libera/##covid-19/ Thursday, 2022-07-21

LjL%print https://twitter.com/NightShiftMD/status/154983155508596326900:45
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LjL%title https://twitter.com/NightShiftMD/status/154983155508596326900:46
BrainstormLjL, the URL could not be loaded00:46
BrainstormLjL, the URL could not be loaded00:46
LjLbleh00:46
LjL"I’ve been an ER physician for four decades. The level of despair and pessimism ER physicians, nurses, RTs and other healthcare providers are talking about right now is unprecedented."00:46
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Assessment of #SARSCoV2 variants is usually spike-centric. The mutations from BA.2 ->BA.2.12.1->BA.4, BA.5 are shown here for the spike (left) and some outside the spike (right). Plenty occur in other parts of and may have functional significance From [... want %more?] → https://twitter.com/EricTopol/status/154989168746747084901:02
Al2O3anyone here going to work into a dense cubical situation and concerned about dying?03:25
LjLhow old are you? *dying* per se is probably not going to be a huge concern, not to say there aren't concerns03:27
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): @trvrb Chances of post-infection complications also higher with SARSCoV2 than flu, so annual COVID vax will be useful to far more people than annual flu vax (wonder if Offit is also against annually updated flu vax).Meanwhile, a follow-up thread by [... want %more?] → https://twitter.com/michaelzlin/status/154992938762102785203:33
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): New data from @CDCgov highlights importance of 2nd boosterProtection from death by boosters for age 50+ during Omicron BA.2 and BA.2.12 variantscovid.cdc.gov/covid-data-tra…29-fold reduction: 2 boosters vs unvaccinated4-fold reduction: 2nd booster vs 1 booster [... want %more?] → https://twitter.com/EricTopol/status/154994033855437619504:20
BrainstormNew from COVID on Twitter: Eli Perencevich, MD MS    (@eliowa): @EricTopol @CDCgov 29-fold for an unmatched, 2 year old vaccine. Amazing still. → https://twitter.com/eliowa/status/154994089109537177605:07
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Shows it is possible to take control and stop COVID from spreading around you, even when you only control your local environment. Even when your government is not protecting you   @utdanningsf @Udir @norsklektorlag @SLforbund @lonorge @Akademikerne [... want %more?] → https://twitter.com/GANyborg/status/154998775607141990407:23
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of AgeVaccines work.... yes, for every age! nejm.org/doi/full/10.10… → https://twitter.com/Marc_Veld/status/155002111605548646609:37
BrainstormNew from COVID on Twitter: Daniel Sheward (@DannySheward): Evasion of neutralizing antibodies by Omicron sublineage BA.2.75 biorxiv.org/content/10.110… → https://twitter.com/DannySheward/status/155003345717005926511:18
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): Highly appreciate the work that @GISAID & researchers around the world have been doing in terms of genomic surveillance to trace SARS-CoV2 variants of concern. But shame that 2.5 years into the pandemic one still has to resort to manual downloading of [... want %more?] → https://twitter.com/TWenseleers/status/155004918060492390511:26
BrainstormNew from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): 817.LongCOVID is real, and correlates with severity of illness, but even mild illness can lead to long-lasting symptoms.18.Re-infections can result in longCOVID, but the risk is much less. → https://twitter.com/Marc_Veld/status/155006817897753804912:45
BrainstormNew from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): 919.SARS-CoV-2 will continue to mutate, and will continue to infect: it won't go away.20. SARS-CoV-2 damage is very unlikely to get worse; there is no selection for this.21. It is likely that damage will diminish over time. → https://twitter.com/Marc_Veld/status/155006818063838412912:53
BrainstormNew from COVID on Twitter: Dr Emma Hodcroft (@firefoxx66): What would I like to see?- A larger conversation about the risks to MSM - also beyond primary outcome- Free accessible anonymous #monkeypox testing- Equitable availability of effective medication & vaccines- Response tie-ins with MSM [... want %more?] → https://twitter.com/firefoxx66/status/155007412145486643213:08
BrainstormNew from COVID on Twitter: Dr Emma Hodcroft (@firefoxx66): In summer 2020, we celebrated having the worst of the #SARSCoV2 pandemic behind us - with no idea what lay ahead.#Monkeypox is different, but we can still learn that earlier action, preparedness for the unknown, & open discussion are critical for an [... want %more?] → https://twitter.com/firefoxx66/status/155007412387497984013:16
BrainstormNew from COVID on Twitter: (translated) Klaas van Dijk (@KlaasvanDijk5): Behind the scenes, @IGJnl had been tackling doctors around @hapelensrob and @ZelfzorgCovid19 for months. These doctors refuse to accept that Ivermectin and HCQ do not work against corona. That has now been brought out by this group. 1/. [... want %more?] → https://twitter.com/KlaasvanDijk5/status/155008916480011469214:35
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): America Was in an Early-Death Crisis Long Before COVIDEven before the pandemic began, more people here were dying at younger ages than in comparably wealthy nations.Why healthcare should be a communal and state issue; not a commercial enterprise. [... want %more?] → https://twitter.com/Marc_Veld/status/155011826604712345816:01
BrainstormNew from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): We all wish POTUS well. With the availability of modern therapeutics, vaccines, and expert care he’s at considerably lower risk than the early days of covid. This nation has come very far in helping reduce risk for those who avail themselves of [... want %more?] → https://twitter.com/ScottGottliebMD/status/155012574014585651716:32
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): The plan & outlook for @POTUS looks good but isolation "according to CDC recommendations" would be a mistake. He needs to do rapid testing on consecutive days to show he's negative & non-infectious. CDC 5 days, no testing, is not evidence-based. + monitoring for [... want %more?] → https://twitter.com/EricTopol/status/155014187100279193717:35
BrainstormNew from COVID on Twitter: Roland Baker 2.0 (@RolandBakerIII): (2/n) Vero E6 and SARS-CoV-2 but you can imagine this might five you "brain fog" in long COVID. They have some amazing images from cryo-CLEM and cryo-ET studies. pic.twitter.com/bJsfH2iulj → https://twitter.com/RolandBakerIII/status/155015723593376153618:38
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): First report on vaccine and clinical impact of BA.5 variant from Denmark nationwide studypapers.ssrn.com/sol3/papers.cf…—good vaccination protection w/ booster especially with prior Omicron infection (94%)—increase risk of hospitalization, adjusted odds [... want %more?] → https://twitter.com/EricTopol/status/155016179874085683218:54
-Bridgestorm- 🌒 แผ่นดินไหว! 地震! Earthquake! 5.7 Mb tremor, registered by EMSC,HKOEARTHQUAKE5E,alomax, with 103 reports, 6 early, occurred 13 minutes ago (17:07:27 UTC), during a crescent moon night, Tachilek, Myanmar (21.06, 99.76) ± 4 km likely felt 410 km away by 100 people (Twitter)19:21
BrainstormNew from WebMD: Is Australia's COVID, Flu ‘Twindemic’ A Warning for the U.S.?: An alarming spike in COVID-19 and flu cases in Australia could put the U.S. on track for what health experts call a “twindemic” – a dangerous viral one-two punch in the months ahead. → https://www.webmd.com/cold-and-flu/news/20220721/australia-twindemic-a-warning-for-the-us19:33
BrainstormNew from BBC Health: (news): US President Joe Biden 'doing great' after testing positive for Covid → https://www.bbc.co.uk/news/world-us-canada-6225654420:01
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): @JoeBiden @POTUS Also everyone forgets remdesivir but a single outpatient IV dose prevented severe disease by 80%, similar to Paxlovid in similar original study populations. Biden could become the first person to get combo therapy of replicase [... want %more?] → https://twitter.com/michaelzlin/status/155018048877769523420:10
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): "antigen is genetically fused to engineered human albumin. Upon intranasal delivery, the subunit vaccines target the neonatal Fc receptor (FcRn) and induce both local and systemic antigen-specific antibody responses at magnitudes higher than after intramuscular [... want %more?] → https://twitter.com/Marc_Veld/status/155018230807393075320:20
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): Many ask about mAbs like bebtelovimab. Exogenously infused antibodies can suppress other immune functions due to negative regulation. If you're going to get boosted, then it's not good to get a big infusion of Abs → https://twitter.com/michaelzlin/status/155018439528959590420:29
BrainstormNew from StatNews: Listen: Well-paid CEOs, behind the scenes at Moderna, & Biogen’s CEO search: Does any CEO deserve $500 million a year? How did Moderna hit it big? And who wants to run Biogen? All that and more on the latest episode of "The… → https://www.statnews.com/2022/07/21/well-paid-ceos-behind-the-scenes-at-moderna-biogens-ceo-search/20:38
BrainstormNew from r/COVID19: COVID19: Operation Nasal Vaccine—Lightning speed to counter COVID-19 → https://old.reddit.com/r/COVID19/comments/w4o928/operation_nasal_vaccinelightning_speed_to_counter/20:48
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): We fully recognize the challenge of a successful nasal vaccine for high efficacy & safety, and point out why there should be optimism compared with the biology of influenza, only modest vaccine efficacy & pill treatment (Tamiflu) compared with what has been achieved [... want %more?] → https://twitter.com/EricTopol/status/155019487188903936221:07
BrainstormNew from CIDRAP: COVID-19 Scan for Jul 21, 2022: COVID vaccine in kids 5 to 11 Preterm birth with COVID-19 → https://www.cidrap.umn.edu/news-perspective/2022/07/covid-19-scan-jul-21-202221:16
BrainstormNew from r/COVID19: COVID19: Effect of Text Message Reminders and Vaccine Reservations on Adherence to a Health System COVID-19 Vaccination Policy: A Randomized Clinical Trial → https://old.reddit.com/r/COVID19/comments/w4pntd/effect_of_text_message_reminders_and_vaccine/21:54
BrainstormUpdates for Georgia: +7812 cases since 7 days ago — France: +80869 cases, +133 deaths since 3 hours ago — Burundi: +257 cases since 3 hours ago — Mozambique: +92 cases, +950 tests since 3 hours ago22:09
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): @trvrb @CorneliusRoemer @dmaccannell @GISAID In the UK pattern not clear. This is the corresponding estimated growth rate advantages from that multinomial spline model. Some sampling biases could affect this estimate (e.g. more intensive sampling of areas [... want %more?] → https://twitter.com/TWenseleers/status/155021861305916211322:41
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): @trvrb @CorneliusRoemer @dmaccannell @GISAID In Japan and to a lesser extent Nepal & Canada cases are also increasing. Probably multiple factors at play, but certainly can't be excluded that BA.2.75 contributes to this rise I would say... What do you reckon? [... want %more?] → https://twitter.com/TWenseleers/status/155021896461317734422:51
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): Wish BA.2.75 is a scariant, but looking at latest data (GISAID metadata download+data from last 5 days manually downloaded & added) I get 517 BA.2.75 sequences now, with significant growth advantage not only in India, but also in Nepal, Japan, Canada & US. [... want %more?] → https://twitter.com/TWenseleers/status/155022170310363136123:00
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): @EricTopol Wished you were right, but not so sure when I look at my latest graphs, which suggest rapid growth of BA.2.75 also in Nepal, Japan, Canada & the US (UK not so clear)... twitter.com/TWenseleers/st… → https://twitter.com/TWenseleers/status/155022596434022400423:09
BrainstormUpdates for Canada: +9377 cases, +23 deaths since 4 hours ago23:11
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): @EricTopol I believe earlier you also referred to B.1.617.2 / Delta as a scariant & questioned the causal link with the epidemic situation back then in India, twitter.com/EricTopol/stat…, twitter.com/EricTopol/stat… & more recently you questioned [... want %more?] → https://twitter.com/TWenseleers/status/155022800001217740923:19
BrainstormNew from CIDRAP: President Biden tests positive for COVID-19 as US cases rise: Lisa Schnirring | News Editor | CIDRAP News Jul 21, 2022 Biden says he's doing well and getting a lot of work done after having mild symptoms last night. → https://www.cidrap.umn.edu/news-perspective/2022/07/president-biden-tests-positive-covid-19-us-cases-rise23:28
de-facto%title https://www.reuters.com/world/us/biden-tests-positive-covid-will-continue-work-white-house-2022-07-21/23:33
Brainstormde-facto: From www.reuters.com: Biden says he is 'doing well,' working after testing positive for COVID | Reuters23:33
de-facto%title https://twitter.com/POTUS/status/155017904959886131423:34
Brainstormde-facto: From twitter.com: President Biden on Twitter: "An update from me: https://t.co/L2oCR0uUTu" / Twitter23:34
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): @TWenseleers Appreciate your points, Tom, w/ BA.2.75 data from countries w/ a BA.5 bkgd. My point on "scariants" (a word I coined) is that we needn't get carried away until we have clearcut + data, since so many have turned out to be false alarmsOthers feel [... want %more?] → https://twitter.com/EricTopol/status/155023103532493209623:37
de-facto%title https://arstechnica.com/science/2022/07/president-biden-79-tests-positive-for-covid-19/23:44
Brainstormde-facto: From arstechnica.com: President Biden, 79, tests positive for COVID-19 [Updated] | Ars Technica23:44
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Here's the list of the 12 nasal vaccines in clinical trialsthe-scientist.com/bio-business/n… @TheScientistLLC pic.twitter.com/LJzN3S3vyT → https://twitter.com/EricTopol/status/155023359255860019223:47
de-facto5title https://www.politico.com/news/2022/03/30/biden-receive-second-covid-booster-0002166723:47
de-facto%title https://www.politico.com/news/2022/03/30/biden-receive-second-covid-booster-0002166723:47
Brainstormde-facto: From www.politico.com: Biden receives 2nd Covid vaccine booster - POLITICO23:47
de-factoHence Biden got his 2nd booster 113d ago23:49
de-factothat would be ~ 1.8 half lifes if T2 ~ 60d23:50
de-factoif ramping up would take about 30d it would leave 83 days for contraction hence only 1.38 half lifes then23:53
de-factoanyhow with 27.1%=2^−(113÷60) to 2^−38% ~ ((113−30)÷60) he should be somewhat fine i guess, especially since T-cell half life is longer (and protects against severe progressions)23:57
de-factoso we know which variant he got? (most likely BA.5 i assume)23:58
de-facto*with ab level 27.1%=2^−(113÷60) to 2^−38% ~ 2^-((113−30)÷60)23:59

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