libera/##covid-19/ Thursday, 2022-03-10

BrainstormUpdates for Malaysia: +30246 cases, +113 deaths, +266868 tests (11.3% positive) since a day ago00:00
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Mutations of #SARSCoV2 arising after treatment with Sotrovimab that induce resistanceAnd, in contrast to most monoclonal antibodies, retained efficacy of anti-Covid pills vs Omicron BA.2nejm.org/doi/full/10.10…nejm.org/doi/full/10.10… pic.twitter.com/zODFdYmiHo → https://twitter.com/EricTopol/status/150169462945595801800:07
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): IMPORTANT; WHO has reversed initial policy and now advise boosters; Effectively the C19 vaccines are a 3-dose vaccine:apnews.com/article/covid-… → https://twitter.com/Marc_Veld/status/150169700549156864700:16
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): The use of SARS-CoV-2–specific monoclonal antibodies to target a single viral epitope warrants caution because of the risk of rapid development of mutations that confer resistance after exposure to these antibodies: nejm.org/doi/full/10.10… → https://twitter.com/Marc_Veld/status/150169846279820902600:26
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol):  @bmj_latest Markedly enhanced protection vs Omicron hospitalizations for 3-dose (VE 86%) vs 2-dose (VE 65%) vaccination bmj.com/content/376/bm…"Third vaccine dose critical for protecting against Omicron variant" pic.twitter.com/P3BY0s1lmR → https://twitter.com/EricTopol/status/150170211981611008100:36
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Gey; excess deathsRed: COVID-19 deathsBlue: Vaccinations/week pic.twitter.com/B8WXmLlgsp → https://twitter.com/Marc_Veld/status/150170403870603264400:45
BrainstormUpdates for Hong Kong: +25991 cases, +291 deaths since 22 hours ago — Cook Is.: +32 cases since 23 hours ago00:59
BrainstormNew from Nature: Smriti Mallapaty: Kids show mysteriously low levels of COVID antibodies → https://www.nature.com/articles/d41586-022-00681-801:15
LjLAmong severely ill COVID-19 patients, 10.0% had dementia and 26.5% had MCI at 6 months. At 12 months, 15.0% had dementia and 26.2% had MCI, much higher than in those with milder illness (dementia, 0.8%; MCI, 5.4%) and controls (dementia, 0.7%; MCI, 5.0%). Survivors of mild or moderate COVID-19 and controls had similar incidences of dementia and MCI at both 6 and 12 months.01:19
LjLhttps://www.cidrap.umn.edu/news-perspective/2022/03/mental-decline-seen-older-covid-patients-1-year-later01:19
LjLoh, bunch of quits01:19
xxLjL: tor server down01:22
xxback up01:22
LjLicy01:23
xxit's been happening today01:23
LjL"These findings imply that the pandemic may substantially contribute to the world dementia burden in the future."01:23
LjLPotential factors in post-COVID cognitive decline, the authors said, include long-term low oxygen levels, chronic systemic inflammation, and direct viral invasion of the brain and resultant neuronal damage.01:23
BrainstormUpdates for Australia: +36286 cases, +29 deaths since 22 hours ago — Slovakia: +14358 cases since 14 hours ago — Canada: +7202 cases, +46 deaths, +38409 tests (1.7% positive) since 22 hours ago02:02
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): US Covid hospitalizations descend to their lowest level in over 8 months, and below all but 1 of its pandemic waves pic.twitter.com/Vs6qeArL3u → https://twitter.com/EricTopol/status/150173765155188736403:01
BrainstormUpdates for South Korea: +327532 cases, +206 deaths since 23 hours ago — Vietnam: +265163 cases, +109 deaths, +188681 tests (140.5% positive) since a day ago04:01
LjLoof04:04
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Another study today from @Cornell with 52% reduced infections with booster compared with 2-shots among  college students during Omicron wave medrxiv.org/content/10.110… pic.twitter.com/uMJL82YwuL → https://twitter.com/EricTopol/status/150176726957924762204:56
BrainstormNew from Politico: Addressing harmful subsidies globally will help solve the climate and biodiversity crises: Faced with the existential threats of runaway climate change and biodiversity [... want %more?] → https://www.politico.eu/sponsored-content/climate-change-and-biodiversity-loss-are-the-twin-crises-of-our-era-reforming-agricultural-fishery-and-forestry-subsidies-could-help-solve-both/05:06
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Consider that Covid started with a ~18-fold increased mortality compared with influenza for people age 60+ pic.twitter.com/Pq4MAsuzn8 → https://twitter.com/EricTopol/status/150177321399027302405:25
TuvixAnother data point I found notable in the CDC weekly update this week of provisional deaths broken down by age-group: starting with Delta, at every point since in the US, the under-50's have been roughly equal to or worse in monthly death figures for every age-group under 50. That is, if you're under-50, your age-group is dying at higher rates each month than before vaccines were available.05:46
TuvixPercentages of the peaks of each wave by age, using percentages of the *alpha* peak: 0-17 y/o: Delta: 214%, Omicron: 196%. 18-29 y/o: Delta: 209%, Omicron: 129%. 30-39 y/o: Delta: 237%, Omicron: 114%. 40-49 y/o: Delta: 192%, Omicron: 110%05:52
TuvixDelta was quite bad in all of these groups, nearly at or over twice as bad in terms of deaths. Omicron is also at least as bad as Alpha in all of them, ranging from slightly worse for peak fatality rates to nearly twice as bad as pre-vaccine Alpha was.05:53
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: For employers planning reopening, experts suggest planning for long COVID-19: The condition can be tough to detect and affected employees may be unaware they have long COVID-19, which complicates matters for [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/taqtls/for_employers_planning_reopening_experts_suggest/05:53
BrainstormUpdates for Germany: +262785 cases since 23 hours ago06:06
BrainstormUpdates for Saxony, Germany: +16679 cases, +11 deaths since a day ago — Mecklenburg-Vorpommern, Germany: +8291 cases, +12 deaths since a day ago — Saxony-Anhalt, Germany: +8200 cases, +5 deaths since a day ago — Kedah, Malaysia: +3179 cases, +12 deaths since a day ago07:02
BrainstormNew from MedicineNet: (news): In Reversal, WHO Now Supports COVID Boosters → http://www.medicinenet.com/script/main/art.asp07:28
BrainstormNew from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): RoActemra, tocilizumab, Arthritis, Rheumatoid;Arthritis, Juvenile Rheumatoid;Cytokine Release Syndrome;Giant Cell Arteritis;COVID-19 virus infection, Date of authorisation: 15/01/2009, Revision: 37, [... want %more?] → https://www.ema.europa.eu/en/medicines/human/EPAR/roactemra08:54
BrainstormUpdates for New Zealand: +21053 cases, +16 deaths since a day ago09:02
BrainstormNew from r/Coronavirus: Daily Discussion Thread | March 10, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/tattpe/daily_discussion_thread_march_10_2022/09:03
BrainstormNew from Reddit (test): CoronavirusUK: The Guardian: UK Covid cases rising among those aged 55 and over → https://old.reddit.com/r/CoronavirusUK/comments/tauegm/the_guardian_uk_covid_cases_rising_among_those/10:39
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): We are not there yet though: the circulation of SARS-CoV-2 remains much higher than Influenza during flu season, and smaller % x large numbers = large numbers! pic.twitter.com/qEa6JU4kap → https://twitter.com/Marc_Veld/status/150185748150875750410:59
BrainstormNew from WHO Euro: Putting health at the centre of post-COVID recovery: WHO European Region faces stark choices that will shape its future: Given the far-reaching impacts of the COVID-19 [... want %more?] → https://www.euro.who.int/en/media-centre/sections/press-releases/2022/putting-health-at-the-centre-of-post-covid-recovery-who-european-region-faces-stark-choices-that-will-shape-its-future11:28
BrainstormNew from WHO Euro: Access to vaccination for refugees from Ukraine needed to protect the most vulnerable among them from vaccine-preventable diseases: Protecting the health of all, [... want %more?] → https://www.euro.who.int/en/countries/israel/news/news/2022/3/access-to-vaccination-for-refugees-from-ukraine-needed-to-protect-the-most-vulnerable-among-them-from-vaccine-preventable-diseases11:37
BrainstormNew from BMJ: Increasing vaccine uptake . . . and other stories: Vaccine hesitancyJournalists and politicians use the phrase “vaccine hesitancy” to explain why people remain un-immunised despite plentiful supplies of vaccine. The term misleadingly implies that... → http://www.bmj.com/content/376/bmj.o558.short11:47
BrainstormUpdates for Brunei: +3849 cases, +1 deaths since a day ago12:03
zutt%cases Finland12:04
Brainstormzutt: Finland has had 703052 confirmed cases (12.7% of all people) and 2573 deaths (0.4% of cases; 1 in 2148 people) as of 23 hours ago. 10.1 million tests were done (1.8 per capita, 7.0% positive). 4.4 million were vaccinated (78.7%). See https://offloop.net/covid19/?default=Finland&legacy=no12:04
zutt12.7%.. damn12:04
BrainstormNew from BMJ: We cannot afford to repeat these four pandemic mistakes: As a physician, one of the hardest parts of the covid-19 pandemic was watching patients get steadily sicker and often die. At the bedside, we see past the numbers dispassionately presented on data... → http://www.bmj.com/content/376/bmj.o631.short12:16
BrainstormNew from ProPublica: Shackles and Solitary: Inside Louisiana’s Harshest Juvenile Lockup: by Annie Waldman , ProPublica; Beth Schwartzapfel , The Marshall Project ;  and Erin Einhorn , NBC News ProPublica is a nonprofit newsroom that investigates abuses of power. [... want %more?] → https://www.propublica.org/article/shackles-and-solitary-inside-louisianas-harshest-juvenile-lockup#127586312:35
BrainstormNew from COVID on Twitter: John Burn-Murdoch (@jburnmurdoch): So to summarise Covid in England in March 2022:• 40x less lethal than Jan 2021, now less lethal than flu• But spreads very efficiently, and we’re also doing more mixing• So Covid still adding to overall mortality risk, but it’s now only [... want %more?] → https://twitter.com/jburnmurdoch/status/150188651200640614512:54
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 10MAR22 → https://old.reddit.com/r/nCoV/comments/tax254/global_covid_cases_for_10mar22/13:03
BrainstormUpdates for United Kingdom: +1787 cases since 17 hours ago13:06
BrainstormNew from COVID on Twitter: Colin Angus (@VictimOfMaths): This also looks like good news - the recent increase in people in English hospitals with positive COVID tests is mostly driven by patients who are being treated for something else, *not* COVID. pic.twitter.com/S617p7hudd → https://twitter.com/VictimOfMaths/status/150189056807025868913:13
BrainstormNew from COVID on Twitter: Covid Fact Check UK (@fact_covid): It’s been confirmed today that government funding will end for the Zoe study in less than a month.This is disappointing news for the team there, but they did some invaluable work, particularly in the first year of the pandemic, and should be rightly [... want %more?] → https://twitter.com/fact_covid/status/150189429577470771513:22
BrainstormNew from COVID on Twitter: Covid Fact Check UK (@fact_covid): Vaccines, infection-acquired immunity and a milder variant have helped dramatically reduced the mortality rate of COVID in England. Indeed it is lower than flu for the first time, even for the elderly.Deaths remain higher from COVID overall, because [... want %more?] → https://twitter.com/fact_covid/status/150189679384774656713:32
BrainstormNew from Reddit (test): China_Flu: SARS-CoV-2 is associated with changes in brain structure in UK Biobank → https://old.reddit.com/r/China_Flu/comments/tayr23/sarscov2_is_associated_with_changes_in_brain/14:42
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): More data that vaccines do reduce infection rates. This on a University campus:Boosters protect against SARS-CoV-2 infections in young adults during an Omicron-predominant periodmedrxiv.org/content/10.110… → https://twitter.com/Marc_Veld/status/150191741706434970714:52
de-facto%title https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.101004214:54
Brainstormde-facto: From journals.plos.org: Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-1914:54
BrainstormUpdates for Germany: +263273 cases since 23 hours ago15:05
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Without an immunity wall of adequate vaccination protection (including boosters and type of vaccine) and/or infection-acquired immunity, especially in people of advanced age, Omicron carries a very high lethality rate pic.twitter.com/lKDWDA5CdK → https://twitter.com/EricTopol/status/150192543015208140915:21
BrainstormUpdates for Canada: +7496 cases, +55 deaths since 22 hours ago16:01
BrainstormNew from r/Science: science: In Arkansas during August–October 2021, districts with universal mask requirements had a 23% lower incidence of COVID-19 among staff members and students compared with districts without mask requirements. → https://old.reddit.com/r/science/comments/tb0ab9/in_arkansas_during_augustoctober_2021_districts/16:09
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Some potential insights into severe COVID-19 and autoimmunity with regulatory-type CD8+ cells suppressing effector T cells.KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19science.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/150194084955011891816:28
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): As in England & Germany, cases, hospitalisations & positivity ratios in Belgium on the rise again. Probably due to combination of Omicron BA.2 & more contacts. SIMID models do not expect any big issues though, covid-en-wetenschap.github.io/2022/02/techni…. [... want %more?] → https://twitter.com/TWenseleers/status/150195238348759451017:17
BrainstormNew from ClinicalTrials.gov: (news): Early Renal Replacement Therapy in COVID 19 Patients With AKI Does it Improve the Outcome? → https://clinicaltrials.gov/ct2/show/NCT0527468517:38
BrainstormNew from ClinicalTrials.gov: (news): Safety and Immunogenicity of Prime-boost Vaccination of SARS-CoV-2 in Patients With Cancer → https://clinicaltrials.gov/ct2/show/NCT0527354117:49
BrainstormNew from ClinicalTrials.gov: (news): The Immunogenicity and Safety of V-01-351/V-01D Bivalence Vaccine → https://clinicaltrials.gov/ct2/show/NCT0527352817:58
BrainstormUpdates for Netherlands: +74518 cases, +41 deaths since 14 hours ago18:06
BrainstormNew from ClinicalTrials.gov: (news): Add-on Study on Solidarity Trial Plus in Nepal → https://clinicaltrials.gov/ct2/show/NCT0527324218:08
BrainstormNew from COVID on Twitter: Derek Lowe (@Dereklowe): Delivering mRNA (either as a vaccine or a therapy) is a long way from being a well-solved problem. There's a huge landscape of possible formulations, and small changes can led to totally different outcomes. The discovery rush is on, for sure!science.org/content/blog-p… → https://twitter.com/Dereklowe/status/150196840742778880318:18
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): This is what's needed and how you do it"We have developed and delivered a rapid, near real-time data-monitoring framework for the roll-out of antivirals and monoclonal antibodies in England"medrxiv.org/content/10.110… @bengoldacre and colleagues pic.twitter.com/yvgouZjyN0 → https://twitter.com/EricTopol/status/150197089127768474918:27
BrainstormNew from BBC Health: UK Covid inquiry draft terms of reference set out: The probe will look at areas including preparedness and the public health response to the pandemic. → https://www.bbc.co.uk/news/uk-6069709318:47
BrainstormUpdates for Italy: +55156 cases, +136 deaths, +453341 tests (12.2% positive) since a day ago19:09
BrainstormNew from r/COVID19: COVID19: An epidemic of uncertainty: rumors, conspiracy theories and vaccine hesitancy → https://old.reddit.com/r/COVID19/comments/tb4u9j/an_epidemic_of_uncertainty_rumors_conspiracy/19:25
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Evusheld doses go unused, despite demand in vulnerable patients - fully 80% of the drug’s supply is languishing on shelves while physicians remain uninformed or uncertain about the drug and its guidance, → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/tb573e/evusheld_doses_go_unused_despite_demand_in/19:35
BrainstormNew from Ars Technica: Science: COVID ups risks of dementia, cognitive impairment, and decline in older survivors → https://arstechnica.com/?p=184012319:54
BrainstormUpdates for United Kingdom: +85879 cases, +142 deaths since 23 hours ago — Canada: +64 deaths since 23 hours ago19:59
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): An exceptional new review of what we know about the immunology of Covid and #LongCovid @ScienceMagazine w/ @ScienceVisuals @MiriamMerad @stanfordimmuno @EFIS_Immunology @VirusesImmunity and graphics @oooitsplasma science.org/doi/10.1126/sc… pic.twitter.com/yruhAfe5Mb → https://twitter.com/EricTopol/status/150199655534757068820:04
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The new special issue @ScienceMagazine is rich with information and reviews on Covidscience.org/toc/science/cu… pic.twitter.com/OU7z1moxNM → https://twitter.com/EricTopol/status/150199724445460481520:13
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The Covid vaccine road aheadscience.org/doi/10.1126/sc… by @Daltmann10 and Rosemary Boyton@ScienceMagazine pic.twitter.com/2VzBtahsQc → https://twitter.com/EricTopol/status/150200634021802393720:42
BrainstormUpdates for Tonga: +100 cases since a day ago — Samoa: +4 cases since 2 days ago21:02
BrainstormNew from r/COVID19: COVID19: Mathematical Modeling for Removing Border Entry and Quarantine Requirements for COVID-19, Vanuatu → https://old.reddit.com/r/COVID19/comments/tb7rkm/mathematical_modeling_for_removing_border_entry/21:33
BrainstormNew from StatNews: Listen: Gilead’s growing pains, Covid’s origins, & Theranos as prestige TV: Dive into the 200th episode of "The Readout LOUD" #podcast: Can biotech companies age gracefully? Where did Covid-19 come from? And does Theranos make for good television? We cover all… → https://www.statnews.com/2022/03/10/podcast-gilead-growing-pains-covid-origins-theranos-tv/21:42
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A first-rate review of #SARSCoV2 epidemiology @ScienceMagazine by @KatiaKoelle @m_a_martin @B_Lopman @nataliexdean @EmoryRollins science.org/doi/10.1126/sc… "evolutionary theory has pointed out that we should not expect evolution toward lower virulence" pic.twitter.com/bP1m7aJwTZ → https://twitter.com/EricTopol/status/150202475886238518222:02
BrainstormUpdates for Malaysia: +30787 cases, +70 deaths since 22 hours ago — Germany: +76618 cases since 16 hours ago — Spain: +22615 cases, +85 deaths since a day ago — Canada: +3656 cases, +64 deaths since 23 hours ago22:10
BrainstormNew from CIDRAP: Study: Third COVID mRNA vaccine dose needed against Omicron: Mary Van Beusekom | News Writer | CIDRAP News Mar 10, 2022 Protection against hospital illness was 85% for 2 doses against Alpha and Delta and 86% for 3 doses against Omicron. → https://www.cidrap.umn.edu/news-perspective/2022/03/study-third-covid-mrna-vaccine-dose-needed-against-omicron22:12
BrainstormNew from r/COVID19: COVID19: Hesitant but vaccinated: assessing COVID-19 vaccine hesitancy among the recently vaccinated → https://old.reddit.com/r/COVID19/comments/tb972o/hesitant_but_vaccinated_assessing_covid19_vaccine/22:32
BrainstormNew from CIDRAP: COVID-19 remains high in UK as BA.2 gains ground: Lisa Schnirring | News Editor | CIDRAP News Mar 10, 2022 In the US, lawmakers scramble to find funding for COVID-19 activities. → https://www.cidrap.umn.edu/news-perspective/2022/03/covid-19-remains-high-uk-ba2-gains-ground23:01
jephhh12[m]hi23:10
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): "The question is how far society wants to go to reduce them [burden of respiratory diseases]. Instead of calling for a return to normal, we should be asking if normal can't be better."—@chrischirp science.org/doi/10.1126/sc…@ScienceMagazine And not just about [... want %more?] → https://twitter.com/EricTopol/status/150204163807543706223:11
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): “Back to normal” is not enoughAs the world reflects on 2 years of the COVID-19 pandemic, we need to change how to tackle the enormous challenges of the future. science.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/150204613459175833923:21
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): The changing epidemiology of SARS-CoV-2We have come a long way in understanding the complex and changing dynamics of SARS-CoV-2, mathematical modeling and quantitative analyses of empirical data have played key roles.science.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/150204702438398771223:30

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