| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Unfortunately it looks like both issues are going to be with us for a while, so I'll have to continue tweeting about COVID19. It means no disrespect to Ukraine even though Ukraine is the more immediate and tragic issue. → https://twitter.com/michaelzlin/status/1499156808568504320 | 00:01 |
|---|---|---|
| LjL | we have to apologize for talking about COVID now? | 00:03 |
| oerheks | Are you trying to change the climate, LjL ? | 00:06 |
| LjL | oerheks, hmm? | 00:07 |
| oerheks | oh, it was a joke | 00:08 |
| Brainstorm | Updates for Malaysia: +27500 cases, +115 deaths, +230117 tests (12.0% positive) since a day ago | 00:10 |
| Brainstorm | New from COVID on Twitter: Chemjobber (@Chemjobber): 500,000 courses X 3 grams/course = 1500 KG API, which I bet is the majority of Pfizer inventory on 12/31/21 twitter.com/EricTopol/stat… → https://twitter.com/Chemjobber/status/1499159107286171651 | 00:20 |
| Brainstorm | New from The Lancet (Online): [Correspondence] Vaccine approval before phase 3 trial results: a consequence of vaccine access inequity: The final phase 3 clinical data for CanSino Biologics' adenovirus type 5 vector vaccine show that Ad5-nCoV is efficacious.1 However, emergency approval was [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00164-7/fulltext | 00:39 |
| Brainstorm | Updates for Hong Kong: +55353 cases, +178 deaths since 23 hours ago | 01:00 |
| LjL | %more | 01:08 |
| Brainstorm | LjL, [...] granted in ten countries before data on its efficacy were available, even though other vaccines were already approved.1 If the results of the trial had been unfavourable, millions of people would have been vaccinated and granted a false sense of protection. If this scenario had happened, the decision to approve the vaccine for emergency use would have [...] → https://paste.ee/p/gfAjy | 01:08 |
| LjL | whatever they've used in HK doesn't seem to be exceptionally efficacious | 01:08 |
| Brainstorm | Updates for Slovakia: +15871 cases since 23 hours ago — Cook Is.: +18 cases, +174 tests (10.3% positive) since a day ago — Canada: +6794 cases, +81 deaths, +37824 tests (2.2% positive) since 23 hours ago — United Kingdom: +45303 cases since 21 hours ago | 02:02 |
| Brainstorm | New from r/Science: science: Covid has intensified gender inequalities, global study finds → https://old.reddit.com/r/science/comments/t5eb5u/covid_has_intensified_gender_inequalities_global/ | 02:24 |
| Brainstorm | Updates for Germany: +77571 cases since 15 hours ago | 03:05 |
| Brainstorm | Updates for Vietnam: +151852 cases, +201554 tests (75.3% positive) since 23 hours ago — New Zealand: +23178 cases, +40430 tests (57.3% positive) since 23 hours ago | 04:02 |
| sueno | actually i stopped reading topol and lin because they started with that topic , and it's exhausting | 04:52 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): @nytimes Per French study, J&J protection from hospitalization 1-3mo postvax is only 59%, 5x worse than Pfizer-BioNTech. This adds to the VA study.The original Ph3 trial found 0 of 16 hospitalizations were in vaxxed group after 1mo; this now seems [... want %more?] → https://twitter.com/michaelzlin/status/1499231535668416516 | 04:57 |
| LjL | sueno, what topic? | 05:08 |
| LjL | the war? | 05:08 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Since certain internet trolls like to ask me about COIs when I talk about pills, I'm developing protease inhibitors that function similarly to Paxlovid, the drug Biden mentioned (and we had ours first, so we're not copying Pfizer). But I tend to call [... want %more?] → https://twitter.com/michaelzlin/status/1499236220202733571 | 05:17 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Vaccination prevents hospitalizations by ~90%, the same as Paxlovid, and you can carry that benefit with you 24/7; you don't need to run to get tested with every sniffle. → https://twitter.com/michaelzlin/status/1499237300961640455 | 05:26 |
| Brainstorm | New from r/Science: science: People with weakened immune systems established to respond poorer to covid-19 vaccines, but a third dose of a covid-19 mRNA vaccine is associated with seroconversion among vaccine non-responders with solid cancers, blood cancers, and immune [... want %more?] → https://old.reddit.com/r/science/comments/t5iyiv/people_with_weakened_immune_systems_established/ | 06:22 |
| Brainstorm | Updates for Saxony, Germany: +14608 cases, +17 deaths since a day ago — Selangor, Malaysia: +6494 cases, +18 deaths since a day ago — Biobio, Chile: +5299 cases since a day ago — Maule, Chile: +4451 cases since a day ago | 07:08 |
| Brainstorm | New from MedicineNet: (news): Variants of COVID Virus May 'Hide Out' in Body: Study → http://www.medicinenet.com/script/main/art.asp | 07:37 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 03, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/t5mjh8/daily_discussion_thread_march_03_2022/ | 09:03 |
| Brainstorm | New from BMJ: Covid-19: Public vaccine funding needs “strings attached” for equitable access, say campaigners: Public funding given to companies for future vaccine development should have global access requirements built into agreements to avoid the inequity seen during the covid-19 pandemic, campaigners have... → http://www.bmj.com/content/376/bmj.o565.short | 09:32 |
| Brainstorm | Updates for France: +686 cases since 12 hours ago | 10:26 |
| Brainstorm | New from BBC Health: Covid: How could the pandemic have affected your brain?: Scientists say uncertainty and disruption have affected people even if they haven't had Covid. → https://www.bbc.co.uk/news/uk-wales-60558431 | 10:39 |
| Brainstorm | Updates for Brunei: +4885 cases, +6 deaths since 23 hours ago — United Kingdom: +1551 cases since 15 hours ago | 11:10 |
| zutt | %cases finland | 11:15 |
| * zutt pokes Brainstorm | 11:19 | |
| * Brainstorm starts to chew up zutt with some immobile stomach flu | 11:19 | |
| zutt | ;O | 11:19 |
| Brainstorm | New from BMJ: Pandemic has accelerated demand for private healthcare, report finds: More UK adults are seeking private healthcare as poor access to care exacerbated by the pandemic threatens to create a two tier system, a report has warned.1Research by the Institute for Public... → http://www.bmj.com/content/376/bmj.o566.short | 11:45 |
| Brainstorm | New from ECDC: Data on country response measures to COVID-19: This downloadable data file contains information on non-pharmaceutical interventions (or response measures) that countries in the EU/EEA have reported to date. → https://www.ecdc.europa.eu/en/publications-data/download-data-response-measures-covid-19 | 12:05 |
| Brainstorm | New from COVID on Twitter: Sam Wilkinson (@BioWilko): Our pre-print into recurrent sars-cov-2 mutations in immunodeficient patients is out on medrxiv, please give it a read!@pathogenomenick @PeacockFlu @myxosparkus @AlexRichter3 @Scalene @NicolaCumley @samstudio8 twitter.com/medrxivpreprin… → https://twitter.com/BioWilko/status/1499359600113553410 | 13:30 |
| Brainstorm | Updates for Germany: +213125 cases since 22 hours ago | 13:33 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): UKHSA, which reports weekly, data now in NEJMCovid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant: C19 vaccines are 3 doses. Protection against infection will, of course, wane. nejm.org/doi/full/10.10… → https://twitter.com/Marc_Veld/status/1499367088418398208 | 14:00 |
| Brainstorm | Updates for France: +521169 cases, +1975 deaths since 15 hours ago | 14:04 |
| Brainstorm | New from Virology.ws: An Intranasal SARS-CoV-2 Vaccine Candidate: Intranasal administration with a single dose of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine induces potent immune responses. → https://www.virology.ws/2022/03/03/an-intranasal-sars-cov-2-vaccine-candidate/ | 14:19 |
| Brainstorm | New from r/COVID19: COVID19: Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation → https://old.reddit.com/r/COVID19/comments/t5s3qi/understanding_the_effects_of_age_and_tcell/ | 15:08 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: U.S. will share some coronavirus technologies with WHO; Civica Rx tries unconventional bid to make cheap insulin → https://www.statnews.com/pharmalot/2022/03/03/covid19-biden-who-insulin-opioids-purdue-alzheimers/ | 15:37 |
| Brainstorm | New from BBC Health: Another life-saving Covid drug identified: An anti-inflammatory for rheumatoid arthritis can cut Covid death risk by about a fifth. → https://www.bbc.co.uk/news/health-60601750 | 16:06 |
| Brainstorm | Updates for Germany: +213053 cases since 23 hours ago — Canada: +64 deaths since 23 hours ago | 16:14 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): New Zealand's Omicron wave in the news for cases skyrocketing nytimes.com/2022/03/03/wor…But it should be for recognizing it as a model country for managing the pandemic, high vaccination, booster rate, 56 deaths total over 2 years among 4.9 million people [... want %more?] → https://twitter.com/EricTopol/status/1499402359511740422 | 16:16 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The #SARSCoV2 mutations that evolve within immunocompromised people with chronic infection, a potential source of new variants, are recurrent and different from those that promote transmission medrxiv.org/content/10.110… @pathogenomenick @PeacockFlu @BioWilko [... want %more?] → https://twitter.com/EricTopol/status/1499406735211053057 | 16:35 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): 2 places with severe Omicron outbreaks that started the same time. The difference in fatalities pic.twitter.com/qezVyxmsCF → https://twitter.com/EricTopol/status/1499407696075767809 | 16:45 |
| Brainstorm | New from ClinicalTrials.gov: (news): Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy Participants → https://clinicaltrials.gov/ct2/show/NCT05263921 | 17:04 |
| Brainstorm | New from ClinicalTrials.gov: (news): Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet Formulation → https://clinicaltrials.gov/ct2/show/NCT05263895 | 17:14 |
| Brainstorm | New from ClinicalTrials.gov: (news): The Effect of Video Information on Anxiety in Adolescents Having rRT-PCR Test During Corona Virus Pandemic → https://clinicaltrials.gov/ct2/show/NCT05265390 | 17:43 |
| oerheks | easing restrictions, a week later; whole village positive ( due to karnaval) https://www.telegraaf.nl/video/1235341805/drukte-bij-teststraat-door-carnaval-heel-stratum-is-positief | 17:49 |
| Brainstorm | New from ClinicalTrials.gov: (news): General Investigation for PAXLOVID PACK → https://clinicaltrials.gov/ct2/show/NCT05263908 | 17:53 |
| Brainstorm | New from ClinicalTrials.gov: (news): Outcomes of Obstetric Patients With COVID-19 Disease in the ICU → https://clinicaltrials.gov/ct2/show/NCT05264987 | 18:03 |
| Brainstorm | New from ClinicalTrials.gov: (news): Evaluation of Full Versus Fractional Dose of COVID-19 Vaccine Given as a Booster for the Prevention of COVID 19 in Adults in Mongolia- Mongolia, Indonesia, Australia Coronavirus (MIACoV). → https://clinicaltrials.gov/ct2/show/NCT05265065 | 18:12 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A rare (<2%) genome variant that downregulates ACE2 expression reduces the risk of severe Covid by 40%nature.com/articles/s4158…@NatureGenet → https://twitter.com/EricTopol/status/1499435781550927875 | 18:32 |
| Brainstorm | Updates for Malaysia: +32332 cases, +83 deaths since 18 hours ago | 19:02 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The current booster vaccine rate in the UK for age 65+assets.publishing.service.gov.uk/government/upl…The US rate for age 65+ is 66% pic.twitter.com/boBeMnu05g → https://twitter.com/EricTopol/status/1499445083979993101 | 19:10 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Will the next variant look like Omicron? "Due to its asymptomatic spread, SARS-CoV-2 is not under pressure to evolve toward becoming less virulent. However, this also does not mean that it will become more virulent" → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/t5y5xu/will_the_next_variant_look_like_omicron_due_to/ | 19:30 |
| Brainstorm | New from Reddit (test): Covid2019: Living in a COVID-19 Pandemic While Immunocompromised → https://old.reddit.com/r/Covid2019/comments/t5ymg2/living_in_a_covid19_pandemic_while/ | 19:49 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A new randomized trial of baricitinib, a repurposed rheumatoid arthritis drug, in over 8,000 patients with severe Covid, reduces mortality science.org/content/articl… by @kakape #RECOVERYExplainer twitter.com/kakape/status/… pic.twitter.com/QJ6FyI2DDe → https://twitter.com/EricTopol/status/1499459173481795601 | 20:09 |
| Brainstorm | New from CIDRAP: Third vaccine dose boosts Omicron protection, with some waning: Mary Van Beusekom | News Writer | CIDRAP News Mar 03, 2022 A third dose with any of 3 COVID-19 vaccines boosted effectiveness substantially. → https://www.cidrap.umn.edu/news-perspective/2022/03/third-vaccine-dose-boosts-omicron-protection-some-waning | 20:57 |
| Brainstorm | Updates for United Kingdom: +46894 cases, +195 deaths since 23 hours ago — Italy: +42588 cases, +185 deaths, +431312 tests (9.9% positive) since a day ago | 21:00 |
| Brainstorm | New from Contagion Live: us: Patients Hospitalized for COVID-19 Rarely Required Antibiotics → https://www.contagionlive.com/view/patients-hospitalized-for-covid-19-rarely-required-antibiotics | 21:17 |
| LjL | %print https://twitter.com/cochranecollab/status/1458439812357185536 | 21:28 |
| Brainstorm | LjL, It says: Cochrane (@cochranecollab): "🤔 Um, @instagram you got this one wrong! @cochranecollab and @CochraneLibrary continue to be there for those looking to use high-quality information to make #health decisions. Learn more: https://buff.ly/2R3c82O And search our evidence: https://buff.ly/2vbkhIJ #infodemic" | 42l - nitter | 21:29 |
| LjL | Cochrane shadowbanned from Instagram for COVID misinformation, gold | 21:29 |
| Brainstorm | New from r/COVID19: COVID19: Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models → https://old.reddit.com/r/COVID19/comments/t60lfj/vaccination_with_sarscov2_spike_protein_lacking/ | 21:46 |
| LjL | de-facto, some kind of model here https://twitter.com/CT_Bergstrom/status/1499497664777318425 | 22:33 |
| Brainstorm | New from NPR Science: Striking new evidence points to seafood market in Wuhan as pandemic origin point: Two studies point to a link between the animals at the seafood market and the spread of SARS-CoV-2 — foreshadowed by photos [... want %more?] → https://www.npr.org/sections/goatsandsoda/2022/03/03/1083751272/striking-new-evidence-points-to-seafood-market-in-wuhan-as-pandemic-origin-point | 22:40 |
| Brainstorm | New from CIDRAP: Third vaccine dose boosts Omicron protection, with some waning: Mary Van Beusekom | News Writer | CIDRAP News Mar 03, 2022 A third dose with any of 3 COVID-19 vaccines boosted effectiveness substantially. → https://www.cidrap.umn.edu/news-perspective/2022/03/third-vaccine-dose-boosts-omicron-protection-some-waning | 22:50 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): A larger study; vaccines work well in children:Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 Years Hospitalized with COVID-19cdc.gov/mmwr/volumes/7… → https://twitter.com/Marc_Veld/status/1499506418298273794 | 23:09 |
| Brainstorm | Updates for Ivory Coast: +4000 cases since 22 hours ago — Spain: +23140 cases, +202 deaths since a day ago — France: +522821 cases, +1977 deaths since 12 hours ago — Germany: +201833 cases since 22 hours ago | 23:09 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): This is unexpected; there are no known ACE2 mutations that would reduce risk of SARS-CoV-2 infection; but there is a SNP, rs190509934, that downregulates expression. Only 0.2-2% of people have it; but 40% protection against infection.nature.com/articles/s4158… → https://twitter.com/Marc_Veld/status/1499508495225401345 | 23:18 |
| LjL | Tuvix: https://mobile.twitter.com/Liveuamap/status/1499305199462236161 | 23:30 |
| LjL | Err | 23:30 |
| LjL | No | 23:30 |
| LjL | Tuvix: https://mobile.twitter.com/clg6000/status/1499503071256354817 | 23:31 |
| Tuvix | LjL: Yea, that's basically the message now; especially concerning is on one hand saying that masks aren't needed for most of the US or most situations, but at the same time citing masks as tools to help keep spread down and protect those who need it. | 23:47 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): For those needing the extra help of monoclonal antibody therapy after SARS-CoV-2 infection. Some are no longer binding to Omicron; but others do very well against all sublineages.nature.com/articles/s4158… → https://twitter.com/Marc_Veld/status/1499514278981820417 | 23:47 |
| Tuvix | So, which *is* it? Are masks tools we should be promoting, or no longer necessary? They can't be both, and the distinction of when they're to be used is utterly lacking at the political messaging, and largely even the health messaging, especially at the higher levels. | 23:47 |
| LjL | Tuvix, but also i got that from a tweet that implied there would no longer be free testing, so we'll basically lose the data | 23:48 |
| Tuvix | From that 2-page tweet image you linked, calling it like the flu based on deaths clearly shows the author of that document has zero clue what they're talking about. | 23:49 |
| Tuvix | Yesterday's 7-day daily average of deaths was 1674. An annual-averaging of the flu would be 98 | 23:50 |
| bin | > They can't be both | 23:51 |
| bin | why not? | 23:51 |
| Tuvix | We're off by well over an order of magnitude on fatalities alone, nevermind the other side-effects which are shown to last for months sometimes. | 23:51 |
| bin | They're tools that we should be promoting, but they're not necessary for everyone anymore. | 23:51 |
| Tuvix | bin: Because we know the dangers of continuing to spread this disease is, at present, 17 times the rate of death. | 23:51 |
| bin | Ultimately pragmatism is key here | 23:51 |
| Tuvix | The problem is that it's NOT targeted to metrics states and cities can apply usefully, and most places gave up months ago. | 23:51 |
| Tuvix | Around here I could test positive today, and be under no requirement to avoid things like spending hours indoors, dining, at bars, social gatherings, and so on. | 23:52 |
| Tuvix | It's against national (and state) guidance, but how is that good for society? | 23:52 |
| LjL | here you're talking about 17x the death rate of the flu as being a lot | 23:53 |
| Tuvix | Getting "back to normal" is an excuse to green-light these kinds of behaviors that were already bad, but what we're doing is normalizing a rate of death that's more than a year's worth of influenza death occurring each *month* with COVID, and effectively giving up on any meaningful mitigation. | 23:53 |
| LjL | but let me borrow this from ##coronavirus | 23:53 |
| LjL | <xMopx> has this made the rounds yet? https://www.bloomberg.com/news/articles/2022-03-03/omicron-is-40-deadlier-than-seasonal-flu-japanese-study-finds | 23:53 |
| LjL | <xMopx> sounds like incredible news, quite a step down from the 100x deadlier figure in the past | 23:53 |
| LjL | xMopx apparently thinks that 40x the flu is not much, because they expected 100x | 23:53 |
| LjL | it feels surreal to me | 23:54 |
| ecks | 40x??? | 23:54 |
| ecks | 40% is not 40x | 23:54 |
| LjL | ecks, indeed. but they thought it was 40x and they previously had a figure of 100x in mind so 40x is low | 23:55 |
| Tuvix | 40x is nonsenese if we consider fatalities. | 23:55 |
| LjL | it's surreal, anyone can take any number and consider it either high or low depending on whatever they expected based on... whatever | 23:56 |
| LjL | by removing easy/free PCR access, countries like the UK and the US (but i suspect many others soon) will be removing the few actual datapoints we can use | 23:56 |
| Tuvix | The worst 7-day rate of death was during the peak of the Alpha wave 1 year ago, and that was 34x fatality (using annual flu averages.) So, close to 40, but only for 1 week. The sad part is that our peaks now are still a substantial percentage of the worst of that wave, and the last 2 waves (Delta, now Omicron) we've had vacines. | 23:56 |
| Tuvix | My understanding was that tests were still free, but I don't know how that might be changing. A big part of the annual speech Biden gave was on keeping those available, but it was short on specifics besides the 'test to treat' concept. | 23:57 |
| ecks | I don't think Sweden has been testing non-healthcare with PCR for like a month now | 23:57 |
| Tuvix | And, testing & getting treatments to those who qualify is all find and dandy, but if you at the same time tell people they don't need to bother with such protections, we have a problem: how many of those who are in need of them actually get tested in time for it to matter? | 23:58 |
| Tuvix | The Biden push for more free at-home tests also fell very short to me when I heard it; we know antigen tests have a high false-negative rate, and we also know that even the better ones really need to be taken multiple times to have any hope of a reasonably accurate result. | 23:59 |
| Tuvix | I mean, sure, it's something to show that the government is trying, but the lack of information available by agencies you'd expect to be more detailed, like the CDC and state health agencies, is utterly lacking. | 23:59 |
| Tuvix | Then again, most places in the EU that have tests also gloss over that, so this isn't a unique failing of the US specifically. | 23:59 |
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