nlm.nih.gov/34127676/ → https://twitter.com/hjelle_brian/status/1457870359512842245 | 01:43 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): 20 months into the pandemic, what I've learned about the things that helped in Europe/North America- High trust in authorities- Good health infrastructure- Good social support (e.g. generous sick leave)- Vaccination programmes targeting [... want %more?] → https://twitter.com/BallouxFrancois/status/1457872951924203522 | 01:55 |
| Brainstorm | Updates for Uruguay: +142 cases (now 395410), +2 deaths (now 6088), +13990 tests (now 3.9 million) since a day ago | 02:03 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): And things I learned didn't help in Europe/North America- Low trust in authorities- Poor/unaccessible health infrastructure- Poor social support (e.g. no sick leave)- Vaccination programmes with no clear defined objective (i.e. first come, [... want %more?] → https://twitter.com/BallouxFrancois/status/1457872953836806144 | 02:06 |
| Brainstorm | Updates for Ivory Coast: +5 cases (now 61426), +14930 tests (now 1.1 million) since a day ago | 02:34 |
| Brainstorm | Updates for Belize: +268 cases (now 28162), +3083 tests (now 321004) since 3 days ago — Gabon: +116 cases (now 36310), +5 deaths (now 259), +5958 tests (now 1.4 million) since 7 hours ago | 02:59 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): To summarise.- SARSCoV2 is not a neurotropic virus- Encephalitis is an exceptionally uncommon complication of COVID19- Anosmia heals in ~99% cases- Anosmia does not seem to be linked to brain damage8/ → https://twitter.com/BallouxFrancois/status/1457889365787561984 | 03:02 |
| Brainstorm | New from r/WorldNews: worldnews: WHO casts doubt on Turkmenistan's zero-Covid claim → https://old.reddit.com/r/worldnews/comments/qptd2a/who_casts_doubt_on_turkmenistans_zerocovid_claim/ | 03:36 |
| Brainstorm | Updates for Bermuda: +11 cases (now 5688), +5196 tests (now 612105) since 3 days ago | 03:36 |
| -Bridgestorm- 🏠 Temblor! Sismo! Earthquake! 5.9 Mwp tremor, registered by 6 agencies, with 12 reports, 4 early, occurred 19 minutes ago (02:53:53 UTC), with a crescent moon, Near Coast Of Nicaragua (11.19, -86.6) ± 3 km, ↓33 km likely felt 230 km away (in Liberia, Masaya, León, Managua…) by 1.8 million people (www.seismicportal.eu) | 04:14 | |
| Brainstorm | Updates for United Kingdom: +32319 cases (now 9.4 million) since 18 hours ago — Netherlands: +28 cases (now 2.3 million) since 10 hours ago | 04:39 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Another Delta transmission in household study:"Effectiveness of full vaccination against transmission to unvaccinated household contacts was 63% (95% CI 46-75%)" among 7,771 contacts of 4,921 index cases.medrxiv.org/content/10.110… → https://twitter.com/EricTopol/status/1457913612765253634 | 04:43 |
| Brainstorm | New from r/WorldNews: worldnews: Auckland’s - The lockdown of New Zealand’s largest city is likely to end later this month. - News World → https://old.reddit.com/r/worldnews/comments/qpv399/aucklands_the_lockdown_of_new_zealands_largest/ | 05:05 |
| Brainstorm | New from Reddit (test): China_Flu: Whistleblower Indicates Unclean Data in Pfizer Vaccine Trials (Dr. Syed) → https://old.reddit.com/r/China_Flu/comments/qpvek9/whistleblower_indicates_unclean_data_in_pfizer/ | 05:27 |
| Brainstorm | Updates for Belgium: +24367 cases (now 1.4 million), +69 deaths (now 26200) since 2 days ago — Germany: +23712 cases (now 4.8 million) since 19 hours ago — Peru: +380 cases (now 2.2 million), +23 deaths (now 200469), +18817 tests (now 19.4 million) since 22 hours ago | 05:41 |
| Brainstorm | Updates for Yukon, Canada: +70 cases (now 1087) since 2 days ago — Aysen, Chile: +64 cases (now 8738) since 23 hours ago — Alaska, United States: +1355 cases (now 143473), +53 deaths (now 794) since 2 days ago — Falkland Islands (Malvinas), United Kingdom: +6 cases (now 78) since 23 hours ago | 06:31 |
| Brainstorm | New from The Indian Express: World: Thousands protest in New Zealand against Covid-19 vaccine mandate → https://indianexpress.com/article/world/thousands-protest-in-new-zealand-against-covid-19-vaccine-mandate-7614167/ | 06:33 |
| Brainstorm | New from The Indian Express: World: Widespread coronavirus infection found in Iowa deer, new study says → https://indianexpress.com/article/world/coronavirus-iowa-deer-7614156/ | 06:44 |
| sKep | %cases britain | 06:48 |
| Brainstorm | sKep: United Kingdom has had 9.4 million confirmed cases (14.1% of all people) and 142293 deaths (1.5% of cases) as of 2 hours ago. 340.8 million tests were done (2.8% positive). 50.2 million were vaccinated (75.6%). +32319 cases since 18 hours ago. See https://coronavirus.data.gov.uk/ | 06:48 |
| Brainstorm | New from r/WorldNews: worldnews: Analysis: COVID-19 pills are coming, but no substitute for vaccines, disease experts say → https://old.reddit.com/r/worldnews/comments/qpx9zo/analysis_covid19_pills_are_coming_but_no/ | 07:17 |
| Brainstorm | Updates for India: +10126 cases (now 34.4 million), +332 deaths (now 461389) since 22 hours ago | 07:33 |
| Brainstorm | New from The Indian Express: World: With tears, hugs and balloons, US allows vaccinated foreign travelers to enter → https://indianexpress.com/article/world/with-tears-hugs-and-balloons-us-allows-vaccinated-foreign-travelers-to-enter-7614258/ | 07:39 |
| -Bridgestorm- ⭕ Temblor! Sismo! Earthquake! 6.2 Mw tremor, registered by EMSC,GFZ,alomax, with 10 reports, 2 early, occurred 16 minutes ago (06:24:25 UTC), with a crescent moon, Near Coast Of Nicaragua (11.22, -86.51) ± 11 km likely felt 360 km away (in Masaya, León, Managua…) by 2.3 million people (www.seismicportal.eu) | 07:41 | |
| -Bridgestorm- 🏠 Sismo! Earthquake! 6.0 Mb tremor, registered by 4 agencies, occurred 27 minutes ago (06:24:23 UTC), with a crescent moon, Near Coast Of Nicaragua (11.21, -86.5) ± 2 km, ↓35 km likely felt 260 km away (in Masaya, Jinotepe, Rivas, Granada, Potosí…) by 321200 people (Twitter) | 07:51 | |
| Brainstorm | New from r/WorldNews: worldnews: Chinese city offers cash for clues as Covid outbreak declared a ‘people’s war’ → https://old.reddit.com/r/worldnews/comments/qpxte0/chinese_city_offers_cash_for_clues_as_covid/ | 08:01 |
| Brainstorm | Updates for United Kingdom: +32320 cases (now 9.4 million) since 22 hours ago | 08:35 |
| Brainstorm | New from BBC Health: (news): Covid-19: Vaccines to be compulsory for frontline NHS staff in England → https://www.bbc.co.uk/news/health-59215282 | 08:56 |
| Brainstorm | Updates for Czechia: +9282 cases (now 1.8 million), +120 deaths (now 31173), +142192 tests (now 41.3 million) since 23 hours ago — Georgia: +6021 cases (now 761067), +75 deaths (now 10584), +52033 tests (now 10.6 million) since 23 hours ago — Armenia: +1121 cases (now 322364), +62 deaths (now 6762), +9152 tests (now 2.2 million) since 23 hours ago | 09:00 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | November 09, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/qpyw4z/daily_discussion_thread_november_09_2021/ | 09:07 |
| Brainstorm | New from Politico: Coronavirus: COVID vaccination to become mandatory for NHS staff in England → https://www.politico.eu/article/covid-vaccination-mandatory-nhs-england/ | 09:41 |
| Brainstorm | New from The Indian Express: World: She died with long Covid. Should her organs have been donated? → https://indianexpress.com/article/world/organ-donation-coronavirus-heidi-ferrer-7614550/ | 09:52 |
| Brainstorm | Updates for Hungary: +4588 cases (now 914586), +123 deaths (now 31521), +19871 tests (now 7.6 million) since a day ago — Lithuania: +2314 cases (now 430855), +40 deaths (now 6175), +20533 tests (now 5.7 million) since a day ago | 10:08 |
| Brainstorm | New from r/WorldNews: worldnews: Intellectually Disabled Man Spared Imminent Execution After Catching COVID → https://old.reddit.com/r/worldnews/comments/qpzx61/intellectually_disabled_man_spared_imminent/ | 10:36 |
| Brainstorm | Updates for Russia: +39160 cases (now 8.9 million), +1211 deaths (now 249215), +2000000 tests (now 218.0 million) since a day ago — Estonia: +1089 cases (now 206972), +6 deaths (now 1623), +7638 tests (now 2.2 million) since a day ago — Germany: +23709 cases (now 4.8 million) since 22 hours ago | 10:39 |
| Brainstorm | New from BBC Health: (news): Covid: What are the vaccine rules for NHS staff and can I get a booster? → https://www.bbc.co.uk/news/health-55045639 | 10:48 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19: Vaccines to be compulsory for frontline NHS staff in England → https://old.reddit.com/r/worldnews/comments/qq08tw/covid19_vaccines_to_be_compulsory_for_frontline/ | 10:59 |
| Brainstorm | Updates for Austria: +7712 cases (now 899777), +39 deaths (now 11554), +9028 vaccines (now 6.0 million), +454958 tests (now 101.1 million) since a day ago — Laos: +1050 cases (now 48892), +3 deaths (now 89), +7107 tests (now 701049) since 20 hours ago — Taiwan: +6 cases (now 16451), +1 deaths (now 848), +73565 vaccines (now 17.6 million) since a day ago [... want %more?] | 11:10 |
| Brainstorm | Updates for Uganda: +19 cases (now 126644), +2 deaths (now 3230), +3262 tests (now 1.9 million) since a day ago | 11:35 |
| sdfgsdfg | so you look at the alpha and beta charts and see that they completely disappeared after some time and delta appeared. Isn't this.... kind of an obvious sign that something is not natural here | 11:35 |
| sdfgsdfg | or is this some natural pandemic pattern ? | 11:36 |
| sdfgsdfg | do viruses get a longer hook tail once in a while just casually, does it get longer and longer ? what's the frequency of these mutations ? I don't see a massive dick growing out of my forehead ? | 11:38 |
| sdfgsdfg | perhaps we should be nuking canada. french canadians seem a bit off | 11:40 |
| Brainstorm | New from BMJ: Life expectancy by ethnic group in England: The disproportionate effect of covid-19 on ethnic minority populations led to a welcome and overdue focus on ethnic disparities in health.1 Their higher covid-19 mortality was widely viewed as having... → http://feeds.bmj.com/~r/bmj/recent/~3/pWksP3M1JFE/bmj-2021-068537.short | 11:44 |
| Brainstorm | New from The Indian Express: World: Singapore grants 11th-hour stay of execution for Malaysian with COVID-19 → https://indianexpress.com/article/world/singapore-grants-11th-hour-stay-of-execution-for-malaysian-with-covid-19-7614812/ | 11:56 |
| Brainstorm | Updates for Slovakia: +4958 cases (now 526608), +45 deaths (now 13314), +19537 tests (now 4.1 million) since a day ago — Finland: +810 cases (now 165302), +33269 tests (now 7.6 million) since 23 hours ago | 12:00 |
| Brainstorm | Updates for Latvia: +1451 cases (now 233698), +46 deaths (now 3561), +16447 tests (now 5.1 million) since a day ago — Nepal: +443 cases (now 815372), +1 deaths (now 11454), +14918 tests (now 4.5 million) since a day ago — France: +1869 cases (now 7.3 million), +44 deaths (now 118926) since 21 hours ago | 12:37 |
| Brainstorm | New from BioNTech: BioNTech Announces Third Quarter 2021 Financial Results and Corporate Update: Delivered more than 2 billion doses of COMIRNATY/BNT162b2 in 2021 as of November 2 nd Demonstrated progress in expanding access to COVID-19 vaccine [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-announces-third-quarter-2021-financial-results-and | 12:51 |
| Brainstorm | Updates for Indonesia: +434 cases (now 4.2 million), +21 deaths (now 143578), +248015 tests (now 48.8 million) since a day ago — Zambia: +10 cases (now 209918), +4929 tests (now 2.6 million) since 15 hours ago — Senegal: +3 cases (now 73942), +1 deaths (now 1881), +762 tests (now 850301) since 22 hours ago | 13:02 |
| Brainstorm | New from EMA: What's new: PIP: Opinion/decision on a Paediatric investigation plan (PIP): Anti-C1s Humanized IgG4 Monoclonal Antibody (BIVV020), decision type: , therapeutic area: , PIP number: P/0087/2021 → https://www.ema.europa.eu/en/medicines/human/paediatric-investigation-plans/emea-002903-pip01-20 | 13:13 |
| de-facto | in the periods of variant transition one can see one variant on decline (e.g. Alpha) while the other variant is on increase (e.g. Delta) | 13:35 |
| Brainstorm | New from Reddit (test): China_Flu: Myocarditis following COVID-19 vaccination: magnetic resonance imaging study → https://old.reddit.com/r/China_Flu/comments/qq2j5t/myocarditis_following_covid19_vaccination/ | 13:36 |
| de-facto | so if both VoCs compete for reproduction in the same population at the same time under shared circumstances (such as containment measures induced by the increase of the new variant) one can fit two exponential functions on each of the VoCs incidence curves over time | 13:37 |
| Brainstorm | Updates for Iceland: +186 cases (now 14757), +14809 tests (now 1.2 million) since 23 hours ago | 13:40 |
| de-facto | then with those two fits e.g. Incidence(VoC, t) = Incidence(VoC, t0) * Rt(VoC)^(t/t_serial) the reproduction numbers are found as Rt(VoC) = [ Incidence(VoC, t) / Incidence(VoC, t0) ]^(t_serial / t) and thereby we know how much more contagious the new VoC is: Rt(VoC1) / Rt(VoC2) | 13:40 |
| de-facto | so if Rt(Initial) < Rt(B.1) < Rt(B.1.1.7) < Rt(B.1.617.2) < Rt(AY.4.2) its a no brainer that the more contagious VoCs got a replication advantage, hence take over the incidence in a population if competing with less fit ancestors under same conditions | 13:43 |
| de-facto | basically its "survival of the fittest (VoC)" | 13:43 |
| de-facto | not sure why, but it seems those jumps when a now CoV-VoC takes over are occuring when Rt(new) / Rt(old) ~ 1.4 - 1.5 hence when the new variant is about 40% or 50% more contagious | 13:45 |
| de-facto | probably some value determined by the epidemiological circumstances where those VoCs have to compete against each other | 13:46 |
| Brainstorm | New from COVID tweets: Dr Emma Hodcroft (@firefoxx66): So many times in the pandemic, people have declared we have it all figured out - #SARSCoV2 keeps showing us otherwise.Listen to the science, stay grounded, & be ready to react. Implement necessary measures, build trust, & publicly fight misinformation.And #Vaccinate!16/16 → https://twitter.com/firefoxx66/status/1458050261491068936 | 13:47 |
| Brainstorm | New from COVID tweets: Walter Verbrugghe (@WaVerbrugghe): Hoge Gezondheidsraad beveelt extra prik aan voor wie Janssen-vaccin kreeg standaard.be/cnt/dmf2021110… → https://twitter.com/WaVerbrugghe/status/1458055274116304897 | 13:58 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): ICU beds filling up in Germany as 4th wave slams Europe. We will follow- again, won't we?politico.eu/article/german… → https://twitter.com/hjelle_brian/status/1458057801998106625 | 14:09 |
| Brainstorm | Updates for Bangladesh: +206 cases (now 1.6 million), +3 deaths (now 27904), +17530 tests (now 10.5 million) since a day ago — UAE: +72 cases (now 740572), +285711 tests (now 95.7 million) since 23 hours ago | 14:11 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): I can see traveling even before the pandemic is conquered if we triple-vaxed carted around Pfizer or Merck drugs, popped them at first symptoms. That would likely do it, but few will be thusly positioned. → https://twitter.com/hjelle_brian/status/1458058629135757317 | 14:20 |
| dTal | so are we just doing "thusly" now | 14:32 |
| dTal | is that now an actual thing that people write unironically | 14:33 |
| Brainstorm | Updates for Vietnam: +8133 cases (now 984805), +88 deaths (now 22686), +282887 tests (now 62.7 million) since 23 hours ago — Germany: +23669 cases (now 4.8 million) since 23 hours ago | 14:36 |
| Brainstorm | New from NIH Director's blog: Israeli Study Shows How COVID-19 Immunity Wanes over Time: The winter holidays are approaching, and among the many things to be grateful for this year is that nearly 200 million Americans are fully vaccinated for COVID-19. That will make it [... want %more?] → https://directorsblog.nih.gov/2021/11/09/israeli-study-shows-how-covid-19-immunity-wanes-over-time/ | 15:05 |
| Brainstorm | New from Contagion Live: Improving COVID-19 Outcomes in HIV Patients: A new study looks at this population and what factors affect outcomes, including diagnosis. This is significant not only for pandemic response, but also preparedness for vulnerable patient populations. → https://www.contagionlive.com/view/improving-covid-19-outcomes-in-hiv-patients | 15:16 |
| Brainstorm | New from Pfizer: carterda: Biohaven and Pfizer Enter Strategic Collaboration for the Commercialization of Rimegepant Outside the United States → https://www.pfizer.com/news/press-release/press-release-detail/biohaven-and-pfizer-enter-strategic-collaboration | 15:27 |
| Brainstorm | Updates for Switzerland: +2985 cases (now 897078) since 22 hours ago — Bosnia and Herz.: +924 cases (now 260837), +29 deaths (now 11869), +13577 tests (now 1.3 million) since a day ago | 15:32 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Pelosi was the real holdout in drug-pricing talks; U.S. to pay $1 billion for more Merck Covid pills → https://www.statnews.com/pharmalot/2021/11/09/covid19-pelosi-merck-pfizer-biogen-alzheimers/ | 15:51 |
| Guest1185 | dTal: he's been reading shakespeare | 15:55 |
| Brainstorm | New from The Indian Express: World: Moderna seeks EU authorization for Covid-19 vaccine in young kids → https://indianexpress.com/article/world/moderna-eu-authorization-covid-19-vaccine-kids-7615253/ | 16:02 |
| momomo | Can someone explain what this means on this page? https://www.cdc.gov/mmwr/volumes/70/wr/mm7035e5.htm | 16:19 |
| momomo | Since the introduction of mRNA COVID-19 vaccines in the United States in December 2020, an elevated risk for myocarditis among mRNA COVID-19 vaccine recipients has been observed, particularly among males aged 12–29 years, with 39–47 expected cases of myocarditis, pericarditis, and myopericarditis per million second mRNA COVID-19 vaccine doses administered (6). A recent study from Israel reported that mRNA COVID-19 vaccination was associated with an | 16:19 |
| momomo | elevated risk for myocarditis (risk ratio = 3.24; 95% CI = 1.55–12.44); in the same study, a separate analysis showed that SARS-CoV-2 infection was a strong risk factor for myocarditis (risk ratio = 18.28, 95% CI = 3.95–25.12) (4). | 16:19 |
| momomo | What is a risk ratio of 3.24 ? | 16:20 |
| momomo | How many per thousand ? | 16:20 |
| Brainstorm | Updates for Chile: +1746 cases (now 1.7 million), +4 deaths (now 37883), +49894 tests (now 24.1 million) since 23 hours ago — Canada: +4758 cases (now 1.7 million), +44 deaths (now 29248) since 23 hours ago | 16:34 |
| lastshell | it depends of how young you are is more prone to young individuals | 16:42 |
| Brainstorm | New from r/WorldNews: worldnews: Dutch hospitals urge new measures as COVID-19 cases near record → https://old.reddit.com/r/worldnews/comments/qq5zz4/dutch_hospitals_urge_new_measures_as_covid19/ | 16:47 |
| Brainstorm | Updates for Jordan: +2577 cases (now 880943), +11 deaths (now 11156), +81186 tests (now 11.3 million) since 23 hours ago | 17:05 |
| lastshell | dr john c compare ivermectin vs pfizer pill https://youtu.be/ufy2AweXRkc | 17:06 |
| Brainstorm | New from COVID tweets: Global Health Strategies (@GHS): The cost of choosing to be unvaccinated. ⬇️ Singapore is ending free #COVID19 treatment for patients who are eligible to get vaccinated but refused to get the jab, the 🇸🇬 Health Ministry says. nytimes.com/2021/11/09/wor… → https://twitter.com/GHS/status/1458105401816268803 | 17:21 |
| lastshell | so ivermectin works, mild shock | 17:26 |
| Brainstorm | Updates for Netherlands: +11310 cases (now 2.3 million), +29 deaths (now 19054) since 23 hours ago | 17:30 |
| Brainstorm | New from Reddit (test): Tuesday 09 November 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://old.reddit.com/r/CoronavirusUK/comments/qq78a8/tuesday_09_november_2021_update/ | 17:33 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): I should mention that consistent use of an N95 is expected. → https://twitter.com/hjelle_brian/status/1458110955041157120 | 17:44 |
| Brainstorm | Updates for Greece: +8969 cases (now 801208), +53 deaths (now 16414), +636213 tests (now 28.5 million) since a day ago — Greenland: +40 cases (now 922), +2105 tests (now 92340) since 16 hours ago | 18:07 |
| Dredd | <sdfgsdfg> "so you look at the alpha and..." <- No, it's survival of the fittest | 18:07 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The randomized trial of the Pfizer vaccine for children age 5-11 is published @NEJM today. The data indicate very high efficacy (91%, 95% CI 68,98)) a strong immune response and absence of any serious side effects among 2,268 participants nejm.org/doi/full/10.10… [... want %more?] → https://twitter.com/EricTopol/status/1458117183771496455 | 18:08 |
| lastshell | guys did you saw the ivermectin last studies shows works the same as the new pfizer pill ? | 18:11 |
| Dredd | <lastshell> "so ivermectin works, mild shock..." <- Eh, there's been a lot of studies and overall it doesn't work | 18:11 |
| Dredd | This guy, I don't think much of him personally, is saying that the mechanism of action is the same | 18:11 |
| specing | get vaccinated and you wont care about ivermectin and pfizerpill | 18:12 |
| specing | :) | 18:12 |
| Dredd | That's like saying that all SSRIs work the same but the reality is different people get on with different ones better / worse etc | 18:12 |
| Dredd | So it's not quite so simple (caveat I don't have time to watch the full video now) | 18:12 |
| lastshell | what about breaktrouh cases ? | 18:12 |
| Dredd | But he seems to be referencing a computer simulation too | 18:13 |
| Dredd | de-facto may have time, and willingness, to go into details more | 18:13 |
| Dredd | Analyse more fully etc | 18:13 |
| lastshell | dr john talks about some c3l but Im not very well verse in the covid terms | 18:14 |
| lastshell | something about block some protein | 18:15 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): COVID spokesvirus: Your kids aren't gonna get that sick and die just now? Got it covered. pic.twitter.com/DM2I76xqcl → https://twitter.com/hjelle_brian/status/1458119002945847300 | 18:19 |
| Dredd | Has this guy moved more into fringe stuff these days? | 18:20 |
| Dredd | He seems to be very focused on some very wide binding affinity analyses of ivermectin, he doesn't actually seem to have provided compelling evidence that ivermectin actually works (which has been shown not to) | 18:24 |
| Dredd | The Pfizer drug appears to work (though at this point since it isn't generally available we only really have the pfizer studies for now) | 18:24 |
| Dredd | When it's in wider use we'll get more impartial stuff to look at | 18:25 |
| Dredd | Now he's talking about binding to ACE2 rather than inhibiting proteases? Or is that how it works? That's not what he says? | 18:26 |
| Dredd | Ah, right he's saying ivermectin also does these other things | 18:26 |
| Dredd | I wasn't a fan of this guy before he appears to have gone all fringe conspiracy, definitely not now | 18:27 |
| Dredd | He should know better than this as a doctor | 18:27 |
| Dredd | Seems like he's cashing in on the popularity of these theories to me ☹️ | 18:28 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The neutralizing antibody response for 5-11 years olds vs 16-25 years olds at 1/3rd the dose (and compared with placebo)nejm.org/doi/suppl/10.1… pic.twitter.com/4tTHQN82HQ → https://twitter.com/EricTopol/status/1458122130533466116 | 18:30 |
| Brainstorm | Updates for Italy: +6543 cases (now 4.8 million), +63 deaths (now 132491), +894804 tests (now 108.2 million) since 21 hours ago — Dominican Rep.: +968 cases (now 390058), +1 deaths (now 4154), +6889 tests (now 2.3 million) since 23 hours ago — Qatar: +138 cases (now 240385), +5064 tests (now 2.9 million) since a day ago | 18:32 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): There should be a great deal of suspicion whenever one hears of a drug repurposed from the world of parasitic worms or malaria that is now supposed to take on a completely unrelated kind of creature. We are FAR more related to (say) pine trees than [... want %more?] → https://twitter.com/hjelle_brian/status/1458125339985514498 | 18:41 |
| Dredd | .title https://www.medscape.com/viewarticle/962222?uac=66555DT&faf=1&sso=true&impID=3774109&src=WNL_trdalrt_pos1_211106 | 18:50 |
| Brainstorm | Dredd: From www.medscape.com: Ivermectin-COVID-19 Study Retracted; Authors Blame File Mixup | 18:50 |
| Dredd | > was found to have blocks of details of 11 patients that had been copied and pasted repeatedly – suggesting many of the trial’s apparent patients didn’t really exist. | 18:51 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Two new reports serve as a foundation for a covid kids vaccine checklistnejm.org/doi/full/10.10… on efficacy and safetymedrxiv.org/content/10.110… 2 unvaccinated children (G1) seed an outbreak of 246 people pic.twitter.com/6kCje5wEFA → https://twitter.com/EricTopol/status/1458129699566014467 | 18:53 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): For its FB page, COVID spokesvirus is asking for your explanation of "why it's OK now to travel and go to maskless parties"."We want HAPPY talk! Tell us how you were deprived and now deserve #Freedumb! Way too much on dead people!" pic.twitter.com/Du8Uy1p6VQ → https://twitter.com/hjelle_brian/status/1458129920077430786 | 19:04 |
| Dredd | Lol, I think I'm right about Dr Campbell's viewer base... | 19:06 |
| * Dredd uploaded an image: (31KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/COuzVOfCviIkHTFHMUlaVXkq/image.png > | 19:06 | |
| lastshell | thank you Dredd | 19:10 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): I understand the urgency in solving long COVID, but effective therapies will take longer to find than those that reduce acute mortality, and might well not be the same drugs. The issues include whether actual viral persistence is needed for long COVID. → https://twitter.com/hjelle_brian/status/1458135194926346245 | 19:15 |
| Dredd | <lastshell> "thank you Peter" <- No worries, it's just my opinions / view of it - it would in many ways be good if he was right as ivermectin is indeed cheap but sadly it is not much use | 19:24 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): So we assume clearance of a mysterious new RNA agent like SARS2 after we can no longer detect its RNA in our snot or its symptoms at our own peril.We can't prove it doesn't persist.END → https://twitter.com/hjelle_brian/status/1458140636058558468 | 19:37 |
| Brainstorm | Updates for United Kingdom: +33031 cases (now 9.4 million), +262 deaths (now 142555) since 23 hours ago — Germany: +25706 cases (now 4.8 million) since 22 hours ago — Luxembourg: +185 cases (now 83479), +1 deaths (now 852), +2641 tests (now 3.6 million) since a day ago — Maldives: +160 cases (now 89126), +1 deaths (now 246), +4483 tests (now 1.6 million) since 23 hours ago | 19:40 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Misinformation is a killer. Not just in the United States.What has fueled the world's outlier in Covid deaths?nytimes.com/2021/11/08/wor… @ATHigginsNYT (where it is classified as a criminal offense) pic.twitter.com/6lu33903o4 → https://twitter.com/EricTopol/status/1458141186716147717 | 19:48 |
| Brainstorm | New from Retraction Watch: Bad MATH+? Covid treatment paper by Pierre Kory retracted for flawed results: A Wisconsin physician who has been pushing unproven treatments for Covid-19 has lost a paper on a hospital protocol his group says radically reduced deaths [... want %more?] → https://retractionwatch.com/2021/11/09/bad-math-covid-treatment-paper-by-pierre-kory-retracted-for-flawed-results/ | 20:32 |
| Brainstorm | New from CIDRAP: News Scan for Nov 09, 2021: SARS-CoV-2-like coronavirus in bats Global flu stays low Probable DRC Ebola cases → https://www.cidrap.umn.edu/news-perspective/2021/11/news-scan-nov-09-2021 | 20:44 |
| Brainstorm | Updates for India: +1845 cases (now 34.4 million), +22 deaths (now 461411) since 13 hours ago — Kuwait: +24 cases (now 412893), +15101 tests (now 5.0 million) since 22 hours ago | 21:14 |
| Brainstorm | New from BioNTech: Pfizer and BioNTech Submit Request to Amend U.S. FDA Emergency Use Authorization of Their COVID-19 Vaccine Booster to Include All Individuals 18 and Older: Submission is based on efficacy and safety data from a Phase 3 [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-submit-request-amend-us-fda-emergency-use | 21:17 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): "Our data demonstrate the importance of booster doses to maintain protection in the elderly and clinically vulnerable and suggest that these should be prioritized to those who received ChAdOx1 [AZ vaccine] as their primary course." → https://twitter.com/EricTopol/status/1458167894496346113 | 21:28 |
| Brainstorm | Updates for Sudan: +586 cases (now 41019) since 15 days ago — France: +12565 cases (now 7.3 million), +46 deaths (now 118970) since 23 hours ago — Netherlands: +11316 cases (now 2.3 million) since 23 hours ago | 21:39 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): About timing:"Our results show waning to levels associated with breakthrough infections before this 6 month period for those vaccinated with ChAdOx1 but not for BNT162b2." → https://twitter.com/EricTopol/status/1458172855707832324 | 21:50 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.11.05.21265968v1 | 21:57 |
| Brainstorm | de-facto: From www.medrxiv.org: Waning of SARS-CoV-2 antibodies targeting the Spike protein in individuals post second dose of ChAdOx1 and BNT162b2 COVID-19 vaccines and risk of breakthrough infections: analysis of the Virus Watch community cohort. | medRxiv | 21:57 |
| de-facto | "24049 samples from 8858 individuals (5549 who received a second dose of ChAdOx1 and 3205 BNT162b2) who remained anti-N negative were included in the analysis of anti-S waning over time." | 21:58 |
| de-facto | "Three weeks after the second dose of vaccine BNT162b2 mean anti-S levels were 9039 (95%CI: 7946-10905) U/ml and ChadOx1 were 1025 (95%CI: 917-1146) U/ml. For both vaccines, waning anti-S levels followed a log linear decline from three weeks after the second dose of vaccination." | 21:59 |
| de-facto | "At 20 weeks after the second dose of vaccine, the mean anti-S levels were 1521 (95%CI: 1432-1616) U/ml for BNT162b2 and 342 (95%CI: 322-365) U/ml for ChadOx1." | 21:59 |
| de-facto | "We identified 197 breakthrough infections and found a reduced risk of infection post second dose of vaccine for individuals with anti-S levels greater than or equal to 500 U/ml compared to those with levels under 500 U/ml (HR 0.62; 95%CIs:0.44-0.87; p=0.007). Time to reach an anti-S threshold of 500 U/ml was estimated at 96 days for ChAdOx1 and 257 days for BNT162b2." | 21:59 |
| de-facto | "We found an increased risk of a breakthrough infection for those who received the ChAdOx1 compared to those who received BNT162b2 (OR: 1.43, 95% CIs:1.18-1.73, p<0.001). " | 22:00 |
| de-facto | interestingly their figure 1 shows similar slope for the linear decay on log graph | 22:03 |
| de-facto | just with an offset (higher level for BNT vs AZ) and a bit steeper slope of decay for BNT in the first 10 weeks or such | 22:03 |
| de-facto | so pretty much as i suspected the sum of two exponentials | 22:04 |
| de-facto | one faster decaying and one slower decaying | 22:04 |
| Brainstorm | New from Contagion Live: The State of COVID-19 Testing: Where Are We Now?: COVID-19 testing has been an integral part of our country’s strategy to limit disease transmission. Here’s the latest information on types of tests, when they’re appropriate to use, and what they realistically [... want %more?] → https://www.contagionlive.com/view/the-state-of-covid-19-testing-where-are-we-now- | 22:12 |
| lastshell | de-facto so 3 months vs 8.5 months diff between AZ and Pfizer ? | 22:19 |
| lastshell | the inmunity last ? | 22:19 |
| Brainstorm | New from COVID tweets: Marc Veldhoen (@Marc_Veld): Once more an excellent explanation of the many incorrect information stories and advice about vaccines and the strange and detrimental politicisation of personal and community health. Follow the science.@Debunk_the_Funk youtu.be/isP6waOEp2U → https://twitter.com/Marc_Veld/status/1458181481751322634 | 22:23 |
| de-facto | lastshell, for their endpoint of 500U/ml yeah | 22:25 |
| Brainstorm | Updates for Germany: +26097 cases (now 4.8 million) since 22 hours ago | 22:34 |
| de-facto | "There was evidence that rates of waning were higher in BNT162b2 (-8.27e-03 [ln(anti-S U/ml)/day], t 1⁄2 = 68.81 days) than ChAdOx1 (-10.1e-03 [ln(anti-S U/ml)/day], t 1⁄2 = 84.5 days; p<0.001)." | 22:46 |
| de-facto | hmm i wonder what part of their graph they used for that, i guess the middle one to maximize accuracy of their fit (the linear decay on log graph) | 22:47 |
| de-facto | so i assume between 10 and 20 weeks post completing 2nd dose | 22:49 |
| Brainstorm | New from CIDRAP: Long COVID symptoms may have causes other than SARS-CoV-2: Mary Van Beusekom | News Writer | CIDRAP News Nov 09, 2021 The data underscore the importance of weighing all possible causes, including COVID-19. → https://www.cidrap.umn.edu/news-perspective/2021/11/long-covid-symptoms-may-have-causes-other-sars-cov-2 | 22:57 |
| de-facto | dangit we urgently need to have a better definition of long-COVID | 23:09 |
| LjL-Matrix | Paxlovid: "In November 2021, Pfizer announced positive phase 2/3 results, including 89% reduction in hospitalizations when given within three days after symptom onset.[7]" - Forgive me if I'm missing known/discussed things but I've been unplugged from COVID stuff for the past several days... This sounds extremely encouraging, but also if this effectiveness is only when given within three days (for all I know it could work after longer, and | 23:58 |
| LjL-Matrix | that was just the study standard, but I dunno), then I think one would have to be extremely quick in deciding to get a COVID test when symptoms arise, and PCR isn't quite immediate with results, so 3 days is probably unlikely in practice | 23:58 |
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