| de-facto | 245$ per citizen | 00:25 |
|---|---|---|
| Brainstorm | New from WebMD: Stealth Omicron Now Dominant COVID Variant in U.S.: The so-called stealth Omicron variant is now the dominant COVID-19 strain in the United States, according to data from the U.S. Centers for Disease Control and Prevention. → https://www.webmd.com/lung/news/20220329/stealth-omicron-now-dominant-covid-variant-in-u-s | 00:34 |
| Brainstorm | Updates for Brazil: +24756 cases, +14 deaths since 22 hours ago | 01:00 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Ouch, bad news!First new Polio case in Israel! And yes, vaccination is critical, but no, not even 5 will protect against infection; antibodies always wanen. timesofisrael.com/first-new-poli… → https://twitter.com/Marc_Veld/status/1508948335469776897 | 01:31 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): New @ScienceTM The mRNA vaccines are not interchangeable.If you got Moderna vaccines, think about getting a Pfizer booster or if you got Pfizers, a Moderna boosterscience.org/doi/10.1126/sc… pic.twitter.com/9GiuvLLH1O → https://twitter.com/EricTopol/status/1508949980727287809 | 01:41 |
| Brainstorm | Updates for Cook Is.: +169 cases, +570 tests since a day ago — Samoa: +129 cases since a day ago | 02:03 |
| LjL | polio in Israel? wtf | 02:06 |
| de-facto | %title https://polioeradication.org/news-post/circulating-vaccine-derived-poliovirus-type-3-confirmed-in-israel/ | 02:14 |
| Brainstorm | de-facto: From polioeradication.org: Circulating vaccine-derived poliovirus type 3 confirmed in Israel – GPEI | 02:14 |
| de-facto | %title https://www.euro.who.int/en/health-topics/communicable-diseases/poliomyelitis/news/news/2022/3/circulating-vaccine-derived-poliovirus-confirmed-in-israel | 02:14 |
| Brainstorm | de-facto: From www.euro.who.int: WHO/Europe | Circulating vaccine-derived poliovirus confirmed in Israel | 02:14 |
| LjL | "In 2009, an adult with a weakened immune system developed VAPP and died of polio-associated complications. VDPV was isolated, and the infection likely occurred where her child received OPV 12 years before." what does this even mean? https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-poliovirus-faq.html | 02:15 |
| LjL | i don't really understand the whole page. what's the distinction between OVP, VDPV...? is VDPV actively spreading and evolving, or does it only tend to come from someone who received the vaccine? | 02:16 |
| LjL | i.e. what does it mean "weakened poliovirus that was initially included in oral polio vaccine (OPV) and that has changed over time and behaves more like the wild or naturally occurring virus" | 02:16 |
| de-facto | iirc the live vaccine for polio was created by serial passage through some animal cells by which few mutations were selected that increased its fitness in those animal cells (for the price of being attenuated in human cells). Normally that would give the immune system enough time to eliminate prior to it causing damage, but... since those are only few (single?) mutations it can mutate back hence become pathogenic again | 02:19 |
| LjL | so each time is a separate mutation event? the mutated virus is not circulating in the wild? | 02:19 |
| LjL | mutated-back, whatever | 02:19 |
| de-facto | problem being: if attenuation only depends on a few key mutations, its not very stable, hence newer methods try to distribute the attenuation property over the whole genome, e.g. by global codon de-optimization or such | 02:20 |
| de-facto | it is mutating (back) and evolving while in circulation i guess, but some key mutations would allow to identify the origin of it (i guess) | 02:21 |
| de-facto | btw there are other polio vaccines, not sure if those problematic ones are still in use (i guess not) | 02:22 |
| de-facto | %title https://www.youtube.com/watch?v=DbhYAbgl8d4 | 02:24 |
| Brainstorm | de-facto: From www.youtube.com: The first polio vaccine was unsafe | Vincent Racaniello and Lex Fridman - YouTube | 02:24 |
| LjL | de-facto, uh, that's a strong-worded title | 02:40 |
| LjL | compared to all the things that say it was worth the risk | 02:40 |
| LjL | de-facto, (yes they are still in use because the inactivated vaccine is expensive and/or requires cold storage) | 02:40 |
| de-facto | obviously it seems to work pretty well yet the risk of relying on few point mutations not to latch back and restore its pathogenic properties is something we should know better with the technical capabilities of todays biotech sector | 02:46 |
| de-facto | seems for the host that receives the attenuated vaccine it is less dangerous (because its immune system got the time advantage to adapt to the attenuated form) yet if it mutates back (to the pathogenic form) it can contaminate the environment of such hosts and thereby pose some kind of threat to other (non-immunized) people in proximity | 02:48 |
| de-facto | thats probably what they mean with vaccine derived polio strains in circulation causing problems | 02:48 |
| Brainstorm | Updates for Australia: +66939 cases, +40 deaths since 23 hours ago — Slovakia: +8277 cases since 23 hours ago | 03:06 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): I posted a column this morning on the BA.2 variant and 2nd booster, the 14th such essay on the pandemic @SubstackInc. It's free to subscribe and that way you won't miss anyerictopol.substack.com/publish/post/5… pic.twitter.com/9ktdoIbAXD → https://twitter.com/EricTopol/status/1508977216280940545 | 03:27 |
| LjL | what does this guy mean, if anything? | 03:39 |
| LjL | %print https://twitter.com/alexmeshkin/status/1508942478723874816 | 03:39 |
| Brainstorm | LjL, It says: Alex Meshkin, GED (@alexmeshkin): "Reminder about case counts. Nobody that had BA.1 in 2022 is counted even if positive today with a lab test. Cooking the books" | nitter | 03:40 |
| de-facto | LjL, maybe he is talking about this? https://twitter.com/alexmeshkin/status/1508978290828095493 | 03:50 |
| LjL | de-facto, yeah some replies also said something similar, a case only being counted as a reinfection if it's within 2 or 3 months of another infection, or such | 03:55 |
| LjL | but then... there has to be a threshold to call it not-a-reinfection anyway | 03:56 |
| Brainstorm | Updates for United Kingdom: +81529 cases since 23 hours ago | 04:02 |
| Brainstorm | New from COVID on Twitter: Josiah 'So Mild' Grindrod (@JT_Grindrod): Disclaimer: I haven't read anything about covid since Feb 2020, I'm basically a baby → https://twitter.com/JT_Grindrod/status/1508986603259064324 | 04:05 |
| LjL | it's weird isn't it, losing track for a couple of months, and it feels almost like one never knew anything about COVID in the first place all over again | 04:06 |
| de-facto | no matter how they are counted, the breeding on the next mutant got *massive* contributions by such large omicron infections numbers | 04:07 |
| de-facto | and we still got just the first gen old Wuhan-Hu-1 s-gene signatures in IM vaccinations | 04:08 |
| de-facto | where are updates of signatures, where are multivalent vaccines, where are intranasal vaccines? | 04:09 |
| de-facto | its almost like all efforts have been given up and its just a question of time until the next, even more infectious and fully evasive mutant spreads worldwide | 04:10 |
| de-facto | well maybe China is still going for ZERO-COVID but all other countries are happily breeding on increasing SARS-COV-2 fitness | 04:10 |
| Brainstorm | New from r/Science: science: Omicron BA.2 Stealth COVID Variant Now Dominant in U.S., CDC Data Shows → https://old.reddit.com/r/science/comments/trvxhx/omicron_ba2_stealth_covid_variant_now_dominant_in/ | 04:53 |
| Brainstorm | Updates for South Korea: +424528 cases, +432 deaths since 23 hours ago — Thailand: +25389 cases, +87 deaths since 23 hours ago | 05:05 |
| Brainstorm | Updates for Germany: +232742 cases since 12 hours ago — Botswana: +41576 cases, +67 deaths since a month ago | 06:01 |
| Brainstorm | Updates for North Rhine-Westphalia, Germany: +367213 cases, +427 deaths since 9 days ago — Lower Saxony, Germany: +239968 cases, +210 deaths since 9 days ago — Bavaria, Germany: +135901 cases, +141 deaths since 2 days ago — Saxony, Germany: +119197 cases, +148 deaths since 9 days ago | 08:00 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Pfizer’s Omicron vaccine upgrade to be tested in Israel: a higher dose of the Pfizer-BioNTech Covid-19 vaccine, the investigational Omicron-based vaccine and a combination of both vaccines given as a fourth dose in [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/ts08s8/pfizers_omicron_vaccine_upgrade_to_be_tested_in/ | 08:44 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: COVID-19 Booster Enhances Protection, Contrary to ‘Immune Fatigue’ Claims: “There’s no evidence whatsoever for immune system burnout or immune system exhaustion from boosters,” → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/ts0elw/covid19_booster_enhances_protection_contrary_to/ | 08:54 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 30, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/ts0l4s/daily_discussion_thread_march_30_2022/ | 09:04 |
| Brainstorm | New from Reddit (test): Covid2019: Gap in COVID-19 vaccine uptake between urban and rural areas in the US continues to widen: CDC - 75% of urbanites have had at least one dose compared to 58% of rural residents. → https://old.reddit.com/r/Covid2019/comments/ts0r7r/gap_in_covid19_vaccine_uptake_between_urban_and/ | 09:13 |
| ZdrytchX | .cases | 09:24 |
| Brainstorm | ZdrytchX: the world has had 489.7 million confirmed cases (6.4% of all people) and 6.2 million deaths (1.3% of cases; 1 in 1232 people) as of an hour ago. 5.9 billion tests were done (0.8 per capita, 8.4% positive). 3.4 billion were vaccinated (44.2%). +744 cases, +1 deaths since 23 hours ago. See https://offloop.net/covid19/?default=the%20world&legacy=no | 09:24 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Antibodies eliciting neutrophil phagocytosis and natural killer cell activation were also increased in mRNA-1273 vaccine recipients as compared to BNT162b2 recipients. → https://twitter.com/Marc_Veld/status/1509079018989051910 | 10:10 |
| Brainstorm | New from StatNews: STAT+: Hospitals, including some flush with cash, scramble to grab last scraps of federal Covid dollars: Hospitals, including some flush with cash, are using their muscle in Washington to catch whatever dollars are left from a nearly depleted Covid relief fund. → https://www.statnews.com/2022/03/30/hospitals-scramble-to-grab-last-scraps-of-federal-covid-dollars/ | 10:39 |
| Brainstorm | New from StatNews: Opinion: There’s no return to normal for millions of children orphaned during Covid: Helping the millions of children who have become orphans during Covid-19 starts with accepting we cannot simply say "How sad," and move on. Instead, we should ask: [... want %more?] → https://www.statnews.com/2022/03/30/no-return-to-normal-for-millions-of-children-become-orphans-by-covid/ | 10:48 |
| Brainstorm | New from StatNews: Opinion: Listen: Tom Sequist on mirrored Covid tragedies — 2,000 miles apart: As chief medical officer of a Boston hospital system, Tom Sequist saw firsthand the damage that Covid-19 did in Chelsea, Mass., and was horrified to watch from afar as the… → https://www.statnews.com/2022/03/30/taos-pueblo-chelsea-mass-covid-disparities/ | 10:58 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: You asked, we’re answering: Your top questions about Covid-19 and vaccines - CNN → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/ts27vq/you_asked_were_answering_your_top_questions_about/ | 11:08 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: A new wave and a new booster? "From my discussions with FDA, it is not likely the Omicron-specific vaccine will be available before late May or June. So you can factor that uncertain added benefit and timeline into [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/ts2fyf/a_new_wave_and_a_new_booster_from_my_discussions/ | 11:27 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): A grim measure of Hong Kong’s devastating COVID wave against backdrop of low vaccination and booster rates among its elderly. NYT reports “HK is scrambling to import more coffins as it struggles to handle the surge in Covid deaths during the [... want %more?] → https://twitter.com/ScottGottliebMD/status/1509104714251710470 | 11:56 |
| Brainstorm | New from BioNTech: BioNTech Announces Fourth Quarter and Full Year 2021 Financial Results and Corporate Update: Fourth quarter and full year revenues of €5.5 billion 1 and €19.0 billion 1 , respectively Full year net income of €10.3 billion [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-announces-fourth-quarter-and-full-year-2021-financial | 12:05 |
| Brainstorm | New from Politico: Coronavirus: German government economic council cuts growth forecast by half → https://www.politico.eu/article/german-government-economic-council-cuts-growth-forecast-by-half/ | 12:25 |
| Brainstorm | New from EMA: What's new: Document: Amended Biologics Working Party (BWP) Ad hoc Influenza Working Group - EU recommendations for the seasonal influenza vaccine composition for the season 2022/2023 → https://www.ema.europa.eu/documents/regulatory-procedural-guideline/amended-biologics-working-party-bwp-ad-hoc-influenza-working-group-eu-recommendations-seasonal/2023_en.pdf | 12:54 |
| Brainstorm | New from BMJ: Covid-19: Americans who are over 50 or immunocompromised are advised to have second booster: Second booster doses against covid-19 for Americans aged over 50 and for certain immunocompromised people aged over 12, using either the Pfizer-BioNTech or the Moderna vaccine, may become available... → http://www.bmj.com/content/376/bmj.o842.short | 13:33 |
| Brainstorm | New from Science-Based Medicine: Update on Long COVID: Recent evidence suggests the burden of long COVID is significant. The post first appeared on Science-Based Medicine . → https://sciencebasedmedicine.org/update-on-long-covid/ | 13:52 |
| Brainstorm | Updates for Bhutan: +1087 cases, +3816 tests since 22 hours ago — Vanuatu: +488 cases since 15 hours ago | 14:04 |
| Brainstorm | New from COVID on Twitter: Jason Mast (@Jasonmmast): Adagio's drug has no activity against BA.2, now the dominant variant in the US. They're gonna apply for FDA authorization anywayendpts.com/adagio-to-pres… → https://twitter.com/Jasonmmast/status/1509137556331544582 | 14:11 |
| Brainstorm | New from Reddit (test): 30/03/22 - ZOE COVID-19 Study Update: 4,378,349 people are currently predicted to have symptomatic COVID-19 in the UK, up by 81,344. Yesterday was 4,297,005 (+2%) and last Wednesday was 3,465,490 (+26%). → https://old.reddit.com/r/CoronavirusUK/comments/ts4tlw/300322_zoe_covid19_study_update/ | 14:30 |
| Brainstorm | Updates for Germany: +238505 cases since 21 hours ago | 15:06 |
| Brainstorm | New from Contagion Live: us: Public Health Watch: NYC Vaccination Exemption for Athletes “Doesn’t Make Much Sense” → https://www.contagionlive.com/view/public-health-watch-nyc-vaccination-exemption-for-athletes-doesn-t-make-much-sense- | 15:09 |
| peetaur | yeah exemption for something that shouldn't be mandatory for anyone makes no sense | 15:18 |
| xx | aren't exemptions irrelevant now? It doesn't seem to be mandatory anywhere anymore | 15:22 |
| Brainstorm | New from COVID on Twitter: Prof. Shane Crotty (@profshanecrotty): Nature did a nice news story on our new COVID vaccines immune memory study comparing four vaccines . 1/2nature.com/articles/d4158… → https://twitter.com/profshanecrotty/status/1509161721793073162 | 15:39 |
| Brainstorm | New from Retraction Watch: Firing, publishing ban, 15 retractions for author who ‘defrauded’ co-authors in pay-to-publish scheme: Cureus has retracted 15 papers, including three on Covid-19, after concluding that the articles were [... want %more?] → https://retractionwatch.com/2022/03/30/firing-publishing-ban-15-retractions-for-author-who-defrauded-co-authors-in-pay-to-publish-scheme/ | 15:49 |
| Brainstorm | New from Reddit (test): CoronavirusUK: End of Scottish face mask rules delayed until Easter → https://old.reddit.com/r/CoronavirusUK/comments/ts6uak/end_of_scottish_face_mask_rules_delayed_until/ | 16:19 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): New cases are close to pandemic peak.But, ironically, imminent plans in England to end free mass testing and change of policies to restrict use and access to testing pic.twitter.com/ICLwlPGV29 → https://twitter.com/EricTopol/status/1509177442748956672 | 16:38 |
| Brainstorm | New from Contagion Live: Black Patients With Cancer Had Worse COVID-19 Outcomes: “Together these 2 diseases create a perfect storm”: Black people with cancer were more likely to have severe or fatal COVID-19 disease. → https://www.contagionlive.com/view/black-patients-with-cancer-had-worse-covid-19-outcomes | 17:08 |
| Jigsy | Oh shit... | 17:23 |
| Jigsy | I just had a terrifying thought. | 17:23 |
| Jigsy | Doesn't Russia have a stockpile of Smallpox? | 17:23 |
| xx | yes | 17:30 |
| xx | quite likely there still are various places in the world that unknowingly store smallpox, in ukraine too | 17:31 |
| xx | anyone's guess whether the virus is still viable | 17:31 |
| pwr22 | Wtf, even though the UK is continuing to plow forward with removing access to LFTs (though they have been very hard to even get for weeks now) and they're even removing the provision of free PCR tests here | 17:32 |
| pwr22 | Cases are coming down now which I feel is due to the restriction on tests and or some smoothing of the data (which I'm pretty sure I've seen the official figures do here twice before during the pandemic) | 17:32 |
| pwr22 | Hospitalisations and deaths are on the climb | 17:32 |
| pwr22 | But it's okay because "half of people in hospital only have covid incidentally and it isn't why they're there" | 17:33 |
| pwr22 | Yes.... that has been the case for a long time | 17:33 |
| pwr22 | So it's not indicative that things are going well 🤦♂️ | 17:33 |
| xx | why do the official sources sound like covid deniers a year ago? | 17:34 |
| pwr22 | 😛 | 17:34 |
| pwr22 | They aren't very innovative and are slow to pick up on things 😉 | 17:34 |
| pwr22 | the UK government that is | 17:34 |
| pwr22 | UK gov sounds like Trump as well. Cases are too high so test less | 17:37 |
| Brainstorm | New from BMJ: Covid-19: NHS staff will still have access to free tests: NHS and care staff, as well as some vulnerable patients, will continue to have access to free testing for covid-19 in a move that has been welcomed as a victory for common sense.In February it was... → http://www.bmj.com/content/376/bmj.o851.short | 17:58 |
| Brainstorm | Updates for Netherlands: +27766 cases, +37 deaths since 13 hours ago | 18:02 |
| Brainstorm | New from Reddit (test): China_Flu: Fully vaccinated ship docks in San Francisco with multiple COVID cases aboard → https://old.reddit.com/r/China_Flu/comments/ts9r5n/fully_vaccinated_ship_docks_in_san_francisco_with/ | 18:17 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): For all those who respond with Moderna's NHP study with "no clear" advantage of a single Omicron booster, understand it takes time to change an immune response, beware of hasty conclusions and Type 2 statistical errors, and see this parallel [... want %more?] → https://twitter.com/michaelzlin/status/1509204686343090178 | 18:27 |
| de-facto | yeah wait for the next more severe mutant, then officials will paddle back nervously when daily new hospitalizations are expoentials | 19:01 |
| de-facto | the errors are mostly made in times when people assume the situation is less severe, its always like that | 19:02 |
| peetaur | their solution is a non-solution, but do you have a better one? ruining the economy didn't work ....maybe they plan to only ruin it each winter instead; is that so bad? | 19:05 |
| oerheks | one could have common flu .. | 19:06 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Exemplar of #AI for goodFacilitating humanitarian aid in the pandemicnature.com/articles/s4158…@jblumenstock @deankarlan @chrisudry and colleagues@Nature pic.twitter.com/GmkN67FZ0R → https://twitter.com/EricTopol/status/1509214061245853699 | 19:06 |
| Brainstorm | Updates for Tonga: +4 deaths since 5 hours ago — Vanuatu: +1 deaths since 21 hours ago | 19:11 |
| de-facto | imho the solution is to close transmission paths without lockdowns and make biweekly testing mandatory | 19:12 |
| de-facto | this will may become the most transmissible virus we have ever seen (yet that remains to be seen) | 19:13 |
| de-facto | i mean what should we expect from opening transmission pathways as soon as daily new infections stop to rise? | 19:18 |
| de-facto | instead we should have transmission pathways closed to prevent continuation of breeding more fit mutants | 19:19 |
| Brainstorm | New from COVID on Twitter: Dr Emma Hodcroft (@firefoxx66): "To make good decisions you need two things: good data & good people"@_MiguelHernan at @ISPMBern #ISPMwinterSchool talking about observational data & #COVID19 trials."If you have these things, you can make decisions based on your own country, not someone [... want %more?] → https://twitter.com/firefoxx66/status/1509222089332510731 | 19:36 |
| LjL | %print https://twitter.com/SolNataMD/status/1485592953003327491 | 19:39 |
| Brainstorm | LjL, It says: Dr. Natalia 🌻 💙💛 (@SolNataMD): "Hospital trick: patients admitted with covid in 10-12 days become post-covid & no longer counted as hospitalized covid patients. ICU is full of post-covid patients that are here for 30, 40, 50 & more days. Not counted in the official stats." | Hungary-based nitter instance by Hackerspace Szeged | 19:39 |
| LjL | one of i think many possible reasons why even hospitalization data may not necessarily be relied upon as "objective" | 19:39 |
| LjL | hi ublx | 19:39 |
| ublx | morning | 19:39 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): When South Korea is still struggling to gain control over Omicron BA1. and BA.2 (cases and deaths ), you know how formidable these variants are@OurWorldInData covariants.org pic.twitter.com/lCUXjx1J9K → https://twitter.com/EricTopol/status/1509223901217259524 | 19:46 |
| Brainstorm | New from COVID19 Vaccine Tracker: (translated) valerie: AnGes: AG0301-COVID19 → https://covid19.trackvaccines.org/vaccines/3/ | 19:56 |
| Brainstorm | Updates for Japan: +51924 cases, +96 deaths since 12 hours ago — United Kingdom: +86860 cases, +213 deaths, +820513 tests since 21 hours ago — Italy: +71411 cases, +170 deaths, +524899 tests since 22 hours ago — Canada: +3 deaths since 21 hours ago | 20:01 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A gaping trillion dollar hole in investing for vaccines for pandemic preparedness @ScienceTM science.org/doi/10.1126/sc… pic.twitter.com/8FbDktxS9F → https://twitter.com/EricTopol/status/1509229334438969345 | 20:05 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: AIM Vaccine: LVRNA009 → https://covid19.trackvaccines.org/vaccines/189/ | 20:15 |
| LjL | %print https://twitter.com/fitterhappierAJ/status/1508936932495179780 | 20:24 |
| Brainstorm | LjL, It says: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "Hey look, what is this? 1st infection- 19% hospitalized 2nd infection- 17% hospitalized 3rd infection- 25.9% hospitalized" | 42l - nitter | 20:24 |
| LjL | https://www.medrxiv.org/content/10.1101/2021.07.22.21260972v2.full.pdf | 20:24 |
| LjL | However, a higher Intensive Care Unit (ICU) admission rate was observed in reinfection compared to first infection (10 vs 3). | 20:24 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): First patent-free Covid19 vaccine Corbevax approved for use in Botswana! twitter.com/PeterHotez/sta… → https://twitter.com/TWenseleers/status/1509233639489519618 | 20:25 |
| LjL | https://www.medrxiv.org/content/10.1101/2022.03.20.22272571v1.full.pdf | 20:25 |
| LjL | The absolute number of re-infections increased from less than 500 per month through November 2021, to over | 20:26 |
| LjL | 4,000 per month in January 2022. | 20:26 |
| LjL | just throwing out there, am not really in the mindset to read the studies in detail (yeah okay i never am) | 20:26 |
| xx | re-infections have probably been happening for years, they were just keeping quiet about it to reduce panic | 20:31 |
| de-facto | antigenic shift | 20:31 |
| Brainstorm | New from ##covid-19 Zotero group: https://twitter.com/fitterhappieraj/status/1508936932495179780: Type Web Page URL Accessed 2022-03-30 18:32:29 Language en Website Title Twitter Short Title https → https://www.zotero.org/groups/covid_links/items/WKPGRNFN | 20:35 |
| LjL | xx, the point here is re-infections appear to be *more severe*, not that they happen | 20:38 |
| xx | well yes, of course reinfections are more severe, your immune system is fucked from the first time you got it | 20:39 |
| LjL | of course the amount in which they happen makes the increased severity differently concerning, too | 20:39 |
| xx | fucked = in various ways out of normal state | 20:39 |
| xx | it's a dumb thought that many people have that "whatever doesn't kill you makes you stronger" | 20:40 |
| xx | real world doesn't work that way | 20:40 |
| xx | every disease makes you weaker and puts a permanent burden on your immune system | 20:40 |
| oerheks | yes, it is not gone, like the spanish flu after 2 years. | 20:41 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: Airlangga University: UNAIR Inactivated COVID-19 Vaccine → https://covid19.trackvaccines.org/vaccines/181/ | 20:45 |
| de-facto | instead we see infection rates that increase by roughly an *order of magnitude* each year | 20:49 |
| de-facto | https://www.worldometers.info/coronavirus/country/germany/ | 20:52 |
| Arsanerit | xx: Does anybody actually think that? | 20:53 |
| LjL | sure | 20:54 |
| Arsanerit | but I don't see how it's "of course" that second infections are worse, I would expect that the immune system has better defences the second time compared to the first | 20:54 |
| de-facto | Daily COVID infections in Germany 2020: ~6k, 2021: ~25k, 2022: ~225k | 20:54 |
| de-facto | as many deaths as in 2020, but nobody cares about fatalities anymore it seems | 20:55 |
| de-facto | over 200 patients loose the fight for their life each single day in Germany right now and suffocate from COVID | 20:56 |
| de-facto | back in 2020 it was a reason for lockdowns, now our health minister canceled the federal law for restrictions and blames the communities for not implementing restrictions | 20:57 |
| de-facto | when politicians start to point with fingers at each others its clear they are not interested in solving any problems | 20:58 |
| Arsanerit | It seems hospitals are doing okay | 20:59 |
| Arsanerit | at least it doesn't seem there's overload in intensive care | 20:59 |
| Arsanerit | and contrary to 2021 or 2020 most adults are vaccinated now | 21:00 |
| de-facto | https://www.intensivregister.de/#/aktuelle-lage/zeitreihen | 21:00 |
| de-facto | at constantly high level | 21:00 |
| de-facto | indicating the infection pressure produces constantly high rates of people with serious enough health damage that they need help from hospitals | 21:01 |
| de-facto | a fraction of those will not survive, another quite large fraction will have their health ruined permanently | 21:01 |
| de-facto | imho that is not OK at all, its completely unacceptable | 21:02 |
| Arsanerit | Looks like the delta wave had a serious peak but the omicron wake doesn't. | 21:02 |
| Arsanerit | despite the high number of inections | 21:02 |
| de-facto | its constantly producing hospitalizations at about half the rate than the Delta peak | 21:03 |
| Arsanerit | apparently | 21:03 |
| de-facto | thats not ok | 21:03 |
| Arsanerit | but it seems that that rate is not causing overloading of ICUs? | 21:03 |
| de-facto | it has to be forced down | 21:03 |
| Brainstorm | Updates for France: +36 cases since 22 hours ago — Norway: +5 cases, +179 deaths since 17 hours ago | 21:03 |
| de-facto | its causing a constant accumulation of health damage in the population | 21:04 |
| Arsanerit | (+36 cases?) | 21:04 |
| de-facto | and btw its breeding a new mutant we might see quite soon | 21:05 |
| Arsanerit | ye, it's bad luck to get long covid | 21:05 |
| de-facto | tolerating high infection pressure is all wrong | 21:05 |
| * Arsanerit will continue to wear FFP2 in public places | 21:05 | |
| xx | Arsanerit: looks like *everyone* has long-covid | 21:05 |
| Arsanerit | xx: how so? | 21:05 |
| xx | permanent brain damage in everyone infected | 21:05 |
| xx | but it might not be noticeable in many | 21:06 |
| xx | because most people don't really do stuff that requires brain | 21:06 |
| Arsanerit | most adults inflect themselves permanent brain damage every day (alcohol), without qualification and quantification that's not a very meaningful statement | 21:06 |
| de-facto | it will have impact on economies that rely on the mental capabilities of their working age population | 21:07 |
| de-facto | e.g. people working as engineers, software developers, financial industry, etc pp | 21:07 |
| Arsanerit | The FDP is in the government, so we won't have federal lockdowns anymore. | 21:07 |
| de-facto | well lockdowns are indicators for failed strategies | 21:08 |
| de-facto | we instead need effective targeting of transmission pathways combines with mandatory testing | 21:08 |
| de-facto | and trashing that stupid 3G concept | 21:09 |
| Arsanerit | how does that work? | 21:09 |
| de-facto | work on a ranking list for which transmission pathways are currently contributing the most to daily new infections and think about most effective ways (with least impact on economy) to close them down | 21:11 |
| de-facto | then instead of requiring vaccination for participation, make PCR biweekly testing for everyone mandatory | 21:11 |
| de-facto | make the infrastructure for that as effective as possible, reducing the required efforts for doing the tests as much as possible, minimize consumables for the tests etc | 21:12 |
| Arsanerit | Would that work? Is that implemented anywhere? | 21:14 |
| LjL | reuse swabs | 21:17 |
| de-facto | why not have people gargle with saline solution and have them spit into a tube that gets collected at their daily routine locations? | 21:18 |
| xx | how is china doing? | 21:19 |
| de-facto | they locked down Shanghai | 21:19 |
| xx | I hear they lock down entire cities, so maybe they are doing something right | 21:19 |
| Arsanerit | or not | 21:19 |
| Arsanerit | I'm not sure if locking down 26 million people two years after the pandemic has started and apparently without good vaccines or a good vaccination rate is a sign of success. | 21:20 |
| de-facto | i think aiming for ZERO-COVID is the correct approach, if their implementation of it is the best way remains to be seen | 21:20 |
| de-facto | well they prevented the majority of their population from health damage so far | 21:20 |
| de-facto | also they got economic growth all the time | 21:21 |
| de-facto | so from those two metrics they are not doing too bad at all | 21:21 |
| xx | I hear in ukraine some cities have curfews and lockdowns where people are prevented from leaving | 21:22 |
| Arsanerit | They're also a dictatorship where spreading truthful bad news may make you disappear. | 21:22 |
| Brainstorm | New from CIDRAP: (translated) NewsScan for Mar 30, 2022: Long-term COVID lung damage COVID-19 taste loss → https://www.cidrap.umn.edu/news-perspective/2022/03/news-scan-mar-30-2022 | 21:23 |
| de-facto | %title https://www.imf.org/external/datamapper/NGDP_RPCH@WEO/OEMDC/ADVEC/WEOWORLD | 21:24 |
| Brainstorm | de-facto: From www.imf.org: error parsing title ('NoneType' object has no attribute 'string') | 21:24 |
| de-facto | "Real GDP growth Annual percent chang" worldmap | 21:24 |
| de-facto | xx not too funny | 21:25 |
| xx | de-facto: it means any new variant that might emerge in such a city is likely to die out in such a closed off community instead of spreading elsewhere | 21:30 |
| xx | we'd be much better off if people wouldn't travel | 21:30 |
| `St0ner | just got 3rd dose, which was a halfdose of moderna | 21:31 |
| de-facto | %title http://medrxiv.org/cgi/content/short/2022.03.26.22272979v1 | 21:40 |
| Brainstorm | de-facto: From medrxiv.org: Impact of the Russian invasion of Ukraine on the COVID-19 pandemic dynamics | medRxiv | 21:40 |
| Arsanerit | refugees don't have much of a choice | 21:41 |
| de-facto | `St0ner, nice that broadens your antibody spectrum considerably (making it possible to bind to a larger variety of variants) | 21:41 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Nice summary of the situation here: theconversation.com/covid-19-vacci… → https://twitter.com/michaelzlin/status/1509252163813269505 | 21:43 |
| `St0ner | my first was pfizer, second moderna, then i think i caught omicron this january (very mild), then i think i was near people who have BA.2 within past 2 weeks and sneezed a few times (extremely mild), then boosted today with half dose moderna | 21:43 |
| Arsanerit | I hope there will be nasal variant vaccines soon. | 21:44 |
| `St0ner | my friend who is triple-boosted caught something within past 7 days, probably BA.2, and its hitting him hard | 21:45 |
| de-facto | well `St0ner seems your immune system has seen quite some variants then | 21:46 |
| de-facto | tripple boosted? | 21:47 |
| LjL | every once in a while the subject of N-protein assays to know if you had COVID while vaccinated comes up | 21:47 |
| LjL | but have we ever actually stumbled upon a commercially available such test? | 21:47 |
| `St0ner | triple-dosed. same formulation for the "booster" here | 21:47 |
| de-facto | 3 doses of mRNA all in all? | 21:47 |
| de-facto | LjL, isnt that possible to buy as a lab test from a MD taking blood? | 21:48 |
| `St0ner | yup | 21:48 |
| de-facto | ok here in Germany we call that "boosted" e.g. primary shot (1st), completing shot (2nd shot) and then boosting shot (3rd shot) | 21:49 |
| Arsanerit | + second booster | 21:50 |
| Arsanerit | what's the prospect of adapted vaccines? | 21:50 |
| `St0ner | potato tomato :) technically that's what they say here too. all 3 shots in my opinion boost your immunity, and can all be called boosters, especially since all 3 shots are the same composition/formula | 21:50 |
| LjL | Arsanerit, so far Omicron-specific shots have seemed not to be anything special compared to the regular shot | 21:51 |
| LjL | but i think it all depends on future variants | 21:51 |
| de-facto | i want to have at least an omicron specific shot or a multivalent shot to broaden my antibody spectrum, i dont see a sense in a fourth Wuhan-Hu-1 (it seems to broaden the spectrum 3 times but not really for 4th time iirc) | 21:53 |
| LjL | xx, what is the deal you say with memory T cell "burden" being always a negative thing as the bottom line, or similar? | 21:53 |
| Arsanerit | ok | 21:54 |
| `St0ner | https://www.japantimes.co.jp/news/2022/02/07/national/pfizer-moderna-booster-shots/ and the research quoted within this article says moderna as a booster, even at half dose, lasts slightly longer than pfizer | 21:59 |
| `St0ner | "in general" and "no marked difference in effectiveness against the omicron variant" | 22:00 |
| Jigsy | %cases UK | 22:01 |
| Brainstorm | Jigsy: United Kingdom has had 21.2 million confirmed cases (32.0% of all people) and 165782 deaths (0.8% of cases; 1 in 401 people) as of 58 minutes ago. 504.2 million tests were done (7.6 per capita, 4.2% positive). 51.8 million were vaccinated (78.0%). +86860 cases, +213 deaths, +820513 tests since 21 hours ago. See https://coronavirus.data.gov.uk/ | 22:01 |
| LjL | `St0ner, although i also seem to remember something like that (but mostly i remember studies about full-dose Moderna and it was hard to find ones about half-dose, but eventually, there was a couple), i am somewhat skeptical of it being stressed in an article that clearly wants to make more people take Moderna because admittedly too few are | 22:02 |
| de-facto | modeRNA usually is 100µg mRNA-1273 for primer and completion shots, 50 µg mRNA-1273 for boosting, BioNTech usually is 30µg BNT162b2 for first two and again 30µg BNT162b2 for boosting, yet since the mRNA coding is different they might differ in the frequency of protein synthesis (per mRNA strain) and also in the number of protein molecules until a mRNA molecule is destroyed | 22:03 |
| LjL | yeah the article also makes this comparison but i don't think it's reasonable to assume the simple weight comparison holds up to any scrutiny | 22:05 |
| Brainstorm | New from NPR Science: CDC drops its COVID-19 risk advisory for cruise ship travel: While the agency has lifted its travel health notice two years after putting it in place, officials say it's up to travelers to determine their own health risks before going aboard a ship. → https://www.npr.org/sections/coronavirus-live-updates/2022/03/30/1089748769/cdc-cruise-travel-covid | 22:50 |
| Brainstorm | Updates for Germany: +273983 cases since 23 hours ago — Canada: +5008 cases, +14 deaths since 23 hours ago | 23:02 |
| de-facto | yay almost 300k daily new infections | 23:07 |
| de-facto | in reality probably manyfold of the officially registered numbers | 23:07 |
| de-facto | our health minister is a failure | 23:08 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): @NEJMFor children ages 5-11, during the Omicron wave, vaccination reduced the risk of hospitalizations by 68% (95% CI 42,82)nejm.org/doi/full/10.10… → https://twitter.com/EricTopol/status/1509274516542820352 | 23:09 |
| LjL | de-facto: you liked him before he became minister, didn't you? | 23:10 |
| LjL | Most countries are doing similar things so I'm not sure it's really his decisions so much | 23:10 |
| de-facto | he really does not have any excuses for this as he holds a degree in Epidemiology | 23:11 |
| de-facto | i am severely disappointed by his performance so far | 23:12 |
| de-facto | maybe my expectations were too high | 23:12 |
| de-facto | he has to get judged by the results he achieved, no matter how he talks, in the end its the results that make the difference | 23:13 |
| de-facto | Germany got one of the highest infection rates in EU right now, and its his fault | 23:13 |
| de-facto | he would have had ONE job: Rt < 1 | 23:14 |
| darsie | Perhaps that's a difficult job. | 23:14 |
| de-facto | but he failed, he even took away federal law for closing down transmission pathways and now makes local managements carry that burden, of course they wont decide to do that because they are too close bundled with the local industry | 23:15 |
| de-facto | yes its a difficult job, but he knew that in advance | 23:17 |
| de-facto | if he cant do it, he should give his place to someone else that does a proper job | 23:18 |
| de-facto | there are no excuses for hundreds of thousands of daily new infections, none at all. | 23:18 |
| de-facto | this is a complete disaster. | 23:18 |
| aruns | de-facto: Oh you're German? | 23:19 |
| Brainstorm | New from r/COVID19: COVID19: Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis → https://old.reddit.com/r/COVID19/comments/tsjgcm/conservation_and_enhanced_binding_of_sarscov2/ | 23:19 |
| de-facto | aruns, yes | 23:19 |
| de-facto | aruns, are you form UK? | 23:20 |
| aruns | Yes | 23:20 |
| aruns | Thought you were talking about Sajid Javad | 23:21 |
| aruns | Since a UK article came up | 23:21 |
| aruns | *Javid | 23:21 |
| de-facto | oh he also is epidemiologist? | 23:21 |
| aruns | No. | 23:21 |
| aruns | Attended trade school. | 23:21 |
| aruns | Oh he actually attended the University of Exter. | 23:22 |
| de-facto | ah ok, i was talking about the (new) Germany minister for health, Karl Lauterbach | 23:22 |
| aruns | *Exeter | 23:22 |
| aruns | I did not realise that. | 23:22 |
| de-facto | he was (is) very good in criticizing, but now he is in a position that requires to deliver | 23:23 |
| de-facto | https://ourworldindata.org/explorers/coronavirus-data-explorer?tab=map&zoomToSelection=true&time=latest&facet=none&pickerSort=asc&pickerMetric=location&hideControls=true&Interval=7-day+rolling+average&Relative+to+Population=true&Color+by+test+positivity=false&country=IND~USA~GBR~CAN~DEU~FRA&Metric=Confirmed+cases | 23:25 |
| de-facto | looks like Germany is performing the f-ing worst right now | 23:25 |
| aruns | de-facto: Tbh, maybe it's the disconnect between academia and real world experience. | 23:26 |
| de-facto | and numbers climbing, while our health minister has nothing better to do that taking back restrictions and the base for requiring people to wear masks etc | 23:26 |
| aruns | Hands on versus thereotical. | 23:26 |
| aruns | *theoretical | 23:26 |
| de-facto | yes i think so too | 23:26 |
| de-facto | now he has to get people to do things, thats a big difference to saying in theory what woudl be best | 23:27 |
| Brainstorm | New from r/COVID19: COVID19: TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection → https://old.reddit.com/r/COVID19/comments/tsjne4/tlr2_and_tlr7_mediate_distinct_immunopathological/ | 23:29 |
| de-facto | maybe he should spend less time in TV and interviews and invest more time in his actual job to organize the best way to ensure Rt < 1 | 23:31 |
| de-facto | i think he did not fully realize yet that its now HIM being responsible for that, as he still is in this old attitude of criticizing others publicly instead of delivering solutions | 23:32 |
| de-facto | he should accumulate responsibility on his chair and then make decisions that help with reducing infections, instead he outsources national responsibility towards the federal states and then blames them for HIS failure to implement Rt < 1 | 23:35 |
| de-facto | that way he always can take the old convenient position of blaming the others :( | 23:35 |
| aruns | that way he always can take the old convenient position of blaming the others :( | 23:36 |
| aruns | Maybe too used to being in opposition? | 23:36 |
| aruns | :D | 23:36 |
| de-facto | yes thats how he was introduced to the pandemic | 23:36 |
| de-facto | and of course local management such as federal state ministers or mayors would compete in NOT requiring anything that potentially could be seen as harming economy or such | 23:36 |
| de-facto | and by refusing to take national responsibility for such decisions, he took away the ability for local management to blame such inconvenient decisions on the hierarchy above | 23:37 |
| de-facto | result being: noone implements restrictions anymore and everyone blames the others in the hierarchy | 23:37 |
| de-facto | at least he could have tried to find a more successful approach in dealing with the infection pressure | 23:39 |
| de-facto | he got all the correct ideas (from what he is talking) but he actually has to implement them in reality | 23:42 |
| Brainstorm | New from r/COVID19: COVID19: Effect of Early Treatment with Ivermectin among Patients with Covid-19 → https://old.reddit.com/r/COVID19/comments/tsk43m/effect_of_early_treatment_with_ivermectin_among/ | 23:48 |
| Juerd | tl;dr: no effect | 23:50 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): In the United States, for children age 5 to 11, with such strong protection vs risk of Omicron hospitalization, less than 28% of 29 million in this age group are vaccinated. → https://twitter.com/EricTopol/status/1509286825944227841 | 23:58 |
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