libera/##covid-19/ Saturday, 2021-11-27

BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): And molnupiravir is different from remdesivir. Remdesivir worked by blocking replication entirely, not by inducing mutations. See this article entitled "Molnupiravir: coding for catastrophe". Given the authors' enthusiasm, the irony appears [... want %more?] → https://twitter.com/michaelzlin/status/146436829099064116200:02
de-factomore mutations, yeah thats what we really need :/00:07
de-facto.title https://www.nature.com/articles/s41594-021-00657-800:19
Brainstormde-facto: From www.nature.com: Molnupiravir: coding for catastrophe | Nature Structural & Molecular Biology00:19
BrainstormNew from r/WorldNews: worldnews: US to restrict travel from southern Africa over Omicron Covid variant fears → https://old.reddit.com/r/worldnews/comments/r2zatt/us_to_restrict_travel_from_southern_africa_over/00:31
de-factowe also should provide anything SA needs to contain this, we are lucky they detected it so early00:34
de-factothey should get any resources they ask for00:34
de-factoalso they should ramp up vaccination, the faster the virus is cleared from a host the less time it has to breed on nasty mutations00:37
de-factoOmicron seems to primarily spread in the younger age groups in Joburg so far, hence we dont really know how severe it may become in the elderly00:44
de-factoit could be that it emerged from a immuno-supressed host, e.g. patients received a transplant or cancer patients or HIV immuno-suppressed invididuals00:47
de-factobtw HIV positive people that are well on their therapy (e.g. have a super low or undetectable HIV viral load) will respond very well to infection with SARS-CoV-2, hence those wont be a problem00:50
de-factothe problem rather emerges in individuals that can not clear the SARS-CoV-2 virus due to a weak or suppressed immune system and thereby have a persistent infection00:51
de-factoif such a immuno-suppressed carrier breeding out a mutant is combined with a super-spread event this could be the start of a new variant taking over00:52
de-factosince they noticed an increasing s-gene dropout in the PCR in Gauteng there is such a cluster spread00:54
de-factowe really should support them, its only a few thousand cases or such, it MAY be contained still00:55
de-factodiscriminating SA would be a HUGE mistake, we should support them in every way possible00:56
de-factothe earlier we intervene the higher the chance of success00:56
de-factoonce this is blooming in clusters in communities all around the world it will be near to impossible to contain this00:57
de-factoright now they seem to have more supply than demand for vaccination in SA00:59
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Moderna´s response to omicron (B.1.1.529).businesswire.com/news/home/2021… → https://twitter.com/Marc_Veld/status/146438177681046323300:59
de-facto.title https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-strategy-address-omicron-b11529-sars-cov-201:03
Brainstormde-facto: From investors.modernatx.com: Moderna Announces Strategy to Address Omicron (B.1.1.529) SARS-CoV-2 Variant | Moderna, Inc.01:03
de-facto"Moderna has already tested a higher dose booster of mRNA-1273 (100 µg) in healthy adults. Moderna has completed dosing of 306 participants in a safety and immunogenicity study of this high dose (100 µg) booster. The 100 µg dose of mRNA-1273 has also recently been studied by the National Institutes of Health (NIH) in the U.S. and has generally resulted in the highest neutralizing titers against prior SARS-CoV-2 strains. Moderna is working01:05
de-factoto rapidly test sera from its high dose booster recipients in neutralizing assays to determine if the 100 µg dose provides superior neutralizing protection against Omicron."01:05
de-facto"Moderna is already studying two multi-valent booster candidates in the clinic that were designed to anticipate mutations such as those that have emerged in the Omicron variant. The first candidate (mRNA-1273.211) includes several mutations present in the Omicron variant that were also present in the Beta variant of concern1. The Company has completed dosing in a potentially pivotal safety and immunogenicity study of mRNA-1273.211 at the 50 µg01:05
de-facto (N=300) and 100 µg (N=584) dose levels."01:05
de-facto"A second multi-valent candidate (mRNA-1273.213) includes many of the mutations present in the Omicron variant that were also present in the Beta and Delta variants2. The Company has completed dosing at the 100 µg (N=584) dose level and also plans to explore the 50 µg dose level in approximately 584 participants. Moderna will rapidly expand testing of sera from completed and ongoing multi-valent booster studies to determine if these multi-valen01:06
de-factot candidates are able to provide superior neutralizing protection against Omicron."01:06
de-facto"Moderna will rapidly advance an Omicron-specific booster candidate (mRNA-1273.529). This candidate is part of the Company’s strategy to advance variant-specific candidates for a subset of variants of significant concern. During 2021 this has already included Beta- and Delta-specific boosters. The Company has repeatedly demonstrated the ability to advance new candidates to clinical testing in 60-90 days."01:06
LjLare you pasting the entire press release :P01:06
de-factovery nice they are working already on the update mRNA-1273.52901:06
de-factoi hope they can begin with testing this in a trial soon01:07
de-factothis is how it should be done01:07
LjLyou mean... how Pfizer hasn't been doing?01:07
de-factothey have a trial with delta specific s-protein signature running01:08
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Moderna Announces Strategy to Address Omicron (B.1.1.529) SARS-CoV-2 Variant | Moderna, Inc. ( https://www.zotero.org/groups/covid_links/items/EC54R96V )01:08
de-factoLjL, look at this here https://www.krisp.org.za/manuscripts/25Nov2021_B.1.1.529_Media.pdf01:10
LjLnice find de-facto01:17
de-factoKey questions about B.1.1.529 aka Omicron: 1) Does it have increased reproduction in wide community spread? 2) Does it have immune evasive capabilities (e.g. fitness in vaccinated and/or recovered)? 3) Does it lead to increased disease progression or lead to higher (or new) damage or fatality rates?01:19
de-factoLjL,  was linked from their overview on https://www.krisp.org.za/ngs-sa/ngs-sa_updates_covid-19_analysis_narratives_reports/01:21
de-factoalso we may look at https://ibz-shiny.ethz.ch/covid-19-re-international/ for "South Africa" how their reproduction numbers develop01:22
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: 25Nov2021_B.1.1.529_Media.pdf ( https://www.zotero.org/groups/covid_links/items/EHP769QM )01:23
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: NGS-SA: Network for Genomic Surveillance South Africa ( https://www.zotero.org/groups/covid_links/items/2EZPQR7W )01:23
de-factothey got a really cool map at https://ibz-shiny.ethz.ch/covid-19-re-international/01:23
LjLnice site01:26
de-factoreport about the outbreak from https://www.nicd.ac.za/diseases-a-z-index/disease-index-covid-19/surveillance-reports/weekly-testing-summary/ at https://www.nicd.ac.za/wp-content/uploads/2021/11/COVID-19-Testing-Summary-Week-46-2021.pdf01:27
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: ETH-Zurich's COVID-19 Re ( https://www.zotero.org/groups/covid_links/items/GQ74XRT8 )01:28
de-factoalso on https://www.sacmcepidemicexplorer.co.za/ they provide https://masha-app.shinyapps.io/SACMCEpidemicExplorerPublic/_w_4f9a5e3f/session/a7e318a3df5856e79fd4e6646fedac08/download/report?w=4f9a5e3f01:29
LjLde-facto, that looks truncated01:45
LjLbut i guess it's the latest report01:46
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): The evolution of Omicron is so vast I posit the chronically infected individual who spawned it is still infectedSARS Cov 2 has found a compatible host → https://twitter.com/fitterhappierAJ/status/146439322587206861301:47
LjLstill infected, so it can evolve even more? ;(01:47
de-factoLjL, oh yeah they seem to have some download ticked system in place, probably to prevent deep linking, yeah its the latest report on their main page01:49
busf4ct0ranyone has any "possible good news" about the new variant? I'm tired of this shit, feels like it's neverending and would like some hypothetical good news01:59
minthosthe closest I've got is we don't know how lethal it is02:00
de-factoits summer time in SA, so maybe they can contain it more easily compared to if they had winter time02:00
de-factoalso case numbers are pretty low compared to other scenarios, so maybe its not at bad as we think it is (though i am unsure about that one)02:01
de-factogood news is that we know about this so early, so we may have a chance to contain it with combining efforts02:02
minthosis it early though? it seems it's had time to spread a fair bit already02:03
minthosI guess it could be worse02:03
de-factowell yeah but if they had not discovered it (and reported it bravely) it could just spread incognito and only be detected once it reached other labs worldwide02:04
de-factoits bad news for their local population because many depend on tourism with their income02:04
LjLbusf4ct0r, the good news will be then people will positively ask, no demand, their governments to be proactive, instead of just lazily reacting when it's too late02:05
busf4ct0rI think I'm mostly worried at news that report places with high vaccination rates like Israel having more and more cases, I don't undestand that and I'm scared at things I don't understand, I'm fully vaccinated with AZ since there was no way of getting the Pfizer vaccine for my age group over here... (even though I'm a contractor for Pfizer, lol)02:05
LjLuntil then, we'll just get deeper into this shit02:05
busf4ct0rif the good news is trusting people will do the right thing then we'll have to wait until this gets significantly worse :(02:05
LjLyes, maybe when it significantly gets worse people will get scared enough02:06
LjLand it almost certainly will, so, is that good news? you decide02:06
LjLbusf4ct0r, when you get a booster at least it will probably be with Pfizer or Moderna and not AZ02:06
LjLi don't know about Israel, i've heard that too, but i'm afraid i haven't tried to figure out anything about it02:07
de-factoi think places with high vaccination rate having also increasing cases means that fully vaccinated people are less careful about their contact rates and protection, hence they get a small initial infection in their upper respiratory airways that makes them able to transmit it, but it would not progress to their lower respiratory airways (otherwise they would end up in hospital)02:07
LjLothers here too may have been focusing on Omicron02:07
minthosbusf4ct0r: there are two explanations for that, one is the vaccines only give a fairly small protection agaist infection (the main benefit is reducing severity) and the second is that the virus mutates and the more it mutates the less effective the previous vaccines will be (probably, it's a bit random)02:07
LjLde-facto, but consider Israel has "virtually mandatory" 3rd doses for everyone. if a 3rd dose really gives you 95% immunity again, why would they have rising cases?02:08
de-factothat said, of course this vaccine protection against severe progression also wanes away (fades exponentially) hence the necessity for boosting it up again02:08
LjL%cases israel02:08
BrainstormLjL: Israel has had 1.3 million confirmed cases (14.6% of all people) and 8182 deaths (0.6% of cases) as of 9 hours ago. 20.9 million tests were done (6.4% positive). 6.3 million were vaccinated (68.6%). +236 cases since 20 hours ago. See https://offloop.net/covid19/?default=Israel&legacy=no02:08
LjLwelp, for a country with "virtually mandatory" boosters, they sure have a low vaccination rate...02:09
LjLbut also, uh02:09
LjLtheir cases are not rising? i thought i had also heard about their cases being on the rise, but offloop does not reflect that02:09
de-factominthos, yes both make sense and probably both happen in reality so what we see is a combination of those two effects02:09
LjLare the data bad?02:10
LjLit even shows zero cases for a few days02:10
de-factowell Israel stoppend their third wave with boosting probably https://www.worldometers.info/coronavirus/country/israel/02:11
LjLyes de-facto but apparently busf4ct0r had heard (and i also had heard) that, lately, Israel had a case rise again, and that would be concerning right after a third dose02:11
LjLexcept i don't see that case rise now when i look02:12
LjLso, since i had also heard about that, i'm wondering whether we both heard bollocks, or the data are wrong02:12
minthosall data is bad, some more than others02:12
LjLbecause https://ourworldindata.org/coronavirus/country/israel also shows very few cases, but it also looks like there are artifacts in the recent data02:12
LjLminthos, you know what i mean02:12
LjLi mean is the data *incorrect*02:12
de-factodirectly after vaccination there also is an increased protection against infection of the upper respiratory airways (hence the effect on epidemiological parameters such as reproduction) but that wanes faster than protection against severe progression or death02:12
minthosLjL: that's what I mean02:13
minthosall data is incorrect02:13
LjLokay02:13
busf4ct0rnews being scary just to get clicks and views would make me relax a bit, that I understand, they seeing a small increase of cases and reporting it as something out of proportion02:13
LjLyou still know what i mean02:13
LjLbusf4ct0r, but i'm not seeing even a small increase really02:13
LjLthese data looks strange02:13
de-factobtw israel still got a large amount of non-vaccinated just like other western countries02:14
minthosyou're asking how bad is it, no I don't know that specifically for israel but the general situation is that we have very sparse data about cases and that's true everywhere, the data is always delayed and incomplete02:14
de-factotheir boosting the already vaccinated probably brought down their reproduction number Rt enough (in addition with the containment measures in place) that the outbreak declined (Rt < 1)02:14
LjLminthos, i think i'm quite specifically on about a quite specific thing02:15
LjLare the cases known to be rising in Israel, but somehow my data sources are not showing that due to some flaw02:15
LjLor are my data sources right, and the cases haven't been rising02:15
LjLand by "cases" i mean whatever the government means as cases02:15
LjLbut also i think i'm out of here for the night02:15
LjL%title https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern02:16
BrainstormLjL: From www.who.int: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern02:16
minthosLjL: offloop shows 0 recovered and 0 tests after october so yes obviously something is up with that02:18
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern ( https://www.zotero.org/groups/covid_links/items/ZKQAI9ZH )02:18
LjLbut look at the OWID link too02:18
LjLit has jumps02:18
minthosthat's usually artifacts of testing and reporting02:20
LjLhttps://www.google.com/search?client=firefox-b-d&q=israel+covid+data also shows me an odd jump, but also no increase in cases02:20
LjLbut that's not surprising since their source *is* OWID as well as JHU02:21
LjLand i don't know what https://datadashboard.health.gov.il/COVID-19/general is asking me but presumably i accept...02:21
busf4ct0rdoes this data seem real to you? I've always had a feeling they're extremely under reporting the cases https://offloop.net/covid19/?default=Yucatan&legacy=no02:23
de-factoreporting cases relies on positive tests relies on taking samples02:25
de-factohow well the reported cases represent actual infection dynamics depend on the whole testing strategy (and reporting delay etc)02:25
de-factohence i think it would be a good idea to take a small percentage of testing capacity for randomly sampling a representative selection out of a population in order to test them (without any further indication to do so) just to get a more clear picture about current infection dynamics02:28
de-factoas far as i know UK does have such a program in place02:28
de-factobut most other countries dont have that02:28
de-factoone possible good news about the Omicron variant COULD be if it would combine super high contagion rates with super low disease severity (but we dont know about either), because then it would be like a self replicating vaccine02:43
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): Dr. William Haseltine made the same points earlier than me. See below.I'll just add we now *know* molnupiravir doesn't always kill off SARSCoV2 in people. Heck we know it only prevents hospitalization 30% of the time! Viral mutation is a real [... want %more?] → https://twitter.com/michaelzlin/status/146440888688729292902:43
de-factothough unfortunately i think this would be unlikely, yet we do not know the severity level yet02:43
de-factohence the question about its pathogenicity and reproduction levels02:45
minthosthat would be awesome02:45
minthosomicron the friendly virus keeping us safe from its evil siblings02:45
de-factoit could have all sorts of new properties with that many mutations02:46
de-factoso indeed it would be extremely interesting to get data about its comparative pathogenicity (relative to Delta)02:47
de-facto32 mutations on the spike protein of which 10 are located in the receptor binding domain must mean something02:52
de-factonot even to begin to speak of the rest of the genome02:52
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The mutation map of the 5 Variants of Concernadapted from covariants.org/shared-mutatio…Omicron (B.1.1.529) shares many key mutations of Alpha, Beta, Gamma & Delta, but a lot more added, very likely having been derived from an immunocompromised host with [... want %more?] → https://twitter.com/EricTopol/status/146441060540248064102:53
de-factowhat wast he location of the super antigen?02:55
de-factobetelgeuse, you are dropping in and out a lot02:58
de-factowas the superantigen P(681)RRA(684) on the spike?02:58
de-factohmmmm02:59
de-factothere are several of those03:04
BrainstormNew from Reddit (test): Covid2019: Kids And Superspreaders Are Driving COVID-19 Cases In India, Huge Study Finds : The attack rate — or the risk of transmission from a primary case to someone else — was 80% for passengers sitting next to an infected person on a bus or [... want %more?] → https://old.reddit.com/r/Covid2019/comments/r32oxd/kids_and_superspreaders_are_driving_covid19_cases/03:21
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): And finally, we don't need molnupiravir anyway. It works far worse (~30% vs hospitalization) than drugs that don't cause viral mutagenesis, such as monoclonal antibodies (>70%) or protease inhibitors (89%). → https://twitter.com/michaelzlin/status/146442433176585012003:50
BrainstormNew from The Indian Express: World: Novavax developing vaccine that targets new Covid-19 variant → https://indianexpress.com/article/world/novavax-developing-vaccine-that-targets-new-covid-19-variant-7643849/04:18
BrainstormUpdates for United Kingdom: +49829 cases (now 10.1 million) since 21 hours ago — Netherlands: +71 cases (now 2.6 million) since 10 hours ago04:32
BrainstormNew from r/WorldNews: worldnews: Covid: New variant classed 'of concern' and named Omicron → https://old.reddit.com/r/worldnews/comments/r3451i/covid_new_variant_classed_of_concern_and_named/04:46
BrainstormNew from COVID on Twitter: Mazen🍕🏌️‍♂️🤷‍♂️⛳️ (@JustAMazen): @ScottGottliebMD @dr_kkjetelina “None of this variant stuff changes what you need to do on an individual-level now. Unless, of course, if you weren’t doing anything at all. Get vaccinated. Get boosted. Ventilate spaces. Use [... want %more?] → https://twitter.com/JustAMazen/status/146444838653121331505:23
BrainstormUpdates for Germany: +65580 cases (now 5.7 million) since 19 hours ago — Belgium: +21772 cases (now 1.7 million), +47 deaths (now 26840), +144555 tests (now 24.3 million) since a day ago05:46
de-factoflight passengers from SA to Germany will "have to self-isolate"05:47
de-factoso they are asked kindly to "please stay at home"05:47
de-factoOMG are humans able to learn from mistakes or NOT?05:47
de-factoits just like a deja-vu from two years ago05:51
BrainstormNew from The Indian Express: World: Merck’s Covid-19 pill significantly less effective in new analysis → https://indianexpress.com/article/world/mercks-covid-19-pill-significantly-less-effective-in-new-analysis-7643921/05:52
MeretheSoltvedtOmicron06:09
BrainstormNew from This Week In Virology: TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin: In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, [... want %more?] → https://www.microbe.tv/twiv/twiv-834/06:10
BrainstormUpdates for India: +8318 cases (now 34.6 million), +465 deaths (now 467933), +1141880 tests (now 638.2 million) since a day ago06:11
BrainstormUpdates for Los Lagos, Chile: +320 cases (now 93586), +1 deaths (now 1430) since a day ago — Lombardy, Italy: +2209 cases (now 925051), +7 deaths (now 34330) since a day ago06:42
BrainstormNew from The Indian Express: World: Official: WTO delays key meeting amid Covid variant concerns → https://indianexpress.com/article/world/official-wto-delays-key-meeting-amid-covid-variant-concerns-7644026/06:48
BrainstormNew from The Indian Express: World: Pfizer/BioNTech, Moderna expect data on shot’s protection against new COVID-19 variant soon → https://indianexpress.com/article/world/pfizer-biontech-moderna-vaccine-new-omicron-variant-7644041/07:07
BrainstormNew from r/WorldNews: worldnews: New COVID variant Omicron triggers global alarm, market sell-off → https://old.reddit.com/r/worldnews/comments/r36vha/new_covid_variant_omicron_triggers_global_alarm/07:17
BrainstormUpdates for United Kingdom: +49692 cases (now 10.1 million) since 15 hours ago07:38
BrainstormNew from r/WorldNews: worldnews: Egypt reopens 3,000-year-old Avenue of Sphinxes → https://old.reddit.com/r/worldnews/comments/r37iyk/egypt_reopens_3000yearold_avenue_of_sphinxes/07:54
BrainstormNew from r/WorldNews: worldnews: Canada clamps down on Omicron COVID-19 variant. Experts say it’s likely ‘already here’ → https://old.reddit.com/r/worldnews/comments/r37lvo/canada_clamps_down_on_omicron_covid19_variant/08:04
BrainstormNew from The Indian Express (Health): Life-style: How misinformation has increased the woes of the elderly, especially in the pandemic → https://indianexpress.com/article/lifestyle/life-style/misinformation-elderly-especially-pandemic-technology-health-crisis-digital-information-younger-population-7644096/08:13
joerg » hence i think it would be a good idea to take a small percentage of testing capacity for randomly sampling a representative selection « except Israel has an exceptionally comprehensive database covering all their residents: the health insurance data which is a very special thing in Israel08:26
joergrecommended: <Brainstorm> New from The India... https://indianexpress.com/article/world/pfizer-biontech-moderna-vaccine-new-omicron-variant-7644041/08:30
joerg100 days08:30
joergthen, quite obviously and like always in medicine, nothing is black or white, immunization will still have some effect on Omicron. The question is how much. I bet on 50%<efficiency<90%08:52
BrainstormNew from The Indian Express: World: 61 travellers from South Africa in Netherlands positive for Covid-19, say authorities → https://indianexpress.com/article/world/covid19-variant-south-africa-netherlands-amsterdam-7644180/09:00
BrainstormNew from r/Coronavirus: Daily Discussion Thread | November 27, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/r38r5a/daily_discussion_thread_november_27_2021/09:09
BrainstormNew from The Indian Express: World: Markets tumble as new covid variant Omicron brings travel restrictions, triggers global alarm → https://indianexpress.com/article/world/markets-tumble-as-new-covid-variant-omicron-brings-travel-restrictions-triggers-global-alarm-7644185/09:19
BrainstormUpdates for Lakshadweep, India: +11 cases (now 10394) since 2 days ago09:30
BrainstormNew from r/WorldNews: worldnews: Chinese Spam Network Aims to Discredit U.S. COVID Vaccine and Response, Report Finds → https://old.reddit.com/r/worldnews/comments/r391z5/chinese_spam_network_aims_to_discredit_us_covid/09:38
joerghmmmm https://mobile.twitter.com/davidwdowdy/status/1464409374726701059  » Is it possible that omicron is the next big thing? Yes. But is it probably far more likely that it's not? Also yes. In this situation - where data are early & societal implications are large - scientists have a duty not to oversell. And we are doing exactly that. Shame on us. « sure has a point there09:48
minthosI don't feel it's being oversold09:58
minthosit could be extremely infectious and we don't know much about it so we should be on guard09:58
BrainstormNew from r/WorldNews: worldnews: Hong Kong confirms two cases of virulent new COVID-19 variant, one of which travelled from Canada → https://old.reddit.com/r/worldnews/comments/r39kqm/hong_kong_confirms_two_cases_of_virulent_new/10:15
BrainstormNew from COVID on Twitter: Andrew L. Croxford (@andrew_croxford): Was yesterday the craziest day yet in COVID world? What about the new variant of concern (VOC), omicron (B.1.1.529), in regard to the current vaccine protection and where this may or may not go? 🧵 → https://twitter.com/andrew_croxford/status/146452193225105818110:25
BrainstormUpdates for France: +32 cases (now 7.7 million) since 12 hours ago — Germany: +64754 cases (now 5.7 million) since 20 hours ago10:39
BrainstormNew from r/WorldNews: worldnews: Merck's COVID-19 pill significantly less effective in new analysis - Merck & Co (MRK.N) said on Friday updated data from its study of its experimental COVID-19 pill showed the drug was significantly less effective in cutting hospitalizations [... want %more?] → https://old.reddit.com/r/worldnews/comments/r39y6d/mercks_covid19_pill_significantly_less_effective/10:44
joergmolnupilamivir a bummer? Who might have guessed. The operation principles were highly questionable in my book anyway10:52
BrainstormNew from r/WorldNews: worldnews: 61 arrivals from South Africa test positive for COVID-19 → https://old.reddit.com/r/worldnews/comments/r3amkn/61_arrivals_from_south_africa_test_positive_for/11:40
BrainstormUpdates for Nepal: +197 cases (now 820724), +3 deaths (now 11521), +4907 tests (now 4.6 million) since 23 hours ago12:00
BrainstormNew from COVID on Twitter: BNO Newsroom (@BNODesk): NEW: Czech Republic reports first suspected case of new coronavirus variant in returnee from Egypt bnonews.com/index.php/2021… → https://twitter.com/BNODesk/status/146454839359060378112:09
BrainstormNew from r/WorldNews: worldnews: Travel doors slam shut as new Covid variant triggers alarm, stranding hundreds of passengers → https://old.reddit.com/r/worldnews/comments/r3bamw/travel_doors_slam_shut_as_new_covid_variant/12:18
joergEssen Minister Klose:  >>omicron most likely already in Germany, traveler from SA found highly probably to carry it<< [TV Tagesschau]12:19
BrainstormNew from COVID on Twitter: Florian Krammer (@florian_krammer): 5) Adapted vaccines need to be tested (this has started already) etc. Also, we should not forget that non-neutralizing antibody epitopes and T-cell epitopes are likely largely intact. And even if a variant vaccine becomes necessary, we would not [... want %more?] → https://twitter.com/florian_krammer/status/146455533241654886712:27
BrainstormUpdates for United Kingdom: +49831 cases (now 10.1 million) since 20 hours ago12:37
sdfgsdfgomicron is already spread in all countries12:46
sdfgsdfgaustralia just found out that it also has it12:47
sdfgsdfgif we have it, I bet my ass it's already in U.S12:52
sdfgsdfgand if it's in U.S, we can all bet our asses it's here for christmas :P12:53
sdfgsdfgit's so exciting12:54
sdfgsdfgsaw this news about omicron being 5 times more transmissive ?12:54
sdfgsdfgthat's how it looked in that initial chart from SA12:55
BrainstormNew from COVID on Twitter: Imperial College (@imperialcollege): What is the new #Omicron variant, how is it different, and how concerned should we be? Our researchers discuss the new #COVID19 variant 👇🏾 ow.ly/70Oh50GXysq → https://twitter.com/imperialcollege/status/146456144722943590412:56
sdfgsdfgwow, think of 5 times more transmissive than DELTA that's almost funny12:57
minthosit's not confirmed how quickly it spreads but yes potentially very infectious12:59
sdfgsdfgit partially is13:03
sdfgsdfgThere is still vast uncertainty about the transmissibility with respect to the Delta variant, with a possible 100% increase (2x)[19][20] to 500% increase (6x)13:04
sdfgsdfghttps://www.newsweek.com/new-covid-variant-possibly-500-percent-more-infectious-delta-165359613:04
BrainstormNew from Gazzetta Ufficiale italiana: MINISTERO DELLA SALUTE - ORDINANZA 26 novembre 2021: Ulteriori misure  urgenti  in  materia  di  contenimento  e  gestionedell'emergenza   epidemiologica    da    COVID-19    nella    RegioneFriuli-Venezia Giulia. (21A07066) → http://www.gazzettaufficiale.it/eli/id/2021/11/27/21A07066/SG13:15
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Hey guys. A lot of T cell hopium being irresponsibly passed aroundI'm not cosigning that. If a mild case of Covid is giving lung diffusion issues, and given there is no published t cell correlate of protection, I think it's [... want %more?] → https://twitter.com/fitterhappierAJ/status/146457472959606784113:43
BrainstormNew from The Indian Express: World: Top UK scientist says new COVID-19 variant Omicron ‘not a disaster’, vaccination likely to protect → https://indianexpress.com/article/world/top-uk-scientist-says-new-covid-19-variant-omicron-not-a-disaster-vaccination-likely-to-protect-7644687/13:53
joerg50%<effdiciency<90%, no?14:01
joergdefine: protect14:01
joergdefine: disaster14:06
BrainstormUpdates for Bangladesh: +155 cases (now 1.6 million), +2 deaths (now 27975), +13462 tests (now 10.8 million) since 22 hours ago14:10
joergyou'd think, when your ICUs are already at limit, you're almost out of applicable NPI measures not applied yet, and you maybe were lucky to stomp down your R_t to, say, 0.9, then a 50% more transmissive that kicks your R_t to 1.4 is exactly what spells disaster14:16
BrainstormNew from r/WorldNews: worldnews: Covid: Dozens test positive on SA-Netherlands flights → https://old.reddit.com/r/worldnews/comments/r3d87q/covid_dozens_test_positive_on_sanetherlands/14:21
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): I'd just like my children to grow up in a world where we use vaccines and medicines effectively, and where they don't have to worry about the possibility of hypermutated viruses generated from the irresponsible use of mutagenizing drugs. → https://twitter.com/michaelzlin/status/146458784499598542914:40
BrainstormUpdates for Germany: +66259 cases (now 5.7 million) since 22 hours ago14:41
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): This is my opinion on classrooms given the coming Omicron surge for which there are new vaccines in the pipeline pic.twitter.com/gkaQoZcSfT → https://twitter.com/fitterhappierAJ/status/146459424724033127215:09
BrainstormNew from BBC Health: Two cases of new variant of Covid-19 detected in UK: Two people in the UK have been found to be infected with the new Covid variant, Omicron, the health secretary says. → https://www.bbc.co.uk/news/uk-5944538815:18
lastshellUS will ban travel next monday: South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique and Malawi. https://www.cnn.com/2021/11/26/politics/travel-restrictions-south-africa/index.html15:19
BrainstormNew from The Indian Express: World: Omicron Covid variant: Suspected cases found in Germany and Czech Republic—Key developments → https://indianexpress.com/article/world/new-covid-variant-omicron-key-developments-7644592/15:37
BrainstormUpdates for United Kingdom: +49864 cases (now 10.1 million) since 23 hours ago15:37
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): You cannot wait for a peer reviewed piece of data to come out or preprint to recommend masksI gave the most recent piece of information possible. 65% hospitalized are unvaccinatedYou are using lack of precise data to FUD, whereas I [... want %more?] → https://twitter.com/fitterhappierAJ/status/146460549655234969815:47
de-facto.title v15:52
Brainstormde-facto, the command line provided is invalid15:52
de-facto.title https://www.bbc.com/news/uk-5944538815:52
de-facto%title https://www.bbc.com/news/uk-5944538815:52
Brainstormde-facto: From www.bbc.com: Two cases of new variant of Covid detected in UK - BBC News15:52
de-facto"wo people in the UK have been found to be infected with the new Covid variant, Omicron, the health secretary has said."15:53
de-facto"Sajid Javid said the UK Health Security Agency had detected cases in Chelmsford, Essex, and in Nottingham."15:53
de-facto"He said the cases were linked and the two people were self-isolating alongside their households while more tests and contact tracing take place."15:53
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): This is the problem. While we are dealing with anti-vaxxers and discussing boosers: many have no access to vaccines they desperately want and need! COVID-19 is not over as long as new variants can develop unopposed. Vaccinating the world is critical!twitter.com/MoetiTshidi/st… → https://twitter.com/Marc_Veld/status/146460625495801037315:56
Arsaneritself-isolating is not nearly enough15:57
BrainstormNew from NPR: At least 2 people in the U.K. have the omicron variant, health secretary says: The cases involve travel to southern Africa, where the latest COVID variant of concern was first identified, the British health secretary said. No cases have been [... want %more?] → https://www.npr.org/sections/coronavirus-live-updates/2021/11/27/1059501446/covid-coronavirus-omicron-variant16:06
de-factointercontinental tourists should not be allowed any contact to destination population (not even indirectly), they must be escorted immediately into offsite quarantine facilities and monitored for infections (as it already is established routine for importing animals, why would the same reasoning not exactly also apply to humans)16:07
Arsaneritescorted by who?16:07
de-factomilitary for example16:07
Arsaneritbut military are also destination population?16:08
de-factoyeah but they may have biowarfare equipment16:08
Arsaneritafrica, asia, and europe share land borders16:09
de-factothen those should be closed too16:09
Arsaneritsooner or later it'd spread egypt - israel - lebanon - syria - turkey - EU16:09
de-factoyet as observed now, the main travel routes are via airplanes16:09
Arsanerityou can close land borders but you can't close them hermetically (nor sea borders, see boat refugees)16:10
Arsanerityour proposal would slow down the spread of the virus16:10
de-factoyes hence we may prepare for impact16:10
Arsaneritbut if I understand correctly you want to implement this at all times independent of pandemic16:11
Arsanerithow long sohuld the quarantine be for?16:11
de-factoas its done right now, kindly asking tourists to please be friendly enough to self-isolate in their own households (sic!!!) its going to be imported in a matter of days16:11
de-factoat least 2 weeks16:12
de-factointercontinental tourism is simply completely insane, it must stop and be banned forever16:12
ArsaneritI agree that self-isolating is a joke16:12
minthosmove to madagascar, lobby the government to close the ports :p16:12
spybertde-facto: It kind of looks that way :-(16:13
Arsaneritbut I don't think society will accept to stop all intercontinental tourism to stop completely forever16:13
de-factowell then this will continue forever, more severe and evasive mutants spreading over the globe again and again16:14
ArsaneritI seem to recall Japan was quite strict on quarantine for journalists and sportspeople attending the Olympic Games16:14
spybertI wonder how well South Africa has been keeping track of COVID cases and deaths?16:16
de-factoif a single latent infection anywhere on the globe can reset the pandemic annually we have ensured any vaccination program simply can not possibly outcompete the super rapid mutant spread by low latency intercontinental tourism16:16
de-factoits sad for SA because they do depend economically on tourism, yet were brave enough to report this scary mutant early16:17
minthoswe will get better at dealing with it, it just takes a while16:17
de-factothey should get financial support from the international community for doing us this huge favor of reporting this early16:17
Arsaneritspybert: probably better than Malawi or Congo.16:18
de-factoyet it FUCKING seems that governments are wasting the time advantage they received as gift AGAIN by not isolating imports properly16:18
Arsaneritde-facto: why would you expect them to act any differently now than they did with delta or alpha?16:18
de-factoWHO AGAIN advises against travel bans etc16:18
de-factoi am so fucking mad, why cant humans observe and learn from their mistakes?!16:19
spybertde-facto: If I believe their numbers, SA has one third of the cases the US has, percentage wise.16:19
ArsaneritWe've seen this before.  Only difference is that now many people in wealthy countries are vaccinated, which makes them less likely to be get seriously ill, and that the pandemic has been going on for a while.  Probably there is less, not more, public support for severe travel restrictions.16:19
de-factovaccinated with the s-protein Wuhan-Hu-1 that was seen almost 2 years ago16:20
ArsaneritYes, it's not good enough.16:20
ArsaneritBut hopefully even with omicron it's still better than nothing.16:20
de-factoOmicron got 30+ mutations on that s-protein, 10 of which are in the receptor binding domain alone16:20
de-factowe simply do not know that yet16:21
ArsaneritIndeed we don't.16:21
ArsaneritBut it probably contributes to the probable decrease in support for the type of measures you propose.16:21
de-factoall we know is that this potentially may be very bad, and we should avoid importing and spreading this at any price16:21
de-factoyet mistakes are repeated over and over again16:22
ArsaneritYes, they are.16:22
ArsaneritWhich makes it entirely unsurprising.16:22
lastshellno US cases, but NY https://www.foxnews.com/us/new-york-gov-kathy-hochul-state-of-emergency-omicron-variant.amp16:22
ArsaneritWhen it happened with delta I was still annoyed, but with omicron now I expect nothing else than more of the same.16:22
lastshellwe are starting to freaking out\16:23
ArsaneritModern human civilisation is not capable of dealing with a pandemic of this type.16:23
lastshellwe are in diappers pandemic response16:23
de-factoit may be the first VoC that really could be a lot nastier, we simply dont know, but at least some of these mutations most likely will mean some significant change in properties16:23
de-factoArsanerit, the sad thing is technically we are more than capable of dealing with such a pathogen, yet human mindset simply is WAY behind technological development16:24
Arsaneritde-facto: Technically, yes.  Technically we are also easily capable of preventing anthropogenic climate change, biodiversity loss, or other environmental catastrophes.16:25
ArsaneritBut politically and sociologically we are not capable.16:26
de-factoexactly that16:26
de-factosad but true16:26
ArsaneritA global hard lockdown of four weeks might kill off the virus forever.  This will not happen.16:26
lastshellI wish all goverments will do that ^16:27
ArsaneritThey won't, and even if they tried, many wouldn't be able to enforce it.16:27
ArsaneritPossibly people in rural Malawi who are struggling to find food, or people in rural Central African Republic hoping to survive the civil war, may not even have heard of the coronavirus.16:28
DreddOmicron is in the UK now ☹️16:28
ArsaneritWe are also technically entirely capable of not waging war.16:28
ArsaneritWar is a lose-lose situation, but humans keep doing it.16:28
ArsaneritSo indeed, that humanity is incapable of collectively taking the optimal decision for all is sad, but it's not news.16:29
de-factoDredd, but they were kindly asked to please be friendly enough to self-isolate inside their households16:29
de-factowe know that this works well, dont we?16:29
lastshellDredd that is pretty bad, winter will be ard16:29
lastshell*hard16:29
ArsaneritOmicron is probably all over Europe already, given the level of mobility and the latency before such variants are proven.16:29
minthoscovid's coming home for christmas16:30
Arsaneritminthos: where is home?16:30
minthoseverywhere16:30
lastshellnot fair16:31
lastshellI have family comming from xmas16:31
lastshellIm vaxxed and booster do I need to ventilated the house and wear mask ?16:32
de-factoyes16:33
de-factoLooking at Beta CoV-VoC for comparing travel preferences https://cov-lineages.org/global_report_B.1.351.html16:33
de-facto"The number of ticketed origin-to-destination journeys from South African airports to destinations outside of South Africa during October 2020."16:33
de-factoTraveling from SA to destination in descending order: Ethiopia, United Arab Emirates, United Kingdom, Zimbabwe, Zambia, USA, Kenya, Germany Mozambique, China, Netherlands, Philippines, France, Turkey, Qatar, Pakistan, Tanzania, Canada, Belgium, Egypt, Namibia, Israel, Botswana, Malawi, Switzerland, Italy, India, Portugal, Ireland, Saudi Arabia, Malaysia16:33
de-factolastshell, organize tests for everyone, test everyday during the meeting16:34
lastshellwhat16:34
de-factothats how i do it when i visit my parents16:34
lastshelleven vaxxinated ?16:34
BrainstormNew from r/WorldNews: worldnews: Fears of Omicron loom in Karnataka, India after two South Africans test positive for COVID-19 → https://old.reddit.com/r/worldnews/comments/r3fmnt/fears_of_omicron_loom_in_karnataka_india_after/16:35
de-factoyes of course, vaccination does lower the risk but not prevent infection or transmission16:35
lastshelldamn is insane this times16:35
lastshellI have air purifiers as well16:35
de-factoonly during peak of immunity it will significantly lower the risk of upper respiratory tract infections (hence also spreading)16:36
de-factothats good, just dont drop care because of vaccination16:36
de-factothink about vaccination as a very effective measure to prevent severe progressions16:36
lastshellde-facto we have family with AZ vaxxed that is ok ?16:37
lastshellothers Pfizer16:37
de-factoat least for the currently circulating variants, with Omicron we probably will see soon how it will behave16:37
DreddI'm really going Omicron doesn't turn out to be more servere but just more contagious16:37
de-factoit depends how long ago, it better than nothing but if its long time ago there may be no good protection anymore from it16:38
Dreddde-facto @de-facto:libera.chat: should get good days from the UK soon once we let our dominate16:38
DreddGive us a week or two16:38
Dredds/days/data/16:38
Dredds/days/data/, s/our/it/16:39
de-factowhy do we have to repeat it again and again, its so fucking stupid16:40
lastshellHow many cases are right now detect for omicron Dredd ?16:40
de-factotwo16:40
de-facto%title https://www.bbc.com/news/uk-5944538816:40
Brainstormde-facto: From www.bbc.com: Two cases of new variant of Covid detected in UK - BBC News16:40
de-factoif we are lucky and they switch to proper isolating them in quarantine it may only be those imported ones16:42
de-factobut if they do not isolate them properly (they most likely are not) then it soon may transition to community spread16:42
de-factothat is a big middle finger to the opportunity given to authorities by being informed so early about this VoC by the brave experts of SA that reported this despite it meaning harm to their tourism based economy16:43
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): An accelerated path to an Omicron specific vaccine in less than 3 months ft.com/content/a7aa4b… by @hannahkuchler pic.twitter.com/NPP5jEkkWb → https://twitter.com/EricTopol/status/146462038160024781516:44
de-factoa whole country suffering severe economic impact and its asking too much that those damn tourists are escorted into proper off-site quarantine?16:44
de-factowhy are are tourists more important than having schools open, having stores open and having hospital capacity available for everyone that needs this?16:45
de-factothis absolutely makes no sense to me at all16:46
minthosmisaligned incentives among those who make decisions16:46
de-factolets keep our tourists entertained properly, shall we? this is number one national priority, we go over dead bodies to ensure the tourists are happy16:47
lastshellde-facto humans are stupid, I'm seriously think animals are more sutable to survive pandemic than humans16:47
de-factothis is completely insane16:47
* de-facto needs to go for a walk in the cold to calm down16:48
Arsaneritgerman schools have been trying to buy air filters for some years now, but german (and EU) bureaucracy doesn't cope16:48
Arsaneritif they buy many at once then they must write a EU-wide invitation to tender, which has to be open for a certain amount of time16:49
Arsaneritin my Landkreis they then found a mistake in their ITT so they had to do it all over again16:49
rpifandid yall hear16:50
rpifanomicron is now i the uk16:50
rpifanim sure its now in germany16:50
Arsaneritit's already reported in Germany (Hessen)16:50
lastshellit has to be rpifn sadly16:50
minthosand netherlands, and belgium16:50
Arsaneritsomeone who flew from South Africa16:51
Arsaneritthey flew in one week ago16:51
Arsaneritwhich shows that all those quarantine measurements may be too late anyway16:51
de-factokeep in mind that there is a huge difference between cases that are linked to traveling (they COULD be isolated) and community transmission (where the source of infection is unknown, hence can not be isolated)16:51
Arsaneritthere is no political or societal support for a zero covid strategy16:53
rpifanoh really in hessen?16:53
rpifani mean honestly the fact that we havent lockdowned yet is really annoying16:53
minthosthose 60+ on the plane have almost certainly infected at least one of the hundreds who shared planes with them16:53
rpifanyeaa16:53
rpifanalso the trains16:53
BrainstormNew from Reddit (test): nCoV: Coronavirus in Russia: The Latest News | Nov. 27 | 27NOV21 → https://old.reddit.com/r/nCoV/comments/r3g706/coronavirus_in_russia_the_latest_news_nov_27/16:53
rpifanand airport16:53
Arsaneritrpifan: https://www.hessenschau.de/gesellschaft/ueber-frankfurter-flughafen-eingereist-erster-verdachtsfall-der-corona-mutation-omicron-in-deutschland,omicron-hessen-100.html   not fully confirmed yet16:54
rpifanscheisse16:55
* Arsanerit lives near Frankfurt Flughafen16:55
Arsanerit"An Hessen geht kein Weg vorbei" and no virus variant either16:56
minthosI wonder if anyone has compiled a comparison of the positivity rates of passengers arriving from a country by plane with positivity rates in that country16:56
minthos(the source country, that is)16:56
Arsaneritminthos: among the million papers published on the pandemic, it is statistically likely that someone has done so16:57
ArsaneritBioNTech says "an updated vaccine can be shipped in 100 days if necessary", but how can we get faster approval procedures for vaccine updates?16:57
rpifanhttps://www.youtube.com/watch?v=52f5VmAadyE16:58
rpifancrazy lol16:58
Arsanerit"the European Centre for Disease Prevention and Control (ECDC) reported modeling indicating that strict travel restrictions would delay the variant's impact on European countries by two weeks, possibly allowing countries to prepare for it"16:59
ArsaneritSo yes, travel restrictions are suitable, but to think they can stop omicron from entering would probabyl be naive imho.17:00
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Kids need N95 as well. Updated. pic.twitter.com/AqRpVXKjBW → https://twitter.com/fitterhappierAJ/status/146462441790084301617:03
lastshellhttps://scitechdaily.com/virus-mimicking-antibodies-may-explain-long-haul-covid-19-rare-vaccine-side-effects/17:11
lastshellVirus Mimicking Antibodies May Explain Long Haul COVID-19, Rare Vaccine Side Effects  ^17:11
BrainstormNew from COVID on Twitter: Alberto Román 👟👟🥊 (@alberto_roman83): 👇#Omicron #OmicronIsAirborne twitter.com/fitterhappierA… pic.twitter.com/mCKB9qqcQL → https://twitter.com/alberto_roman83/status/146462732585374106417:12
de-facto.tr <de Wir werden allen ein Quarantäneangebot gemacht haben.17:26
Brainstormde-facto, German to English: We will have made a quarantine offer to everyone. (MyMemory, Google)17:26
de-factoscnr17:26
joergall this turmoil about travel by airplane or at all, again :-/ a) Omicron IS ALREADY spread across *all the world*, no way to make any reasonable impact from unrealistic global lockdown  b) you wouldn't want to live in a world that resulted from this, or if you actually do, you're already free to move to a remote spot somewhere in Siberia or Canada where next human lives a 200km away. There you may pretend it's 1500 again, no electricity, no medicine, no17:28
joergtechnics...17:28
de-factoits not ALREADY spread across the globe, it us currently in the process of doing so, those are travel arrivals that are not properly isolated17:29
de-factohence RIGHT FUCKING NOW we transition from a condition that potentially could be contained to wide spread community transmission17:29
joergdream on, this is the tip of the iceberg17:29
de-factoexactly because of that attitude "its too late, we cant do anything, its over out heads, keep tourists happy" we are going to have widespread community transmission of Omicron17:30
de-factoa self fulfilling prophecy17:31
de-factoi hope this will lead to global ban of airtraveling industry and end intercontinental tourism forever17:32
joergfor each detected Omicron case there are 50 or 1000 that went unnoticed during last 2 weeks already, or last 2 months. The detected cases only half of them even came from SA. Others came from Aegypt, Turkey, whatever17:32
de-factodid they? or did they had intermediate stops there?17:33
joergno17:33
joergthey came from there17:33
de-factoits a difference to say "its in Hongkong" from "a tourist from SA was isolated in HK"17:33
joergorly?17:34
de-factodepending on quarantine stringency of course17:34
de-factowhatever17:34
joergI'm out once more. I can't cope with this insanity. Not even the chinese m,anaged to build a wall to keep "those others" out17:35
de-factowhy are we evacuating from the epicenter of a mutant AGAIN17:35
de-facto.title https://www.reuters.com/world/europe/passengers-south-africa-face-wait-covid-19-testing-amsterdam-2021-11-26/17:36
Brainstormde-facto: From www.reuters.com: 61 travellers from South Africa in Netherlands positive for COVID-19 -authorities | Reuters17:36
de-factoWHY ON EARTH ARE THOSE LET INTO EUROPE?!17:37
joergMAYBE BECAUSE YOU CANT ROLL BACK TIME?17:37
de-factowe are importing this right fucking now AFTER the fact that the VoC was identified17:38
joergsorry...17:38
de-factoevacuating people from the epicenter of an outbreak us an GIGANTIC mistake that is repeated over and over again17:41
de-facto"oh lets quickly bring our people out of there before traveling is banned"17:41
de-factothose need to be isolated into quarantine and THEN tested17:41
de-factojesus christ.17:41
joergstop all airplanes, forever! Masks kill children! close all borders, worldwide, now! vaccines contain chips! mankind is doomed, brains stop working. ON BOTH SIDES :-O17:43
ArsaneritMaybe if chips (fries) contained vaccines we can reach 100% vaccination rate.17:44
de-factoif brains kept working we would not import this right now17:44
ArsaneritWhat % of positive PCR tests are sequenced for variants in the various European countries?  And what % of positive PCR tests of people who arrived from abroad?17:45
ArsaneritI've been told from a non-reliable source the answer is 40%/100% in Sweden to those two questions, but I have no idea about others.17:45
de-factothis is what isolation of a potential new pandemic looks like https://www.reuters.com/resizer/o5GQfjQwrhoV-D48ZZjwhISa_J8=/960x0/filters:quality(80)/cloudfront-us-east-2.images.arcpublishing.com/reuters/ZWGK27AUJVKMPMFGVRIXPSV75E.jpg17:46
lastshellwell 2022 is going to suck17:48
BrainstormNew from r/Science: science: COVID-19 : Measuring viral RNA to predict which patients will die. Researchers were able to determine which biomarkers are predictors of mortality in the 60 days following the onset of symptoms. → https://old.reddit.com/r/science/comments/r3gxa1/covid19_measuring_viral_rna_to_predict_which/17:50
sacredebooks[m]This book will help the world defeat the corona virus COVID17:54
sacredebooks[m]https://eternalsacredbooks.wordpress.com/2021/11/27/everybody-can-become-world-champion-with-the-ultimate-godlike-of-love-foods-metric-system/17:54
sacredebooks[m]https://eternalsacredbooks.wordpress.com/everybody-can-become-world-champion-with-the-ultimate-godlike-of-love-foods-metric-system/17:54
Arsaneritmetric system?17:55
lastshelllMAO The minimum requirement need to obtain this ebook is a voluntary donation of 9999 USD or more.17:56
de-factolmao17:56
Arsaneritvoluntary requirement?17:56
lastshellexactly17:57
Arsaneritwhat's a voluntary requirement?17:57
lastshellis called nonsense17:57
Arsaneritmaybe this film from 2020 will become true https://www.imdb.com/title/tt12557882/?ref_=fn_al_tt_417:58
BrainstormNew from r/WorldNews: worldnews: Covid vaccine effective against new Omicron variant: South Africa's health minister → https://old.reddit.com/r/worldnews/comments/r3hflx/covid_vaccine_effective_against_new_omicron/18:09
Jigsy>Only the Fully Vaccinated should fear the New “Worst Ever” Covid-19 Variant; data shows they already account for 4 in every 5 Covid Deaths18:20
JigsyI have no idea what's going on anymore.18:20
lastshellJigsy ?\18:21
LjLJigsy, uh, the "new variant" is only prevalent in South Africa for now... is this 4-out-of-5 claim about South Africa?18:23
LjLi'd be surprised if there *were* many deaths from it (at least recognized ones) in the first place since they only started scrambling about a new variant 5 days ago18:24
JigsyThis is for the UK, apparently.18:27
Jigsyhttps://dailyexpose.uk/2021/11/27/only-the-fully-vaccinated-should-fear-the-new-variant/18:27
Jigsy%title18:27
BrainstormJigsy: From dailyexpose.uk: Only the Fully Vaccinated should fear the New “Worst Ever” Covid-19 Variant; data shows they already account for 4 in every 5 Covid Deaths – The Expose18:27
JigsyActually, I don't know.18:27
Jigsyhttps://www.bbc.co.uk/news/live/uk-5944350418:27
Jigsy%title18:27
BrainstormJigsy: From www.bbc.co.uk: Covid-19: PM says anyone arriving in UK must take PCR test - BBC News18:27
BrainstormNew from The Atlantic: We Know Almost Nothing About the Omicron Variant: As fall dips into winter in the Northern Hemisphere, the coronavirus has served up the holiday gift that no one, absolutely no one, asked for: a new variant of concern , dubbed Omicron by the World [... want %more?] → https://www.theatlantic.com/science/archive/2021/11/omicron-coronavirus-variant-what-we-know/620827/18:28
lastshellim scared now18:28
LjLJigsy, it is, unsurprisingly for that outlet, conflating two separate things18:35
LjLit's saying that 19% of all COVID deaths in the UK are among the unvaccinated - which may be true, i should look at other data18:35
LjLat the same time, it's talking about the new variant, but the new variant has only been found in the UK *today*, so it's definitely not talking about deaths from it18:36
LjLso forget about the new variant for now (although... don't forget it for too long, because it's definitely going to be a big problem)18:36
LjLwhat remains is, is 19% of the deaths being amoung the UNvaccinated something worrisome?18:36
LjLwell, the thing is18:36
LjL%cases uk18:36
BrainstormLjL: United Kingdom has had 10.1 million confirmed cases (15.2% of all people) and 145036 deaths (1.4% of cases) as of 2 hours ago. 358.7 million tests were done (2.8% positive). 50.9 million were vaccinated (76.6%). +49864 cases since 23 hours ago. See https://coronavirus.data.gov.uk/18:36
LjL51 million people are vaccinated, assuming i remember which number Brainstorm uses18:37
LjLthat may be only 76.6% of all people, but it's probably around 90% of *eligible* people18:37
LjLso this is one thing to consider: it's the usual "if 100% of the population were vaccinated, 100% of the deaths would be in the vaccinated, and 0% in the unvaccinated"18:38
LjLanother thing is, look at the other numbers they give too: "39% of all cases, 34% of all hospitalisations, and 19% of all deaths"18:38
LjLthere's an imbalance of cases vs deaths18:38
LjLthat's kind of counterintuitive18:38
LjLbut the thing is, unfortunately, *if* you get symptomatic and severe COVID despite being vaccinated, *then* your chances of dying are probably about the same as an unvaccinated person18:39
LjLbut first you must get it, and it must progress to being severe, which is avoided in many cases18:39
LjLit's easy to play with numbers in a way that's more scary than it should be. and, really, it's scary enough anyway18:39
LjLbut reaching the conclusion that it's the vaccinated who must fear is just terrible bad-faith journalism18:40
LjLnow let me reintroduce the new variant: *with it*, will the vaccinated need to fear? probably. it has a ton of mutations, there are decent chances it will evade the vaccine to some extent (i even suspect a large extent). but we don't really know, there haven't been enough cases to be able to tell. furthermore, even if the vaccinated will have to fear, that won't mean the unvaccinated *won't* have to fear...18:41
LjLit will still be as bad or worse for the unvaccinated. problem is, it may be bad for the vaccinated *too*18:41
BrainstormUpdates for Netherlands: +22074 cases (now 2.6 million), +55 deaths (now 19721) since 19 hours ago — Canada: +2973 cases (now 1.8 million), +15 deaths (now 29673) since 23 hours ago18:44
BrainstormNew from COVID on Twitter: Tulio de Oliveira (@Tuliodna): I think that the correct action would be to have a global fund that paid for the lost revenue to countries that are transparent and honest about their variants and epidemics. Tourism in South Africa is very important as provide much needed jobs and protect the [... want %more?] → https://twitter.com/Tuliodna/status/146464997743153561918:47
LjLbut anyway, bottom line: that article is engineered to scare you with a headline that's simply *false*, then you'll be too scared to make rational sense of the data (it's actually very long and detailed, just very misleading)18:53
BrainstormNew from r/WorldNews: worldnews: BioNtech says it needs 2 weeks to determine vaccine's effectiveness against Omicron → https://old.reddit.com/r/worldnews/comments/r3ikgp/biontech_says_it_needs_2_weeks_to_determine/18:56
joergLjL: or simplty, put that newspaper on the blacklist ;-)18:59
LjLwell for myself, yes, i immediately recognized as a terrible tabloid19:00
LjLbut it won't help others to simply tell them "that paper is on the blacklist, move on"19:00
joergkudos for your skills to explain and reassure19:01
edcbaWe are all going to die !!19:02
edcba...eventually of old age19:02
BrainstormUpdates for Italy: +12869 cases (now 5.0 million), +90 deaths (now 133627), +596898 tests (now 117.8 million) since a day ago19:09
edcba“It’s all speculation at this stage. It may be it’s highly transmissible, but so far the cases we are seeing are extremely mild,” she said.19:13
edcbafrom the guardian article19:13
edcbalooks nice19:13
edcbastill have to wait but still19:13
BrainstormNew from COVID on Twitter: Bijan Salehizadeh (@bijans): @fitterhappierAJ Yes. It's as if nobody reads the papers...critical NIH NHP study from a few weeks ago "Notably, we did not see increased TH1 or CD8+ 501 T cell responses in the BAL of vaccinated NHP compared to controls following challenge."  biorxiv.org/content/10.110… → https://twitter.com/bijans/status/146465755695409971419:15
LjLedcba, a contagious, immune-escaping variant that's actually milder would be interesting19:20
Arsaneritit seems vaccine development is quite fast (BioNTech said it needs 12 weeks to develop a vaccine specific to omicron), but vaccine approval is too slow.  How can vaccine approval be accelerated further?19:23
BrainstormUpdates for United Kingdom: +40087 cases (now 10.2 million), +131 deaths (now 145167) since 23 hours ago — Germany: +217 deaths (now 101271) since 23 hours ago19:34
BrainstormNew from r/WorldNews: worldnews: A former nurse who's anti-vaxx will face trial for organizing rallies protesting lockdowns in the UK → https://old.reddit.com/r/worldnews/comments/r3jde1/a_former_nurse_whos_antivaxx_will_face_trial_for/19:34
BrainstormNew from Politico: Airports: UK mandates masks, PCR tests for arrivals to stem Omicron seeding → https://www.politico.eu/article/johnson-omicron-coronavirus-variant-pcr-test-facemask/19:43
BrainstormNew from COVID on Twitter: Covid Fact Check UK (@fact_covid): I’ve been on an extended break and resisted the urge to Tweet for a long time now (3 months plus). I’ve been keeping a watchful eye on everything COVID related though, and thankfully nothing too dramatic has occurred in that time. → https://twitter.com/fact_covid/status/146466718607368193619:53
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): There is the moderbacher paper showing that naive t cells correlate with better outcomes.You cannot increase naive t cells with vaccination. → https://twitter.com/fitterhappierAJ/status/146466864269665075520:02
not_betelgeuse9Arsanerit: good point, likely not possible20:04
BrainstormNew from COVID on Twitter: Madhu Pai, MD, PhD (@paimadhu): Today, I want to give a big shout-out & thanks to colleagues in Africa who've been screaming for months about vaccine inequity and its consequences for the continentI stand by them in solidarity🙏🏾🙏🏾 @_HassanF @yodifiji @CKyobutungi @ekemma [... want %more?] → https://twitter.com/paimadhu/status/146467363385129779520:21
not_betelgeuse9might make sense for moderna to launch a worldwide effort to vaccinate ; esp since how the got their patents, and it being a PAN demic20:22
random-jellyfishomicron...why?20:47
LjL-Matrixbecause Nu sounded silly and maybe confusable with Mu which also exists20:48
LjL-Matrixand I have my pet theory on why not Xi, but i won't say it20:49
LjLArsanerit, approval could perhaps be made swifter but i don't think there is a *reasonable* way around the time needed to run a decent for safety20:52
LjLon the other hand, though, Pfizer and Moderna have been running such trials (on previous variants, like Beta and Delta) but they've quite been dragging them on20:52
LjLand i think that's a matter of where most of the money went (namely, to buy more of the same vaccine rather than fund the trials), not so much of intrinsic slowness20:52
LjLbut there is also a degree of intrinsic slowness, in that you do have to give yourself time to 1) make sure no really bad adverse effects develop, and 2) evaluate efficacy20:52
LjLthe fact that they can put an RNA string together in 12 weeks doesn't mean much in itself imo20:52
DreddHopefully some governments will be scared into bank rolling a new vaccine quickly this time21:04
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The speed of the response to Omicron has been far improved compared with the prior variants of concern, thanks to the scientists in Southern Africa. twitter.com/JeremyFarrar/s… pic.twitter.com/jaNu7SGM7i → https://twitter.com/EricTopol/status/146468757508440474021:17
de-factoSouth Africa should be rewarded for that, e.g. financially compensated for the economic loss they have to suffer by having warned us21:19
BrainstormNew from COVID on Twitter: BNO Newsroom (@BNODesk): NEW: Austria reports probable case of new coronavirus variant bnonews.com/index.php/2021… → https://twitter.com/BNODesk/status/146469345159795507721:37
BrainstormNew from r/WorldNews: worldnews: Hospital confirms first Czech case of new COVID strain → https://old.reddit.com/r/worldnews/comments/r3mtd9/hospital_confirms_first_czech_case_of_new_covid/22:15
Arsaneritde-facto: at the same time South Africa is complaining about travel restrictions22:16
de-factoof course they do, since their economy mainly is based on tourism22:16
de-factoWHO recommended against travel restrictions as they always do22:16
de-factoif they continue with such recommendations they undermine trust in sanity of their competence even more22:17
ArsaneritI was surprised to learn that vaccinated people flying to the EU do not need to show a negative test (unlike, for example, to the US)22:18
de-factobecause if the assumption would be that this is a problematic variant of concern, noone would understand why it was not contained after the fact it spread worldwide22:18
de-factoyeah fully vaccinated can enter the EU without test or quarantine, hence selecting for importing only those variants that easily can spread in fully vaccinated22:19
de-factosometimes i ask myself who designs such rules, they are completely stupid and fundamentally flawed22:20
Arsaneritapparently Canadians entering the US need a PCR test on the way in and on the way back to Canada, but if the visit is short they can use the same PCR test to return that they used to enter the US...22:20
de-factoimport another delta? whatever. Import a nasty evasive unknown VoC. disaster.22:20
ArsaneritWhat is the false negative rate of a good PCR test?22:21
ArsaneritIOW how risky is it to let people with negative PCR test run free?22:21
de-facto100% if samples are not taken properly?22:21
Arsaneritif samples are not taken properly it's not a good PCR test..22:21
de-factowhat if someone infected another passenger during flight?22:22
de-factoa properly taken PCR test will 100.00% show a negative result only a few hours after contamination22:22
de-factoa few days later, when the pathogen reproduction really kicks in though it may have a low CT value even22:22
Arsaneritok22:23
de-factowith banning intercontinental traveling one would not try to target the import of cases that are infected with an already circulating variant, those do not matter (as long as its circulating already)22:24
de-factothe goal would be to prevent import of a foreign unknown mutant and for such a single case slipping through safety measures already may be sufficient to start an initial cluster in the target population22:25
de-factoespecially if those tourists are being told that their test is negative, they may feel happy and  relieved that everything is fine and go for the next party, not even being aware that what they really are celebrating is the bootstrapping of a new variant at their place with seeding the initial cluster22:26
hateballsup coughers22:33
hateballhows ur omega22:33
BrainstormNew from r/Science: science: Some Ancient Maya Kingdoms Had Sustainable Agricultural Practices, High Food Yields. Using the high-resolution airborne LiDAR data, archaeologists have found extensive systems of sophisticated irrigation and terracing in and outside the ancient [... want %more?] → https://old.reddit.com/r/science/comments/r3n8kv/some_ancient_maya_kingdoms_had_sustainable/22:44
hateballLjL: did you ever consider https://www.youtube.com/watch?v=fbGug3rczx422:46
BrainstormNew from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): For the locales run by sociopaths or idiots who will keep schools open to seed and spread and uncharacterized variant, I offer the advice of masking and using airborne mitigations → https://twitter.com/fitterhappierAJ/status/146471329236295680722:54
LjLhateball, i am taking vitamin D, but i would be taking it regardless of COVID (although i'm probably forgetting it less), and generally speaking i guess i'm not too surprised you're linking Campbell given the tone he's taken in the past several videos since the time i was sometimes watching him in 202022:56
LjLalso the type of messages you sent on join... don't ;(22:56
hateballLjL: sorry if my type offends you22:58
LjLit does not particularly offend me, but i can't have it22:59
hateballyes no regular person can have 'it'22:59
BrainstormUpdates for Germany: +8680 cases (now 5.7 million), +170 deaths (now 101340) since 17 hours ago23:05
sdfgsdfgice cold salmon caviar is the best thing in the world23:06
sdfgsdfg.cases netherlands23:06
Brainstormsdfgsdfg: Netherlands has had 2.6 million confirmed cases (15.0% of all people) and 19721 deaths (0.8% of cases) as of 4 hours ago. 19.2 million tests were done (13.6% positive). 13.2 million were vaccinated (75.8%). +22074 cases, +55 deaths since 19 hours ago. See https://coronadashboard.government.nl/23:06
sdfgsdfg.cases south africa23:06
Brainstormsdfgsdfg: South Africa has had 3.0 million confirmed cases (5.0% of all people) and 89791 deaths (3.0% of cases) as of an hour ago. 19.4 million tests were done (15.3% positive). 17.0 million were vaccinated (28.9%). +3220 cases, +8 deaths since 23 hours ago. See https://offloop.net/covid19/?default=South%20Africa&legacy=no23:07
Brainstormsdfgsdfg: If you know of an official or otherwise good site for data about South Africa, with a reasonably short URL, please %tell LjL about it.23:07
hateballsdfgsdfg: a fine choice for foodw23:07
BrainstormNew from COVID on Twitter: Punctuated Equilibrium (3x💉) 🇮🇱 🇺🇸🇨🇼🇪🇬 (@GainOfDystopia): 🦠🚨🇮🇱 THE GATES ARE CLOSING TONIGHT:Israel is banning entry to stop Omicron:- All foreigners barred- Our Friends will reciprocate as expected- Air travel will largely stop- Quarantine [... want %more?] → https://twitter.com/GainOfDystopia/status/146472024052957593623:23
spokojni[m]oh no23:24
de-factovery good decision23:27
spokojni[m]why, it's just slowing the pandemic23:28
de-factolets see, i think they will be thankful for their leaders to do their job properly23:30
spokojni[m]Faster percentage of humanity is dead faster we are out of this pandemic, simple.23:30
de-factoit does not work like that23:30
BrainstormUpdates for India: +7619 cases (now 34.6 million), +46 deaths (now 467979) since 17 hours ago23:30
spokojni[m]No? :O23:30
spokojni[m]When will it end then?23:30
de-factowhen we end it23:31
spokojni[m]I ended it already in my brain23:31
spokojni[m]Have you?23:31
DreddOn the one hand, Israel closing up shop, at least temporarily till more is known, is probably a very good idea23:33
de-factowhen small children cover their eyes and assume they will become invisible it may still be cute, but if adults assume a pathogen will go away by just ignoring its presence it is a serious problem23:33
DreddOn the other hand in not an enormous fan of Israel and it's behaviour23:34
spokojni[m]de-factowell it will go away, eventually23:34
Dredds/On the other hand in not an enormous fan of Israel and it's behaviour/On the other hand i am not an enormous fan of Israel and it's behaviour/23:34
DreddLjL @LjL:libera.chat: isn't vitamin D in most multivitamins?23:35
BrainstormNew from r/WorldNews: worldnews: New Covid variant called omicron not Xi to avoid offending Chinese ruler → https://old.reddit.com/r/worldnews/comments/r3omkj/new_covid_variant_called_omicron_not_xi_to_avoid/23:42
de-factoalso why are the Dutch testing the passengers of the two flights that arrived from SA?23:49
TimvdeTo check for omicron, I suppose?23:50
de-factodoes that mean if 61 our of 600 passengers tested positive that the other 539 will be let home under the impression that they did not catch it?23:50
de-factoargh :///23:50
TimvdeLikely :P23:50
spokojni[m]Omicron sounds better than delta, more sinister23:50
de-factothey should have isolated all of them for two weeks, regardless if they test positive NOW or not23:51
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): More of the same. but central message; patience. Data is not as bad as could have been, in a few weeks there will be enough to know:- infectiousness- pathogenicity- evasion of neutralising antibodies.science.org/content/articl… → https://twitter.com/Marc_Veld/status/146472784702990745923:52
spokojni[m]de-facto guess they can't be arsed about that23:52
de-factothey are importing it to EU right now23:52
TimvdeWe did it first!23:53
spokojni[m]damn, we are all going to die. Aren't we23:53
TimvdeNah23:53
TimvdeWe don't even know if it's more dangerous yet23:53
de-factowe will know soon how it competes in our population against Delta23:54
TimvdeYep23:54
de-factobut by then it will be too late to contain it23:54
de-factoits imported TODAY23:55
aann"human nature"23:55
de-factowhat really makes me mad about this?23:55
Timvdede-facto: if it's more contagious but less dangerous, it may be a good thing? (that's two big ifs though)23:55
de-factoits imported AFTER the fact about the knowledge that this most likely may be an evasive nasty VoC23:55
de-factothats a gigantic IF23:56
TimvdeYes, it was more of a question actually23:56
aannthink I saw 1 cloth mask in the stands of 100k people @Michigan fball game today23:57
de-factowe dont know yet, and until we do we should treat that under the assumption that it will fulfill the potential bad expectations23:57
ublxeven if it's not more dangerous, the more contagious aspect multiplies the petri dish install base aspect23:57
de-factoTimvde, yeah i speculated about that yesterday too, what if some of the mutations also destroyed its superantigenic properties or something like that23:58
LjL<spokojni[m]> Faster percentage of humanity is dead faster we are out of this pandemic, simple.23:58
LjLplease read the channel guidelines in the topic23:58
LjLremarks like those are not appreciated23:58
spokojni[m]sorry23:58
LjLDredd, i don't think most multivitamins have vitamin D, but even if they do, it's unlikely to be stored in fat (usually oil) as the "medical-grade" typically is, and i bet they aren't going to give you 1000IU or more per day which is the standard23:59
LjLmultivitamins are... maybe somewhat useful sometimes, i guess :P23:59
LjLi think most vitamins probably shouldn't be supplemented unless there's a *known* deficiency23:59
LjLbut for vitamin D, we know that the vast majority of people have a deficiency, at least in the winter23:59

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