libera/##covid-19/ Saturday, 2022-06-04

BrainstormUpdates for Aruba: +941 cases, +3 deaths since 6 days ago00:02
BrainstormNew from Reddit (test): Covid2019: Covid: Peterborough kidney patient still shielding: Kidney transplant patient Brian Platts, 70, from Peterborough, wants access to Evusheld which includes pre-formed antibodies and lasts six months. - BBC News → https://old.reddit.com/r/Covid2019/comments/v4a22t/covid_peterborough_kidney_patient_still_shielding/00:03
BrainstormUpdates for Bahrain: +595 cases, +3982 tests since 23 hours ago — Kenya: +150 cases, +2999 tests since a day ago — Germany: +7308 cases, +11 deaths since 7 hours ago — Montenegro: +66 cases, +667 tests since a day ago01:05
BrainstormNew from r/COVID19: COVID19: Viral Load Rebound in Placebo and Nirmatrelvir-Ritonavir Treated COVID-19 Patients is not Associated with Recurrence of Severe Disease or Mutations → https://old.reddit.com/r/COVID19/comments/v4bszr/viral_load_rebound_in_placebo_and/01:30
BrainstormUpdates for Brazil: +36189 cases since 23 hours ago — North Dakota, United States: +838 cases since 23 hours ago — Morocco: +425 cases, +23181 tests since a day ago — Zambia: +292 cases, +1 deaths, +2519 tests since a day ago02:08
BrainstormUpdates for Malaysia: +1844 cases, +1 deaths, +41778 tests since a day ago — Canada: +1573 cases since 10 hours ago03:04
BrainstormNew from r/Science: science: The incredible antibodies of sharks, llamas and camels | Feature → https://old.reddit.com/r/science/comments/v4dodx/the_incredible_antibodies_of_sharks_llamas_and/03:43
BrainstormUpdates for Guatemala: +839 cases, +18 deaths since a day ago04:07
BrainstormNew from r/Science: science: Removing barriers to opioid use disorder treatment shows success during pandemic → https://old.reddit.com/r/science/comments/v4e7zz/removing_barriers_to_opioid_use_disorder/04:31
BrainstormNew from This Week In Virology: TWiV 905: COVID-19 clinical update #117 with Dr. Daniel Griffin: In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab [... want %more?] → https://www.microbe.tv/twiv/twiv-905/06:08
BrainstormUpdates for Japan: +12279 cases, +2 deaths, +233121 tests since 8 hours ago07:02
BrainstormUpdates for Florida, United States: +57566 cases, +2 deaths since 23 hours ago — Puerto Rico, United States: +7057 cases, +10 deaths since 23 hours ago — Minas Gerais, Brazil: +6886 cases since 23 hours ago — Metropolitana, Chile: +5258 cases, +6 deaths since 23 hours ago07:59
BrainstormNew from r/COVID19: COVID19: COVID-19 Vaccination-Induced Cardiomyopathy Requiring Permanent Left Ventricular Assist Device → https://old.reddit.com/r/COVID19/comments/v4is9w/covid19_vaccinationinduced_cardiomyopathy/08:40
BrainstormNew from r/Coronavirus: Daily Discussion Thread | June 04, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/v4jcnk/daily_discussion_thread_june_04_2022/09:10
BrainstormNew from Il Sole 24 Ore: (translated) Analyzes, ultrasound scans, vaccines and visits: this is what can be done in community homes: They are the heart of the NRP: family doctors and pediatricians, nurses, other specialists, rehabilitation technicians, social [... want %more?] → https://www.ilsole24ore.com/art/analisi-ecografie-vaccini-e-visite-ecco-cosa-si-potra-fare-case-comunita-AEqpFfdB09:49
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Covid Scotland: Record numbers infected in hospital during BA.2 wave | HeraldScotland → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/v4kl22/covid_scotland_record_numbers_infected_in/10:36
BrainstormNew from Politico: Can long Covid lead to death? A new analysis suggests it could: The CDC is beginning to look at death certificates that indicate more than 100 people who died had long Covid. → https://www.politico.com/news/2022/06/03/can-long-covid-lead-to-death-a-new-analysis-suggests-it-could-0003684512:11
BrainstormUpdates for Russia: +4101 cases, +82 deaths since a day ago13:06
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Fully vaccinated individuals had a shorter duration of viable viral shedding and a lower rate of secondary transmission than partially vaccinated or unvaccinated individuals. pic.twitter.com/8WJTRX1Qjq → https://twitter.com/Marc_Veld/status/153304359812768563313:18
BrainstormNew from Pfizer: Anonymous: Pfizer Announces Overall Survival Results from Phase 3 PALOMA-2 Trial of IBRANCE  (palbociclib) for the First-Line Treatment of ER+, HER2- Metastatic Breast Cancer → https://www.pfizer.com/news/press-release/press-release-detail/pfizer-announces-overall-survival-results-phase-3-paloma-214:06
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 04JUN22 → https://old.reddit.com/r/nCoV/comments/v4nywq/global_covid_cases_for_04jun22/14:44
BrainstormUpdates for Slovenia: +294 cases since 14 hours ago16:02
BrainstormNew from Contagion Live: HIV Infection Increases Odds of Severe COVID-19: The study authors determined that COVID-19 patients with HIV were 38% more likely to die than those without HIV. → https://www.contagionlive.com/view/hiv-infection-increases-odds-of-severe-covid-1916:03
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): First study of Paxlovid in vaxxed people shows a significant benefit in preventing hospitalization for those over 65yo, but not for younger.The study was independent of Pfizer, used real-world data. Done in Israel of course (US seems incapable of [... want %more?] → https://twitter.com/michaelzlin/status/153308984439760896016:22
BrainstormNew from COVID on Twitter: Josiah Grindrod is usually self limiting (@JT_Grindrod): This should be an easy W for public health. Our pitiful response to SARS accidentally drove a flu strain to extinction, monkeypox is a dunk on a 3 foot net by comparison.The window to eliminate closed the second it got here [... want %more?] → https://twitter.com/JT_Grindrod/status/153309761196768051216:51
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The "S" word for the pandemic is subvariants. Who even heard or used this word prior to Omicron's descendants? 6 weeks ago the US was in the best shape since it all started. Then came BA.2, now BA.2.12.1, and next up BA.4, BA.5. pic.twitter.com/CwdlEZMdWJ → https://twitter.com/EricTopol/status/153310043653354291417:01
BrainstormUpdates for Brunei: +379 cases since a day ago17:05
LjL%print https://twitter.com/comilla_s/status/153310173189400576117:30
BrainstormLjL, It says: Dr. Comilla su Twitter: "I have more patients, family and friends, with #covid now then on Dec/Jan. Many who were previously infected during the #omicron initial surge. The vast majority testing at home (which is great for controlling spread), but our case numbers are dramatically lower than in reality.… https://t.co/ruQO2oBErB"17:30
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A distinct post-Covid phenotype with smell and taste dysfunction is associated with better recovery #LongCovid "This stresses the heterogeneity of post-acute Covid sequelae, each requiring tailored management strategies"medrxiv.org/content/10.110… pic.twitter.com/fz8xaR80te → https://twitter.com/EricTopol/status/153311038060768051217:39
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): So if you're <65yo and have some immunity (which is nearly everyone now), the data reveal that there's no discernable benefit to getting Paxlovid, even if you have preexisting conditions.Don't expect Pfizer to trumpet these results as it removes the [... want %more?] → https://twitter.com/michaelzlin/status/153311111519380685017:48
LjLwell this is a disappointing finding (Lin)17:55
BrainstormUpdates for Germany: +36256 cases, +58 deaths since 23 hours ago18:05
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The @Novavax vaccine @US_FDA documentsfda.gov/media/158912/d…Good efficacy (pre-Omicron) vs all infections pic.twitter.com/pzrNwjCRBa → https://twitter.com/EricTopol/status/153311738789711462418:07
BrainstormNew from r/Science: science: Sleep disturbances, fatigue common in patients who recovered from COVID. More than two-thirds of patients (67.2%) reported at least moderate fatigue, while 21.8% reported severe fatigue. Eight percent reported severe sleep disturbances, and 41.3% [... want %more?] → https://old.reddit.com/r/science/comments/v4ryi4/sleep_disturbances_fatigue_common_in_patients_who/18:18
BrainstormNew from r/COVID19: COVID19: Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial → https://old.reddit.com/r/COVID19/comments/v4sjjk/baricitinib_versus_dexamethasone_for_adults/18:37
BrainstormUpdates for Italy: +22809 cases, +47 deaths since a day ago — Canada: +2487 cases, +37 deaths since 21 hours ago19:07
BrainstormNew from r/COVID19: COVID19: The impact of COVID-19 on essential health service provision for endemic infectious diseases in the South-East Asia region: A systematic review → https://old.reddit.com/r/COVID19/comments/v4tjw7/the_impact_of_covid19_on_essential_health_service/19:45
BrainstormUpdates for Chile: +9890 cases, +23 deaths since 22 hours ago20:04
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): 2022.05.31: On how SF is seeing all-time highest SARSCoV2 levels (in wastewater). ICU levels are low, but disease is everywhere. Good time to mask up. You can probably reduce long COVID risk by reducing inhaled dose.twitter.com/michaelzlin/st… → https://twitter.com/michaelzlin/status/153314638017619558420:04
BrainstormNew from r/Science: science: The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients—A Large Population-Based Study → https://old.reddit.com/r/science/comments/v4v1n9/the_incidence_of_myocarditis_and_pericarditis_in/21:11
BrainstormNew from r/COVID19: COVID19: Two Pandemic Years Have Created a PPE Wasteland → https://old.reddit.com/r/COVID19/comments/v4vz96/two_pandemic_years_have_created_a_ppe_wasteland/21:21
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Last week Pfizer completed submitting data to FDA on their vax for <5-year-olds, >1mo after Moderna. The more I chew on the whole <5yo vax issue, the worse it tastes. In fact it seems like moving the goalposts to favor one company in the most [... want %more?] → https://twitter.com/michaelzlin/status/153317893037859635222:19
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Pfizer initially had a 2-dose vaccine regimen. They obtained results in December on clinical outcomes (preventing cases) and they were not good. Initially they hoped to apply in December but instead extended the trial to a 3rd dosemedscape.com/viewarticle/96… → https://twitter.com/michaelzlin/status/153318160058576896022:29
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Anyway in this pandemic, I'd have no problem extending a trial to get more efficacy, as long as the statistical methods are robust.But what's unusual here is that FDA gave Pfizer two ways to get approval, and expedited it both times.That contrasts [... want %more?] → https://twitter.com/michaelzlin/status/153318520634500710422:38
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): FDA encouraged a formal application from Pfizer, with the thinking that even if 2 doses wasn't that effective, since there were no alternatives, the only hope is that a 3rd dose would help, and in that case we might as well get started. [... want %more?] → https://twitter.com/michaelzlin/status/153318759398198886522:48
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): The 1st way was when FDA asked Pfizer to submit their 2-dose data in February. They even scheduled a VRBPAC advisory meeting to discuss the data, before cancelling it.This was before Moderna finished collecting their 2-dose data.medscape.com/viewarticle/96… → https://twitter.com/michaelzlin/status/153318979680106496222:57
BrainstormUpdates for Morocco: +438 cases, +1 deaths, +7613 tests since 20 hours ago — Canada: +2513 cases, +48 deaths since 23 hours ago23:06
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Not surprisingly, on 2022 March 23, Moderna announced their 2-dose trial in 2-5yo *succeeded* in achieving the prespecified immunological endpoint of similar antibody levels as 18-25yo adultstwitter.com/michaelzlin/st… → https://twitter.com/michaelzlin/status/153319299107389849723:07
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): FDA could have then approved Pfizer 3mcg for 0.5-2yo and Moderna 25mcg for 2-4yo. But they didn't. In fact FDA received Moderna's application in late April, and then sat on it for more than a month.pbs.org/newshour/healt… → https://twitter.com/michaelzlin/status/153319477515050598423:17
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): So what do we have here? A situation where it seems Pfizer not only gets two shots on goal, but also where a successful shot by the competition gets held for evaluation until Pfizer gets that second shot.It's heads Pfizer wins, tails we flip again. → https://twitter.com/michaelzlin/status/153319747846748979223:26
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): And meanwhile who has suffered? Parents of young kids, who could have gotten those first shots in February or March, who now must wait until July, 5 months later. Because Pfizer apparently must always win. → https://twitter.com/michaelzlin/status/153319841554637209723:36
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): And meanwhile who has suffered? Young kids and their parents. They could have gotten those first shots in February or March, but now must wait until July, 5 months later. Because Pfizer apparently must always win. → https://twitter.com/michaelzlin/status/153320141816887296023:46

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