libera/##covid-19/ Wednesday, 2022-07-20

BrainstormUpdates for Barbados: +400 cases, +1 deaths since 21 hours ago — Trinidad and Tobago: +201 cases since 21 hours ago00:06
BrainstormUpdates for India: +20986 cases since 19 hours ago — Montenegro: +926 cases, +2 deaths since a day ago — Algeria: +55 cases since 23 hours ago01:02
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Ascending US Covid hospitalizations and deathscharts.medriva.com/us"But they're low compared with prior waves"erictopol.substack.com/p/the-pandemic… pic.twitter.com/dKFiqz8Cbg → https://twitter.com/EricTopol/status/154953314870628761601:17
LjL<Brainstorm> New from CIDRAP: CDC panel recommends Novavax vaccine as BA.5 gains more ground: Lisa Schnirring | News Editor | CIDRAP News Jul 19, 2022 BA.4 and BA.5 Omicron subvariants now make up about 90% of sequenced samples. → https://www.cidrap.umn.edu/news-perspective/2022/07/cdc-panel-recommends-novavax-vaccine-ba5-gains-more-ground01:25
LjLwait a minute, they recommend the vaccine that *doesn't* have an Omicron-specific version?01:25
Asakothought Novavax was said to have been recently found to work against all Covid03:08
Asakowhich why I was asking about a 5th shot03:08
LjLthey all "work against all covid"03:12
LjLjust, to some extent03:12
LjLdo you have evidence that Novavax works *better* against some COVID that's not the original one, compared to other vaccines?03:12
LjLi have seen none03:12
de-factohttps://arstechnica.com/science/2022/07/ba-5-skyrockets-in-us-now-accounting-for-78-of-cases/07:07
de-facto%itle07:07
de-facto%title07:07
Brainstormde-facto, the URL could not be loaded07:07
de-facto"BA.5 skyrockets in US, now accounting for 78% of cases"07:07
Asakomy local front page, just uses an AP story about how ICU patients still have scars, no mention of BA507:51
Asakohttps://apnews.com/article/ScarsofCOVIDlongrecovery-2909285039504ab5c61de4fd193ac11a07:51
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Respiratory mucosal immunity against SARS-CoV-2 following mRNA vaccinationSystemic mRNA vaccination plus mucosal adenovirus-S immunization induced strong neutralizing antibody responses, particularly at infection site: the mucosa. science.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/154965457404215705609:21
BrainstormNew from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): Reinfections are for the most part no more serious than the initial infection, mitigated by vaccination. That's not to say no symptoms, such as sore throat and fever, but usually not worse. Severe high viral loads or problems with your immune system [... want %more?] → https://twitter.com/Marc_Veld/status/154966326879656755409:52
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Immunodeficiency syndromes differentially impact the functional spectrum of SARS-CoV-2-specific T cells elicited by mRNA vaccination cell.com/immunity/fullt… → https://twitter.com/Marc_Veld/status/154966677184565248110:08
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): @EricTopol In India I think BA.2.75 might be about to cause a rise in cases & positivity ratios - in some states it is likely already doing that... See analysis below. Further down in thread I infer a (smaller) growth rate advantage also outside India. [... want %more?] → https://twitter.com/TWenseleers/status/154967694359909171310:47
BrainstormNew from BMJ: Covid-19: Up to {pound}2.7bn of public money at risk from PPE disputes, says watchdog: Up to £2.7bn of taxpayers’ money is at risk in UK government disputes with contractors over the supply of personal protective equipment (PPE) during the covid-19 pandemic, the parliamentary spending watchdog has warned.1In [... want %more?] → http://www.bmj.com/content/378/bmj.o1817.short11:35
BrainstormNew from COVID on Twitter: Dr Emma Hodcroft (@firefoxx66): In this "all #Omicron" focal build, you can see the waning of 21K/BA.1, then 21L/BA.2, & the current rise of 22A/B (BA.4/5).I can see such patterns in phylogenies a thousand times, and I still think they're fascinating.nextstrain.org/groups/neherla… [... want %more?] → https://twitter.com/firefoxx66/status/154971596704285081613:26
BrainstormNew from COVID on Twitter: Russell Bradshaw (@Forensic_Stats): 15% of England's reinfections are Omicron to Omicron. That's 15 times higher than Delta to Delta reinfection. Yet I recall earlier in the year that many people (me included, I think) were mocked for even suggesting that reinfection could occur from [... want %more?] → https://twitter.com/Forensic_Stats/status/154972228782961868914:06
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): So what happens when our governments/public health officials decide "let's pretend the pandemic is over, hold our breaths&let it rip"The sheer number of infections leads to new dominant variants appearing at increasingly short intervals.We actually told [... want %more?] → https://twitter.com/GANyborg/status/154973894674111283614:53
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): What happens when governments around the world decide it is smart to "let it rip"?The sheer number of infections dramatically increases the probability of new variants of concern appearing.Which is what we see from the figure below.Some of us tried to [... want %more?] → https://twitter.com/GANyborg/status/154974035523873177815:01
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): ...and the effectiveness of previous infection and three doses of BNT162b2 was 77.3% (95% CI, 72.4 to 81.4)". Seems I received the winning cocktail: triple vaccination & one infection... :-) nejm.org/doi/full/10.10… → https://twitter.com/TWenseleers/status/154974639603473612915:25
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Yesterday "an unprecedented nationwide daily total of over 150,000 new cases"japantimes.co.jp/news/2022/07/2… → https://twitter.com/EricTopol/status/154976449468277555516:36
BrainstormNew from Ars Technica: Science: CDC clears Novavax’s COVID-19 vaccine aimed at enticing vaccine holdouts [Updated] → https://arstechnica.com/?p=186672117:00
LjL-MatrixDraghi is speaking to parliament, this should indicate whether he wants to lead another government or he's going home17:01
BrainstormNew from BMJ: Baby who was pronounced dead has since begun to breathe, High Court judge discloses: A three month old baby who was given several brain stem tests and pronounced dead following the “irreversible cessation of brain stem functioning” has since begun to breathe, a High Court judge has disclosed.1Mr Justice [... want %more?] → http://www.bmj.com/content/378/bmj.o1831.short18:26
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Another reason for protection in some people pre-CovidHigh common cold coronavirus-specific CD4+ T cell reactivity is associated with pre-existing SARS-CoV-2immunity cell.com/cell-host-micr… @cellhostmicrobe @SetteLab pic.twitter.com/jjihHPqRYZ → https://twitter.com/EricTopol/status/154980027611821670418:58
BrainstormNew from COVID on Twitter: Yunlong Richard Cao (@yunlong_cao): Our preprint studying the antibody immune evasion and receptor-binding features of BA.2.75 is out on @biorxivpreprint.  biorxiv.org/content/10.110… → https://twitter.com/yunlong_cao/status/154980676653142425619:30
BrainstormNew from COVID on Twitter: Derek Lowe (@Dereklowe): Remember those massive virtual screening efforts against the coronavirus main protease? Ever wonder what came out of them?Not much.science.org/content/blog-p… → https://twitter.com/Dereklowe/status/154981347569790976019:54
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Also we're on track to 250k COVID-19 deaths this year; essentially because many of the most vulnerable succumbed in the two Omicron waves so far.Clearly better vaccines are needed to reduce IFR from 3%. Even better would be to suppress transmission too. → https://twitter.com/michaelzlin/status/154982176371390054520:25
BrainstormNew from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): This is unfortunate. It presupposes ASPR has performed well through the pandemics, and it has not. ASPR had the good fortunate that it’s foibles have been concealed behind CDC. The right, but harder approach, is to reform CDC; which has to be [... want %more?] → https://twitter.com/ScottGottliebMD/status/154984852235840717222:08
BrainstormNew from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): From @trvrb on current morbidity from Covid: "Given vaccination and infection, the US and global population now has widespread immunity to SARS-CoV-2 and deaths per-infection are about 10 times lower than they were pre-immunity in 2020 with a [... want %more?] → https://twitter.com/ScottGottliebMD/status/154985967532310528222:56
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Just published @NEJM During Omicron, the 2-shot mRNA vaccine effectiveness among >250,000 children age 5 to 11 years old: vs hospitalizations was very high—83%vs PCR confirmed infections 65%nejm.org/doi/full/10.10… pic.twitter.com/b2euvZnGNW → https://twitter.com/EricTopol/status/154986170641062297723:04
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): More data, replication on this today @NEJMOf monoclonal antibodies for treatment, only bebtelovimab retains strong activity vs BA.5nejm.org/doi/full/10.10……The 3 antiviral drug treatments including Paxlovid (nirmatrevilir) have not shown variant-specific [... want %more?] → https://twitter.com/EricTopol/status/154986973573869158423:35
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A discovery for how #SARSCoV2 can get into human neuronal cells by inducing tunneling nanotubes (TNT) that also enhance spread between cellsscience.org/doi/10.1126/sc…@ScienceAdvances pic.twitter.com/yzUmPX4Fgf → https://twitter.com/EricTopol/status/154987359186848153623:51
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Yet only 30% of the >28.7 million US children age 5 to 11 have been vaccinatedcovid.cdc.gov/covid-data-tra… pic.twitter.com/Bc0CvCXd6L → https://twitter.com/EricTopol/status/154987497392520396823:59

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