libera/##covid-19/ Tuesday, 2021-12-14

BrainstormUpdates for Colombia: +2287 cases (now 5.1 million), +56 deaths (now 129163), +59043 tests (now 28.7 million) since 23 hours ago — French Guiana: +89 cases (now 46510), +1 deaths (now 333), +3736 tests (now 466594) since 3 days ago00:01
LjLStarting to have a few Omicron cases in Lombardy apparently00:15
LjLNot many, they're just now starting to trace them, but you know, they become many quickly00:15
lastshellIn Ontario 21% of the covid patients are omicron https://www.youtube.com/watch?v=RcPifKbIaKc00:16
LjLWow00:17
LjL%cases Ontario00:17
BrainstormLjL: Ontario, Canada has had 638905 confirmed cases (4.8% of all people) and 10122 deaths (1.6% of cases; 1 in 1329 people) as of a day ago. +1144 cases, +5 deaths since 23 hours ago. See https://offloop.net/covid19/?default=Ontario&legacy=no00:17
LjLAny clue if the plan (assuming there's one) is still to decommission the Google/Apple exposure notification system at the end of 2021? It's kinda weird no one is talking about it00:19
lastshellmost of the experts says they can not control omicron spreed with vaccines00:23
LjLWell you couldn't really control the *spread* of Delta either00:26
LjLunless by "control" you mean "manage to keep going even though there's still a lot of spread" like the UK did00:26
LjLI think we're all clear that the current vaccines don't stop infections. With Delta they could reduce infections, not sure if they will do that with Omicron too if everyone gets a booster, but it's clear it's not enough to suppress it00:28
BrainstormNew from Johnson&Johnson: Innovation: New Data from MajesTEC-1 Study Show Continued Deep and Durable Responses of Teclistamab (BCMAxCD3 Bispecific Antibody) in Treatment of [... want %more?] → https://www.jnj.com/new-data-from-majestec-1-study-show-continued-deep-and-durable-responses-of-teclistamab-bcmaxcd3-bispecific-antibody-in-treatment-of-heavily-pretreated-patients-with-multiple-myeloma00:29
BrainstormUpdates for San Marino: +136 cases (now 6600) since 3 days ago — Paraguay: +73 cases (now 463828), +8 deaths (now 16513) since 23 hours ago00:32
de-factowithout contacts there is no transmission, hence reducing contact rate will prevent any spread00:35
de-factoif Omicron is much more reproductive we would need much more contact reduction to compensate for those carriers that do spread to many susceptible00:36
BrainstormNew from Ars Technica: Science: 9 Minnesota hospital systems plead for people to take COVID seriously → https://arstechnica.com/00:48
BrainstormNew from r/COVID19: COVID19: Mutations in RBD of SARS-CoV-2 Omicron variant result stronger binding to human ACE2 protein → https://www.reddit.com/r/COVID19/comments/rftrj1/mutations_in_rbd_of_sarscov2_omicron_variant/01:07
BrainstormUpdates for Switzerland: +30 deaths (now 11841) since 10 hours ago01:10
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): • Denmark expects Omicron to overtake Delta this week• 10k daily cases expected this week, 2.5x higher than 2020 peak• Concern that hospitals will be impacted, as Omicron can still cause severe disease even if less commonly• Boosters will be [... want %more?] → https://twitter.com/michaelzlin/status/147054488068635443501:16
LjL<Brainstorm> New from r/WorldNews: worldnews: Norway bans serving alcohol in bid to curb Omicron surge → https://www.reddit.com/r/worldnews/comments/rftth4/norway_bans_serving_alcohol_in_bid_to_curb/01:24
BrainstormUpdates for Australia: +1984 cases (now 232746), +7 deaths (now 2113) since 22 hours ago — Rwanda: +79 cases (now 100713), +14184 tests (now 3.7 million) since a day ago01:35
BrainstormNew from r/WorldNews: worldnews: Omicron’s Spread Across Hotel Hall Highlights Transmission Worry → https://old.reddit.com/r/worldnews/comments/rfub7v/omicrons_spread_across_hotel_hall_highlights/01:35
LjL"Closed-circuit television camera footage showed neither person left their room nor had any contact, leaving airborne transmission when respective doors were opened for food collection or Covid testing the most probable mode of spread"01:39
de-facto.title https://www.covid19genomics.dk/statistics <-- no Omicron yet as its 2 weeks behind, something to watch for updates01:41
Brainstormde-facto: From www.covid19genomics.dk: Danish Covid-19 Genome Consortium01:41
de-facto.title https://www.sst.dk/en/english/corona-eng/status-of-the-epidemic/covid-19-updates-statistics-and-charts <-- also this of course01:42
Brainstormde-facto: From www.sst.dk: COVID-19 surveillance - Danish Health Authority01:42
de-facto.title https://arxiv.org/abs/2110.0053301:44
Brainstormde-facto: From arxiv.org: [2110.00533] Relative Contagiousness of Emerging Virus Variants: An Analysis of SARS-CoV-2 Alpha and Delta Variants01:44
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): With so much new data, I've just posted an updated summary for where we stand with Omicron. erictopol.substack.com/p/omicron-is-g… @SubstackInc  It's called "Ground Truths". It's free to subscribe. It's a 1-month experiment that I'm trying to get deeper into [... want %more?] → https://twitter.com/EricTopol/status/147055299471012659601:44
de-facto.title https://erictopol.substack.com/p/omicron-is-getting-more-defined?justPublished=true01:49
Brainstormde-facto: From erictopol.substack.com: Omicron is getting more defined - by Eric Topol01:49
de-facto.title https://www.biorxiv.org/content/10.1101/2021.12.12.472252v101:54
Brainstormde-facto: From www.biorxiv.org: Improved neutralization of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech BNT162b2 COVID-19 vaccine boosting | bioRxiv01:54
LjLi wrote a *controvurshal* (at least i assume) post: https://np.reddit.com/r/worldnews/comments/rfub7v/omicrons_spread_across_hotel_hall_highlights/hog8rli/01:55
LjLde-facto, he's on substack? interesting, i saw that site initially only from links of people who were clearly conspiracy theorist and nutters01:55
de-factoi think he just joined as he announced that on twitter01:58
LjLoh01:59
LjLwell maybe there is being some effort to "rebalance" the content of that side because maybe it's becoming too important?01:59
LjLi went through a couple of links to it from a subreddit that was *clearly* anti-vax and stuff01:59
de-facto"We utilized an authentic virus, multicycle neutralisation assay to demonstrate that sera collected 1, 3, and 6 months post-two doses of Pfizer-BioNTech BNT162b2 has a limited ability to neutralise SARS-CoV-2. However, four weeks after a third dose, neutralizing antibody titres are boosted."01:59
LjLi quickly got the impression those substacks only ever linked to each other as "sources"01:59
de-facto"Despite this increase, neutralising antibody titres are reduced 4-fold for Omicron compared to lineage A.2.2 SARS-CoV-2."01:59
de-factointeresting so booster needs some time to mature?02:00
LjLwhat are you quoting from?02:00
de-factothe biorxiv link02:02
de-facto"there was a 4-fold reduction in median nAbT against Omicron in contrast to the wild-type and 1.5-fold decrease of nAbT against Delta VOC following the third dose."02:02
de-factojust half an hour old info :P02:03
LjLwell it's compatible with what i'd heard though?02:03
LjLlike 75% estimated efficacy (from neutralization, not real-world data) against Omicron with a booster02:03
LjLdown to >90% against Delta02:03
LjLthat's compatible with a 4-fold reduction in how much of the thing the antibodies do, isn't it?02:04
LjLnot sure if they simply looked at 4 weeks after, or they actually had to wait 4 weeks for a peak02:04
LjL4 weeks seems long to me, i remember something stating 1 week after the booster you already had antibodies peaking, faster than the first shots (understandably so)02:04
de-factoyeah but maybe they need some time to mature, e.g. hypermutate?02:05
antepost[m]just keep in mind biorxiv is not scientific .... its just prerelease02:05
de-factoyes its a very early preprint, not peer reviewed02:06
de-factobut its scientific, just not finalized, work in progress02:06
de-factoi think we really need to understand if T-cell induced immunity will hold against Omicron02:07
de-factoat least against severe progressions02:07
LjL"not scientific"?02:10
LjLlack of peer review doesn't make science not scientific02:10
LjLand peer review is often not very scientific itself02:10
LjLit's two random folks with a science degree, going over a paper, unpaid02:10
de-factoalso another interesting read by Eric Topol02:18
de-facto.title https://erictopol.substack.com/p/is-omicron-ominous02:18
Brainstormde-facto: From erictopol.substack.com: Is Omicron Ominous? - by Eric Topol - Ground Truths02:18
de-facto.title https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1040076/Technical_Briefing_31.pdf02:31
Brainstormde-facto: From assets.publishing.service.gov.uk: SARS-CoV-2 variants of concern and variants under investigation (UKHSA)02:31
de-facto.title https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-of-concern-variant-risk-assessments02:32
Brainstormde-facto: From www.gov.uk: Investigation of SARS-CoV-2 variants of concern: variant risk assessments - GOV.UK02:32
LjLshould we call it Omicrous?02:34
de-factotheir risk assessment shows too many red lights for my taste02:35
LjLde-facto, i somehow suspect that the UK government's escalation of measures is partly due to that paper you linked the other day, i forget which university, but anyway with the modelling for Omicron in the UK02:36
de-factoyes of course otherwise having them model the scenario would not make much sense if the results were irrelevant02:38
de-facto.title https://cmmid.github.io/topics/covid19/omicron-england.html <-- this here from https://www.lshtm.ac.uk/newsevents/news/2021/modelling-potential-impact-omicron-england ?02:39
Brainstormde-facto: From cmmid.github.io: Modelling the potential consequences of the Omicron SARS-CoV-2 variant in England | CMMID Repository02:39
de-facto.title https://www.gov.uk/government/publications/sage-98-minutes-coronavirus-covid-19-response-7-december-2021/sage-98-minutes-coronavirus-covid-19-response-7-december-2021 <-- or that?02:39
Brainstormde-facto: From www.gov.uk: SAGE 98 minutes: Coronavirus (COVID-19) response, 7 December 2021 - GOV.UK02:39
de-facto.title https://files.ssi.dk/covid19/omikron/statusrapport/rapport-omikronvarianten-09122021-ke43 <-- Report about Omicron in Denmark from last week (in Danish)02:42
Brainstormde-facto: From files.ssi.dk: Rapport om omikronvarianten02:42
LjLde-facto, yes that02:43
de-facto.title https://covid19.ssi.dk/virusvarianter02:45
Brainstormde-facto: From covid19.ssi.dk: Virusvarianter02:45
de-facto.title https://files.ssi.dk/covid19/omikron/statusrapport/rapport-omikronvarianten-13122021-i30w from https://covid19.ssi.dk/virusvarianter/omikron02:55
Brainstormde-facto: From files.ssi.dk: Rapport om omikronvarianten02:55
de-factoreport about Omicron in Denmark from today02:55
LjL<de-facto> yes of course otherwise having them model the scenario would not make much sense if the results were irrelevant ← if only governments *never* ignored good science... but sometimes they do03:02
LjLsometimes one only does science in the *hope* it will be paid attention to03:02
de-factoDenmark 09-12-2021:  6,552 SARS-CoV-2 with 666 Omicron being 10.2 %03:15
de-factoi just took their absolute number of cases in Denmark and made a nonlinear fit03:15
de-facto.title https://imgur.com/a/aQgNY4H https://i.imgur.com/HRBe7Mb.png Omicron(t) = Omicron(t0) * Rt ^(t/4) = 4.5 * 3.4^(t/4)  src: https://covid19.ssi.dk/virusvarianter/omikron with https://files.ssi.dk/covid19/omikron/statusrapport/rapport-omikronvarianten-13122021-i30w03:15
Brainstormde-facto: From imgur.com: COVID Denmark: OMICRON (B.1.1.529) cases - Album on Imgur03:15
antepost[m]https://scholarlykitchen.sspnet.org/2018/03/14/preprints-citations-non-peer-reviewed-material-included-article-references/03:16
de-factogrrr made a typo03:16
de-factook correction03:20
de-facto.title https://imgur.com/a/AMqZV7j https://i.imgur.com/LhtD3Gs.png "COVID Denmark: OMICRON (B.1.1.529) cases" Omicron(t) = Omicron(t0) * Rt ^(t/4) = 4.5 * 3.4^(t/4) src: https://covid19.ssi.dk/virusvarianter/omikron with https://files.ssi.dk/covid19/omikron/statusrapport/rapport-omikronvarianten-13122021-i30w03:20
Brainstormde-facto: From imgur.com: COVID Denmark: OMICRON (B.1.1.529) cases - Album on Imgur03:20
-RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Improved neutralization of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech BNT162b2 COVID-19 vaccine boosting ( https://www.zotero.org/groups/covid_links/items/BV6I4I3T )03:20
LjLantepost[m], i'm not sure if you realize that there's like a COVID study published every minute (eyeballing, could be more or could be less, but i do remember reading about a mindboggling number being published), and preprints that we discussed here in 2020 are sometimes only passing peer-review *now*... not because they were bad studies, but because there's a huge backlog to peer review and publish papers03:22
LjLyou can understand that information about some 2020 variant may not even be very relevant anymore today03:23
LjLso yes, preprints are unavoidable when "doing COVID science"03:23
LjLthe article you posted is from 2018. you may have noticed that 2021 is markedly different from 2018.03:23
LjLand even then, it says "The tide seems to be flowing toward more inclusion [of preprints] in reference lists."03:24
de-factoso if that would continue like that in Denmark Omicron(t) = Omicron(t0) * Rt ^(t/4) = 4.5 * 3.4^(t/4) hence Rt(4d) ~ 3.4 we would have *doubled* the number of cases each T2 = 4d Ln(2) / Ln(3,4) ~ 2.3 days03:24
de-factothats ... a bit crazy03:24
antepost[m]what has the date to do with the principle of science ?? ... even if the site is vrom 1722 it does not change the fact that preprints can be a personal opinion and even if they look scientific in theyr document structure they are not valid science in the first place03:26
LjLantepost[m], it has everything to do with it, since peer review wasn't even *common* until a few decades ago03:26
LjLthe site couldn't have been from 1722 because peer review didn't "exist"03:27
LjLit's not a "principle of science", it's a current principle of the scientific publishing industry03:27
LjLclaiming otherwise is ludicruous03:27
antepost[m]so peer review exists since before the bat virus from wuhan03:27
LjLyes, it does03:29
LjLi'm glad the goalpost has moved from "1722" to "sometime before the virus"03:29
LjLanyway here is what a medical doctor had to go through for a peer review process https://youtu.be/WHC1bY_qdQ0?t=92603:29
LjLand here are some of his opinion on the medical publishing industry in general https://www.youtube.com/watch?v=PriwCi6SzLo&t=22s03:30
LjLand here are a large amount of study papers, most of which preprints https://www.zotero.org/groups/4391070/covid_links/library03:30
LjLi think you'll have to deal with it03:30
LjLof course that doesn't mean every preprint is not bollocks. but not every peer-reviewed paper is not bollocks, either03:31
antepost[m]LjL: https://en.wikipedia.org/wiki/Scholarly_peer_review03:31
antepost[m]> The first record of an editorial pre-publication peer-review is from 1665 by Henry Oldenburg, the founding editor of Philosophical Transactions of the Royal Society at the Royal Society of London.[12][13][14]03:31
antepost[m]> The first peer-reviewed publication might have been the Medical Essays and Observations published by the Royal Society of Edinburgh in 1731. The present-day peer-review system evolved from this 18th-century process,[15] began to involve external reviewers in the mid-19th-century,[16] and did not become commonplace until the mid-20th-century.[17]03:31
antepost[m]ok it was 10 years later .. so what03:31
LjLhere is a publication that tries to collect all the (often peer-reviewed) papers that had to be retracted, either because of errors or because of conflicts of interest or misrepresentations https://retractionwatch.com/03:31
LjLyou must have skimmed over the "did not become commonplace until the mid-20th-century.[17]"03:32
LjLall the things that were published and NOT peer reviewed between 1665 and the "mid 20th century" are STILL SCIENCE03:32
LjLthat includes a bunch of things published by Einstein, for example03:32
LjLjust stop claiming something needs to be peer-reviewed "to be science", because that's not true. period.03:32
BrainstormUpdates for Sint Maarten: +21 cases (now 4653) since a day ago — Bermuda: +20 cases (now 5784), +6762 tests (now 666941) since 3 days ago — Antigua and Barb.: +13 cases (now 4175) since a day ago03:33
antepost[m]it looks like science and it can be science as any personal view can be science ... how ever its not valid to use in science03:34
LjLno. you're wrong.03:35
LjLeven the article you cited claims you're wrong.03:35
LjLso just stop.03:35
LjLthis channel is not for advocating against valid science being science.03:36
LjLpreprints don't just "look like science"03:36
LjLthat is a depiction that makes them look like they're faking it03:36
LjLwhich is absolutely not the wrong track03:36
LjLthe right* track03:36
antepost[m]even science journals have theyr rules and not in favour of personal opinions03:37
LjLand even this channel has its rule and not in favor of *your* personal opinion that you can't even substantiate with the articles you post (which, in fact, point in the opposite direction)03:37
LjLdrop it.03:37
LjLif you have specific criticism on a preprints' specific contents, be our guest. but don't just dump *all* preprints into a "not science" bin, not here.03:38
antepost[m]LjL: there is no peer review ... you dont know if they fake it or not ... if one uses his own postulate as an evidence for his other postulate it can be written scientific but its not valid science03:38
LjL-Matrix.¡𝖠𝗇𝗍𝖾𝗉𝗈𝗌𝗍¡.: I recommend you read the links posted during this conversation, both mine *and yours*, and then if your ideas are clearer on the matter, send me a DM. For now you're muted from the room. I think I've been clear about asking you to drop it.03:39
LjLde-facto, i just tried the German CovPass app... it took a while to scan my QR, maybe not enough light, and the QR is very dense, but eventually it got it, but the QR *it* displays is actually a much simpler QR03:47
LjLdo you know if they have a "simplified" version of the certificate now in Germany?03:48
LjLi know they do in Switzerland, but the app notes it's *only valid in Switzerland*03:48
LjLso it still also shows the original, big certificate03:48
LjLmy original certificate is "4x4" of those alignment markers that QR codes hae03:49
LjLbut the CovPass QR is only 3x303:49
de-factoi think the redundancy in QR codes is choose-able03:50
de-factothe ones they gave me seems to be 2x2 the app makes 3x3 out of it03:53
LjLyet the CovPass app FAQ themselves show a printout that's identical to the printout i have, with a 4x4 code...03:53
LjLuhm03:53
de-factoso maybe the italian printout adds even more redundancy e.g. 4x4?03:53
LjLi was only given 2x2 certificates that are local certificates and are *not* EU passes03:53
LjLde-facto: look, this is the example printout certificate in the German FAQ03:54
LjLhttps://www.digitaler-impfnachweis-app.de/assets/img/eu_covid_19_certificate_056e16d084.png03:54
LjLIt's 4x4 and looks the same as my physical green pass03:54
LjLanyway, the Swiss app does recognize my "simplified" German certificate03:55
LjLnot sure about the Italian app since it's not in F-Droid :P03:55
de-factoyeah mine looks different03:55
de-factothe encoded info should be the same, but QR adds redundancy afaik03:56
de-factolike error correction codes or such03:56
LjLi don't know, the 4x4 one is very hard to scan. it may have more error correction but it also makes it much harder to scan it correctly ;(03:57
LjLi guess i'm wondering if the EU certificate system is slowly trying to move to a 3x3 setup03:58
de-factohttps://en.wikipedia.org/wiki/QR_code#Error_correction03:58
LjLthe Swiss app doesn't let me generate what they call a "Certificate Light". maybe it sees it's not a Swiss citizen03:58
LjLthat seems to be saying that the error correction amount is fixed to 15 symbols at most, and that's within one "box"03:59
de-facto"QR codes use Reed–Solomon error correction" with different levels of redundancy03:59
LjLhmm03:59
de-factoif you want to debug it, scan both and compare the string04:00
de-factoi bet its the same for the small and the big QR code04:00
LjLi guess i may half-heartedly install the Italian verification app to see if it sees my "German" code as valid04:00
LjL*if* it works, it should be better than the 4x4 code just becaue 4x4 is *so* dense04:00
de-factothen print it out and draw on each, until they would not scan correctly anymore04:01
de-factoi bet the denser one with more error correction would survive that better, well until there is a resolution limit or such04:01
BrainstormNew from Politico: Boris Johnson: down but not out: British politics' comeback kid faces a rebellion over COVID rules, a bruising by-election, and muttering about a leadership challenge. → https://www.politico.eu/article/boris-johnson-christmas-party-investigation-uk-covid/04:02
LjLhmm to be fair my new phone even reads the *tiiiiiny* 4x4 certificate that the Swiss app shows before you actually click on it and make it larger. so i guess only printed certificates are so hard to read :P04:03
LjLi guess an AMOLED screen has a lot more contrast than a sheet of paper under bad lighting...04:03
LjLbut yeah, the Italian verification app does recognize the German certificate04:03
de-factoyeah it should as they all use the EU system, dont they?04:04
LjLyes, but i had never seen a smaller than 4x4 certificate before, except this "swiss certificate light" thing - and that one said it would *not* work out of Switzerland04:05
de-factothe cost for more redundancy is having a denser QR and that is less well scanable from further distance04:06
LjLde-facto, not just from further distance, i tried from pretty close...04:08
LjLand yes i think 4x4 is just too large04:09
LjLthe redundancy advantage is completely swamped by how hard it is to scan04:09
LjLthese checks need to be done quickly04:09
LjLby the way, it's also completely preposterous that the Immuni app (one of the two italian apps that let you display a green pass, the other being Io, which needs your e-ID login to show it) doesn't just let me scan a printed QR and add it to my "wallet"... the German and Swiss apps easily do that04:10
LjLinstead it asks me for my "authcode" (which is sent via SMS, hopefully i never lose that SMS...), my healthcare card number... it's quite a lot more complicated than just scanning a QR code :\04:10
BrainstormUpdates for British Virgin Islands: +26 cases (now 2842), +1 deaths (now 39) since 7 days ago04:10
de-factoyeah there definitely is an optimum point for each scenario04:11
BrainstormNew from r/COVID19: COVID19: Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients → https://www.reddit.com/r/COVID19/comments/rfxm8o/efficacy_and_safety_of_covid19_convalescent/04:31
BrainstormUpdates for Bolivia: +1891 cases (now 554999), +13 deaths (now 19330) since a day ago04:35
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): In this column, I present a conceptual model to help explain the apparent reduced severity of Omicron-induced illness to date, emphasizing the T cell layer of defense pic.twitter.com/YWaG8RrgwU → https://twitter.com/EricTopol/status/147060083143503872004:50
minthosthis is pretty cool, I'm sure many of you have seen the corsi-rosenthal box already https://www.youtube.com/watch?v=H2YELPNsImk04:52
de-factoaaaw :)04:56
BrainstormUpdates for Belgium: +29421 cases (now 2.0 million), +127 deaths (now 27631), +225565 tests (now 26.0 million) since 2 days ago05:00
BrainstormUpdates for Germany: +35423 cases (now 6.6 million) since 23 hours ago — India: +5784 cases (now 34.7 million), +252 deaths (now 475888) since 23 hours ago05:37
BrainstormNew from Retraction Watch: Paper claiming a lack of evidence COVID-19 lockdowns work is retracted: This is an evolving story, and we will update as we learn more. A paper in Springer Nature’s Scientific Reports claiming there was essentially no evidence that [... want %more?] → https://retractionwatch.com/2021/12/13/paper-claiming-a-lack-of-evidence-covid-19-lockdowns-work-is-retracted/06:05
BrainstormNew from r/WorldNews: worldnews: Guatemalan president stands with ally Taiwan, derides Chinese vaccines | Taiwan News | 2021-06-03 12:02:00 → https://old.reddit.com/r/worldnews/comments/rfzqrl/guatemalan_president_stands_with_ally_taiwan/06:14
BrainstormUpdates for Illinois, United States: +19515 cases (now 1.9 million), +105 deaths (now 29339) since 2 days ago — New York, United States: +13503 cases (now 2.9 million), +54 deaths (now 58222) since a day ago — Massachusetts, United States: +11672 cases (now 981261), +29 deaths (now 19663) since 3 days ago [... want %more?]06:40
mrdatahttps://www.usatoday.com/story/news/health/2021/12/13/pennsylvania-man-treated-covid-ivermectin-dies/6498445001/07:04
mrdata"Man whose wife won a lawsuit to treat his COVID-19 with ivermectin has died"07:04
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The rapidity with which Omicron is taking hold in Europe "In Norway, health authorities warned that if no countermeasures were taken Omicron could infect up to 300,000 people a day compared with the previous peak of about 1,000 cases."ft.com/content/3c27c1… [... want %more?] → https://twitter.com/EricTopol/status/147063487579956838507:11
BrainstormUpdates for United Kingdom: +54578 cases (now 10.9 million) since 14 hours ago — Netherlands: +48 cases (now 2.9 million) since 13 hours ago07:29
sdfgsdfgdaaaamn look at UK07:38
BrainstormNew from MedicineNet: (news): British Studies Show Vaccines Weaken Against Omicron, But Boosters Help → http://www.medicinenet.com/script/main/art.asp07:58
BrainstormNew from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Zostavax, shingles (herpes zoster) vaccine (live), Herpes Zoster;Immunization, Date of authorisation: 19/05/2006, Revision: 31, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/zostavax08:45
Dredd<sdfgsdfg> "daaaamn look at UK..." <- What's up with it?08:53
Dredd<mrdata> "https://www.usatoday.com/story/..." <- The problem with ivermectin is you would need impossibly high doses (that would be toxic to us) to get the therapeutic effect08:54
minthosI wish those alternative cure people would promote fun drugs like LSD instead08:57
BrainstormNew from r/Coronavirus: Daily Discussion Thread | December 14, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/rg2l3r/daily_discussion_thread_december_14_2021/09:05
sdfgsdfgDredd it looks like omicron cases are starting to show up in the wave09:19
DreddCan you link me to where you can see it?09:19
sdfgsdfgmaybe after lunch09:20
Dreddk09:20
BrainstormUpdates for Tripura, India: +20 cases (now 84934) since a day ago — Arunachal Pradesh, India: +7 cases (now 55313) since a day ago — Germany: +35424 cases (now 6.6 million) since 16 hours ago09:34
BrainstormNew from r/WorldNews: worldnews: China detects first case of Omicron coronavirus variant on the mainland → https://old.reddit.com/r/worldnews/comments/rg2qtm/china_detects_first_case_of_omicron_coronavirus/09:42
ZdrytchX.cases australia09:52
BrainstormZdrytchX: Australia has had 232766 confirmed cases (0.9% of all people) and 2113 deaths (0.9% of cases; 1 in 12143 people) as of 2 hours ago. 50.4 million tests were done (0.5% positive). 20.2 million were vaccinated (78.8%). +20 cases since 5 hours ago. See https://offloop.net/covid19/?default=Australia&legacy=no09:52
BrainstormZdrytchX: If you know of an official or otherwise good site for data about Australia, with a reasonably short URL, please %tell LjL about it.09:52
ZdrytchX.cases victoria09:54
BrainstormZdrytchX: Victoria, Australia has had 138409 confirmed cases (2.1% of all people) and 1424 deaths (1.0% of cases; 1 in 4631 people) as of 3 hours ago. +1182 cases, +6 deaths since a day ago. See https://offloop.net/covid19/?default=Victoria&legacy=no09:54
BrainstormZdrytchX: If you know of an official or otherwise good site for data about Victoria, with a reasonably short URL, please %tell LjL about it.09:54
Guest47Hi folks, what do you make of this https://ibb.co/zFL9xz309:57
Guest47Can you see a line on the T side?09:57
Guest47I'll try to take a better pic, my phone is rubbish09:58
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): High quality pre-print:B.1.1.529 escapes majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes“data suggest Omicron could cause significant humoral immune evasion while NAbs targeting the sarbecovirus conserved region remain most [... want %more?] → https://twitter.com/GANyborg/status/147067809210868531410:01
Guest47https://ibb.co/qdvsjzb this is a bit better10:02
Guest47dtal ^^^10:02
xxGuest47: you're here often enough, why don't you get a registered nickname, or use a real irc client? Not forcing you, just curious.10:03
Guest47anonymity, privacy10:04
xxGuest47: you realize that what you're doing *now* is revealing your home IP to everyone?10:04
Guest47not a problem, thousands are using this IP10:05
xxstill weakens the privacy argument10:06
xxanyway, thanks for answering10:06
Guest47so what do you make of that shadow?10:06
xxdoes anyone have a study or report that would deal with the chinese numbers - an analysis whether the reports over the whole last year can be trusted?10:06
xxbecause the chinese numbers just feel weird, but I don't want to jump straight on the bandwagon that "china is lying about everything"10:07
BrainstormNew from COVID on Twitter: James Ward (@JamesWard73): Another week, another long thread on omicron.  This time, I’m still concerned, but perhaps a bit less worried than I was – mainly because I’m starting to be more confident that our experience of omicron will be significantly milder than earlier covid [... want %more?] → https://twitter.com/JamesWard73/status/147068095364331930510:21
minthosGuest47: looks clear to me10:28
Guest47minthos clear as in positive?10:29
minthosclear as in negative10:29
Guest47ah10:30
minthosthe control is red the test is white10:30
Guest47I've checked it at exactly 30m10:30
Guest47well there's like a grey shadow over the T line10:30
Guest47yesterday it was a very faint pink line10:31
Guest47and two days ago it was a dark red line10:31
minthosI'm no expert but I guess that means your viral load is very low and you're not infectious anymore10:32
Guest47I was gonna break self isolation today but ill wait another 24 hours10:32
BrainstormUpdates for Estonia: +618 cases (now 229214), +3 deaths (now 1868), +6512 tests (now 2.4 million) since a day ago10:42
BrainstormNew from r/WorldNews: worldnews: Major South African study concludes omicron variant more resistant to vaccines but causes less severe version of covid → https://old.reddit.com/r/worldnews/comments/rg3wnm/major_south_african_study_concludes_omicron/10:50
sdfgsdfgI don't understand how omicron "replaces" delta instead of adding to existing delta cases. Eric Topol's chart shows it's 100% replaced https://twitter.com/EricTopol/status/1470634875799568385?s=2010:55
sdfgsdfgwhoa, didn't even notice the potential number of 300,000 daily in Norway - I was only after the delta-omi displacement of SA10:57
sdfgsdfg.title10:57
Brainstormsdfgsdfg: From twitter.com: Eric Topol (@EricTopol): "The rapidity with which Omicron is taking hold in Europe "In Norway, health authorities warned that if no countermeasures were taken Omicron could infect up to 300,000 people [...]10:57
xxwe'd probably be in a good place if *everyone* got infected with omicron and gained natural immunity for a couple months out of it10:58
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Omicron advance predicted to be very fast.ft.com/content/3c27c1… pic.twitter.com/yI60whvmuY → https://twitter.com/Marc_Veld/status/147069331264230195510:59
minthospure speculation here: maybe the body's response to omicron is to produce a bunch of T-cells that also take out other variants so only omicron remains in the body, combined with omicron cases growing so rapidly that other cases become a vanishingly small proportion of total cases even if the number of other cases doesn't decrease faster than before11:00
minthosand people get infected with omicron and self-isolate/build immunity before they get the chance to catch other variants11:01
minthoslet's say you're in a room with 1 omicron and 1 delta person - you get both in your nose but the delta load isn't big enough to cause infection but the omicron load is, so you get omicron and not delta11:02
BrainstormNew from Reddit (test): CoronaVirus_ITALIA: In emergenza fino al 31 marzo: il governo vara la proroga (e complica Draghi al Colle) → https://old.reddit.com/r/CoronaVirus_ITALIA/comments/rg478z/in_emergenza_fino_al_31_marzo_il_governo_vara_la/11:18
BrainstormNew from BMJ: Gatekeepers, wizards, and a mutual appreciation of each other’s kingdoms: Collaborative working is crucial to providing joined up, high quality care, yet medicine continues to be a divided profession of gatekeepers (GPs) and wizards (specialists).12 The covid-19 pandemic... → http://www.bmj.com/content/375/bmj.n3005.short11:38
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): BREAKING ⬇️ Thread with important early data on vaccine efficacy re Omicron twitter.com/miamalan/statu… → https://twitter.com/GANyborg/status/147070694524625306011:58
BrainstormNew from ECDC: ECDC: Data on the daily number of new reported COVID-19 cases and deaths by EU/EEA country → https://www.ecdc.europa.eu/en/publications-data/data-daily-new-cases-covid-19-eueea-country12:07
sdfgsdfgcould it be that the real pandemic is just beginning and 2022 is going to be an entire fkfest12:31
minthoslooks that way12:31
minthos2020-2021 was just a rehearsal12:32
minthos(we failed)12:32
minthosI'm seriously considering crafting myself a papr before everyone panics12:34
BrainstormUpdates for Latvia: +930 cases (now 263145), +14 deaths (now 4390), +11911 tests (now 5.5 million) since a day ago — France: +11465 cases (now 8.4 million), +223 deaths (now 121647) since 15 hours ago12:34
BrainstormUpdates for Zambia: +471 cases (now 211705), +1 deaths (now 3671), +6706 tests (now 2.8 million) since a day ago13:05
sdfgsdfg.cases nsw13:13
Brainstormsdfgsdfg: New Brunswick, Canada has had 9704 confirmed cases (1.3% of all people) and 142 deaths (1.5% of cases; 1 in 5261 people) as of 6 hours ago. +100 cases, +2 deaths since a day ago. See https://offloop.net/covid19/?default=New%20Brunswick&legacy=no13:13
Brainstormsdfgsdfg: If you know of an official or otherwise good site for data about New Brunswick, with a reasonably short URL, please %tell LjL about it.13:13
sdfgsdfg.cases new south wales13:13
Brainstormsdfgsdfg: New South Wales, Australia has had 87248 confirmed cases (1.1% of all people) and 640 deaths (0.7% of cases; 1 in 12640 people) as of 6 hours ago. 141777 tests were done (61.5% positive). +795 cases, +1 deaths since a day ago. See https://offloop.net/covid19/?default=New%20South%20Wales&legacy=no13:13
Brainstormsdfgsdfg: If you know of an official or otherwise good site for data about New South Wales, with a reasonably short URL, please %tell LjL about it.13:13
BrainstormNew from Politico: Norway bans serving of alcohol as it tries to slow Omicron outbreak: 'For many this will feel like a lockdown, if not of society then of their lives and of their livelihoods,' says prime minister. → https://www.politico.eu/article/norway-prohibit-alcohol-serving-halt-omicron-outbreak/13:34
BrainstormUpdates for Nepal: +229 cases (now 824764), +2 deaths (now 11559), +9392 tests (now 4.7 million) since a day ago13:36
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 14DEC21 → https://old.reddit.com/r/nCoV/comments/rg6nk8/global_covid_cases_for_14dec21/13:43
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Good news regarding Pfizers anti-COVID-19 drug.Important to have at least a few more against different enzymes/mechanisms of action, and ideally use them together.statnews.com/2021/12/14/pfi… → https://twitter.com/Marc_Veld/status/147073754520195892413:53
minthoshttps://twitter.com/EricTopol/status/147072148030446387214:02
BrainstormNew from COVID on Twitter: John Burn-Murdoch (@jburnmurdoch): Another magnificent Omicron thread from James, evaluating the evidence to date and setting out a range of plausible scenarios for what happens next twitter.com/JamesWard73/st… → https://twitter.com/jburnmurdoch/status/147073863886244249914:02
minthoshttps://twitter.com/EricTopol/status/147073578774229401814:03
minthoshttps://twitter.com/EricTopol/status/147073946091653939514:03
minthosEric Topol14:03
minthos@EricTopol14:03
minthos·14:03
minthos21m14:03
minthosWe now have a safe and highly effective anti-Covid pill strategy (combination of nirmatrelvir (Paxlovid) and low dose ritnoavir to add to our defense vs Omicron14:03
minthossorry about the exceesive newlines14:04
minthosit seems it doesn't do much good for vaccinated people though14:10
Justin[m]1Where does it say it doesn't offer benefits to vaccinated people?14:20
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Graph of Pfizer 3rd shot (booster) vs Omicron symptomatic infection, restoring to 75% protection, significantly less compared to its effect vs Delta (95%) with 95% CI, @UKHSA data, vs unvaccinatedft.com/content/8a6a0e…by @hannahkuchler @donatopmancini [... want %more?] → https://twitter.com/EricTopol/status/147074471739872051314:22
minthosoh, hmm.. maybe I invented that myself. I can't seem to find it now.14:24
minthosPfizer also reported results from a second study in adults with Covid at normal risk of developing severe disease, a group that included vaccinated people. That study failed to meet its main goal, of increasing the sustained alleviation of self-reported symptoms, at an interim analysis; the study is continuing. But Pfizer said that there was a decrease in hospitalization in that group, too, although14:26
minthosnumbers were small.14:26
minthosfrom here https://www.statnews.com/2021/12/14/pfizers-covid-pill-remains-89-effective-in-final-analysis-company-says/14:27
minthosThe study of patients who were at lower risk, called EPIC-SR, showed that 2 of 333 patients who received a five-day course of Paxlovid were hospitalized compared to 8 of 329 who received placebo. The results were similar in a second analysis, Pfizer said, but barely missed statistical significance. Rates of adverse events were similar between the drug and placebo.14:27
minthosso maybe it's effective but the results aren't conclusive yet on that14:28
minthossorry for contributing to misinformation :/14:29
BrainstormUpdates for Saudi Arabia: +65 cases (now 550369), +1 deaths (now 8856), +50068 tests (now 32.1 million) since 23 hours ago — Switzerland: +8136 cases (now 1.1 million), +51 deaths (now 11862), +48268 tests (now 13.2 million) since 23 hours ago14:39
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Remember, this is before Omicron. With Omicron, ventilation and other measures to control airborne spread will be crucial. The variant has mutations that makes it much easier for the virus attach to our cells & viral load is greatly [... want %more?] → https://twitter.com/GANyborg/status/147074955440866100214:41
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Our covid times by @Ramireztoons pic.twitter.com/sXAM8N93kd → https://twitter.com/EricTopol/status/147075055302197248214:51
BrainstormNew from BBC Health: Covid: Family of woman lose appeal against end-of-life ruling: Doctors have previously described the woman as the "most complicated" Covid patient in the world. → https://www.bbc.co.uk/news/uk-england-cambridgeshire-5964199515:00
BrainstormUpdates for Sweden: +9472 cases (now 1.2 million) since 3 days ago — UAE: +110 cases (now 743004), +321306 tests (now 105.3 million) since a day ago15:04
BrainstormNew from The Indian Express (Health): Fashion: From Armani to Zegna, 22 Milan brands plan live runway shows → https://indianexpress.com/article/lifestyle/fashion/from-armani-to-zegna-22-milan-brands-plan-live-runway-shows-7671981/15:11
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): To explain:Doubling of cases every 2 days means the estimated 90-300.000 after 3 weeks, in yet another 8 days - a month from now - will be between (90-180-360-720-)1.440.000 and(300-600-1200-2400)-4.800.000 new cases per day w/o measures.Only strict [... want %more?] → https://twitter.com/GANyborg/status/147075839157650227415:21
BrainstormNew from StatNews: Health: CDC data indicate Omicron is starting to eat into Delta’s U.S. dominance → https://www.statnews.com/2021/12/14/cdc-data-indicate-omicron-is-starting-to-eat-into-deltas-u-s-dominance/15:31
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: Pfizer Covid pill retains 89% efficacy in full study; Senate committee holds hearing on FDA commissioner → https://www.statnews.com/pharmalot/2021/12/14/covid19-omicron-pfizer-fda-califf-medicaid/15:41
BrainstormUpdates for Kenya: +331 cases (now 256815), +2872 tests (now 2.9 million) since a day ago — Bangladesh: +295 cases (now 1.6 million), +3 deaths (now 28034), +22870 tests (now 11.2 million) since a day ago15:41
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Just published @NatureMedicine The most comprehensive assessment of the rare events of myocarditis, pericarditis, arrhythmias after COVID and AZ, mRNA vaccinesnature.com/articles/s4159… pic.twitter.com/eC5JOx0CmG → https://twitter.com/EricTopol/status/147076737874520473915:50
lastshellhey guys I hear people get sick aftet the booster what does that means I didn't get any reaction just sore arm ?15:51
minthosit's random, don't worry15:52
BrainstormNew from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Absolute nonsense @sajidjavid! Not only South Africa identified the #omicron and alerted the @WHO and the world. But we also helped the U.K to identify the the Alpha variant, see Sir @JeremyFarrar spike book. U.K. should be rewarding SA for scientific quality [... want %more?] → https://twitter.com/Tuliodna/status/147076824012516966616:00
BrainstormNew from r/COVID19: COVID19: Paper claiming a lack of evidence COVID-19 lockdowns work is retracted → https://www.reddit.com/r/COVID19/comments/rg97dv/paper_claiming_a_lack_of_evidence_covid19/16:20
LjLhaven't read the reasons (bit of in a hurry right now) but sometimes i cynically wonder if some of these retractions may not be based on scientific or COI reasons but simply pushed because the claims are undesirable16:22
xxLjL: I have no doubt that it sometimes happens, but I have no way of accurately telling when it happens16:32
xxit's more along the lines where if the study is just around the verge of being conclusive about some topic, it will get pushed towards conclusive/not-conclusive depending on something that is not science16:33
xxI've seen almost-shoddy studies get pushed out when they say something that's convenient, and almost-good studies retracted when they say something that is not convenient16:34
LjLWhat I will say is that I still favor lockdowns out of a cautionary principle, but given the oddities of these waves, I don't feel I can say for sure that there's a definite correlation with the waves16:36
BrainstormUpdates for Canada: +8902 cases (now 1.9 million), +32 deaths (now 29999) since 20 hours ago16:37
BrainstormNew from COVID on Twitter: Derek Lowe (@Dereklowe): Pfizer's Paxlovid protease inhibitor for coronavirus infection continues to show strong clinical data. But here's why it's likely to be used only in very high-risk cases:science.org/content/blog-p… → https://twitter.com/Dereklowe/status/147077851875790848516:39
TimvdeHmm, the local store here has new tests from Hangzhou AllTest, based on these results I should probably not buy them? https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.44.210044116:39
TimvdeAlthough the enclosed leaflet says that they perform really well16:40
LjLI bet16:42
LjLIf you look at the github Timvde I think I had some sites with tables of tests. Not sure if any will be any better than what you've already found though16:43
TimvdeI'll just wait until the NewGene tests are back in stock16:43
LjL(The sites not the tests)16:43
TimvdeLjL: de-facto gave me that link16:43
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): 2 new reports: up to 100-fold increase in neutralization activity vs Omicron after 3rd dose vaccinemedrxiv.org/content/10.110…biorxiv.org/content/10.110… pic.twitter.com/ssLN1NSAAr → https://twitter.com/EricTopol/status/147078135784457011216:49
BrainstormNew from COVID on Twitter: Jeffrey Barrett (@jcbarret): Fabulous thread, with clear visuals on how Omicron evades pre-existing immunity, and how boosting really helps counteract that. twitter.com/BalazsLab/stat… → https://twitter.com/jcbarret/status/147078574025468313717:09
BrainstormNew from Reddit (test): Tuesday 14 December 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://old.reddit.com/r/CoronavirusUK/comments/rgaox7/tuesday_14_december_2021_update/17:29
mrdataDredd, yes; but it doesnt stop the delusional from invoking contingency hypotheses ("he must have had low vitamin D and zinc status") to keep their belief that ivermectin works; they cite low reproduction rates in india and africa (dubious surveillance explains it better i think)17:37
BrainstormUpdates for Netherlands: +12808 cases (now 2.9 million), +74 deaths (now 20670) since 23 hours ago17:39
BrainstormNew from ClinicalTrials.gov: (news): Testing a Mindfulness/Acceptance-Based Smartphone App for Nurses Impacted by the COVID-19 Pandemic → https://clinicaltrials.gov/ct2/show/NCT0515703517:39
xxmrdata: I've seen interesting arguments for ivermectin recently.17:40
xxthey claim that lots of people have asymptomatic parasitic infections, and administering ivermectin kills the parasites, and that causes the immune system to starting doing something in order to clear up the parasitic remains, which incidentally also helps clear up coronavirus17:41
mrdata:/17:42
mrdatathere are infinite ideas about this17:42
ublxor just removes a burden allowing more immune resources to target other infections17:43
edcbacan parasites catch viruses ?17:44
xxtrue, things like CMV do stress the immune system persistently17:44
ublxremoving the most dubious data from ivermectin systematic reviews seems to leave positive results only in regions where worm infestation is endemic17:45
xxsomething about the immune system having to keep working on getting the viral load low17:45
xxif it was up to me, I'd treat everyone with ivermectin anyway, irrelevant of any corona thing. It's an extremely well studied medicine used for over half a century, and could be used to exterminate some human parasites forever.17:46
ublxthe argument has come from and been mirrored in several quarters. here's one prolix review: https://astralcodexten.substack.com/p/ivermectin-much-more-than-you-wanted17:49
BrainstormNew from ClinicalTrials.gov: Safety of Pediatric COVID-19 Vaccination: Conditions :    Pain;   Injection Site Reaction;   Adverse Drug Event → https://clinicaltrials.gov/ct2/show/NCT0515719117:49
ublxskip to end for summary, first point being: "Ivermectin doesn’t reduce mortality in COVID a significant amount (let’s say d > 0.3) in the absence of comorbid parasites: 85-90% confidence"17:50
xxyeah it wouldn't surprise me if people that die of covid do have some parasites already17:54
mrdatamight want to look at deaths from all causes, in these places17:54
xxnot necessarily due to lifestyle, but due to simply already having a poorly functioning immune system that hasn't managed to clear the parasitic infection17:54
BrainstormNew from ClinicalTrials.gov: (news): Measurment of Interleuukin-6 at Exhaled Breath Condensate of Covid-19 Patients and Post Covid-19 Patients With Lung Fibrosis Randomized Controlled Study → https://clinicaltrials.gov/ct2/show/NCT0515720417:59
mrdataif you have parasites, (or low vit D or zinc) you should be treated for those18:01
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): And now the good/bad news for RNA/J&J recipients. I'll put 3 images together so all the info is in one place.It's a lot of data but the patterns are clear. First, boosting works better than previous infection across all strains, WT, Delta, and [... want %more?] → https://twitter.com/michaelzlin/status/147080165994505011218:09
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Dual pandemic in London atm - both Delta and Omicron cases rising twitter.com/theosanderson/… → https://twitter.com/GANyborg/status/147080479490649292918:20
Dredd<xx> "Guest47: you're here often..." <- Hey, I mentioned the other day that if they want to they will. Please don't keep bringing it up 😉18:22
xxDredd: if you read further, you can see me mention that I am not asking them to do it, just that I was wondering why18:23
xxI'm in a few other channels unrelated to covid, where we deal with things like basic opsec, and we have a number of people thinking they are safer without an account, only to realize that they are actually broadcasting their home IP to everyone (due to no cloaks and no VPN/Tor)18:24
xxsimilarly with the issue of using the webchat which is less stable overall, and is prone to accidental tab closing or the browser unloading the tab (due to memory contention for example) than when one uses an actual irc client18:25
xxone could claim that web browsers have undergone more security hardening, sandboxing and review than irc clients, but they also have a much wider attack surface, so it is a question open to discussion18:26
* LjL logs the discussion using log4j18:27
xx${jndi:justkiddinglol}18:28
xxwait are you serious?18:28
BrainstormUpdates for Italy: +20665 cases (now 5.3 million), +120 deaths (now 135049), +776563 tests (now 127.1 million) since 23 hours ago — Germany: +40903 cases (now 6.6 million), +621 deaths (now 107029) since 23 hours ago18:29
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): There is no sign of let up of the Omicron wave in South Africa.Highest test positivity yet and ~24,000 new cases added today twitter.com/miamalan/statu… pic.twitter.com/Pn2aJtsfgS → https://twitter.com/EricTopol/status/147080542672363929618:30
Dredd<Guest47> "Hi folks, what do you make of..." <- Still a positive test per the instructions but seems to be moving in the right direction!18:30
xxso few places actually mention that it's spring/almost summer in SA compared to Europe/USA/Asia, which probably will affect the viral spread and possibly severity18:31
xx(so few people actually realize that southern hemisphere has seasons at different times)18:31
xxand a few people actually doubt the hemiSPHERE part of that :D18:31
LjLxx: no18:32
xxgood :)18:32
Dredd<Guest47> "I was gonna break self isolation..." <- Good call18:32
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): Another clear result is that J&J is inferior in all states. You can see across all states in tweet #4, or we can just look at the freshly vaccinated but unboosted state below. The freshly vaxxed state vs WT would reflect the conditions that earned J&J [... want %more?] → https://twitter.com/michaelzlin/status/147080932152505139218:39
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): But the most concerning thing is this: J&J+booster doesn't work as well against new variants compared to Moderna+booster or Pfizer+booster.You notice how J&J boosted is similar to Pfizer boosted for WT (especially if high Pfizer outliers removed), [... want %more?] → https://twitter.com/michaelzlin/status/147081191354617856418:49
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): Also because of the nice color-coding, we can see above that the JnJers who got Moderna boost (red) were better off than the one who chose a JnJ boost. Small n, but it's as we expect from the heterologous boost study. So can't claim the "wrong" [... want %more?] → https://twitter.com/michaelzlin/status/147081191544615322318:59
lastshellany good news ?19:01
JigsyI see the UK's "GET A BOOST NOW" thing is working out nicely.19:04
Jigsy"I was queing for five hours, and when I got in there, there were only two people jabbing."19:04
lastshellthat's nice19:04
JigsyThey're never going to hit 1,000,000/day like that.19:04
xxJigsy: I see a lot more people jabbing each other under the bridges these days, maybe you could try it there? :)19:04
ublxwhat are you doing hanging around under bridges, xx?19:05
lastshellhere in US we hoarding vaccines but what for19:05
lastshellhttps://www.cnbc.com/2021/12/14/us-covid-shot-distribution-faces-new-challenges-in-year-two-ups-vaccine-logistics-head-says.html19:05
Jigsy>When you see the homeless guy getting his COVID-19 vaccination for the 10th time this week19:05
JigsyThumbs up.jph19:05
Jigsy.jpg :D19:05
xxublx: protects me from rain19:05
lastshellCovid shots ‘returned or destroyed’ due to challenges19:05
JigsySpoke to my neighbor earlier.19:06
JigsySaid everyone's probably better off waiting until New Year.19:06
JigsySince pre-Christmas mad rush.19:06
lastshellI lost one family member and I know other family friends that also die19:06
lastshellunvaccinated19:06
BrainstormUpdates for Sri Lanka: +2545 cases (now 576194), +20 deaths (now 14661) since a day ago19:06
lastshellI now try to push vaccines when I found a person who doesn't want but is hard19:07
dTalInfuriatingly, I was waiting for two hours today, and most of that time the line was barely moving, and when I finally got to the jabby area the marshall there was all "it's been quiet all morning, what a sudden rush"19:07
dTalsomeone messed up the logistics hard19:08
lastshelldTal you got booster ?19:08
dTalI did19:08
lastshellnice19:08
dTalonly 4 months since my second jab19:08
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): This also means the limited humoral response of the J&J vaccine, long waved aside by Ad proponents who claimed the Ad vaccines had better T cell responses, does indeed lead to a meaningful functional disadvantage. → https://twitter.com/michaelzlin/status/147081607137231258119:08
lastshellwhy 4 months ?19:08
dTalbecause they want everyone to get a booster asap19:09
lastshellgot it19:09
dTalJigsy: I wanted my jab before christmas, to minimize the risk of giving it to my family19:10
ArsaneritI've been boostered but I never meet anybody.19:11
JigsyI've had my two.19:12
JigsyI think the 2nd was in July?19:12
JigsyAh, June.19:13
dTalI meant booster jab.19:13
dTalI have now had 3.19:13
lastshellhttps://ourworldindata.org/explorers/coronavirus-data-explorer?zoomToSelection=true&uniformYAxis=0&pickerSort=asc&pickerMetric=location&Metric=Cases+and+deaths&Interval=7-day+rolling+average&Relative+to+Population=true&Align+outbreaks=false&country=GBR~ITA~ESP19:14
dTalAt least, they tell me I have. I didn't see it go in at all. Could all be a ruse.19:14
lastshellI can see italy and spain going up19:14
lastshellin cases19:14
lastshelluk also is going up crazy19:15
lastshellim sure USA cases are not counted very well19:15
dTalI wouldn't say that UK is "going up crazy"19:16
dTalif you look at the trend lines on a log graph since July "freedom day", nothing especially remarkable is happening... yet19:16
lastshellyeah19:17
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): It would makes sense to deprecate J&J to the role of a booster to the RNA vaccines (where it seems to work well enough, see green dot below, and may give a broader CD8 T cell response). pic.twitter.com/D9yPj9RNSr → https://twitter.com/michaelzlin/status/147081942688262144319:18
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): Basically you need a RNA vaccine at some time to prime a wide B cell population for antibodies against variants. J&J does not substitute. If you don't do it earlier, you'll just have to do it later. I hope for the health of JnJers that @CDCgov and [... want %more?] → https://twitter.com/michaelzlin/status/147082145542003507319:28
BrainstormUpdates for United Kingdom: +59647 cases (now 11.0 million), +151 deaths (now 147085), +44328 vaccines (now 51.3 million) since 23 hours ago19:31
TimvdeI wonder if J&J is actually "bad" or just worse because it was only one dose19:33
LjL-MatrixI suspect one dose of AZ would be very similar19:34
TimvdeYes, but they gave 2 doses, and it seems that 2x AZ + mRNA gives better protection against variants than 3x mRNA (iiuc)19:35
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A 3rd report today which includes Moderna and J&J vaccine data for the first time"Neutralization of Omicron was undetectable in most vaccinated individuals [before boost]."1-shot J&J + mRNA boost not as high for neutralization as 3 dose [... want %more?] → https://twitter.com/EricTopol/status/147082622477568819219:47
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A 4th report documents both Prior Covid or 2-dose Pfizer vaccine provide low level neutralization vs Omicron, resolved by , and nearly all the monoclonal antibodies (except sotrovimab /S309 ) will lack effectivenessmedrxiv.org/content/10.110… pic.twitter.com/eXDMpl7cTs → https://twitter.com/EricTopol/status/147082921296982426019:57
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): @CDCgov @CDCDirector A couple of clarifications: As 2x RNA didn't produce nAbs vs variants (that's the recently vaxxed but unboosted case) but a 3rd shot of any sort did, it means 2x RNA may be needed to activate that broad memory B cell population. So [... want %more?] → https://twitter.com/michaelzlin/status/147083103420789964820:06
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): Second, J&Jers boosted with Moderna should do fine against Delta. J&J + Moderna gives even more nAbs against Delta than 2x Pfizer unboosted (below), and that correlates with 80% VE against Delta disease. This is consistent with the previous prediction [... want %more?] → https://twitter.com/michaelzlin/status/147083306782459494920:16
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): So in a sense JJ+RNA booster gets to where 2xRNA was to begin with (pic1 below). But it is worse than 3xRNA for variants, esp Omicron (pic2 below). And with decay we expect some loss of protection to Delta in the upcoming months (if we go by 2xPfizer [... want %more?] → https://twitter.com/michaelzlin/status/147083603431741849920:25
BrainstormUpdates for Spain: +26136 cases (now 5.4 million), +58 deaths (now 88542) since 23 hours ago — Morocco: +219 cases (now 951763), +11286 tests (now 10.6 million) since a day ago — Germany: +46353 cases (now 6.6 million), +626 deaths (now 107085) since 23 hours ago — France: +14890 cases (now 8.4 million), +237 deaths (now 121661) since 23 hours ago20:33
LjLi agree with this guy on just about everything he says here https://www-huffingtonpost-it.translate.goog/entry/luca-ricolfi-il-governo-sbaglia-cosi-fa-abbassare-la-guardia-ai-vaccinati_it_61b66323e4b04ae31a00e544?_x_tr_sl=it&_x_tr_tl=en&_x_tr_hl=it20:41
BrainstormNew from r/COVID19: COVID19: mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant → https://www.reddit.com/r/COVID19/comments/rgf22l/mrnabased_covid19_vaccine_boosters_induce/20:45
BrainstormNew from Politico: 2022: Boris Johnson hit by huge Tory rebellion as coronavirus curbs pass → https://www.politico.eu/article/boris-johnsons-tory-rebellion-coronavirus/20:54
BrainstormNew from Contagion Live: High-Flow Oxygen Reduces Need for Mechanical Ventilation in Severe COVID-19: Patients with severe COVID-19 who received high-flow oxygen therapy were less likely to need mechanical ventilation and had a shorter time to clinical recovery, [... want %more?] → https://www.contagionlive.com/view/high-flow-oxygen-reduces-need-for-mechanical-ventilation-in-severe-covid-1921:04
ArsaneritDid UK revert their freedom day?21:05
de-facto.title https://www.medrxiv.org/content/10.1101/2021.12.14.21267755v121:06
Brainstormde-facto: From www.medrxiv.org: mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant | medRxiv21:06
de-facto.title https://www.medrxiv.org/content/10.1101/2021.12.14.21267769v121:09
Brainstormde-facto: From www.medrxiv.org: mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant | medRxiv21:09
BrainstormNew from COVID on Twitter: Michael Lin, PhD-MD  (@michaelzlin): Made a mistake above regarding J&J as a booster. I misread a case of Moderna+Pfizer (blue dot) as Moderna+JJ (green dot). So this study doesn't say how well J&J works as a boost for RNA vax. The earlier study says J&J is inferior to RNA in boosting [... want %more?] → https://twitter.com/michaelzlin/status/147084924200035532821:23
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): Een degelijke modelling studie over waarschijnlijke impact van Omicron in het VK hieronder. Meest waarschijnlijke scenario: vergelijkbare golf dan in najaar 2020. Al wel met het effect van boosters meegerekend. cmmid.github.io/topics/covid19… twitter.com/BarnardResearc… → https://twitter.com/TWenseleers/status/147085235420343910721:32
Arsanerithow bad can hospitalisation be if 100% are triply vaccinated?21:35
BrainstormUpdates for Turkey: +21477 cases (now 9.1 million), +181 deaths (now 79503), +709653 tests (now 112.6 million) since a day ago21:36
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): We just talked Covid with @ASlavitt, who I consider a version of "Mr Phelps," taking on Mission(s) Impossible for helping the United States with its biggest healthcare challenges. Here's our conversation w/ @cuttingforstone @Medscapemedscape.com/viewarticle/96… → https://twitter.com/EricTopol/status/147085424098158182721:42
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Brilliant discussion, on whether omicron will displace delta or not. Thanks @RogerDobson14  twitter.com/trvrb/status/1… → https://twitter.com/GANyborg/status/147085701513210675421:52
BrainstormUpdates for Eswatini: +1222 cases (now 54731), +2 deaths (now 1254), +2016 tests (now 407052) since a day ago22:00
lastshellArsanerit are triple vax people in hospitals ?22:05
mrdata"Okay, fine, they misspelled “recovery” once. But they spelled it right the other time! That puts it in the top 50% for ivermectin papers!"22:06
BrainstormNew from Politico: Coronavirus: No cuddling the grandkids this Christmas, says Rutte as Dutch extend coronavirus measures → https://www.politico.eu/article/mark-rutte-christmas-cuddling-grandkids-dutch-coronavirus/22:11
gieroii[m]https://odysee.com/@logos:3/Warning-to-Humanity_Michael-Yeadon:022:20
BrainstormNew from Pfizer: U.S. FDA Approves Pfizer’s XELJANZ® (tofacitinib) for the Treatment of Active Ankylosing Spondylitis:  Anonymous (not verified) Tue, 12/14/2021 - 16:08 Tuesday, December 14, 2021 - 04:08pm NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: [... want %more?] → https://www.pfizer.com/news/press-release/press-release-detail/us-fda-approves-pfizers-xeljanzr-tofacitinib-treatment-022:21
LjLgieroii[m], what is that video about? the title sounds ominous.22:22
lastshella conspiracy video afik22:40
aradeshi had a jab yesterday. feel a bit tired today22:43
BrainstormUpdates for Algeria: +230 cases (now 213288), +4 deaths (now 6155) since a day ago22:44
LjLlastshell, yes he's banned22:49
LjLi gave them a few minutes to explain22:49
LjLif you're going to throw a link and then hide, might as well leave22:49
BrainstormNew from FDA Press Releases: FDA: Coronavirus (COVID-19) Update: December 14, 2021 → http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-december-14-202122:49
BrainstormUpdates for Gibraltar: +43 cases (now 7589), +1346 tests (now 430182) since a day ago — Aruba: +41 cases (now 16646), +1 deaths (now 178) since a day ago23:03
LjLGibraltar! they were 100% vaccinated ages ago already, right? did they get boosters23:03
LjL%cases Gibraltar23:03
BrainstormLjL: Gibraltar has had 7589 confirmed cases (22.5% of all people) and 100 deaths (1.3% of cases; 1 in 337 people) as of 31 seconds ago. 430182 tests were done (1.8% positive). 41075 were vaccinated (121.9%). +43 cases, +1346 tests since a day ago. See https://offloop.net/covid19/?default=Gibraltar&legacy=no23:03
LjLtheir wave is actually slowing down though, i guess Brainstorm was conveniently not showing it when it did take plae23:04
sdfgsdfgoof23:07
sdfgsdfgisn't Gibraltar the only country that successfully jabbed 100% of their population23:07
sdfgsdfgthe only place on earth where media can't blame the unvaccinated :P23:08
LjLnot the only anymore i think, at least for some decent approximation of 100%23:08
LjLbut anyway their wave basically didn't have deaths, unlike their prior wave23:08
LjLso they probably can't blame anyone, since the vaccines worked :P23:08
BrainstormNew from Ars Technica: Science: Omicron now 13% of cases in NY and NJ; health officials brace for sharp rise → https://arstechnica.com/23:08
Arsaneritlastshell: maybe a few (apart from in hospital unrelated to covid, of course)23:08
lastshellok23:09
LjLunfortunately they were not available last January when they had their peak of deaths23:09
Arsaneritsdfgsdfg: no, they didn't; they counted foreigners vaccinated in gibraltar, so the % calculation is wrong23:09
LjLhttps://offloop.net/covid19/?default=United%20Kingdom;Italy;Gibraltar&byPopulation=yes&cumulative=no&smooth=yes&legacy=no23:09
ArsaneritThe 100% vaccination figure for Gibraltar is wrong.23:09
ArsaneritIn German press I've seen talk of a 4th dose for summer already.23:10
Arsanerit31 seconds is recent23:10
finely[m]<xx> "ublx: you're right, however that..." <- It seem the current consensus is COVID is very infrequently spread by fomites. Alcohol is a mutagen. Plain soap, warm water and physical scrubbing is the best way to kill COVID on surfaces. A soapy washcloth in a ziplock bag is probably the best way to clean hand when out and about (if there are no sinks and plain soap).23:11
dTala mutagen? o no im gonna get hand cancer23:14
dTalI use so much alcohol. So much.23:15
BrainstormNew from CIDRAP: Pfizer says its pill may be effective against Omicron COVID-19: Stephanie Soucheray | News Reporter | CIDRAP News Dec 14, 2021 The pill cut non-Omicron hospitalization or death 89% if taken early in the disease course, company data show. → https://www.cidrap.umn.edu/news-perspective/2021/12/pfizer-says-its-pill-may-be-effective-against-omicron-covid-1923:27
trbpyey anti corona pill, that thing people waited for with aids for decades23:29
BrainstormNew from NPR: Cornell shuts down its Ithaca campus after significant signs of omicron variant found: The campus reported nearly 500 new cases of COVID-19 among the student body. The new omicron variant was detected "in a significant number" of [... want %more?] → https://www.npr.org/sections/coronavirus-live-updates/2021/12/14/1064197606/cornell-university-omicron-campus-shut-down-covid23:37
LjLde-facto, maybe you can't just guess, but would you guess the areas under these graphs are equivalent when smoothed? https://offloop.net/covid19/?default=United%20Kingdom;Germany;Italy;Netherlands;Sweden&byPopulation=yes&cumulative=no&leftTrim=650&legacy=no  because i'm wondering, Italy has almost the same case curve as Sweden now, but Italy's deaths are going UP, and Sweden's deaths are going DOWN (almost to zero). but, the two countries also seem to have a very23:39
LjLdifferent weekly pattern of deaths. are the looks of the graph deceiving me?23:39
BrainstormUpdates for India: +6986 cases (now 34.7 million) since 18 hours ago23:40
de-factohmm i am not sure23:44
de-factoeven more strange if you tick cumulative23:46
BrainstormNew from r/WorldNews: worldnews: "Omicron is a grave threat," UK Health Secretary Sajid Javid told members of Parliament, saying the strain was already estimated to be infecting 200,000 people a day in the U.K. "Scientists have never seen a COVID-19 variant that is capable of [... want %more?] → https://old.reddit.com/r/worldnews/comments/rgj1rj/omicron_is_a_grave_threat_uk_health_secretary/23:46
LjLde-facto, for what the WHO used to consider the 2nd best healthcare system in the world, Italy has a pretty bad deaths/cases ratio23:47
LjLbut yeah it's getting worse, and sweden's is getting better, and i don't understand why23:48
LjLwe aren't even close to hospital saturation23:48
LjLare we just better at dying23:48
de-factoage groups?23:48
LjLwell sweden isn't quite south africa either!23:48
de-factoIFR is an exponential of age, yet in that data age is an unknown23:48
de-factoe.g. if incidence happens in younger cohorts of the population its going to be exponentially less deadly23:49
LjLwell, italy has a higher vaccination rate than sweden, and afaik older age groups are by now "very vaccinated"23:50
LjLsweden has omicron, italy doesn't, and omicron is actually milder?23:51
LjLor conversely, italy has omicron invisibly, sweden doesn't, and turns out omicron is deadlier?23:51
LjLyou can also compare with the UK23:51
LjLcases are going up both in Italy and the UK, but Italy is still at less than half23:51
LjLand yet, the deaths are almost meeting23:51
de-factoitaly got a median age of 46.5 and Sweden got one of 41.123:54
LjLwow, that's more different than i imagined23:54
de-factoalso the high age group is exponentially overrepresented in fatalities to to the exponential IFR23:55
de-factoso comparing how the highest age groups changed during phases of pandemic may shed some light on interesting effects23:55
de-factopossibly even depletion of vulnerable at some points?23:55
LjLbut, in that case, Italy has had more cases and deaths historically, and clearly most of them have been in elderly and vulnerable23:56
BrainstormNew from CIDRAP: Jim Wappes: South Africa Omicron study finds drop in vaccine protection, fewer hospitalized → https://www.cidrap.umn.edu/news-perspective/2021/12/south-africa-omicron-study-finds-drop-vaccine-protection-fewer-hospitalized23:56
LjLso if either country had a depletion of vulnerable... that should be italy, not sweden23:56
de-factoi really do not have enough overview of either countries demographic dynamics23:57

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