Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Meanwhile Pfizer's standard NDA of Paxlovid should be sent back because it's entirely based on unvaxxed pre-Omicron resultspfizer.com/news/press-rel… → https://twitter.com/michaelzlin/status/1542267444651126784 | 00:08 |
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de-facto | %title https://arstechnica.com/science/2022/06/fauci-reports-covid-rebound-says-its-much-worse-than-initial-illness/ | 00:08 |
Brainstorm | de-facto: From arstechnica.com: Fauci reports COVID rebound, says his is “much worse” than initial illness | Ars Technica | 00:09 |
LjL | de-facto, uhm i hope this paxlovid rebound phenomenon isn't more common than it seemed | 00:34 |
LjL | and that having worse disease also isn't | 00:34 |
LjL | it's such a promising drug | 00:34 |
de-facto | well every drug will only have limited effectivity as it puts selection pressure on the pathogen | 00:39 |
Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): A new systematic review on long distance (>2 meters, 6.6 ft) airborne transmission: the importance of adequate ventilation to prevent Covid for indoor venuesbmj.com/content/377/bm… @bmj_latest by @daph_duval and colleagues#COVIDisAirborne pic.twitter.com/4r4ifSYLll → https://twitter.com/EricTopol/status/1542274461101178881 | 00:39 |
de-facto | it can work for some time, but the more its used the less effective its going to become | 00:39 |
de-facto | yes its a promising drug, but no single drug will solve the covid problem | 00:42 |
de-facto | it can help to some extend only | 00:42 |
Brainstorm | Updates for Brazil: +75797 cases, +225 deaths since 23 hours ago — Guatemala: +4342 cases, +19 deaths since 23 hours ago — Bahrain: +2008 cases, +7099 tests since 23 hours ago — Lebanon: +1399 cases, +1 deaths since a day ago | 01:03 |
Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): SARSCoV2 can mutate a lot and remain functional. That's how we got Omicron to be so diverged immunologically from Wuhan, almost as diverged as SARSCoV1. That happens even without MOV, but MOV has little/no clinical benefit, and now we see harm in action. → https://twitter.com/michaelzlin/status/1542283367059582976 | 01:10 |
Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Plus there *is* evidence SARSCoV2 mutants are selected for survival during MOV treatment in the host. In Merck's ECCMID poster, we see mutations are enriched in spike and higher than placebo. Thus selection occurs (e.g. for entry or immunoevasion) [... want %more?] → https://twitter.com/michaelzlin/status/1542285933411651584 | 01:20 |
Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Extrapolating outcomes from S Africa to other countries is difficult b/o marked differences in multiple demographics, such as age, % prior infections. But what has largely been missed is the impact of mass Beta variant exposure, the strain w/ most immune escape [... want %more?] → https://twitter.com/EricTopol/status/1542288171601252354 | 01:30 |
Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Detailed outbreak transmission assessment of all of these 18 reports in the following settings:restaurants, singing events, department store, courtroom, abatement block, quarantine hotel, bus, meat processing plant, office pic.twitter.com/eclb3AMKdl → https://twitter.com/EricTopol/status/1542289761762549762 | 01:41 |
Brainstorm | Updates for Isle of Man: +2642 cases since 8 days ago — Guyana: +104 cases, +2 deaths since 21 hours ago — Canada: +2612 cases, +23 deaths since 22 hours ago | 02:00 |
LjL | %print https://twitter.com/EricTopol/status/1542153188828135426 | 02:18 |
Brainstorm | LjL, It says: Eric Topol on Twitter: "Yesterday we learned Tony Fauci had Paxlovid rebound, a common problem, and is taking a 2nd Rx course. He'll do well. But today we learn about 11 naturally occurring mutations of Mpro, the target of Paxlovid, which could confer resistance in the future https://t.co/mDfZsIC9dw https://t.co/3cG55VSuHY" / Twitter | 02:18 |
de-facto | %title https://www.biorxiv.org/content/10.1101/2022.06.28.497978v1 | 02:23 |
Brainstorm | de-facto: From www.biorxiv.org: Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir | bioRxiv | 02:23 |
Brainstorm | Updates for Norway: +740 cases since 22 hours ago — Slovakia: +676 cases since 14 hours ago — France: +148 cases since 5 hours ago | 03:02 |
Brainstorm | New from r/COVID19: COVID19: Seasonal coronaviruses and SARS-CoV-2: effects of preexisting immunity during the COVID-19 pandemic → https://old.reddit.com/r/COVID19/comments/vnvfu6/seasonal_coronaviruses_and_sarscov2_effects_of/ | 03:43 |
Brainstorm | Updates for Australia: +49079 cases, +89 deaths since 23 hours ago — Albania: +581 cases since 13 hours ago — San Marino: +194 cases since 2 days ago | 03:59 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Triple vaccination seems to reduce the chance of long COVID – but we still need to prepare for a jump in cases → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vnxg2z/triple_vaccination_seems_to_reduce_the_chance_of/ | 04:44 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: "higher markers of inflammation in the cerebral spinal fluid, but in some people, we're also seeing markers of vascular dysregulation, or that the blood cells within the brain compartment aren't acting and behaving normally" → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vnxlk8/higher_markers_of_inflammation_in_the_cerebral/ | 04:54 |
Brainstorm | Updates for Kazakhstan: +140 cases since 18 hours ago | 05:01 |
Brainstorm | Updates for Germany: +132671 cases, +83 deaths since 23 hours ago — Mexico: +23148 cases, +31 deaths, +38115 tests since a day ago — Thailand: +2695 cases, +14 deaths since a day ago | 06:10 |
Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Unfortunate timing on that headline from 2 days ago Coming down with bad rebound COVID-19 after taking 4 vaccine doses and Paxlovid definitely doesn't sound like a waning pandemicI just happened to notice it and thought it was an old story but [... want %more?] → https://twitter.com/michaelzlin/status/1542359527697178625 | 06:20 |
Brainstorm | Updates for Bolivia: +1573 cases since 22 hours ago — Pakistan: +641 cases, +18813 tests since 22 hours ago — Venezuela: +195 cases, +2 deaths since 2 days ago | 07:07 |
Brainstorm | Updates for Lombardy, Italy: +25132 cases, +9 deaths since a day ago — Georgia, United States: +20971 cases, +132 deaths since 7 days ago — Victoria, Australia: +20509 cases, +40 deaths since 2 days ago — Bavaria, Germany: +20360 cases, +14 deaths since a day ago | 08:10 |
Brainstorm | New from r/Coronavirus: Daily Discussion Thread | June 30, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/vo20gi/daily_discussion_thread_june_30_2022/ | 09:02 |
Brainstorm | New from Science-Based Medicine: Moral outrage is not a good guide to pandemic policy reform. Vinay Prasad, please take note.: Vinay Prasad identifies some dubious problems in the government's efforts to protect public health, and offers some [... want %more?] → https://sciencebasedmedicine.org/moral-outrage-is-not-a-good-guide-to-pandemic-policy-reform-vinay-prasad-please-take-note/ | 09:50 |
Brainstorm | New from EMA: What's new: Orphan: Orphan designation: Recombinant human monoclonal antibody to insulin receptor, Treatment of congenital hyperinsulinism, 14/07/2016, Positive → https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-16-1702 | 10:29 |
Brainstorm | New from BMJ: Seven days in medicine: 22-28 June 2022: AbortionUS Supreme Court ends constitutional right to abortionDoctors condemned the US Supreme Court’s 24 June ruling to overturn the 1973 Roe v Wade decision, thus ending women’s 50 year old constitutional right to abortion and leaving the issue for individual states [... want %more?] → http://www.bmj.com/content/377/bmj.o1574.short | 10:49 |
Brainstorm | Updates for Japan: +12369 cases, +3 deaths, +146957 tests since 14 hours ago — Israel: +6093 cases since 14 hours ago — Kerala, India: +4459 cases, +17 deaths since a day ago — Karnataka, India: +1945 cases, +2 deaths since a day ago | 11:05 |
Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): This systematic review found evidence of long distance airborne transmission of SARS-CoV-2 & found that insufficient air replacement probably contributed to transmission.The results demonstrate the importance of adequate ventilation & other mitigation [... want %more?] → https://twitter.com/GANyborg/status/1542435775962390530 | 11:18 |
Brainstorm | New from BMJ: Trust in vaccines . . . and other stories: Improving vaccine uptakeA survey of doctors in the Czech Republic finds, not surprisingly, that they have a high degree of trust in vaccines against covid-19. This is at odds with the results of a... → http://www.bmj.com/content/377/bmj.o1532.short | 11:46 |
Brainstorm | New from COVID on Twitter: (translated) Gunhild Alvik Nyborg (@GANyborg): Does no one see what is going on? A large proportion of the population has recently undergone at least one COVID infection. This causes cognitive problems in many and increased risk of stroke, arrhythmias and dizziness @tryggtrafikk nrk.no/dokumentar/xl/… → https://twitter.com/GANyborg/status/1542445626864148480 | 11:56 |
Brainstorm | Updates for Russia: +3106 cases, +56 deaths since 23 hours ago — Afghanistan: +125 cases, +1 deaths, +1035 tests since 23 hours ago | 12:02 |
Brainstorm | New from ScienceNews: New COVID-19 boosters could contain bits of the omicron variant: The omicron variant is different enough from the original version to require an update to COVID-19 vaccines, experts say. → https://www.sciencenews.org/article/covid-vaccine-booster-omicron-variant-coronavirus | 12:06 |
Brainstorm | New from COVID on Twitter: (translated) Gunhild Alvik Nyborg (@GANyborg): @tryggtrafikk It is now established knowledge that very many (most studies find about 1/3 in the studies that are available so far) are affected by cognitive functions after COVID. Norway must soon wake up: SARS-CoV-2 attacks the brain. [... want %more?] → https://twitter.com/GANyborg/status/1542452045478862848 | 12:26 |
Brainstorm | New from COVID on Twitter: (translated) Gunhild Alvik Nyborg (@GANyborg): @tryggtrafikk And here you will find an accumulation of substances in COVID that are very toxic to nerve cells, of the same type as in neurodegenerative diseases such as Alzheimer's and Parkinson's.nature.com/articles/s4146… → https://twitter.com/GANyborg/status/1542453955908739073 | 12:35 |
Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): @tryggtrafikk En til. Jeg driver ikke cherry-picking. Søvnvansker er vanlig, obs v bilkjøring! "The covid-19 group also showed an increased risk of incident neurocognitive decline and sleep disorders.... The risk of any incident mental health diagnosis... [... want %more?] → https://twitter.com/GANyborg/status/1542459594995269633 | 12:55 |
Brainstorm | Updates for UAE: +1778 cases, +1 deaths, +288743 tests since 22 hours ago — Iran: +529 cases, +3 deaths since 21 hours ago | 14:01 |
Brainstorm | New from r/COVID19: COVID19: COVID-19 cases rising in 110 countries, warns WHO → https://old.reddit.com/r/COVID19/comments/vo6lqx/covid19_cases_rising_in_110_countries_warns_who/ | 14:03 |
Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 30JUN22 → https://old.reddit.com/r/nCoV/comments/vo6udl/global_covid_cases_for_30jun22/ | 14:13 |
Brainstorm | New from r/Coronavirus: Coronavirus: COVID-19 boosters recommended for the fall, Canada's vaccine advisory body says → https://old.reddit.com/r/Coronavirus/comments/vo794h/covid19_boosters_recommended_for_the_fall_canadas/ | 14:52 |
Brainstorm | Updates for Hong Kong: +2358 cases, +2 deaths since 22 hours ago — Indonesia: +2248 cases, +6 deaths, +79384 tests since a day ago — Bangladesh: +2187 cases, +13905 tests since 22 hours ago — Croatia: +1148 cases, +5 deaths, +3532 tests since a day ago | 15:04 |
Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Pfizer and U.S. strike $3.2 billion deal for Covid vaccine; marketing of morning-after pills shifts to mail-order options → https://www.statnews.com/pharmalot/2022/06/30/covid19-vaccines-pfizer-contraception-insulin-lilly-novartis-opioids-walmart/ | 15:31 |
Brainstorm | New from COVID on Twitter: Tom Peacock (@PeacockFlu): Spike mutation-wise its got normal BA.2 mutations + K147E, W152R, F157L, I210V, G257S, G339H, G446S, N460K and reversion of R493Q - none of these individually really flag as that worrying but all appearing together at once is another matter... → https://twitter.com/PeacockFlu/status/1542502228505767937 | 15:42 |
Brainstorm | New from COVID on Twitter: Tom Peacock (@PeacockFlu): worth saying its entirely possible this is just growing against a background of BA.2(.12.1) and that it hits the encroaching wall of BA.5 and stalls out... we will see → https://twitter.com/PeacockFlu/status/1542506522713829377 | 16:02 |
Brainstorm | Updates for Philippines: +1307 cases, +13 deaths, +24154 tests since a day ago | 16:06 |
Brainstorm | New from FDA Press Releases: Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses: The FDA has advised manufacturers seeking to update their COVID-19 [... want %more?] → http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster | 16:21 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Antivaxx MAGA preacher says if he's elected to the U.S. Senate, he's going to have Fauci convicted of crimes against humanity: "Fauci is one of the greatest mass murderers in human history, worse than Hitler and Stalin!" → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vo9n57/antivaxx_maga_preacher_says_if_hes_elected_to_the/ | 16:31 |
Brainstorm | New from r/COVID19: COVID19: Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial → https://old.reddit.com/r/COVID19/comments/vo9ymw/enoxaparin_for_primary_thromboprophylaxis_in/ | 16:41 |
Brainstorm | New from r/COVID19: COVID19: Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses → https://old.reddit.com/r/COVID19/comments/voa3l3/coronavirus_covid19_update_fda_recommends/ | 16:51 |
Brainstorm | Updates for Singapore: +9505 cases since 19 hours ago — Iraq: +2769 cases, +2 deaths since a day ago — Serbia: +921 cases, +1 deaths, +7441 tests since 22 hours ago — Kenya: +404 cases, +6199 tests since a day ago | 17:03 |
Brainstorm | New from StatNews: How dengue and Zika infections could make people more attractive to mosquitoes: Scientists sent mice on scented chases and swabbed the armpits of people infected with dengue to pinpoint an odor that attracts mosquitoes. → https://www.statnews.com/2022/06/30/dengue-zika-virus-scent-acetophenone/ | 17:10 |
Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Finally we should be glad that G446S in BA.2.75 is not on BA.4/5 background w F486V. Most concerning antigenic variant would have mutation at site 486 plus one at site like 346, 444, or 446 (twitter.com/jbloom_lab/sta…), such as if G446S instead arose on BA.4/5 [... want %more?] → https://twitter.com/jbloom_lab/status/1542526115092123651 | 17:20 |
Brainstorm | New from ClinicalTrials.gov: (news): A Study of SARS-CoV-2 mRNA Vaccine (SYS6006) in Chinese Healthy Participants Aged 18 Years or More → https://clinicaltrials.gov/ct2/show/NCT05439824 | 17:30 |
Brainstorm | New from ClinicalTrials.gov: (news): Incidence, Patient Characteristics and Outcome of Myocarditis After COVID-19 mRNA Vaccine → https://clinicaltrials.gov/ct2/show/NCT05438472 | 17:39 |
Brainstorm | Updates for Netherlands: +6045 cases, +8 deaths since a day ago | 18:05 |
Brainstorm | New from COVID on Twitter: (translated) Tom Wenseleers (@TWenseleers): When opening CovidSafe App made a mistake installing GovApp - CovidSafe App got rid of to make room & GovApp now doesn't give me activation code (Internal Server Error) & so won't install. Does this go hand in hand with the transition from Itsme [... want %more?] → https://twitter.com/TWenseleers/status/1542541315925331968 | 18:18 |
Brainstorm | Updates for Chile: +10896 cases, +12 deaths, +66391 tests since 22 hours ago — Italy: +84234 cases, +59 deaths, +265968 tests since a day ago — Cuba: +34 cases since a day ago — Myanmar: +13 cases since a day ago | 19:02 |
Brainstorm | New from Contagion Live: All-Cause Maternal Mortality Before vs During COVID-19 Pandemic: Maternal mortalities increased 33.3% during the COVID-19 pandemic, while overall deaths increased 22%. Excess deaths were most prevalent in Hispanic and Black mothers. → https://www.contagionlive.com/view/all-cause-maternal-mortality-before-vs-during-covid-19-pandemic | 19:06 |
Brainstorm | New from COVID on Twitter: Luciana Borio, MD (@llborio): Surprising fact in @WhiteHouse announcement: "Over the coming months a combined 1.6 million additional doses [of the safer #monkeypox vaccine] will become available." That's a drop in the bucket. The U.S. needs to rapidly establish domestic manufacturing capacity [... want %more?] → https://twitter.com/llborio/status/1542556717149560838 | 19:55 |
Brainstorm | Updates for Malaysia: +2867 cases, +2 deaths since 23 hours ago — Canada: +2791 cases, +50 deaths since 23 hours ago | 20:04 |
Brainstorm | New from WebMD: Can the Flu Vaccine Help Keep Older Minds Sharp?: Flu vaccination has been linked to a 40% lower risk of Alzheimer’s disease in older adults, according to a new study. → https://www.webmd.com/vaccines/news/20220630/flu-vaccine-older-minds-sharp-study | 20:05 |
Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): What will it take for FDA to end EUA of molnupiravir? FDA approved it at peak Omicron fear (12/22/2022) but turns out prior immunity protects better against severe disease than MOV (>80% vs 30%). Now we're all preimmune, and MOV hasn't been proven to [... want %more?] → https://twitter.com/michaelzlin/status/1542578307517935616 | 20:44 |
-Bridgestorm- ⭕ Earthquake! Lindol! Sismo! Linog! 6.0 Mb tremor, registered by EMSC,HKOEARTHQUAKE5E, with 15 reports, 4 early, occurred 11 minutes ago (18:40:39 UTC), during a crescent moon night, Philippine Islands Region (19.05, 121.19) ± 18 km, ↓3 km likely felt 490 km away (in Tuguegarao, Laoag…) by 795900 people (Twitter) | 20:51 | |
Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): So what will it take for FDA to rescind EUA for a drug with proven risk to make the epidemic worse and no proven benefit? How captured is the FDA that it can with a straight face rule potentially catastrophic risk and potentially zero benefit as a [... want %more?] → https://twitter.com/michaelzlin/status/1542581023011004416 | 20:53 |
-Bridgestorm- 🌒 Earthquake! Lindol! Sismo! Linog! 6.1 Mb tremor, registered by EMSC, with 40 reports, 18 early, occurred 15 minutes ago (18:40:40 UTC), during a crescent moon night, Philippine Islands Region (19.04, 121.32), ↓25 km likely felt 470 km away (Twitter) | 20:55 | |
Brainstorm | Updates for Louisiana, United States: +76753 cases since 12 hours ago | 21:01 |
Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): It seems like almost every day there is another major discovery of broad, neutralizing antibodies to #SARSCoV2 that could be the foundation for pan-β-coronavirus vaccinesYesterdaypnas.org/doi/10.1073/pn…Todayscience.org/doi/10.1126/sc… pic.twitter.com/qANrWz3ybF → https://twitter.com/EricTopol/status/1542582087709913088 | 21:03 |
Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Antibody-laden nasal spray could provide COVID protection — and treatment: Scientists create a hybrid antibody that can sharply cut the amount of SARS-CoV-2 in the lungs of infected mice. → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vog3zb/antibodyladen_nasal_spray_could_provide_covid/ | 21:12 |
Brainstorm | New from WebMD: Pfizer Plans a Vaccine to Target All Coronaviruses: Pizer and its partner BioNTech announced plans on Wednesday to develop a vaccine that will work against SARS-CoV-2 (the virus that causes COVID-19) and the entire class, or family, of related coronaviruses. → https://www.webmd.com/vaccines/covid-19-vaccine/news/20220630/pfizer-plans-vaccine-target-all-coronaviruses | 21:32 |
-Bridgestorm- ⭕ Lindol! Earthquake! 6.2 Mb tremor, registered by GFZ,US, occurred 52 minutes ago (18:40:34 UTC), during a crescent moon night, Namuac, Philippines (18.99, 121.27) ± 6 km, ↓4 km likely felt 320 km away (in Calayan, Claveria, Sanchez Mira, Abulug, Pamplona, Santa Praxedes…) by 139300 people (isc-mirror.iris.washington.edu) | 21:32 | |
Brainstorm | New from NPR Science: Scientists say they've solved a 700-year-old mystery: Where and when Black Death began: For centuries, scientists and historians have wondered where the Black Death — the deadliest pandemic in recorded [... want %more?] → https://www.npr.org/sections/goatsandsoda/2022/06/30/1106858954/scientists-say-theyve-solved-a-700-year-old-mystery-where-and-when-black-death-b | 22:01 |
Brainstorm | Updates for France: +133358 cases since 23 hours ago — Sri Lanka: +13 cases since 23 hours ago | 22:10 |
Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Also @SolidEvidence flags N460K (in BA.2.75) as also in cryptic wastewater lineages twitter.com/SolidEvidence/…In our deep mutational scanning of BA.2 RBD, N460K increases both ACE2 affinity (+0.2 log10 Kd) & RBD expression (a proxy for stability). See [... want %more?] → https://twitter.com/jbloom_lab/status/1542600017055125504 | 22:10 |
Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Living with SARS-CoV-2 means we urgently need to develop smarter surveillance systems to reduce transmission, bc we don't want to be sick all the time. Here they tested wastewater from schools. This could be used to monitor the need for individual testing [... want %more?] → https://twitter.com/GANyborg/status/1542601299157557255 | 22:19 |
Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Impact of "The hiatus of the handshake"science.org/doi/10.1126/sc… @ScienceMagazine @kbratnelson @B_Lopman @EmoryRollins @EmoryEPI A thoughtful essay on what we've learned from the pandemic, the rippling effects on other infectious diseases spread, & optimizing [... want %more?] → https://twitter.com/EricTopol/status/1542605368940892160 | 22:30 |
roosterphant | hey is there any info already on mortality of ba.4/ba.5 vs the original omicron? | 22:46 |
de-facto | hard to estimate as immunological history is a time dependent function of the past | 22:50 |
de-facto | but since BA.4/5 is taking over BA.1/2 wave also with reinfections and case numbers are rising it means its significantly more able to spread, hence will have increasing impact on populations, also in terms of fatal outcomes | 22:51 |
de-facto | maybe its just a limited wave though as from observing e.g. Portugal | 22:52 |
de-facto | we probably will know end of July for most EU countries | 22:53 |
Brainstorm | New from CIDRAP: Real-world study of Pfizer vaccine in kids finds moderate Omicron protection: Lisa Schnirring | News Editor | CIDRAP News Jun 30, 2022 Findings were similar to adults, but testing policy changes limited the study's ability to assess [... want %more?] → https://www.cidrap.umn.edu/news-perspective/2022/06/real-world-study-pfizer-vaccine-kids-finds-moderate-omicron-protection | 22:59 |
roosterphant | id guess its a real wave since its come here to croatia | 23:24 |
roosterphant | cases have doubled in the last week | 23:24 |
roosterphant | im just wondering how was the CFR in countries that got it before us | 23:24 |
de-facto | i guess around the same as Omicron BA.2 maybe slightly more due to shared mutations with Delta https://covariants.org/shared-mutations | 23:30 |
de-facto | e.g. S:L452R | 23:31 |
roosterphant | uh hope it doesnt spread as much as omicron did, then | 23:32 |
de-facto | also it got the S-gene target failure del 69 70 | 23:32 |
de-facto | e.g. same as alpha | 23:32 |
roosterphant | i think i caught omicron, i managed to dodge everything else | 23:32 |
de-facto | you tested positive? | 23:32 |
roosterphant | no but 2 people around me did and i had the exact same symptoms (hence "think") | 23:33 |
de-facto | hmm makes sense Omicron is extremely infectious | 23:34 |
de-facto | stay isolated then for 10-14 days | 23:34 |
de-facto | what are your symptoms? | 23:34 |
roosterphant | oh not now :D that was in february or so | 23:35 |
roosterphant | i just did half dozen rapid tests, shouldve done a PCR but in the end was afraid to go there | 23:35 |
de-facto | ah well you could get a test for antibodies against the viral N-protein (as the mRNA vaccines only contain s-protein) | 23:35 |
roosterphant | i saw how it was carried out and figured i would probably catch it there if i didnt have it already | 23:36 |
de-facto | huh? why? | 23:36 |
de-facto | i got several PCR tests and never got infected | 23:36 |
roosterphant | people sneeze in a tent, then other people come sneeze in the same tent etc. | 23:36 |
roosterphant | like 3 min time difference | 23:36 |
roosterphant | <de-facto> ah well you could get a test for antibodies against the viral N-protein (as the mRNA vaccines only contain s-protein) | 23:37 |
roosterphant | thats interesting, didnt know that :) i got some kind of a test later but they said they couldnt rule out if it just detected the vaccine | 23:37 |
de-facto | oh hmm i had to wait outdoors then they called one after the other indoors for taking the sample | 23:37 |
de-facto | well there are the inactivated vaccines (containing whole virions that were inactivated with beta-propiolactone to make them replication incompetent) which also would contain N-protein (hence induce antibodies against that too) | 23:38 |
de-facto | e.g. the chinese Sinovac for example | 23:39 |
roosterphant | i had j&j fwiw | 23:39 |
de-facto | but those were not so common in EU, hence you most likely got mRNA (BioNTech, Pfizer, Moderna) or Adenovirus (AstraZeneca, Sputnik V) vector vaccine that would instruct cells to produce the S-protein of the very first isolate (Wuhan-Hu-1) hence only induce antibodies against S-protein | 23:40 |
de-facto | yeah JnJ also in Adenovirus vector that instructs cells to produce Wuhan-Hu-1 S-protein | 23:41 |
de-facto | so if your body produced antibodies against the N-protein it would have had seen it from the real full pathogen | 23:41 |
de-facto | (N meaning nucleocapsid the protein around which the viral RNA wraps inside the virions) | 23:41 |
de-facto | (S meaning spike those little docking hands the virions use to intrude into cells) | 23:42 |
de-facto | antibodies decay with time exponentially though, hence only a for limited amount of time its possible to trigger such antibody tests thresholds for blood samples | 23:43 |
de-facto | afaik after vaccination antibody levels would half every 50-70 days or such | 23:43 |
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