libera/##covid-19/ Wednesday, 2022-05-18

ferret	anyone know how long this cough will last lol	00:18
Asako	weeks ?	00:19
ferret	christ	00:19
ferret	even lost my voice	00:19
Asako	can be much worse, from experience	00:21
ferret	Asako: the cough part?	00:21
Asako	i'd had no cough, I had extreme neck pain	00:22
ferret	ouch	00:22
Brainstorm	New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Immune recall improves antibody durability and breadth to SARS-CoV-2 variantsscience.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/1526688100033904640	00:24
Brainstorm	New from The Lancet (Online): [Series] Global health diplomacy—reconstructing power and governance: Over the past two decades, global health diplomacy, foreign policy for health, and global health policy have changed substantially. Diplomacy is a constitutive part of the system of global [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00583-9/fulltext	00:33
LjL	ferret, there are mucus thinners like n-acetylcysteine, maybe you can ask your pharmacy if that would make sense for you	00:46
LjL	cough can linger on for a while :(	00:46
LjL	note n-acetylcysteine is liver metabolized	00:46
ferret	LjL: oh nice! ill take a look around	00:47
ferret	LjL: think my immune system sucks lol. Everyone else i know never lost there voice	00:49
ferret	lol	00:49
de-facto	also there are special compositions of tea to ease coughing	00:55
LjL-Matrix	ferret: I'm too half asleep to check now, but I think change in taste and/or hoarse voice could also be due to molnupiravir. But they're also things that COVID does. Sure, it's better if it doesn't :p	00:55
de-facto	here they sell such tea containing lime blossoms, anise, thyme, licorice root, rosehip peels	00:57
de-facto	also green tea is always good :)	00:58
ferret	yea i kind of messed up with the molnupiravir. Took 4 200 MG pills waited 12 hours later and took 2 200 MG pills and stopped the treatment	00:59
ferret	lol	00:59
ferret	de-facto: yum green tea :D	00:59
de-facto	lol yeah thats exactly how not to do it, if you stop Molnupiravir too early it will leave a lot of heavily mutated virions alive	01:00
de-facto	so if you pass those on to other people it may be the start of a new VoC	01:01
de-facto	imho exactly why such drugs should not be on the market	01:01
ferret	i did try to vomit	01:01
ferret	the molnupiravir	01:01
ferret	who knows how much though	01:02
de-facto	just stay away from other people until you recovered	01:02
Brainstorm	Updates for Brazil: +26386 cases since 22 hours ago — Uruguay: +5538 cases, +2 deaths since 7 days ago	01:03
ferret	de-facto: im already responsible for infecting one person	01:03
ferret	totaly by accident	01:03
ferret	the person on the other side of the building managed to get infected by my coughing and the air system	01:04
de-facto	after you started with Molnupiravir?	01:04
ferret	yup	01:04
ferret	lol	01:04
de-facto	sigh not good :/	01:04
ferret	so none of us will leave the building	01:04
ferret	hopefully all of this will die here	01:04
ferret	long as it doesnt make it past this building	01:05
ferret	should be fine	01:05
ferret	your right molnupiravir should not be on the market	01:05
ferret	its a dangerious one	01:05
de-facto	it was my position from the begin on, but yeah here we are	01:05
de-facto	the Molnupiravir works by mimicking one of the ingredients of RNA and thereby introduces a lot of errors in it (mutations)	01:06
de-facto	at high enough concentrations that leads to replication deficit virions and thereby kills the infection	01:07
de-facto	but if its not high enough rates and such heavily mutated virions survive, even get passed on to other hosts it potentially could start a new Mutant	01:07
de-facto	https://en.wikipedia.org/wiki/Molnupiravir	01:08
ferret	de-facto: ouch	01:14
de-facto	ferret, now i am curious, what did they tell you when you got it prescribed?	01:16
ferret	nothing	01:16
LjL	IMO molnupiravir having been approves is more evidence of big pharma lobbying on FDA et al than any of the vaccine approvals	01:16
LjL	Approved*	01:17
ferret	i emailed the CDC about the situation hopefully they will get back	01:17
ferret	shouldnt have started using the drug in the first place	01:17
ferret	lol	01:17
LjL	ferret: what kind of individual prescribed it? Your GP, a specialist, just the pharmacy?	01:17
ferret	Doctor	01:17
LjL	Good question to ask that doctor would have been "what are the advantages of this for me compared to Paxlovid?"	01:18
de-facto	imho they should at least inform the patients on how it works and what the associated risks are, e.g. that they should isolate until recovery etc	01:18
ferret	they wouldnt precribe the alternative drug paxlovid it was strange	01:19
ferret	so the entire time i was wondering about this alternative drug molnupiravir	01:19
ferret	lol	01:19
de-facto	did they suggest it?	01:20
ferret	not at all	01:20
ferret	was at the hosptial after i had my O2 and heart rate checked after not being able to breath	01:20
de-facto	i mean did they suggest Molnupiravir usage or did you ask for prescription of it?	01:21
ferret	not at all asked for paxlovid and they precribed molnupiravir	01:21
ferret	something about not having any in stock	01:21
ferret	so precribed an alternative	01:21
LjL	Ah	01:22
de-facto	wow ok hmm	01:22
de-facto	did it at least make you better?	01:22
LjL	Here, it was announced that each pharmacy will receive one course of Paxlovid	01:22
LjL	If they get a second patient, they will have to reorder	01:23
LjL	Will see how it works out	01:23
ferret	never took the entire course. only used 6 pills out of 40	01:23
ferret	and well dropped one	01:24
ferret	so threw one pill away	01:24
ferret	:\|	01:24
ferret	nah im still super sick	01:24
ferret	lol	01:24
de-facto	sorry to hear that	01:24
de-facto	maybe you should consult with them again then	01:25
LjL	You started it, you have comorbidities that made them prescribe it to you (even if Paxlovid would have been preferable), maybe you really should finish the course...	01:25
LjL	Especially if you're still badly sick	01:26
de-facto	well yeah if you take it you should complete the whole sequence in isolation so no mutant could escape	01:27
de-facto	exactly like the plan is, e.g. without gaps etc	01:27
LjL	Well it's late for that :p	01:28
de-facto	doesnt matter if you drop a pill, the important thing is that there is no gap in the sequence	01:29
de-facto	yeah :/	01:29
de-facto	why dont they inform people prior to prescribing them such drugs	01:29
de-facto	they should be aware of the associated risks to avoid them	01:30
ferret	didnt even know there were drugs out there with consequences for stopping LOL	01:30
LjL	Medical system	01:30
LjL	ferret: there definitely are	01:30
de-facto	antibiotics you also should not stop early	01:30
LjL	Stop some psychiatric drugs without properly tapering off and you'll go legit bonkers	01:31
LjL	de-facto: my mom almost met the creator once after some kind of heart related episode. The ER took her blood and there was low, err, I hope I get the eight one because I always confuse them, potassium. So they IV'd potassium in. But then she had other episodes, and eventually she realized on her own (thanks to the internet, so much for doctors saying "dont look up medical things on the internet) that she was taking an antiepileptic for her	01:34
LjL	trigeminal neuralgia that could induce low potassium	01:34
de-facto	wow they should have catched that one in the medical history	01:35
LjL	It was written on the leaflet, but her neurologist who prescribed it didn't say it, her GP didn't say it, even the ER which did see she had low potassium DID NOT say it could be because of the drug (even though they had the full list of drugs she was taking)	01:35
LjL	Her neurologist was just surprised like "wow, that's a pretty rare effect"	01:35
LjL	Sure it's rare if you never catch it!	01:36
de-facto	i heard of someone that was taking those proton pump inhibitors (against reflux) for years and at some point developed serious neurological issues	01:36
de-facto	noone was telling him that it blocks the absorption of B12, so he was completely depleted of vitamin B12 to a point where he got neurological symptoms from it (its important for neurons etc)	01:37
de-facto	once he stopped that and got a few injections of B12 he is fine now	01:37
LjL	de-facto: okay I checked my bad memory and the med I'm taking about is carbamazepine (Tegretol) and the effect was on sodium (hyponatremia) not potassium	01:38
LjL	I need google to remember things right myself thanks to some lovely medications ;/	01:38
LjL	de-facto: he's lucky because nerve damage from B12 decificency can be very permanent	01:39
de-facto	yes he is very lucky	01:40
de-facto	its a known problem https://www.google.com/search?q=pantoprazol+b12	01:41
de-facto	imho some doctors should not work in their field of "expertise" if they fail so miserably to inform their patients about the therapies they suggest ot them	01:51
de-facto	many just do presrcipe stuff and dont even speak with their patients	01:52
de-facto	my GP got that option, to speak on the phone record and then he would give a prescription to take from the secretariat, i once needed antibiotic eyedrops and to my surprise he really did call back and talked through the therapy with me, informing me about risks and benefits etc	01:54
de-facto	was a bit proud of him doing that instead of just signing a prescription	01:54
LjL	you know, they have up to 1500 patients here and now even that limit has been waived after covid, so who knows how many patients they have	01:55
LjL	and so yes most what they do is printing out prescriptions and referrals	01:55
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): The "Delta" (L452R) mutation found in both the BA.2.12.1 and BA.4/BA.5 variants is key to both immune escape and enhanced cell fusion (not present in BA.1 or BA.2). And people with prior Delta infections have better neutralization to these variants [... want %more?] → https://twitter.com/EricTopol/status/1526711220429914113	01:58
de-facto	well yeah but then drugs that require a professional informative talk with the patient should not be prescribe-able by such GPs that just do high throughput signing of prescriptions	02:00
de-facto	e.g. normal doctors should not have the power of prescribing molnupiravir or such drugs	02:02
LjL	but then it means longer prescription times for things that need to be prescribed within 5 day of PCR	02:03
LjL	(or even of symptoms)	02:03
LjL	molnupiravir just shouldn't be a thing ;(	02:03
de-facto	obviously they are not capable of fulfilling the associated requirements on their expertise in terms of competence	02:04
de-facto	yes molnupiravir should not be a thing for exactly that reason	02:04
LjL	de-facto, they could also use much more automation. just look at freemedforms: if you are in the right country (i.e. France or the US, where the drug database are public domain or at least public), just having a patient file on it will immediately let you know if you're prescribing something that interact with something else they're taking, or with a condition they have	02:06
LjL	this software is here, public domain, free to use, what more do you want. no.	02:07
de-facto	well imho its exactly the reason whe have humans as MDs to employ their expertise and experience to the advantage of healing the patient while lowering the associated risks with a therapy	02:08
de-facto	if all could simply be done better by a computer program MDs would be obsolete	02:09
de-facto	hence for those MDs that fail to meet such requirements on their competence should not be allowed in that position imho	02:09
de-facto	maybe they should be send regularly "under cover test" patients	02:10
de-facto	and if they fail to meet the requirements loose their license	02:10
LjL	no human MD can just remember all of a patient's previous prescriptions	02:10
LjL	they also can't remember every interaction, and it takes time to look them up	02:11
LjL	and if they are specialists, they may remember interactions within the drugs in their field, but not with OTHER drugs	02:11
de-facto	well they could use of course the help of computers, but what offsets me here is that they prescribed molnupiravir without even telling ANY of the associated risks	02:11
LjL	databases are useful and we should use them	02:11
Brainstorm	Updates for Barbados: +469 cases, +1952 tests since a day ago — Zimbabwe: +317 cases since 21 hours ago	02:12
de-facto	such MDs should me removed from the healthcare system, they not only cause damage by their incompetence but also to the reputation of the whole profession	02:12
ferret	def	03:13
ferret	de-facto:	03:13
ferret	the room mate	03:13
ferret	he got paxlovid	03:13
ferret	thank goodness	03:13
ferret	hes a bit older	03:14
LjL	russian roulette	03:15
ferret	lol	03:16
ferret	im 23 hes like 70	03:19
de-facto	well yeah better Paxlovid but all small molecule drugs introduce selection pressure, if some (naturally occurring mutations) could replicate better under the replication suppressive drugs they would make that drug less effective for pathogen generations emerging from them	03:22
de-facto	so people under such treatment also should be isolated until they recovered	03:22
de-facto	while for Paxlovid the selection pressure mainly emerges from the presence of that substance (it inhibits a protease that is specific to SARS-CoV-2) with Molnupiravir (introducing a fatal mutation catastrophe in the RNA) the selection pressure still comes from the human biology and the hosts immune system, hence surviving mutations may potentially be optimized to function under such selection pressure	03:27
ferret	oh wow	03:30
ferret	so lets say they start the treatment and they start coughing i could get re infected with another strain on the other side of the house	03:31
ferret	the struggle is real	03:31
ferret	lol	03:31
ferret	de-facto: oh that is neat! Now i see the differences	03:32
Brainstorm	New from r/COVID19: COVID19: Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study → https://old.reddit.com/r/COVID19/comments/us1h30/antibody_responses_against_sarscov2_variants/	03:34
de-facto	Paxlovid is a small molecule that fits in a pocket of a protease that the replication chain of SARS-CoV-2 depends upon	03:34
de-facto	meaning any mutation changing that protease in a way that paxlovid does not fit so well into that while still being able to reproduce the virus will have a replication advantage under the selection pressure introduced by the presence of paxlovid	03:35
de-facto	hence its highly specific to SARS-CoV-2, advantage being it potentially could have less side effects, disadvantage that if possibly could be evaded by the virus if it can change that protease	03:37
de-facto	with Molnupiravir the mechanism works on a more basic level, e.g. RNA replication (of any kind) hence its not so specific to SARS-CoV-2 and thereby the probability of it evading the effect of the drug is much lower	03:38
de-facto	but the mechanism to introduce errors at a certain (concentration) specific rate into the RNA introduces the requirement to maintian a high enough concentration to really assure that all the virions replicaiton chains end up in the error catastrophe	03:39
de-facto	as long as the mutation rate is not so high the resulting virions still may be able to survive, hence replicate	03:40
de-facto	and that then would mean an increased "trial and error" rate bruteforcing whatever selection conditions are prevalent in the their replication environment, e.g. also the hosts biology and immune system	03:41
de-facto	at least that is how i understand it	03:41
de-facto	i should mention that i am not a medical or biology expert	03:41
ferret	de-facto: that is really interesting	03:42
ferret	so by me possibly creating mutant virus on this side of the house infecting the person on the other side with that mutant, it could evade paxlovid	03:43
de-facto	the selection pressure from paxlovid would create a mutant with increased replication capabilities under the influence of paxlovid, molnupiravir would increase the mutation rate and possibly create a mutant that would replicate better under the influence of human biology and immune system in general	03:46
de-facto	so possibly the mutants from paxlovid would not have any advantage in absence of paxlovid, while mutants from molnupiravir possibly could have advantages in replication for human biology and immune system pressure	03:47
de-facto	but that is just a possibility not a certain outcome, yet the reason why i think isolation in both cases should be mandatory, but especially in case of molnupiravir	03:47
ferret	thats intense	03:49
Brainstorm	Updates for Australia: +68238 cases, +65 deaths since 23 hours ago — Guatemala: +689 cases, +13 deaths, +8758 tests since a day ago — Grenada: +272 cases, +1404 tests since 2 days ago — Sint Maarten: +66 cases since 8 days ago	04:11
Brainstorm	New from r/COVID19: COVID19: Measuring Basic Reproduction Number to Assess Effects of Nonpharmaceutical Interventions on Nosocomial SARS-CoV-2 Transmission → https://old.reddit.com/r/COVID19/comments/us21iv/measuring_basic_reproduction_number_to_assess/	04:11
pimm	ferret: in the US you need to have 1 risk factor to get the Paxlovid	04:23
Brainstorm	New from COVID on Twitter: Jonathan Mesiano-Crookston #COVIDisAirborne (@jmcrookston): 1. pic.twitter.com/aOGO9fyTss → https://twitter.com/jmcrookston/status/1526750864613974016	04:40
Brainstorm	New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Also, while ICU numbers remain thankfully low, current hospitalizations for >70yo — now higher than Delta wave in NY and headed up elsewhere — suggest that widely boosting >70yo would meaningfully reduce morbidity and resource utilization pic.twitter.com/V5qgoR86NJ → https://twitter.com/michaelzlin/status/1526754658231783424	04:49
ferret	wow paxlovid looks cool. just picked up the meds again not for me	04:58
ferret	had night time and day time on each side	04:58
ferret	with like 3 pills	04:58
ferret	like 6 pills per each side	04:58
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): In the United States, 136,000 new confirmed cases today brings the 7-day average >100,000. Real number is esitmated to be ~700,000. And >500 more people hospitalized. No reason for concern, right @CDCgov? charts.medriva.com/us erictopol.substack.com/p/the-covid-ca… → https://twitter.com/EricTopol/status/1526758282806689793	04:59
ferret	im so lucky i didn't get covid toes	06:02
ferret	lol	06:02
Brainstorm	New from r/Science: science: Scientists use machine learning models to help identify long COVID patients → https://old.reddit.com/r/science/comments/us3hur/scientists_use_machine_learning_models_to_help/	06:24
ferret	thank you for all your help LjL and de-facto	07:11
ferret	i learned an important life lesson	07:11
ferret	lol	07:11
ferret	i hope the person on the other side of the house gets better soon. they started paxlovid today	07:13
ferret	were using GMRS handhelds so communicate when and who uses the kitchen and bathroom at different times	07:15
Brainstorm	New from Il Sole 24 Ore: (translated) Coronavirus, the next vaccine will be nasal: 8 companies are testing it: The second generation could guarantee more complete immunity and less chance that the infection will develop diseases in the organs → https://www.ilsole24ore.com/art/coronavirus-prossimo-vaccino-sara-nasale-8-aziende-sperimentano-AEu7eLZB	07:31
Brainstorm	Updates for Unknown, United Kingdom: +1819596 cases, +12071 deaths since 3 months ago — California, United States: +40916 cases, +88 deaths since a day ago — Western Australia, Australia: +16226 cases, +3 deaths since a day ago — Victoria, Australia: +14220 cases, +22 deaths since a day ago	08:03
Brainstorm	New from MedicineNet: (news): HPV 'Herd Immunity' Now Helping Vaccinated, Unvaccinated Women → http://www.medicinenet.com/script/main/art.asp	08:55
Brainstorm	Updates for United Kingdom: +1 deaths since 12 hours ago	09:00
Brainstorm	New from r/Coronavirus: Daily Discussion Thread \| May 18, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/us6zgg/daily_discussion_thread_may_18_2022/	09:05
de-facto	https://china.caixin.com/2022-05-17/101886284.html	09:06
de-facto	"Shanghai CDC denies excessive disinfecting practices in communities "	09:06
undefined_bob	but thats a lie, I guess?	09:18
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: Victorian schools hit with staff shortages amid COVID-19 and flu outbreaks → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/us7dpj/victorian_schools_hit_with_staff_shortages_amid/	09:33
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: Rutland Regional creates a COVID wing: as a dedicated negative pressure COVID-19 unit in response to an increase in local patienta → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/us7gkc/rutland_regional_creates_a_covid_wing_as_a/	09:42
Brainstorm	Updates for Taiwan: +85082 cases, +41 deaths, +151063 tests since 23 hours ago	10:02
Brainstorm	New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): @cookiebandit The low vaccination rate in seniors in Taiwan is finally getting attention where it's needed: In Taiwan. But with 85k cases today, maybe too late. h/t @chasewnelson english.cw.com.tw/article/articl… → https://twitter.com/michaelzlin/status/1526842121730203648	10:30
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: National Nurses United testifies at OSHA's hearing on occupational exposure to Covid-19 in healthcare settings: Since the beginning of 2022, each week, an average of 20,982 health care workers have been infected, [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/us8863/national_nurses_united_testifies_at_oshas_hearing/	10:40
Brainstorm	New from StatNews: Opinion: Does Paxlovid help people who have been vaccinated against Covid-19? Show us the data!: Doctors frustrated with their unvaccinated patients should stop shaking their fists at them and consider how the medical community has contributed to [... want %more?] → https://www.statnews.com/2022/05/18/does-paxlovid-help-people-who-have-been-vaccinated-against-covid-19/	10:50
Brainstorm	New from Reddit (test): Covid2019: Italian startup Almawave uses AI wearable to monitor COVID-19 patients -study → https://old.reddit.com/r/Covid2019/comments/us8fev/italian_startup_almawave_uses_ai_wearable_to/	10:59
Brainstorm	New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Differential Evasion of Delta and Omicron Immunity and Enhanced Fusogenicity of SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 SubvariantsPreprint: L452R mutation found in Delta, also in BA.2.12.1, BA.4, BA.5 is responsible for antibody escape and cell [... want %more?] → https://twitter.com/Marc_Veld/status/1526849487616065536	11:09
Brainstorm	New from Reddit (test): Covid2019: The strange COVID symptoms you might not have heard about \| 7NEWS → https://old.reddit.com/r/Covid2019/comments/us8yjo/the_strange_covid_symptoms_you_might_not_have/	11:37
Brainstorm	New from PubMed: GuLiM: A Hybrid Motion Mapping Technique for Teleoperation of Medical Assistive Robot in Combating the COVID-19 Pandemic: Driven by the demand to largely mitigate nosocomial infection problems in combating the coronavirus disease 2019 (COVID-19) pandemic, the trend of developing technologies for teleoperation of [... want %more?] → https://pubmed.ncbi.nlm.nih.gov/35582700/	11:57
Brainstorm	Updates for Israel: +1214 cases since 14 hours ago — Afghanistan: +149 cases, +2039 tests since 23 hours ago	12:01
Brainstorm	New from Il Sole 24 Ore: (translated) Another five years with the covid: here are the three possible scenarios between now and 2027: The greatest unknowns are linked to vaccination in the poorest countries, but international conflicts and little international [... want %more?] → https://www.ilsole24ore.com/art/altri-cinque-anni-il-covid-ecco-tre-possibili-scenari-qui-2027-AExX6MZB	12:07
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: Mental Health Issues Linked to Higher Risk of Breakthrough COVID Infections → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/us9v8u/mental_health_issues_linked_to_higher_risk_of/	12:45
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: Comparison of SARS-CoV-2 Antibody Response After 2-Dose mRNA-1273 vs BNT162b2 Vaccines in Incrementally Immunosuppressed Patients \| mRNA-1273 was more likely to induce stronger humoral immunogenicity compared with [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/usa9vl/comparison_of_sarscov2_antibody_response_after/	13:05
Brainstorm	Updates for UAE: +298 cases, +208015 tests since 21 hours ago	14:01
Brainstorm	New from COVID on Twitter: Madison Muller (@g0ingmad): NEW: Pfizer is resisting requests for study supplies of its Covid pill, Paxlovid, disappointing researchers who say combining the $22 billion therapy with other drugs might stave off resistance. With @RobertLangreth & @rileyraygriffin for [... want %more?] → https://twitter.com/g0ingmad/status/1526881843479515137	14:03
Brainstorm	New from Contagion Live: COVID-19 and MIS-C Severity vs Influenza and RSV in Children: Data on hospitalizations of children during the pandemic highlighted the seriousness of MIS-C, particularly in children of color. → https://www.contagionlive.com/view/covid-19-and-mis-c-severity-vs-influenza-and-rsv-in-children	14:33
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): Just published at @NatureThe title tells the story for tens of million Americans"Limited cross-variant immunity from #SARSCoV2 Omicron without vaccination"nature.com/articles/s4158…@TheOttLab @GladstoneInst @UCSF → https://twitter.com/EricTopol/status/1526907883383709697	14:52
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): What's missed by our fixation on hospitalization and death metrics for the pandemic—the disability toll—the impact by disability-adjusted life years (DALYs) nature.com/articles/d4158…@HollyElse @Nature #LongCovid pic.twitter.com/Fql0a4ObLH → https://twitter.com/EricTopol/status/1526909922868244480	15:02
Brainstorm	Updates for Croatia: +773 cases, +1 deaths since a day ago — Saudi Arabia: +602 cases, +2 deaths since a day ago — Brunei: +300 cases since a day ago — United Kingdom: +91 cases, +2 deaths since 19 hours ago	15:10
Brainstorm	New from StatNews: Pharma: STAT+: Pharmalittle: Moderna chair defends executive hiring process; analysis finds monopoly tactics preserve inhaler revenues → https://www.statnews.com/pharmalot/2022/05/18/covid19-vaccines-moderna-inhalers-hypertension-pfizer/	15:31
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): How Covid can affect our brain, with outstanding graphicsby @SarahNev @mroliverbarnes @ian_bott_artist ft.com/content/37b00a… @FT pic.twitter.com/KvRQECig1x → https://twitter.com/EricTopol/status/1526919482546958336	15:41
Brainstorm	Updates for Canada: +4027 cases, +24 deaths since 20 hours ago	16:00
Brainstorm	New from COVID on Twitter: ChristosArgyropoulos MD, PhD FlozinatorInChief (@ChristosArgyrop): The fact that the official announcement about the monkeypox from both UK and Portugal spend an inordinate amount of time saying it was seen among gay/bisexual men is reminiscent of the AIDS gay shaming from the [... want %more?] → https://twitter.com/ChristosArgyrop/status/1526923789841203201	16:01
Brainstorm	New from COVID on Twitter: terN95 (@1goodtern): @JT_Grindrod @LadyScorcher @jmcrookston @amandalhu @Suzanne43554675 @YouAreLobbyLud You should trust this without question. It's from the same reliable source that said dogs cause infant hepatitis. → https://twitter.com/1goodtern/status/1526937258212876289	16:51
Brainstorm	New from ClinicalTrials.gov: Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.: Conditions : COVID-19; Chronic Heart Failure; Hypertension; Arrhythmia; Conduct Disorder; Chronic Coronary Syndrome; Endothelial Dysfunction; [... want %more?] → https://clinicaltrials.gov/ct2/show/NCT05379608	17:12
Brainstorm	Updates for Germany: +69736 cases, +141 deaths since 23 hours ago	17:59
Brainstorm	New from ClinicalTrials.gov: Older Adults' Perceptions of the Impact COVID-19 Pandemic: Conditions : COVID-19 Pandemic; Depression, Anxiety; Cognitive Impairment; Quality of Life; Loneliness → https://clinicaltrials.gov/ct2/show/NCT05379426	18:11
Brainstorm	New from ClinicalTrials.gov: (news): Echocardiographic Manifestation in Patients With Omicron Variant of COVID-19 → https://clinicaltrials.gov/ct2/show/NCT05379543	18:20
Brainstorm	New from ClinicalTrials.gov: (news): LOng COvid COmorbidities: Andrological, Reproductive, Sexual Dysfunctions (LO-COCO-ANDRO) → https://clinicaltrials.gov/ct2/show/NCT05379556	18:30
Brainstorm	New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Once more;Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccinationInfection is NOT better than vaccination: never was!(mice).nature.com/articles/s4158… → https://twitter.com/Marc_Veld/status/1526967767605424128	18:50
Brainstorm	Updates for Ireland: +16384 cases, +41 deaths since 5 days ago — Chile: +5137 cases, +21 deaths, +80155 tests since 23 hours ago — Italy: +30927 cases, +136 deaths, +264273 tests since a day ago — Canada: +5080 cases, +25 deaths since 23 hours ago	19:08
Brainstorm	New from Contagion Live: First In-Africa Clinical Trial of mRNA HIV Vaccine: Today, the International AIDS Vaccine Initiative (IAVI) and Moderna announced they will soon launch a phase 1 clinical trial for their HIV vaccine candidate, administered with mRNA technology to develop broadly [... want %more?] → https://www.contagionlive.com/view/first-in-africa-clinical-trial-of-mrna-hiv-vaccine	19:10
Brainstorm	New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Fast increase of Omicron BA.4 & BA.5 genomes @GISAID, now > 30 countries, > 3,000 genomes. New detections in Thailand, Iceland, Luxembourg, Norway, Sweden, Costa Rica, and Chile. Highest prevalence outside Africa: Portugal, highest number of genomes: USA, U.K., [... want %more?] → https://twitter.com/Tuliodna/status/1526979889554984964	19:40
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: COVID-19 infection can cause unusual digestive symptoms: Experts - nausea, vomiting, or diarrhoea — either alone or with other COVID-19 symptoms. Sometimes, digestive symptoms develop before fever and respiratory symptoms → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/usip9q/covid19_infection_can_cause_unusual_digestive/	20:00
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): A @NatureMedicine tour de force review of the unexplained post-acute infectious syndromes, which includes #LongCovid and many others nature.com/articles/s4159…by @jan_choutka @mhornig @VirusesImmunity pic.twitter.com/dhYeZYnM1U → https://twitter.com/EricTopol/status/1526985938936573953	20:09
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): How the extraordinary South African life scientists keep on top of the pandemic and provide invaluable insights for the rest of the worldwsj.com/articles/as-ne…by @deniseroland @aaishadadipatel w/ @Tuliodna @sigallab pic.twitter.com/Mi8yVfuqua → https://twitter.com/EricTopol/status/1526989997932281858	20:19
Brainstorm	New from Reddit (test): Covid2019: UPDATE 3-As U.S. COVID-19 cases rise, so does demand for antivirals - Paxlovid seeing a 315% jump over the past four weeks, → https://old.reddit.com/r/Covid2019/comments/usjij3/update_3as_us_covid19_cases_rise_so_does_demand/	20:39
Brainstorm	New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Unexplained post-acute infection syndromesA very comprehensive review of long-term effect after infection, including LongCOVID. nature.com/articles/s4159… → https://twitter.com/Marc_Veld/status/1526995347368722433	20:48
Brainstorm	Updates for France: +64492 cases, +80 deaths since 22 hours ago — Japan: +37163 cases, +50 deaths since 13 hours ago	21:07
Brainstorm	New from Reddit (test): Covid2019: USA TODAY broadens access to report card rating COVID outcomes at nursing homes during surge → https://old.reddit.com/r/Covid2019/comments/usk6ks/usa_today_broadens_access_to_report_card_rating/	21:09
Brainstorm	New from WebMD: (news): New Pandemic Peril? Pretending It's Over as Case Numbers Rise → https://www.webmd.com/lung/news/20220518/not-out-of-covid-yet-experts	21:19
Brainstorm	New from COVID19 Vaccine Tracker: valerie: Airlangga University: UNAIR Inactivated COVID-19 Vaccine → https://covid19.trackvaccines.org/vaccines/181/	21:29
Brainstorm	New from Reddit (test): Covid2019: After Unvaccinated Pregnant Woman Dies of COVID, Family Urges Vaccinations → https://old.reddit.com/r/Covid2019/comments/uskswu/after_unvaccinated_pregnant_woman_dies_of_covid/	21:40
Brainstorm	New from Reddit (test): CoronaVirus_2019_nCoV: 2 years into COVID-19, some remain in complete isolation - "People will go to marathons and wear ribbons for people with cancer, but a mask is too much to ask. It's ridiculous," → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/usl4ly/2_years_into_covid19_some_remain_in_complete/	21:49
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): New on Paxlovid relapse, being reported w/ increased frequency as use has risen In-depth assessment of a case No sign of resistance or lack of neutralizing antibody. "most likely possibility for the observed recrudescence is insufficient drug [... want %more?] → https://twitter.com/EricTopol/status/1527015060090277888	22:00
Brainstorm	New from CIDRAP: COVID-19 Scan for May 18, 2022: Severe COVID and kids' heart conditions COVID vaccines and variants → https://www.cidrap.umn.edu/news-perspective/2022/05/covid-19-scan-may-18-2022	22:39
Brainstorm	Updates for Missouri, United States: +16889 cases, +137 deaths since 15 hours ago — United Kingdom: +543 cases, +2 deaths since 14 hours ago	23:06
Brainstorm	New from COVID on Twitter: Eric Topol (@EricTopol): Note the Deltacron assessed is absent the key L452R mutation seen in Delta, BA.2.12.1 (L452Q) and BA.4/BA.5. Not present in BA.1, BA.2, BA.3 pic.twitter.com/K3X1pZrgIS → https://twitter.com/EricTopol/status/1527032007947001856	23:08
Brainstorm	New from CIDRAP: On-campus COVID-19 measures couldn't contain Omicron: Mary Van Beusekom \| News Writer \| CIDRAP News May 18, 2022 Though vaccination protected against severe illness, it did not prevent rapid spread, the authors say. → https://www.cidrap.umn.edu/news-perspective/2022/05/campus-covid-19-measures-couldnt-contain-omicron	23:18
Jigsy	So Monkeypox is the new COVID...	23:25
Brainstorm	New from CIDRAP: As US battles COVID rise, officials press for resources for next surge: Lisa Schnirring \| News Editor \| CIDRAP News May 18, 2022 Officials say funds are needed to get vaccines and treatments ready for potential fall and winter activity. → https://www.cidrap.umn.edu/news-perspective/2022/05/us-battles-covid-rise-officials-press-resources-next-surge	23:28
Brainstorm	New from COVID on Twitter: Prof. Akiko Iwasaki (@VirusesImmunity): What could be the possible causes of PAIS? Similar to #longCOVID, we hypothesize a) pathogen reservoir/remnants, b) autoimmunity, c) dysbiosis of microbiome/virome, and d) unrepaired tissue damage. None are mutually exclusive. (6/) pic.twitter.com/JaPzK7AHWe → https://twitter.com/VirusesImmunity/status/1527044323917070336	23:58

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