| Brainstorm | Updates for United Kingdom: +603 cases since 3 hours ago | 00:04 |
|---|---|---|
| Brainstorm | Updates for Germany: +62697 cases, +150 deaths since 17 hours ago | 01:00 |
| Brainstorm | Updates for Cook Is.: +230 cases since 12 hours ago | 02:03 |
| Brainstorm | Updates for Samoa: +173 cases since 12 hours ago — Canada: +868 cases, +83857 tests since 9 hours ago | 02:59 |
| Brainstorm | Updates for New Zealand: +14183 cases, +23 deaths since 23 hours ago | 06:01 |
| Brainstorm | Updates for Kentucky, United States: +1317037 cases, +15068 deaths since 2 days ago — Unknown, China: +26917 cases since 2 days ago — South Australia, Australia: +11218 cases, +4 deaths since a day ago — Tasmania, Australia: +2432 cases since a day ago | 08:06 |
| Brainstorm | Updates for France: +11 deaths since 12 hours ago | 11:01 |
| Brainstorm | Updates for Germany: +167264 cases since 18 hours ago | 12:10 |
| Brainstorm | Updates for Canada: +1404 cases, +2 deaths since 20 hours ago | 17:05 |
| Brainstorm | Updates for Germany: +139353 cases, +256 deaths since 17 hours ago | 18:07 |
| Brainstorm | Updates for Singapore: +6341 cases since 13 hours ago | 19:10 |
| * LjL-Matrix is mad abour | 19:25 | |
| LjL-Matrix | About* | 19:25 |
| LjL-Matrix | Uh Element isn't sending, weird, it locked up and failed to send and got the phone all warm on the other phone too | 19:26 |
| LjL-Matrix | pwr22 @pwr22:shortestpath.dev: has Element been sending files alright and otherwise behaving okay for you past couple of days? | 19:27 |
| * LjL-Matrix uploaded a video: (5187KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/TCVQNORWafmPMwbkGxsbLEqX/VID_20220405_192430.mp4 > | 19:27 | |
| pwr22 | LjL-Matrix: Yeah, as far as I know | 19:30 |
| LjL | de-facto, do you remember anything about aspirin doses that are supposed to be helpful and ones that are suspected to be harmful? | 19:48 |
| de-facto | hmm not sure, it depends on the condition i guess? | 20:06 |
| LjL | de-facto, for COVID :P | 20:06 |
| Brainstorm | Updates for Japan: +40316 cases, +64 deaths since 13 hours ago — Israel: +10540 cases since 21 hours ago — Italy: +88914 cases, +194 deaths, +588576 tests since a day ago — United Kingdom: +50624 cases, +368 deaths, +2162835 tests since 20 hours ago | 20:07 |
| LjL | oh my :( | 20:07 |
| LjL | %cases japan | 20:07 |
| Brainstorm | LjL: Japan has had 6.8 million confirmed cases (5.4% of all people) and 28396 deaths (0.4% of cases; 1 in 4435 people) as of 40 seconds ago. 43.9 million tests were done (0.3 per capita, 15.4% positive). 101.2 million were vaccinated (80.3%). +40316 cases, +64 deaths since 13 hours ago. See https://covid19japan.com/ | 20:07 |
| de-facto | LjL, I'd take things against C☼V:D | 20:09 |
| de-facto | not sure, if anti-coagulation is the main purpose it depends on age and body mass | 20:10 |
| de-facto | iirc the "baby Aspirin" of ~100mg is not really having such a big effect for normal weight adults | 20:10 |
| LjL | it's not me so i shouldn't recommend things that are too weird. but... yeah the thing is he actually found a study saying that *higher*-dose aspirin may be harmful and instead ~100mg may be useful for COVID | 20:11 |
| LjL | so now i'm confused whether he should take the 500mg pill or much less | 20:11 |
| de-facto | was it more like 300-500mg? but then it also got other side-effects | 20:11 |
| LjL | well not a study, he was quoting from wikipedia | 20:11 |
| LjL | "The studies examining aspirin in COVID-19 have not used high-dose aspirin which has potent antipyretic and anti-inflammatory effects. High-dose aspirin can be potentially detrimental in COVID-19 patients. First, aspirin in doses of 160 mg per day and above inhibit COX-2 in endothelial cells and inhibit synthesis of prostacyclin [27], further aggravating endothelial dysfunction, a hallmark of COVID-19. Second, aspirin dose of 81 mg per day but not higher is most | 20:11 |
| LjL | effective in stimulating synthesis of resolvins [20], the potent anti-inflammatory lipids that could prevent or mitigate the long COVID syndrome. Third, gastrointestinal toxicity by high-dose aspirin could promote risk of bleeding especially in patients receiving anticoagulants." | 20:11 |
| LjL | "potentially detrimental" doesn't sound like something i want to be recommending | 20:12 |
| LjL | actually it's from here https://www.tandfonline.com/doi/full/10.1080/13543784.2021.1950687 | 20:12 |
| de-facto | yes bleeding in stomach or brain could be dangerous actually | 20:13 |
| de-facto | e.g. stomach bleeding almost can not be stopped and if bleeding in the brain would occur it obviously would be very bad, thats what my MD warned be about when i revealed to her that i was on 100mg per day (without having COVID) | 20:14 |
| de-facto | i did not continue Aspirin, but rather take a pill of Ginkgo now everyday, because i feel good with that | 20:14 |
| de-facto | also it never should be taken on empty stomach or such | 20:16 |
| LjL | here's a metareview https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556685/ but many of these things don't mention doses, being reviews | 20:16 |
| LjL | well baby aspirin can be useful to take as prophylactic but 1) for people with known conditions, not just for you if you're fine and 2) i think the trend lately is for using it less | 20:17 |
| de-facto | i remember a meta study that concluded i would have had to take 300 and something mg for it to be effective | 20:18 |
| LjL | but, another thing is taking it for a short period when you know you have covid | 20:18 |
| de-facto | btw that one is published | 20:19 |
| de-facto | the one you linked | 20:19 |
| de-facto | %title https://cegh.net/article/S2213-3984(21)00191-3/fulltext | 20:19 |
| Brainstorm | de-facto: From cegh.net: The effects of aspirin on the outcome of COVID-19: A systematic review and meta-analysis - Clinical Epidemiology and Global Health | 20:19 |
| de-facto | but LjL i guess it also depends on severity, e.g. if SARS-CoV-2 would be able to spread to multiple organs with a severe progression or mainly would get eliminated on surface of mucus or such | 20:21 |
| de-facto | hence my initial remark about the condition, e.g. spectrum of symptomatic trajectory | 20:22 |
| de-facto | yet that paper you linked also mentions other than anticoagulation for platelets | 20:23 |
| de-facto | so maybe it also is somewhat helpful in mild cases? | 20:24 |
| LjL | uhm this meta-review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556685/ is positive for dosages around 80-100mg, but it's all retrospective studies, with the patients taking aspirin having a lot more circulation issues in the first place... they adjust for that, but i still don't like the method | 20:33 |
| LjL | surely there is a proper double blinded study | 20:34 |
| de-facto | yeah if the choice to take Aspirin was already made before getting contaminated with SARS-CoV-2 and developing COVID its a special (biased) selection of people | 20:35 |
| de-facto | best surely would be to have something like a double blinded study comparing placebo with verum for different severity and age groups | 20:36 |
| mrdata | some people take 81 mg aspirin daily | 21:24 |
| mrdata | surely some of these got covid | 21:25 |
| mrdata | you can compae this population to the general population | 21:26 |
| mrdata | *compare | 21:26 |
| de-facto | what i meant was that those people that already got a reason to take Asprin prior to getting COVID had a reason to take it that distinguishes them from the majority that does not take Aspirin (without COVID) | 21:48 |
| de-facto | hence its biased selection that way | 21:48 |
| Brainstorm | Updates for France: +203101 cases, +131 deaths since 23 hours ago | 21:59 |
| Arsanerit | How did Swedens score drop from 5.2 to 0.5 in a week? https://www.ecdc.europa.eu/en/covid-19/country-overviews | 22:03 |
| de-facto | oh finally they begin to realize that long COVID could be a national problem | 22:31 |
| de-facto | https://www.reuters.com/world/us/white-house-launches-national-plan-address-long-covid-2022-04-05/ | 22:31 |
| de-facto | %title | 22:31 |
| Brainstorm | de-facto: From www.reuters.com: Biden launches U.S. plan to help Americans struggling with long COVID | Reuters | 22:31 |
| LjL | mrdata, that's pretty much what those studies in the meta-reviews did. however the problem is that the population that already takes aspirin daily is different from the ones who don't (tend to be older, have cardio-vascular issues, etc) | 23:02 |
| de-facto | in addition ot that their bodies may have adapted somehow to longterm Aspirin exposure, not sure that that means though, maybe upregulated/downregulated pathways to counterbalance those affected by the longterm Aspirin exposure? | 23:08 |
| de-facto | LjL, did you disable Brainstorm feeds? | 23:10 |
| LjL | not on purpose, but i may have broken it | 23:11 |
| LjL | yeah i broke it while trying to disable the gray coloring in ##EU | 23:13 |
| Brainstorm | New from WebMD: White House Announces Long-COVID Action Plan: The National Research Action Plan on Long COVID will gather experts from various agencies to expand existing long-COVID clinics and broaden ongoing research on symptoms of the virus that persist long after infection. → https://www.webmd.com/lung/news/20220405/white-house-announces-plan-for-long-covid | 23:31 |
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