| de-facto | that is so far, we dont really know about the new Omicron | 00:00 |
|---|---|---|
| de-facto | but since T-cells recognize smaller parts of the antigen it may be that they dont react too much differently even with a variant as highly mutated as Omicron | 00:00 |
| de-facto | that may not hold for the adaptive immune system, hence antibodies produced by the B-cells quite likely would not fit properly on Omicron when they were raised against the almost 2 year old Wuhan-Hu-1 variant of the s-protein | 00:01 |
| squirrel | yeah but more broadly.. will it let up in a year? two? ten? will there be still lockdowns? imagine omicron didn't happen, and no new mutations ever happen, can we be sure it gets better then? | 00:05 |
| Brainstorm | New from r/WorldNews: worldnews: Germany: Dozens take illegal mystery COVID vaccine before police shut it down → https://old.reddit.com/r/worldnews/comments/r4gnq0/germany_dozens_take_illegal_mystery_covid_vaccine/ | 00:06 |
| random-jellyfish | things will get better only if over 80% of the world population gets immunised | 00:06 |
| random-jellyfish | otherwise new strains will appear all the time | 00:07 |
| squirrel | can 80% prevent new strains effectively? | 00:07 |
| random-jellyfish | people in reach countries will probably build a strong collective immunity by 2024 and won't care about new strains more than they care about the flu | 00:07 |
| random-jellyfish | immunocompromised folks should receive most attention, especially HIV positives, they are creating a very large number of mutations | 00:09 |
| squirrel | i don't think there's a collective immunity from flu? | 00:09 |
| random-jellyfish | they need to get vaccinated and have their antiviral treatment given properly | 00:09 |
| random-jellyfish | squirrel people don't die from the flu like they do from covid | 00:10 |
| random-jellyfish | that's because of immunity | 00:10 |
| random-jellyfish | our immune systems are trained to produce new anti-flu antibodies fast, even if there are new strains every year | 00:11 |
| TheForgottenO-BL | random-jellyfish: the vaccine doesnt immunise from anything. thats why most covid hospital patients are vaccinated | 00:11 |
| TheForgottenO-BL | another thing is they cant isolate the mutations, so they cant claim this one is anywhere, or that it even exists | 00:12 |
| random-jellyfish | TheForgottenO-BL "hats why most covid hospital patients are vaccinated" where did you get that info? | 00:12 |
| random-jellyfish | and in which country | 00:12 |
| TheForgottenO-BL | not to mention what the vaccinations actually are doing | 00:12 |
| random-jellyfish | in my country most ICU beds are taken by unvaccinated | 00:12 |
| joerg | squirrel: corona will get endemic, everybody will build up immune competence, either by vaccination or by infection. Not a sterile immunity, so we'll see a certain not really concerning "noise floor" of constant covid cases, each winter | 00:13 |
| * TheForgottenO-BL uploaded an image: (80KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/mNSkbcJPGSQXHmSwONoXWApl/BvRymGwL.jpeg > | 00:13 | |
| TheForgottenO-BL | no. they are not. go there in person and see | 00:13 |
| TheForgottenO-BL | i bet the hospital parking lot is mostly empty | 00:13 |
| random-jellyfish | TheForgottenO-BL I see where you're coming from...I'll stop arguing with you.. | 00:13 |
| * TheForgottenO-BL uploaded an image: (174KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/gIEAbxnklwrpmFEvOeaHZYhP/signal-2021-11-08-22-24-55-294.png > | 00:14 | |
| * TheForgottenO-BL uploaded an image: (84KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/oUjsfBaHBUhbZLMfUQrCBzke/PchlZ1gv.png > | 00:14 | |
| random-jellyfish | can the mods do something about antivaxxer propaganda? do we really need that in here? | 00:14 |
| joerg | LjL: ^^^ +1 | 00:15 |
| joerg | was about to write a similar note | 00:15 |
| Telvana | lol, hivemind. | 00:15 |
| * TheForgottenO-BL uploaded an image: (193KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/GmsyGEItIPwtmUxtcSJsXaUT/C5HyFBCf.jpeg > | 00:15 | |
| TheForgottenO-BL | when the inventor of mRNA comes out, and tells you Not to get the vaccine, what do you do? | 00:16 |
| random-jellyfish | can someone ban this person? | 00:17 |
| de-facto | of course they isolated Omicron, thats why it raised eyebrows after it was sequences because it contains up to 32 mutations on the s-protein alone (10 of which are in the receptor binding domain) | 00:17 |
| Telvana | Why? Because he doesn't follow your narrative? Isn't everyone allowed an opinion? | 00:17 |
| * TheForgottenO-BL uploaded an image: (74KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/WDIddLqUUeDRaUlwpxvRfTWl/N2kmK1dx.jpeg > | 00:18 | |
| Telvana | de-facto: the hope is that it's finally mutating to be less deadly, of course. | 00:19 |
| * TheForgottenO-BL uploaded an image: (51KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/TECMvwqIhvlPOLZULGcBOJrl/it8rrkVb.jpeg > | 00:19 | |
| Telvana | It's not beneficial for a virus to continuously kill it's hosts | 00:19 |
| Telvana | *its | 00:19 |
| TheForgottenO-BL | thats true. it isnt anything near what it used to be | 00:19 |
| TheForgottenO-BL | no denying that | 00:19 |
| de-facto | their PCR test in SA used several target sequences, one of which was in the s-protein and did stop to work with Omicron (so called s-gene-dropout) because the other (two?) still worked, so every PCR test that came back positive for the other primers but had that s-gene dropout (due to a mutation in Omicron preventing that particular primer to fit onto that sequence) turned out to be a case of Omicron (they did full sequences of it) | 00:20 |
| Telvana | Sadly, we don't know how many times it will mutate before it actually does that, or if it even will | 00:20 |
| LjL | TheForgottenO-BL, this nonsense is not acceptable here | 00:20 |
| LjL | stop or leave | 00:20 |
| squirrel | <random-jellyfish> our immune systems are trained to produce new anti-flu antibodies fast, even if there are new strains every year | 00:20 |
| * TheForgottenO-BL uploaded an image: (140KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/GtlEYvmPQOWWKdUfDHBWwbIm/hV4b0WlJ.png > | 00:20 | |
| squirrel | i read that this is absolutely not the case tho? | 00:20 |
| de-facto | that demonstrates that PCR primers easily can be designed to distinguish between the variants (only fit onto a combination of genes specific to that variant only) | 00:20 |
| squirrel | source pls | 00:21 |
| TheForgottenO-BL | August 17th. | 00:21 |
| de-facto | every test of course could be re-verified with a full sequence (but that is quite expensive and takes quite some time) | 00:21 |
| de-facto | i bet that is what they are doing right now in SA though | 00:21 |
| de-facto | they upload those sequences to publicly accessible databases such as GISAID | 00:21 |
| de-facto | so other bioinformatic researchers could access those and do their analysis in things | 00:22 |
| Telvana | de-facto: Fun fact: It's basically a text file | 00:22 |
| de-facto | yeah FASTA | 00:22 |
| Telvana | yep, it's really neat to *see* something like that | 00:22 |
| Telvana | It's completely meaningless to me, but there are smarter folks who can make sense of it :p | 00:22 |
| de-facto | some of those sequences can be seen analyzed at https://nextstrain.org/groups/neherlab/ncov/21K | 00:22 |
| de-facto | that would be Omicron (they call it 21K on their platform) | 00:23 |
| Telvana | It's crazy for me to think that you can basically feed a text file into a machine and pop out a vaccine | 00:23 |
| Telvana | (that is VERY simplified, of course) | 00:23 |
| squirrel | 3d print your own vaccine | 00:23 |
| Telvana | What could go wrong? lol | 00:24 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Newsnodes - B.1.1.529 tracker ( https://www.zotero.org/groups/covid_links/items/2VPM5JDJ ) | 00:24 | |
| Telvana | We would have zombies in a week if they allowed that | 00:24 |
| Telvana | :p | 00:24 |
| Telvana | (meaning, if they just allowed anyone to make one) | 00:25 |
| random-jellyfish | it's very disappointing to see people confusing the aggressive and callous spread of misinformation with opinions | 00:25 |
| squirrel | apparently "omicron" is an anagram of "moronic" | 00:25 |
| Brainstorm | New from r/WorldNews: worldnews: COVID-positive Czech Republic President appoints Prime Minister from transparent box → https://old.reddit.com/r/worldnews/comments/r4gvu8/covidpositive_czech_republic_president_appoints/ | 00:25 |
| random-jellyfish | misinformation is not an opinion, especially when it's intentional or pushed forward aggressively and arrogantly | 00:25 |
| LjL | TheForgottenO-BL, for the record, "the inventor of mRNA" is nature, but even if i read what you meant and not what you wrote, that person is *not* the main inventor of the technology involved with the vaccines | 00:26 |
| Telvana | lol, squirrel - at this point the fact that we're still stuck in this because of stupidity - is literally moronic, and, at this point, we're not getting out of it anytime soon | 00:26 |
| LjL | but as always with people with your sort of rhetoric, you come up with things like "the inventor of mRNA said not to take the vaccine", and when doing that it's convenient not to even state who it is (or if stated, make it come with a big screenshot of an article, any article, where he is called such in the headline) | 00:27 |
| Telvana | The main issue with this virus as most of you probably know is the fact that it has an animal reservoir, that's the rub with this | 00:27 |
| LjL | Telvana, you mean several ;( | 00:27 |
| Telvana | LjL: correct | 00:27 |
| random-jellyfish | Telvana https://www.jnj.com/innovation/the-5-stages-of-covid-19-vaccine-development-what-you-need-to-know-about-how-a-clinical-trial-works | 00:27 |
| Telvana | USA has an issue with deer + covid | 00:27 |
| Telvana | And likely it's possible it could mutate in them as well and jump back to us. | 00:28 |
| LjL | Telvana, i expect cats to become a pressing issue if/when we manage to drastically reduce circulation in hoomans | 00:28 |
| Telvana | LjL: yeah | 00:28 |
| Telvana | Big cats, mainly. | 00:28 |
| random-jellyfish | if the deer develop herd immunity it won't be a problem | 00:28 |
| Telvana | It seems so far domestics are okayy | 00:28 |
| de-facto | well to be fair bats are the natural reservoir of many tens of thousands of different CoVs, quite some with pandemic potential | 00:28 |
| Telvana | of course, de-facto | 00:29 |
| de-facto | so we (as a race) should just stay away from those | 00:29 |
| Telvana | and STOP EATING THEM | 00:29 |
| Telvana | *cough* | 00:29 |
| Telvana | Oh wait, coughing in a covid channel, sorry | 00:29 |
| Telvana | :p | 00:29 |
| * LjL offers Telvana a KF94 | 00:30 | |
| LjL | (sorry, the Auras are just too expensive, i'm keeping them) | 00:30 |
| Telvana | I am in a unique position with my current job in that I have to make decisions based on experts knowledge, and some of those experts are biased, so I have to dig through the bias to get to the truth of the matter (I work for a local EMA/health department) | 00:31 |
| squirrel | anyone's bothering with the masks such as kf94/n95 here? | 00:31 |
| Telvana | squirrel: I do, but only because I don't personally believe cloth works | 00:31 |
| Telvana | It's better than nothing, and at this point, since nobody is wearing a mask anymore, if you're going to wear one, you might as well wear one that only protects yourself | 00:32 |
| * de-facto serves Telvana a shot of "Melissa Spirit" containing 80% ethanol with a mischievous grin :D | 00:32 | |
| squirrel | i have a box of these surgical masks, the ones that you tie on the back of your head | 00:32 |
| squirrel | found it on the street | 00:33 |
| squirrel | everybody wearing masks here tho | 00:33 |
| random-jellyfish | Telvana "Why? Because he doesn't follow your narrative? Isn't everyone allowed an opinion?" - that's not "my" narrative | 00:33 |
| Telvana | The amount of data I had to wade through about masks in the beginning of this was maddening, bt | 00:33 |
| Telvana | w | 00:33 |
| de-facto | i am wearing at least FFP2 (N95) if not FFP3 (N100) in crowded indoor places | 00:34 |
| Telvana | I used to wear a full face respirator at one point | 00:34 |
| squirrel | :0 | 00:34 |
| Telvana | Then it got to the point where it felt silly | 00:34 |
| Telvana | So, the N95 will suffice at this point | 00:34 |
| squirrel | i am vaccinated so i'm not afraid to get sick | 00:34 |
| de-facto | yeah ... most likely not | 00:35 |
| Telvana | I can't be vaccinated due to being HIGHLY allergic to the carrier (PEG) | 00:35 |
| de-facto | what about Janssen then? | 00:35 |
| Telvana | And J&J has been ruled out due to blood clots issues that run in my family | 00:35 |
| de-facto | oh | 00:35 |
| Telvana | (These are all doctor recommended, btw, I didn't make these choices myself) | 00:36 |
| Telvana | I am also relatively young, and not at risk either - so I just wear a mask, wash my hands, and stay the hell away from people | 00:36 |
| squirrel | isn't peg like a common thing | 00:36 |
| Telvana | squirrel: it is, and it's a pain to be allergic to it | 00:36 |
| squirrel | damn that sux | 00:37 |
| Telvana | If I get it on my skin I break out in hives | 00:37 |
| Telvana | Oddly, I was never allergic to it till I spent time in Iraq, so who knows what triggered it | 00:37 |
| Telvana | Luckily it's looking like we'll have a nasal vaccine soon - if the trials all work out well, etc | 00:38 |
| squirrel | i was never allergic to pollen until i one day woke up and then i was | 00:38 |
| Telvana | Allergies are strange, they really are | 00:38 |
| squirrel | it just happens i guess | 00:38 |
| Telvana | And it's frustrating because I'd be vaccinated already if it weren't for annoying reasons | 00:38 |
| Telvana | but, such is life, and the good news about all of it is that we've got effective treatments coming down the pipe | 00:39 |
| Telvana | In all honesty, I've always thought that an effective treatment was our way out of this | 00:39 |
| squirrel | and now u have to deal with people who go like “oh yeah, you have /medical/ reason, yeah” | 00:39 |
| de-facto | i was allergic to house dust, so i just ignored it and now i am not anymore :P | 00:39 |
| Telvana | vaccinations are nice and all, but the logistics and push-back made it impossible to get to 80% | 00:39 |
| Telvana | So, here's to hoping the pill solves at least a good portion of the deaths / major illness | 00:40 |
| Telvana | being allergic to house dust would be maddening | 00:42 |
| Telvana | you can't get away from that lol | 00:42 |
| random-jellyfish | dust mites seem to contribute to that | 00:44 |
| de-facto | hence i did not and it calmed down | 00:46 |
| de-facto | yeah i am a bit skeptical about those pills, especially the one that induces a fatal mutation cascade in SARS-CoV-2 | 00:46 |
| de-facto | so there are two extreme cases 1) SARS-CoV-2 replicating with high fidelity (making only very few mistakes thanks to its proofreading enzymes) 2) the mutations induced by the med are so many that the resulting sequence is broken beyond repairs (fatal mutation cascade) | 00:46 |
| de-facto | but what is the grayzone in between those two? | 00:47 |
| Telvana | That's the question more people should be asking | 00:47 |
| Telvana | And not to knock the vaccine, but it's also got some issues with mutations as well - not to mention the plethora of other things that mutate this | 00:48 |
| Telvana | HIV patients, immunocompromised, etc | 00:48 |
| Telvana | I am not 100% certain on the mechanics of how HIV patients can catch COVID and mutate it ridiculously badly works, though | 00:49 |
| Telvana | https://www.biospace.com/article/south-african-hiv-patient-was-a-natural-laboratory-for-sars-cov-2-mutations/ | 00:51 |
| Telvana | That somewhat explains it, but there is a lot lacking in *why* and *how* | 00:51 |
| de-facto | initial contamination usually happens with only a few (of the most fit) virions of someone shedding "their best versions" of it | 00:51 |
| Brainstorm | New from r/WorldNews: worldnews: Botswana says four foreign diplomats who tested positive for COVID-19 on Nov 11th upon leaving the country are confirmed to have been infected with the Omicron variant → https://old.reddit.com/r/worldnews/comments/r4hlqr/botswana_says_four_foreign_diplomats_who_tested/ | 00:53 |
| de-facto | then the infection begins to replicate, from time to time a mutation that is not a significant disadvantage survives (branches off its ancestors) and thereby the phylogenetic tree begins to grow in variety emerging from its root of very low variety (the initial contamination) | 00:57 |
| de-facto | the longer such a viral replication is allowed to continue (without the compromised immune system being able to kill it off) the more time it has to accumulate more and more mutations | 01:01 |
| de-facto | all the variants emerging from the branches of that phylogenetic tree compete for the same resources in that host, but only the most (replication) fit (under the given conditions such as non neutralizing immune pressure) will survive hence after long incubation time be able to shed and infect another susceptible individual | 01:02 |
| Telvana | What's worrying to me in a situation like that is - it doesn't seem that it's a mutation that's naturally beneficial to the virus, so it could be any manner of outcomes from it - could be nothing, could be detrimental to the host | 01:06 |
| de-facto | most infection chains end at some point (e.g. someone getting symptomatic, get tested and isolates before passing it on) but some of them will end up in a cluster event eventually (when conditions allow for that) and if that happens for such a highly mutated version it may be the epicenter for a new variant | 01:06 |
| de-facto | well if it was an infection that was going on for long time in that immuno-comprimised host it surely did not kill it | 01:11 |
| de-facto | at least not at the time it jumped to the next host from it | 01:11 |
| rpifan | so is omicron gonna fuck us all u | 01:21 |
| genera | so they report their patient was pcr-positve for 216 days. this still feels like an outside reservoir, no? | 01:29 |
| Brainstorm | New from r/WorldNews: worldnews: Pandemic to cost global tourism $2 trillion in 2021, U.N. says → https://old.reddit.com/r/worldnews/comments/r4ip53/pandemic_to_cost_global_tourism_2_trillion_in/ | 01:50 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: COVID-19 reinfection tracker ( https://www.zotero.org/groups/covid_links/items/2ML4DME2 ) | 01:54 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Tracking COVID-19 variant Omicron ( https://www.zotero.org/groups/covid_links/items/VY8YZYLA ) | 01:54 | |
| joerg | Telvana: ((allergic)) quite unfortunate. I feel with you | 02:02 |
| Brainstorm | New from r/WorldNews: worldnews: Swiss vote to approve COVID restrictions as infections rise. Swiss voters have given clear backing to legislation that introduced special COVID-19 certificates under which only people who have been vaccinated, recovered or tested negative can [... want %more?] → https://old.reddit.com/r/worldnews/comments/r4j32z/swiss_vote_to_approve_covid_restrictions_as/ | 02:09 |
| joerg | Telvana: do you know details about the nasal vaccine stuff? would be a mega achievement, also because _that_ actually has much higher chances to provide sterile immunity | 02:09 |
| LjL | <Telvana> It's better than nothing, and at this point, since nobody is wearing a mask anymore, if you're going to wear one, you might as well wear one that only protects yourself ← wait what, an N95/KF94/FFP2 masks doesn't "only protect yourself". that's a terrible misconception. ones *with valves* arguably do (although that really could be argued), but regular ones are at least as good as surgical or cloth masks at protection yourself *and others* | 02:11 |
| LjL | i don't know why some people have come up with this idea that they "only protect you". the message that was being sent was that *they protect you* and not just others, the idea wasn't "they don't protect others" | 02:12 |
| LjL | in fact some countries have *mandated* those masks | 02:12 |
| LjL | <Telvana> Why? Because he doesn't follow your narrative? Isn't everyone allowed an opinion? ← an opinion made up mainly of posting big pictures is spam, and if it's not spam it's at least overwhelming rather than being actual sources that you can click and investigate, and then there were "clever" things like the usual "the inventor of mRNA said you shouldn't take the vaccine", which is standard anti-vax propaganda and flat-out wrong. no, they aren't allowe | 02:14 |
| LjL | d this kind of "opinions" in here. | 02:14 |
| de-facto | Some report prices of 620€ (700$) for a 5 day dose of Paxlovid (PF-07321332) thats about one third of the cost for a monoclonal antibody therapy | 02:31 |
| Telvana | LjL: I made that comment long before I wound up having to ignore him for being spammy and annoying, btw. | 03:07 |
| Telvana | Believe me, I see those kinds of people every day in my line of work | 03:07 |
| Telvana | LjL: as for the masks I was talking about I am talking about the facial respirators that I have worn, those don't protect anyone else but yourself as the vent on the bottom of it blows out unfiltered air, so no, those don't protect anyone but yourself | 03:09 |
| de-facto | .title https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001005 <-- really neat paper about viral evolution and quasispecies theory | 03:24 |
| Brainstorm | de-facto: From journals.plos.org: Quasispecies Theory and the Behavior of RNA Viruses | 03:24 |
| Brainstorm | Updates for United Kingdom: +36574 cases (now 10.2 million) since 11 hours ago — Netherlands: +22185 cases (now 2.6 million) since 23 hours ago | 03:30 |
| Brainstorm | New from Reddit (test): Covid2019: Wastewater surveillance demonstrates high predictive value for COVID-19 infection on board repatriation flights to Australia → https://old.reddit.com/r/Covid2019/comments/r4k4kw/wastewater_surveillance_demonstrates_high/ | 03:43 |
| Brainstorm | New from The Indian Express: World: South Africa to remain on lowest lockdown level; calls for immediate end to travel ban → https://indianexpress.com/article/world/south-africa-to-remain-on-lowest-lockdown-level-calls-for-immediate-end-to-travel-ban-7646558/ | 03:53 |
| Brainstorm | New from Politico: Coronavirus: Boris Johnson faces old dilemma on new coronavirus variant → https://www.politico.eu/article/omicron-uk-boris-johnson-coronavirus-variant-pandemic-restrictions/ | 04:02 |
| Brainstorm | New from NPR: As omicron spreads, studies suggest that travel bans alone don't do much good: Public health experts warn that the rush to impose travel bans on southern African countries after the omicron variant was identified can work against scientific transparency. → https://www.npr.org/sections/coronavirus-live-updates/2021/11/28/1059619823/omicron-travel-bans-covid | 04:12 |
| Brainstorm | New from The Indian Express: World: South Africa mulling compulsory Covid-19 jabs for some places, activities → https://indianexpress.com/article/world/south-africa-covid-19-vaccine-restrictions-omicron-7646614/ | 05:00 |
| Brainstorm | New from r/WorldNews: worldnews: Young people bearing brunt of Covid-19 resurgence, ICU doctor warns → https://old.reddit.com/r/worldnews/comments/r4mqdj/young_people_bearing_brunt_of_covid19_resurgence/ | 05:09 |
| Brainstorm | New from The Indian Express: World: WHO reaches draft consensus on future pandemic treaty → https://indianexpress.com/article/world/who-draft-consensus-future-pandemic-treaty-covid-19-7646656/ | 05:28 |
| Brainstorm | Updates for Germany: +23325 cases (now 5.8 million) since 23 hours ago — India: +8309 cases (now 34.6 million), +236 deaths (now 468790), +1179373 tests (now 639.4 million) since 23 hours ago | 05:35 |
| joerg | Germany new cases 29364 (MINUS 1279 vs 1 week ago) - great, the trend continues re [28 Nov 2021 09:03:56] <joerg> >><sdfgsdfg> could they see 200k a day ? << nope, I think there's a trend change. incidences increase slowed down from >30% to 5% to 2% and soo should go down | 06:17 |
| Brainstorm | New from r/WorldNews: worldnews: New Zealand to ease COVID measures this week despite Omicron threat - PM → https://old.reddit.com/r/worldnews/comments/r4nv98/new_zealand_to_ease_covid_measures_this_week/ | 06:25 |
| Brainstorm | Updates for Lombardy, Italy: +2493 cases (now 929470), +5 deaths (now 34349) since a day ago — Atacama, Chile: +1 deaths (now 370) since a day ago | 06:43 |
| Brainstorm | New from Virological.org: Latest posts: Mutagenic antivirals: the evolutionary risk of low doses: Image: Pexels/ Pixabay Chase W. Nelson 1 , Sarah P. Otto 2 Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA; cnelson@amnh.org Department of [... want %more?] → https://virological.org/t/mutagenic-antivirals-the-evolutionary-risk-of-low-doses/768/1 | 07:02 |
| Brainstorm | New from The Indian Express (Health): Fashion: From shades, styles to silhouettes: Designers pick best moments from Paris, London, Milan and New York fashion weeks → https://indianexpress.com/article/lifestyle/fashion/paris-london-milan-and-new-york-fashion-weeks-7595514/ | 08:08 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Swiss vote to approve COVID restrictions as infections rise. Swiss voters have given clear backing to legislation that introduced special COVID-19 certificates under which only people who have been vaccinated, recovered [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/r4q2k9/swiss_vote_to_approve_covid_restrictions_as/ | 08:46 |
| Brainstorm | New from r/WorldNews: worldnews: Covid-19 live updates: Omicron variant found in Canada as cases emerge around the world → https://old.reddit.com/r/worldnews/comments/r4qk5m/covid19_live_updates_omicron_variant_found_in/ | 08:56 |
| Brainstorm | New from Science-Based Medicine: Are the FDA’s VRBPAC and the CDC’s ACIP hopelessly compromised by conflicts of interest over COVID-19 vaccines?: The FDA's VRBPAC and the CDC's ACIP are the two main committees that approve [... want %more?] → https://sciencebasedmedicine.org/are-the-fdas-vrbpac-and-the-cdcs-acip-hopelessly-compromised-by-conflicts-of-interest-over-covid-19-vaccines/ | 09:05 |
| Brainstorm | New from r/WorldNews: worldnews: COVID-19: Six Omicron variant cases detected in Scotland, authorities say → https://old.reddit.com/r/worldnews/comments/r4r0o7/covid19_six_omicron_variant_cases_detected_in/ | 09:24 |
| Brainstorm | Updates for Hungary: +27830 cases (now 1.1 million), +460 deaths (now 34326), +124615 tests (now 8.4 million) since 2 days ago | 09:37 |
| imaginary | %cases czechia | 09:38 |
| Brainstorm | imaginary: Czechia has had 2.1 million confirmed cases (19.9% of all people) and 32929 deaths (1.5% of cases) as of 2 hours ago. 43.5 million tests were done (4.9% positive). 6.6 million were vaccinated (61.9%). +9321 cases, +92 deaths since 23 hours ago. See https://onemocneni-aktualne.mzcr.cz/covid-19 | 09:38 |
| AlexeyX | Hi there! | 09:49 |
| sdfgsdfg | whats poppin | 10:09 |
| Brainstorm | Updates for Germany: +23324 cases (now 5.8 million) since 23 hours ago | 10:39 |
| Brainstorm | New from StatNews: With winter looming, cancer patients and doctors seek more Covid protection: Even with third and fourth Covid vaccine doses for immunocompromised people, protection can be uncertain. Some have their eyes on monoclonal antibody treatments. → https://www.statnews.com/2021/11/29/monoclonal-antibodies-covid-protection-cancer-patients-doctors/ | 10:49 |
| Brainstorm | New from ProPublica: They Knew Industrial Pollution Was Ruining the Neighborhood’s Air. If Only Regulators Had Listened.: by Lisa Song , with additional reporting by Ava Kofman , photography by Kathleen Flynn , special to ProPublica [... want %more?] → https://www.propublica.org/article/they-knew-industrial-pollution-was-ruining-the-neighborhoods-air-if-only-regulators-had-listened#1172990 | 11:18 |
| Brainstorm | New from Politico: Coronavirus: COVID booster jabs available for all Brussels residents over 18 → https://www.politico.eu/article/coronavirus-booster-vaccines-available-all-brussels-residents-over-18/ | 11:56 |
| Brainstorm | New from The Indian Express: World: Merriam-Webster chooses vaccine as the 2021 word of the year → https://indianexpress.com/article/world/merriam-webster-chooses-vaccine-2021-word-of-the-year-7647378/ | 12:06 |
| Brainstorm | Updates for France: +34 cases (now 7.7 million) since 14 hours ago | 12:07 |
| sdfgsdfg | where are the omicron case numbers | 12:19 |
| sdfgsdfg | wheres daily comparison | 12:19 |
| sdfgsdfg | it's so exciting we need more data | 12:20 |
| Brainstorm | Updates for Nepal: +243 cases (now 821121), +1 deaths (now 11524), +7231 tests (now 4.6 million) since 23 hours ago | 12:31 |
| Dredd | "exciting" is one word for it | 12:37 |
| Brainstorm | New from r/WorldNews: worldnews: Taiwanese man stabs convenience store clerk to death over reminder to wear face mask → https://old.reddit.com/r/worldnews/comments/r4tta3/taiwanese_man_stabs_convenience_store_clerk_to/ | 12:44 |
| Brainstorm | New from The Indian Express: World: Germany: Dozens take illegal mystery COVID vaccine before police shut it down → https://indianexpress.com/article/world/germany-illegal-mystery-covid-vaccine-police-7647380/ | 12:53 |
| zutt | according to Finnish health institute, theres now more people hospitalized from covid than ever before (fewer in intensive care than before tho) | 12:57 |
| zutt | %cases finland | 12:57 |
| Brainstorm | zutt: Finland has had 185622 confirmed cases (3.4% of all people) and 1309 deaths (0.7% of cases) as of 50 minutes ago. 7.9 million tests were done (2.4% positive). 4.3 million were vaccinated (77.5%). +3338 cases, +29966 tests since 2 days ago. See https://offloop.net/covid19/?default=Finland&legacy=no | 12:57 |
| Brainstorm | zutt: If you know of an official or otherwise good site for data about Finland, with a reasonably short URL, please %tell LjL about it. | 12:57 |
| zutt | 15k confirmed cases in last 14 days :F | 12:59 |
| zutt | to think that last years summer, we were at 0-2 cases per day, and we're now up to 1k cases per day.. | 13:00 |
| sdfgsdfg | that's about 1000 daily, same as Melbourne's population - same number | 13:00 |
| sdfgsdfg | we've been covid zero for almost 2 yrs with tiny fk ups until delta | 13:01 |
| sdfgsdfg | if the prophecy is right about omicron, this could be just the beginning | 13:02 |
| zutt | yeah, hard to say yet | 13:10 |
| sdfgsdfg | I still think the media is slightly milking the attention though | 13:10 |
| zutt | as usual yeah, I don't really trust the news about covid here - our health institute reports what I need to know and whats relevant | 13:11 |
| de-facto | https://bnonews.com/index.php/2021/11/omicron-tracker/ https://newsnodes.com/nu_tracker | 13:17 |
| de-facto | sdfgsdfg, ^^ Omicron case numbers | 13:17 |
| Brainstorm | New from COVID on Twitter: *Walter Bloomberg (@DeItaone): MODERNA CEO STEPHANE BANCEL ON OMICRON VARIANT SAYS IT WILL BE MONTHS BEFORE OMICRON SPECIFIC VACCINES CAN BE SHIPPED - CNBC$MRNA → https://twitter.com/DeItaone/status/1465293749702074368 | 13:22 |
| de-facto | ^^ hence stop importing it into countries | 13:23 |
| Brainstorm | Updates for Germany: +21671 cases (now 5.8 million) since 23 hours ago | 13:34 |
| Brainstorm | New from Johnson&Johnson: (news): Johnson & Johnson to Evaluate Its COVID-19 Vaccine Against New Omicron COVID-19 Variant → https://www.jnj.com/johnson-johnson-to-evaluate-its-covid-19-vaccine-against-new-omicron-covid-19-variant | 14:00 |
| sdfgsdfg | this thing has been around for definitely more than a week or two, about 100-200 cases sounds insignificant | 14:00 |
| Brainstorm | New from The Indian Express: World: BioNTech starts work on Omicron-specific vaccine → https://indianexpress.com/article/world/biontech-omicron-specific-vaccine-7647739/ | 14:10 |
| Brainstorm | New from COVID on Twitter: Claudia Sahm (@Claudia_Sahm): Zients should never have been the White House's lead on Covid. same with Sperling on Rescue Plan. BOTH should resign, so Admin can hit restart.we need experts, not political operatives leading. twitter.com/JuliaRaifman/s… → https://twitter.com/Claudia_Sahm/status/1465309303603142663 | 14:29 |
| Brainstorm | Updates for Switzerland: +14715 cases (now 1.0 million) since 2 days ago — Bangladesh: +227 cases (now 1.6 million), +2 deaths (now 27980), +16891 tests (now 10.9 million) since a day ago | 14:36 |
| Brainstorm | New from The Indian Express (Health): Life-style: Merriam-Webster chooses ‘vaccine’ as the 2021 word of the year → https://indianexpress.com/article/lifestyle/life-style/merriam-webster-chooses-vaccine-as-the-2021-word-of-the-year-7647234/ | 14:39 |
| Brainstorm | New from COVID on Twitter: BNO Newsroom (@BNODesk): Scotland reports 6 cases of new coronavirus variant, including people with no travel history, indicating community transmission bnonews.com/index.php/2021… → https://twitter.com/BNODesk/status/1465319159441596424 | 15:08 |
| merpnderp | On that UK study of increased PULS scores post vaccination, how is it possible this hasn't been discovered before? Wouldn't this have been obvious to every cardiologist in the world? | 15:15 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Vaccine makers scramble to assess the Omicron Covid strain; Pfizer to step up Covid pill production → https://www.statnews.com/pharmalot/2021/11/29/covid19-vaccine-omicron-pfizer-merck-wto-moderna/ | 15:29 |
| Brainstorm | New from BBC Health: Omicron: How do you detect it?: Swabs from PCR tests can help identify omicron, depending on the lab they go to. → https://www.bbc.co.uk/news/health-59460252 | 15:39 |
| Brainstorm | New from Politico: Africa: WHO chief: Omicron backlash against Africa shows why world needs pandemic treaty → https://www.politico.eu/article/who-tedros-adhanom-gheybreyesus-coronavirus-omicron-backlash-africa-pandemic-treaty/ | 15:48 |
| Brainstorm | New from WHO Euro: New COVID-19 variant of concern named Omicron: On 26 November, WHO’s Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE) designated the B.1.1.529 variant (first reported by South Africa two days earlier) as a [... want %more?] → https://www.euro.who.int/en/health-topics/health-emergencies/pages/news/news/2021/11/new-covid-19-variant-of-concern-named-omicron | 16:08 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): All our #Omicron fastq files (i.e. raw sequencing data) available: NGS-SA SARS-CoV-2 Omicron Sequencing in South Africa - BioProject Accession: PRJNA784038 ncbi.nlm.nih.gov/sra/?term=PRJN… - All contigs at @GISAID but please respect our data and contact us if [... want %more?] → https://twitter.com/Tuliodna/status/1465338678264401934 | 16:18 |
| Guest23 | The Japanese government has begun to impose a total ban on foreigners | 16:22 |
| Guest23 | Russia and Pakistan cut off flights to Chinas HKSAR | 16:23 |
| Guest23 | All to prevent Omicron variant | 16:24 |
| darsie | Nationals can have omicron, too. | 16:25 |
| Guest23 | yes，ur right | 16:26 |
| darsie | ▯ | 16:26 |
| Guest23 | So they are just trying to find a better way to delay time | 16:27 |
| Guest23 | It is worth mentioning that Sweden does not seem to have cut off routes with southern Africa | 16:29 |
| Guest23 | So the Swedish people may bear the brunt | 16:31 |
| darsie | my font doesn't have ， U+FF0C FULLWIDTH COMMA. | 16:34 |
| Brainstorm | Updates for Canada: +1630 cases (now 1.8 million), +7 deaths (now 29689) since 23 hours ago — United Kingdom: +91 cases (now 10.2 million) since 21 hours ago | 16:47 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Sequencing #SARSCoV2 in the US has markedly improved in recent months, but it is still ranked #20 by per cent (3.6% of cases) and per cent ≠ key detection washingtonpost.com/world/2021/11/… @MiriamABerger Await US detection of Omicron this week pic.twitter.com/Nvxvk4dOIS → https://twitter.com/EricTopol/status/1465344842960015366 | 16:48 |
| Brainstorm | Updates for Netherlands: +21482 cases (now 2.7 million), +32 deaths (now 19798) since 23 hours ago | 17:30 |
| darsie | /mode #libera +b $a:betelgeuse$##fix_your_connection | 17:46 |
| Brainstorm | New from Reddit (test): Monday 29 November 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://old.reddit.com/r/CoronavirusUK/comments/r4z15k/monday_29_november_2021_update/ | 17:48 |
| Brainstorm | New from r/WorldNews: worldnews: 2.5 Million Nurses Demand UN Probe Into 'Covid-19 Criminals' Blocking Patent Waiver | The European Union, the United Kingdom, Switzerland, Norway, and Singapore "must be investigated for blocking a faster global vaccine rollout leading to the [... want %more?] → https://old.reddit.com/r/worldnews/comments/r4ztip/25_million_nurses_demand_un_probe_into_covid19/ | 17:58 |
| Brainstorm | New from COVID on Twitter: Trevor Bedford (@trvrb): We'll see as this unfolds, but I expect contributions of intrinsic transmissibility vs immune evasion to be distinguished via:1. neutralization assays2. variant-specific vaccine effectiveness3. modeling approaches along the lines of those above by @C_Althaus15/15 → https://twitter.com/trvrb/status/1465364325829283844 | 18:08 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Real-time detection of Covid ~3 days before symptom onset via wearable sensors nature.com/articles/s4159… @NatureMedicine @SnyderShot @Spakho @StanfordMed pic.twitter.com/VM3eWyBPb9 → https://twitter.com/EricTopol/status/1465366588245221376 | 18:18 |
| Raf[m] | <Brainstorm> "New from COVID on Twitter..." <- Link broken for anyone else? | 18:24 |
| Brainstorm | New from The Indian Express: World: ‘Told you so’: African countries feel brunt of West’s scattershot pandemic response → https://indianexpress.com/article/world/told-you-so-african-countries-feel-brunt-of-wests-scattershot-pandemic-response-7648029/ | 18:28 |
| Brainstorm | Updates for Italy: +7972 cases (now 5.0 million), +65 deaths (now 133739), +276000 tests (now 118.6 million) since a day ago | 18:39 |
| LjL | Raf[m]: the Nature link is broken because of the "..." (not under my control I'm afraid as something else grabs the content) but the Twitter link itself works | 18:45 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Such non-sense from the U.K. talking that the main problem is hesitancy in Africa. They had hoarded vaccines for 1 and 1/2 years and now want to blame in hesitancy? Why hesitancy in Africa? Because they do not trust the north and developed countries... Maybe a [... want %more?] → https://twitter.com/Tuliodna/status/1465376451964899329 | 18:56 |
| Raf[m] | <LjL> "Raf: the Nature link is broken..." <- Got it thanks | 18:58 |
| Raf[m] | https://www.nature.com/articles/s41591-021-01339-0 | 18:59 |
| Brainstorm | New from StatNews: ‘Not a cause for panic’: Biden urges calm in face of Omicron fears: President Biden said on Monday that the new Omicron coronavirus variant “is a cause for concern, not a cause for panic.” → https://www.statnews.com/2021/11/29/not-a-cause-for-panic-biden-urges-calm-in-face-of-omicron-fears/ | 19:06 |
| darsie | Buy toilet paper? | 19:07 |
| LjL | buydet | 19:13 |
| Brainstorm | New from Politico: Biden: Omicron ‘a cause for concern, not a cause for panic’: The president plans to take action against omicron 'not with shutdowns or lockdowns, but with more widespread vaccinations, boosters, testing and more.' → https://www.politico.com/news/2021/11/29/biden-omicron-523449 | 19:28 |
| Brainstorm | New from COVID on Twitter: Nussenzweig_LAB (@NussenzweigL): Will the Vaccines Stop Omicron? Scientists Are Racing to Find Out. nytimes.com/2021/11/28/hea… → https://twitter.com/NussenzweigL/status/1465387275295109135 | 19:38 |
| Brainstorm | Updates for United Kingdom: +42168 cases (now 10.2 million), +35 deaths (now 145253) since 16 hours ago — Canada: +1586 cases (now 1.8 million), +9 deaths (now 29691) since 22 hours ago | 19:41 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Our covid times :-)by @BillBramhall pic.twitter.com/5RMknn4zsk → https://twitter.com/EricTopol/status/1465390623494602756 | 19:47 |
| Brainstorm | Updates for Spain: +22911 cases (now 5.2 million), +53 deaths (now 88008) since 2 days ago | 20:06 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: AnGes: AG0301-COVID19 → https://covid19.trackvaccines.org/vaccines/3/ | 20:07 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: Aivita Biomedical Inc: AV-COVID-19 → https://covid19.trackvaccines.org/vaccines/74/ | 20:17 |
| Brainstorm | Updates for Sudan: +770 cases (now 42826), +27 deaths (now 3141) since 4 days ago — France: +268 cases (now 7.7 million), +4 deaths (now 119879) since 22 hours ago | 20:31 |
| Arsanerit | "Don't panic" | 20:38 |
| LjL | it's the hallmark signal for panicking | 20:40 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): I will not accept charted planes with reagents as the Travel ban is so damaging to our economy. There are more effective ways to avoid introductions of variants (such as pre-and post- arrival tests, vaccinations, self- or forced- isolation) than blanked travel [... want %more?] → https://twitter.com/Tuliodna/status/1465404310389497858 | 20:45 |
| Brainstorm | New from COVID on Twitter: Elina I. Zúñiga (@ZunigaLab): Hope you can join our next #globalimmuno talk by @GoldrathLab (same time, same link)Title: Transcriptional regulation of CD8 T cell responses to pathogens and tumors #TCELL @ImmunologyAAI @CytokineSociety @ASImmunology @FAISAfrica @EFIS_Immunology [... want %more?] → https://twitter.com/ZunigaLab/status/1465405650708492291 | 20:55 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Most infected are also young, but symptoms seem mild. Vaccines work.Take home message: it doesn't seem bad. Not good, okay, or better: we need to wait. newsweek.com/most-omicron-c… → https://twitter.com/Marc_Veld/status/1465410086596141068 | 21:05 |
| Brainstorm | New from CIDRAP: News Scan for Nov 29, 2021: COVID-19 and neurologic problems COVID reinfection less severe Novel H1 flu in Oklahoma CWD detected in Idaho deer Avian flu in Iran, Europe, China → https://www.cidrap.umn.edu/news-perspective/2021/11/news-scan-nov-29-2021 | 21:23 |
| Jigsy | Went the store earlier. | 22:05 |
| Jigsy | Hardly anyone wearing a mask. | 22:05 |
| zutt | that's no good :( | 22:06 |
| Jigsy | IKR? | 22:07 |
| Brainstorm | Updates for India: +4848 cases (now 34.6 million) since 22 hours ago | 22:29 |
| Brainstorm | New from COVID on Twitter: Covid Fact Check UK (@fact_covid): Top stuff as ever from @EdConwaySky, who doesn’t do sensationalism."No-one knows what's happening!" doesn't make for an especially compelling front page headline, which is part of the explanation for why there are so many hot takes around at the [... want %more?] → https://twitter.com/fact_covid/status/1465431885048389633 | 22:30 |
| Brainstorm | New from WebMD: Merck’s COVID-19 Pill May Be Less Effective Than First Hoped: According to an analysis by scientists at the FDA, the experimental pill cut the risk of hospitalization or death from COVID-19 by about 30% compared to a placebo. → https://www.webmd.com/lung/news/20211129/merck-covid-pill-less-effective | 22:58 |
| Brainstorm | New from r/WorldNews: worldnews: Documents Reveal Biden Admin Not Fighting for a Covid Vaccine Patent Waiver, Despite Public Statements | Amid mounting concern about the Omicron variant, Biden declared U.S. support for a Covid-19 vaccine patent waiver. But new documents from [... want %more?] → https://old.reddit.com/r/worldnews/comments/r56p5w/documents_reveal_biden_admin_not_fighting_for_a/ | 23:08 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: AnGes: AG0302-COVID19 → https://covid19.trackvaccines.org/vaccines/31/ | 23:17 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): People are asking why not 3rd shots for age <18, i.e. teens?There is no application yet from a vaccine manufacturer to FDA for age <18, so it can't be recommended yet. That will change soon...... → https://twitter.com/EricTopol/status/1465445789614833664 | 23:26 |
| Brainstorm | New from COVID on Twitter: Michael Lin, PhD-MD 🧬 (@michaelzlin): Well that's interesting. Pardes has a patent that apparently covers Pfizer's Paxlovid (PF-07321332). Notice the granted invention encompassing Paxlovid. We may see a big licensing deal or courtroom drama in the future. Interestingly, the patent [... want %more?] → https://twitter.com/michaelzlin/status/1465446964879835137 | 23:36 |
| Brainstorm | Updates for Greenland: +124 cases (now 1456), +3684 tests (now 110294) since 3 days ago | 23:37 |
| Brainstorm | New from COVID on Twitter: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Mask- N95+ or ffp2+ → https://twitter.com/fitterhappierAJ/status/1465451659316895748 | 23:55 |
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