| Brainstorm | Updates for Hong Kong: +3629 cases, +20 deaths since a day ago — France: +86233 cases, +305 deaths since 22 hours ago — Italy: +53700 cases, +314 deaths since a day ago — Netherlands: +49381 cases, +16 deaths since 21 hours ago | 01:07 |
|---|---|---|
| LjL | gah how can i fail to notice that the feed bot is broken for hours | 01:47 |
| LjL | %title https://arstechnica.com/science/2022/02/omicron-subvariant-ba-2-worrying-lab-results-but-comforting-real-world-data/ | 01:47 |
| Brainstorm | LjL: From arstechnica.com: Omicron subvariant BA.2 continues global rise as experts assess mixed data | Ars Technica | 01:47 |
| oerheks | LjL, yes, a few hours without eric topol :-D | 01:51 |
| oerheks | thanks! | 01:51 |
| LjL | :P | 01:54 |
| Brainstorm | Updates for Greenland: +2 deaths since a day ago | 02:10 |
| rustynail1[m] | yet another study just came out this time from maylasia saying ivermectin does not work | 02:15 |
| qkall[m] | doesnt matter joe rogan was cured | 02:15 |
| qkall[m] | /sarcasm | 02:15 |
| rustynail1[m] | 😂 | 02:16 |
| LjL | rustynail1[m], linky? | 02:17 |
| qkall[m] | pretty sureit was top of r/science | 02:18 |
| qkall[m] | (sorry on a pinephone not easy to share atm) | 02:19 |
| rustynail1[m] | https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html | 02:27 |
| rustynail1[m] | https://www.cnn.com/2022/02/18/health/ivermectin-severe-covid-19/index.html | 02:28 |
| LjL | thanks | 02:29 |
| LjL | %title https://www.reddit.com/r/science/comments/svmsd7/ivermectin_randomized_trial_of_500_highrisk/ | 02:29 |
| Brainstorm | LjL: From www.reddit.com: Ivermectin randomized trial of 500 high-risk patients "did not reduce the risk of developing severe disease compared with standard of care alone." : science | 02:29 |
| Tuvix | Really, taking any drug with its own set of side-effects before it has a clinical grounding is a bad call, as I see it. Drugs have impacts, and understanding those and the cost/benefits afforded are crucial. | 02:30 |
| LjL | stupid Zotero spouting out random errors | 02:36 |
| rustynail1[m] | <Tuvix> "Really, taking any drug with its..." <- yeah | 02:36 |
| * Tuvix hands Brainstorm an 'lp0 on fire' error | 02:37 | |
| * Brainstorm starts to fry Tuvix with some unfeasible pelvic inflammatory disease | 02:37 | |
| rustynail1[m] | my cousin is taking it daily as a "pre exposure prophalactic" she got a doctor in florida to do it | 02:37 |
| Tuvix | Hmm, I'll stick with avocado oil for my frying, thanks :P | 02:37 |
| rustynail1[m] | she has a standing order basically now | 02:37 |
| Tuvix | Doctor-shopping to find one willing to perscribe the treatment you seek isn't exactly new. | 02:38 |
| rustynail1[m] | there are doctors in florida who are inviting anyone in the country to do telemedicine with them to get hydroxy and ivemectin | 02:38 |
| LjL | telemedicine prescriptions -.- | 02:38 |
| Tuvix | But indeed, that's probably a bad idea. There's value in getting a 2nd opinion to be sure, but it's tricky business 2nd guessing a profession most of us are less equipped than 4 years of grad school and 4+ years of medical school can offer, plus on the job practice. | 02:39 |
| rustynail1[m] | it has become a meme | 02:39 |
| Tuvix | Sure, and to the extent it's not actually illegal, it's all above-board, but it's also not how I want to get my medical treatment. | 02:39 |
| Tuvix | I'm OK doing some phone or Internet based medicine, don't get me wrong, but not to try and obtain a dubious perscription… | 02:40 |
| rustynail1[m] | yeah | 02:40 |
| rustynail1[m] | 🥺 | 02:40 |
| rustynail1[m] | i meant ivemectin and hydroxy became a meme | 02:41 |
| Brainstorm | New from ##covid-19 Zotero group: Ivermectin for the Treatment of Coronavirus Disease 2019: A Systematic Review and Meta-analysis of Randomized Controlled Trials: Type Journal Article Author Yuani M Roman Author Paula Alejandra Burela Author Vinay Pasupuleti Author Alejandro Piscoya Author Jose E Vidal Author Adrian [... want %more?] → https://www.zotero.org/groups/covid_links/items/F3MV9ENG | 02:45 |
| Alex1138[m] | the cure for covid is obviously to put 0.00000000000000000001 micrograms of covid in a glass of water and drink it | 02:52 |
| LjL | Alex1138[m], uh, how is that going to work without enough succussion to increase the potency? | 02:53 |
| Alex1138[m] | i haven't heard of it happening yet but i would be surprised if the homeopathy industry hasn't already marketed a covid cure | 02:54 |
| LjL | Alex1138[m], https://www.youtube.com/watch?v=WHC1bY_qdQ0&t=72s (just this segment, ignore the actual topic, well unless you're interested) | 02:59 |
| LjL | hmm to be fair though, the Malaysian study doesn't seeeeem exceptionally strong in disproving ivermectin, https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2789362 i only just read the abstract, but for every outcome, fewer patients on ivermectin than patients on nothing had that outcome. in NO case it was p<0.05, but i'm preeeeetty sure someone really convinced ivermectin IS useful would want a larger study, or a study of the same size that | 03:07 |
| LjL | happens to actually end up with more bad outcomes in people on nothing that people on ivermectin (and i say "nothing", not placebo, because it was open-label) | 03:07 |
| qkall[m] | I've said it before... LjL bless you and your efforts | 03:28 |
| LjL | :) | 03:34 |
| LjL | it was "more fun" back when i was translating and transcribing fancy press conferences... and... we still naively thought this would "end" ;( | 03:35 |
| Brainstorm | Updates for Brunei: +2988 cases, +10 deaths since a day ago — New Zealand: +1816 cases, +30643 tests (5.9% positive) since 23 hours ago — Tonga: +24 cases since 21 hours ago | 04:02 |
| Brainstorm | New from ##covid-19 Zotero group: Rapid Deployment Vaccine Collaborative: Type Encyclopedia Article URL https://en.wikipedia.org/w/index.php?title=Rapid_Deployment_Vaccine_Collaborative&oldid=1066152030 Rights Creative Commons Attribution-ShareAlike License Date 2022-01-17T02:01:05Z Extra Page Version ID: 1066152030 [... want %more?] → https://www.zotero.org/groups/covid_links/items/64X3XMQ9 | 04:25 |
| Brainstorm | Updates for Germany: +52122 cases since 22 hours ago | 05:05 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Re-reading James Rini's underrated paper on CoV-229E RBD: elifesciences.org/articles/51230 Astonishing 25 of 31 (81%) of residues in 229E RBD that contact receptor varied during virus's evolution in humans over last ~50 yrs. #SARSCoV2 RBD is *not* going to run out [... want %more?] → https://twitter.com/jbloom_lab/status/1494886577159356418 | 05:13 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Sorry, did not mean this to be depressing Tweet. Vaccines & immunity can (and are) doing a lot to blunt infections & disease severity. But virus will evolve & vaccine strategies need to keep that in mind (as everyone now knows). Papers like help provide long view [... want %more?] → https://twitter.com/jbloom_lab/status/1494890028366917637 | 05:32 |
| Brainstorm | Updates for Cook Is.: +3 cases, +863 tests (0.3% positive) since a month ago | 06:07 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): WHO announces first technology recipients of mRNA vaccine hub with strong support from African and European partners who.int/news/item/18-0… → https://twitter.com/Tuliodna/status/1494902160148074499 | 06:20 |
| Brainstorm | Updates for Krasnoyarsk, Russia: +7823 cases, +28 deaths since a day ago — Sabah, Malaysia: +5565 cases, +6 deaths since a day ago — Novosibirsk, Russia: +5319 cases, +15 deaths since a day ago — Bashkortostan, Russia: +4504 cases, +18 deaths since a day ago | 07:10 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Arkansas' daily covid death toll hits new 1-year high → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/sw3jnk/arkansas_daily_covid_death_toll_hits_new_1year/ | 07:55 |
| Brainstorm | Updates for Cambodia: +552 cases since 13 hours ago — Vanuatu: +4 cases since a month ago | 08:00 |
| Brainstorm | New from Science-Based Medicine: That latest article on the post vaccine myocarditis autopsy analysis: The autopsy report for two teens who allegedly died of vaccine myocarditis was released this week. What are the implications for vaccinating children and adolescents? [... want %more?] → https://sciencebasedmedicine.org/that-latest-article-on-the-post-vaccine-myocarditis-autopsy-analysis/ | 09:02 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Gut health compromised in severe COVID-19: New research of samples of intestine from people who have died of COVID-19 has shown the impact of the virus on the gut immune system. → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/sw55tk/gut_health_compromised_in_severe_covid19_new/ | 10:28 |
| Brainstorm | New from COVID on Twitter: Florian Krammer (@florian_krammer): Very close relatives of SARS-CoV-2 found.....in bats in Laos. Great paper. nature.com/articles/s4158… → https://twitter.com/florian_krammer/status/1494992437944668163 | 12:11 |
| Brainstorm | New from Reddit (test): Possible scam going around?: submitted by /u/Open_Standard_655 to r/CoronavirusUK → https://old.reddit.com/r/CoronavirusUK/comments/sw8azx/possible_scam_going_around/ | 13:09 |
| Brainstorm | Updates for Indonesia: +59384 cases, +158 deaths, +489780 tests (12.1% positive) since 19 hours ago | 14:02 |
| Brainstorm | New from Reddit (test): Covid2019: Which Way Will the Pandemic Swing? UK Body Offers Four Scenarios → https://old.reddit.com/r/Covid2019/comments/swa0cf/which_way_will_the_pandemic_swing_uk_body_offers/ | 14:45 |
| Brainstorm | New from Contagion Live: Booster Efficacy Wanes After 4 Months, Still Protects Against Severe COVID-19: COVID-19 mRNA vaccine effectiveness wanes even faster during Omicron than during Delta variant predominance, but a booster dose still provides lasting defense [... want %more?] → https://www.contagionlive.com/view/booster-efficacy-wanes-after-4-months-still-protects-against-severe-covid-19 | 15:04 |
| Brainstorm | Updates for Germany: +159268 cases since 21 hours ago | 15:04 |
| Brainstorm | New from COVID on Twitter: Amy (@skepticalzebra): @apsmunro Covid twitter only permits jokes comparing covid to meteorological phenomena Alasdair. Thems the rules. → https://twitter.com/skepticalzebra/status/1495039578721427464 | 15:32 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): @LongDesertTrain @ProfessorRees CoV-229E mild as long as we've known about it. Was isolated in 1966 & next year they infected 26 volunteers: half developed colds ncbi.nlm.nih.gov/labs/pmc/artic… Of course 229E probably jumped to humans way before 1966. [... want %more?] → https://twitter.com/jbloom_lab/status/1495045679151935495 | 15:52 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): If you’re free at 5 pm EST (11 pm CET) on Tuesday and want to understand more about Covid and effects on the brain, I recommend this talk by @AndrewEwing11, who’s been following the topic closely over time. @TheWHN twitter.com/thewhn/status/… → https://twitter.com/GANyborg/status/1495059596918022145 | 16:40 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Also a reduced hospitalization rate observed in babies born to vaccinated mothers, reported here from CDC. twitter.com/MichiWagner4/s… → https://twitter.com/GANyborg/status/1495063192971751427 | 17:00 |
| Brainstorm | Updates for Germany: +164941 cases, +165 deaths since 23 hours ago | 17:09 |
| Brainstorm | New from COVID on Twitter: Prof. Akiko Iwasaki (@VirusesImmunity): The latest summary of “How Long Covid Exhausts the Body” by @joshkellerjosh. Visual journalism at its best Happy to contribute insights with @nathavindra. Ft. @PutrinoLab @michelle_monje @microbeminded2 @Survivor_Corps @itsbodypolitic & [... want %more?] → https://twitter.com/VirusesImmunity/status/1495072211799101440 | 17:28 |
| Brainstorm | Updates for Myanmar: +3050 cases, +5 deaths since 23 hours ago | 17:59 |
| Brainstorm | New from LitCovid: (news): Does SARS-CoV-2 really affect the prostate? Pathological and molecular analysis from a COVID-19 recovered patient treated with holmium laser enucleation of the prostate. → https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/35176930 | 18:16 |
| lastshell | maybe off-topic but russina ukraine things are not looking good | 18:42 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): There is so many misinterpretations of deaths with omicron, specially BA.2, which currently dominates in SA. Please note that most of our daily deaths reported are old ones due to data consolidation, see below: 319 deaths OF WHiCH 9 occurred in the last 24-48h! [... want %more?] → https://twitter.com/Tuliodna/status/1495089481984233476 | 18:45 |
| Brainstorm | Updates for Malaysia: +28825 cases, +34 deaths since 18 hours ago — Italy: +50675 cases, +252 deaths, +1002328 tests (5.1% positive) since 18 hours ago | 19:08 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): I have seen absolute nonsense analysis of recent death of omicron BA.2 in South Africa around the world. Please @rid1tweets @Rajeev_The_King , can you show us the number of deaths per 100,000 people I. SA in the last few weeks, since BA.2 is at high prevalent? → https://twitter.com/Tuliodna/status/1495098298063101954 | 19:14 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Please note that South Africa has a very high population immunity, good vaccination in people >40 and had a very severe Beta, Delta and Omicron wave so much of the low hospitalization and deaths of BA.2 is confounded by those facts. → https://twitter.com/Tuliodna/status/1495098299954741255 | 19:24 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Among countries in the world, the United States currently ranks #67 for "fully vaccinated" and #54 for boostersig.ft.com/coronavirus-va… pic.twitter.com/QU1aSNbKEa → https://twitter.com/EricTopol/status/1495105097549824002 | 19:43 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Pfizer's selection of the nitrile reactive group (warhead) was important because it improved cell permeability and oral bioavailability. Thus nirmatrelvir can reach very high levels in the blood after oral ingestion. Another company, Pardes, also use [... want %more?] → https://twitter.com/michaelzlin/status/1495108402313240576 | 19:53 |
| oerheks | https://www.brusselstimes.com/206697/eu-to-throw-away-55-million-covid-vaccines-by-end-of-month | 19:58 |
| oerheks | https://www.reuters.com/business/healthcare-pharmaceuticals/eu-africa-aim-resolve-vaccine-patent-dispute-by-spring-eu-chief-2022-02-18/ | 19:58 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): One worry is that the SARSCoV2 pool may contain mutants that resist Pfizer of Pardes protease inhibitors and that may get selected after these inhibitors become widely used. This has gotten some attention recently. pic.twitter.com/cJvf2bFrGu → https://twitter.com/michaelzlin/status/1495110495958753283 | 20:02 |
| Brainstorm | Updates for United Kingdom: +34055 cases, +128 deaths since 19 hours ago | 20:10 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): As Pfizer and Pardes (which raised $200M) are covering nitrile-based SARSCoV2 inhibitors, we continue to work on non-nitrile inhibitors. We recently expanded ML1000 to make a series of orally bioavailable drugs (thx to @Stanford_ChEMH, Coulter [... want %more?] → https://twitter.com/michaelzlin/status/1495111235360067584 | 20:12 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): It remains to be seen if this will hold true for all nitrile compounds and all ketoamide compounds, but these results indicate it's crucial to not rely on one type of reactive group such as the nitrile. Rather, diversification of SARSCoV2 requires us [... want %more?] → https://twitter.com/michaelzlin/status/1495115681548804098 | 20:21 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): And while a nitrile warhead is one way to enhance oral delivery, it's not the only way. We've recently achieved oral bioavailability without nitriles via some imaginative chemistry (patented, sorry Pfizer). This may be a route to drugs better than [... want %more?] → https://twitter.com/michaelzlin/status/1495125057781190658 | 21:00 |
| Brainstorm | Updates for Canada: +5322 cases, +34 deaths since 19 hours ago | 21:07 |
| LjL | new meta-analysis about vitamin D, this one finds a significant reduction in mortality https://academic.oup.com/qjmed/advance-article-abstract/doi/10.1093/qjmed/hcac040/6528876?login=false | 21:09 |
| LjL | i haven't read it, i don't know if it's bollocks, i feel that reviews, sure, they are in theory "more meaningful" than individual studies, but in practice cherrypicking studies in various ways can be a big problem with them | 21:09 |
| LjL | i mean this is a meta-review so a review of reviews which like, good luck | 21:10 |
| LjL | i don't know how they can find this finding given most of the reviews i eyed before were like "nope, D doesn't help" | 21:11 |
| LjL | but then individual studies always showed a fair amount of correlation | 21:11 |
| Arsanerit | la metá | 21:11 |
| LjL | "but it doesn't have to be causation", okay, but it also can be | 21:11 |
| LjL | Arsanerit, ´ makes a difference :P | 21:11 |
| LjL | (also it's `) | 21:11 |
| Arsanerit | a review of a review of review of review? Recursion, see recursion. | 21:11 |
| Arsanerit | A review of all papers not reviewing themselves. | 21:12 |
| LjL | also why is this article classified as "Corrected proof"? (above the title in small caps) | 21:13 |
| LjL | also this article is not actually free access :( | 21:13 |
| LjL | unlike... almost every COVID article around? | 21:13 |
| LjL | i was thinking the other day, by the way: do you think the day WHO declares the end of the pandemic, all the COVID articles will retroactively stop being open access? | 21:14 |
| Arsanerit | that would be a major effort | 21:17 |
| LjL | and, what about *new* articles about COVID coming after that? | 21:18 |
| Tuvix | Items like medical preprints are typically given a right to be displayed on their relative preprint sites/servers forever, but that won't address sites like NYT and many others that don't put much/most/all (varies by agency) of their articles behind paywalls, only nag-boxes to ask you to subscribe. | 21:42 |
| Tuvix | Medical information being open is good both for researchers and the general public, but sadly the general public doesn't often have the patience or basic training in critical thinking to even begin to evaulate a 10-to-50 page preprint.= | 21:43 |
| Tuvix | That's where good articles really can matter, especially if they go out of their way to rely on good information and link sources. | 21:43 |
| LjL | Tuvix, well this is a preprint according to the person who answered my question ( https://www.reddit.com/r/China_Flu/comments/swi6rt/does_vitamin_d_supplementation_reduce_covid19/hxmb1bg/?context=3 ) but it's not open access... | 21:44 |
| Tuvix | According to the NIH entry† it is " | 21:46 |
| Tuvix | QJM | 21:46 |
| Tuvix | . 2022 Feb 15;hcac040. | 21:46 |
| Tuvix | doi: 10.1093/qjmed/hcac040. Online ahead of print. " | 21:46 |
| Tuvix | Oof, hidden newlines :\ | 21:46 |
| Tuvix | † https://pubmed.ncbi.nlm.nih.gov/35166850/ | 21:46 |
| Tuvix | Anyway, "online ahead of print" doesn't necessarily mean open-access :\ | 21:47 |
| LjL | yeah that has a link that goes " Full Text Sources Silverchair Information Systems " and if i click that it goes back to oup where it says "You do not currently have access to this article" ;( | 21:48 |
| Tuvix | Right, and the "Sign in" page description informs me that, if I create an account, I could "Save searches" and "Purchase content" | 21:48 |
| Tuvix | ie: paywall | 21:48 |
| LjL | having just the abstract of something like this really doesn't tell us anything | 21:48 |
| LjL | "the two of us looked at 10 reviews on vit D and we review in turn that it is useful" | 21:49 |
| LjL | why thank you | 21:49 |
| Tuvix | Right, and while normal supplement levels of various vitamins probably won't hurt most people, the causality is harder to review correctly. | 21:49 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): Good thread on BA.2, new Omicron variant: observational data in patients doesn’t, for now, support conclusion that BA.2 is more virulent, or causes widespread reinfections in those recovered from Omicron. This real world experience should be [... want %more?] → https://twitter.com/ScottGottliebMD/status/1495136668403310592 | 21:50 |
| LjL | well, someone on r/COVID19 posted the full text | 21:50 |
| LjL | i wouldn't willingly give the link to that as of course https://pdfhost.io/v/yBsTSEkKU_OPQJMD220040_18 | 21:50 |
| LjL | whoops i pressed ctrl+v by mistake | 21:50 |
| LjL | sorry | 21:50 |
| LjL | they looked at 10221 articles and eventually excluded 10178 (before excluding more...) | 21:51 |
| Tuvix | Hey, if I can fumble my paste above, so can you ;) | 21:51 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): Other studies show in those who were vaccinated and subsequently infected with BA.1 Omicron, there was little difference in the ability of antibodies patients developed to neutralize the virus when comparing their antibody activity against BA.1 [... want %more?] → https://twitter.com/ScottGottliebMD/status/1495138599750283274 | 21:59 |
| Tuvix | I'm not sure this is a very useful comparison given the impact of the varients and social behaviors in the US in particular, but I split the pandemic into two parts, pre-vaccine and post-vaccine, selecting Jun-01 '21 as the cutoff where we had ample supply but the demand is was drove down vaccinations by that point. | 22:08 |
| Brainstorm | Updates for Germany: +102 deaths since 21 hours ago | 22:09 |
| Tuvix | US pandemic-total fatality rate has been 2.73 (per 7-day per 100k pop.) The early-pandemic, April 2020 - May 2021 was 2.93, and post-vaccines (June 2021 - Feb 18 2022) is 2.70 | 22:09 |
| Tuvix | That's not much of a change between them, all things considered, but here again, each varient has shown to have some degree of immune-escape and we have quite an ample supply of unvaccinated still. | 22:10 |
| Brainstorm | Updates for France: +76552 cases, +147 deaths since 21 hours ago | 22:59 |
| oerheks | In NL, numbers drop .. due to a storm, that is... https://www.worldometers.info/coronavirus/ | 23:01 |
| Tuvix | Quite a spike in cases, yes, although now the question is what impact on the severe outcomes such as ICU and death result. | 23:08 |
| Tuvix | Back with the Delta surge in NL using OWID, it looks like the ICU pace didn't tick up until about 15 days after the surge in cases. With Omicron, NL seems to have reached the point of sharply rising cases around Jan-06 or so, and you'd have expected any corresponding rise in ICU by late-Jan into early-Feb. There was a small uptick first week of Feb, but a very minor one. | 23:09 |
| Tuvix | Deaths in NL are up a bit, but we'll have to wait another couple weeks to see what the resulting impact is. It could well end up far less of an impact on lives lost than Delta, but that depends on outcomes really. | 23:11 |
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