libera/##covid-19/ Monday, 2022-07-25

BrainstormNew from COVID on Twitter:    Meaghan Kall (@kallmemeg): NEW: @UKHSA COVID-19 Variant Technical Briefing Technical Briefing: BA.4/5 + BA.2.75 assets.publishing.service.gov.uk/government/upl…Short thread   pic.twitter.com/9KwHzJUAJ6 → https://twitter.com/kallmemeg/status/155132500407953408000:01
dTalLjL: to be honest that's so marginally above nominal body temp you can't even really count it as a fever01:00
dTalxx: antigen works fine for detecting the current variants. I can tell you that from personal experience :>01:01
dTalThe difficulty is that with 3 day incubation you get hardly any window where testing is actually useful01:02
xxdTal: I get mixed reports from people, very much depends on the circulating variant and what the antigen test is01:02
LjLif i or my mom (the actual person in question) are 37.4 we're going to positively feel unwell, and although i did not mention it kind of on purpose, her semi-fever followed a bad gastrointestinal event in the morning01:02
xxI suspect a lot of the antigen tests available in pharmacies are outdated, expired, improperly stored, ...01:02
LjLi suspect a lot of your assumption are pessimistic because not of hard data but of your disposition01:03
BrainstormUpdates for Argentina: +41735 cases, +76 deaths since 7 days ago01:04
dTalxx: well, add to your mixed reports that whatever the variant I had - BA.5 most likely - is robustly detected by two different brands of lateral flow, of two different "vintages", one of which I even used a q-tip because I'd lost the original swab01:04
xx¯\_(ツ)_/¯01:04
xxof course I had people tell me the tests worked too01:04
xxjust saying that I get mixed reports so definitely wouldn't trust them if my life depended on it01:05
dTalI suspect people who aren't detecting it are swabbing it wrong01:05
xxprimary care doctors are doing it wrong then too :-\01:05
xxwhich would not surprise me01:05
dTalquite likely, I'm not sure how widespread throat swabbing i01:05
dTalis01:06
LjLdTal, you throat swabbed?01:11
dTalyup01:12
LjLmy doubt with doing that is, i know in theory it can work fine, but does it work fine with the same swabs and tests?01:12
dTalyup01:12
LjLit could "work fine" so long as the test material is the correct one for it01:12
dTalthey're simple things01:12
LjLBETTER QUESTION01:12
LjLif you want to do both01:12
LjLthroat swab first and then nose swab, or...01:12
LjLand let me slowly introduce anal swabbing01:13
dTalanal swabbing isn't going to do shit, if you'll pardon the expression01:13
LjLbut the virus is known to be present longer in the stool01:13
LjLor at least some RNA of it01:13
LjL(sometimes *much* longer potentially explaining some of long covid)01:14
dTalthe point of the lateral flow test is early warning - by the time it shows up in your stool it's too late for that01:14
dTalvirus lands in the sinuses, makes its way down to the throat01:14
LjLif that's the point of lateral flow then wtf is the point of PCR?01:14
LjLbecause *that* warns early01:15
LjLlateral flow warns more or less when you get symptoms, usually01:15
LjLbut i should hush01:15
dTalMy lateral flow was robustly positive 6 hours before the first hint of symptoms01:15
dTalprobably longer, if I'd timed it right01:15
LjL"wtf is the point of PCR?" → "this guy has a point", says the politicians who make PCR unavailable01:15
LjL6 hours is very much in the vicinity of symptoms01:16
LjLyou caught it because you were very attentive and you were expecting it01:16
LjLotherwise people don't test themselves every six fucking hours :P01:16
BrainstormNew from COVID on Twitter: Jeremy Kamil (@macroliter): Gotta thank  @EricTopol  for the shout out in his latest Ground Truths. Amidst the “Covid, Season 3: Episode BA.5” situation report, he deftly reminds us that lot of our anger & frustration at each other is misplaced. The virus is the real culprit.  [... want %more?] → https://twitter.com/macroliter/status/155132809735358054401:45
BrainstormUpdates for Senegal: +85 cases since 2 days ago03:08
BrainstormNew from r/Coronavirus: Coronavirus: TWiV 921: COVID-19 clinical update #124 with Dr. Daniel Griffin | This Week in Virology → https://old.reddit.com/r/Coronavirus/comments/w799wc/twiv_921_covid19_clinical_update_124_with_dr/05:11
BrainstormNew from r/COVID19: COVID19: Persistent blood DNA methylation changes one year after SARS-CoV-2 infection → https://old.reddit.com/r/COVID19/comments/w7e4et/persistent_blood_dna_methylation_changes_one_year/05:48
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: COVID drug Evusheld in Australia's national stockpile, but many transplant patients still waiting for access → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/w7eogy/covid_drug_evusheld_in_australias_national/05:57
BrainstormNew from Reddit (test): CoronaVirus_2019_nCoV: Researchers report the detection of viral mutations associated with drug resistance in patients treated with REGEN-COV and sotrovimab → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/w7eub1/researchers_report_the_detection_of_viral/06:06
BrainstormNew from Reddit (test): Covid2019: New approach could pave the way for development of pan-coronavirus antivirals → https://old.reddit.com/r/Covid2019/comments/w7fn7x/new_approach_could_pave_the_way_for_development/06:53
BrainstormUpdates for Saitama, Japan: +12185 cases since 23 hours ago — Hyogo, Japan: +9338 cases since 23 hours ago — Kyoto, Japan: +4687 cases since 23 hours ago — Ibaraki, Japan: +2757 cases, +1 deaths since 23 hours ago08:01
BrainstormNew from r/Coronavirus: Coronavirus: Pleas for mask wearing as Australia ranks third worst for COVID cases and deaths → https://old.reddit.com/r/Coronavirus/comments/w7gtqo/pleas_for_mask_wearing_as_australia_ranks_third/08:08
BrainstormNew from Science-Based Medicine: Novavax: It’s the vaccine that scares antivaxxers, not moth DNA or any ingredient in any vaccine: The Novavax COVID-19 vaccine was recently granted emergency use approval by the FDA. Company executives and some public health officials have [... want %more?] → https://sciencebasedmedicine.org/novavax-its-the-vaccine-that-scares-antivaxxers-not-any-ingredient/09:03
BrainstormNew from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Imvanex, smallpox vaccine (smallpox and monkeypox vaccine (Live Modified Vaccinia Virus Ankara)), Smallpox Vaccine;Monkeypox virus, Date of authorisation: 31/07/2013, Revision: 21, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/imvanex10:00
BrainstormNew from Reddit (test): Covid2019: Researches found that wrist-worn health devices can be combined with machine learning to detect COVID-19 infections as early as two days before symptoms appear, and this could open the door to applying the use of wearable health tech for the [... want %more?] → https://old.reddit.com/r/Covid2019/comments/w7j2h6/researches_found_that_wristworn_health_devices/10:10
BrainstormNew from Reddit (test): Covid2019: Tunneling nanotubes provide a route for SARS-CoV-2 spreading → https://old.reddit.com/r/Covid2019/comments/w7j8d3/tunneling_nanotubes_provide_a_route_for_sarscov2/10:19
BrainstormNew from COVID on Twitter: Dr Emma Hodcroft (@firefoxx66): At @nextstrain we've designated BA.2.75 ('Centaurus') as the next #SARSCoV2 #COVID19 Nextstrain clade, 22D.Note that the decision to assign new Greek letters is up to WHO; currently everything descended from Omicron is considered Omicron. twitter.com/nextstrain/sta… → https://twitter.com/firefoxx66/status/155148212318132633810:28
BrainstormNew from r/Coronavirus: Coronavirus: Australians in hospital with COVID hit new record → https://old.reddit.com/r/Coronavirus/comments/w7jhxn/australians_in_hospital_with_covid_hit_new_record/10:38
BrainstormNew from NPR Science: How a near-death experience could change the way you live: When Randy Schiefer was hospitalized with COVID-19, he wasn't sure he would survive. Now, he looks back at that experience as the most important thing that has ever happened to him. → https://www.npr.org/2022/07/25/1112563553/near-death-experience-research11:06
BrainstormUpdates for Punjab, Pakistan: +251 cases since a day ago11:08
BrainstormNew from BioNTech: BioNTech to Report Second Quarter 2022 Financial Results and Operational Update on August 8, 2022: Mainz, Germany, July 25, 2022 (GLOBE NEWSWIRE) – BioNTech SE (Nasdaq: BNTX, “BioNTech” or “the Company”) will announce its [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-report-second-quarter-2022-financial-results-and12:50
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 25JUL22 → https://old.reddit.com/r/nCoV/comments/w7lt1o/global_covid_cases_for_25jul22/12:59
BrainstormNew from Reddit (test): Covid2019: Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody | PLOS Pathogens → https://old.reddit.com/r/Covid2019/comments/w7mepu/potent_universal_betacoronavirus_therapeutic/13:27
BrainstormNew from Reddit (test): nCoV: I’m a Virologist, and I’m Setting the Record Straight on Variants and Reinfections | 25JUL22 → https://old.reddit.com/r/nCoV/comments/w7mrkp/im_a_virologist_and_im_setting_the_record/13:46
BrainstormNew from Reddit (test): nCoV: Demonstration of a potent, universal coronavirus monoclonal antibody therapy for all COVID-19 variants | link to peer reviewed study in comments | 21JUL22 → https://old.reddit.com/r/nCoV/comments/w7myai/demonstration_of_a_potent_universal_coronavirus/13:55
BrainstormNew from Reddit (test): nCoV: COVID-19 cases top 200,000 across Japan as BA.5 strain rages | 24JUL22 → https://old.reddit.com/r/nCoV/comments/w7n5po/covid19_cases_top_200000_across_japan_as_ba5/14:05
BrainstormNew from COVID on Twitter: Bloom Lab (@jbloom_lab): Finally, I'd like to acknowledge @jianfcpku @yunlong_cao Sunney Xie et al, both for generating majority of deep mutational scanning data (nature.com/articles/s4158…) and for posting idea to improve escape maps by weighting antibodies by IC50. pic.twitter.com/gLfLBp5qYt → https://twitter.com/jbloom_lab/status/155154054045738189614:14
BrainstormNew from COVID on Twitter: Josiah Grindrod is basically endemic (@JT_Grindrod): When you go out of your way to convince people that it's a cold, why in the hell would they get regularly boosted or seek out antivirals?  No one's getting vaccinated every couple of months for a cold.  Stop blaming people for taking [... want %more?] → https://twitter.com/JT_Grindrod/status/155154478073951437114:33
BrainstormUpdates for Bhutan: +259 cases since 7 days ago15:04
BrainstormNew from BMJ: WHO calls for urgent global action to support the health of refugees and migrants: The World Health Organization has urged governments to provide accessible healthcare services for migrants and refugees that are sensitive to their needs in order to achieve the health related Sustainable Development Goals for [... want %more?] → http://www.bmj.com/content/378/bmj.o1860.short15:12
BrainstormNew from StatNews: Pharma: STAT+: Pharmalittle: White House to launch effort for new generation of Covid shots; Indian court rejects bail pleas in Biocon bribery case → https://www.statnews.com/pharmalot/2022/07/25/covid19-vaccine-biden-biocon-bribes-moderna-pfizer-paxlovid/15:31
BrainstormNew from r/COVID19: COVID19: Adverse effects of COVID-19 vaccines and measures to prevent them → https://old.reddit.com/r/COVID19/comments/w7plsg/adverse_effects_of_covid19_vaccines_and_measures/15:59
BrainstormUpdates for Zambia: +933 cases, +2 deaths, +15553 tests since 3 days ago — Liechtenstein: +93 cases, +1 deaths since 3 days ago16:00
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): In the US, >2.5 million doses of Paxlovid have been given and  it "is one of the fastest selling medicines in history, with Pfizer forecasting annual sales of $22bn this year" ft.com/content/0eb0b4… —is that enough profit @Pfizer?—what happens when we [... want %more?] → https://twitter.com/EricTopol/status/155157203289831424016:19
BrainstormNew from r/COVID19: COVID19: HDL cholesterol levels and susceptibility to COVID-19 → https://old.reddit.com/r/COVID19/comments/w7qrt4/hdl_cholesterol_levels_and_susceptibility_to/16:48
LjLde-facto: here's a controversial academic comment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167431/17:05
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Comprehensive assessment of symptoms from a large #LongCovid non-hospitalized cohort w/ matched controls—increased risk with younger age—largest hazard ratios: loss of smell, hair loss, reduced libido, ejaculation difficultynature.com/articles/s4159… [... want %more?] → https://twitter.com/EricTopol/status/155158334263763353617:07
BrainstormNew from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): This pre-print could take us one step towards explanation the non-A-E hepatitis epidemic in kids. What's still not explained is why the combinations of the normally non-pathogenic AAV viruses contribute to severe illness now. (Sign of previous SARSCoV2 [... want %more?] → https://twitter.com/GANyborg/status/155158680329927065717:17
BrainstormNew from Politico: Ischgl COVID victims could get payout after Austrian court ruling: Authorities did not provide 'correct and complete' information as coronavirus swept through ski resort. → https://www.politico.eu/article/austrian-court-rule-ischgl-covid-victim-compensation/17:46
BrainstormNew from COVID on Twitter: Prof. Shane Crotty (@profshanecrotty): Excellent article on the value of mucosal immunity by @VirusesImmunity and @EricTopol. Prof Iwasaki has been a champion of mucosal immunity vaccine research for at least a decade, and it is definitely important.science.org/doi/10.1126/sc… → https://twitter.com/profshanecrotty/status/155159547746799206617:55
BrainstormNew from COVID on Twitter: Prof. Shane Crotty (@profshanecrotty): Consistent with our earlier work with the excellent @DonnaFarber3 , now with the important added value of comparison to COVID vax. This is likely another way that hybrid immunity helps protect against diverse SARS-CoV-2 variants. science.org/doi/10.1126/sc… → https://twitter.com/profshanecrotty/status/155159775340643532818:06
BrainstormUpdates for Micronesia: +249 cases, +1 deaths since 22 hours ago18:11
de-factoLjL, hmm yeah controversal article indeed, i find it a bit disturbing that the author fails to elaborate the benefit vs risk concept that is commonly accepted to evaluate the usefullness of vaccinations. Rather the author just seems to try to bash all the potential negative effects without even trying to quantify the real prevalence of mentioned effects18:34
de-factoleaving me with the impression that his writing is all but unbiased tbh18:35
BrainstormNew from WebMD: Hair Loss, Impotence Join List of Long COVID Symptoms: Researchers report that people with long-haul COVID experience a wider set of symptoms than once thought, including hair loss and sexual dysfunction. → https://www.webmd.com/lung/news/20220725/hair-loss-impotence-join-list-of-long-covid-symptoms18:35
de-factoalso from my understanding some things he mentioned are simply wrong18:37
de-factofor example there were no HIT antibodies in vector vaccines seen, but the phenomena was similar to HIT antibodies induced problems18:38
de-factodetails ok, but still showing that he did not care to read up on his claims in detail18:38
de-factohonestly i think the author does not really know what he is talking about there18:42
BrainstormUpdates for Serbia: +5105 cases, +8 deaths, +14532 tests since 22 hours ago — Italy: +24117 cases, +104 deaths, +122550 tests since 23 hours ago19:01
BrainstormNew from WebMD: Hospital Programs Tackle Mental Health Effects of Long COVID: New programs target one of the hardest-hit groups of patients: people with the psychological effects of long COVID. → https://www.webmd.com/lung/news/20220725/hospital-programs-tackle-long-covid19:52
BrainstormNew from COVID19 Vaccine Tracker: valerie: Airlangga University: UNAIR Inactivated COVID-19 Vaccine → https://covid19.trackvaccines.org/vaccines/181/20:01
BrainstormNew from r/COVID19: COVID19: Factors associated with reversals of COVID-19 vaccination willingness: Results from two longitudinal, national surveys in Japan 2021-2022 → https://old.reddit.com/r/COVID19/comments/w7vt3q/factors_associated_with_reversals_of_covid19/20:58
BrainstormUpdates for South Africa: +848 cases, +12 deaths, +17882 tests since 2 days ago — Sri Lanka: +75 cases, +2 deaths since 22 hours ago20:59
BrainstormNew from StatNews: STAT+: Pfizer loses another court battle alleging the U.S. illegally limits use of copay assistance programs: A federal appeals court panel upheld a ruling which found that programs Pfizer wanted to launch to provide copay assistance for drugs would violate kickback laws. → https://www.statnews.com/pharmalot/2022/07/25/pfizer-copay-kickbacks-medicare-hhs/21:27
BrainstormNew from CIDRAP: News Scan for Jul 25, 2022: VA stewardship intervention COVID vaccine and heart attack, stroke Avian flu in Florida poultry CCHF in Spain → https://www.cidrap.umn.edu/news-perspective/2022/07/news-scan-jul-25-202221:46
BrainstormNew from CIDRAP: COVID-19 antivirals may cut risk of hospitalization, death: Mary Van Beusekom | News Writer | CIDRAP News Jul 25, 2022 Paxlovid and molnupiravir stood out in a meta-analysis that compared the effectiveness of 16 different drug or drug combinations. → https://www.cidrap.umn.edu/news-perspective/2022/07/covid-19-antivirals-may-cut-risk-hospitalization-death21:55
BrainstormUpdates for Brunei: +5166 cases since 2 days ago — France: +129929 cases, +210 deaths since 2 days ago — Armenia: +965 cases, +4 deaths since 6 days ago — Burundi: +587 cases since 3 days ago22:01
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaquesAlso against HIV: vaccines will eventually come to the rescue: another step:science.org/doi/10.1126/sc… → https://twitter.com/Marc_Veld/status/155165808876320358422:04
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Continuing on this theme:SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translationNSP2 protein encoded by SARS-CoV-2 virus further impedes translation of Ifnb1 mRNApnas.org/doi/10.1073/pn… → https://twitter.com/Marc_Veld/status/155166018724061184222:14
\mSgliterally day after positive test/symptom onset. GP prescribed a z-pack and prednisone. Am I crazy?22:32
LjL?22:32
\mSgIs that the latest standard of care? I would think prednisone would weaken the immune system letting the virus run rampant?22:33
LjLi have no idea what the standard of care is in various places to be honest22:33
LjLand i don't know what a z-pack is22:34
LjLi believe here people are told to just wait, take paracetamol if they feel the need, and call if saturation goes below 92%22:34
\mSgantibiotic - azithromycin22:34
\mSgIt hit 91% for a moment this morning.22:34
LjLi don't know the rationale why you'd be prescribed an antibiotic early22:34
LjLdo you have a pneumonia?22:35
LjLdo you have an unusual medical history that your GP knows about?22:35
\mSgtouch of asthma - has been a little hard to breath.22:35
LjLthat probably explains the reason behind the prednisone22:36
xx\mSg: still better than if they just told you to drink water and call an ambulance if you can't breathe22:40
xx¯\_(ツ)_/¯22:40
ecksi don't think we do cortison before day 7 or so but maybe they're treating it as an asthma exacerbation22:50
\mSgIt's just scary, as I think early on, when there was no standard, when drs were treating it as just a bad cold, a lot had the idea of giving systemic corticosteroids too early and ended up worse-off because it let the virus florish with no immune system fighting back.22:55
\mSgI guess it is a gamble vs the asthma exacerbation. ugh.22:56
LjL\mSg, maybe you can discuss whether there are other non-immune-impacting choices for asthma23:05
LjLwe can't go ahead and give you medical advice here, and i certainly wouldn't know how to23:05
LjLbut you should interact with your doctor, it shouldn't be a one-way thing23:05
BrainstormUpdates for Canada: +1265 cases since a day ago23:09
\mSgGetting a 2nd opinion should help.23:12
BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Symptoms and risk factors for long COVID in non-hospitalized adults>12 weeks-62 symptoms were significantly associated with SARS-CoV-2-Increased risk: younger, female, ethnicity, smoking, socioeconomic deprivation, obesity, ... nature.com/articles/s4159… → https://twitter.com/Marc_Veld/status/155167914296128717523:31

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