libera/##covid-19/ Monday, 2021-11-22

BrainstormNew from r/WorldNews: worldnews: Rage across Europe as COVID-19 rules trigger riots β†’ https://old.reddit.com/r/worldnews/comments/qz72ji/rage_across_europe_as_covid19_rules_trigger_riots/00:31
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): Even better, inhibitors of the related rhinovirus 3C protease had been developed that were orally bioavailable and capable of reducing disease in humans. This suggested that development of oral inhibitors for SARSCoV2 protease was within physical possibility. β†’ https://twitter.com/michaelzlin/status/146257011608491212801:03
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): But perhaps most irrefutable is that molnupiravir only prevents hospitalization by 50%, when there are other drugs that work far better without any risk whatsoever of viral or human mutation, such as the monoclonal antibodies from Regeneron or Vir, [... want %more?] β†’ https://twitter.com/michaelzlin/status/146257308174300774501:13
LjLde-facto, https://twitter.com/michaelzlin/status/1462573067423600644 (it's what Brainstorm posted above, but i think you'll nod at this particular passage)01:13
BrainstormUpdates for United Kingdom: +39548 cases (now 9.9 million) since 23 hours ago01:32
* de-facto nods03:12
BrainstormUpdates for Netherlands: +20685 cases (now 2.5 million) since 23 hours ago03:37
DreddIt certainly seems like a good idea to work out whether useful mutation rate is increased on the cases where it doesn't work yeah04:09
DreddThis Twitter person works somewhere that has an effective drug with similar action to the Pfizer one side Sep 2020?04:13
DreddWhy the hell has it been taking this long for things to happen?04:13
LjLDredd, that's kind of what some obsessive people like me and de-facto have kept saying :P04:19
LjLbut then hey i don't develop drugs04:20
DreddMaybe we should start our own lab and pharmaceutical company?04:28
DreddI feel like De-Facto Labs would be a good name04:29
DreddOur mission statement could be "Absolutely, Strictly, With No Exceptions"04:29
DreddWhat do you guys think?04:30
LjL:P04:51
BrainstormUpdates for Germany: +26239 cases (now 5.4 million) since 19 hours ago β€” India: +8197 cases (now 34.5 million), +249 deaths (now 465911) since 8 hours ago05:41
joergLjL: was my first thought too. Or actually my second, seems I recall the operation mechanism is by substitution of one of C A G T by some unstable stuff. How's that a good idea for normal cells that also do DNA duplication?06:15
joerg*I* wouldn't dare taking molnupiravir for now06:17
BrainstormUpdates for Lombardy, Italy: +1431 cases (now 916003), +2 deaths (now 34280) since 23 hours ago β€” Shandong, China: +7 cases (now 1011) since a day ago β€” Atacama, Chile: +1 deaths (now 366) since a day ago06:31
joerg>>which is if molnupravir might also be mutagenic to human DNA. That would obviously be a no-go, but Merck reported no mutagenesis in mammals in vivo,Β«  not really reassuring06:31
* joerg glares at http://offloop.net/covid19/?default=Spain;Portugal&byPopulation=yes&cumulative=no&smooth=yes&miscType=Reff&leftTrim=-40&rightTrim=3&legacy=no07:21
joergde-facto: leftTrim=-40 is more convenient (and dynamic too) than leftTrim=66007:26
joerg:-)  thanks again to rjsspam222 for implementing my suggestion there07:28
BrainstormUpdates for Hungary: +27209 cases (now 1.0 million), +392 deaths (now 33172), +127729 tests (now 8.1 million) since 2 days ago10:03
BrainstormUpdates for Germany: +24829 cases (now 5.4 million), +55296 vaccines (now 58.6 million) since 20 hours ago10:40
BrainstormUpdates for Nepal: +367 cases (now 819386), +4 deaths (now 11500), +9921 tests (now 4.6 million) since 23 hours ago β€” France: +38 cases (now 7.5 million) since 15 hours ago12:38
BrainstormUpdates for Germany: +24844 cases (now 5.4 million) since 23 hours ago13:46
BrainstormUpdates for Bangladesh: +264 cases (now 1.6 million), +2 deaths (now 27955), +18614 tests (now 10.7 million) since 22 hours ago13:59
BrainstormUpdates for Switzerland: +14582 cases (now 955800) since 2 days ago14:30
BrainstormUpdates for France: +511 cases (now 7.5 million), +2 deaths (now 119426) since 19 hours ago β€” Canada: +1298 cases (now 1.8 million), +5 deaths (now 29551) since 21 hours ago β€” Papua New Guinea: +30 cases (now 34472), +43 deaths (now 529) since 15 hours ago β€” United Kingdom: +33 cases (now 9.9 million) since 21 hours ago16:41
BrainstormUpdates for Netherlands: +23044 cases (now 2.5 million), +29 deaths (now 19440) since 23 hours ago17:30
LjL-Matrixjoerg: it might not be. The trial didn't find huge side effects, but I'm not sure I've they've waited long enough for cancer :p ironic thing, wanna bet that people who won't take the vaccine because of fear of unknown long term effects will readily take molnupiravir if they do get sick?17:56
LjL-MatrixAnyway, yeah, don't take it considering Pfizer's pill is better :p17:56
BrainstormUpdates for Grenada: +2000 cases (now 7873) since 16 hours ago β€” Italy: +6403 cases (now 4.9 million), +70 deaths (now 133247), +267570 tests (now 114.8 million) since 23 hours ago18:39
DreddGiven the choice of it or nothing20:09
Dredd<LjL-Matrix> "Anyway, yeah, don't take it..." <- I think a high risk person getting covid symptoms should probably take it if they feel shit20:09
LjLDredd, i meant given a choice he might want to pick the Pfizer drug instead. i didn't literally mean "avoid that one", i said it that way because he was already being skeptical. maybe not a good thing to say for other people who read it though.20:10
LjLsometimes i forget one should be extra careful with not sounding like telling what medicines to take :P20:11
LjLactually i think i am careful most of the time, i slipped just a bit20:11
BrainstormUpdates for United Kingdom: +44458 cases (now 9.9 million), +45 deaths (now 144414) since 18 hours ago β€” Spain: +15875 cases (now 5.1 million), +13 deaths (now 87832) since 2 days ago β€” Canada: +1261 cases (now 1.8 million) since 23 hours ago20:12
LjLhttps://twitter.com/hjelle_brian/status/1462570024674025475  https://www.fiercehealthcare.com/tech/boosted-by-microsoft-s-tech-adaptive-biotechnologies-new-diagnostic-test-for-covid-19-gets-fda  T-cell based assay for COVID-19 (so neither PCR nor antibodies), received EUA in the US apparently20:15
LjLit supposedly has pretty high sensitivity and specificity and can detect past infections (perhaps a longer time in the past than antibody assays? not too clear on that)20:15
LjLMicrosoft and "the cloud" are involved :P20:16
LjL"When Adaptive and tech giant Microsoft first teamed up in 2018, they were using cloud computing to β€œdecode” the immune system. The goal of the partnership was to use the biotech company’s immune sequencing capabilities combined with Microsoft's cloud computing to create a universal blood test that reads a person’s immune system to diagnose and treat diseases. "20:16
BrainstormUpdates for France: +5301 cases (now 7.5 million), +97 deaths (now 119521) since 9 hours ago21:39
lastshell I just got my booster shot22:26
lastshellso far no pain in the arm yet22:26
de-factonice congratz22:28
de-factomake sure you drink enough, do not press on the arm (or do not lay on it) and also avoid any activity with elevated pulse rates for the next two weeks22:29
BrainstormUpdates for India: +5064 cases (now 34.5 million) since 16 hours ago β€” Netherlands: +23044 cases (now 2.5 million) since 22 hours ago22:29
lastshellthats funny I mask the nurse and he said is fine todo exercise22:29
lastshellbut I recall is better to avoid it right ?22:29
de-factojust some moderate movements (e.g. going for a walk) probably is a good idea to lower (the already quite low) risk of thrombosis22:29
lastshellok22:30
lastshellwhat about resistance bands I can do it with low resistances ?22:30
de-factoi think moving the arm is good, CDC also recommends "exercise" but i would not lift weights with it as long as it hurts22:30
lastshellok22:30
de-factojust some moderate movements without load and no pressure on the muscle (e.g. do not lay on it)22:31
de-factoid just stick to normal everyday activity or moving the arm on itself (without any load)22:31
lastshellok22:31
de-factoi did just do normal everyday activity, went for a walk (but not run) every day, hence avoided everything with elevated pulse rate or heavy load on the muscle22:33
gryde-facto, what if you lay on it22:52
de-factoit gets pressed and may not stay in the muscle where it should cause the cells to bloom with s-protein in order to only provoke the immune reaction there22:57
de-factoidk it probably all is not really a problem but why not optimize it?22:58
Dredd<LjL> "actually i think i am careful..." <- Don't worry about it πŸ™‚22:59
DreddI don't think there's any evidence it gets squished out πŸ˜‚23:36
DreddI certainly did sleep my arm the night after my jab23:36
DreddIn all cases23:36
DreddEach of them πŸ˜‚23:36
lastshellDreed was the booster ?23:43
de-factoDredd, i just would avoid pressing it, the more remains local in the muscle the less can end up in blood vessels or lymph transport23:44
random-jellyfishit's been about a week since my 3rd dose and I still have a soft swollen lymph node above my collar bone on the side where the vaccine was made23:46
Brainstormrandom-jellyfish: At 2021-11-19 01:03:30 UTC, de-facto told you: happy to see that cases in Romania are going down again, yet i am curious, do you know the main reason why case numbers are dropping in Romania right now?23:46
de-factoyeah i think that is normal, the lymph nodes are where the immune cells are trained23:47
random-jellyfishde-facto cases in Romania have been dropping because restrictions were added for non-vaccinated people and schools were shut for 2 weeks23:47
random-jellyfishit usually takes 2 weeks for restrictions to generate effects around here23:48
de-factoyeah same here too, i think that is the usual timescale23:49
de-factoso its due to reducing contact rates by requiring additional restrictions for non-vaccinated (two thirds?) of the population and closing schools?23:50
random-jellyfishI believe so...also a lot of people got vaccinated but not enough unfortunately...we've reached about 37% fully vaccinated from 30%...still a very small rate23:52
random-jellyfishthe 5th wave will hit us hard, lots of people will die...23:52
random-jellyfishI got my parents vaccinated23:53
random-jellyfishstill struggling to convince my grandfather23:53
de-factoyeah the more vaccinated for the winter the less end up hospitalized23:56
de-factoyet it also seems to make people more careless, hence increase contact rates23:57
de-factotwo effects working against each other23:57
de-factoI am happy that my parents will get the booster on 1st of Dec23:58
de-factoprovided them with good 3M 9330 FFP3 masks if they have to wait there to receive the shots23:59

Generated by irclog2html.py 2.17.0 by Marius Gedminas - find it at https://mg.pov.lt/irclog2html/!