| MerlinMp[m] | wakeup: | 00:03 |
|---|---|---|
| Brainstorm | Updates for Germany: +56228 cases, +109 deaths since 17 hours ago | 00:09 |
| user__ | you can take 3000mg para/day ; its liver metabolized; not really used for self-harm | 00:21 |
| user__ | symptomatic pain& fever short-term relief | 00:22 |
| LjL | user__, 3000mg/day is an upper boundary afaik, and indeed it's liver-metabolized and an overdose will damage the liver... please don't say "you can take" about something like that, we do not give direct medical advice in this channel | 00:24 |
| LjL | you can take whatever your doctor tells you to take and/or what the medication's instructions say | 00:24 |
| user__ | actually 4000 is | 00:24 |
| user__ | whatever | 00:25 |
| LjL | whatever indeed | 00:25 |
| LjL | this guy has just been posting random stuff for all i've seen | 00:26 |
| LjL | anyway as to use for self-harm https://pubmed.ncbi.nlm.nih.gov/9196648/ | 00:26 |
| LjL | " Paracetamol is now the most common drug used for self-poisoning in the UK and is associated with potentially fatal liver damage" https://pubmed.ncbi.nlm.nih.gov/8770427/ | 00:27 |
| Brainstorm | New from COVID on Twitter: Theo Sanderson (@theosanderson): @PeacockFlu @MickieThePoet @Unusual_Times (and they're more being categorised as B.1.1.529 than they are as B, but we don't pull out "B.1.1.529" with the default selection (just BA.1 and BA.2)) → https://twitter.com/theosanderson/status/1506048972871417859 | 00:33 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): @TheLancetEndo The ~40% increased risk of diabetes, in people with Covid, not present at 1 month, but manifest at 1-year follow-upthelancet.com/journals/landi… among 180,000 infectees vs 4.3 million controls #LongCovid @zalaly pic.twitter.com/ziNYLnnBzR → https://twitter.com/EricTopol/status/1506067380820070401 | 01:48 |
| LjL | :( | 01:56 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Editorial "The long-term implications of #SARSCoV2 infectionincreasing diabetes risk are profound."thelancet.com/journals/landi… @kmvnarayan14@LisaStaimezand by @zalaly twitter.com/zalaly/status/… → https://twitter.com/EricTopol/status/1506070638447923202 | 01:58 |
| Brainstorm | Updates for Canada: +3388 cases, +74472 tests since 8 hours ago | 02:02 |
| Brainstorm | New from ##covid-19 Zotero group: Rising diabetes diagnosis in long COVID: Type Journal Article Author K. M. Venkat Narayan Author Lisa R. Staimez URL https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00078-X/fulltext Publication The Lancet Diabetes & Endocrinology ISSN 2213-8587, 2213-8595 Date [... want %more?] → https://www.zotero.org/groups/covid_links/items/FH36NZGW | 02:07 |
| LjL | de-facto, does this https://www.webmd.com/lung/news/20220228/newly-diagnosed-diabetes-in-covid-patients-often-temporary-study# seem plausible, in the face of several studies (see above, it's an editorial, it links to a few) where COVID recovered are matched to controls in a presumably careful way? | 02:24 |
| LjL | (as in: i'd hope they test the sugar levels of both!) | 02:24 |
| Brainstorm | New from ##covid-19 Zotero group: Incidence of newly diagnosed diabetes after Covid-19: Type Journal Article Author Wolfgang Rathmann Author Oliver Kuss Author Karel Kostev URL https://doi.org/10.1007/s00125-022-05670-0 Publication Diabetologia ISSN 1432-0428 Date 2022-03-16 Journal Abbr Diabetologia DOI [... want %more?] → https://www.zotero.org/groups/covid_links/items/K6G8KVNM | 02:26 |
| Brainstorm | New from Reddit (test): China_Flu: Potentially Reduced Brain Immunity Caused by Pfizer Vaccine (Polish In-vitro Study Preprint) (Dr. Syed) → https://old.reddit.com/r/China_Flu/comments/tjrind/potentially_reduced_brain_immunity_caused_by/ | 02:36 |
| LjL | didn't know they made preprints as videos | 02:37 |
| Brainstorm | New from ##covid-19 Zotero group: Newly diagnosed diabetes vs. pre-existing diabetes upon admission for COVID-19: Associated factors, short-term outcomes, and long-term glycemic phenotypes: Type Journal Article Author Sara J. Cromer Author Caitlin Colling Author Daria Schatoff Author Michael Leary Author Maria I. [... want %more?] → https://www.zotero.org/groups/covid_links/items/I77EDRDD | 02:46 |
| LjL | what does "excess burden" mean in statistics/epidemiology? | 02:54 |
| Brainstorm | New from COVID on Twitter: Alessandro Sette (@SetteLab): Another great collaboration between our groups at LJI. The large vaccination efforts represents a unique opportunity to analyze immune responses to different platforms, in a longitudinal fashion. The results will inform future vaccine design vaccination and [... want %more?] → https://twitter.com/SetteLab/status/1506084936184320003 | 02:55 |
| LjL | i hate that these studies on pretty terrible consequences of COVID don't generally include vaccination status | 02:59 |
| LjL | (either because they're based on older case sets, or because they don't have the data, i guess) | 02:59 |
| LjL | i'd *really* want to know how vaccination affects, say, risk of diabetes or dementia after COVID | 02:59 |
| Brainstorm | Updates for United Kingdom: +739 cases since 6 hours ago | 03:05 |
| Brainstorm | New from ##covid-19 Zotero group: Risks and burdens of incident diabetes in long COVID: a cohort study: Type Journal Article Author Yan Xie Author Ziyad Al-Aly URL https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00044-4/fulltext Publication The Lancet Diabetes & Endocrinology ISSN 2213-8587, [... want %more?] → https://www.zotero.org/groups/covid_links/items/DNNARUDZ | 03:14 |
| Brainstorm | Updates for New Zealand: +20954 cases, +14 deaths since 3 hours ago | 04:01 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Large cohort study of US vets finds incr. risk (HR 1·4, 95% CI 1·36–1·44) of incident diabetes in C19 survivorsRisks+burdens increased acc to severity of the acute phase“Post-acute COVID-19 care should involve identification and management of [... want %more?] → https://twitter.com/GANyborg/status/1506108846900711427 | 04:30 |
| Brainstorm | New from r/COVID19: COVID19: SARS-CoV-2 Omicron spike H655Y mutation is responsible for enhancement of the endosomal entry pathway and reduction of cell surface entry pathway → https://old.reddit.com/r/COVID19/comments/tjtp8e/sarscov2_omicron_spike_h655y_mutation_is/ | 04:58 |
| Brainstorm | New from COVID on Twitter: Josiah 'So Mild' Grindrod (@JT_Grindrod): The vaccinated and boosted will be paying a price for resuming pre pandemic normal. Not the price you're thinking of, but they'll pay it, and it will be steep. twitter.com/DrLeanaWen/sta… → https://twitter.com/JT_Grindrod/status/1506129300755415040 | 05:45 |
| Brainstorm | New from Reddit (test): Covid2019: Long COVID Symptoms, Risks & Unknowns: ‘New Public Health Dilemma’: In these 144 people, we found that they still have pieces of the original virus in their white blood cells, so is that it? We can't say for sure, but this could be a clue, → https://old.reddit.com/r/Covid2019/comments/tjv7pt/long_covid_symptoms_risks_unknowns_new_public/ | 05:55 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): A new (excellent) study is the first to fairly compare Novavax with the 3 FDA-approved vaccines. And does it not only for neut abs, but also CD4+ and CD8+ T cells. Results at 6mo:NAbs: Mod > Pfi ~ Nov > JJ ~ infectnCD4: Nov ~ Mod > Pfi ~ JJ ~ [... want %more?] → https://twitter.com/michaelzlin/status/1506138625980858373 | 06:23 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: New study finds higher rates of newly diagnosed type 2 diabetes after infection with mild COVID-19 → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/tjvorg/new_study_finds_higher_rates_of_newly_diagnosed/ | 06:33 |
| gry | is the sentiment at https://twitter.com/COVIDnewsfast/status/1505894436001095682 valid? | 06:45 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): - Novavax CD8 response is clearly lower than the others. This is not surprising as there is no expression of spike from within host cells, so MHC-I presentation (to train CD8+ CTLs) has to occur in antigen-presenting cells via endosomal uptake and cross-presentation. → https://twitter.com/michaelzlin/status/1506144520433397760 | 06:52 |
| Brainstorm | New from MedicineNet: (news): COVID-19 Led to Dangerous Delays in Care for Women With Gynecologic Cancers → http://www.medicinenet.com/script/main/art.asp | 07:02 |
| Brainstorm | Updates for Western Australia, Australia: +7036 cases, +1 deaths since a day ago — Jilin, China: +1542 cases since a day ago — Cook Is.: +92 cases since 2 days ago — Cook Islands, New Zealand: +92 cases since a day ago | 07:03 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): @profshanecrotty Excellent study. Any plans to look at NAb levels against BA.1 or BA.2? → https://twitter.com/michaelzlin/status/1506164584364707841 | 08:08 |
| Brainstorm | New from StatNews: Opinion: Checklists work well for complicated health care problems. But they don’t work to solve complex ones, like pandemics: Federal health officials did many good things in response to Covid-19, but they misdiagnosed the nature of the pandemic: They deemed it a [... want %more?] → https://www.statnews.com/2022/03/22/covid-complex-problem-not-complicated-problem/ | 09:53 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Several months after initial disease- 7/10 LC patientsreported concentration/memory problems- 1/2 had had difficulty getting medical professionals take their symptoms seriouslyNow, without PCR tests/confirmed C19 diagnosis, how many will be [... want %more?] → https://twitter.com/GANyborg/status/1506194173522857988 | 10:03 |
| Brainstorm | New from BMJ: The limitations of scientific evidence when speaking truth to politics: The decision by Prime Minister Boris Johnson to end covid-19 restrictions was clearly political. The imposition of public health restrictions is, should be, and can only be through politics.... → http://www.bmj.com/content/376/bmj.o732.short | 11:00 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Israel: Health Ministry experts back 4th COVID vaccine dose for over-18s → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/tk009j/israel_health_ministry_experts_back_4th_covid/ | 11:39 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pfizer inks deal with UNICEF to supply Covid pill to poor countries, but advocates say it isn’t enough → https://www.statnews.com/pharmalot/2022/03/22/pfizer-unicef-covid19-merck-patents-who/ | 11:58 |
| wakeup | paracetamol and ibuprofen really help | 12:59 |
| wakeup | if I don't take them every once in 6 hours, I get cold and start to feel worse | 12:59 |
| wakeup | well, they don't cure it, but they help with pain, as we said | 13:03 |
| wakeup | i mean fever | 13:04 |
| wakeup | and pain too | 13:04 |
| peetaur | does it help with fever, or prevent fever doing its job? Just like your usual virus, elevated temperature inhibits replication... https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001065 | 13:25 |
| peetaur | generally elevated temperature is only suppressed if it's out of control... | 13:25 |
| * pwr22 uploaded an image: (101KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/TwTMxNNdkMYRAKWegXAXvMCz/image.png > | 13:26 | |
| peetaur | I hope you have consulted with a qualified medical professional about these things | 13:26 |
| pwr22 | LjLde-facto: ^ UK continues to go in the wrong direction | 13:26 |
| Brainstorm | New from Reddit (test): Global COVID Cases For 22MAR22: Summary As Of: 22MAR @ 12:19 GMT Countries 225 + 2 Cases 472,803,005 Deaths 6,106,746 Recovered 409,106,338 Active Cases 57,589,921 Countries reporting new cases: 85 Countries reporting new deaths: 48 Countries reporting increased Active [... want %more?] → https://old.reddit.com/r/nCoV/comments/tk1xcu/global_covid_cases_for_22mar22/ | 13:34 |
| wakeup | my mother is quite stupid... she has like the symptoms and didn't go to the pharmacy to take the test, now we have covid, and we still don't know if she has covid because she still didn't take the test... Once I know my brother had the covid, I immediately took the test... I don't understand certain people, starting from her | 13:44 |
| wakeup | no responsibility | 13:47 |
| dTal | LjL: that twitter thread is scary, everyone saying there a big spike of people getting it for the first time this week | 13:48 |
| wakeup | also, not sure who is more stupid: my mother or the governments that made the use of masks not mandatory | 13:52 |
| wakeup | probably governments | 13:52 |
| wakeup | that's really stupid | 13:52 |
| wakeup | as if covid had disappeared, they decided to make the use of masks not mandatory | 13:53 |
| wakeup | how stupid is that | 13:53 |
| Brainstorm | New from Reddit (test): nCoV: Military Doctor Testifies in Court: High-Level Command Ordered Her Silence Over Frightening Vaccine Data | 21MAR22 → https://old.reddit.com/r/nCoV/comments/tk28nv/military_doctor_testifies_in_court_highlevel/ | 13:53 |
| wakeup | but still less stupid than the war in ukraine | 13:54 |
| Brainstorm | Updates for Laos: +2328 cases, +2 deaths since a day ago | 14:02 |
| Brainstorm | New from Contagion Live: Omicron COVID-19 Variant Spread to 25% of Household Members, Norwegian Study Shows: The Omicron variant of SARS-CoV-2 had a secondary attack rate of 25.1% in Norwegian households compared with 19.4% for the Delta variant. → https://www.contagionlive.com/view/omicron-covid-19-variant-spread-to-25-of-household-members-norwegian-study-shows | 14:02 |
| Brainstorm | New from BMJ: The US shouldn't settle for its current number of covid deaths or vaccination rates: The US is moving into a new phase of the covid-19 pandemic. Some are calling this the endemic phase but I would urge us to consider what this word means and if we are there yet. Endemic does not mean... → http://www.bmj.com/content/376/bmj.o763.short | 14:12 |
| Brainstorm | New from COVID on Twitter: (translated) Florian Krammer (@florian_krammer): 3)...you could certainly prevent a proportion of the deaths with it. Incidentally, there is also an antibody cocktail that prophylactically protects people with immunodeficiency from COVID-19. Calls itself Evusheld, but is unfortunately [... want %more?] → https://twitter.com/florian_krammer/status/1506265468054777867 | 14:51 |
| Brainstorm | Updates for Vanuatu: +92 cases since 21 hours ago — Canada: +5215 cases since 22 hours ago | 15:05 |
| ZdrytchX | .cases australia | 15:08 |
| Brainstorm | ZdrytchX: Australia has had 4.0 million confirmed cases (15.6% of all people) and 5763 deaths (0.1% of cases; 1 in 4452 people) as of 6 hours ago. 65.5 million tests were done (2.6 per capita, 6.1% positive). 20.5 million were vaccinated (79.8%). +23251 cases since 7 hours ago. See https://offloop.net/covid19/?default=Australia&legacy=no | 15:09 |
| Brainstorm | New from r/COVID19: COVID19: Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoring → https://old.reddit.com/r/COVID19/comments/tk3s7f/template_switching_and_duplications_in_sarscov2/ | 15:11 |
| Brainstorm | New from StatNews: Opinion: Covid-19 vaccine policy should be made by public health experts, not company executives: What is now happening recapitulates some of the events of last summer and fall, when company executives drove the narrative that a third mRNA vaccine dose was [... want %more?] → https://www.statnews.com/2022/03/22/pharma-executives-shouldnt-drive-covid-19-vaccine-policy/ | 15:59 |
| Brainstorm | Updates for Spain: +54147 cases, +346 deaths since 3 days ago — Tonga: +366 cases, +12277 tests since 23 hours ago | 16:01 |
| Brainstorm | New from r/COVID19: COVID19: GP wellbeing during the COVID-19 pandemic: a systematic review → https://old.reddit.com/r/COVID19/comments/tk5b0m/gp_wellbeing_during_the_covid19_pandemic_a/ | 16:29 |
| Brainstorm | New from ClinicalTrials.gov: (news): Long COVID19 Fatigue and Obstructive Sleep Apnoea → https://clinicaltrials.gov/ct2/show/NCT05290350 | 16:48 |
| Brainstorm | New from ClinicalTrials.gov: (news): Evaluation of Postmortem Pulmonary Interstitial Fibrosis Severity and EGFR Positivity in Covid-19 Pneumonia → https://clinicaltrials.gov/ct2/show/NCT05290441 | 17:07 |
| Brainstorm | Updates for Germany: +151467 cases, +198 deaths since 17 hours ago | 17:10 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): There are many tragedies in this epidemic, but the major intellectual one is that "following the science" has been turned by some public health officials into "that's why we're not doing anything" → https://twitter.com/michaelzlin/status/1506302342987014145 | 17:17 |
| Brainstorm | New from COVID on Twitter: Baric Laboratory (@Baric_Lab): We need more oral #antivirals to treat #COVID19. Here we show nucleoside prodrug therapy can improve #SARSCoV2 disease in mice. @David_RMartinez @aschaefe29 @timothysheahan @UNCResearch @UNCpublichealth @ScienceTM science.org/doi/10.1126/sc… → https://twitter.com/Baric_Lab/status/1506304858411962369 | 17:27 |
| Brainstorm | Updates for Netherlands: +40534 cases, +24 deaths since 13 hours ago | 18:00 |
| Brainstorm | New from Reddit (test): Tuesday 22 March 2022 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://old.reddit.com/r/CoronavirusUK/comments/tk755s/tuesday_22_march_2022_update/ | 18:06 |
| Brainstorm | New from r/COVID19: COVID19: Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice → https://old.reddit.com/r/COVID19/comments/tk7xq7/therapeutic_treatment_with_an_oral_prodrug_of_the/ | 18:25 |
| Brainstorm | New from WebMD: Alcohol-Related Deaths Spiked During First Year of Pandemic: Study: The number of Americans who died from alcohol-related causes increased dramatically during the first year of the pandemic, according to a new study published in the Journal of the American Medical Association. → https://www.webmd.com/lung/news/20220322/alcohol-related-deaths-spike-first-year-pandemic | 18:35 |
| -Bridgestorm- ⭕ 地震! Earthquake! 6.2 M tremor, with 3 reports, 1 early, occurred 8 minutes ago (17:41:00 UTC), during a gibbous moon night, Hualien City, Taiwan (23.61, 121.59) ± 32 km, ↓18 km likely felt 310 km away (in 花蓮市, 吉安鄉, 光復鄉, 壽豐鄉, 鳳林鎮, 瑞穗鄉…) by 352700 people (api.p2pquake.net) | 18:49 | |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): With some parts of the US reaching 70% BA.2 variant and lack of increase in cases, it's a very encouraging sign so farwashingtonpost.com/health/2022/03…by @JoelAchenbach pic.twitter.com/eSoMBlI454 → https://twitter.com/EricTopol/status/1506329351553310721 | 19:04 |
| Brainstorm | Updates for Singapore: +13166 cases, +6 deaths since a day ago | 19:09 |
| -Bridgestorm- ⭕ 地震! Earthquake! 6.1 Ml tremor, occurred 30 minutes ago (17:43:25 UTC), during a gibbous moon night, Hualien City, Taiwan (23.46, 121.46), ↓19 km likely felt 290 km away (in 玉里鎮, 花蓮市, 瑞穗鄉, 吉安鄉, 光復鄉, 鳳林鎮…) by 367100 people (www.seismicportal.eu) | 19:14 | |
| wakeup | I try to resist this time not to take parecetamol, but I definitely need to take it before going to sleep, otherwise i can't sleep | 19:21 |
| wakeup | the effect is roughly 6 hours | 19:21 |
| ublx | saving it to help with sleep is a good strategy | 19:22 |
| LjL | Yeah | 19:24 |
| LjL | How much do you take? | 19:24 |
| LjL | wakeup: you should take ibuprofen with food by the way, it can be really hard on the stomach | 19:27 |
| -Bridgestorm- ⭕ 地震! Earthquake! 6.8 M tremor, registered by PT,quakenotices, occurred 44 minutes ago (17:41:36 UTC), during a gibbous moon night, Hualien City, Taiwan (23.32, 121.62) ± 2 km, ↓5 km likely felt 450 km away (in 玉里鎮, 長濱鄉, 成功鎮, 瑞穗鄉, 富里鄉, 光復鄉…) by 166100 people → https://t.co/jaJFHeE8p2 (Twitter) | 19:27 | |
| LjL | For paracetamol that shouldn't matter | 19:27 |
| LjL | Which thread dTal | 19:28 |
| wakeup | today, I took in the morning and then at midday | 19:28 |
| wakeup | I should take one now too | 19:28 |
| wakeup | and then before going to sleep | 19:28 |
| wakeup | i mean, last time I was in hospital, the doctor prescribed 4 times | 19:28 |
| wakeup | but it wasn't for the covid | 19:28 |
| LjL | wakeup: well you're going to know what bothers you, just know that in general, paracetamol doesn't tend to have many side effects but overdosing is nasty. Ibuprofen can have more side effects immediately, especially on the stomach. Of course if they give you things with different guidelines while in hospital it's because it's warranted, but when self-medicating, best to be careful | 19:30 |
| Brainstorm | New from Politico: White House press secretary tests positive for COVID-19, will skip Biden’s Europe trip: President Biden tested negative for Covid-19 on Tuesday, Psaki said, and she decided to share the news of her positive test result "out of an abundance of transparency." → https://www.politico.com/news/2022/03/22/psaki-tests-positive-covid-19-00019327 | 19:33 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): If there's no US BA.2 wave, which may be shaping up, the 2nd booster becomes less of an issue. It likely has shorter duration of protection than the 1st booster (<-way too low % in age 60+) and can be deferrednytimes.com/article/4th-co… by @KnvulS w/ [... want %more?] → https://twitter.com/EricTopol/status/1506338082894712833 | 19:43 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A very helpful @ASPRgov resource to locate the limited supply of Paxlovid and monoclonal antibodies effective vs the Omicron lineages…rapeutics-locator-dhhs.hub.arcgis.com @HHS_ASPR pic.twitter.com/QMFAOxXtqY → https://twitter.com/EricTopol/status/1506341182791557128 | 19:53 |
| Brainstorm | Updates for Italy: +96904 cases, +197 deaths, +641896 tests since a day ago — United Kingdom: +95036 cases, +249 deaths since 23 hours ago | 19:59 |
| Brainstorm | New from Contagion Live: COVID-19 Vaccine Effectiveness Wanes Rapidly Against Omicron Variant: COVID-19 vaccines were less protective against symptomatic infection from the Omicron COVID-19 variant than the Delta variant. → https://www.contagionlive.com/view/covid-19-vaccine-effectiveness-wanes-rapidly-against-omicron-variant | 20:02 |
| LjL | %ocr https://pbs.twimg.com/media/FOcMuJjXwAU0e-Z?format=jpg&name=medium | 20:03 |
| Brainstorm | LjL, It says: potential baseline differences.” Most strikingly, individuals that experienced no or only mild symptoms with Covid-19 displayed specifically significant changes, but cortical damage seems to occur regardless of disease severity, age, sex, or vaccination status. It may be years before the long-term consequences of these structural differences are fully understood. | 20:04 |
| LjL | :( | 20:04 |
| LjL | %print https://twitter.com/WmHaseltine/status/1505972833498849290 | 20:04 |
| Brainstorm | LjL, It says: William Haseltine (@WmHaseltine): "Thanks to a new study from the UK we are now beginning to uncover the effects of SARS-CoV-2 infections in the brain. This study documents significant cortical gray matter loss, equivalent to nearly 10 years of aging. [... want %more?] | 20:04 |
| LjL | actually though the article says "The effect of vaccination status not yet been investigated." | 20:05 |
| LjL | well he's wrong | 20:11 |
| LjL | the actual study says | 20:11 |
| LjL | For those cases, no distinction is possible at present to determine whether a positive test is due to infection or vaccination, so potential cases identified only through lateral flow test in vaccinated participants were not included in this study. Information | 20:11 |
| LjL | on the vaccination status (except for those identified through lateral | 20:11 |
| LjL | flow test), and how both vaccination dates might interact with the date of infection, is also currently unavailable." | 20:11 |
| LjL | and that's the only mention the study makes of vaccination | 20:11 |
| de-facto | which is that study? | 20:11 |
| LjL | so he probably copied a version of the Forbes article about this study where they were wrong and now it's been corrected to say that vaccination status was not assessed | 20:12 |
| LjL | de-facto, https://www.nature.com/articles/s41586-022-04569-5 | 20:12 |
| Brainstorm | New from CIDRAP: COVID-19 in pregnancy tied to poor maternal outcomes, preterm birth, fetal death: Mary Van Beusekom | News Writer | CIDRAP News Mar 22, 2022 One study finds a doubled risk of severe maternal outcomes, and the other details placenta damage. → https://www.cidrap.umn.edu/news-perspective/2022/03/covid-19-pregnancy-tied-poor-maternal-outcomes-preterm-birth-fetal-death | 20:12 |
| LjL | and https://www.forbes.com/sites/williamhaseltine/2022/03/21/a-case-of-shrunken-brains-how-covid-19-may-damage-brain-cells/ is the article about it that was (mis)quoted | 20:13 |
| LjL | we have long known that study as a preprint https://www.medrxiv.org/content/10.1101/2021.06.11.21258690v3 | 20:16 |
| de-facto | :(( | 20:17 |
| de-facto | we just ended most measures aiming at cutting down transmission pathways | 20:18 |
| de-facto | at the highest rate of daily new infections ever | 20:18 |
| de-facto | hence we will produce such cases with the highest rate possible | 20:19 |
| LjL | Surprisingly, Douaud et al. also found additional abnormalities in regions not normally associated with the sense of smell. In particular, they observed reduced gray matter volume in some regions of the limbic system, involving several structures important for producing behavioral and emotional responses. The largest differences, ranging from 0.2% to 2% reductions, were seen in the left parahippocampal gyrus and the entorhinal cortex. These regions play an | 20:20 |
| LjL | important role in the hippocampal memory system, so gray matter loss could signify future memory impairments. | 20:20 |
| de-facto | "In particular, they observed reduced gray matter volume in some regions of the limbic system, involving several structures important for producing behavioral and emotional responses." <-- quite interesting | 20:22 |
| Brainstorm | New from ##covid-19 Zotero group: A Case Of Shrunken Brains: How Covid-19 May Damage Brain Cells: Type Web Page Author William A. Haseltine URL https://www.forbes.com/sites/williamhaseltine/2022/03/21/a-case-of-shrunken-brains-how-covid-19-may-damage-brain-cells/ Accessed 2022-03-22 19:14:23 Language en Abstract [... want %more?] → https://www.zotero.org/groups/covid_links/items/RI9S5QIA | 20:22 |
| dTal | LjL, the thread you pinged me over with the office all wearing respirators | 20:25 |
| de-facto | LjL, interestingly such symptoms were also mentioned in an article that speculates about that the Russian Flu was a coronavirus that induced something like long-COVID depression | 20:27 |
| de-facto | https://www-spektrum-de.translate.goog/news/russische-grippe-ausgeloest-durch-ein-coronavirus/1998340?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en-US&_x_tr_pto=wapp | 20:27 |
| LjL | dTal, ah right | 20:27 |
| LjL | dTal, i don't know many people, but i certainly hear of more people having covid than... ever | 20:28 |
| de-facto | ""The lack of concentration, the depression and anxiety are very reminiscent of what is now called long Covid symptoms," says Harald Brüssow. None of this is proof that the Russian flu was caused by OC43 – and it will be difficult to find it." | 20:28 |
| de-facto | "Another unknown today is Long Covid. "We know from historical records that survivors of the Russian flu often had to deal with psychological consequences," says Jütte. "At the time, people were talking about post-influenza depression." The "Parsons Report" states that such symptoms occurred in 9 percent of those who had previously been ill." | 20:29 |
| LjL | de-facto, uh, this article... talks about "The memory of the last pandemic" in 1889. surely the last influenza pandemic was the Spanish flu? | 20:29 |
| dTal | according to much-less-prominent goovernment statistics, 1 in 20 people had covid last week | 20:29 |
| de-facto | LjL, no they speculate about that the Russian Flu may have shown a spectrum of symptoms consistent with a zoonotic spill over event, possibly OC43 CoV | 20:32 |
| LjL | i can see that, but calling it "the last pandemic" is just wrong | 20:32 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Let's retweet this with a big change of regulation today! Anyone vaccinated can enter SA without a PCR test, unvaccinated need a negative PCR test & are offered the best vaccines in the world free of charge! What a deal to come to one of the most beautiful [... want %more?] → https://twitter.com/Tuliodna/status/1506352197126266880 | 20:32 |
| de-facto | and that there were symptoms similar to what we now call long-COVID | 20:33 |
| LjL | uhm also "Similarly, OC43, along with another human coronavirus (229E), causes about 30 percent of seasonal colds" ← as far as i know, coronaviruses causes a minority of colds, the majority being rhinoviruses | 20:34 |
| de-facto | note they did not isolate any RNA, hence speculate, but if it was OC43 it would have changed a lot in the timespan | 20:35 |
| LjL | "With regard to the long-term consequences of the virus infection, however, the current pandemic looks better than it did then. The majority of people are vaccinated - and current studies suggest that the risk of long Covid is massively reduced or even disappears completely." ← no they don't... | 20:36 |
| LjL | the analogy is interesting | 20:36 |
| LjL | and suggestive | 20:37 |
| LjL | but the article is a bit wrong in places | 20:37 |
| LjL | i'm surprised by how decent the english is, i almost wouldn't notice it's a machine translation | 20:37 |
| de-facto | its quite speculative, but could be interesting in the context of how long it took for that "Russian Influanza" to calm down and what outcomes it had for people | 20:37 |
| de-facto | hmm from that Forbes article | 20:39 |
| de-facto | "For a vast majority of people, the regenerative properties of the olfactory bulb restores the sense of smell within a few weeks or months. What about the rest of the brain? Damage to brain cells cannot be reversed. When tissues die, cerebrospinal fluid and other biomolecules fill the excess space to maintain the integrity of the brain." | 20:39 |
| de-facto | "Perhaps, this explains why neurological complications associated with long-haul Covid-19 show little improvement over time. Years of additional research are needed before the consequences of losing so much gray matter are fully understood. Identifying these changes now will help us to better support and treat what will be a growing class of people with cognitive impairments." | 20:39 |
| LjL | a growing class = virtually everyone | 20:40 |
| de-facto | shall we say "lovely" that this meme finally finds a more popular stage for getting more widely discussed? | 20:40 |
| LjL | i think there have been articles like this before, and this study is not new | 20:40 |
| LjL | people are just out of caring | 20:40 |
| de-facto | yeah we discussed the preprint here long time ago | 20:41 |
| de-facto | but i like that more people think about the impact of long-COVID on the productivity of the working age population majority | 20:42 |
| de-facto | something that i was ranting here quite often | 20:42 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The BA.2 wave in Western Europe is just starting to turn around ~ 3 weeks in, while there is no sign of increase in cases to date in the US. It's surprising, not easily explained, but gratifying to see —and hope it holds up pic.twitter.com/FYRWPCaNSd → https://twitter.com/EricTopol/status/1506353868405297154 | 20:42 |
| de-facto | if a society depends on the mental capabilities of the working age cohort, it should protect it from long-COVID damage | 20:43 |
| Brainstorm | New from COVID on Twitter: Florian Krammer (@florian_krammer): Influenza virus-like particle vaccine protects. twitter.com/DrBrianKeating… → https://twitter.com/florian_krammer/status/1506357149525581831 | 20:52 |
| de-facto | %title https://www.medrxiv.org/content/10.1101/2021.12.03.21266112v1.full-text | 20:56 |
| Brainstorm | de-facto: From www.medrxiv.org: Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity | medRxiv | 20:56 |
| de-facto | %title https://www.nature.com/articles/s41593-021-00926-1 | 20:59 |
| Brainstorm | de-facto: From www.nature.com: The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells | Nature Neuroscience | 20:59 |
| de-facto | %title https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02323-8 | 20:59 |
| Brainstorm | de-facto: From jneuroinflammation.biomedcentral.com: Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19 | Journal of Neuroinflammation | Full Text | 20:59 |
| Brainstorm | Updates for Malaysia: +21483 cases, +72 deaths since a day ago | 21:08 |
| Brainstorm | New from Novavax: (news): Novavax and Serum Institute of India Announce First Emergency Use Authorization of Novavax' COVID-19 Vaccine in Adolescents ≥12 to <18 in India → https://ir.novavax.com/2022-03-22-Novavax-and-Serum-Institute-of-India-Announce-First-Emergency-Use-Authorization-of-Novavax-COVID-19-Vaccine-in-Adolescents-12-to-18-in-India | 21:11 |
| de-facto | %title https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.13916 | 21:18 |
| Brainstorm | de-facto, the URL could not be loaded | 21:18 |
| de-facto | "What we can learn from the dynamics of the 1889 ‘Russian flu’ pandemic for the future trajectory of COVID-19" | 21:18 |
| de-facto | %title https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.13889 | 21:19 |
| Brainstorm | de-facto, the URL could not be loaded | 21:19 |
| de-facto | "Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic" | 21:20 |
| -Bridgestorm- 🏠 地震! Earthquake! 6.0 Mw tremor, registered by EMSC, occurred 19 minutes ago (20:29:58 UTC), during a gibbous moon night, Hualien City, Taiwan (23.4, 121.59) ± 1 km, ↓6 km likely felt 270 km away (in 玉里鎮, 花蓮市, 瑞穗鄉, 吉安鄉, 長濱鄉, 光復鄉…) by 346800 people (www.seismicportal.eu) | 21:50 | |
| Brainstorm | Updates for France: +176140 cases, +129 deaths since 23 hours ago — United Kingdom: +95584 cases since 23 hours ago | 22:05 |
| Brainstorm | New from CIDRAP: As Asian hot spots battle Omicron, US eyes supply of 4th vaccine doses: Lisa Schnirring | News Editor | CIDRAP News Mar 22, 2022 Asian countries that were hit later by Omicron surges are in different phases of their outbreaks. → https://www.cidrap.umn.edu/news-perspective/2022/03/asian-hot-spots-battle-omicron-us-eyes-supply-4th-vaccine-doses | 22:19 |
| Brainstorm | New from Ars Technica: Science: 2nd rapid COVID test after a positive swab boosted accuracy from 38% to 92% → https://arstechnica.com/?p=1842910 | 22:58 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): When we say history repeats itself, we don't usually mean in 5 months. And we don't usually mean it so literally.In October, Jen Psaki got COVID-19 and missed going with Biden on a diplomatic trip to Europe.Today the exact same thing happened [... want %more?] → https://twitter.com/michaelzlin/status/1506390594897137665 | 23:07 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Same people, same trip, same virus. Just another day in the wild history of SARSCoV2. pic.twitter.com/2EWjfcUt2d → https://twitter.com/michaelzlin/status/1506391906745413633 | 23:17 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Jen Psaki (and Biden of course) could really use an Omicron booster. → https://twitter.com/michaelzlin/status/1506394928594653189 | 23:27 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A wonderful profile of @edwardcholmes, who calls himself "the Forrest Gump of Covid," and is anything but thatnytimes.com/2022/03/21/hea… by @carlzimmer pic.twitter.com/yLWrcjIaip → https://twitter.com/EricTopol/status/1506398326488403980 | 23:37 |
| LjL | %print https://twitter.com/EricTopol/status/1506353868405297154 | 23:53 |
| Brainstorm | LjL, It says: Eric Topol (@EricTopol): "The BA.2 wave in Western Europe is just starting to turn around ~ 3 weeks in, while there is no sign of increase in cases to date in the US. It's surprising, not easily explained, but gratifying to see —and hope it holds up" | nitter | 23:53 |
| LjL | so american | 23:53 |
| LjL | "we don't know why it sucks for others but not for us, despite us having done everything to make it suck, but hey, good for us, lolthem" | 23:54 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Covid ICU hospitalizations are already at the US pandemic low. With another decline of 700 hospitalizations today, and accounting for a higher proportion of "with" Covid, we are likely at or approaching the lowest number of severe Covid in the US since this all [... want %more?] → https://twitter.com/EricTopol/status/1506403128236658688 | 23:56 |
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