libera/##covid-19/ Friday, 2022-07-08

BrainstormUpdates for Guatemala: +5786 cases, +18 deaths since a day ago — Monaco: +91 cases since a day ago00:04
Timvde"Protection against severe reinfection remains very strong" <- And that is probably skewing our numbers quite badly atm, feeding the antivaxxers :)00:07
BrainstormNew from r/Science: science: New Study Finds People Who Practice Intermittent Fasting Experience Less Severe Complications from COVID-19 → https://old.reddit.com/r/science/comments/vttqpi/new_study_finds_people_who_practice_intermittent/00:08
TimvdeLooking at the raw numbers in Belgium, we are seeing only a relatively small difference in numbers, including severe illness and death, between unvaccinated, double vaccinated and boosted00:09
TimvdeBut the unvaccinated are by now also protected, by previous infection00:09
de-factoOne problem seems to be that infection from BA.2 does not (or only too weakly) protect against a reinfection with BA.500:12
TimvdeAgainst reinfection, yes. But (according to the tweet) it protects against severe illness, which is more important.00:12
de-factowhich makes sense, if a certain type of immunity is quite prevalent in a population it is a common factor for selection bias of mutations, hence will pressure the antigenic drift towards evading that very widespread type of immunity00:13
de-factoamong others there are two quite important aspects of the immune system preparing for future contamination with a mutant of a pathogen that it already has seen00:14
de-factofirst aspect would be that the immune system prepares a library of B-cells producing antibodies against a certain variant of the antigen (e.g. S-protein etc) that are highly specific to stick to virions surface characteristics that are similar enough to the previous (known) version00:15
de-factothis largely contributes to the protection against (re)infection, but is highly specific to a certian variant (hence also can be evaded by antigenic drift more easily than the second aspect)00:16
de-factothe second aspect would be the cellular immunity, e.g. T-cells that are trained to react to smaller (broken up) parts of the antigen and protecting against severe progressions (e.g. by killing off cells that are in the process of producing more virions etc)00:18
de-factosince those T-cells remember smaller parts of the antigen their target spectrum is much broader in terms of inclusion of (future) variants, hence evading this aspect of immunity is much harder for a pathogen00:19
TimvdeYes, that's how I also understood it :)00:20
de-factoessentially this means that evasion mainly occurs from B-cells antibodies (hence reinfections are quite likely) but severe progressions are much rarer once T-cells are trained (with a much broader target group of small antigen fragments presenting in almost all mutants)00:20
de-factoof course in reality its much more complicated than that, but that is one valid birds eye perspective as far as i understood it00:21
TimvdeIt's also much more important for the pathogen to evade B-cells than T-cells, because that's how it spreads. It doesn't gain or lose from making the patient more sick. So any change there is more left to chance than an actual evolutionary benefit.00:23
de-factoyes exactly, the pathogen measures its "success" in terms or reproducing itself in a population of potential hosts00:24
TimvdeBut it also means that when people say "viruses evolve to become less dangerous", they are actually wrong...00:27
TimvdeWhich is of course bad news, it would be nice if they did :P00:27
de-factowell it all depends on the average moment of transmission to the next host00:28
TimvdeI mean, there is a threshold of course, if you immediately start spitting out blood, people will notice and be less likely to spread it00:28
TimvdeI suppose viruses may evolve towards a longer incubation period?00:28
de-factoonly properties of the pathogen that have impact on the timespan between contamination and transmission to the next host actually play a role for the reproduction in a population, because usually sick dont have nearly as many contacts as unaware spreaders00:29
TimvdeBut there's probably a limit on how long you can be infectious without having symptoms, while still efficiently replicating00:29
de-factosymptoms usually come from the immune systems reaction, not so much from the virus itself00:30
de-factoat least not at the start of the infection00:30
de-facto(maybe later on damage will become obvious, e.g. when cells start to fuse their membranes etc)00:31
TimvdeSo that's just immune evasion again00:31
de-factothe longer the pathogen can replicate on cellular level without the immune system becoming aware of it (and thereby starting to cause symptoms) the higher the viral load can become in an unaware spreader infecting other susceptibe in a population00:32
de-factobut the immune system learns, e.g. it will now become aware of the pathogen presence sooner for reinfections00:33
de-factoe.g. it may be common that people start to notice symptoms prior to their test results coming back positive (at least in theory)00:34
TimvdeBed time here, good night :)00:43
BrainstormNew from The Lancet (Online): [Health Policy] International law reform for One Health notifications: Epidemic risk assessment and response relies on rapid information sharing. Using examples from the past decade, we discuss the limitations of the present system for outbreak notifications, [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00942-4/fulltext01:00
BrainstormUpdates for Brazil: +72050 cases, +244 deaths since 21 hours ago — Montenegro: +483 cases, +1748 tests since a day ago — Rwanda: +70 cases since 19 hours ago01:00
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceA first model that captures some longcovid features. science.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/154518814436596531201:39
BrainstormUpdates for South Korea: +19310 cases, +12 deaths since 23 hours ago — Bulgaria: +842 cases, +1 deaths since 23 hours ago02:02
BrainstormUpdates for Channel Islands: +1584 cases since 2 days ago — Norway: +472 cases since 23 hours ago — Syria: +5 cases since a day ago02:59
BrainstormNew from COVID on Twitter: Josiah Grindrod is usually self limiting (@JT_Grindrod): Read this while keeping in mind the people that told you Omicron is "mild"They pitched it as a "natural booster" that would "end the pandemic"6 months of hell from a "mild" case. And we're no closer to ending the pandemic than [... want %more?] → https://twitter.com/JT_Grindrod/status/154521001142871654503:04
BrainstormUpdates for Colombia: +23667 cases, +132 deaths since 7 days ago — Australia: +41973 cases, +41 deaths since 23 hours ago — French Guiana: +1417 cases, +1 deaths since 6 days ago — Saint Lucia: +71 cases since 2 days ago04:02
BrainstormNew from COVID on Twitter: SARS News Network (SNN)     (@COVIDnewsfast): I realize that I said I was only rebranding to the SNN title for June to bring awareness back to this pandemic, however I believe it has grown on me quite a bit, and have decided to keep it as the new permanent name for the feed. Just to be [... want %more?] → https://twitter.com/COVIDnewsfast/status/154523703688956313604:50
BrainstormUpdates for Mexico: +32295 cases, +48 deaths, +49212 tests since 23 hours ago05:04
de-facto%title https://www.nature.com/articles/s41586-022-05049-606:01
Brainstormde-facto: From www.nature.com: Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission | Nature06:01
BrainstormUpdates for Bolivia: +2910 cases since 23 hours ago — Germany: +117732 cases, +131 deaths since a day ago06:07
BrainstormNew from Virological.org: Latest topics: First Monkeypox virus sequence from northern Mexico:  Kame A. Galán-Huerta 1, Manuel Paz-Infanzon 2, Laura Nuzzolo-Shihadeh 2, Alí F. Ruiz-Higareda 1, Paola Bocanegra-Ibarias 2, Daniel Zacarias-Villarea l3, Luis A. Yamallel-Ortega 3, Maria D. [... want %more?] → https://virological.org/t/first-monkeypox-virus-sequence-from-northern-mexico/88206:45
BrainstormUpdates for Belgium: +29584 cases, +25 deaths since 3 days ago — Peru: +6106 cases, +11 deaths, +46044 tests since a day ago07:03
BrainstormNew from COVID on Twitter: Balazs Lab (@BalazsLab): Our preprint is live! We find that IgG antibody subclass has a big influence on protective efficacy of VRC07 broadly neutralizing antibody against vaginal HIV transmission in humanized mice. We also show that even a little VRC07 yields protection in [... want %more?] → https://twitter.com/BalazsLab/status/154527937509192908807:42
BrainstormUpdates for Bavaria, Germany: +21178 cases, +32 deaths since a day ago — Ohio, United States: +18838 cases, +68 deaths since 6 days ago — New South Wales, Australia: +12710 cases, +7 deaths since a day ago — Bogota, Colombia: +8846 cases, +36 deaths since 6 days ago08:00
BrainstormNew from r/COVID19: COVID19: The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients-A Large Population-Based Study → https://old.reddit.com/r/COVID19/comments/vu3nqi/the_incidence_of_myocarditis_and_pericarditis_in/08:11
BrainstormNew from MedicineNet: (news): FDA Allows Pharmacists to Prescribe COVID Drug Paxlovid → http://www.medicinenet.com/script/main/art.asp08:40
BrainstormUpdates for Uzbekistan: +91 cases since 23 hours ago09:03
BrainstormNew from r/Coronavirus: Daily Discussion Thread | July 08, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/vu4kos/daily_discussion_thread_july_08_2022/09:08
BrainstormNew from COVID on Twitter: Florian Krammer (@florian_krammer): Please consider joining the 16th Vaccine Congress at Lake Garda in Italy in September! Here is the registration link. I just secured @TheBcellArtist as speaker and many other great speakers will be joining! elsevier.com/events/confere… pic.twitter.com/2wya381cYg → https://twitter.com/florian_krammer/status/154531643565160038410:05
BrainstormNew from r/COVID19: COVID19: Is 5 Days of COVID Isolation Enough? New BU Study Has Some Answers → https://old.reddit.com/r/COVID19/comments/vu5jz7/is_5_days_of_covid_isolation_enough_new_bu_study/10:44
BrainstormUpdates for West Bengal, India: +2889 cases, +2 deaths since a day ago — Tamil Nadu, India: +2765 cases, +1 deaths since a day ago — Guanajuato, Mexico: +1617 cases, +1 deaths since a day ago — Veracruz, Mexico: +1285 cases, +3 deaths since a day ago11:02
BrainstormNew from COVID on Twitter: Universität Bern (@unibern): Congratulations to Emma Hodcroft @ISPMBern on receiving the 2022 Johanna Dürmüller-Bol DBMR Research Award! She investigates the impact of #pandemic restrictions on the spread of the respiratory virus #EVD68. youtu.be/5UVe_wBjItM@firefoxx66 @DBMR_UniBe [... want %more?] → https://twitter.com/unibern/status/154533447769358746211:14
BrainstormNew from BMJ: Impact of the covid-19 pandemic on medical school applicants: Since 2010 the numbers of medical school places have risen by 31% (British Medical Association), with a corresponding increase in applications for those places. The Universities and Colleges... → http://www.bmj.com/content/378/bmj.o1398.short12:03
BrainstormUpdates for Russia: +3464 cases, +49 deaths since 23 hours ago — Poland: +1046 cases since a day ago12:11
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): So as pointed out time and again: vaccination remains important, also after an infection, a 3rde booster to ensure enough cells of a broad spectrum of epitopes are present is similarly important!twitter.com/Marc_Veld/stat… → https://twitter.com/Marc_Veld/status/154534859044861132812:12
BrainstormNew from EMA: What's new: Orphan: Orphan designation: Recombinant human monoclonal antibody binding to vascular adhesion protein-1, Treatment of primary sclerosing cholangitis, 19/03/2015, Positive → https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-15-146112:22
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 08JUL22 → https://old.reddit.com/r/nCoV/comments/vu7psz/global_covid_cases_for_08jul22/12:41
BrainstormNew from BBC Health: Covid infections continue to rise across the UK: An estimated 2.7 million people, or one in 25, have the virus - a rise of 18% on the week before. → https://www.bbc.co.uk/news/health-6209413713:41
BrainstormNew from Reddit (test): 08/07/22 - ZOE COVID-19 Study Update: 4,026,483 people are currently predicted to have symptomatic COVID-19 in the UK, up by 78,747. Yesterday was 3,947,736 (+2%) and last Friday was 3,461,000 (+16%). → https://old.reddit.com/r/CoronavirusUK/comments/vu8qpz/080722_zoe_covid19_study_update/13:51
BrainstormNew from Politico: British politics: UK Labour leader Keir Starmer cleared over lockdown ‘beergate’ → https://www.politico.eu/article/uk-labour-leader-keir-starmer-angela-rayner-clear-lockdown-beergate/14:01
BrainstormUpdates for Nepal: +83 cases since a day ago14:10
BrainstormNew from EMA: What's new: General: COVID-19: latest updates → https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/covid-19-latest-updates14:21
BrainstormNew from ECDC: Weekly COVID-19 country overview: This weekly report provides an overview of the epidemiological situation of the COVID-19 pandemic and COVID-19 vaccine rollout by country. → https://www.ecdc.europa.eu/en/news-events/weekly-covid-19-country-overview14:41
BrainstormNew from COVID on Twitter: Prof. Akiko Iwasaki (@VirusesImmunity): An excellent article by @patrickc highlighting the barriers for academics like myself to develop universal and nasal COVID vaccines. We need government to empower someone to intervene and lift the roadblocks. Funding alone is not enough. Please [... want %more?] → https://twitter.com/VirusesImmunity/status/154539047273835724915:01
BrainstormNew from Reddit (test): nCoV: The summer of subvariants | 08JUL22 → https://old.reddit.com/r/nCoV/comments/vua99v/the_summer_of_subvariants_08jul22/15:11
BrainstormNew from Reddit (test): nCoV: Revealed: 14,000 Kiwis reinfected with Covid - and how many have had triple dose | 07JUL22 → https://old.reddit.com/r/nCoV/comments/vuaht4/revealed_14000_kiwis_reinfected_with_covid_and/15:20
BrainstormNew from Reddit (test): nCoV: Tanzania: 8.5 Million Tanzanians Fully Vaccinated Against Covid-19 | 08JUL22 → https://old.reddit.com/r/nCoV/comments/vuased/tanzania_85_million_tanzanians_fully_vaccinated/15:30
BrainstormNew from COVID on Twitter: SARS News Network (SNN)     (@COVIDnewsfast): If you have any questions or inquired about the project please reach out to @Z_Man_NOLA  directly as he is the one running the ship, I'm merely drawing attention to his project and support it. We had a good weekend last week, let's keep up [... want %more?] → https://twitter.com/COVIDnewsfast/status/154540137760563610415:40
BrainstormNew from Reddit (test): nCoV: Uruguay suspends COVID vaccination for children under 13 | 07JUL22 → https://old.reddit.com/r/nCoV/comments/vub28w/uruguay_suspends_covid_vaccination_for_children/15:50
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Despite the >16% increase in US Covid hospitalizations (1,300 more added yesterday) over the past 10 days charts.medriva.com/us, a 17.5% test positivity, and extremely high community transmission, the @CDCgov has yet to issue a BA.5 warning pic.twitter.com/UFuuHMcW9H → https://twitter.com/EricTopol/status/154540661687429939215:59
BrainstormUpdates for Hong Kong: +2945 cases, +3 deaths since a day ago — UAE: +1666 cases, +286631 tests since a day ago16:02
BrainstormNew from r/COVID19: COVID19: Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial → https://old.reddit.com/r/COVID19/comments/vubz3i/efficacy_and_safety_of_a_single_dose_of/16:49
BrainstormUpdates for Iraq: +5031 cases since 23 hours ago — Iran: +2013 cases, +7 deaths since a day ago16:59
BrainstormNew from r/COVID19: COVID19: Increasing SARS-CoV2 cases, hospitalizations and deaths among the vaccinated elderly populations during the Omicron (B.1.1.529) variant surge in UK → https://old.reddit.com/r/COVID19/comments/vuc40j/increasing_sarscov2_cases_hospitalizations_and/16:59
BrainstormNew from Contagion Live: Prior Exposure to Staphylococcus Aureus Renders Vaccine Ineffective: A recreation of a failed staph vaccine trial unveiled that previous exposure to S aureus made the vaccine candidate ineffective. → https://www.contagionlive.com/view/prior-exposure-to-staphylococcus-aureus-renders-vaccine-ineffective17:09
BrainstormNew from ClinicalTrials.gov: (news): Rehabilitation of Critically Ill Patients With SARS-CoV-2 Variants in ICU With Limited Resources → https://clinicaltrials.gov/ct2/show/NCT0545012017:58
BrainstormUpdates for Spain: +83613 cases, +471 deaths since 2 days ago — Kosovo: +407 cases since a day ago — Cuba: +44 cases since a day ago18:01
BrainstormNew from ClinicalTrials.gov: (news): Evaluation of Effectiveness of Proprietary Rehabilitation Program in Patients After COVID-19 Infection → https://clinicaltrials.gov/ct2/show/NCT0544937918:17
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): This is our @CDCgov X No warning on BA.5X Still says 2 vaccine doses ="fully vaccinated"X Says 5 days is all that's needed for isolation when 5 days is the median length of infectiousnessX 1 in 4 age 50+ w/ 2nd booster (<-survival benefit)X Transmission is the [... want %more?] → https://twitter.com/EricTopol/status/154544924502871654418:56
BrainstormUpdates for Italy: +101863 cases, +105 deaths, +371874 tests since a day ago19:04
BrainstormNew from r/COVID19: COVID19: A patient-centric characterization of systemic recovery from SARS-CoV-2 infection → https://old.reddit.com/r/COVID19/comments/vufh5i/a_patientcentric_characterization_of_systemic/19:16
BrainstormUpdates for Japan: +40398 cases, +27 deaths since 14 hours ago — Serbia: +1599 cases, +5 deaths since a day ago — Mozambique: +83 cases, +791 tests since 22 hours ago — Canada: +914 cases since 22 hours ago21:07
BrainstormNew from BioNTech: Pfizer and BioNTech Announce U.S. FDA Approval of their COVID-19 Vaccine COMIRNATY  For Adolescents 12 through 15 Years of Age: COMIRNATY  is the first and only COVID-19 vaccine to be granted FDA approval for adolescents 12 years [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-announce-us-fda-approval-their-covid-1921:32
BrainstormNew from CIDRAP: Mixed results for nasal theophylline to treat COVID-related loss of smell: Mary Van Beusekom | News Writer | CIDRAP News Jul 08, 2022 Phase 1 and 2 trials reveal inconclusive subjective results for the drug, which opens respiratory passages. → https://www.cidrap.umn.edu/news-perspective/2022/07/mixed-results-nasal-theophylline-treat-covid-related-loss-smell21:41
BrainstormUpdates for Cyprus: +14914 cases, +4 deaths since 6 days ago — Guatemala: +6041 cases, +12 deaths since 21 hours ago — France: +141198 cases since a day ago — Malawi: +48 cases, +1 deaths since 21 hours ago22:04
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Link to the @CDCgov site which provides "community level" virus by county, a deceptive and hazardous view of our BA.5 situation now. Hidden behind that on the site is the "community transmission level," as previously shown (and below)covid.cdc.gov/covid-data-tra… [... want %more?] → https://twitter.com/EricTopol/status/154550786330853785622:49
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): BA.5 signs on in JapanNearly as vertical as Omicron BA.1, and despite a big BA.2 wave@OurWorldInData and covariants.org pic.twitter.com/9Is3zGNZt7 → https://twitter.com/EricTopol/status/154551202175544934722:59
BrainstormNew from COVID on Twitter: SARS News Network (SNN)     (@COVIDnewsfast): Going off raw community transmission the US, 98.29% of the US is experiencing moderate to extreme community transmission levels. Is this what all the minimizers meant by SARS becoming endemic?   ‍   and we have BA 5 and potentially BA 2.75 [... want %more?] → https://twitter.com/COVIDnewsfast/status/154551654823154892823:18
BrainstormNew from COVID on Twitter: SARS News Network (SNN)     (@COVIDnewsfast): Couldn't have said it better myself, infact we called this very scenario happening months ago! We have reached "endemicity through constant epidemic surge" part of the pandemic twitter.com/sheep_in_fog/s… → https://twitter.com/COVIDnewsfast/status/154552227775145984023:47

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