| Brainstorm | Updates for Colombia: +2367 cases (now 5.0 million), +30 deaths (now 127640), +46273 tests (now 27.2 million) since 23 hours ago — Argentina: +1567 cases (now 5.3 million), +19 deaths (now 116184), +46631 tests (now 25.5 million) since a day ago — Rwanda: +19 cases (now 100019), +13774 tests (now 3.2 million) since a day ago | 00:05 |
|---|---|---|
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): @hjelle_brian N501Y means we need a murine serosurvey. → https://twitter.com/fitterhappierAJ/status/1458573972447039492 | 00:25 |
| Brainstorm | New from The Lancet (Online): [Comment] Global surveillance, research, and collaboration needed to improve understanding and management of long COVID: The scale of chronic ill health and disability after COVID-19 has been described as the next big global health challenge.1 Prevalence [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02444-2/fulltext | 00:36 |
| Brainstorm | Updates for Cayman Is.: +751 cases (now 3427) since 4 days ago — Gibraltar: +50 cases (now 6256), +1205 tests (now 394728) since a day ago — Faroe Is.: +47 cases (now 2778), +3000 tests (now 517000) since a day ago | 01:01 |
| Brainstorm | New from Ars Technica: Science: White House hails vaccine mandates as number of unvaccinated drops 40% → https://arstechnica.com/ | 01:29 |
| Brainstorm | Updates for Bulgaria: +3853 cases (now 646856), +199 deaths (now 25754), +39229 tests (now 6.0 million) since 23 hours ago — Barbados: +335 cases (now 21011), +4 deaths (now 187), +2078 tests (now 407217) since 23 hours ago | 01:32 |
| Brainstorm | New from COVID tweets: Matthias Schmid🇬🇧🇩🇪🇪🇺👨⚕️💜 (@MatthiasUK): This is an important piece of work as we need good evidence on use of #antivirals and #nMABs in immunesuppressed patients with prolonged/persistant #Covid19. @chrisjaduncan @viraldoc @NewcastleHosps @NHSEngland twitter.com/VirusesImmunit… → https://twitter.com/MatthiasUK/status/1458589929194364929 | 01:49 |
| Brainstorm | New from r/WorldNews: worldnews: France experiencing start of fifth wave of COVID epidemic -minister → https://old.reddit.com/r/worldnews/comments/qr8kwp/france_experiencing_start_of_fifth_wave_of_covid/ | 02:00 |
| Brainstorm | Updates for Uruguay: +195 cases (now 395805), +9817 tests (now 3.9 million) since 23 hours ago — Qatar: +172 cases (now 240557), +5761 tests (now 2.9 million) since a day ago — Paraguay: +54 cases (now 461520), +1879 tests (now 1.9 million) since 23 hours ago | 02:09 |
| Brainstorm | New from COVID tweets: Tereena Lucas (@TereenaLucas): ‘…study illustrates that in this immunocompromised person, endogenous immune responses were unable to control the virus, and that remdesivir resistance arose while on treatment. Monoclonal Abs were effective in clearing persistent virus and restoring sense [... want %more?] → https://twitter.com/TereenaLucas/status/1458601352611827714 | 02:21 |
| Brainstorm | Updates for United Kingdom: +39436 cases (now 9.5 million) since 17 hours ago | 02:34 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The imminent anti-Covid pills, which have considerable promise to help us prevail over the pandemicSummary nature.com/articles/d4158… @heidiledford @nature Added a Table row to account for the cytochrome interactions with common drugs for the Pfizer drug combo (due [... want %more?] → https://twitter.com/EricTopol/status/1458607826515890176 | 02:42 |
| Brainstorm | Updates for Guadeloupe: +183 cases (now 54920), +13179 tests (now 536488) since 20 hours ago | 02:59 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Note that the drug interactions with Pfizer's pills are readily circumvented, since it's only a 5-day treatment course (you can read the linked piece) → https://twitter.com/EricTopol/status/1458613931711156234 | 03:03 |
| Brainstorm | Updates for Gabon: +257 cases (now 36587), +3 deaths (now 262), +9637 tests (now 1.4 million) since a day ago — Brunei: +57 cases (now 13962), +8980 tests (now 544282) since 7 hours ago — S. Sudan: +13 cases (now 12546), +1116 tests (now 255771) since 7 hours ago | 03:36 |
| Brainstorm | Updates for Peru: +1238 cases (now 2.2 million), +30 deaths (now 200532), +49882 tests (now 19.5 million) since 21 hours ago — Panama: +185 cases (now 473903), +6748 tests (now 4.1 million) since 21 hours ago — Guinea-Bissau: +53 cases (now 6203), +356 tests (now 104176) since 5 days ago | 04:01 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In July, we reported prolonged impact of Covid on resting heart rate and other physiologic parameters, a window into #LongCovid. jamanetwork.com/journals/jaman…Now that finding has been fully and independently replicated in Germany @rki_de [... want %more?] → https://twitter.com/EricTopol/status/1458632059790839809 | 04:17 |
| Brainstorm | Updates for United Kingdom: +39553 cases (now 9.5 million) since 20 hours ago — Netherlands: +12685 cases (now 2.3 million) since 20 hours ago | 04:38 |
| Brainstorm | New from r/Science: science: How COVID Might Sow Chaos in the Brain → https://old.reddit.com/r/science/comments/qrbh9f/how_covid_might_sow_chaos_in_the_brain/ | 04:48 |
| Brainstorm | Updates for Germany: +51073 cases (now 4.9 million) since 19 hours ago — Belgium: +14586 cases (now 1.5 million), +31 deaths (now 26261), +106909 tests (now 22.6 million) since 19 hours ago | 05:40 |
| Brainstorm | New from The Indian Express: World: Moderna Covid-19 vaccine patent dispute headed to court, US NIH Head says → https://indianexpress.com/article/world/moderna-covid-vaccine-patent-dispute-court-us-nih-7617703/ | 06:01 |
| Brainstorm | Updates for India: +13091 cases (now 34.4 million), +340 deaths (now 462189) since 22 hours ago | 06:05 |
| Brainstorm | Updates for Saxony, Germany: +6354 cases (now 360626), +50 deaths (now 10473) since 23 hours ago — Poltava Oblast, Ukraine: +1591 cases (now 108681), +45 deaths (now 2621) since 23 hours ago — Mykolaiv Oblast, Ukraine: +1067 cases (now 93933), +35 deaths (now 2608) since 23 hours ago — Lombardy, Italy: +1073 cases (now 901003), +5 deaths (now 34210) since 23 hours ago | 06:30 |
| Brainstorm | Updates for Kyrgyzstan: +108 cases (now 182090), +3 deaths (now 2697), +3135 tests (now 1.8 million) since 23 hours ago | 07:08 |
| Brainstorm | New from The Indian Express: World: Biden invokes India, Brazil to explain global supply chain disruptions due to Covid-19 → https://indianexpress.com/article/world/biden-invokes-india-brazil-to-explain-global-supply-chain-disruptions-due-to-covid-19-7617825/ | 07:47 |
| Brainstorm | Updates for Georgia: +4563 cases (now 771381), +77 deaths (now 10739), +49334 tests (now 10.7 million) since 23 hours ago | 08:35 |
| Brainstorm | New from COVID tweets: Marc Veldhoen (@Marc_Veld): theconversation.com/vaccine-trial-… → https://twitter.com/Marc_Veld/status/1458701251797999617 | 08:49 |
| Brainstorm | Updates for Czechia: +13536 cases (now 1.9 million), +60 deaths (now 31289), +217914 tests (now 41.6 million) since 23 hours ago | 08:59 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | November 11, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/qrg9wk/daily_discussion_thread_november_11_2021/ | 09:10 |
| Brainstorm | New from The Indian Express: World: From Russia to Germany: Countries battling surge in Covid cases → https://indianexpress.com/article/world/countries-battling-covid-surges-europe-7617955/ | 09:21 |
| Brainstorm | Updates for Armenia: +1482 cases (now 325521), +36 deaths (now 6867), +13310 tests (now 2.2 million) since a day ago — Netherlands: +69 cases (now 2.3 million) since 15 hours ago — Taiwan: +9 cases (now 16465), +115579 tests (now 7.8 million) since 22 hours ago | 09:37 |
| Brainstorm | New from BBC Health: University of Oxford starts new Ebola vaccine trials: Clinical trials are under way for a new Ebola vaccine developed by the University of Oxford. → https://www.bbc.co.uk/news/uk-england-oxfordshire-59245679 | 09:53 |
| Brainstorm | Updates for Hungary: +8394 cases (now 931414), +132 deaths (now 31751), +37624 tests (now 7.7 million) since 23 hours ago — Lithuania: +2657 cases (now 436690), +37 deaths (now 6251), +22378 tests (now 5.8 million) since 23 hours ago | 10:02 |
| Brainstorm | New from Politico: New coronavirus cases top 50,000 in Germany for the first time: Record comes as coalition hopefuls face criticism for COVID-19 measures to be debated in parliament. → https://www.politico.eu/article/new-coronavirus-cases-top-50000-in-germany-for-the-first-time/ | 10:14 |
| Brainstorm | New from r/WorldNews: worldnews: Germany records 50,000 COVID-19 cases in ‘dramatic’ virus surge → https://old.reddit.com/r/worldnews/comments/qrha5e/germany_records_50000_covid19_cases_in_dramatic/ | 10:24 |
| Brainstorm | Updates for Estonia: +1271 cases (now 209597), +13 deaths (now 1650), +7844 tests (now 2.2 million) since 22 hours ago — Papua New Guinea: +99 cases (now 32378), +5260 tests (now 224212) since 22 hours ago | 10:39 |
| imaginary | +13.5k in czechia :( | 10:43 |
| undefined_bob | they are not doing good :( | 10:44 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Comirnaty, Tozinameran,COVID-19 mRNA Vaccine (nucleoside modified), COVID-19 virus infection, Date of authorisation: 21/12/2020, Revision: 14, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/comirnaty | 10:46 |
| imaginary | yeah, no one really wears masks out door here but they do indoors so i guess that counts for something | 10:46 |
| imaginary | these next few weeks are gonna be rough | 10:47 |
| imaginary | outdoors* | 10:47 |
| rpifan | so when are we getting novavax | 10:52 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Spikevax (previously COVID-19 Vaccine Moderna), COVID-19 mRNA Vaccine (nucleoside modified), COVID-19 virus infection, Date of authorisation: 06/01/2021, Revision: 14, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/spikevax | 10:57 |
| SpearRaven | when is the next pandemic release date? a more virulent strain of some other CRISPR virus | 10:58 |
| SpearRaven | Pfizer working on that to make more money yet? Mainstream media briefed yet? News ready to be quashed on existing medications that might help like Ivermectin was? | 11:00 |
| SpearRaven | death = $$$ in the Pharmacology world ;-) | 11:01 |
| undefined_bob | not sure if troll or just ... | 11:03 |
| Brainstorm | Updates for Austria: +11975 cases (now 923150), +24 deaths (now 11601), +725954 tests (now 102.2 million) since a day ago — Slovakia: +6546 cases (now 540209), +38 deaths (now 13405), +22967 tests (now 4.2 million) since 23 hours ago | 11:04 |
| SpearRaven | hey undefined_bob hows it goin | 11:04 |
| undefined_bob | I'm not sure yet SpearRaven. but how are you doing? | 11:05 |
| SpearRaven | ok mate, getting stuck into my Stout with a bit of Whiskey added | 11:05 |
| undefined_bob | yesterday I cut in my finger. It burns :( | 11:05 |
| SpearRaven | suck it | 11:06 |
| SpearRaven | that my medical advice .. haha | 11:06 |
| undefined_bob | it burns everytime I wash my hands and it burns even more when I use hand sanitizer :( | 11:07 |
| SpearRaven | might take a few days to sort itself out | 11:07 |
| undefined_bob | I cut it with a mini angle grinder | 11:07 |
| SpearRaven | oh ok | 11:07 |
| undefined_bob | aua aua | 11:07 |
| undefined_bob | I was cutting a thick wire | 11:08 |
| SpearRaven | maybe didn't use the right tool | 11:08 |
| undefined_bob | the best I had | 11:08 |
| undefined_bob | it was like a steel rope | 11:08 |
| SpearRaven | i often have to resort to using improper tools to do things | 11:08 |
| SpearRaven | yeah | 11:09 |
| undefined_bob | as thick as my pinkie finger | 11:09 |
| SpearRaven | oh ok, either what you used then or some heavy duty bolt cutter | 11:09 |
| undefined_bob | I made a rope out of it for a hanging flower plot | 11:09 |
| SpearRaven | aha for the missus? | 11:10 |
| undefined_bob | yes, the large bolt cutter would be perfect but I have only small ones | 11:10 |
| undefined_bob | noo for my self and my cute plant | 11:10 |
| SpearRaven | yeah i know, we all do it | 11:10 |
| undefined_bob | btw can I have a Stout with some Whiskey too, please? | 11:11 |
| * darsie offers Obstler to undefined_bob. | 11:17 | |
| darsie | https://de.wikipedia.org/wiki/Obstbrand | 11:18 |
| undefined_bob | thanks darsie :3 | 11:25 |
| undefined_bob | prost | 11:25 |
| SpearRaven | sure but you would have to get it yourself undefined_bob | 11:37 |
| SpearRaven | im not going anywhere and my borders are hard stopped | 11:37 |
| SpearRaven | like Poland | 11:37 |
| SpearRaven | I can only provide instruction | 11:38 |
| Brainstorm | Updates for Poland: +19079 cases (now 3.2 million), +274 deaths (now 78524) since a day ago — France: +11923 cases (now 7.3 million), +34 deaths (now 119004) since 22 hours ago — Germany: +50442 cases (now 4.9 million) since 21 hours ago | 11:41 |
| SpearRaven | are slaughterbots next? | 11:46 |
| SpearRaven | https://www.youtube.com/watch?v=O-2tpwW0kmU | 11:46 |
| SpearRaven | maybe i should start manufacturing them ? what a service ? | 11:53 |
| SpearRaven | https://www.youtube.com/watch?v=2sky1tt8vLA | 11:53 |
| Brainstorm | New from COVID tweets: John Burn-Murdoch (@jburnmurdoch): If we look at critical-care beds only, you can see how the dynamics play out.Hospitals can repurpose general beds for ICU, but not without cost. Capacity for non-Covid critical-care patients was halved last winter due to the Covid wave. pic.twitter.com/38Svyn4G2o → https://twitter.com/jburnmurdoch/status/1458748662356529153 | 12:00 |
| Brainstorm | Updates for Finland: +863 cases (now 167119), +4 deaths (now 1216), +21184 tests (now 7.6 million) since 23 hours ago | 12:06 |
| Brainstorm | New from Il Sole 24 Ore: Tra i sanitari più contagi e flop terze dosi: ecco perché tornerà l’obbligo al vaccino: Il Governo si prepara a prorogare l’obbligo vaccinale per i sanitari e il personale che lavora nelle Rsa, che riguarderà dunque anche [... want %more?] → https://www.ilsole24ore.com/art/tra-sanitari-piu-contagi-e-flop-terze-dosi-ecco-perche-tornera-l-obbligo-vaccino-AEMS8Gw | 12:10 |
| undefined_bob | SpearRaven: so you won't share with me? :( | 12:19 |
| SpearRaven | sorry mate .. as above | 12:21 |
| Brainstorm | Updates for United Kingdom: +919 cases (now 9.5 million) since 16 hours ago — Indonesia: +435 cases (now 4.2 million), +16 deaths (now 143608), +262028 tests (now 49.4 million) since 23 hours ago — Nepal: +301 cases (now 816060), +6 deaths (now 11466), +9609 tests (now 4.5 million) since 23 hours ago | 12:31 |
| Brainstorm | New from ECDC: Data on testing for COVID-19 by week and country: The downloadable data file contains information about testing volume for COVID-19 by week and country. Each row contains the corresponding data for a country and a week. The file is updated weekly. You may use the data in line with ECDC’s [... want %more?] → https://www.ecdc.europa.eu/en/publications-data/covid-19-testing | 12:32 |
| Brainstorm | New from ECDC: ECDC: Data for the maps in support of the Council Recommendation on a coordinated approach to the restriction of free movement in response to the COVID-19 pandemic in the EU/EEA → https://www.ecdc.europa.eu/en/publications-data/indicators-maps-support-council-recommendation | 12:42 |
| Brainstorm | New from ScienceNews: No, COVID-19 vaccines won’t make you infertile: Contrary to misinformation spread by Aaron Rodgers and Nicki Minaj, neither the Pfizer, Moderna nor J&J vaccines cause infertility, data show. → https://www.sciencenews.org/article/covid-vaccine-infertility-pregnancy-false-information | 13:04 |
| Brainstorm | Updates for Zambia: +14 cases (now 209953), +4680 tests (now 2.6 million) since 22 hours ago — Senegal: +2 cases (now 73947), +1540 tests (now 853421) since 23 hours ago | 13:08 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Virologists all suffered thru a seemingly endless parade of potential live-attenuated HIV "vaccine strains" that took out more & more genes til was no virus left. Very disappointing that there was no happy spot, compromise between safety & efficacy. → https://twitter.com/hjelle_brian/status/1458768079408693254 | 13:14 |
| Brainstorm | New from Politico: Olaf Scholz urges German parliament to approve new coronavirus rules: Stuck in the transition period between two governments, Germany is grappling with its fourth coronavirus wave. → https://www.politico.eu/article/olaf-scholz-urges-german-parliament-to-approve-new-coronavirus-rules/ | 13:35 |
| Brainstorm | Updates for Uganda: +49 cases (now 126763), +3 deaths (now 3234), +6277 tests (now 1.9 million) since a day ago | 13:39 |
| Brainstorm | New from COVID tweets: John Burn-Murdoch (@jburnmurdoch): Excellent line from one of the scientists I spoke to for this story, re Covid culture wars in the UK and elsewhere:"We could still be doing better on masking, but if we’re going to have a Covid culture war, I’d prefer it around masking than [... want %more?] → https://twitter.com/jburnmurdoch/status/1458777110458339333 | 13:46 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Sweartadog, SARS2 is that long-lost experiment to a retired virologist, the one NIH didn't fund. "What happens when EVERY POSSIBLE THING that could happen between virus and humans plays out in real life"? It is a constant stream of data. → https://twitter.com/hjelle_brian/status/1458778478837256200 | 13:57 |
| Brainstorm | New from COVID tweets: John Burn-Murdoch (@jburnmurdoch): (I’m taking a break from Covid stats today by speaking at a sports analytics conference, and honestly this might now be my all-time favourite image) pic.twitter.com/hvmnR0QNjQ → https://twitter.com/jburnmurdoch/status/1458782730846625796 | 14:07 |
| Brainstorm | Updates for Vietnam: +8162 cases (now 1.0 million), +84 deaths (now 22849), +406901 tests (now 63.4 million) since a day ago — Latvia: +1378 cases (now 236765), +48 deaths (now 3646), +15562 tests (now 5.1 million) since a day ago — UAE: +82 cases (now 740729), +246170 tests (now 96.2 million) since 23 hours ago | 14:10 |
| Brainstorm | Updates for Croatia: +6987 cases (now 521837), +66 deaths (now 9721), +16448 tests (now 3.2 million) since a day ago — Germany: +50958 cases (now 4.9 million) since 23 hours ago | 14:35 |
| Brainstorm | New from Reddit (test): China_Flu: How SARS-CoV-2 in white-tailed deer could alter the course of the pandemic : Goats and Soda : NPR → https://old.reddit.com/r/China_Flu/comments/qrlhua/how_sarscov2_in_whitetailed_deer_could_alter_the/ | 14:49 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): 3. From waning to to rising antibody levels pic.twitter.com/BHX7o2cbqH → https://twitter.com/EricTopol/status/1458794141366689800 | 14:59 |
| Brainstorm | Updates for Belarus: +1981 cases (now 621689), +16 deaths (now 4805), +31490 tests (now 10.0 million) since a day ago | 15:06 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Just published @NatureMedicine An in-depth analysis of the 25 children who died from Covid in England during the 1st year of the pandemicnature.com/articles/s4159…Great that 99.995% of children w/ a positive test survived (not what is driving the need for 💉in [... want %more?] → https://twitter.com/EricTopol/status/1458797590271520771 | 15:10 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): Naar alle waarschijnlijkheid zou die daling er bij ons ook snel moeten komen, zeker gegeven onze hogere vaccinatiegraad (75% vs. 67% in VK), gebruik van een iets beter vaccin dat recenter toegediend werd (vooral Pfizer vs. vooral AZ) & hoge blootstelling tijdens [... want %more?] → https://twitter.com/TWenseleers/status/1458800163619811343 | 15:21 |
| Brainstorm | Updates for Switzerland: +3884 cases (now 905112) since 21 hours ago | 15:31 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: NIH to fight Moderna in court over Covid-19 vaccine patents; ‘puzzling’ results in an Alzheimer’s study → https://www.statnews.com/pharmalot/2021/11/11/covid19-vaccine-patents-nih-moderna-alzheimers-medicare-jobs/ | 15:31 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): If you are cleaning up a rodent-infested area, absolutely wear an N95. Air it out well first. Lysol or 10% bleach any nests, poops, dead mice before cleaning up- with gloves.#Hantavirus → https://twitter.com/hjelle_brian/status/1458811812464381960 | 16:03 |
| Brainstorm | New from COVID tweets: Prof. Shane Crotty (@profshanecrotty): My lecture on Immunity and Immune Memory to SARS2 infection and COVID vaccines, for the MIT course on COVID-19. Thanks to the great Prof. Facundo Batista and @MITBiology (my alma mater!) for the invite.youtu.be/5OguBUfcZoA → https://twitter.com/profshanecrotty/status/1458815937021235204 | 16:25 |
| Brainstorm | New from The Indian Express: World: Austrian leader says lockdown for the unvaccinated is likely → https://indianexpress.com/article/world/austria-covid-vaccination-lockdown-7618637/ | 16:35 |
| Brainstorm | Updates for Chile: +2733 cases (now 1.7 million), +22 deaths (now 37917), +83614 tests (now 24.3 million) since 23 hours ago — Canada: +2743 cases (now 1.7 million), +27 deaths (now 29305) since 23 hours ago | 16:40 |
| Brainstorm | Updates for Djibouti: +1 cases (now 13494), +435 tests (now 240557) since 2 days ago | 17:05 |
| Brainstorm | New from Contagion Live: Fighting C Difficile Infection during the COVID-19 Pandemic: Dr. Nicola Petrosillo discusses treating C difficile infection and maintaining antimicrobial stewardship during the height of the COVID-19 in Italy. → https://www.contagionlive.com/view/fighting-c-difficile-infection-during-the-covid-19-pandemic | 17:07 |
| Brainstorm | New from The Indian Express: World: Malaysia to reopen to international visitors by Jan 1: Govt council → https://indianexpress.com/article/world/malaysia-to-reopen-to-international-visitors-by-jan-1-govt-council-7618676/ | 17:17 |
| aradesh | the offloop covid site seems broken | 17:29 |
| aradesh | showing no data for me | 17:29 |
| Brainstorm | Updates for Netherlands: +16356 cases (now 2.3 million), +26 deaths (now 19105) since 23 hours ago — Greece: +6771 cases (now 815068), +67 deaths (now 16560), +344468 tests (now 29.2 million) since 23 hours ago — Greenland: +19 cases (now 982), +962 tests (now 94198) since 19 hours ago | 17:30 |
| Brainstorm | New from r/WorldNews: worldnews: Morgues fill up in Romania and Bulgaria amid low Covid vaccine uptake → https://old.reddit.com/r/worldnews/comments/qrpd6s/morgues_fill_up_in_romania_and_bulgaria_amid_low/ | 18:00 |
| Brainstorm | New from COVID tweets: Oliver Barnes (@mroliverbarnes): Don't normally do this but 🚨#journorequest🚨Since early October, 130k over-80s have come forward for their first Covid-19 vaccine dose in England. And many more in Wales, Scot and NI.I'm keen to speak to recently vaccinated over-80s in the UK for [... want %more?] → https://twitter.com/mroliverbarnes/status/1458841993421930502 | 18:10 |
| Brainstorm | New from BioNTech: Zipline, Pfizer and BioNTech Collaboration Paves the Way for Automated, On-Demand Delivery of First mRNA COVID-19 Vaccines in Ghana: Zipline successfully completes world’s first long-range drone delivery of vaccines requiring [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/zipline-pfizer-and-biontech-collaboration-paves-way-automated | 18:21 |
| Brainstorm | Updates for Dominican Rep.: +1119 cases (now 392223), +1 deaths (now 4158), +10033 tests (now 2.3 million) since 22 hours ago — Luxembourg: +243 cases (now 84069), +2 deaths (now 854), +3218 tests (now 3.6 million) since a day ago — United Kingdom: +972 cases (now 9.5 million) since 22 hours ago | 18:32 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): OK I admit I hadn't thought of GQP as an animal reservoir for SARS2 but like to think I woulda got there. twitter.com/Loki00715/stat… → https://twitter.com/hjelle_brian/status/1458856011897311236 | 19:03 |
| Brainstorm | Updates for Italy: +8697 cases (now 4.8 million), +67 deaths (now 132618), +595812 tests (now 109.3 million) since 23 hours ago | 19:09 |
| Brainstorm | New from WebMD: U.S. Postal Service Warns Vaccine Mandate Could Affect Deliveries: The U.S. Postal Service expressed concerns on Wednesday that the Biden administration’s vaccine mandate for large companies could affect deliveries. → https://www.webmd.com/vaccines/covid-19-vaccine/news/20211111/us-postal-service-vaccine-mandate-deliveries | 19:24 |
| Brainstorm | Updates for Maldives: +109 cases (now 89364), +1 deaths (now 247), +2907 tests (now 1.6 million) since 23 hours ago | 19:34 |
| de-facto | COVID Germany 2021-11-11: SARS-CoV-2 Infections 50196, COVID-Deaths 235, Weekly Incidence 249.1/100k/7d, Reproduction number Rt(4d) ~ 1.2, hence doubling time T2 = 4d Ln(2)/Ln(1.2) = 15.2d | 19:42 |
| Brainstorm | New from COVID tweets: John Burn-Murdoch (@jburnmurdoch): Great chart from @PaulMainwood showing that after months of waning, the protective effect of vaccines is rising again among England's over-70s, most of whom have received third doses over the last few weeks twitter.com/paulmainwood/s… → https://twitter.com/jburnmurdoch/status/1458870266981986314 | 19:55 |
| Brainstorm | Updates for Bangladesh: +237 cases (now 1.6 million), +1 deaths (now 27907), +19544 tests (now 10.5 million) since a day ago | 19:59 |
| de-facto | .title https://imgur.com/a/2VF7DBd https://i.imgur.com/ZU6KYje.png https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/Wochenbericht/Wochenbericht_2021-11-11.pdf?__blob=publicationFile | 20:03 |
| Brainstorm | de-facto: From imgur.com: COVID Germany: Weekly Incidence per age - Album on Imgur | 20:03 |
| Brainstorm | New from Contagion Live: Phase 3 Data Finds India’s BBV152 COVID-19 Vaccine Safe and Effective: 2 doses of the India-developed vaccine BBV152 offer 77.8% protection against symptomatic COVID-19 disease. → https://www.contagionlive.com/view/phase-3-data-finds-india-s-bbv152-covid-19-vaccine-safe-and-effective | 20:06 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): A year ago, Nov 9th, the 1st Covid vaccine was announced w/ >90% efficacy vs symptomatic infections, at 2 months follow-up, before the emergence α, β,γ and δ variantsToday, w/ a 3rd shot, there's still >90% efficacy vs Delta and risk of hospitalizations and [... want %more?] → https://twitter.com/EricTopol/status/1458873853417975828 | 20:17 |
| de-facto | .title https://imgur.com/a/MSxagy9 https://i.imgur.com/k6ejeFF.png src: https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/Wochenbericht/Wochenbericht_2021-11-11.pdf?__blob=publicationFile | 20:21 |
| Brainstorm | de-facto: From imgur.com: COVID Germany: Vaccinations per time by age group - Album on Imgur | 20:21 |
| Brainstorm | Updates for France: +193 cases (now 7.3 million), +5 deaths (now 119008) since 23 hours ago — Mali: +36 cases (now 16562), +1 deaths (now 582), +1032 tests (now 466784) since 21 hours ago | 20:36 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Great @ScienceVisuals showing the difference in mechanism between these 2 pills in the course of #SARSCoV2 replicationscience.org/content/articl…Paxlovid inhibits the main protease (Mpro) that creates other essential proteinsMolnupiravar induces lethal mutagenesis [... want %more?] → https://twitter.com/EricTopol/status/1458880992786071557 | 20:37 |
| Brainstorm | New from StatNews: Listen: Moderna v. NIH, psilocybin as a medicine, & the cultural intake of pharma CEOs: Who invented Moderna's Covid-19 vaccine? Can psychedelic medicines be mainstream? And who's going to run the FDA? All that and more on the latest episode of "The Readout [... want %more?] → https://www.statnews.com/2021/11/11/podcast-moderna-covid-vaccine-nih-psilocybin-depression/ | 21:19 |
| Brainstorm | New from StatNews: Pharma: STAT+: ‘A work in progress’: BioNTech’s CEO wants to widen Covid-19 vaccine access on his own terms → https://www.statnews.com/pharmalot/2021/11/11/covid19-vaccine-booster-africa-sahin-biontech-pfizer/ | 21:30 |
| Brainstorm | Updates for India: +1526 cases (now 34.4 million), +180 deaths (now 462369) since 15 hours ago — Canada: +1709 cases (now 1.7 million) since 23 hours ago — Kuwait: +20 cases (now 412936), +14855 tests (now 5.0 million) since 23 hours ago | 21:38 |
| elephpant[m] | LjL offloop.net/covid19 isn't fetching data | 21:55 |
| LjL-Matrix | elephpant: thanks, I can confirm that. I'll tell the site owner but I'm afraid he wasn't interested in the website anymore, which is too bad but his choice. Anyway I'll let him know | 21:55 |
| elephpant[m] | do you use a similar site? | 21:55 |
| LjL-Matrix | I use a site for my country's data sometimes, but my go-to site is offloop in general | 22:00 |
| LjL-Matrix | It was working like... two days ago | 22:01 |
| LjL-Matrix | There are definitely other sites with worldwide data but I had gotten quite used to the offloop graphs | 22:01 |
| LjL-Matrix | One you can try that has broad coverage of subregions is Covidly | 22:01 |
| elephpant[m] | offloop is my fav too :( | 22:01 |
| Brainstorm | New from r/WorldNews: worldnews: Germany was once praised for its Covid response. Now it’s seeing 50,000 cases a day, prompting a dramatic warning → https://old.reddit.com/r/worldnews/comments/qrukx5/germany_was_once_praised_for_its_covid_response/ | 22:02 |
| LjL-Matrix | Its data don't always match official data though, like, in the long term they do, but on a daily basis they aren't always "synced" | 22:02 |
| elephpant[m] | hopefully he fixes it! | 22:03 |
| LjL-Matrix | Also, the github page in the room topic has other trackers listed | 22:03 |
| Brainstorm | Updates for Spain: +4286 cases (now 5.0 million), +30 deaths (now 87647) since a day ago | 22:03 |
| LjL-Matrix | Tbh my preference in the past few weeks has been... not to look at the data too much :/ | 22:04 |
| elephpant[m] | i check once every like 2 weeks | 22:04 |
| TurboTech | Hello Guys | 22:07 |
| elephpant[m] | hi | 22:12 |
| elephpant[m] | what's the latest on whether booster shots are beneficial for not old people? | 22:12 |
| TurboTech | Not sure | 22:13 |
| TurboTech | However we are starting to see more northern places pick up the virus again. | 22:14 |
| elephpant[m] | I see that they're recommended for a few groups | 22:20 |
| elephpant[m] | but haven't found anything for people not in those groups (not old, not immunocompromised) | 22:22 |
| Brainstorm | New from CIDRAP: India's COVID vaccine shown 78% effective in phase 3 trial: Mary Van Beusekom | News Writer | CIDRAP News Nov 11, 2021 Two doses offer 77.8% efficacy against symptomatic COVID-19 but about 65% against the Delta variant. → https://www.cidrap.umn.edu/news-perspective/2021/11/indias-covid-vaccine-shown-78-effective-phase-3-trial | 22:23 |
| TurboTech | Our numbers here in Texas are going down. | 22:24 |
| TurboTech | I think the norther States are about to get hammered. | 22:24 |
| LjL-Matrix | Protection wanes, it may wane faster for older people but it does for everyone, honestly faster than I was hoping for | 22:30 |
| LjL-Matrix | They've quickly moved from "80+ and vulnerably only" to "everyone 60+" and as of today "everyone 40+" here | 22:30 |
| LjL-Matrix | I expect it to get lower as they have vaccine availability | 22:30 |
| lastshell | TurboTech probably because those states spend more time indoors | 22:36 |
| Brainstorm | Updates for Rwanda: +28 cases (now 100047), +1 deaths (now 1336), +6845 tests (now 3.3 million) since 22 hours ago | 22:41 |
| elephpant[m] | <LjL-Matrix> "They've quickly moved from "80..." <- if someone is 42, not immunocompromised, no sig underlying health problems, is there a benefit to a 3rd shot? | 22:43 |
| elephpant[m] | antibodies fade, but afaik the immune system remembers still | 22:44 |
| LjL-Matrix | elephpant: one hypothesis I've seen is that Delta reproduces too quickly for the immune system to start producing antibodies in time (keep in mind the second and more severe phase of the disease is an immune system mess, so if the virus is "caught" late there may not really be a benefit in catching it), which means we'll always have to keep antibodies circulating | 22:47 |
| de-facto | there are neutralizing antibodies, they peak about 2 weeks after completing primary vaccination series and then their concentration in the serum follows an exponential decay function that may have a half life of about 60-70 days or such | 22:47 |
| LjL-Matrix | I don't know if that's true, it was just one virologist's hypothesis | 22:47 |
| LjL-Matrix | I can tell you what I will do being a similar age, doesn't mean that's necessarily what you should do as well... When the third shot becomes available to me, I'll take it | 22:48 |
| de-facto | those antibodies are produced by the B-cells, some of which will become residual in the bone marrow and will spend very long time there, but only produce antibodies at very low concentrations, so they may contribute another exponential decay but with much longer half life (i have not seen data on that yet) | 22:49 |
| elephpant[m] | okay it seems like theory here would suggest getting a booster every 6 months or so | 22:50 |
| de-facto | then there are the T-cells, they will "shred" the antigen into tiny pieces hence remember those small pieces of the antigen, most of which will not change, only a few may change with antigenic drift | 22:50 |
| de-facto | those T-cells will go ahead and alarm the immune system by secreting chemical signals "cytokines" once they see occurrence of some parts of that antigen again | 22:51 |
| elephpant[m] | wait half life of 65... ideally a booster every 130 days? | 22:51 |
| de-facto | and it seems those are very long lasting | 22:51 |
| LjL-Matrix | elephpant: I hope we find something better because I don't think jabbing eight billion people every six months forever is a feasible proposition. But I think for now that's it... | 22:51 |
| de-facto | they will attack and kill cells that are infected with the virus and in the process of producing it | 22:51 |
| TurboTech | The problem is that most people who get Covid 19 present with low Lymphocytes. | 22:51 |
| elephpant[m] | last i checked, the current covid vaccines are 'leaky' vaccines | 22:52 |
| TurboTech | Aand Low monocytes | 22:52 |
| LjL-Matrix | Half life doesn't mean the other half disappears in the other half of the time :p but still roughly it ends up being like that | 22:52 |
| elephpant[m] | as in like they don't give full protection | 22:52 |
| elephpant[m] | compared to i believe the pox vaccine | 22:52 |
| elephpant[m] | so if we invent a nonleaky vaccine, like small pox, it'd be one and done | 22:53 |
| de-facto | e.g. if a body cell gets infected with a virion and begins to transcribe the viral genome from its RNA their ribosomes will produce the polyproteins, the main protease (that can be inhibited by protease inhibitors like the new Pfizer drug) will cut the polyprotein into functional pieces and a new virion can be formed | 22:53 |
| de-facto | when a cell produces the spike protein for new virions those spike proteins will also appear on that cells surface, because the spike protein is a protein that naturally sits in a membrane (by its structure) | 22:54 |
| LjL-Matrix | elephpant: my opinion is it's mainly for two reasons: 1) they don't match the circulating variant, we need Delta vaccines, ideally before the next thing after Delta happens 2) there's little mucosal protection, which could be given by an intranasal vaccine, and we should pour more money into those | 22:54 |
| elephpant[m] | ahh 1) is like the same problem with flu vaccines | 22:54 |
| elephpant[m] | 2 is good to have in general for needle phobias too | 22:55 |
| de-facto | hence T-cells will see the part they remembered (from vaccination or previous infection) on that cells surface and then alarm the other parts of the immune system and kill that cell | 22:55 |
| de-facto | its much much more complicated in reality, but that is one pathway in a very simplistic view | 22:55 |
| elephpant[m] | last i checked, rich countries aren't supplementing vitamin D enough either | 22:55 |
| de-facto | TurboTech, SARS-CoV-2 contains a super-antigen, something that can activate significant parts of all T-cells without them specifically preventing infections | 22:56 |
| LjL-Matrix | Vitamin D supplementation will probably be a good idea for most people in the winter, but as to covid, causation is not proven, although there's pretty ample correlation | 22:57 |
| de-facto | .title https://www.pnas.org/content/117/41/25254 | 22:57 |
| Brainstorm | de-facto: From www.pnas.org: Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation | PNAS | 22:57 |
| LjL-Matrix | But still it's hard to go wrong with supplementation, the NHS actually recommends it for everyone above a given age during winter months | 22:57 |
| elephpant[m] | According to ClinicalTrials.gov, there are at least 34 ongoing clinical trials including vitamin C, which have completed or are recruiting people, hospitalized and severely ill with COVID‑19 | 22:58 |
| de-facto | i take Vitamin D3, 2000-4000 I.U. (50-100µg) daily since the begin of the pandemic | 22:58 |
| LjL-Matrix | Can't say anything about vitamin C, that's not been on my radar | 22:58 |
| elephpant[m] | I guess vitamin C isn't too promising for non hospitalized | 22:58 |
| elephpant[m] | most supplements are scams basically | 22:59 |
| LjL-Matrix | The Pfizer and Merck pills are by far the most promising things for people who have covid and are at risk of hospitalization | 22:59 |
| elephpant[m] | Multiple studies have reported links between pre-existing vitamin D deficiency and the severity of the disease. Several systematic reviews and meta-analyses of these show that vitamin D deficiency may be associated with a higher probability of becoming infected with COVID-19, and have clearly demonstrated there are significant associations between deficiency and a greater severity of the disease, including relative increases in | 23:00 |
| elephpant[m] | hospitalization and mortality rates of about 80%.[196][197][198] The quality of some of the studies included and whether this demonstrates a causal relationship has been questioned.[199] | 23:00 |
| elephpant[m] | i heard about those magic pills i think | 23:00 |
| LjL-Matrix | I'm not too happy that Pfizer is ending up having a monopoly on saving people from covid... But it's still great this thing exists | 23:01 |
| de-facto | honestly i am very skeptical about the Merck pill | 23:01 |
| de-facto | fatal mutation cascade for the virus, great, but what about fidelity of other information encoded in RNA, e.g. proteins or even human genome? | 23:02 |
| de-facto | idk i am not convinced that its a good idea yet | 23:03 |
| LjL-Matrix | elephpant: the causal relationship gets questioned because the amount of vitamin D one has may be correlated with many other things about one's health. As a fictional example, let's say that exposure to sun drastically reduces the risk of COVID. Then those who have low vitamin D are at higher risk because vit D is lower when exposure to sun is slower... But supplementing it doesn't give you more exposure to sun | 23:03 |
| elephpant[m] | yeah but i'm willing to bet vitamin D helps :p | 23:03 |
| elephpant[m] | reported that treatment with molnupiravir reduced the risk of hospitalization and death from COVID-19 | 23:04 |
| de-facto | about those main-protease inhibitors, that in principle sounds like a much better approach to me at first sight, but since its a new substance we need to know what other pathways are potentially affected by it, they are figuring that out with their trials currently i assume | 23:04 |
| elephpant[m] | woah are the merck and pfizer pills suppose to help those outside of hospitals too? | 23:04 |
| Brainstorm | New from CIDRAP: Fifth COVID-19 surge tests European countries: Lisa Schnirring | News Editor | CIDRAP News Nov 11, 2021 Dutch advisers have suggested a 2-week lockdown that would cancel events and close theaters but allow schools to stay open. → https://www.cidrap.umn.edu/news-perspective/2021/11/fifth-covid-19-surge-tests-european-countries | 23:04 |
| LjL-Matrix | Yes it has some marked reduction, but look at the Pfizer one | 23:05 |
| LjL-Matrix | Yes | 23:05 |
| de-facto | so at least in principle that Pfizer '332 thingy may be promising, at least i am more curious about that one | 23:05 |
| LjL-Matrix | They are meant for people who have covid but are not yet in hospital but are thought to be at risk | 23:05 |
| Brainstorm | Updates for Bahrain: +27 cases (now 277165), +30479 tests (now 7.1 million) since a day ago | 23:05 |
| de-facto | an efficient (significantly reducing disease severity) oral pill (hence to be taken at home and thereby *very* scalable) with safe side effect profile may really have impact, yet it wont be a solution, its just another contribution in regaining a bit more control over case trajectories, but not over infection chains since it only can be given to identified cases and those usually are already removed from infection chains (hopefully...) | 23:08 |
| de-facto | well it may lower the viral load shedding from a carrier under treatment with antiviral onto its environment, hence thereby also lower the infection risk for other people in the same household or hospital personnel | 23:10 |
| elephpant[m] | LjL-Matrix: ahh they gave trump an antibody treatment along these lines | 23:11 |
| LjL-Matrix | %wik Paxlovid | 23:11 |
| Brainstorm | LjL-Matrix, from English Wikipedia: PF-07321332 is an experimental antiviral drug developed by Pfizer which acts as an orally active 3CL protease inhibitor. It is a covalent inhibitor, binding directly to the catalytic cysteine (Cys145) residue of the enzyme. [... want %more?] → https://en.wikipedia.org/wiki/PF-07321332 | 23:11 |
| LjL-Matrix | elephpant: these are different though, they are antivirals | 23:11 |
| elephpant[m] | yeah | 23:11 |
| LjL-Matrix | Brainstorm: hello | 23:11 |
| de-facto | but such people should be competent in use of PPE, at least the hospital personnel and also those that know to be in proximity of a carrier should educate themselves about how to prevent infection in such a high risk environment | 23:11 |
| elephpant[m] | The PF-07321332 wiki page is sparse | 23:11 |
| LjL-Matrix | It only recently got attention | 23:11 |
| elephpant[m] | I am concerned with | 23:11 |
| elephpant[m] | Others were thought to be promising early in the pandemic, such as hydroxychloroquine and lopinavir/ritonavir, but later research found them to be ineffective or even harmful | 23:11 |
| elephpant[m] | like isn't it like 5% of medications make it to phase 4 trials? | 23:11 |
| LjL-Matrix | These ones are more than "promising". Both phase 3 trials were halted earlier because of efficacy | 23:12 |
| LjL-Matrix | That's probably the best reason to halt a trial | 23:12 |
| elephpant[m] | and shout out to the antivaxxers who don't vax but take a horse dewormer instead | 23:12 |
| elephpant[m] | oh they're both in phase 4 trials?! | 23:12 |
| elephpant[m] | "Beximco became the first manufacturer to sell the generic version of molnupiravir pills" | 23:12 |
| elephpant[m] | that means pfizer won't have a monopoly then? | 23:12 |
| LjL-Matrix | elephpant: they're not in phase 4 per se, they're filing to get EUA | 23:12 |
| LjL-Matrix | Molnupiravil is Merck's onr | 23:12 |
| LjL-Matrix | Although I'm not sure how they are allowed to manufacture it as a generic... | 23:12 |
| elephpant[m] | <de-facto> "its much much more complicated..." <- i found this series, to be a useful summary of immune stuff: | 23:13 |
| elephpant[m] | https://yewtu.be/watch?v=lXfEK8G8CUI | 23:13 |
| elephpant[m] | How The Immune System ACTUALLY Works – IMMUNE. | 23:13 |
| elephpant[m] | LjL-Matrix: in bangladesh it said. Different patent laws? | 23:13 |
| LjL-Matrix | elephpant: maybe. But also it says | 23:14 |
| Brainstorm | New from r/WorldNews: worldnews: NSW Police opposed plan to protect Aboriginal communities before fatal COVID-19 outbreaks → https://old.reddit.com/r/worldnews/comments/qrw2g8/nsw_police_opposed_plan_to_protect_aboriginal/ | 23:15 |
| LjL-Matrix | In September 2021, Merck signed a voluntary licensing agreement with the Medicines Patent Pool (MPP) that allows MPP to sublicense molnupiravir and supply the COVID-19 oral medication to 105 low- and middle-income countries.[19] | 23:15 |
| elephpant[m] | <de-facto> "an efficient (significantly..." <- In before rich countries start handing them out to every citizen for them to take like mints daily. Which would actually maybe work huh? | 23:15 |
| elephpant[m] | LjL-Matrix: i'm surprised they agreed to this lol! | 23:16 |
| elephpant[m] | im surprised we haven't updated to mandatory n95 masks | 23:17 |
| de-facto | elephpant[m], yeah kurzgesagt videos are awesome i like those too | 23:22 |
| de-facto | elephpant[m], well its always a decision about risk to benefit ratio with any medication, so taking them daily may not be doable because they probably also will have some side effects that only can be tolerated over short amount of time | 23:24 |
| de-facto | so just taking main-protease inhibitors daily could only be done if they would not bind or affect any other function or molecule in the body, yet there probably are some other pathways that also get affected by its presence | 23:25 |
| de-facto | so that may mean that affecting such pathways may be tolerable for a limited amount of time, but possibly not long (weeks, months?) time, because then resources may be depleted or balanced systems may become unstable etc pp | 23:26 |
| de-facto | we just dont know the impact of that yet, hence we need trials and accumulate statistics about what is affected by the presence of such a molecule and for how long that may be tolerable | 23:27 |
| de-facto | in case of an infection with COVID the benefit of attenuating viral replication may outway the disadvantage or even risk of affecting other pathways, yet that is a limited duration of treatment with such a molecule | 23:28 |
| de-facto | maybe it also could make sense to give it as preemptive measure to people at risk that very recently got a high exposure risk, e.g. give it to all inhabitants of an elderly home as soon as first signs of an outbreak occur there | 23:29 |
| de-facto | but not in absence of the pathogen or any signs of outbreak, because that should be the "normal case" (absence of pathogen) and its desired to spend the most time in that "normal case" | 23:30 |
| Brainstorm | Updates for Netherlands: +16337 cases (now 2.3 million) since 18 hours ago | 23:30 |
| LjL-Matrix | Taking an experimental antiviral daily even if you're not sick? Doesn't sound safe to me | 23:37 |
| elephpant[m] | de-facto: thanks for explaning! I was mostly kidding about taking it daily, | 23:45 |
| elephpant[m] | but eventually (30+ yrs into the future) if we have a safe enough covid pill, maybe that will be daily | 23:46 |
| de-facto | yeah actually its a question about how specific its affinity is | 23:47 |
| de-facto | e.g. if it only binds to the drug target (on the pathogen) or if it also would "fit" on normal functions | 23:48 |
| de-facto | maybe there are trends that could go something like: the more specific a small molecule drug the easier evasion by antigenic drift (but also potentially the fewer side effects from unwanted other binding), yet the broader (more fundamental) a drug target is (in terms of affected systems) the broader its antiviral function hence the fewer the evasion probability | 23:51 |
| de-facto | so very broad antiviral substances may be almost impossible for a pathogen to evade, yet also probably can only be given at lower concentrations because they would also affect other systems to a degree that may not be tolerable at higher doses | 23:52 |
| de-facto | maybe combining several highly specific drug targets (to minimize side effects, hence maximize tolerable concentrations) with collaboration of may lower the risk of evasion, if "only" one drug target is evaded the others still inhibit the function of the same target molecule | 23:53 |
| de-facto | e.g. why not use several protease inhibitors targeting the same function and/or let them bind to highly conserved parts of that main protease so that evading their binding comes at a significant fitness cost for that specific function of the drug target | 23:55 |
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