| Brainstorm | New from NPR: California allows San Francisco to maintain existing COVID-19 masking rules: Starting Wednesday, a statewide mask mandate was back in effect statewide, but vaccinated San Francisco residents will be allowed to go without face coverings inside gyms [... want %more?] → https://www.npr.org/sections/coronavirus-live-updates/2021/12/15/1064608517/san-francisco-mask-mandate-california | 00:02 |
|---|---|---|
| dTal | Damn, it is scary. | 00:07 |
| Brainstorm | Updates for Argentina: +4819 cases (now 5.4 million), +31 deaths (now 116857), +59830 tests (now 26.8 million) since 23 hours ago | 00:08 |
| Brainstorm | New from COVID on Twitter: Derek Lowe (@Dereklowe): After a strong November rise in cases in MA (discounting the Thanksgiving notch in the data), the coronavirus numbers here are on some sort of ugly plateau. Will Omicron cases take off from these levels? You'd think so, but I have no real idea what comes next. . . [... want %more?] → https://twitter.com/Dereklowe/status/1471254786607656965 | 00:11 |
| LjL | dTal: yes, scary, but I see you figured out ;( | 00:25 |
| LjL | dTal: add that to "if you haven't had covid, you will"... | 00:25 |
| de-facto | So we see Omicron got a higher reproduction than Delta in populations that have a high seroprevalence (pre-existing immunity against Wuhan-Hu-1 or Delta or ancestors) | 00:28 |
| de-facto | the increased fitness of Omicron (due to its mutations) compared to Delta may have at least two causes: 1) New acquired immuno-evasive capabilities give it increased fitness in a pre-immunized population (compared to Delta) and 2) Optimizations that make it more fit (efficient) in its reproduction cycle in human hosts in general (regardless of the immune status) | 00:31 |
| de-facto | for 1) we already have the data of decreased neutralization titers, e.g. antibodies (against per-existing variants) indeed do not fit as well for Omicron as they do for Delta, so that would of course give Omicron an increased fitness in such a pre-immunized population | 00:33 |
| Brainstorm | Updates for Nigeria: +1424 cases (now 220020) since 23 hours ago — Mozambique: +975 cases (now 155495), +1 deaths (now 1946), +4053 tests (now 1.0 million) since a day ago — Zambia: +573 cases (now 212278) since a day ago — Angola: +89 cases (now 65565), +28095 tests (now 1.2 million) since 2 hours ago | 00:33 |
| diiirt | US Green Party Black Caucus 🌻@GPUSBlackCaucus Dec 14 | 00:35 |
| diiirt | Vaccine mandates/passports are among the most vile, unconstitutional, immoral, unscientific, discriminatory and outright criminal policies ever enforced upon the population and goes against everything the Green Party stands for under Social Justice. https://twitter.com/GPUSBlackCaucus | 00:35 |
| de-facto | for 2) we do not really have data yet, hence we do not really know if Omicron is better optimized (hence may have generic improved fitness) in human biology, this would be important to determine in order to estimate if the previously observed level of NPIs (such as air exchange, mask wearing etc) would have similar (or decreased/increased) level of impact on Omicron infection dynamics | 00:35 |
| Brainstorm | New from COVID on Twitter: Michael Lin, PhD-MD (@michaelzlin): In sum, 1x J&J is at most like 1 dose of RNA (seen as far back as phase1 antibody measurements). That's been reinforced by its use as a booster where it's worse than 1 dose of RNA.But 1xJ&J and 2xRNA (but not 1xRNA) were designated as vaccinated. [... want %more?] → https://twitter.com/michaelzlin/status/1471261916118937600 | 00:40 |
| dTal | LjL: it does say that vaccination is effective at preventing the nasty kind of long covid, at least | 00:42 |
| LjL | diiirt, joining and throwing that out there is basically spam. don't. | 00:43 |
| LjL | dTal, call me as usual the kind of annoying all-or-nothing person who likes "effective" to mean 95% ;( | 00:44 |
| diiirt | joining? | 00:45 |
| diiirt | I've been idling for months | 00:45 |
| dTal | "Assuming this difference continues over time, it might mean that vaccines reduce your chances of catching CFS from COVID by ~75-90% (50% reduction in likelihood of infection, and 50-80% reduction in long-term symptoms after a breakthrough infection). If they were 2-3% without vaccines, the odds of developing CFS with a vaccine become ~0.2-0.75%." | 00:45 |
| dTal | 90 is *almost* 95... | 00:45 |
| LjL | diiirt, well, i've never seen you speak, and that's your introduction | 00:45 |
| diiirt | what's your point | 00:45 |
| dTal | (I'm going with the bigger number because wishful thinking) | 00:45 |
| LjL | diiirt, my point is i'm asking you not to do that sort of thing again | 00:46 |
| diiirt | you a bully? telling me what i can say not say on fucking irc | 00:46 |
| LjL | ideally i'd be asking you not to have done it in the first place, but i recognize we can't change the past | 00:46 |
| LjL | an op, close enough | 00:46 |
| dTal | lol | 00:47 |
| dTal | angry PMs incoming... | 00:47 |
| LjL | nah | 00:47 |
| LjL | * LjL sets mode +g on LjL | 00:47 |
| dTal | oh, I always like to read them | 00:47 |
| LjL | me too | 00:48 |
| LjL | but i also like them to know i'm not seeing them | 00:48 |
| LjL | it's a delicate balance | 00:48 |
| LjL | also i always forget to unset +g later | 00:48 |
| LjL | and i miss everyone else's PMs | 00:48 |
| dTal | I find ignoring them the old fashioned way is effective | 00:48 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Let's Not Be Fatalistic About Omicron. We Know How to Fight It time.com/6128506/omicro… → https://twitter.com/Marc_Veld/status/1471266155608301577 | 00:59 |
| Brainstorm | Updates for Uruguay: +315 cases (now 403293), +1 deaths (now 6147), +9984 tests (now 4.2 million) since a day ago | 01:11 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: The Omicron Question ( https://www.zotero.org/groups/covid_links/items/SA834IU6 ) | 01:26 | |
| Brainstorm | Updates for Australia: +3392 cases (now 238922), +9 deaths (now 2126) since 23 hours ago — Switzerland: +17 deaths (now 11905) since 10 hours ago | 01:35 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: The Most Alarming Problem about Long COVID ( https://www.zotero.org/groups/covid_links/items/W76DGUBB ) | 01:36 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung ( https://www.zotero.org/groups/covid_links/items/2TBDK47X ) | 01:36 | |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): How much of the effect could be due to lower temperature sensitivity of omicron? Being able to multiply in the upper airways, with lower temperature, will be an advantage. Like other viruses that use a hit-and-run tactic of repeated infections.pnas.org/content/112/3/… → https://twitter.com/Marc_Veld/status/1471276766086017025 | 01:36 |
| de-facto | interesting summary about Omicron in SA https://www.discovery.co.za/corporate/news-room#/pressreleases/discovery-health-south-africas-largest-private-health-insurance-administrator-releases-at-scale-real-world-analysis-of-omicron-outbreak-based-dot-dot-dot-3150697 | 01:48 |
| de-facto | i am not sure how to link on their stupid website, click on the corresponding article | 01:49 |
| LjL | de-facto, the Discovery Health release preprint is already in Zotero btw, https://www.zotero.org/groups/4391070/covid_links/tags/South%20Africa/items/8GV2A8ZP/library | 01:52 |
| de-facto | oh nice, zotero really rocks if well maintained :)) | 01:53 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Everyone's familiar w/ the 5 stages of denial.For the pandemic, the US has invented the 5 denials of warnings (it won't happen here). The 5th warning: alarming Omicron signals from S Africa, UK, Denmark & Norway. With no aggressive counter-action. Headed to > 1 [... want %more?] → https://twitter.com/EricTopol/status/1471281296248766465 | 01:55 |
| LjL | have you noticed the articles have colored discs next to them? tags can have colors assigned, and i've tried to make some vaguely "logical" color coding, so for instance green is good things like vaccines and treatments (two different shades of green), violets is variants and mutations, orange is epidemiology, mortality, and also (maybe inappropriate) antibodies and immunity | 01:57 |
| de-facto | LjL, have you added the preprint "Frankfurt study" from Sandra Ciesek? This here, it seems it rapidly gets new versions https://www.medrxiv.org/content/10.1101/2021.12.07.21267432v4 | 01:57 |
| LjL | de-facto, no, it's not there, i think when you linked to the "three studies" (at least, it was just three back then), i looked at it later and it was light night so i didn't tell you but one of them seemed like it was probably the wrong URL, so maybe that one | 01:58 |
| LjL | oh wait no nevermind | 01:59 |
| LjL | it *is* already there | 01:59 |
| LjL | just, searching didn't find it | 01:59 |
| LjL | maybe Zotero is not so great :P | 01:59 |
| LjL | https://www.zotero.org/groups/4391070/covid_links/collections/4HEWBIA7/items/QWHAZHER/item-details | 02:00 |
| LjL | or maybe i mistyped when i searched, since "reduced" does quickly find it... | 02:00 |
| LjL | but yeah when you said "the frankfurt study" last time, you actually linked to https://www.medrxiv.org/content/10.1101/2021.08.12.21261952v2.full.pdf so i was puzzled | 02:02 |
| de-facto | oh yeah there it is indeed | 02:02 |
| LjL | i would like to be sure i have "all" the papers about Omicron neutralization studies. but even when they were "just" 5, i was confused as to which was which | 02:02 |
| LjL | (at least i assume now there's probably some more) | 02:03 |
| de-facto | i vaguely remember having heard 7 but not sure | 02:03 |
| sdfgsdfg | I thought more than a million cases was a total in a week or in region for all times etc... but they say a million per day | 02:04 |
| LjL | de-facto, it's maddening how *bad* of a tool Twitter is for keeping track of this. by which i mean it has a lot of extremely useful content from people who follow everything closely, but the tool itself, it's just so terribly ill-suited for the task it's being used for... | 02:05 |
| LjL | sdfgsdfg, who says a million per day? but anyway the UK is expecting 200k per day with Omicron, so that seems plausible :\ | 02:05 |
| sdfgsdfg | eric topol's post above a few lines | 02:06 |
| LjL | if a few big countries peak at the same time with Omicron... or even just when the US does, or India does... | 02:06 |
| sdfgsdfg | "Headed to > 1 million cases/day" | 02:06 |
| Brainstorm | Updates for Rwanda: +125 cases (now 100888), +9816 tests (now 3.7 million) since a day ago | 02:07 |
| de-facto | N-fold infection rate for a given doubling time t2 requires t = t2 * Log2(N) = t2 * Ln(N) / Ln(2) to establish | 02:12 |
| LjL | sdfgsdfg, a sort of thing that always strikes me when i think about it is, sometimes we're like (or at least TV is like) "Italy is going well, we only have 10000 cases per day", but then i remember, back in March 2020, when South Korea was being the second most-hit country after China, at some point we rearched 7000 - in total - and that was the moment we intersected Korea. and that's when i thought "we're screwed" | 02:12 |
| LjL | interesting how orders of magnitude can go from "terrible" to "this is fine" | 02:12 |
| de-facto | so for an order of magnitude (N=10) it would only need t = t2 *Ln(10) / Ln(2) = t2 * 3.32 ~ 6.64 -> 9.97 days for doubling times t2 = 2 -> 3 days | 02:14 |
| de-facto | an order of magnitude increase only requires one or one and a half weeks | 02:15 |
| Brainstorm | Updates for Martinique: +290 cases (now 46700), +12 deaths (now 749), +22049 tests (now 438296) since a day ago — Gabon: +55 cases (now 37681), +24350 tests (now 1.5 million) since a day ago | 02:34 |
| minthos | Italy did get a bit screwed early on, I remember hearing lots of complaints from hospital staff in the hardest hit areas, lots of people died | 02:59 |
| minthos | but then people stayed in their homes and the case load subsided | 02:59 |
| minthos | and the rest of the world was like "that wasn't so bad, nothing to worry about" | 03:00 |
| Brainstorm | New from r/WorldNews: worldnews: Omicron thrives in airways, not lungs; new data on asymptomatic cases → https://old.reddit.com/r/worldnews/comments/rhf8e3/omicron_thrives_in_airways_not_lungs_new_data_on/ | 03:01 |
| LjL | minthos, that's what Italy was also like when it was happening in China | 03:01 |
| LjL | it's literally what almost every country has been like, and it's miffling | 03:01 |
| LjL | now Italy is kinda being like that *again*, or rather, other countries are being like "why is Italy worried? their cases are so low compared to UK, France etc!" | 03:02 |
| LjL | "they should chill, not make more restriction" | 03:02 |
| LjL | uh guess what maybe it would be nice, this time, to try to *keep* them low | 03:02 |
| LjL | i don't know how some people reason, but unfortunately the way they reason largely makes it up to the policymakers | 03:02 |
| Brainstorm | New from Reddit (test): Covid2019: Ventilation is Critical to Battling Covid: Eastman Institute for Oral Health Developed a Tool to Help Improve Air Quality in Dental Office → https://old.reddit.com/r/Covid2019/comments/rhgi0s/ventilation_is_critical_to_battling_covid_eastman/ | 03:48 |
| LjL | de-facto, not entirely sure this is going to work smoothly, but i've added tinwhiskers' old "groups" of countries to Brainstorm, it won't report them as updates but it can query the cases, including worldwide | 03:54 |
| LjL | %cases | 03:54 |
| Brainstorm | LjL: the world has had 273.9 million confirmed cases (3.6% of all people) and 5.4 million deaths (2.0% of cases; 1 in 1420 people) as of a day ago. 4.4 billion tests were done (6.3% positive). 3.2 billion were vaccinated (42.3%). See https://offloop.net/covid19/?default=the%20world&legacy=no | 03:55 |
| LjL | %cases EU | 03:55 |
| Brainstorm | LjL: EU has had 50.6 million confirmed cases (11.3% of all people) and 876658 deaths (1.7% of cases; 1 in 511 people) as of a day ago. 901.0 million tests were done (5.6% positive). 320.3 million were vaccinated (71.5%). See https://offloop.net/covid19/?default=EU&legacy=no | 03:55 |
| LjL | %cases US republican states | 03:55 |
| Brainstorm | LjL: the world has had 273.9 million confirmed cases (3.6% of all people) and 5.4 million deaths (2.0% of cases; 1 in 1420 people) as of a day ago. 4.4 billion tests were done (6.3% positive). 3.2 billion were vaccinated (42.3%). See https://offloop.net/covid19/?default=the%20world&legacy=no | 03:55 |
| LjL | %cases US democratic states | 03:55 |
| Brainstorm | LjL: the world has had 273.9 million confirmed cases (3.6% of all people) and 5.4 million deaths (2.0% of cases; 1 in 1420 people) as of a day ago. 4.4 billion tests were done (6.3% positive). 3.2 billion were vaccinated (42.3%). See https://offloop.net/covid19/?default=the%20world&legacy=no | 03:55 |
| LjL | well maybe that is broken | 03:55 |
| LjL | is it just nitpicking on capitals? | 03:55 |
| LjL | %cases US Democratic states | 03:55 |
| Brainstorm | LjL: the world has had 273.9 million confirmed cases (3.6% of all people) and 5.4 million deaths (2.0% of cases; 1 in 1420 people) as of a day ago. 4.4 billion tests were done (6.3% positive). 3.2 billion were vaccinated (42.3%). See https://offloop.net/covid19/?default=the%20world&legacy=no | 03:55 |
| LjL | nope | 03:55 |
| LjL | ah, of course, states are not countries, i hadn't quite considered that ;( | 03:56 |
| LjL | that code really is a mess | 03:56 |
| lastshell | what code LjL ? | 04:09 |
| LjL | lastshell, my bot's covid code | 04:20 |
| LjL | %cases US Democratic states | 04:20 |
| Brainstorm | LjL: US Democratic states has had 24.6 million confirmed cases (14.3% of all people) and 390677 deaths (1.6% of cases; 1 in 439 people) as of a day ago. 39.1 million tests were done (62.9% positive). See https://offloop.net/covid19/?default=US%20Democratic%20states&legacy=no | 04:20 |
| LjL | %cases Schengen | 04:20 |
| lastshell | not able to find in https://github.com/ljl-covid/links | 04:20 |
| Brainstorm | LjL: Schengen has had 72.0 million confirmed cases (9.7% of all people) and 1.2 million deaths (1.7% of cases; 1 in 613 people) as of a day ago. 886.7 million tests were done (8.1% positive). 314.3 million were vaccinated (42.3%). See https://offloop.net/covid19/?default=Schengen&legacy=no | 04:20 |
| LjL | lastshell, it's not public, it's too horrible | 04:20 |
| lastshell | oh well, you can put in a repo and people will improve it | 04:21 |
| lastshell | but is up to you | 04:21 |
| lastshell | is perl / python ? | 04:22 |
| LjL | python 2 | 04:22 |
| LjL | i'm not sure the covid code in particular can be improved short of nuking it | 04:22 |
| LjL | think i will add "Western Europe" and "Eastern Europe" groups because i'm an 80s person | 04:24 |
| lastshell | %cases LAS | 04:25 |
| Brainstorm | ZeroDivisionError: integer division or modulo by zero (file "/home/brainstorm/brainstorm/bot/modules/covid.py", line 393, in covid) | 04:25 |
| lastshell | lmao | 04:25 |
| lastshell | you have airport code support ? | 04:26 |
| lastshell | %cases Nevada | 04:26 |
| Brainstorm | lastshell: Nevada, United States has had 466583 confirmed cases (16.1% of all people) and 8226 deaths (1.8% of cases; 1 in 351 people) as of 21 hours ago. 735891 tests were done (63.4% positive). See https://offloop.net/covid19/?default=Nevada&legacy=no | 04:26 |
| Brainstorm | lastshell: If you know of an official or otherwise good site for data about Nevada, with a reasonably short URL, please %tell LjL about it. | 04:26 |
| Brainstorm | New from r/COVID19: COVID19: Epidemiology of myocarditis and pericarditis following mRNA vaccines in Ontario, Canada: by vaccine product, schedule and interval → https://www.reddit.com/r/COVID19/comments/rhgvyz/epidemiology_of_myocarditis_and_pericarditis/ | 04:26 |
| lastshell | for south nevada we have this website with reports https://covid.southernnevadahealthdistrict.org/cases/reports/ | 04:28 |
| lastshell | (las vegas) | 04:28 |
| lastshell | for seattle wa this is a good source https://kingcounty.gov/depts/health/covid-19/data/daily-summary.aspx | 04:29 |
| lastshell | LjL ^ maybe you already have those places | 04:29 |
| LjL | lastshell, i'm afraid the bot only goes down to the state | 04:30 |
| LjL | and no the LAS thing is something i broke in the process of adding these groups and it should really be telling you it doesn't know the location | 04:31 |
| lastshell | ok | 04:32 |
| Brainstorm | Updates for United Kingdom: +78097 cases (now 11.1 million) since 15 hours ago — Netherlands: +78 cases (now 3.0 million) since 11 hours ago | 04:36 |
| LjL | %cases western europe | 04:43 |
| Brainstorm | LjL: Western Europe has had 93.7 million confirmed cases (11.0% of all people) and 1.4 million deaths (1.5% of cases; 1 in 611 people) as of a day ago. 1.3 billion tests were done (7.3% positive). 384.1 million were vaccinated (45.1%). See https://offloop.net/covid19/?default=Western%20Europe&legacy=no | 04:43 |
| LjL | %cases eastern europe | 04:43 |
| Brainstorm | LjL: Eastern Europe has had 24.0 million confirmed cases (11.4% of all people) and 535834 deaths (2.2% of cases; 1 in 393 people) as of a day ago. 167.5 million tests were done (14.3% positive). 79.5 million were vaccinated (37.8%). See https://offloop.net/covid19/?default=Eastern%20Europe&legacy=no | 04:43 |
| LjL | quite some striking differences here. not in cases, but in mortality, and testing. less of a difference in vaccinations than i thought... | 04:44 |
| Brainstorm | New from Novavax: Novavax Announces Submission of New Drug Application in Japan for Approval of COVID-19 Vaccine: -- Takeda submits application for TAK-019/NVX-CoV2373, the first protein-based COVID-19 vaccine candidate for NDA, to Japan's [... want %more?] → https://ir.novavax.com/2021-12-15-Novavax-Announces-Submission-of-New-Drug-Application-in-Japan-for-Approval-of-COVID-19-Vaccine | 05:04 |
| Brainstorm | Updates for Germany: +56902 cases (now 6.7 million) since 23 hours ago — Belgium: +11851 cases (now 2.0 million), +44 deaths (now 27729) since 23 hours ago — India: +343 deaths (now 476478) since 23 hours ago | 05:29 |
| Brainstorm | New from r/COVID19: COVID19: What does Omicron mean for future COVID-19 vaccinations? → https://www.reddit.com/r/COVID19/comments/rhilrf/what_does_omicron_mean_for_future_covid19/ | 06:01 |
| Brainstorm | New from This Week In Virology: TWiV 842: The clot thickens: TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome. → https://www.microbe.tv/twiv/twiv-842/ | 06:20 |
| minthos | 🎵 omicron is coming to toooown 🎵 | 06:23 |
| minthos | 9 cases detected in incoming travelers (quarantined), bars rumored to be allowed to open tomorrow | 06:24 |
| minthos | this story writes itself | 06:24 |
| Brainstorm | Updates for England, United Kingdom: +68007 cases (now 9.3 million), +129 deaths (now 127608) since 23 hours ago — Ohio, United States: +10588 cases (now 1.8 million) since 23 hours ago — Missouri, United States: +5282 cases (now 954483), +110 deaths (now 15832) since 23 hours ago — Scotland, United Kingdom: +5147 cases (now 777885), +21 deaths (now 9746) since 23 hours ago | 06:31 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Some great news that we desperately need. An in-depth assessment of the 1st potent and safe anti-Covid pillerictopol.substack.com/p/why-paxlovid… → https://twitter.com/EricTopol/status/1471351597070311427 | 06:39 |
| Brainstorm | New from r/COVID19: COVID19: Universal Coronavirus Vaccines — An Urgent Need → https://www.reddit.com/r/COVID19/comments/rhjmbu/universal_coronavirus_vaccines_an_urgent_need/ | 06:58 |
| Brainstorm | New from Science-Based Medicine: Tennessee hamstrings medical board fight against COVID misinformation and unproven treatments: A new Tennessee law hampers the state medical board's efforts to rein in COVID misinformation and will make [... want %more?] → https://sciencebasedmedicine.org/tennessee-hamstrings-medical-board-fight-against-covid-misinformation-and-unproven-treatments/ | 07:08 |
| Brainstorm | New from The Indian Express: World: Omicron is a dress rehearsal for the next pandemic → https://indianexpress.com/article/world/omicron-is-a-dress-rehearsal-for-the-next-pandemic-7675639/ | 07:26 |
| Brainstorm | Updates for Panama: +386 cases (now 481824), +3 deaths (now 7394), +9014 tests (now 4.3 million) since a day ago | 07:40 |
| Brainstorm | New from The Indian Express: World: In a time of crisis, a city in England fights isolation → https://indianexpress.com/article/world/england-city-frome-fights-loneliness-mental-health-7675627/ | 07:46 |
| Brainstorm | New from The Indian Express: World: Wuhan lab leak more likely origin of Covid-19, UK Parliament panel told → https://indianexpress.com/article/world/wuhan-lab-leak-more-likely-origin-of-covid-19-uk-parliament-panel-told-7675684/ | 07:55 |
| minthos | oh snap | 08:00 |
| minthos | this pandemic is such a clusterfuck | 08:01 |
| Brainstorm | New from MedicineNet: (news): CDC Warns of Coming Omicron Wave → http://www.medicinenet.com/script/main/art.asp | 08:04 |
| xx | minthos: anything big happen that I missed? | 08:12 |
| xx | or is that just a general feeling | 08:12 |
| minthos | I'm referring to the last link by brainstorm | 08:13 |
| minthos | expert tells the UK parliament that it probably was a lab leak | 08:13 |
| undefined_bob | there are no new data which suggest that | 08:15 |
| minthos | the old data always suggested that, and there is no new data to suggest otherwise | 08:16 |
| minthos | her argument is that if it wasn't a lab leak, we should have figured it out by now | 08:17 |
| undefined_bob | that is just not true | 08:23 |
| undefined_bob | there are no data which suggest that | 08:24 |
| minthos | did you read the article? | 08:24 |
| undefined_bob | I read many articles and studies about that, yes | 08:25 |
| minthos | why do you think the furin cleavage site evolved naturally instead of in a lab that was doing those kinds of experiments? | 08:26 |
| undefined_bob | i don't think you and i are qualified enough to make a valid statement about this that goes beyond speculation. Even proven experts can only speculate and talk about maybe/perhaps/could be and so on. | 08:29 |
| Brainstorm | New from r/COVID19: COVID19: SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity → https://www.reddit.com/r/COVID19/comments/rhlgbv/sarscov2_spike_protein_activates_tmem16fmediated/ | 08:42 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | December 16, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/rhlzdd/daily_discussion_thread_december_16_2021/ | 09:02 |
| xx | things leak from labs all the time, but fortunately the outside environment is extremely unlikely to cause further spread | 09:05 |
| xx | imagine a viral particle that has a special non-lipid coating, resistant to UV, oxygen, high temperatures and freezing, indefinitely stable, with full genetic code stability, fully able to evade imune system, and able to infect from just 1 viral particle | 09:07 |
| xx | that'd be bad | 09:07 |
| Brainstorm | Updates for Comoros: +13 cases (now 4589) since a day ago | 09:07 |
| Brainstorm | New from The Indian Express: World: Omicron could be dominant in Europe by mid-January → https://indianexpress.com/article/world/omicron-could-be-dominant-in-europe-by-mid-january-7675734/ | 09:12 |
| Brainstorm | New from BBC Health: (news): Covid: People urged to socialise carefully as cases hit new record → https://www.bbc.co.uk/news/uk-59677070 | 09:21 |
| Brainstorm | Updates for Maharashtra, India: +925 cases (now 6.6 million), +10 deaths (now 141298) since a day ago — Uttarakhand, India: +26 cases (now 344513), +1 deaths (now 7413) since a day ago | 09:32 |
| Brainstorm | New from The Indian Express: World: Omicron infects 70 times faster but may cause less severe disease: Study → https://indianexpress.com/article/world/omicron-infects-70-times-faster-but-may-cause-less-severe-disease-study-7675823/ | 09:41 |
| disconnect_me | https://twitter.com/BreesAnna/status/1470759488194248707 | 10:02 |
| Brainstorm | New from The Indian Express: World: Valneva says its booster works as a follow up to its own Covid-19 shot → https://indianexpress.com/article/world/valneva-booster-covid-19-shot-7675892/ | 10:10 |
| Brainstorm | Updates for Germany: +56902 cases (now 6.7 million) since 18 hours ago | 10:34 |
| sdfgsdfg | uk parliament panel's opinion is odd..... We will never know if this was a natural event, an accidental lab leak or .... <insert random conspiracy theory here> | 10:46 |
| Brainstorm | New from StatNews: Pharma: Poll: Omicron is forcing Americans to rethink some — but not all — of their holiday plans → https://www.statnews.com/pharmalot/2021/12/16/covid19-omicron-mask-pandemic-poll/ | 10:48 |
| Brainstorm | New from BMJ: Omicron: a failure to act with a global focus will continue the proliferation of new variants of covid-19: The emergence of the omicron variant of covid-19 serves as a stark reminder that while we have made progress in tackling covid-19 over the past two years, there is still much work to be done. We are... → http://www.bmj.com/content/375/bmj.n3095.short | 11:07 |
| Brainstorm | New from r/WorldNews: worldnews: German police uncover plot by anti-vaxxer group to murder pro-vaccine mandate governor-arrest 6 → https://old.reddit.com/r/worldnews/comments/rhnmpp/german_police_uncover_plot_by_antivaxxer_group_to/ | 11:17 |
| Brainstorm | Updates for Latvia: +934 cases (now 264965), +11 deaths (now 4419), +11563 tests (now 5.5 million) since 23 hours ago — Hong Kong: +10 cases (now 12507) since a day ago | 11:37 |
| Brainstorm | New from r/WorldNews: worldnews: What makes omicron spread so quickly? A new study offers a tantalizing clue : Goats and Soda : NPR → https://old.reddit.com/r/worldnews/comments/rho286/what_makes_omicron_spread_so_quickly_a_new_study/ | 11:56 |
| Brainstorm | New from COVID on Twitter: Emmanuel André (@Emmanuel_microb): In this latest study, we measure Omicron's immune evasion and the impact of this new variant on the efficacy of monoclonal antibodies.A very efficient collaboration between @KU_Leuven and @institutpasteur biorxiv.org/content/10.110… → https://twitter.com/Emmanuel_microb/status/1471435257727565825 | 12:24 |
| Brainstorm | Updates for Nepal: +160 cases (now 825176), +2 deaths (now 11567) since 23 hours ago — United Kingdom: +78126 cases (now 11.1 million) since 23 hours ago | 12:39 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Updated info on #Covid_19-related deaths during present wave in Gauteng, compared to earlier waves. Still low numbers but high rate of increase twitter.com/rid1tweets/sta… → https://twitter.com/GANyborg/status/1471443959553662977 | 12:43 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): South Africa has had a total of 277,700 excess natural deaths since May '20 while 90,226 Covid-related deaths are recorded acc. to worldometers.info. No. of excess deaths now rising more than no. of Covid-related deaths twitter.com/tomtom_m/statu… → https://twitter.com/GANyborg/status/1471445659442106374 | 12:53 |
| Brainstorm | New from ECDC: Data on testing for COVID-19 by week and country: Data in multiple file formats with information about testing volume for COVID-19, sorted by week and country, and updated on a weekly basis. → https://www.ecdc.europa.eu/en/publications-data/covid-19-testing | 13:12 |
| Brainstorm | New from BMJ: Covid 19: US cases rise amid omicron fears but booster shots offer protection, experts say: Some 800 000 Americans have died from covid-19, the highest number of any country in the world, and cases, deaths, hospital admissions, and local transmission are increasing as the threat of omicron... → http://www.bmj.com/content/375/bmj.n3098.short | 13:22 |
| Brainstorm | New from r/WorldNews: worldnews: Queen Elizabeth cancels pre-Christmas lunch as COVID cases soar → https://old.reddit.com/r/worldnews/comments/rhpndn/queen_elizabeth_cancels_prechristmas_lunch_as/ | 13:42 |
| Brainstorm | New from WHO Euro: How to enjoy the winter season and minimize COVID-19 risk: 5 tips for a safer holiday period: Minimizing COVID-19 risks is not a matter of chance, it is a matter [... want %more?] → https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2021/12/how-to-enjoy-the-winter-season-and-minimize-covid-19-risk-5-tips-for-a-safer-holiday-period2 | 13:51 |
| de-facto | .title https://twitter.com/chrischirp/status/1470094643757043722 <-- interesting thread about Omicron in UK with lots of links to data and graphs | 14:00 |
| Brainstorm | de-facto, the URL could not be loaded | 14:00 |
| de-facto | Prof. Christina Pagel: "THREAD on UK covid situation, Omicron and what's happening..." | 14:01 |
| Brainstorm | New from EMA: News and press releases: COVID-19: EMA recommends authorisation of antibody medicine Xevudy, CHMP, 16/12/2021: EMA’s human medicines committee (CHMP) has recommended authorising the monoclonal antibody Xevudy (sotrovimab) for the treatment of COVID-19. The... → https://www.ema.europa.eu/en/news/covid-19-ema-recommends-authorisation-antibody-medicine-xevudy | 14:20 |
| Brainstorm | New from EMA: News and press releases: EMA recommends approval for use of Kineret in adults with COVID-19, CHMP, 16/12/2021: EMA’s human medicines committee (CHMP) has recommended extending the indication of Kineret (anakinra) to include treatment of COVID-19 in adult patients... → https://www.ema.europa.eu/en/news/ema-recommends-approval-use-kineret-adults-covid-19 | 14:30 |
| Brainstorm | Updates for UAE: +200 cases (now 743352), +337670 tests (now 105.9 million) since 22 hours ago — Switzerland: +11023 cases (now 1.2 million), +32 deaths (now 11920), +75050 tests (now 13.4 million) since 23 hours ago — Germany: +57903 cases (now 6.7 million) since 22 hours ago — Bangladesh: +257 cases (now 1.6 million), +3 deaths (now 28041), +25203 tests (now 11.2 million) since a day ago | 14:31 |
| Brainstorm | New from Politico: Banks: ECB ends pandemic-era bond purchases, prepares smooth transition → https://www.politico.eu/article/ecb-ends-pandemic-era-bond-purchases-prepares-smooth-transition/ | 14:40 |
| aruns | How can I learn more about how the COVID vaccines work, and how vaccines work in general? | 14:45 |
| Brainstorm | New from r/WorldNews: worldnews: Omicon infects 70 times faster than previous COVID strains: study → https://old.reddit.com/r/worldnews/comments/rhqpdr/omicon_infects_70_times_faster_than_previous/ | 14:50 |
| undefined_bob | aruns: thanks for asking :) for example here is a long article which gives a nice overview over a lot of things regarding the vaccine: https://www.nature.com/articles/d41586-020-00502-w | 15:01 |
| undefined_bob | but its also a bit general. there are more specific ones, let me search in my links | 15:02 |
| undefined_bob | I know I've seen something | 15:02 |
| Brainstorm | Updates for Zambia: +861 cases (now 213139), +2 deaths (now 3673), +14311 tests (now 2.8 million) since 14 hours ago | 15:15 |
| undefined_bob | here is one more about the history of mRNA: https://www.nature.com/articles/d41586-021-02483-w | 15:15 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A year ago the first Covid vaccines were given. This @nature graph, adapted from @MaxCRoser @OurWorldinData, puts the speed of that remarkable advance in context, leading to untold lives saved and severe disease preventednature.com/articles/d4158… pic.twitter.com/FROkz1klVE → https://twitter.com/EricTopol/status/1471484721666269187 | 15:29 |
| aruns | Thanks undefined_bob | 15:38 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The anti-Covid pill (Paxlovid) is a veritable breakthrough. Just when we really need it. I wrote about it @SubstackInc. It's free. Please subscribe to followerictopol.substack.com/p/why-paxlovid… → https://twitter.com/EricTopol/status/1471488928616091654 | 15:39 |
| Brainstorm | Updates for Kenya: +943 cases (now 258557), +5787 tests (now 2.9 million) since 17 hours ago | 15:40 |
| Brainstorm | New from ScienceNews: Why it matters that health agencies finally said the coronavirus is airborne: Recognizing that the coronavirus spreads through the air reinforced the importance of wearing masks and altered public health recommendations. → https://www.sciencenews.org/article/coronvirus-covid-airborne-public-health-agencies | 16:09 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Summary graph of waning immunity for 4 vaccines over time, during Delta, against infections nature.com/articles/d4158… pic.twitter.com/mCyWtZNxfB → https://twitter.com/EricTopol/status/1471500425798975499 | 16:28 |
| Brainstorm | Updates for Canada: +6348 cases (now 1.9 million), +25 deaths (now 30056) since 23 hours ago | 16:30 |
| Brainstorm | New from Pfizer: EMA Issues Advice for Potential Early Use of Pfizer’s Novel COVID-19 Oral Antiviral Candidate: Anonymous (not verified) Thu, 12/16/2021 - 10:30 Thursday, December 16, 2021 - 10:30am EMA’s CHMP advice states that PAXLOVID™ [... want %more?] → https://www.pfizer.com/news/press-release/press-release-detail/ema-issues-advice-potential-early-use-pfizers-novel-covid | 16:38 |
| Brainstorm | New from Contagion Live: Prevention is the Best Treatment: Vaccines and Antimicrobial Resistance: Antimicrobial resistance is “the silent pandemic,” Dr. Leonard Friedland says, and vaccines are how we fight it. → https://www.contagionlive.com/view/prevention-is-the-best-treatment-vaccines-and-antimicrobial-resistance | 17:07 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Thursday 16 December 2021 Update → https://old.reddit.com/r/CoronavirusUK/comments/rhtscq/thursday_16_december_2021_update/ | 17:17 |
| Brainstorm | New from LitCovid: (news): Minimally Invasive Tissue Sampling Findings in 12 Patients With Coronavirus Disease 2019. → https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/34910166 | 17:27 |
| Brainstorm | Updates for Netherlands: +16374 cases (now 3.0 million), +56 deaths (now 20768) since 18 hours ago | 17:32 |
| Jigsy | 80K today. | 17:58 |
| Jigsy | Well, 88K. | 17:58 |
| LjL | I don't know anything about sotruvimab but see it mentioned a lot recently, is it "just another mAb" (not that there's anything wrong with that) or is there anything special to it? | 18:02 |
| LjL | Jigsy: at this point Omicron must be the majority in the UK | 18:05 |
| Jigsy | Yup. | 18:10 |
| lastshell | cases are up in UK but deaths are not rising yet | 18:10 |
| Jigsy | Deaths are 150/day. | 18:11 |
| Brainstorm | New from The Indian Express: World: US faces a double coronavirus surge as omicron advances → https://indianexpress.com/article/world/us-faces-a-double-coronavirus-surge-as-omicron-advances-7676645/ | 18:26 |
| LjL | lastshell: they started going sharply up only like two days ago | 18:29 |
| lastshell | :( | 18:30 |
| Brainstorm | Updates for United Kingdom: +24752 cases (now 11.1 million), +1713420 tests (now 382.6 million) since 22 hours ago — Germany: +65057 cases (now 6.7 million), +702 deaths (now 108066) since 22 hours ago | 18:35 |
| LjL | Hmm I guess Brainstorm broke the UK update into two, or my tinkering yesterday messed up the database | 18:37 |
| lastshell | LjL I recommend ipython and ipdb or regular pdb | 18:41 |
| LjL | de-facto: did you know the EMA actually already gave emergency approval for Molnupuravir, and Denmark is recommending it? | 18:42 |
| LjL | (They also gave the go ahead for Paxlovid at least) | 18:42 |
| Brainstorm | New from The Indian Express: World: UK Covid-19 cases hit record high for second day → https://indianexpress.com/article/world/uk-covid-19-cases-hit-record-high-for-second-day-7676662/ | 18:46 |
| Brainstorm | New from COVID on Twitter: Michael Lin, PhD-MD (@michaelzlin): And vulnerable 2xRNA-vaccinated can schedule that 3rd dose before 6mo by declaring themselves immunocompromised. This policy was from back when Pfizer+Moderna's studies found a need, while J&J didn't do studies although JJ was even less [... want %more?] → https://twitter.com/michaelzlin/status/1471538288838119426 | 18:55 |
| Brainstorm | Updates for Italy: +26104 cases (now 5.3 million), +123 deaths (now 135301), +1352919 tests (now 128.4 million) since a day ago | 18:59 |
| Dredd | So my dad's household seem like they might all have got covid ☹️ | 19:01 |
| lastshell | oh man Dredd I hope they are vaccinated | 19:01 |
| Dredd | They are but not boosted yet | 19:03 |
| dTal | well they got the natural booster now | 19:04 |
| Brainstorm | New from Contagion Live: us: Mixing 2-Dose Primary COVID-19 Vaccines Can Increase Access While Preserving Protection → https://www.contagionlive.com/view/mixing-2-dose-primary-covid-19-vaccines-can-increase-access-while-preserving-protection | 19:05 |
| Dredd | Probably Omicron of they have got it | 19:05 |
| Dredd | Waiting for PCR results | 19:06 |
| lastshell | vitamin d/c, zinc, | 19:06 |
| Dredd | They all take supplements so not worried about deficiencies in them | 19:06 |
| lastshell | :thumbsup: | 19:07 |
| Dredd | Mostly worried about my dad as he's very vulnerable to this sort of thing | 19:07 |
| lastshell | :( | 19:09 |
| lastshell | im seriously thinking to cancel xmas again :( | 19:11 |
| lastshell | Dreed maybe a monoclav antibodies treatment I hear early always helps | 19:11 |
| lastshell | Dredd ^ | 19:12 |
| dTal | I don't understand people. There is an entire subculture in the UK that not only refuses to get vaccinated, but refuses to take lateral flow tests. | 19:14 |
| dTal | If you require a negative test to attend an event, they will not go. And they will complain that you are infringing their right to make personal choices. | 19:14 |
| lastshell | I assuume only USA have idiots looks like are in all around thw world | 19:14 |
| Dredd | I decided to be the change I want to see in the world today and engaged in the YouTube comments on a covid video... | 19:19 |
| lastshell | oh youtube is super toxic Dredd | 19:21 |
| Dredd | There's no way to link to comments too which is rubbish | 19:25 |
| LjL | Dredd, in theory there is, but it never actually goes down to the comment in question when i use them | 19:25 |
| * Dredd uploaded an image: (1099KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/zRuZTGcYMtqCBieyXDvRDAXd/Screenshot_20211216-182326.jpg > | 19:26 | |
| * Dredd uploaded an image: (1194KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/oaOXtEnWDyCQZlOWRPilFJWj/Screenshot_20211216-182403.jpg > | 19:26 | |
| * Dredd uploaded an image: (1223KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/qkqHYLCQVgMwUMYSrnXfpszT/Screenshot_20211216-182433.jpg > | 19:26 | |
| * Dredd uploaded an image: (352KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/xlFQWVuzHXrQvGGGErooSeIQ/Screenshot_20211216-182447.jpg > | 19:26 | |
| Dredd | There's some screenshots anyway | 19:26 |
| Dredd | LjL: Ah, the app doesn't have a share option | 19:26 |
| * LjL cries | 19:27 | |
| Dredd | I feel like this is a valid use of images 😛 | 19:27 |
| lastshell | you are to polite for youtube comments | 19:27 |
| Dredd | I doubled down on engaging | 19:27 |
| Dredd | Only the worst I didn't reply to at all | 19:28 |
| Dredd | I was told by several people that I basically know the wrong facts lol | 19:28 |
| LjL | Dredd, it's so valid you literally triggered my bot's spam function except you're lucky he's not opped :P <Brainstorm> Dredd quieted in ##covid-19 | 19:28 |
| Dredd | Lol | 19:29 |
| * Dredd rubs Brainstorm @Brainstorm:libera.chat with a freshly opened plumbus | 19:30 | |
| * Brainstorm starts to misdirect Dredd with some unfluctuating boding | 19:30 | |
| Dredd | These people are so certain they are right and know the truth but they just repeat the stock party lines and spout patently wrong ideas | 19:32 |
| Dredd | Then claim that they are correct because everything else is doing because big pharma profit or because Javid wants to make us sick with jabs or some such | 19:32 |
| Dredd | LjL @LjL:libera.chat: ohh, framework is available to preorder in UK now | 19:33 |
| Dredd | Germany and France to | 19:33 |
| LjL | oh | 19:33 |
| LjL | i didn't get my email :[ | 19:33 |
| Dredd | Maybe it's a keyboard layout thing more than anything? | 19:34 |
| LjL | Dredd, possibly, there was quite some discussion over keyboard layouts on their forums | 19:35 |
| LjL | but i would be fine with a UK layout... a bit less so with a US one since that's physically different :P | 19:35 |
| LjL | and there's no *laws* that say you have to sell with a certain keyboard layout | 19:35 |
| Dredd | Does every country have their own one? | 19:35 |
| LjL | mostly, yeah | 19:35 |
| LjL | the Netherlands is unusual in that most people there use the US layout even though in theory an NL layout exists | 19:35 |
| Dredd | I can touch type on a US layout despite never having had one because of the number of misconfigured locales over SSH I've had to deal with | 19:37 |
| Brainstorm | Updates for Spain: +28900 cases (now 5.4 million), +48 deaths (now 88667) since 22 hours ago — Canada: +6320 cases (now 1.9 million), +26 deaths (now 30061) since 23 hours ago | 19:37 |
| dTal | Dredd: well I too am being the change yadda yadda for the first time today | 19:40 |
| dTal | someone in a hippy-newage whatsapp group I'm in *timidly* suggested that maybe people should do lateral flow tests before their planned public-access cuddle puddle on Saturday | 19:41 |
| LjL | Dredd, i think that's true of any of us who's dealt with DOS or BIOS or any misconfigured computer :D | 19:41 |
| dTal | and someone immediately responded with - well, | 19:41 |
| dTal | "While I don't want anyone to feel unsafe, I want to speak the truth from my heart that I would be deeply deeply unhappy if such a guideline were to introduced. Intribe has felt to me such a haven from the restrictions, where every body is welcome regardless of testing. This feels extremely important at a time of such division among us. Even the discussion of it can cause division - I can't emphasise enough, I feel it would be the wrong choice, and | 19:42 |
| dTal | potentially put off a lot of more free spirited people who want the autonomy to make their own choices and who deserve to be respected and welcomed regardless. I would welcome anyone who is tested or vaccinated and I want to be equally welcomed for my choice to not be. No more division or restriction 💜" | 19:42 |
| dTal | sorry, but you should see this | 19:42 |
| * Dredd uploaded an image: (27KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/pDOAEySOTkmETyTkJCOdAszK/Screenshot_20211216-154035~2.jpg > | 19:42 | |
| LjL | Dredd, but mostly, almost every european language has different diacritics, so that's why we need different layouts, apart from historical reasons that regrettably cause the existence of QWERTZ and AZERTY ;( | 19:42 |
| Dredd | de-facto @de-facto:libera.chat mentioned in UK news ^ | 19:42 |
| Dredd | 😛 | 19:42 |
| dTal | so couched in all the hippy language is "my right to not take a test trumps your right to not catch covid from me" | 19:43 |
| Brainstorm | New from COVID on Twitter: Jeffrey Barrett (@jcbarret): Gah, may mean that admissions numbers still aren't going to be a sufficiently informative metric, and will need to watch MV beds & ICU. → https://twitter.com/jcbarret/status/1471550672067776513 | 19:43 |
| LjL | dTal, i find it apt that they spelled "every body" instead of "everybody", given what their choices will likely take them | 19:43 |
| dTal | and I've actually responded this time. This is a huge group, and it's so full of irresponsible types / planning only irresponsible events that I'm on the cusp of leaving, so I decided to shoot my shot and - in my best hippy-language - ask what was so bad about testing | 19:44 |
| dTal | you know, since they're free and take a few minutes | 19:45 |
| Dredd | dTal: same logical error as the person going on about the economic cost of covid measures in that YouTube. They behave as though the restrictions are "just because" so they are being discriminated against or restricted for no reason | 19:45 |
| dTal | we'll see if it landed | 19:45 |
| Dredd | Which is such bs | 19:45 |
| dTal | at the rate Omicron is going, and if the reports of what they did at the last meetup are accurate, everyone who attends on Saturday is getting covid | 19:47 |
| dTal | so it'll be nice to be on record as being right | 19:47 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): London now has a doubling time of 1.5 days (PCR tests screened and positive for omicron) twitter.com/dan_grey/statu… → https://twitter.com/GANyborg/status/1471552310987874319 | 19:53 |
| de-facto | wow. this is a disaster | 19:54 |
| dTal | yeah the curve is gonna be way ahead of the official numbers with that kind of acceleration | 19:56 |
| de-facto | .title https://www.gov.uk/government/publications/covid-19-omicron-daily-overview | 19:56 |
| Brainstorm | de-facto: From www.gov.uk: COVID-19: Omicron daily overview - GOV.UK | 19:56 |
| de-facto | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1041833/20211216_OS_Daily_Omicron_Overview.pdf | 19:56 |
| LjL | de-facto, did you see Topol also spoke against the Merck pill? | 20:02 |
| dTal | well, someone replied to my post, gently shutting it down as "best discussed in person" | 20:04 |
| dTal | because it's a "tricky subject" | 20:05 |
| dTal | which I feel kind of wilfully misses the point that meeting in person without testing is, you know, dangerous | 20:05 |
| de-facto[m] | 2021-12-16: UK regional doubling times for the number of test with SGTF, data up to 18h00 15 December 2021. | 20:05 |
| de-facto[m] | East Midlands 1.89 (1.48-2.64); East of England 1.64 (1.29-2.25); London 1.5 (1.21-1.96); North East 1.55 (1.24-2.06); North West 1.84 (1.62-2.14); South East 1.65 (1.43-1.95); South West 2.18 (1.64-3.26); West Midlands 1.54 (1.26-1.98); Yorkshire and Humber 1.53 (1.21-2.09) | 20:05 |
| de-facto | 2021-12-16: UK regional doubling times for the number of test with SGTF, data up to 18h00 15 December 2021. | 20:07 |
| de-facto | East Midlands 1.89 (1.48-2.64); East of England 1.64 (1.29-2.25); London 1.5 (1.21-1.96); North East 1.55 (1.24-2.06); North West 1.84 (1.62-2.14); South East 1.65 (1.43-1.95); South West 2.18 (1.64-3.26); West Midlands 1.54 (1.26-1.98); Yorkshire and Humber 1.53 (1.21-2.09) | 20:08 |
| de-facto[m] | LjL: nope have not seen that, but i can imagine why... | 20:08 |
| LjL | de-facto[m], i don't actually remember where i saw it right now and the logs aren't helping, except for this: "On Vioxx, Topol wrote: "Sadly, it is clear that Merck's commercial interest exceeded its concern about the drug's toxicity" (2). | 20:09 |
| LjL | i thought i'd seen it on twitter though, or substack | 20:10 |
| LjL | ah https://erictopol.substack.com/p/why-paxlovid-is-a-just-in-time-breakthrough has a "What About Molnupiravir?" section, i think that's what i saw | 20:10 |
| Brainstorm | New from COVID on Twitter: Jeffrey Barrett (@jcbarret): This is like the 12th US university I've seen detecting a massive Omicron outbreak. Hint: the difference is not that Omicron is exclusively on college campuses, it's that they're looking. twitter.com/bhrenton/statu… → https://twitter.com/jcbarret/status/1471556720698798083 | 20:12 |
| de-facto[m] | its principle of action is very fundamental, hence unlikely to be circumvented by mutation, but inducing a fatal error catastrophe by increasing lowering replication fidelity does not sound good to me because 1) how do we know what happens in the transition from fatal to fit fidelity in reproduction and 2) what does it do to protein synthesis via mRNA in normal cell functions, what effect would be seen by lowering fidelity there? | 20:13 |
| de-facto[m] | also its efficacy against hospitalization (originally thought ot be 50%) went down to 30% or such | 20:14 |
| de-facto[m] | 1) kind of depends on how close to the error limit the usual SARS-CoV-2 reproduction takes place and 2) depends on how long the substance is present in the body | 20:15 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Universal Coronavirus Vaccines — An Urgent Need ( https://www.zotero.org/groups/covid_links/items/8U2KMH7S ) | 20:16 | |
| LjL | i hope the EU has optioned some Paxlovid | 20:17 |
| LjL | the US has already bought 10 million apparently, but only 200k are going to be available quickly | 20:17 |
| de-facto | i would prefer something specific to SARS-CoV-2 yeah like Paxlovid | 20:17 |
| de-facto[m] | damn irc, i cant talk fromt here | 20:17 |
| de-facto[m] | ah now it works | 20:17 |
| LjL | why? | 20:17 |
| de-facto[m] | stupid buggy network | 20:18 |
| de-facto | no idea | 20:18 |
| de-facto | if its highly specific to SARS-CoV-2 there may be less side effects, but it also may have a higher probability for evasion by antigenic drift | 20:20 |
| friedrice | topol has a substack out today on paxlovid | 20:20 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Omicron is getting more defined ( https://www.zotero.org/groups/covid_links/items/TNH2S779 ) | 20:21 | |
| de-facto | so maybe a cocktail of several highly specific SARS-CoV-2 drugs may mitigate evasion risk if targeting the same mechanism from different "angles" (as in molecular affinity to the same region) | 20:21 |
| friedrice | 'Why Paxlovid is a Just-in-Time Breakthrough' | 20:21 |
| de-facto | .title https://erictopol.substack.com/p/why-paxlovid-is-a-just-in-time-breakthrough | 20:23 |
| Brainstorm | de-facto: From erictopol.substack.com: Why Paxlovid is a Just-in-Time Breakthrough - by Eric Topol | 20:23 |
| de-facto | .title https://www.science.org/content/blog-post/pfizer-s-paxlovid-holds | 20:27 |
| Brainstorm | de-facto: From www.science.org: Pfizer's Paxlovid Holds Up | Science | AAAS | 20:27 |
| Brainstorm | New from r/COVID19: COVID19: Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses → https://www.reddit.com/r/COVID19/comments/rhxm60/genomic_determinants_of_furin_cleavage_in_diverse/ | 20:31 |
| Brainstorm | Updates for Eswatini: +1642 cases (now 57842), +1 deaths (now 1255), +1979 tests (now 410799) since 23 hours ago — Burundi: +279 cases (now 21422) since 23 hours ago — Congo: +113 cases (now 19179), +6 deaths (now 365) since 8 days ago — S. Sudan: +80 cases (now 13049) since 23 hours ago | 20:39 |
| friedrice | oh sorry | 20:49 |
| Brainstorm | New from r/WorldNews: worldnews: Dutch princess' 18th birthday party broke Covid-19 rules → https://old.reddit.com/r/worldnews/comments/rhy9ql/dutch_princess_18th_birthday_party_broke_covid19/ | 20:50 |
| Brainstorm | New from CIDRAP: COVID-19 Scan for Dec 16, 2021: Vaccine-generated Omicron antibodies Review of early CDC COVID-19 test errors → https://www.cidrap.umn.edu/news-perspective/2021/12/covid-19-scan-dec-16-2021 | 20:59 |
| Brainstorm | Updates for Malawi: +475 cases (now 63408), +1 deaths (now 2311), +3143 tests (now 456392) since 22 hours ago | 21:04 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): So what this study should say is: we found some bat SARS-related CoVs that are just one or a few mutations away from having a furin cleavage site, but none of them actually have a furin cleavage site even as a minor variant. (6/n) → https://twitter.com/jbloom_lab/status/1471573175829811200 | 21:19 |
| Dredd | Heh, I'm in the South west so the least bad part of the UK | 21:30 |
| Brainstorm | New from Johnson&Johnson: (news): Penny Heaton, M.D., Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC Remarks As Prepared for the Centers for Disease Control and Prevention [... want %more?] → {"param":"apiKey","title":"Invalid authorization","type":"INVALID_AUTHORIZATION","status":401,"detail":"Expected authentication to be provided in \"apiKey\" query param"} | 21:31 |
| Brainstorm | New from NPR: CDC advisers vote to narrow use of J&J vaccine due to concerns about rare blood clots: The recommendation was prompted by the occurrence of a rare and sometimes fatal blood clotting problem known as TTS. More than 16 million [... want %more?] → https://www.npr.org/sections/coronavirus-live-updates/2021/12/16/1064909742/cdc-vote-narrow-use-of-johnson-and-johnson-covid-vaccine | 22:01 |
| LjL | (also due to it being useless) | 22:04 |
| xx | don't all the main vaccines cause rare blood clots? | 22:09 |
| xx | pretty sure just enjoying life causes blood clots at times anyway | 22:10 |
| LjL | xx, this type of blood clots is much more serious than average | 22:13 |
| LjL | it's the same thing that caused AZ to be largely withdrawn | 22:13 |
| LjL | mRNA vaccines also register an increase in blood clotting, but not this particular thing | 22:13 |
| xx | I imagine the average blood clot in the brain/heart is pretty serious | 22:14 |
| xx | yet again, I can't find reliable data on sputnik/sinovax and other alternative vaccines regarding these blood clots | 22:15 |
| xx | maybe they don't cause them, maybe the info is suppressed :( | 22:15 |
| LjL | https://en.wikipedia.org/wiki/Embolic_and_thrombotic_events_after_COVID-19_vaccination | 22:15 |
| xx | sputnik and AZ are "pretty much the same", except that sputnik uses human Ad and AZ uses chimp one | 22:19 |
| LjL | well, so is J&J | 22:19 |
| LjL | its solution to possible loss of efficacy on the second shot due to using the same adenovirus was... doing only one shot :P | 22:20 |
| LjL | but as to the rest, it's an adenovirus vaccine similar to AZ and Sputnik | 22:20 |
| xx | yeah, so I'd imagine if JJ might cause blood clots, AZ might cause blood clots, then there should be some Sputnik blood clots (roughtly speaking) | 22:20 |
| Brainstorm | New from CIDRAP: Novavax COVID vaccine shows 90.4% efficacy against infection: Mary Van Beusekom | News Writer | CIDRAP News Dec 16, 2021 The vaccine can be stored for up to 6 months at refrigerator temperatures. → https://www.cidrap.umn.edu/news-perspective/2021/12/novavax-covid-vaccine-shows-904-efficacy-against-infection | 22:20 |
| de-facto | you have to be aware that virus vectors are grown in some sort of cells, so separating them from all the things that make up a cell is a challenge | 22:23 |
| de-facto | mRNA is just replicated from DNA template with a molecule | 22:24 |
| Brainstorm | New from r/COVID19: COVID19: Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection → https://www.reddit.com/r/COVID19/comments/ri0gsx/antibody_response_and_variant_crossneutralization/ | 22:30 |
| Brainstorm | New from COVID on Twitter: Michael Lin, PhD-MD (@michaelzlin): Would have been better if they indicated J&J is unpreferred because it doesn't even meet efficacy requirements as a 1-shot vaccine against current strains of SARS-CoV-2, but indeed there's also a safety issue. Not efficacious and less safe... Which [... want %more?] → https://twitter.com/michaelzlin/status/1471594552582496259 | 22:39 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The holidays should be a time for getting together with friends and family, but instead we have a double dose of coronavirus strains—Delta and Omicron. How to deal with it? latimes.com/opinion/story/… my oped @LATimes pic.twitter.com/mETILLCmDn → https://twitter.com/EricTopol/status/1471596786682761217 | 22:49 |
| Brainstorm | New from CIDRAP: Omicron boosts COVID-19 surges in Denmark, UK: Lisa Schnirring | News Editor | CIDRAP News Dec 16, 2021 Of Denmark's Omicron patients, 75% were fully vaccinated, and 9% had received a booster shot. → https://www.cidrap.umn.edu/news-perspective/2021/12/omicron-boosts-covid-19-surges-denmark-uk | 22:58 |
| Brainstorm | New from Pfizer: kimkevin: Pfizer and BioNTech Submit Supplemental Biologics License Application for U.S. FDA Approval of COMIRNATY® in Adolescents 12 Through 15 Years of Age → https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-submit-supplemental-biologics-license | 23:08 |
| de-facto | .title https://www.youtube.com/watch?v=uOirzrAvvBc <-- Lauterbachs first press conference as health minister (in German lang) | 23:11 |
| Brainstorm | New from Politico: Airlines: Draghi puts health above unity as EU struggles to find footing on Omicron → https://www.politico.eu/article/draghi-puts-health-above-unity-as-eu-struggles-to-find-its-footing-on-omicron/ | 23:17 |
| de-facto | yes we definitely need more testing | 23:21 |
| de-facto | mandatory testing | 23:21 |
| Brainstorm | New from Johnson&Johnson: (news): Johnson & Johnson Statement on its COVID-19 Vaccine Following CDC ACIP Meeting → https://www.jnj.com/johnson-johnson-statement-on-its-covid-19-vaccine-following-cdc-acip-meeting | 23:27 |
| Brainstorm | New from r/COVID19: COVID19: Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19 → https://www.reddit.com/r/COVID19/comments/ri1z3p/distinct_sarscov2_sensing_pathways_in_pdcs/ | 23:46 |
| friedrice | hard to get people to do 3rd shot, when everyone pretends there is no pandemic | 23:48 |
| friedrice | other than bad cloth masks , and some alcohol gel for hygeine theater | 23:49 |
| Brainstorm | New from r/COVID19: COVID19: Interaction of SARS-CoV-2 with cardiomyocytes: Insight into the underlying molecular mechanisms of cardiac injury and pharmacotherapy → https://www.reddit.com/r/COVID19/comments/ri23vo/interaction_of_sarscov2_with_cardiomyocytes/ | 23:55 |
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