| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): This sums up the US approach to vaccinations pic.twitter.com/N8TXH4H2Sm → https://twitter.com/EricTopol/status/1460383281501802498 | 00:11 |
|---|---|---|
| Brainstorm | Updates for Colombia: +2321 cases (now 5.0 million), +24 deaths (now 127833), +35337 tests (now 27.4 million) since a day ago | 00:15 |
| Brainstorm | New from The Lancet (Online): [Comment] Improving gastric balloons to treat obesity: The understanding of the causes, implications, and available treatments for obesity is increasing rapidly. This knowledge gain has been partly driven by the increasing proportion of people affected.1 [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02505-8/fulltext | 00:32 |
| Brainstorm | Updates for Faroe Is.: +27 cases (now 2966), +2 deaths (now 10), +4000 tests (now 529000) since a day ago — Netherlands: +19203 cases (now 2.4 million) since 21 hours ago | 00:40 |
| de-facto | .title https://www.ema.europa.eu/en/medicines/human/EPAR/ronapreve | 00:48 |
| Brainstorm | de-facto: From www.ema.europa.eu: Ronapreve | European Medicines Agency | 00:48 |
| de-facto | .title https://en.wikipedia.org/wiki/Casirivimab/imdevimab | 00:50 |
| Brainstorm | de-facto: From en.wikipedia.org: Casirivimab/imdevimab - Wikipedia | 00:50 |
| de-facto | .title https://www.ema.europa.eu/en/medicines/human/EPAR/regkirona | 00:50 |
| Brainstorm | de-facto: From www.ema.europa.eu: Regkirona | European Medicines Agency | 00:50 |
| de-facto | .title https://en.wikipedia.org/wiki/Regdanvimab | 00:51 |
| Brainstorm | de-facto: From en.wikipedia.org: Regdanvimab - Wikipedia | 00:51 |
| Brainstorm | Updates for Bulgaria: +3223 cases (now 658870), +276 deaths (now 26555), +32048 tests (now 6.1 million) since 23 hours ago — Norway: +783 cases (now 229309), +36479 tests (now 8.4 million) since 23 hours ago | 01:05 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Someone said I was pushing people into unnecessary vaccinations just now, which made my day. → https://twitter.com/hjelle_brian/status/1460398663201538050 | 01:14 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): 🤣 twitter.com/CovidB1tch/sta… → https://twitter.com/hjelle_brian/status/1460402452109299716 | 01:25 |
| Trippy72894 | I would still like others to confirm the previous answers to these questions: | 01:26 |
| Trippy72894 | what's the story with long covid for those vaxd and unvaxd? worse or more likely with unvaxd? | 01:28 |
| Trippy72894 | and second: is there any truth to increased cancer among the vaxd? | 01:28 |
| Trippy72894 | Oh, and what's the overall chance of getting long covid for the vaxd? Rare? | 01:28 |
| Trippy72894 | many many thanks to everyone in this remarkable channel. | 01:28 |
| Brainstorm | Updates for Uruguay: +132 cases (now 396677), +1 deaths (now 6102), +7214 tests (now 4.0 million) since a day ago — United Kingdom: +40139 cases (now 9.6 million) since 21 hours ago | 01:30 |
| de-facto | Trippy72894, you are asking questions about long term effects we simply do not know yet since COVID still is new | 01:34 |
| Trippy72894 | okay, how about apparent long covid? | 01:35 |
| Trippy72894 | sure more may emerge, but now, those vaxd who still get delta, what percentage have zero long covid? | 01:35 |
| Trippy72894 | i mean, most, some, rare? | 01:35 |
| Trippy72894 | generally | 01:35 |
| de-facto | as far as i know there are papers that compare the probability of long COVID symptoms (its am umbrella term, so we have to be quite careful with this) from non-vaccinated infections with vaccine breakthrough infections | 01:36 |
| Trippy72894 | ok and what do those papers say? | 01:36 |
| de-facto | if i remember correctly some reported half the risk of long-COVID in vaccinated breakthrough infections compared to non-vaccinated infections | 01:37 |
| de-facto | so i would assume either similar or less long covid | 01:37 |
| Trippy72894 | ok that checks out with what i read too. i ask here because you folks really dig and dig and can help me know better | 01:37 |
| Trippy72894 | ok | 01:37 |
| de-facto | now there also is another effect: the vaccines protect from 1) death 2) severe progressions 3) infection (in that order with decreasing efficacy) | 01:38 |
| Trippy72894 | and from what you read, zero long covid in vaxd? most? | 01:38 |
| Trippy72894 | 1 and 2 understood. | 01:38 |
| Trippy72894 | for me, vax makes sense, overwhelmingly | 01:38 |
| Trippy72894 | and it also seems that for a short while, it reducese transmission | 01:39 |
| Trippy72894 | so, the cancer thing? | 01:39 |
| Trippy72894 | and second, the chances of zero long covid in the vaxd? | 01:40 |
| Trippy72894 | bottom line, in brief? | 01:40 |
| de-facto | so if 3) lowered breakthrough infections (and from that only half probability) 2) less severe progressions if such a breakthrough infection occurs (there may be a correlation that less severe infections also may have less long-COVID symptoms) there surely is a significant *absolute* reduction of long-COVID when comparing a vaccinated cohort with a non-vaccinated cohort under same infection pressure | 01:41 |
| de-facto | unfortunately the risk for long-COVID is not zero in the vaccinated | 01:41 |
| Trippy72894 | cheers | 01:42 |
| de-facto | we will have to see how that may reduce with repeated vaccination doses | 01:42 |
| Trippy72894 | if it's say cut in half... | 01:42 |
| Trippy72894 | then what is the chance of long covid in the unvaxd? | 01:42 |
| Trippy72894 | "repeated" vaxs, understood | 01:42 |
| de-facto | my suspicion would be that it may be lowered with each additional dose because it hopefully would be like a "training" for the immune system to react in a sane (neutralizing) way (with a broad spectrum of antibody affinity) rather than with some weird autoimmune effects or such | 01:43 |
| de-facto | but we will have to see how the statistics will develop | 01:43 |
| Trippy72894 | ahhhhh "....lowered with each additional dose..." okay | 01:44 |
| Trippy72894 | so the cancer thing? bunk? | 01:45 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Ebola: Sorry dude, virus gotcha.HIV: God's will, you're gone.COVID: But you were old, infirm, inadequate. → https://twitter.com/hjelle_brian/status/1460406512283635715 | 01:46 |
| Trippy72894 | i'm trying to encourage a friend in holland to get vax along with her hubby and 3 kids. | 01:47 |
| Trippy72894 | they now plan to move to sweden where it's "free". | 01:47 |
| de-facto | i mean we also see milder or even asymptomatic infections in the vaccinated, so maybe that means their immune system works more efficiently and does not freak out so much | 01:47 |
| Trippy72894 | i'm very disappointed considering how smart she is | 01:47 |
| Trippy72894 | does not freak out so much, understood. that makes sense | 01:48 |
| de-facto | the cancer thing? well if it directly would occur we probably should see it, because even the very rare side effects become visible when a treatment is given to a very large number of people | 01:48 |
| Trippy72894 | that makes sense | 01:49 |
| Trippy72894 | de-facto, you are very helpful. | 01:49 |
| de-facto | and as far as i know it cancer from vaccination is not a known thing, but we can not definitely exclude it if it only would show very late | 01:49 |
| Trippy72894 | the best advice i could give to my friend is: "try to refute your own beliefs rather than looking for info to confirm it." | 01:50 |
| Trippy72894 | any other advice? | 01:50 |
| Trippy72894 | not a known thing, understood. tell that to those Guelph and Idaho doctors | 01:50 |
| LjL-Matrix | First time I hear of this cancer thing at all | 01:51 |
| de-facto | i mean if we would assume for a moment that e.g. the s-protein would prevent DNA repairs or cut telomeres or such, it would happen even more with the exponential explosion of a viral infection where the whole body gets flooded with virions with exactly the same s-protein as in the vaccines | 01:52 |
| Trippy72894 | i think this is them: Idaho doctor Ryan Cole falsely claims.... and | 01:52 |
| LjL-Matrix | Most cancers develop kinda slowly and subtly, and many are only spotted in advanced stages. So I'd be surprised if after just a year of vaccinations we'd already be spotting increased cancer rates, even if it did cause it | 01:52 |
| Trippy72894 | Byram Bridle is the canadian, but i could be wrong | 01:53 |
| de-facto | so i assume that with the vaccination the exposure time is shorter and the cells producing the s-protein probably will get killed by the immune system anyhow, so they may not survive long enough to mutate or such | 01:53 |
| de-facto | i would assume this is a quite unlikely scenario that cancer from vaccination, but surely there are some long term effects from COVID (as long-COVID hints) | 01:54 |
| Trippy72894 | that's all beyond my mental pay grade, but I understand the bottom line of what you are saying | 01:54 |
| Trippy72894 | cheers | 01:54 |
| Trippy72894 | good channel | 01:54 |
| de-facto | how long term we simply do not know yet since we know all this only short time, its barely 2 years old | 01:54 |
| Trippy72894 | good point | 01:54 |
| Trippy72894 | 2 yrs eh | 01:54 |
| Trippy72894 | i can't remember life before covid | 01:54 |
| de-facto | .title https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00460-6/fulltext | 01:55 |
| Brainstorm | de-facto: From www.thelancet.com: The Lancet | The best science for better lives | 01:56 |
| de-facto | "In univariate models adjusted by age, BMI, and sex, there were lower odds of long-duration (≥28 days) symptoms following two vaccine doses for all participants (OR 0·51, 95% CI 0·32–0·82; p=0·0060; appendix p 7). Compared with unvaccinated controls, individuals after their first or second vaccine dose were less likely to have more than five symptoms in the first week of illness or present to hospital, and were more likely to be com | 01:56 |
| de-facto | pletely asymptomatic, especially if they were 60 years or older (figure 3; appendix p 7)." | 01:56 |
| Trippy72894 | thanks! | 01:56 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The neutralizing antibody level from Covid vaccines correlates with clinical outcomes across vaccines and major variantsthelancet.com/journals/lanmi… @LancetMicrobe pic.twitter.com/tg0uNGjocd → https://twitter.com/EricTopol/status/1460408846887751681 | 01:56 |
| de-facto | "We found that the odds of having symptoms for 28 days or more after post-vaccination infection were approximately halved by having two vaccine doses. This result suggests that the risk of long COVID is reduced in individuals who have received double vaccination, when additionally considering the already documented reduced risk of infection overall." | 01:57 |
| Trippy72894 | okay halved, and the odds of some long covid if unvaxd? | 01:58 |
| Trippy72894 | i've read that the majority of those with symptomatic covid get long term issues | 01:58 |
| Trippy72894 | and that "some" with asymptomatic get some long term issues. | 01:59 |
| Trippy72894 | tru(ish)? | 01:59 |
| de-facto | look at their table 2 | 02:00 |
| Trippy72894 | checking.... | 02:00 |
| de-facto | i guess something like 1 in 10 | 02:01 |
| Brainstorm | Updates for Belize: +206 cases (now 29105), +10 deaths (now 544), +2752 tests (now 330391) since 2 days ago — Gabon: +95 cases (now 36787), +2 deaths (now 268), +5026 tests (now 1.4 million) since 2 days ago — Curacao: +9 cases (now 17234), +739 tests (now 321210) since 23 hours ago | 02:01 |
| de-facto | "Symptoms lasting ≥28 days" | 02:01 |
| Trippy72894 | that's a really good table!! | 02:02 |
| Trippy72894 | de-facto, i would bitcoin you a pizza if you would let me | 02:02 |
| de-facto | the study cohort is described in table 1 btw | 02:02 |
| de-facto | haha na thanks, just keep up that spirit | 02:03 |
| Trippy72894 | cheers | 02:03 |
| Trippy72894 | ok i have to go but have a question about that table next time. i will save the ling. many many thanks | 02:05 |
| Trippy72894 | sorry i meant link. i am not into fish conservation. :) | 02:05 |
| Trippy72894 | bye for now | 02:05 |
| Trippy72894 | sorry that was a cod joke, by the way, and not a good one :) | 02:06 |
| joerg | https://i.imgur.com/joK6OHp.png dark graph = protection against severe course; light blue = protection to catch (and spread) infection at all | 02:06 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): So, as suspected, we have a lab assay that will help predict the level and durability of a vaccine, consideration and timing for boosters.Also for people with prior Covid who get an mRNA vaccine👇 pic.twitter.com/BGjEH7xoWS → https://twitter.com/EricTopol/status/1460413471950999558 | 02:07 |
| joerg | you see how vaccination significantly contributes to reducing R_t (spread of virus) until 60 to 120 days after 2nd shot | 02:09 |
| joerg | I'm eager to see those graphs for 3-shot regimen | 02:10 |
| Rudd-O[m] | https://rudd-o.com/archives/how-to-systematically-track-and-coerce-americans-who-refuse-mrna-therapies/index | 02:10 |
| lastshell | is wiese to vaccine all 3rd booster or just eldearly population ? | 02:13 |
| de-facto | .title https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3949410 | 02:13 |
| Brainstorm | de-facto: From papers.ssrn.com: Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study by Peter Nordström, Marcel Ballin, Anna Nordström :: SSRN | 02:13 |
| de-facto | joerg, is that the source of your graph there? | 02:13 |
| de-facto | also for comparison | 02:15 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.10.13.21264966v1 | 02:15 |
| Brainstorm | de-facto: From www.medrxiv.org: Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 | medRxiv | 02:15 |
| joerg | prolly, I also only know what's in that picture which I shot from TV screen | 02:15 |
| de-facto | authors name match | 02:15 |
| de-facto | Nordström et al | 02:15 |
| joerg | :nod: | 02:18 |
| LjL-Matrix | Speaking of graphs, tonight in "if you think Germany's bad"... http://offloop.net/covid19/?default=Germany;Austria&byPopulation=yes&cumulative=no&smooth=yes&legacy=no | 02:18 |
| avu | LjL-Matrix: the mean over the whole country doesn't even do it justice, while overall 7-dy incidence is 890, some areas in upper Austria are close to 2000 | 02:20 |
| LjL-Matrix | Well, I don't know if this is a phenomenon that has a name in statistics or anything, but if you looked at very small countries, some of them might have been lucky/good and not got any COVID cases at all, but I definitely saw either having way higher per-capita case counts than bigger countries | 02:22 |
| joerg | offloop works again? | 02:23 |
| LjL-Matrix | Austria itself is much smaller than Germany, and Germany being the biggest EU country had so far managed lower spikes than most neighbors | 02:23 |
| LjL-Matrix | joerg: only if you set legacy=no | 02:23 |
| LjL-Matrix | aka "Alternative data source" | 02:23 |
| joerg | aaah ok | 02:23 |
| joerg | btw my statistics still work too ;-) | 02:25 |
| joerg | I just wish somebody would sponsor the 15 bucks / month for the server :-/ | 02:25 |
| joerg | http://reisenweber.net/et_al/covid/covid19_statistics.htm | 02:27 |
| joerg | just updating since RKI (arcgis) messed up toady again | 02:31 |
| de-facto | .title https://github.com/orgs/robert-koch-institut/repositories | 02:35 |
| Brainstorm | de-facto: From github.com: Robert Koch-Institut · GitHub | 02:35 |
| Rudd-O[m] | <joerg> "http://reisenweber.net/et_al/..." <- That data should be turned into a Grafana data source. | 02:37 |
| joerg | why? | 02:39 |
| joerg | de-facto: ta!# | 02:43 |
| Rudd-O[m] | <joerg> "why?" <- because it would be easy to zoom in and browse, and slice along different axes | 02:48 |
| joerg | to do this, you may download http://reisenweber.net/et_al/covid/covid19_statistics.ods and http://reisenweber.net/et_al/covid/covid19.csv and do your own | 02:49 |
| joerg | or, additionally download http://reisenweber.net/et_al/covid/s_1.sh and http://reisenweber.net/et_al/covid/run_statistics.sh and run the full data leeching on your own (right now 405MB csv data) | 02:51 |
| joerg | or you use offloop, there you can do all that stuff you mentioned | 02:52 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): Rabies never learned to fly.Ebola never figured out how to pole vault.SARS2 likewise has evolutionary limits. → https://twitter.com/hjelle_brian/status/1460426675842260996 | 03:09 |
| joerg | de-facto: yet another one, also Mordström et al https://i.imgur.com/CfThRn3.png | 03:28 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Two notable data points on booster shot effectiveness (VE) vs symptomatic infections1. Astra Zeneca jumped to 93%, had not reached 80% before w/💉💉twitter.com/EricTopol/stat…2. Pfizer VE in UK & Israel = 94%; matched by 96% RCT for efficacy 3 vs [2 shots + [... want %more?] → https://twitter.com/EricTopol/status/1460432607108165633 | 03:30 |
| Brainstorm | Updates for Canada: +3875 cases (now 1.8 million), +47 deaths (now 29435) since 11 hours ago — Peru: +830 cases (now 2.2 million), +37 deaths (now 200672), +23601 tests (now 19.7 million) since a day ago — United Kingdom: +39889 cases (now 9.6 million) since 20 hours ago — Netherlands: +25 cases (now 2.4 million) since 9 hours ago | 03:41 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): US new cases 7-day average up to 85,000 today with nearly 147,000 added, a 14% increase from a week agonewsnodes.com/us pic.twitter.com/ROXndlVhPx → https://twitter.com/EricTopol/status/1460446048539660294 | 04:23 |
| Brainstorm | New from r/WorldNews: worldnews: No 10 plans booster jab requirement for people to obtain Covid pass | Coronavirus → https://old.reddit.com/r/worldnews/comments/quy3zu/no_10_plans_booster_jab_requirement_for_people_to/ | 04:34 |
| Brainstorm | Updates for Belgium: +27762 cases (now 1.5 million), +82 deaths (now 26403), +221038 tests (now 23.0 million) since 3 days ago — Germany: +34957 cases (now 5.1 million) since 19 hours ago — India: +8865 cases (now 34.5 million), +197 deaths (now 463852) since 23 hours ago | 05:45 |
| Brainstorm | New from r/WorldNews: worldnews: Brazil surpasses the United States in the rate of complete vaccination → https://old.reddit.com/r/worldnews/comments/quzd8i/brazil_surpasses_the_united_states_in_the_rate_of/ | 05:47 |
| Brainstorm | New from The Indian Express: World: CDC issues ‘Level One’ Covid-19 travel health notice for India → https://indianexpress.com/article/world/cdc-issues-level-one-covid-19-travel-health-notice-for-india-7624990/ | 06:29 |
| Brainstorm | Updates for West Flanders, Belgium: +4383 cases (now 141823) since 3 days ago — East Flanders, Belgium: +4159 cases (now 171135) since 3 days ago — Saxony-Anhalt, Germany: +1762 cases (now 125693), +7 deaths (now 3652) since a day ago — Cayman Islands, United Kingdom: +776 cases (now 4203) since 4 days ago | 06:41 |
| Brainstorm | Updates for Kyrgyzstan: +103 cases (now 182528), +3 deaths (now 2710), +5668 tests (now 1.8 million) since 23 hours ago | 07:00 |
| Brainstorm | New from MedicineNet: (news): Federal Court Backs Stay on COVID Vaccine Mandate → http://www.medicinenet.com/script/main/art.asp | 07:11 |
| Brainstorm | Updates for Georgia: +5204 cases (now 791115), +83 deaths (now 11140), +52834 tests (now 11.0 million) since a day ago | 09:04 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | November 16, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/qv2swi/daily_discussion_thread_november_16_2021/ | 09:06 |
| Brainstorm | Updates for Czechia: +11554 cases (now 1.9 million), +95 deaths (now 31636), +105767 tests (now 42.1 million) since a day ago — Taiwan: +2 cases (now 16498), +30011 tests (now 8.0 million) since a day ago | 09:29 |
| imaginary | czechia :/ | 09:30 |
| aruns | Hi, what is meant by PCR test amplification? | 09:52 |
| Brainstorm | Updates for Hungary: +5323 cases (now 966167), +165 deaths (now 32336), +21491 tests (now 7.9 million) since 22 hours ago — Lithuania: +1939 cases (now 446120), +31 deaths (now 6375), +23683 tests (now 5.9 million) since 23 hours ago — Estonia: +867 cases (now 213474), +6611 tests (now 2.3 million) since 23 hours ago [... want %more?] | 10:06 |
| Brainstorm | Updates for Austria: +10363 cases (now 981904), +61 deaths (now 11807), +464540 tests (now 104.2 million) since 19 hours ago — Gambia: +6 cases (now 9986), +1259 tests (now 121854) since 5 days ago — Germany: +34961 cases (now 5.1 million) since 23 hours ago | 10:31 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Boosters not only replenish immunity against transmission but lift it too, new data shows → https://old.reddit.com/r/CoronavirusUK/comments/qv37lr/boosters_not_only_replenish_immunity_against/ | 10:51 |
| Brainstorm | New from StatNews: Opinion: The pandemic didn’t increase suicides. That shouldn’t be a surprise: Pandemic-related changes may have actually reduced stressors of a large portion of the population, particularly those who were already struggling with mental health issues. → https://www.statnews.com/2021/11/16/the-pandemic-didnt-increase-suicides-that-shouldnt-be-a-surprise/ | 11:02 |
| Brainstorm | Updates for Russia: +36818 cases (now 9.1 million), +1240 deaths (now 257837), +356565 vaccines (now 61.5 million) since a day ago — Slovakia: +6421 cases (now 569866), +46 deaths (now 13644), +10070 vaccines (now 2.5 million), +24291 tests (now 4.3 million) since a day ago [... want %more?] | 11:08 |
| aruns | PCR test amplification is where you replicate viral material from the provided sample to the point where it can be detected, right? | 11:19 |
| Brainstorm | Updates for France: +3338 cases (now 7.4 million), +76 deaths (now 119178) since 23 hours ago — United Kingdom: +39842 cases (now 9.6 million) since 18 hours ago | 11:33 |
| Brainstorm | Updates for Latvia: +1077 cases (now 241839), +31 deaths (now 3796), +14409 tests (now 5.2 million) since a day ago — Finland: +937 cases (now 171222), +23683 tests (now 7.7 million) since 23 hours ago — Nepal: +339 cases (now 817672), +4 deaths (now 11482) since 22 hours ago — Brunei: +76 cases (now 14291), +6446 tests (now 566587) since a day ago | 12:04 |
| Brainstorm | New from ProPublica: One Major Reason the U.S. Hasn’t Stopped Syphilis From Killing Babies: by Caroline Chen ] ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. This op-ed [... want %more?] → https://www.propublica.org/article/one-major-reason-the-u-s-hasnt-stopped-syphilis-from-killing-babies#1166465 | 12:06 |
| Brainstorm | New from ECDC: Data on COVID-19 vaccination in the EU/EEA: The downloadable data files contain information on COVID-19 vaccination in the EU/EEA. The data are presented in the Vaccine Tracker and collected through The European Surveillance System (TESSy). → https://www.ecdc.europa.eu/en/publications-data/data-covid-19-vaccination-eu-eea | 12:27 |
| Brainstorm | Updates for Laos: +1306 cases (now 56324), +6 deaths (now 110), +6865 tests (now 719584) since a day ago — Uganda: +37 cases (now 127002), +2 deaths (now 3241), +5427 tests (now 1.9 million) since a day ago | 12:42 |
| Brainstorm | Updates for Indonesia: +347 cases (now 4.3 million), +15 deaths (now 143685), +258012 tests (now 50.7 million) since a day ago — Zambia: +12 cases (now 210008), +4511 tests (now 2.7 million) since 21 hours ago | 13:00 |
| Brainstorm | New from The Indian Express: World: China pet killings spark fear among quarantined covid patients → https://indianexpress.com/article/world/china-pet-killing-quarantine-covid-19-7625894/ | 13:09 |
| de-facto | aruns, correct | 13:10 |
| de-facto | it replicates the DNA (made from the samples RNA), doubling it with each thermocycle. the so called CT (cycle threshold) value indicates how many of those (doubling) thermo cycles are required to reach the detection threshold. hence the lower the required CT value the more RNA was already in the sample from the start | 13:12 |
| de-facto | with the initial A/B strain in early 2020 in China the CT value was ~10 times lower than with current Delta (B1.617.2) variant of concern, hence the RNA load in current samples maybe 2^10 ~ 1024-fold of the initial variant | 13:15 |
| Raf[m] | Just a pcr test | 13:23 |
| de-facto | each PCR pipeline/machine got their own set of parameters, so comparing directly CT values between different setups may not make too much sense, each lab is calibrated for having the optimal set of parameters to maximize the predictive value of their PCR test | 13:24 |
| de-facto | if they do not make mistakes PCR test is insanely accurate (very sensitive, low rate of false negative and very specific, low rate of false positive) | 13:25 |
| de-facto | with the primers (initial pieces of the amplification "puzzle") one could even detect the presence of certain mutations that define a Voc (such as Alpha, Delta etc) | 13:26 |
| de-facto | without the need to make a full sequence of that sample | 13:26 |
| de-facto | afaik they also always use multiple primers on different (conserverd) regions, just to make sure that at least one of them fits (antigenic drift "mutations" may prevent a primer to "puzzle" onto its specific DNA piece) | 13:28 |
| de-facto | it does test for the presence of the pathogen RNA, not if the virions are intact and infectious, so PCR can not distinguish between highly infectious virions and virions that are inactivated because their surface is cluttered with neutralizing antibodies or such | 13:30 |
| Brainstorm | New from The Indian Express: World: Pfizer agrees to let other companies make its Covid-19 pill → https://indianexpress.com/article/world/pfizer-agrees-to-let-other-companies-make-its-covid-pill-7625943/ | 13:31 |
| de-facto | but since the mucus where such samples are taken from (with the cotton swab) constantly clears such things (e.g. constant sink rate of "garbage") the presence of viral RNA there implies a source rate (e.g. recent viral replication) of the RNA in the virions, hence most likely an ongoing viral replication to some degree | 13:32 |
| de-facto | so a positive PCR test is highly indicative for the presence of infectious virions, but to determine the degree of such "intact" infectious virions one would have to take a sample and try to replicate it in cell cultures | 13:34 |
| de-facto | that is a very expensive method (i guess it requires a level S3 biosafety conform lab) that also takes long time | 13:35 |
| de-facto | and since PCR indicates recent viral replication (some recent source rate of RNA) it indicates that most likely some of the virions from a fresh sample are new enough that they still are intact and infectious | 13:37 |
| Brainstorm | Updates for Romania: +4128 cases (now 1.7 million), +397 deaths (now 53661), +55640 tests (now 15.5 million) since a day ago — Qatar: +146 cases (now 241378), +5198 tests (now 2.9 million) since a day ago | 13:38 |
| de-facto | https://en.wikipedia.org/wiki/Polymerase_chain_reaction | 13:38 |
| de-facto | .title | 13:38 |
| Brainstorm | de-facto: From en.wikipedia.org: Polymerase chain reaction - Wikipedia | 13:38 |
| de-facto | btw there also are other methods to amplify samples for a highly sensitive detection of their presence | 13:39 |
| de-facto | .title https://en.wikipedia.org/wiki/Loop-mediated_isothermal_amplification | 13:39 |
| Brainstorm | de-facto: From en.wikipedia.org: Loop-mediated isothermal amplification - Wikipedia | 13:39 |
| de-facto | it would be fantastic if we would have a decentralized network of small well calibrated machines for such tests that would require a minimum of consumables, hence only the sample tubes and the ingredients for their reaction process | 13:42 |
| de-facto | because then we would have a scalable and decentral solution for parallel testing of the population for any pathogen currently in circulation | 13:42 |
| de-facto | building up such capabilities would be a real benefit of this pandemic, yet i do not know of any country that aims for doing that | 13:43 |
| de-facto | just imagine enough capacity to provide a PCR or LAMP test for every citizen two times a week, where would the pathogen hide then? | 13:44 |
| de-facto | and it also could be very easy: for respiratory diseases simply gargling with salty water and spitting into a test tube in the morning before breakfast would suffice for a highly accurate sample | 13:45 |
| de-facto | last year we had such a system at our university, it took 2 minutes in the morning to take the sample and another minute to throw the closed test tube with bar code into a mailbox where the lab collected the samples for each day before 10 in the morning | 13:47 |
| dzho | interesting | 13:59 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): It's sad that neither Pfizer nor Merck antivirals are presently available in US. The Wave is coming and they'd save many lives. → https://twitter.com/hjelle_brian/status/1460595217883492352 | 14:13 |
| Guest882 | anyone here now | 14:28 |
| genera | moo | 14:29 |
| * Rudd-O[m] uploaded an image: (128KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/jTSysONavbqnazcpbYyzvjMY/IMG_20211116_141655_961.jpg > | 14:29 | |
| Guest882 | okay | 14:29 |
| Guest882 | Vietnams cases is growing very soon now | 14:30 |
| Guest882 | it may be the worst wave since it started | 14:31 |
| Guest882 | Now the confirm and death in Vietnam has been far away from South Korea | 14:32 |
| Guest882 | At the beginning of 2021, Vietnam was much less comfirmed than South Korea | 14:34 |
| Brainstorm | New from r/WorldNews: worldnews: Russia’s top brass reports on successfully striking defunct satellite in tests → https://old.reddit.com/r/worldnews/comments/qv7eze/russias_top_brass_reports_on_successfully/ | 14:35 |
| Brainstorm | Updates for Vietnam: +10259 cases (now 1.0 million), +87 deaths (now 23270), +238597 tests (now 64.7 million) since a day ago — Switzerland: +4287 cases (now 923037) since 22 hours ago — Germany: +31549 cases (now 5.1 million) since 22 hours ago — Gibraltar: +73 cases (now 6634), +1927 tests (now 401273) since 23 hours ago | 14:40 |
| Brainstorm | New from r/WorldNews: worldnews: Pfizer Will Allow Its Covid Pill to Be Made and Sold Cheaply in Poor Countries → https://old.reddit.com/r/worldnews/comments/qv7mtt/pfizer_will_allow_its_covid_pill_to_be_made_and/ | 14:45 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Regkirona, regdanvimab, COVID-19 virus infection, Date of authorisation: 12/11/2021, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/regkirona | 15:07 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Biogen R&D chief retiring amid controversy over Alzheimer’s drug; Pfizer strikes deal for generic versions of its Covid pill → https://www.statnews.com/pharmalot/2021/11/16/covid19-pfizer-biogen-alzheimers-opioids/ | 15:28 |
| Brainstorm | Updates for United Kingdom: +39915 cases (now 9.6 million) since 22 hours ago | 15:30 |
| Brainstorm | New from COVID tweets: Punctuated Equilibrium (3x💉) 🇮🇱 🇺🇸🇨🇼🇪🇬 (@GainOfDystopia): New Israeli Study: Everyone needs to get a Covid booster shot regardless of age. jpost.com/health-and-wel… @fitterhappierAJ @ChristosArgyrop → https://twitter.com/GainOfDystopia/status/1460617378912509955 | 15:50 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Irrespective of age, people vaccinated with two shots of the Pfizer coronavirus vaccine in January and February had a 51% increased chance of contracting the virus in July compared to those who were vaccinated in March or AprilGet a third [... want %more?] → https://twitter.com/fitterhappierAJ/status/1460622017993007106 | 16:00 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): One year ago today, the Moderna announcement of Covid vaccine efficacy data—94.5%. Now more than 7,500,000,000 doses of vaccines have been given. pic.twitter.com/mjhOf0u7F6 → https://twitter.com/EricTopol/status/1460625984428789771 | 16:22 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The problem with vaccine waning 4-6 months later was 1st recognized in Israel in July, confirmed by more than 10 reports, and occurs with all vaccines. Protection is fully restored (or even exceeded) by 3rd (booster) shots. pic.twitter.com/vIWvnwgKHE → https://twitter.com/EricTopol/status/1460629386646806534 | 16:33 |
| Brainstorm | Updates for Dominican Rep.: +1002 cases (now 398018), +4 deaths (now 4174), +9680 tests (now 2.3 million) since 21 hours ago — Canada: +4308 cases (now 1.8 million), +48 deaths (now 29436) since 22 hours ago | 16:38 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The >95% vaccine efficacy vs hospitalizations and deaths for mRNA vaccines in the Phase 3 randomized trials also waned. Protection is fully restored to this high level by 3rd (booster) shots. pic.twitter.com/YzsiDMJX7n → https://twitter.com/EricTopol/status/1460631512114630656 | 16:44 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): How long will it last? Nobody knows for sure yet.But let's hope Israel is right again:"By analyzing the antibody levels, researchers have concluded that the third shot could be effective for 9 – 10 months, or even longer."timesofisrael.com/pfizer-booster… → https://twitter.com/EricTopol/status/1460635987894177794 | 16:55 |
| Brainstorm | New from ClinicalTrials.gov: (news): Effectiveness of a Physical Therapy Telerehabilitation Program in Long Post COVID-19 Symptoms in Primary Health Care. → https://clinicaltrials.gov/ct2/show/NCT05121688 | 17:06 |
| Brainstorm | New from ClinicalTrials.gov: (news): COVID-19 Vaccine Biomarker Study in Multiple Sclerosis → https://clinicaltrials.gov/ct2/show/NCT05121662 | 17:28 |
| Brainstorm | Updates for Netherlands: +20198 cases (now 2.4 million), +35 deaths (now 19228) since 23 hours ago — Greece: +8364 cases (now 847188), +85 deaths (now 16923), +662728 tests (now 31.2 million) since 23 hours ago — Chile: +1625 cases (now 1.7 million), +4 deaths (now 38005), +51132 tests (now 24.6 million) since 23 hours ago | 17:40 |
| Brainstorm | New from ClinicalTrials.gov: (news): Extension Study in a Cohort of Adult Patients With COVID-19 Infection → https://clinicaltrials.gov/ct2/show/NCT05121740 | 17:50 |
| Brainstorm | New from ClinicalTrials.gov: (news): Covid-19 Pandemic and Use of Video Laryngoscopy → https://clinicaltrials.gov/ct2/show/NCT05121701 | 18:32 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): We've been in the digital era for years, but just now discovering in medicine that simple text messaging can help substantially reduce Covid deathsacpjournals.org/doi/10.7326/M2…@AnnalsofIM @kit_delgadoMD @PennMedicine @PCORI pic.twitter.com/qvSQpmvpZj → https://twitter.com/EricTopol/status/1460663821815615490 | 18:43 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): "Viral history" and evolutionary principles suggest that animal reservoirs for SARS2 won't breed superlethal or immune-evading SARS2 variants affecting us, but that is only modest compensation for bug finding so many nonhuman animals permissive. [... want %more?] → https://twitter.com/hjelle_brian/status/1460669590329958405 | 19:04 |
| Brainstorm | Updates for Jordan: +3118 cases (now 898682), +24 deaths (now 11279), +40404 tests (now 11.6 million) since 19 hours ago | 19:07 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The worldwide prevalence of #LongCovid, as defined by symptoms beyond 28 days, via review of all available data, is 43% [95% CI 35, 51], with marked heterogeneity among studiesmedrxiv.org/content/10.110… @BhramarBioStat @UMRogelCancer @umichmedicine pic.twitter.com/lszKR4wsjB → https://twitter.com/EricTopol/status/1460671071502278656 | 19:15 |
| kj7rrv | %cases oregon | 19:30 |
| Brainstorm | Updates for United Kingdom: +37464 cases (now 9.7 million), +214 deaths (now 143598) since 21 hours ago — Italy: +7815 cases (now 4.9 million), +74 deaths (now 132893), +684710 tests (now 111.7 million) since a day ago — Maldives: +118 cases (now 90117), +3349 tests (now 1.7 million) since 22 hours ago | 19:30 |
| Brainstorm | kj7rrv: Oregon, United States has had 380091 confirmed cases (9.4% of all people) and 4803 deaths (1.3% of cases) as of 12 hours ago. 471935 tests were done (80.5% positive). +1917 cases, +53 deaths since 3 days ago. See https://offloop.net/covid19/?default=Oregon | 19:30 |
| Brainstorm | kj7rrv: If you know of an official or otherwise good site for data about Oregon, with a reasonably short URL, please %tell LjL about it. | 19:30 |
| kj7rrv | %cases usa | 19:31 |
| Brainstorm | kj7rrv: United States has had 48.1 million confirmed cases (14.6% of all people) and 784779 deaths (1.6% of cases) as of 15 hours ago. 723.4 million tests were done (6.6% positive). 227.1 million were vaccinated (68.9%). +11394 cases, +74 deaths since 22 hours ago. See https://offloop.net/covid19/?default=United%20States | 19:31 |
| Brainstorm | kj7rrv: If you know of an official or otherwise good site for data about United States, with a reasonably short URL, please %tell LjL about it. | 19:31 |
| Brainstorm | New from StatNews: Pfizer to file for emergency authorization for its Covid-19 pill: Pfizer CEO Albert Bourla said at the #STATSummit that the company plans to ask tthe FDA on Tuesday to authorize emergency use of its antiviral pill to combat Covid-19. → https://www.statnews.com/pharmalot/2021/11/16/pfizer-covid19-bourla-pill-paxlovid-fda/ | 19:36 |
| Brainstorm | New from StatNews: Health: Fauci on the next phase of the Covid-19 pandemic and the ‘insanity’ of the threats he faces for pushing masks, vaccines → https://www.statnews.com/2021/11/16/fauci-interview-insanity-covid-stat-summit/ | 19:58 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): COVID-slammed Europe to N America: tag, you're it. pic.twitter.com/YEL0ZbDmXN → https://twitter.com/hjelle_brian/status/1460684339025367045 | 20:08 |
| Brainstorm | Updates for Djibouti: +1 cases (now 13497), +633 tests (now 242215) since a day ago | 20:34 |
| Brainstorm | New from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: November 16, 2021 → http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-november-16-2021 | 20:40 |
| Brainstorm | Updates for Spain: +4091 cases (now 5.1 million), +29 deaths (now 87745) since a day ago | 20:59 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): When otherwise esteemed scientist Peter Duesberg offered to inject himself with HIV to prove it didn't cause AIDS, you can call him a misguided idiot, but you can't call him a hypocritical coward.Where are the antivaxer COVID deniers offering [... want %more?] → https://twitter.com/hjelle_brian/status/1460699500658364418 | 21:11 |
| Brainstorm | New from Reddit (test): nCoV: COVID roundup: only Baja California is not green on the new stoplight map | 15NOV21 → https://old.reddit.com/r/nCoV/comments/qvh244/covid_roundup_only_baja_california_is_not_green/ | 21:22 |
| Brainstorm | Updates for France: +19884 cases (now 7.4 million), +48 deaths (now 119225) since 23 hours ago | 21:37 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Updating my summary Table; the price for Pfizer's pill treatment pack is ~$500 by this US purchase and hopefully indicates competition, further reduction pic.twitter.com/4FHyaSfXcg → https://twitter.com/EricTopol/status/1460711325588353032 | 21:54 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Not your everyday photoSeeing the #SARSCoV2 spike protein post-fusion at nanometer resolution pnas.org/content/118/48…@PNASNews → https://twitter.com/EricTopol/status/1460713926362951681 | 22:04 |
| Brainstorm | New from Politico: Irish tighten pandemic rules as infections surge: Ireland would already be 'in a full-scale lockdown' were it not for its high vaccination rate, Prime Minister Martin tells the nation. → https://www.politico.eu/article/irish-tighten-pandemic-rules-as-infections-surge/ | 22:15 |
| Brainstorm | Updates for Greenland: +31 cases (now 1070), +1075 tests (now 99017) since a day ago — Kuwait: +16 cases (now 413050), +15998 tests (now 5.1 million) since a day ago | 22:45 |
| Brainstorm | New from CIDRAP: Pfizer to allow more nations to make COVID drug, files for EUA with FDA: Lisa Schnirring | News Editor | CIDRAP News Nov 16, 2021 Pfizer has applied for emergency use authorization from the FDA for Paxlovid, its COVID-19 drug. → https://www.cidrap.umn.edu/news-perspective/2021/11/pfizer-allow-more-nations-make-covid-drug-files-eua-fda | 23:08 |
| Brainstorm | Updates for Bahrain: +16 cases (now 277262), +14336 tests (now 7.2 million) since a day ago | 23:10 |
| Brainstorm | New from r/WorldNews: worldnews: COVID-19 spike, deaths after church event 'unfortunate' but part of God's plan, says pastor → https://old.reddit.com/r/worldnews/comments/qvk3v0/covid19_spike_deaths_after_church_event/ | 23:50 |
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