| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Member of Bayer-Monsanto Admits that it’s a gene therapy → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/sj39pk/member_of_bayermonsanto_admits_that_its_a_gene/ | 00:24 |
|---|---|---|
| Brainstorm | New from The Lancet (Online): [Editorial] Managing the opioid crisis in North America and beyond: 2020 marked the deadliest year yet in the North American opioid epidemic: more than 100 000 drug overdoses were recorded in the USA, nearly 76 000 of them attributed to opioids, an increase [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00200-8/fulltext | 00:33 |
| Brainstorm | Updates for India: +164593 cases, +991 deaths since 17 hours ago — Canada: +10374 cases, +143 deaths since 17 hours ago — France: +321056 cases, +284 deaths since 17 hours ago — Germany: +67015 cases, +174 deaths since 17 hours ago | 00:37 |
| Brainstorm | Updates for Netherlands: +67114 cases, +13 deaths since 18 hours ago | 01:02 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Should We Go All In on Omicron Vaccines? theatlantic.com/science/archiv… → https://twitter.com/Marc_Veld/status/1489025021712506883 | 01:02 |
| LjL | <CarlSagan> [Ars Technica - Science] Tonga in lockdown after COVID spread from wharf workers https://arstechnica.com/?p=1831399 2022-02-02T22:59:23 | 01:45 |
| LjL | first community transmission :( | 01:45 |
| LjL | "How the five infections came about is still not completely clear. Tongan officials have insisted on contactless aid deliveries, with supplies being unloaded from ships and planes into quarantine areas where they are left isolated for 72 hours." | 01:46 |
| xx | because 'rona can remain viable on surfaces for longer than 72 hours | 01:47 |
| xx | we've known that for many decades, and this coronavirus is no exception | 01:47 |
| xx | I quarantine all my deliveries for a week first, and then sanitize them | 01:48 |
| LjL | lol, r/Coronavirus just auto-rejected my submission (of the above) because evidently Ars Technica doesn't cut it for them | 01:50 |
| LjL | sure it's not an academic paper, but, err, r/COVID19 is the one for academic paper | 01:50 |
| Dredd | I remember a discussion on doing that sort of thing in here before. I don't do any of that and just make sure to wash or sanitise my hands whenever I come in | 01:50 |
| Dredd | So far it's working well enough | 01:50 |
| LjL | r/Coronavirus's sidebar literally says "For scientific discussion of COVID see /r/COVID19" | 01:50 |
| Dredd | LjL @LjL:libera.chat: is Tonga the land of tinwhiskers? | 01:50 |
| LjL | Dredd, he's not been there for quite a while | 01:51 |
| xx | LjL: they just don't like you | 01:51 |
| Dredd | Oh he left? | 01:51 |
| LjL | xx, last time when my comments weren't showing up, they said the antispam trigger was being triggered somehow, and that they'd fix it | 01:51 |
| Dredd | I thought he owned a house there? | 01:51 |
| LjL | Dredd, he is a NZ citizen, and he's back there, very much for his luck given the tiny little volcano eruption and tsunami that almost certainly wiped out his house there | 01:52 |
| xx | pretty bad idea to own a house in a place that can cease to exist after a tsunami | 01:52 |
| LjL | Tonga has their first COVID cases now because of international aid bring brought in | 01:52 |
| LjL | xx, yeah, pretty dumb to be a Tokyoite | 01:52 |
| Dredd | Well I imagine it was pretty lightweight and easy to rebuild | 01:52 |
| LjL | too bad a substantial amount of world population lives in such places | 01:52 |
| LjL | including almost the entire US west coast | 01:53 |
| xx | LjL: oh I know how to solve that ;) | 01:53 |
| Dredd | There's a certain appeal to going to live in a tropical island... | 01:53 |
| LjL | xx, i dunno, i thought you'd think it's a good idea to live where a tsunami may make you cease living, anyway, especially if massive amounts of people do it | 01:53 |
| Dredd | Forget the world | 01:53 |
| LjL | i'm largely wasting away my life while living in a place that's boring as all fucks and the worst that happens is the stupid underground "river" flooding the northern part of the city when it pours | 01:54 |
| xx | LjL: nah, better to free up space in general so that those who remain can move to the places that don't have natural disasters | 01:54 |
| LjL | i suspect if i were willing and able to live in the wilderness, i may have a shorter but better life | 01:54 |
| xx | doesn't italy have earthquakes from time to time? | 01:54 |
| LjL | not here | 01:54 |
| LjL | unless you count the one a while ago that woke me up | 01:55 |
| LjL | which turned out to be a 3.5 or something | 01:55 |
| xx | well, that's still something, so not completely boring | 01:55 |
| LjL | a tiny earthquake every fifteen year | 01:55 |
| LjL | color me excited | 01:55 |
| * xx colors LjL excited | 01:55 | |
| LjL | %act like xx when excited | 01:56 |
| Brainstorm | LjL, I think xx would say: no, I still get a side of the things posted by the bot just get whatever vaccine you can also get tested on the main issue, I can't keep up to me. When I go outside, don't interact with humans" | 01:56 |
| xx | heh | 01:56 |
| xx | anyway I doubt we'll find the true source of the Tonga infection | 01:56 |
| xx | but my bet would be surfaces | 01:56 |
| * Tuvix discovers stacked timeline CDC visualization plots with logarithmic data-axis. This is so much more useful to stack values several orders of magnitude apart! | 01:56 | |
| LjL | xx, that seems possible but i wouldn't necessarily underestimate the power of wanting a tongan pub beer + bribery (or similar) | 01:57 |
| Dredd | Could be a random viron cast asunder to the wind | 01:57 |
| LjL | Tuvix, OWID does log (but, well, it doesn't do US states) | 01:58 |
| xx | or maybe it was dolphins or some other creature | 02:00 |
| xx | fishermen come into contact with all sorts of crazy species | 02:00 |
| LjL | Tuvix, here's another site with North America specific info and offering log graphs, it goes down by county | 02:00 |
| Tuvix | The trends match up quite well for lowest 4 age-groups, and the top-4: https://imgur.com/pgrt7d1 | 02:01 |
| Brainstorm | Updates for Switzerland: +27 deaths since 19 hours ago | 02:05 |
| Tuvix | Yup, I've used OWID too, depending on what I'm looking for | 02:06 |
| Brainstorm | New from COVID on Twitter: Curtis Kapsak (@CurtisKapsak): It's refreshing to listen to non-COVID science once in a whileTonight @florian_krammer presented "Does Anybody Remember Influenza?" at @EmoryUniversity Vaccine Dinner Club Thanks and great talk, Dr. Krammer! pic.twitter.com/BE3D7Xyc2J → https://twitter.com/CurtisKapsak/status/1489034512520654849 | 02:09 |
| xx | how is the flu season doing anyway? | 02:09 |
| LjL | xx, for comparison with previous years i only know of graphs showing "respiratory illnesses" in general and not narrowed down to influenza (which would depend on how much and what type of testing / sequencing is done each year). on https://www.cdc.gov/flu/weekly/index.htm you can find "Outpatient Respiratory Illness Visits" with comparisons down to 2017 (and 2009) and i guess it looks like an average year, although here in Italy at least, it's likely that the peak | 02:16 |
| LjL | was *not* due to flu but to RSV or something | 02:16 |
| xx | that's why I wasn't a big fan of them combining all the reporting into just "respiratory illness" instead of specifics | 02:17 |
| LjL | well it's because they don't know | 02:17 |
| LjL | they have specifics too | 02:17 |
| xx | it's because they don't want to know | 02:17 |
| LjL | that same page has specifics showing it's mostly influenza A | 02:18 |
| LjL | and which subtype of influena A in particular | 02:18 |
| LjL | however, that's the cases that were sequenced | 02:18 |
| LjL | so you can't just compare to other years | 02:18 |
| LjL | doesn't mean there is no such info | 02:18 |
| LjL | they've tested 490,190 people, it says. check how many people italy sequenced *sneer* | 02:18 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): 79% reduction of hospitalization compared to placebo for Novartis' DARPin antibody mimetic, similar to sotrovimab. Doesn't say % Omicron but in vitro it shows no loss of activity. This is the antibody mimetic protein furthest along in clinical [... want %more?] → https://twitter.com/michaelzlin/status/1489044157653913604 | 02:19 |
| Tuvix | aggregate data for all prior 10 years for flu is available (I've used the 10-year annual avearge of 36.9k in a few of my C19 vs influenza comparisons) | 02:19 |
| xx | italy probably tested less than a thousand, if I were to bet | 02:19 |
| xx | tested = find out what strain of flu it was | 02:19 |
| LjL | actually don't check, because the entire sub-website is down | 02:19 |
| Tuvix | That number is actually a bit inflated due to one especially bad year that saw over 60k deaths in the US alone from flu, but it still doesn't change the average comparison percentages much given that COVID is (and continues to, in the US anyway) take death at an order of magnitude greater. | 02:20 |
| xx | number of influenza infections should be a good indicator of the effectiveness of covid measures or people's adherence to those measures | 02:20 |
| Tuvix | CDC has some data on influenza strains IIRC. | 02:20 |
| xx | because covid measures should effectively prevent flu infections too | 02:21 |
| LjL | xx, 4721 tested in Italy so far | 02:21 |
| xx | and flu spreads harder than covid | 02:21 |
| Tuvix | Well, only to a point; a RAT or PCR test for COVID won't do anything to cut down on flu transmission if people who are (probably) COVID-19-negative go infect someone with seasonal flu. | 02:21 |
| xx | LjL: yeah I was wrong then, but at least in the ballpark | 02:21 |
| LjL | so about 1/100 of the testing in the US, despite having 1/5 of the population, eh | 02:21 |
| Tuvix | Same with people who may have gotten COVID-vaccines but not gotten a flu vaccine, although the flu vax this year was a bit of a miss for the prevailing strains in the Global North. | 02:22 |
| LjL | xx, i suspect the very low number of influenza infections in 20202 was mostly a good indicator of the effectiveness of covid measures *in asia* | 02:22 |
| LjL | the rest of us basically just didn't get it | 02:22 |
| LjL | we might have partied like no tomorrow but if the virus doesn't reach us... | 02:22 |
| Tuvix | Yea, you can compare the US data for flu here, and note that substantial difference this year vs. last year: https://www.cdc.gov/flu/weekly/usmap.htm | 02:23 |
| Tuvix | Oh, that may be a factor of COVID too, "This system monitors visits for respiratory illness that includes fever plus a cough or sore throat, also referred to as ILI, not laboratory confirmed influenza" | 02:24 |
| Tuvix | Still, that site puts the weekly tracking summary at 4.3/100k cumulative hospitalization rate. Our COVID _death_ rate is currently 4.99/100k (rolling 7-day average) by comparison. | 02:26 |
| Tuvix | 4.3/100k for influenza or ILI hosp, that is. | 02:26 |
| LjL | now that Brainstorm's numbers are back, since i'm too lazy to check anything else... | 02:27 |
| LjL | Italy's green pass system was supposedly praised | 02:27 |
| LjL | the UK's lack of any restrictions was booed | 02:27 |
| LjL | %cases italy | 02:28 |
| LjL | %cases uk | 02:28 |
| Brainstorm | LjL: Italy has had 11.2 million confirmed cases (18.7% of all people) and 147320 deaths (1.3% of cases; 1 in 409 people) as of 7 hours ago. 92.2 million tests were done (12.2% positive). 48.5 million were vaccinated (80.6%). See https://www.epicentro.iss.it/en/coronavirus/sars-cov-2-dashboard or https://lab24.ilsole24ore.com/coronavirus/en/ | 02:28 |
| Brainstorm | LjL: United Kingdom has had 17.6 million confirmed cases (26.5% of all people) and 157938 deaths (0.9% of cases; 1 in 421 people) as of 6 hours ago. 455.7 million tests were done (3.9% positive). 51.8 million were vaccinated (78.0%). See https://coronavirus.data.gov.uk/ | 02:28 |
| LjL | i don't look at the actual case count, as you can see the UK tests *a ton* more. but they currently have lower mortality rate (over the population) than Italy | 02:28 |
| LjL | even after their Delta wave never really stopped | 02:28 |
| LjL | (just turned into Omicron) | 02:28 |
| Brainstorm | New from COVID on Twitter: (((Howard Forman))) (@thehowie): “Our approach is to not use a nasal vaccine as a primary vaccination, but to boost with nasal vaccine, because then you can leverage the existing immunity that’s already created,” @VirusesImmunity twitter.com/nytimes/status… → https://twitter.com/thehowie/status/1489045644140556289 | 02:38 |
| Tuvix | UK isn't all that far behind Italy though; pre-Delta, the US was actually doing better for pandemic-total death rates compared to the UK. | 02:45 |
| Tuvix | That changed when the US lost any hope of controlling surges starting with Delta. | 02:45 |
| LjL | it isn't far behind but you'd expect it to be much worse, from a certain perspective | 02:46 |
| Tuvix | The first 2 JHU case-charts only plot the top-10 countries (in raw value total deaths) but there are exactly 2 countries that, starting around delta, have quickly passed most of their nearby "competition" in per-capita deaths rates: https://coronavirus.jhu.edu/data/cumulative-cases) | 02:46 |
| Tuvix | Those 2 countries are the US, and Russia. | 02:46 |
| Brainstorm | New from Reddit (test): Covid2019: Omicron Reinfection Found With New BA.2 Strain In Israel - I24NEWS → https://old.reddit.com/r/Covid2019/comments/sj6cs8/omicron_reinfection_found_with_new_ba2_strain_in/ | 02:48 |
| LjL | Tuvix, then i suggest those country distract the population from the COVID issue with, i dunno, a war or something | 02:51 |
| Tuvix | Well, "technically" the US is only moving troops around the globe to support NATO allies, but yea, the situation and grandstanding is not great. | 02:52 |
| Tuvix | Both sides are being stupid in that situation, and as you point out they both have plenty of domestic issues at home. | 02:53 |
| Brainstorm | Updates for Guadeloupe: +8647 cases since 20 hours ago | 03:09 |
| LjL | %title https://twitter.com/michaelmina_lab/status/1488988413948829696 | 03:16 |
| Brainstorm | LjL: From twitter.com: Michael Mina (@michaelmina_lab): "1/ @CDCgov exit isolation at day 5 w/out Neg Rapid Ag Test = dangerous policy Important New Research We followed 260 Health Care Workers returning to work early • [...] | 03:16 |
| LjL | ... "**Positivity 2x-3x HIGHER if Boosted**" | 03:16 |
| LjL | so it may be even more stupid to relax rules for positive people who are boosted | 03:16 |
| LjL | as they are the most likely to still be infectious after day 5 | 03:16 |
| LjL | if we don't have enough tests, let's please just make more tests, instead of bending the rules and making them dumb | 03:17 |
| Tuvix | Messaging has been just broken for double-digit months now. The CDC, largely at the administration's behest, has put all their eggs in the vaccination basket, but we know how much reduction measures like tests and masks really make a difference now, scientifically. | 03:18 |
| Tuvix | The problem is that once you open that pandora's box, it's hard to close it | 03:18 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): More than 3,300 lost American lives reported today, with a 7-day average over 2,600 and still ascending. Nearly all preventable. The US pandemic peak of 3,300 avg was in early January before vaccines were availableUS is 79% peak c/w UK 21%, Spain 30%, and many [... want %more?] → https://twitter.com/EricTopol/status/1489066665752944641 | 03:45 |
| Brainstorm | Updates for Germany: +67232 cases since 20 hours ago | 03:59 |
| Brainstorm | New from COVID on Twitter: Josiah 'So Mild' Grindrod (@JT_Grindrod): Bats can carry a lot of viruses and be generally unbothered by them. They happily "live with" SARS, Marburg, Ebola, and many more, we probably haven't discovered many of them.Unfortunately, we are not bats.But look how cute these guys are [... want %more?] → https://twitter.com/JT_Grindrod/status/1489070958308515840 | 04:05 |
| LjL | wow, they actually did a human challenge study in the end | 04:15 |
| LjL | %title https://www.researchsquare.com/article/rs-1121993/v1 | 04:15 |
| Brainstorm | LjL: From www.researchsquare.com: Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge | Research Square | 04:15 |
| LjL | this comment on it caught my attention https://np.reddit.com/r/Coronavirus/comments/siq5cd/exposure_to_one_nasal_droplet_enough_for_covid/hvbl251/ | 04:16 |
| LjL | also, the finding that people develop symptoms after 2 days isn't consistent with what i knew, although the peak infectiousness being at 5 days is | 04:17 |
| Brainstorm | New from ##covid-19 Zotero group: Exposure to one nasal droplet enough for Covid infection – study: Type Forum Post Author stickingitout_al URL www.reddit.com/r/Coronavirus/comments/siq5cd/exposure_to_one_nasal_droplet_enough_for_covid/ Date 2022-02-02T14:34:11.000Z Accessed 2022-02-03 03:18:37 Post Type Reddit [... want %more?] → https://www.zotero.org/groups/covid_links/items/QFECJZGA | 04:24 |
| Brainstorm | New from Reddit (test): China_Flu: Low Dose Naltrexone (LDN) - Mechanism of Action (Dr. Syed) → https://old.reddit.com/r/China_Flu/comments/sj8wdj/low_dose_naltrexone_ldn_mechanism_of_action_dr/ | 04:43 |
| Tuvix | To put Topol's accurate statemnet about US death rate in another context, JHU's 2529 7-day average deaths is about one 9/11 size death event in terms of lives lost every 28 hours or so; almost all of these are avoidable :\ | 04:45 |
| Tuvix | While I realize the death rate will fall after the worst of the Omicron impact is over, this current week's rate of death is equal to three-hundred eight twin-towers loss of life. That's just insane. | 04:47 |
| Tuvix | Erm, I didn't finish that thought properly; 308 twin-towers per *year*, at the current rate of COVID-19 deaths. | 04:57 |
| Brainstorm | Updates for United Kingdom: +87682 cases since 22 hours ago — Netherlands: +67217 cases since 22 hours ago | 05:02 |
| Brainstorm | Updates for Belgium: +45428 cases, +49 deaths since 23 hours ago — India: +172433 cases, +1752628 tests (0.4% positive) since 23 hours ago — Canada: +180 deaths since 23 hours ago | 06:04 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Protecting People with Cancer from COVID-19: New Recommendations from Cancer Guidelines Organization - The National Comprehensive Cancer Network (NCCN) → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/sjb1gf/protecting_people_with_cancer_from_covid19_new/ | 06:37 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Unrelated vaccines could also help reduce the burden of COVID-19 pandemic, study shows: "This modeling study shows the potential power of all vaccines in keeping the immunological system primed and healthy, → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/sjb94h/unrelated_vaccines_could_also_help_reduce_the/ | 06:47 |
| Brainstorm | Updates for Germany: +230975 cases since 15 hours ago — Piaui, Brazil: +2117 cases, +7 deaths since a day ago — Prince Edward Island, Canada: +600 cases, +1 deaths since a day ago — Newfoundland and Labrador, Canada: +248 cases, +4 deaths since a day ago | 07:07 |
| Brainstorm | New from BMJ: Data must underpin our response to the covid-19 pandemic’s disastrous impact on cancer: One consequence of the global response to the covid-19 pandemic has been the disruption it has caused to health services and for patients with non-communicable diseases. We have previously... → http://www.bmj.com/content/376/bmj.o282.short | 07:53 |
| jbwncster | https://www.usatoday.com/story/news/health/2022/02/02/covid-cases-mandates-vaccines-deaths/9308759002/ | 08:24 |
| Brainstorm | New from MedicineNet: (news): Pfizer Seeks Approval for COVID Vaccine for Kids Under 5 → http://www.medicinenet.com/script/main/art.asp | 08:41 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | February 03, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/sjdm32/daily_discussion_thread_february_03_2022/ | 09:09 |
| Brainstorm | New from r/WorldNews: worldnews: Scandinavia to become almost entirely free of COVID restrictions - with Sweden to join Denmark and Norway in scrapping rules → https://old.reddit.com/r/worldnews/comments/sjdsrv/scandinavia_to_become_almost_entirely_free_of/ | 09:29 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): As normal good piece at Financial Times on BA.2 explained: the Omicron sub-variant outpacing its predecessor - on.ft.com/3IXt2dw → https://twitter.com/Tuliodna/status/1489158537808863233 | 09:57 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): January 2022: a year after vaccine roll out; yet 66% of those in ICU in NL is still not vaccinated! pic.twitter.com/VorMOC0Ht5 → https://twitter.com/Marc_Veld/status/1489162318822924291 | 10:07 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): ‘Scientist speculates that BA.1 Omicron caught an earlier flight out of South Africa, where both strains were first identified’ This accusations is what stop countries releasing epidemic data. First travel bans & after speculations. Shame @ScienceMagazine [... want %more?] → https://twitter.com/Tuliodna/status/1489165785918590979 | 10:26 |
| Brainstorm | New from r/Science: science: A new study confirms what many in the disabled community already know: People with disabilities have been experiencing high levels of depression and anxiety during the Covid-19 pandemic. Stigma was also a major predictor for depression and anxiety, [... want %more?] → https://old.reddit.com/r/science/comments/sjf23d/a_new_study_confirms_what_many_in_the_disabled/ | 11:04 |
| Brainstorm | New from BBC Health: NHS Tracker: How is the NHS in your area coping this winter?: Winter and Covid are putting the NHS under severe strain, find out what's happening in your area. → https://www.bbc.co.uk/news/health-59549800 | 11:23 |
| Brainstorm | New from BMJ: Tom Nolan’s research reviews—3 February 2022: Ventilators on displayWe’ve probably reached the stage of the pandemic where someone, somewhere, must be dreaming up plans for a national covid-19 museum. I, for one, can’t wait to take the kids to... → http://www.bmj.com/content/376/bmj.o262.short | 11:43 |
| darsie | Now 3/6 ppl in our shared flat are positiv. | 11:59 |
| Brainstorm | Updates for Kiribati: +146 cases since 23 hours ago | 12:00 |
| Brainstorm | New from ECDC: Data on COVID-19 vaccination in the EU/EEA: Data in various file formats with information on COVID-19 vaccine doses administered, manufacturers, and target groups in the EU/EEA. → https://www.ecdc.europa.eu/en/publications-data/data-covid-19-vaccination-eu-eea | 12:03 |
| undefined_bob | darsie: why not more? | 12:31 |
| darsie | Because we're careful. | 12:31 |
| darsie | or because we live in the present. | 12:31 |
| undefined_bob | oki, hopefully the others wont get infected too | 12:31 |
| Brainstorm | New from ECDC: ECDC: Data for the maps in support of the Council Recommendation on a coordinated approach to the restriction of free movement in response to the COVID-19 pandemic in the EU/EEA → https://www.ecdc.europa.eu/en/publications-data/indicators-maps-support-council-recommendation | 12:42 |
| darsie | I'm a bit worried because I'm on hunger strike. Might be a bad combination with covid. | 12:44 |
| trbp | why are you hunger striking? | 12:55 |
| trbp | and i would not advise beeing ill with any strike | 12:55 |
| trbp | let it be hungering around | 12:56 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): "Viruses don’t inevitably evolve toward being less virulent; evolution simply selects those that excel at multiplying. In the case of Covid-19,in which the vast majority of transmission occurs before disease becomes severe,reduced severity may not be [... want %more?] → https://twitter.com/GANyborg/status/1489208987144929283 | 13:11 |
| darsie | trbp: I'm hunger striking against anthropogenic mass extinction of species, which is caused by climate change and other stupidity. | 13:31 |
| trbp | speaking of stupidity, t | 13:34 |
| trbp | he last consequence of hunger strike is death | 13:35 |
| trbp | correct? | 13:35 |
| trbp | so how have any impact if any? (as we know some things cannot be changed in the bigger picture by one alone even if dead) | 13:35 |
| trbp | after beeing dead? | 13:35 |
| trbp | i would rethink that striking strategy | 13:35 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 03FEB22 → https://old.reddit.com/r/nCoV/comments/sji3lt/global_covid_cases_for_03feb22/ | 13:40 |
| Brainstorm | New from COVID on Twitter: Covid Fact Check UK (@fact_covid): The UK regulator @MHRAgovuk has finally approved the @Novavax COVID-19 vaccine - the fifth to be authorised for use in this country.gov.uk/government/new… → https://twitter.com/fact_covid/status/1489220914915037185 | 13:59 |
| Brainstorm | Updates for Palau: +175 cases, +663 tests (26.4% positive) since 22 hours ago | 14:05 |
| Brainstorm | New from StatNews: STAT+: Such a deal! Covid-19 therapies appear cost-effective…for now: Prices charged for several Covid-19 medicines, including those from Pfizer and Merck, are reasonably priced based on the value they offer patients, according to a preliminary assessment. → https://www.statnews.com/pharmalot/2022/02/03/such-a-deal-covid-19-therapies-appear-cost-effective-for-now/ | 14:09 |
| de-facto | darsie, wear a FFP2/3 mask and drink green tea in small sips over whole day and insist that windows are opened | 14:10 |
| de-facto | that way i prevented myself from getting infected when a household member tested positive some time ago | 14:11 |
| de-facto | sanitize door knobs etc with ethanol and frequently wash hands with warm water and soap | 14:11 |
| lastshell | hi guys I saw that the new subvariant of omicron can maybe re-infect previous omicron infected people ? | 14:12 |
| lastshell | is fear mongering or is true ? | 14:12 |
| de-facto | which one? | 14:12 |
| lastshell | B2 I think | 14:12 |
| de-facto | you should investigate UK and Denmark datasets i guess | 14:13 |
| lastshell | also the free masks that US goverment is giving are n95 masks but is like an open product | 14:13 |
| lastshell | no sealed packages | 14:13 |
| lastshell | they use there hands to hand it over I want to sanitize | 14:14 |
| de-facto | hmm here they are inside transparent sealed plastic bags | 14:14 |
| lastshell | no | 14:14 |
| lastshell | well at least that was not my case | 14:14 |
| de-facto | dont sanitize masks it damages their elestrostatic polypropylene fibers | 14:14 |
| lastshell | I hear sun exposure help de-facto ? | 14:15 |
| de-facto | no heat, no alcohol etc | 14:15 |
| de-facto | UV light yeah, not sure how that affects filter capabilities | 14:15 |
| de-facto | but definitely dont use alcohol, water, heat etc those are known to destroy the filter | 14:16 |
| lastshell | thanks | 14:16 |
| de-facto | i just hang my masks and let them dry for a few days, then reuse | 14:17 |
| lastshell | de-facto u are in US or other country I forgot | 14:17 |
| de-facto | im in Germany | 14:17 |
| lastshell | I feel after omicron I got some memory fog effect | 14:18 |
| de-facto | yeah many say that, just give it some time | 14:19 |
| Brainstorm | New from COVID on Twitter: PhenoPlasm (@PhenoPlasm): New machine-learning approach to try to fill in both the portion of phenotypes missed in last couple of years of pandemic, and found quite a few from long before. Sadly still far from fully automated. pic.twitter.com/D2clRmUWkJ → https://twitter.com/PhenoPlasm/status/1489225005242236932 | 14:19 |
| de-facto | maybe eat good foods and train your brain, e.g. do Sudoku or such :) | 14:20 |
| lastshell | thanks | 14:22 |
| de-facto | i also take Ginkgo and B-vitamins (among other things) | 14:22 |
| de-facto | we have to make the best out of those times... | 14:23 |
| xx | de-facto: isopropylalcohol does not destroy the electrostaticness of the polypropylene fibers after it dries | 14:50 |
| xx | it can be sprayed onto those masks | 14:50 |
| xx | of course it can't be done forever, but it can prolong the lifetime of the filters if you are in a situation where you can't replace them | 14:51 |
| Brainstorm | New from WHO Euro: Cancer services disrupted by up to 50% in all countries reporting: a deadly impact of COVID-19: The European Region has recorded 12 million new [COVID-19] cases in the past week. This is [... want %more?] → https://www.euro.who.int/en/media-centre/sections/statements/2022/statement-cancer-services-disrupted-by-up-to-50-in-all-countries-reporting-a-deadly-impact-of-covid-19 | 14:58 |
| Brainstorm | Updates for Switzerland: +36568 cases, +25 deaths, +104174 tests (26.0% positive) since 23 hours ago — Germany: +238032 cases since 23 hours ago | 15:08 |
| Dredd | My brother's positive covid LFTs have been confirmed by a PCR result now | 15:25 |
| Dredd | Still not feeling too bad though so that's good | 15:25 |
| Brainstorm | New from COVID on Twitter: Joe Pickrell (@joe_pickrell): Interesting article: "scientists have been looking for the source of strange coronavirus sequences that have appeared in the city’s wastewater." nytimes.com/2022/02/03/hea… → https://twitter.com/joe_pickrell/status/1489240819496206336 | 15:26 |
| Dredd | The above link is an interesting read | 15:34 |
| Dredd | Mystery covids maybe from animals | 15:34 |
| Brainstorm | New from StatNews: STAT+: Pharmalittle: Former Rochester CEO is convicted over opioid crisis; Covid-19 therapies appear cost-effective: The prices charged for several medicines used to treat people with mild-to-moderate Covid-19 are reasonably priced based on the value they [... want %more?] → https://www.statnews.com/pharmalot/2022/02/03/covid19-opioid-crisis-hiv-aids-alzheimers-cannabis/ | 15:36 |
| Brainstorm | New from COVID on Twitter: Prof. Shane Crotty (@profshanecrotty): Almost 4,000 Americans died from COVID-19 on Tuesday. covid.cdc.gov/covid-data-tra… → https://twitter.com/profshanecrotty/status/1489251724246151176 | 16:06 |
| Dredd | Tuvix: another day of 4k deaths ☹️ | 16:08 |
| Brainstorm | Updates for Canada: +11550 cases, +107 deaths since 23 hours ago | 16:10 |
| Brainstorm | New from COVID on Twitter: Prof. Shane Crotty (@profshanecrotty): Excellent article on COVID-19 immunity. With excellent insights by @EJohnWherry @TheBcellArtist @MarkSlifka Rafi Ahmed and @DonnaFarber3 . Lots of good immunology in this one. :)nature.com/articles/d4158… → https://twitter.com/profshanecrotty/status/1489255056431980550 | 16:16 |
| xx | Dredd: how many americans are left? | 16:24 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The countries that will not reach 70% 2-shot vaccinated by mid-2022. One is the 3rd largest in population and among the richest in the world twitter.com/redouad/status… → https://twitter.com/EricTopol/status/1489257678320795654 | 16:25 |
| Dredd | xx: eleventy-four | 16:26 |
| Dredd | 😉 | 16:26 |
| xx | sounds like at this rate it will take a loooong time for the lands of USA to return to wilderness | 16:27 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Check out @tylernstarr's excellent summary of the final version of our study showing that ACE2-binding is an ancestral trait of SARS-related CoVs that extends to viruses from outside southeast Asia. twitter.com/tylernstarr/st… → https://twitter.com/jbloom_lab/status/1489259775581831175 | 16:35 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): "Preprints on the coronavirus have been impressively reliable"economist.com/science-and-te… @TheEconomist "These findings support ...“open science”, who say that new scientific results should be made available to other researchers and the public freely and quickly." → https://twitter.com/EricTopol/status/1489262385365852169 | 16:45 |
| lastshell | Dreed in where the 4k in us ? | 16:54 |
| lastshell | *dredd | 16:54 |
| Brainstorm | New from COVID on Twitter: Josiah 'So Mild' Grindrod (@JT_Grindrod): Can someone tattoo this tweet on the back of every policy maker's hand so they have to stare at it every day?If you think Omicron is the end you live in a fairy tale world. twitter.com/GuptaR_lab/sta… → https://twitter.com/JT_Grindrod/status/1489264896038424581 | 16:55 |
| Brainstorm | Updates for United Kingdom: +87833 cases since 21 hours ago | 17:00 |
| pwr22 | lastshell: it was one of the Brainstorm links | 17:01 |
| Brainstorm | New from ClinicalTrials.gov: (news): Treatment of Non-Severe COVID-19 Outpatients With Xagrotin, Phase 3 → https://clinicaltrials.gov/ct2/show/NCT05222425 | 17:05 |
| -Bridgestorm- 🏠 Temblor! Sismo! Earthquake! 6.0 Mw tremor, registered by EMSC,alomax, with 8 reports, 1 early, occurred 20 minutes ago (15:58:57 UTC), during daytime, Northern Peru (-4.43, -76.75) ± 3 km, ↓54 km likely felt 370 km away (in Moyobamba, Tarapoto, Chachapoyas…) by 317100 people (alomax.free.fr) | 17:19 | |
| Klinda | here in Italy there are 400 deaths each day and now seems no one care about it, it's like we did all and that's it | 17:38 |
| pwr22 | Seems similar in a lot of places around the world | 17:40 |
| pwr22 | It's become "normal" | 17:40 |
| ecks | will be interesting to see excess mortality during the omicron wave | 17:45 |
| xx | Klinda: didn't italy stop some restrictions today? | 17:49 |
| Klinda | no they did more restriction of green pass, now also in normal shops all have to ask for it | 17:50 |
| Brainstorm | Updates for Netherlands: +83119 cases, +10 deaths since 23 hours ago | 18:03 |
| Brainstorm | New from COVID on Twitter: Scott Lincicome (@scottlincicome): "The Burden of 1 Million Excess Deaths: 13.5 Million Years of Life Lost During the COVID Pandemic" healthpolicy.usc.edu/evidence-base/… pic.twitter.com/3WIp7lTutz → https://twitter.com/scottlincicome/status/1489283895287857157 | 18:14 |
| xx | 1 million excess new empty places to buy/rent (but likely already bought out by large companies) | 18:16 |
| Tuvix | xx: Do *NOT* use isopropyl alcohol on masks: Using soap and water or medical grade alcohol significantly decreases the FE of the masks (54% and 67%, respectively) (ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161499/ ) | 18:16 |
| xx | Tuvix: they are wrong, I have info from 3M the manufacturer on disinfection practices of reusable masks | 18:17 |
| xx | and that study doesn't even mention IPA | 18:18 |
| pwr22 | They are presumably meant to be re-used vs whatever was in that paper? | 18:18 |
| Tuvix | xx: "medical grade alcohol" is IPA. | 18:19 |
| Tuvix | FFS. | 18:19 |
| xx | no way, really? | 18:19 |
| xx | that's stupid | 18:19 |
| Tuvix | Soruce please on your claim? | 18:19 |
| pwr22 | Tuvix: what's FE? I would have guessed soap would have been the worse one given it's a surfactant and doesn't fully evaporate like alcohol | 18:19 |
| xx | pwr22: filtration efficiency | 18:20 |
| Tuvix | The NIH link I provided gives a source on the tests they provided, so while it's possible that a _specific_ mask has been designed around a different decontamination procedure for re-use, I would be beyond careful giving such "general" advice to the channel here as if it's fact before doing due dilligence on the research. | 18:20 |
| pwr22 | Filtering efficiency yeah | 18:20 |
| LjL-Matrix | Utter idiocy (to not have thought about this before) https://www.reuters.com/world/europe/eu-ease-rules-covid-pass-remove-hurdle-vaccine-trials-2022-02-03/ | 18:21 |
| Tuvix | The isseue is that most alcohols strong enough to decontaminate the mask also greatly reduce the electrostatic charge; high-filtration filters rely very heavily on this, which is why studies like the one out of the Tennessee, are so important using commonly available filters. | 18:22 |
| pwr22 | The citation for that claim on FE degradation is this https://utrf.tennessee.edu/information-faqs-charged-filtration-material-performance-after-various-sterilization-techniques/ | 18:23 |
| pwr22 | It now says it doesn't have the FAQ and you should go to https://www.n95decon.org/ instead | 18:23 |
| Brainstorm | New from StatNews: Biotech: STAT+: Eleven years after buying Genzyme, Sanofi officially ditches subsidiary’s storied name → https://www.statnews.com/2022/02/03/sanofi-genzyme-boston-name/ | 18:23 |
| Tuvix | Provided your goal is to kill SARS-CoV2, really a medical vaporized chamber is your only good options, and that may still have a partial impact on FE & fit, according to a chart with plenty of references supplied: https://static1.squarespace.com/static/5e8126f89327941b9453eeef/t/5ffe0c426639ea757c0ee5e7/1610484802173/20200816_N95_Decontamination_Reuse_Comparison_Matrix.pdf | 18:24 |
| pwr22 | https://static1.squarespace.com/static/5e8126f89327941b9453eeef/t/5f3b710423d0af47094d5e8c/1597731076752/200817_N95DECON_cautionsheet_v1_4_final.pdf | 18:24 |
| pwr22 | That's the bad methods | 18:24 |
| pwr22 | > Application of alcohols such as isopropanol or ethanol has been shown to | 18:25 |
| pwr22 | degrade the filtration efficiency of at least one N95 model. | 18:25 |
| pwr22 | The citations for that aren't easy to get at | 18:25 |
| pwr22 | So we may need better sources 😀 | 18:26 |
| pwr22 | LjL: so the EU is continuing it's strategy of being slow at vaccine stuff? | 18:26 |
| pwr22 | Will it soon also get cross at the UK again if we buy all the early Omicron vaccine doses? | 18:27 |
| pwr22 | Also silly EU for the technically incompetent cookie law that just results in annoying banners | 18:27 |
| pwr22 | and does nothing to stop tracking | 18:27 |
| Tuvix | https://www.n95decon.org/publications#caution | 18:28 |
| Tuvix | Oh, yea, that leads to the caution quote you cited in the summary PDF, although it's got 2 citations from 2007 and 2017. | 18:29 |
| xx | yeah they are crazy, they are actually submerging it in IPA | 18:30 |
| xx | instead of just spraying it onto it | 18:30 |
| Tuvix | Still, the fact that nearly all the N95 filters I'm aware of rely on multiple layers of specifically charged filtration material would make any of those a concern unless specifically designed for it. | 18:30 |
| pwr22 | Why does that matrix of decon techniques say that ozone needs chemical residue removed | 18:30 |
| pwr22 | I tend to just keep a mask in my pocket and reuse it for a week then throw it out (and it's just a surgical mask - not N95) | 18:31 |
| pwr22 | I have an ozone generator so maybe I should stick my mask in a box with it for 15 minutes each night | 18:31 |
| xx | well surgical masks are almost pointless but better than nothing I guess | 18:32 |
| xx | also far too costly in comparison to other methods | 18:32 |
| Tuvix | xx: Stop the bullshit please. DId you even READ the 2 citations linked? | 18:32 |
| Tuvix | Let me answer that for you. No, No you did not. "It was also found that decontamination using an autoclave, 160°C dry heat, 70% isopropyl alcohol, and soap and water (20-min soak) caused significant degradation to filtration efficiency." citation: Viscusi et al., 2007 | 18:33 |
| xx | Tuvix: I did | 18:33 |
| Tuvix | The "soak" as for soap and water, since that's how you use soap and water to clean a product. | 18:33 |
| Tuvix | An autoclave is not a "soak." | 18:33 |
| xx | "IPA * 10 min submersion in 100% isopropanol solution." | 18:33 |
| xx | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638397/ | 18:33 |
| xx | did you even read it? | 18:33 |
| Tuvix | Not the study I I just quoted. | 18:33 |
| xx | that study links to this one | 18:34 |
| Tuvix | I quoted Viscusi et al., 2007. | 18:34 |
| xx | or at least the studies eventually lead to studies that actually performed the tests | 18:34 |
| pwr22 | xx: xx: most people in the UK either have no masks or cotton single layer masks | 18:34 |
| xx | most other studies are just overviews of what has been done previously | 18:34 |
| pwr22 | So surgical masks are definitely going to work out better | 18:34 |
| Tuvix | They used an autoclave. | 18:34 |
| pwr22 | Especially in aggregate but yeah for my own protection they probably aren't great | 18:34 |
| xx | pwr22: it's been over 2 years, if they don't have masks now, it's on them | 18:35 |
| pwr22 | So probably no point with the effort | 18:35 |
| pwr22 | After all, it seems to have worked out so far for 2 years without me getting covid 🤷 | 18:35 |
| xx | that's survivor bias | 18:36 |
| pwr22 | But it means I'm a survivor 🤔 | 18:37 |
| pwr22 | eye of the tiger begins to play | 18:37 |
| pwr22 | There seems to be only a single paper or two that shows IPA harming masks and I bet there are others that show them not doing it. Which could be differences in masks, the techniques they used, the tests they are doing after. It just doesn't seem like enough data to me. There's usually a few papers on either side of any theory with evidence but it's usually clearer when you'd got like 70 good ones in favour and 3 bad ones ha ha | 18:38 |
| pwr22 | Seems xx has some M3 docs somewhere that lists disinfecting with IPA as a recommended approach and I guess that means for those masks its a good way to do it | 18:39 |
| xx | pwr22: it's email communication with 3m from the start of the pandemic | 18:39 |
| xx | of course ideally one would not have to reuse it, but in case there's no other option then disinfecting them is an option (though a poor one) | 18:40 |
| xx | like on the one hand people are fine reusing valveless reusable filters that get soaked from breath, and on the other hand people are against spraying the outside with IPA? | 18:40 |
| xx | I wouldn't spray it 20 times, but two or three times should still be fine, only losing 10%-20% efficiency compared to new | 18:41 |
| xx | which is still better than not having any PPE at all | 18:42 |
| xx | but of course putting that stuff in boiling water, or soaking it with ethanol or IPA for an hour, or any of the other crazy ideas is... crazy | 18:43 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The Omicron BA.2 wave in DenmarkICU admissions are declining, but not much else@OurWorldInData pic.twitter.com/f7BpUQDER7 → https://twitter.com/EricTopol/status/1489291688770105344 | 18:43 |
| LjL | pwr22, i have my qualms with the GDPR but i don't think it's utterly incompetent, and it's far more than just a cookie law... sure, sites try to make it as user-unfriendly as legally allowed by making the banners huge and making the buttons have obscure description, and the law could regulate that batter, but in fact some national implementations of the law *have* ruled such banners unlawful | 18:44 |
| LjL | pwr22, the EU already optioned a number of Omicron-specific vaccines from Pfizer or BNT | 18:45 |
| pwr22 | xx: since it's from the start of the pandemic it could be perhaps that it was just something they sent out without actual good testing? Or rather that maybe the tests they did were not comparable to the way the masks interact with coronavirus particles? | 18:45 |
| pwr22 | I would think that if it was still considered a good practice that we should be able to find some public docs from 3M on it | 18:45 |
| xx | pwr22: it was at the time when there was an actual lack of PPE, so it was sent out as a "last resort" what to do | 18:46 |
| xx | with a disclaimer that replacing is always better | 18:46 |
| xx | 3M had these tests for many years already, flu existed before covid | 18:47 |
| Tuvix | [citation needed] | 18:47 |
| Tuvix | (which is what we're asking for._) | 18:47 |
| Tuvix | If the tests exist, surely you can supply them? If not, how do you know they exist? What conditions were they tested? Did the filtration tests performed include the worst-case particle size capture? Under what conditions were they performed? | 18:48 |
| xx | "iif [sic] not possible to replace then spraying with IPA is an option to disinfect all the respirator types you ordered" - citation from the email | 18:48 |
| Tuvix | What is the impact of repeated application? How sensistive is the application method to changes in the performance by end-users? | 18:48 |
| pwr22 | I have found this: https://multimedia.3m.com/mws/media/1824869O/decontamination-methods-for-3m-filtering-facepiece-respirators-technical-bulletin.pdf | 18:48 |
| xx | pwr22: that's for the better masks | 18:49 |
| pwr22 | > 3M does not recommend decontaminating filtering facepiece respirators (FFRs). FFRs are designed to be discarded at the | 18:49 |
| pwr22 | end of their useful life and decontaminating FFRs may void the regulatory approval. | 18:49 |
| Tuvix | So, in other words, that "email" answers none of my questions, and should not be treatd as any authority to *avoid* causing severe damage to the mask. | 18:49 |
| pwr22 | Which masks are we talking about specifically because that's the only bulletin they had for N95 masks | 18:49 |
| Tuvix | Anying reading along or looking at the logs later should NOT assume that ANY testing was done on the method suggested in the email, becuase none apparently was. | 18:50 |
| xx | it was a reply to the question of if we have to choose between not wearing any mask at all, or disinfecting them | 18:50 |
| pwr22 | Yeah disinfection should win for sure | 18:50 |
| pwr22 | At least that makes them "safe" if not less effective | 18:50 |
| Tuvix | Re-use involves leaving them alone to dry out for a while; it's not generally recommended to disinfect since there is no approved method to do so that is easily accessible to home-users without costly medical grade equipment. At least not that's undergone studies, unless I've missed one. | 18:51 |
| xx | spraying IPA onto outside of the mask will kill any coronavirus on the surface of the mask, while only damaging the first layer of the mask. | 18:51 |
| Tuvix | Again, what citation do you hvae for this? | 18:51 |
| xx | water is wet, need a citation too? | 18:52 |
| xx | have you ever handled IPA? | 18:52 |
| Tuvix | You are being quite rude and hostile. | 18:52 |
| Tuvix | My goodness. | 18:52 |
| Tuvix | I'm about FE, and that is not something you can evaluate without medical grade equipment. | 18:53 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): And Novavax was approved in UK and Germany today. Besides a potentially broader antibody response, Novavax has the advantage of being stable in the refrigerator, so should be easier to distribute as well (important for outside US and [... want %more?] → https://twitter.com/michaelzlin/status/1489293426071728130 | 18:53 |
| xx | yeah, and I'm saying FE will be negatively affected by disinfection, but it is still better than not wearing a mask at all | 18:53 |
| xx | so you're just being combative for no reason, because we essentially agree | 18:54 |
| ublx | surely just leaving the mask unworn for several days is better than actively disinfecting it | 18:54 |
| Tuvix | No, I *DO NOT agree. | 18:54 |
| Tuvix | ublx: Yes, I agree with that statement. | 18:54 |
| xx | ublx: yeah, but this was during the time when that wasn't an option | 18:54 |
| xx | sure, putting it away in a safe place and rotating masks is great | 18:55 |
| pwr22 | rotate masks so each one has a week to disinfect before reuse > spraying ipa on mask in an emergency because you need it soon > no mask | 19:02 |
| pwr22 | I think this is what we would all agree? | 19:02 |
| Brainstorm | New from Contagion Live: us: Public Health Watch: Study Identifies 4 Key Risk Factors for Long COVID → https://www.contagionlive.com/view/public-health-watch-study-identifies-4-key-risk-factors-for-long-covid | 19:03 |
| Tuvix | "The scientists found that ethanol spray damaged the integrity of the respirator’s fit and seal after two decontamination sessions and therefore do not recommend it for decontaminating N95 respirators." (https://www.nih.gov/news-events/news-releases/nih-study-validates-decontamination-methods-re-use-n95-respirators) I'll have further quotes from the 19-page study shortly. | 19:03 |
| xx | ethanol is not IPA | 19:03 |
| xx | and pure ethanol is hard to get anyway for the regular person | 19:04 |
| xx | we need to get all sorts of certifications when we want to transport it | 19:04 |
| xx | (but that's just due to tax purposes) | 19:04 |
| pwr22 | ethanol and IPA will likely behave extremely similarly in terms of disinfecting a mask | 19:05 |
| Brainstorm | Updates for Italy: +112956 cases, +414 deaths, +915337 tests (12.3% positive) since 23 hours ago | 19:05 |
| Tuvix | Part of the other problem is that even with medical-grade equipment, feasibility in a professional healthcare setting is troublesome at best. Even with manufacturer / NIOSH instructions produces a large rate of errors (MT Bessesen et al. 2015, https://www.ajicjournal.org/article/S0196-6553(15)00089-9/fulltext | 19:10 |
| Tuvix | This is likely just as crucial has having an accepted and tested method with a standard that ensures effectiveness is not compromised. Any readers here or reading backlog should remain aware that any method without such testing and performed exactly as stated is likely to reduce the filter quality, possibly by enough to make the N95 no better than other options (depending on damage caused by repeat | 19:13 |
| Tuvix | application and the impact it has. | 19:13 |
| Tuvix | Now ironically, UV (accessible to most of us in the form of sunlight) is perhaps a better option, although it kills virus more slowly (Fischer, Morris, Doremalen, et. al) | 19:16 |
| Tuvix | This is intended for a summary for reuse options in medical-grade settings (hence the rather short re-use recommdnation,) but, "Our results indicate that N95 respirators can be decontaminated and re-used in times of shortage for up to three times for UV and HPV, and up to two times for dry heat." | 19:19 |
| Tuvix | "However, utmost care should be given to ensure the proper functioning of the N95 respirator after each decontamination using readily available qualitative fit testing tools and to ensure that treatments are carried out for sufficient time to achieve desired risk-reduction." https://doi.org/10.1101/2020.04.11.20062018 | 19:19 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A tour de force review of the T cell response to #SARSCoV2 with a focus on their role in protection from severe disease nature.com/articles/s4159…@NatImmunol pic.twitter.com/dGysZCBkI8 → https://twitter.com/EricTopol/status/1489301436760412162 | 19:22 |
| lastshell | One day when I felt bad (when I had the omicron with pain in the back) I just took sunlight | 19:47 |
| lastshell | that honestly help me | 19:47 |
| lastshell | sad they put sick people closed with no sun exposure | 19:47 |
| pwr22 | I'm ozonating two old masks I found lying around 😀 | 19:51 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Thank you @LauermanJohn for revealing the untold origin story for Pfizer's Paxlovid COVID-19 pill.The interesting part: Merck's drug boceprevir provided an essential backbone structure for Paxlovid, and boceprevir is still under [... want %more?] → https://twitter.com/michaelzlin/status/1489311054551080963 | 20:01 |
| Brainstorm | Updates for United Kingdom: +93454 cases, +321 deaths since 23 hours ago — Canada: +18499 cases, +170 deaths since 23 hours ago | 20:01 |
| de-facto | pwr22, lol you are kidding right? | 20:10 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): The article reveals many things not publicly known earlier.First, Merck had (like my own lab and others) found boceprevir to have some activity against SARSCoV2. Not too surprising, as boceprevir is a HCV protease inhibitor, and SARSCoV2 protease is [... want %more?] → https://twitter.com/michaelzlin/status/1489314545306767361 | 20:10 |
| de-facto | mask are hygiene goods, only supposed to be used one time by one consumer | 20:11 |
| de-facto | (admittedly i do reuse *my own* masks by letting them dry, but even that i am not supposed to do) | 20:12 |
| LjL | "found lying around" doesn't imply "used by others" | 20:12 |
| de-facto | depends on where that is but yeah | 20:13 |
| LjL | guess what i don't like in the replies i got here https://np.reddit.com/r/Coronavirus/comments/sj5nvb/tonga_enters_lockdown_after_first_community/hvcvc3j/ | 20:14 |
| de-facto | when i find masks lying around I take them with pointy fingers and put them into the garbage, washing my hands afterwards (in a building where other people do also wear masks) | 20:14 |
| Tuvix | /30/1 | 20:19 |
| xx | so weird that people are not used to having biohazard bags around and sending them for incineration instead of just disposing it with other trash | 20:19 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Instead Pfizer took the ball and ran with it. Paxlovid (L) copied the crucial central portion of boceprevir (R) bond by bond over 22 atoms. The ends are also altered to work better on SARSCoV2, which is also crucial. But Pfizer papers and documents [... want %more?] → https://twitter.com/michaelzlin/status/1489316863355940865 | 20:20 |
| Brainstorm | New from COVID on Twitter: Derek Lowe (@Dereklowe): For those who haven't encountered the self-styled "Queen of Canada", she's a bizarre grifter with a virulent, violent anti-vaccine message. And yes, she does claim to be in charge of the country. Which these maniacs lining up in Ottawa apparently believe? → https://twitter.com/Dereklowe/status/1489318501554786304 | 20:30 |
| LjL | oh lord here he goes again | 20:30 |
| xx | there's a queen of canada? | 20:31 |
| LjL | well, yes | 20:33 |
| LjL | but i was oh-lord'ing about Lin | 20:34 |
| xx | I'm kinda tuning out Lin. He knows his stuff but spends oh so much time on twitter... | 20:34 |
| Arsanerit | virulent anti-vaccine — no pun intended? | 20:35 |
| xx | why didn't "big pharma" buy out Lin anyway to make him shut up? | 20:36 |
| xx | almost makes me think like they have no reason to do it, because they know they are fully in the clear, but that's just a guess | 20:37 |
| LjL | well i don't think he's ever explicitly accused Pfizer of doing anything *illegal* (which would be pretty stupid to do on Twitter without an army of lawyers) | 20:38 |
| LjL | just moaning that they aren't giving credit | 20:38 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Higher antibody titres pic.twitter.com/S3alMfynVV → https://twitter.com/Marc_Veld/status/1489320128344989706 | 20:40 |
| xx | it didn't take an army of lawyers to issue fines for all sorts of previous failings of Pfizer | 20:40 |
| xx | pfizer just had enough money to pay it | 20:40 |
| xx | (this wasn't related to corona, it predates it) | 20:40 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The mystery of multiple cryptic #SARSCoV2 lineages discovered in New York City wastewaternature.com/articles/s4146…@NatureComms nytimes.com/2022/02/03/hea… @EmilyAnthes pic.twitter.com/pPO9iejXD2 → https://twitter.com/EricTopol/status/1489323310311563267 | 20:49 |
| xx | no way, they actually discovered the source | 20:50 |
| xx | oh wait, english | 20:51 |
| xx | it's mystery of 'discovered lineages' | 20:51 |
| xx | no wait, damn, it's 'discovered in new york city wastewater', not 'mystery discovered' | 20:52 |
| LjL | xx, cryptic as in people who have them don't test positive? or they simply haven't happened to sequence them in people? | 20:52 |
| xx | maybe bats live in new york sewers | 20:56 |
| Arsanerit | don't get rabies | 20:56 |
| Arsanerit | Even my corona-downplaying colleague agree that rabies is vicious | 20:57 |
| xx | I'd probably survive rabies, had the vaccine decades ago. Yeah it should be updated if one is at risk. | 20:57 |
| xx | but even then being exposed to the vaccine at any point in life does provide at least some immunity | 20:57 |
| Arsanerit | From what I understand the vaccine protection doesn't last very long, but that one can get vaccinated after infection but before symptoms start. | 20:57 |
| xx | yeah that was my case, received the vaccine and followups after being bitten | 20:58 |
| Arsanerit | And "probably survive" is not really the only criterion that's important imho. | 20:58 |
| xx | well, rabies is either you survive it, or you die | 20:58 |
| xx | and you only survive it with the vaccine | 20:58 |
| * Arsanerit prefers surviving | 20:58 | |
| * xx is undecided | 20:59 | |
| Brainstorm | New from CIDRAP: News Scan for Feb 03, 2022: Pregnancy stage and COVID severity Stroke and COVID Minnesota adds CMV screening for newborns Onion-linked Salmo probe ends → https://www.cidrap.umn.edu/news-perspective/2022/02/news-scan-feb-03-2022 | 20:59 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): As a result, the US death rate is now ~80% of its peak before vaccines and rising, whereas countries with high vaccination rates are 20-30% of their pandemic peak pic.twitter.com/YL8A1sQPyd → https://twitter.com/EricTopol/status/1489327500358393859 | 21:09 |
| xx | that nature paper is interesting read | 21:10 |
| xx | but it doesn't really provide anything actionable and is quite speculative | 21:10 |
| xx | at the very least we should start doing nose+mouth+throat+anal swabs and compare the lineages, to see if that's a possibility | 21:11 |
| xx | instead of just doing a swab from one place | 21:11 |
| LjL | don't hold your breath (except when not wearing a mask) | 21:11 |
| LjL | i feel the attempt from governments is now to downscale testing | 21:12 |
| xx | "Several species, such as cow, pig, and sheep, were identified that are not indigenous to NYC" | 21:13 |
| xx | they have cows in NYC sewers?? | 21:13 |
| xx | I know it's just funny english wording, but made me chuckle | 21:14 |
| LjL | maybe in Little India | 21:14 |
| Arsanerit | What species are indigenous to NYC? | 21:22 |
| xx | sadly humans | 21:22 |
| Arsanerit | No, they're invasive. | 21:22 |
| Arsanerit | In particular the ones that form a large majority of NYC today. | 21:23 |
| xx | yeah I guess humans are invasive species everywhere. Don't know what was on the land of NYC before humans. | 21:23 |
| xx | some big buffalo? | 21:23 |
| Arsanerit | Apparently, there are no pigs, boars, or hogs native to North America. | 21:24 |
| Arsanerit | Swine. | 21:25 |
| xx | buffalo is not closely related to any of those, thankfully. | 21:25 |
| Arsanerit | Sheep aren't native to North America either, but come from Central Asia originally. | 21:26 |
| xx | I'm in favor of rewilding North America | 21:28 |
| xx | all these invasive species just cause trouble and spread corona | 21:28 |
| Brainstorm | New from r/WorldNews: worldnews: In world first, S.Africa's Afrigen makes mRNA COVID vaccine using Moderna data → https://old.reddit.com/r/worldnews/comments/sjt0ia/in_world_first_safricas_afrigen_makes_mrna_covid/ | 21:29 |
| xx | incidentally, are there any documented deaths of animals from covid? | 21:29 |
| xx | there are documented infections, but can't find any that would have died of it | 21:29 |
| xx | following all the references on https://en.wikipedia.org/wiki/List_of_animals_that_can_get_SARS-CoV-2 | 21:30 |
| xx | not a single new species detected in 2022 so far, makes me think like they aren't doing enough testing | 21:32 |
| Arsanerit | My niece when she had covid was upset she couldn't hug her cavia / guinea pig. | 21:35 |
| xx | I wonder if the rapid tests would work on the guinea pig | 21:37 |
| xx | "Cavia porcellus, an important meat animal in South America and a common household pet outside of that continent." | 21:38 |
| xx | people seem to eat everything | 21:38 |
| xx | wonder if those creatures harbor some disease just like bats do | 21:39 |
| xx | also remind me to not take people from South America to a pet shop, they might think it's a grocery | 21:40 |
| Brainstorm | New from StatNews: Listen: Califf’s sudden jeopardy, the quest for a PCSK9 pill, & Covid vaccines for kids: Does President Biden care about the FDA? What can aerobics instructors teach us about genetics? And when can kids get Covid-19 vaccines? We cover all that and more on the… → https://www.statnews.com/2022/02/03/podcast-robert-califf-fda-pcsk9-covid-vaccine-kids/ | 21:58 |
| Brainstorm | Updates for France: +276886 cases, +264 deaths since 23 hours ago — Spain: +74368 cases, +188 deaths since 23 hours ago — United Kingdom: +92837 cases, +323 deaths since 17 hours ago — Netherlands: +82980 cases since 21 hours ago | 22:06 |
| Brainstorm | New from WebMD: Kids With COVID-Linked MIS-C Have Long-Term Symptoms: A new study finds lasting neurological complications in children following severe COVID infection. → https://www.webmd.com/lung/news/20220203/kids-with-covid-linked-mis-c-have-long-term-symptoms | 22:08 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): High vaccination level countries; vaccines work pic.twitter.com/i4iuUQRyWn → https://twitter.com/Marc_Veld/status/1489345602832015360 | 22:18 |
| Brainstorm | New from r/WorldNews: worldnews: Austria's upper house passes bill for compulsory COVID vaccine mandate → https://old.reddit.com/r/worldnews/comments/sjujub/austrias_upper_house_passes_bill_for_compulsory/ | 22:28 |
| xx | now just the president needs to sign it | 22:29 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Just out @SciImmunologyOmicron: importance of booster to restore some neutralizing antibody activity and the intact T cell (CD4+ and CD8+) response over time for 4 vaccinesscience.org/doi/10.1126/sc…@rorydevries @Corine_GvK @MarionKoopmans @bart_haagmans [... want %more?] → https://twitter.com/EricTopol/status/1489350906122432512 | 22:37 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The value of a rapid antigen test in the emergency departmentPaired testing with PCR in over 1700 people100% specificity, 100% positive predictive value, 96% negative predictive valueAllowing rapid triage of symptomatic patientspapers.ssrn.com/sol3/papers.cf… → https://twitter.com/EricTopol/status/1489354873384562689 | 22:57 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): But; "No significant differences were detected between WT- and variant-specific CD4+ or CD8+ T-cell responses, including Omicron, indicating minimal escape at the T-cell level." pic.twitter.com/dMLlsUblPC → https://twitter.com/Marc_Veld/status/1489356933719023621 | 23:06 |
| Brainstorm | Updates for Germany: +99 deaths since 22 hours ago | 23:09 |
| Brainstorm | New from CIDRAP: US COVID-19 cases continue steep decline: Stephanie Soucheray | News Reporter | CIDRAP News Feb 03, 2022 Daily cases have dropped 50% over the past 2 weeks, but deaths, known to lag cases, increased by 35%. → https://www.cidrap.umn.edu/news-perspective/2022/02/us-covid-19-cases-continue-steep-decline | 23:16 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The immune response to Covid differs in children vs adult. A new review addresses why and how that can affect clinical manifestationsnature.com/articles/s4159…@NatImmunol @BostonChildrens @PGTimmune @stjuderesearch pic.twitter.com/gKvweVulhh → https://twitter.com/EricTopol/status/1489362135767400448 | 23:26 |
| LjL | <Brainstorm> New from WebMD: Kids With COVID-Linked MIS-C Have Long-Term Symptoms: A new study finds lasting neurological complications in children following severe COVID infection. ← :( | 23:26 |
| Tuvix | Yea, I mean I don't think the disease having long-term impact is really a surprise at this point given the findings to date about interactions with organs, inflaming of other conditions (eg: the diabetes spike in youth.) Even if COVID isn't *directly* causing these things, it appears there's growing evidence it's able to make them worse regardless of the underlying science involved. | 23:32 |
| imaginary | wow that really sucks :( | 23:34 |
| Tuvix | There were some anecdotal reports of those suffering from long-COVID stating some improvement in symptoms after they got vaccinated, especially when some of them had first been able to get the vaccine with an infection prior to Sprint, 2021. | 23:35 |
| Brainstorm | New from Novavax: (news): New Zealand's Medsafe Grants Provisional Approval for Novavax' COVID-19 Vaccine → https://ir.novavax.com/2022-02-03-New-Zealands-Medsafe-Grants-Provisional-Approval-for-Novavax-COVID-19-Vaccine | 23:35 |
| Tuvix | I don't really think this should come as a shock (although more research is still needed to figure out what is going on both accute and long-term in youth especially.) For instance, if you match the death trends, they're similar wtih all the under-50 age-groups, just at different magnitudes. | 23:39 |
| Tuvix | eg: here's the (provisional) CDC data for US deaths on a log scale, through the end of 2021: https://imgur.com/pgrt7d1 | 23:40 |
| Tuvix | The under-50 group actually died in greater numbers (in each of the 4 groups presented) during Delta as compared to last Winter, while the over-50's had improved outcomes. The higher vaccination rates in the older populations likely were a major contributing factor there. | 23:41 |
| Tuvix | But, notice an important trend that is *not* any different in the under-18 age-group: they still died at about twice the level during the Delta peak as compared to winter 2020-21. | 23:42 |
| Tuvix | The peak was about 100/month (<18 years, Delta) vs. 50/month (<18 yr, Alpha.) In the 30-39 group, a similar trend: 2500/month (Delta) vs. 1100/month (Alpha), all at the peak of the waves. | 23:43 |
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