libera/##covid-19/ Thursday, 2022-06-30

BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Meanwhile Pfizer's standard NDA of Paxlovid should be sent back because it's entirely based on unvaxxed pre-Omicron resultspfizer.com/news/press-rel… → https://twitter.com/michaelzlin/status/154226744465112678400:08
de-facto%title https://arstechnica.com/science/2022/06/fauci-reports-covid-rebound-says-its-much-worse-than-initial-illness/00:08
Brainstormde-facto: From arstechnica.com: Fauci reports COVID rebound, says his is “much worse” than initial illness | Ars Technica00:09
LjLde-facto, uhm i hope this paxlovid rebound phenomenon isn't more common than it seemed00:34
LjLand that having worse disease also isn't00:34
LjLit's such a promising drug00:34
de-factowell every drug will only have limited effectivity as it puts selection pressure on the pathogen00:39
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A  new systematic review on long distance (>2 meters, 6.6 ft) airborne transmission: the importance of adequate ventilation to prevent Covid for indoor venuesbmj.com/content/377/bm… @bmj_latest by @daph_duval and colleagues#COVIDisAirborne pic.twitter.com/4r4ifSYLll → https://twitter.com/EricTopol/status/154227446110117888100:39
de-factoit can work for some time, but the more its used the less effective its going to become00:39
de-factoyes its a promising drug, but no single drug will solve the covid problem00:42
de-factoit can help to some extend only00:42
BrainstormUpdates for Brazil: +75797 cases, +225 deaths since 23 hours ago — Guatemala: +4342 cases, +19 deaths since 23 hours ago — Bahrain: +2008 cases, +7099 tests since 23 hours ago — Lebanon: +1399 cases, +1 deaths since a day ago01:03
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): SARSCoV2 can mutate a lot and remain functional. That's how we got Omicron to be so diverged immunologically from Wuhan, almost as diverged as SARSCoV1. That happens even without MOV, but MOV has little/no clinical benefit, and now we see harm in action. → https://twitter.com/michaelzlin/status/154228336705958297601:10
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Plus there *is* evidence SARSCoV2 mutants are selected for survival during MOV treatment in the host. In Merck's ECCMID poster, we see mutations are enriched in spike and higher than placebo. Thus selection occurs (e.g. for entry or immunoevasion) [... want %more?] → https://twitter.com/michaelzlin/status/154228593341165158401:20
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Extrapolating outcomes from S Africa to other countries is difficult b/o marked differences in multiple demographics, such as age, % prior infections. But what has largely been missed is the impact of mass Beta variant exposure, the strain w/ most immune escape [... want %more?] → https://twitter.com/EricTopol/status/154228817160125235401:30
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Detailed outbreak transmission assessment of all of these 18 reports in the following settings:restaurants, singing events, department store, courtroom, abatement block, quarantine hotel, bus, meat processing plant, office pic.twitter.com/eclb3AMKdl → https://twitter.com/EricTopol/status/154228976176254976201:41
BrainstormUpdates for Isle of Man: +2642 cases since 8 days ago — Guyana: +104 cases, +2 deaths since 21 hours ago — Canada: +2612 cases, +23 deaths since 22 hours ago02:00
LjL%print https://twitter.com/EricTopol/status/154215318882813542602:18
BrainstormLjL, It says: Eric Topol on Twitter: "Yesterday we learned Tony Fauci had Paxlovid rebound, a common problem, and is taking a 2nd Rx course. He'll do well. But today we learn about 11 naturally occurring mutations of Mpro, the target of Paxlovid, which could confer resistance in the future https://t.co/mDfZsIC9dw https://t.co/3cG55VSuHY" / Twitter02:18
de-facto%title https://www.biorxiv.org/content/10.1101/2022.06.28.497978v102:23
Brainstormde-facto: From www.biorxiv.org: Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir | bioRxiv02:23
BrainstormUpdates for Norway: +740 cases since 22 hours ago — Slovakia: +676 cases since 14 hours ago — France: +148 cases since 5 hours ago03:02
BrainstormNew from r/COVID19: COVID19: Seasonal coronaviruses and SARS-CoV-2: effects of preexisting immunity during the COVID-19 pandemic → https://old.reddit.com/r/COVID19/comments/vnvfu6/seasonal_coronaviruses_and_sarscov2_effects_of/03:43
BrainstormUpdates for Australia: +49079 cases, +89 deaths since 23 hours ago — Albania: +581 cases since 13 hours ago — San Marino: +194 cases since 2 days ago03:59
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Triple vaccination seems to reduce the chance of long COVID – but we still need to prepare for a jump in cases → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vnxg2z/triple_vaccination_seems_to_reduce_the_chance_of/04:44
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: "higher markers of inflammation in the cerebral spinal fluid, but in some people, we're also seeing markers of vascular dysregulation, or that the blood cells within the brain compartment aren't acting and behaving normally" → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vnxlk8/higher_markers_of_inflammation_in_the_cerebral/04:54
BrainstormUpdates for Kazakhstan: +140 cases since 18 hours ago05:01
BrainstormUpdates for Germany: +132671 cases, +83 deaths since 23 hours ago — Mexico: +23148 cases, +31 deaths, +38115 tests since a day ago — Thailand: +2695 cases, +14 deaths since a day ago06:10
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Unfortunate timing on that headline from 2 days ago Coming down with bad rebound COVID-19 after taking 4 vaccine doses and Paxlovid definitely doesn't sound like a waning pandemicI just happened to notice it and thought it was an old story but [... want %more?] → https://twitter.com/michaelzlin/status/154235952769717862506:20
BrainstormUpdates for Bolivia: +1573 cases since 22 hours ago — Pakistan: +641 cases, +18813 tests since 22 hours ago — Venezuela: +195 cases, +2 deaths since 2 days ago07:07
BrainstormUpdates for Lombardy, Italy: +25132 cases, +9 deaths since a day ago — Georgia, United States: +20971 cases, +132 deaths since 7 days ago — Victoria, Australia: +20509 cases, +40 deaths since 2 days ago — Bavaria, Germany: +20360 cases, +14 deaths since a day ago08:10
BrainstormNew from r/Coronavirus: Daily Discussion Thread | June 30, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/vo20gi/daily_discussion_thread_june_30_2022/09:02
BrainstormNew from Science-Based Medicine: Moral outrage is not a good guide to pandemic policy reform. Vinay Prasad, please take note.: Vinay Prasad identifies some dubious problems in the government's efforts to protect public health, and offers some [... want %more?] → https://sciencebasedmedicine.org/moral-outrage-is-not-a-good-guide-to-pandemic-policy-reform-vinay-prasad-please-take-note/09:50
BrainstormNew from EMA: What's new: Orphan: Orphan designation: Recombinant human monoclonal antibody to insulin receptor, Treatment of congenital hyperinsulinism, 14/07/2016, Positive → https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-16-170210:29
BrainstormNew from BMJ: Seven days in medicine: 22-28 June 2022: AbortionUS Supreme Court ends constitutional right to abortionDoctors condemned the US Supreme Court’s 24 June ruling to overturn the 1973 Roe v Wade decision, thus ending women’s 50 year old constitutional right to abortion and leaving the issue for individual states [... want %more?] → http://www.bmj.com/content/377/bmj.o1574.short10:49
BrainstormUpdates for Japan: +12369 cases, +3 deaths, +146957 tests since 14 hours ago — Israel: +6093 cases since 14 hours ago — Kerala, India: +4459 cases, +17 deaths since a day ago — Karnataka, India: +1945 cases, +2 deaths since a day ago11:05
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): This systematic review found evidence of long distance airborne transmission of SARS-CoV-2 & found that insufficient air replacement probably contributed to transmission.The results demonstrate the importance of adequate ventilation & other mitigation [... want %more?] → https://twitter.com/GANyborg/status/154243577596239053011:18
BrainstormNew from BMJ: Trust in vaccines . . . and other stories: Improving vaccine uptakeA survey of doctors in the Czech Republic finds, not surprisingly, that they have a high degree of trust in vaccines against covid-19. This is at odds with the results of a... → http://www.bmj.com/content/377/bmj.o1532.short11:46
BrainstormNew from COVID on Twitter: (translated) Gunhild Alvik Nyborg (@GANyborg): Does no one see what is going on? A large proportion of the population has recently undergone at least one COVID infection. This causes cognitive problems in many and increased risk of stroke, arrhythmias and dizziness    @tryggtrafikk nrk.no/dokumentar/xl/… → https://twitter.com/GANyborg/status/154244562686414848011:56
BrainstormUpdates for Russia: +3106 cases, +56 deaths since 23 hours ago — Afghanistan: +125 cases, +1 deaths, +1035 tests since 23 hours ago12:02
BrainstormNew from ScienceNews: New COVID-19 boosters could contain bits of the omicron variant: The omicron variant is different enough from the original version to require an update to COVID-19 vaccines, experts say. → https://www.sciencenews.org/article/covid-vaccine-booster-omicron-variant-coronavirus12:06
BrainstormNew from COVID on Twitter: (translated) Gunhild Alvik Nyborg (@GANyborg): @tryggtrafikk It is now established knowledge that very many (most studies find about 1/3 in the studies that are available so far) are affected by cognitive functions after COVID. Norway must soon wake up: SARS-CoV-2 attacks the brain. [... want %more?] → https://twitter.com/GANyborg/status/154245204547886284812:26
BrainstormNew from COVID on Twitter: (translated) Gunhild Alvik Nyborg (@GANyborg): @tryggtrafikk And here you will find an accumulation of substances in COVID that are very toxic to nerve cells, of the same type as in neurodegenerative diseases such as Alzheimer's and Parkinson's.nature.com/articles/s4146… → https://twitter.com/GANyborg/status/154245395590873907312:35
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): @tryggtrafikk En til. Jeg driver ikke cherry-picking. Søvnvansker er vanlig, obs v bilkjøring! "The covid-19 group also showed an increased risk of incident neurocognitive decline and sleep disorders.... The risk of any incident mental health diagnosis... [... want %more?] → https://twitter.com/GANyborg/status/154245959499526963312:55
BrainstormUpdates for UAE: +1778 cases, +1 deaths, +288743 tests since 22 hours ago — Iran: +529 cases, +3 deaths since 21 hours ago14:01
BrainstormNew from r/COVID19: COVID19: COVID-19 cases rising in 110 countries, warns WHO → https://old.reddit.com/r/COVID19/comments/vo6lqx/covid19_cases_rising_in_110_countries_warns_who/14:03
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 30JUN22 → https://old.reddit.com/r/nCoV/comments/vo6udl/global_covid_cases_for_30jun22/14:13
BrainstormNew from r/Coronavirus: Coronavirus: COVID-19 boosters recommended for the fall, Canada's vaccine advisory body says → https://old.reddit.com/r/Coronavirus/comments/vo794h/covid19_boosters_recommended_for_the_fall_canadas/14:52
BrainstormUpdates for Hong Kong: +2358 cases, +2 deaths since 22 hours ago — Indonesia: +2248 cases, +6 deaths, +79384 tests since a day ago — Bangladesh: +2187 cases, +13905 tests since 22 hours ago — Croatia: +1148 cases, +5 deaths, +3532 tests since a day ago15:04
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: Pfizer and U.S. strike $3.2 billion deal for Covid vaccine; marketing of morning-after pills shifts to mail-order options → https://www.statnews.com/pharmalot/2022/06/30/covid19-vaccines-pfizer-contraception-insulin-lilly-novartis-opioids-walmart/15:31
BrainstormNew from COVID on Twitter: Tom Peacock (@PeacockFlu): Spike mutation-wise its got normal BA.2 mutations + K147E, W152R, F157L, I210V, G257S, G339H, G446S, N460K and reversion of R493Q - none of these individually really flag as that worrying but all appearing together at once is another matter... → https://twitter.com/PeacockFlu/status/154250222850576793715:42
BrainstormNew from COVID on Twitter: Tom Peacock (@PeacockFlu): worth saying its entirely possible this is just growing against a background of BA.2(.12.1) and that it hits the encroaching wall of BA.5 and stalls out... we will see → https://twitter.com/PeacockFlu/status/154250652271382937716:02
BrainstormUpdates for Philippines: +1307 cases, +13 deaths, +24154 tests since a day ago16:06
BrainstormNew from FDA Press Releases: Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses: The FDA has advised manufacturers seeking to update their COVID-19 [... want %more?] → http://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster16:21
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Antivaxx MAGA preacher says if he's elected to the U.S. Senate, he's going to have Fauci convicted of crimes against humanity: "Fauci is one of the greatest mass murderers in human history, worse than Hitler and Stalin!" → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vo9n57/antivaxx_maga_preacher_says_if_hes_elected_to_the/16:31
BrainstormNew from r/COVID19: COVID19: Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial → https://old.reddit.com/r/COVID19/comments/vo9ymw/enoxaparin_for_primary_thromboprophylaxis_in/16:41
BrainstormNew from r/COVID19: COVID19: Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses → https://old.reddit.com/r/COVID19/comments/voa3l3/coronavirus_covid19_update_fda_recommends/16:51
BrainstormUpdates for Singapore: +9505 cases since 19 hours ago — Iraq: +2769 cases, +2 deaths since a day ago — Serbia: +921 cases, +1 deaths, +7441 tests since 22 hours ago — Kenya: +404 cases, +6199 tests since a day ago17:03
BrainstormNew from StatNews: How dengue and Zika infections could make people more attractive to mosquitoes: Scientists sent mice on scented chases and swabbed the armpits of people infected with dengue to pinpoint an odor that attracts mosquitoes. → https://www.statnews.com/2022/06/30/dengue-zika-virus-scent-acetophenone/17:10
BrainstormNew from COVID on Twitter: Bloom Lab (@jbloom_lab): Finally we should be glad that G446S in BA.2.75 is not on BA.4/5 background w F486V. Most concerning antigenic variant would have mutation at site 486 plus one at site like 346, 444, or 446 (twitter.com/jbloom_lab/sta…), such as if G446S instead arose on BA.4/5 [... want %more?] → https://twitter.com/jbloom_lab/status/154252611509212365117:20
BrainstormNew from ClinicalTrials.gov: (news): A Study of SARS-CoV-2 mRNA Vaccine (SYS6006) in Chinese Healthy Participants Aged 18 Years or More → https://clinicaltrials.gov/ct2/show/NCT0543982417:30
BrainstormNew from ClinicalTrials.gov: (news): Incidence, Patient Characteristics and Outcome of Myocarditis After COVID-19 mRNA Vaccine → https://clinicaltrials.gov/ct2/show/NCT0543847217:39
BrainstormUpdates for Netherlands: +6045 cases, +8 deaths since a day ago18:05
BrainstormNew from COVID on Twitter: (translated) Tom Wenseleers (@TWenseleers): When opening CovidSafe App made a mistake installing GovApp - CovidSafe App got rid of to make room & GovApp now doesn't give me activation code (Internal Server Error) & so won't install. Does this go hand in hand with the transition from Itsme [... want %more?] → https://twitter.com/TWenseleers/status/154254131592533196818:18
BrainstormUpdates for Chile: +10896 cases, +12 deaths, +66391 tests since 22 hours ago — Italy: +84234 cases, +59 deaths, +265968 tests since a day ago — Cuba: +34 cases since a day ago — Myanmar: +13 cases since a day ago19:02
BrainstormNew from Contagion Live: All-Cause Maternal Mortality Before vs During COVID-19 Pandemic: Maternal mortalities increased 33.3% during the COVID-19 pandemic, while overall deaths increased 22%. Excess deaths were most prevalent in Hispanic and Black mothers. → https://www.contagionlive.com/view/all-cause-maternal-mortality-before-vs-during-covid-19-pandemic19:06
BrainstormNew from COVID on Twitter: Luciana Borio, MD (@llborio): Surprising fact in @WhiteHouse announcement: "Over the coming months a combined 1.6 million additional doses [of the safer #monkeypox vaccine] will become available." That's a drop in the bucket. The U.S. needs to rapidly establish domestic manufacturing capacity [... want %more?] → https://twitter.com/llborio/status/154255671714956083819:55
BrainstormUpdates for Malaysia: +2867 cases, +2 deaths since 23 hours ago — Canada: +2791 cases, +50 deaths since 23 hours ago20:04
BrainstormNew from WebMD: Can the Flu Vaccine Help Keep Older Minds Sharp?: Flu vaccination has been linked to a 40% lower risk of Alzheimer’s disease in older adults, according to a new study. → https://www.webmd.com/vaccines/news/20220630/flu-vaccine-older-minds-sharp-study20:05
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): What will it take for FDA to end EUA of molnupiravir? FDA approved it at peak Omicron fear (12/22/2022) but turns out prior immunity protects better against severe disease than MOV (>80% vs 30%). Now we're all preimmune, and MOV hasn't been proven to [... want %more?] → https://twitter.com/michaelzlin/status/154257830751793561620:44
-Bridgestorm- ⭕ Earthquake! Lindol! Sismo! Linog! 6.0 Mb tremor, registered by EMSC,HKOEARTHQUAKE5E, with 15 reports, 4 early, occurred 11 minutes ago (18:40:39 UTC), during a crescent moon night, Philippine Islands Region (19.05, 121.19) ± 18 km, ↓3 km likely felt 490 km away (in Tuguegarao, Laoag…) by 795900 people (Twitter)20:51
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): So what will it take for FDA to rescind EUA for a drug with proven risk to make the epidemic worse and no proven benefit? How captured is the FDA that it can with a straight face rule potentially catastrophic risk and potentially zero benefit as a [... want %more?] → https://twitter.com/michaelzlin/status/154258102301100441620:53
-Bridgestorm- 🌒 Earthquake! Lindol! Sismo! Linog! 6.1 Mb tremor, registered by EMSC, with 40 reports, 18 early, occurred 15 minutes ago (18:40:40 UTC), during a crescent moon night, Philippine Islands Region (19.04, 121.32), ↓25 km likely felt 470 km away (Twitter)20:55
BrainstormUpdates for Louisiana, United States: +76753 cases since 12 hours ago21:01
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): It seems like almost every day there is another major discovery of broad, neutralizing antibodies to #SARSCoV2 that could be the foundation for pan-β-coronavirus vaccinesYesterdaypnas.org/doi/10.1073/pn…Todayscience.org/doi/10.1126/sc… pic.twitter.com/qANrWz3ybF → https://twitter.com/EricTopol/status/154258208770991308821:03
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Antibody-laden nasal spray could provide COVID protection — and treatment: Scientists create a hybrid antibody that can sharply cut the amount of SARS-CoV-2 in the lungs of infected mice. → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vog3zb/antibodyladen_nasal_spray_could_provide_covid/21:12
BrainstormNew from WebMD: Pfizer Plans a Vaccine to Target All Coronaviruses: Pizer and its partner BioNTech announced plans on Wednesday to develop a vaccine that will work against SARS-CoV-2 (the virus that causes COVID-19) and the entire class, or family, of related coronaviruses. → https://www.webmd.com/vaccines/covid-19-vaccine/news/20220630/pfizer-plans-vaccine-target-all-coronaviruses21:32
-Bridgestorm- ⭕ Lindol! Earthquake! 6.2 Mb tremor, registered by GFZ,US, occurred 52 minutes ago (18:40:34 UTC), during a crescent moon night, Namuac, Philippines (18.99, 121.27) ± 6 km, ↓4 km likely felt 320 km away (in Calayan, Claveria, Sanchez Mira, Abulug, Pamplona, Santa Praxedes…) by 139300 people (isc-mirror.iris.washington.edu)21:32
BrainstormNew from NPR Science: Scientists say they've solved a 700-year-old mystery: Where and when Black Death began: For centuries, scientists and historians have wondered where the Black Death — the deadliest pandemic in recorded [... want %more?] → https://www.npr.org/sections/goatsandsoda/2022/06/30/1106858954/scientists-say-theyve-solved-a-700-year-old-mystery-where-and-when-black-death-b22:01
BrainstormUpdates for France: +133358 cases since 23 hours ago — Sri Lanka: +13 cases since 23 hours ago22:10
BrainstormNew from COVID on Twitter: Bloom Lab (@jbloom_lab): Also @SolidEvidence flags N460K (in BA.2.75) as also in cryptic wastewater lineages twitter.com/SolidEvidence/…In our deep mutational scanning of BA.2 RBD, N460K increases both ACE2 affinity (+0.2 log10 Kd) & RBD expression (a proxy for stability). See [... want %more?] → https://twitter.com/jbloom_lab/status/154260001705512550422:10
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Living with SARS-CoV-2 means we urgently need to develop smarter surveillance systems to reduce transmission, bc we don't want to be sick all the time. Here they tested wastewater from schools. This could be used to monitor the need for individual testing [... want %more?] → https://twitter.com/GANyborg/status/154260129915755725522:19
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Impact of "The hiatus of the handshake"science.org/doi/10.1126/sc… @ScienceMagazine @kbratnelson @B_Lopman @EmoryRollins @EmoryEPI A thoughtful essay on what we've learned from the pandemic, the rippling effects on other infectious diseases spread, & optimizing [... want %more?] → https://twitter.com/EricTopol/status/154260536894089216022:30
roosterphanthey is there any info already on mortality of ba.4/ba.5 vs the original omicron?22:46
de-factohard to estimate as immunological history is a time dependent function of the past22:50
de-factobut since BA.4/5 is taking over BA.1/2 wave also with reinfections and case numbers are rising it means its significantly more able to spread, hence will have increasing impact on populations, also in terms of fatal outcomes22:51
de-factomaybe its just a limited wave though as from observing e.g. Portugal22:52
de-factowe probably will know end of July for most EU countries22:53
BrainstormNew from CIDRAP: Real-world study of Pfizer vaccine in kids finds moderate Omicron protection: Lisa Schnirring | News Editor | CIDRAP News Jun 30, 2022 Findings were similar to adults, but testing policy changes limited the study's ability to assess [... want %more?] → https://www.cidrap.umn.edu/news-perspective/2022/06/real-world-study-pfizer-vaccine-kids-finds-moderate-omicron-protection22:59
roosterphantid guess its a real wave since its come here to croatia23:24
roosterphantcases have doubled in the last week23:24
roosterphantim just wondering how was the CFR in countries that got it before us23:24
de-factoi guess around the same as Omicron BA.2 maybe slightly more due to shared mutations with Delta https://covariants.org/shared-mutations23:30
de-factoe.g. S:L452R23:31
roosterphantuh hope it doesnt spread as much as omicron did, then23:32
de-factoalso it got the S-gene target failure del 69 7023:32
de-factoe.g. same as alpha23:32
roosterphanti think i caught omicron, i managed to dodge everything else23:32
de-factoyou tested positive?23:32
roosterphantno but 2 people around me did and i had the exact same symptoms (hence "think")23:33
de-factohmm makes sense Omicron is extremely infectious23:34
de-factostay isolated then for 10-14 days23:34
de-factowhat are your symptoms?23:34
roosterphantoh not now :D that was in february or so23:35
roosterphanti just did half dozen rapid tests, shouldve done a PCR but in the end was afraid to go there23:35
de-factoah well you could get a test for antibodies against the viral N-protein (as the mRNA vaccines only contain s-protein)23:35
roosterphanti saw how it was carried out and figured i would probably catch it there if i didnt have it already23:36
de-factohuh? why?23:36
de-factoi got several PCR tests and never got infected23:36
roosterphantpeople sneeze in a tent, then other people come sneeze in the same tent etc.23:36
roosterphantlike 3 min time difference23:36
roosterphant<de-facto> ah well you could get a test for antibodies against the viral N-protein (as the mRNA vaccines only contain s-protein)23:37
roosterphantthats interesting, didnt know that :) i got some kind of a test later but they said they couldnt rule out if it just detected the vaccine23:37
de-factooh hmm i had to wait outdoors then they called one after the other indoors for taking the sample23:37
de-factowell there are the inactivated vaccines (containing whole virions that were inactivated with  beta-propiolactone  to make them replication incompetent) which also would contain N-protein (hence induce antibodies against that too)23:38
de-factoe.g. the chinese Sinovac for example23:39
roosterphanti had j&j fwiw23:39
de-factobut those were not so common in EU, hence you most likely got mRNA (BioNTech, Pfizer, Moderna) or Adenovirus (AstraZeneca, Sputnik V)  vector vaccine that would instruct cells to produce the S-protein of the very first isolate (Wuhan-Hu-1) hence only induce antibodies against S-protein23:40
de-factoyeah JnJ also in Adenovirus vector that instructs cells to produce Wuhan-Hu-1 S-protein23:41
de-factoso if your body produced antibodies against the N-protein it would have had seen it from the real full pathogen23:41
de-facto(N meaning nucleocapsid the protein around which the viral RNA wraps inside the virions)23:41
de-facto(S meaning spike those little docking hands the virions use to intrude into cells)23:42
de-factoantibodies decay with time exponentially though, hence only a for limited amount of time its possible to trigger such antibody tests thresholds for blood samples23:43
de-factoafaik after vaccination antibody levels would half every 50-70 days or such23:43

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