libera/##covid-19/ Friday, 2022-10-07

BrainstormNew from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir TreatmentOnly 2 vs 7; but, Paxlovid does not impede the immune reaction with a robust antibody and T cell [... want %more?] → https://twitter.com/Marc_Veld/status/157814204734494310500:02
BrainstormNew from Reddit (test): nCoV: Health minister says next Covid wave may come at end of year | 06OCT22 → https://old.reddit.com/r/nCoV/comments/xxhpy7/health_minister_says_next_covid_wave_may_come_at/00:12
BrainstormNew from Reddit (test): nCoV: Covid: Hong Kong to lure tourists with free air tickets | 06OCT22 → https://old.reddit.com/r/nCoV/comments/xxhzw1/covid_hong_kong_to_lure_tourists_with_free_air/00:22
BrainstormNew from The Lancet (Online): [Correspondence] WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed: An essential line of defence in a global living-with-COVID-19 policy is formed by effective therapeutic strategies for vulnerable patients,1 many of whom are [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01938-9/fulltext00:31
BrainstormNew from COVID on Twitter: David LV Bauer (@DavidLVBauer):  Clinical and in vitro evidence suggests urgent reassessment of @WHO's Therapeutics and COVID-19 Living Guideline on monoclonal antibodies is needed.   Out today @TheLancet from @TheCrick and @UCLHresearch, work led by @MaryYiWeiWu :: [... want %more?] → https://twitter.com/DavidLVBauer/status/157815280929567129601:00
BrainstormUpdates for Canada: +8556 cases, +120 deaths since 21 hours ago01:04
BrainstormNew from BioNTech: BioNTech and Australia’s State of Victoria Form Strategic Partnership to Establish mRNA Research Center and Manufacturing Facility: BioNTech and Australia’s State of Victoria will establish an mRNA research and innovation center to [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/biontech-and-australias-state-victoria-form-strategic01:38
BrainstormNew from WebMD: Heart Failure in a Post-Quarantine World: Diagnosed with heart failure during the COVID pandemic, one woman learned how to live with the condition -- and to thrive with it. → https://www.webmd.com/features/post-covid-heart-failure01:57
BrainstormUpdates for California, United States: +13089 cases since 18 hours ago02:06
BrainstormNew from COVID on Twitter: Theo Sanderson (@theosanderson): So this is the increase in intra-delta diversification before it was all squelched by omicron pic.twitter.com/HkFgzroNJv → https://twitter.com/theosanderson/status/157818539491055206402:55
BrainstormUpdates for Australia: +12040 cases, +42 deaths since a day ago — Nigeria: +236 cases since 2 days ago — Zimbabwe: +87 cases, +1 deaths, +1792 tests since 2 days ago — Canada: +8253 cases since 7 hours ago03:08
BrainstormNew from r/COVID19: COVID19: A randomized, placebo-controlled trial of a nasal spray solution containing broadly potent neutralizing antibodies against SARS-CoV-2 variants in healthy volunteers → https://old.reddit.com/r/COVID19/comments/xxmex0/a_randomized_placebocontrolled_trial_of_a_nasal/03:54
BrainstormNew from Politico: Preparing for the UK’s first ‘unlocked’ winter: With a potential COVID-19 surge in the coming months, infrastructure, testing, access and treatment all need to be in place, particularly for the most vulnerable → https://www.politico.eu/sponsored-content/preparing-for-the-uks-first-unlocked-winter/05:00
BrainstormUpdates for Germany: +174112 cases, +117 deaths since 23 hours ago05:07
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): New on MolnupiravirA randomized trial of ~26,000 patients with Covid, mean age 57 with 2 days of symptoms, showed no difference in hospitalizations or deaths, the primary endpoint, compared with usual carepapers.ssrn.com/sol3/papers.cf… pic.twitter.com/HIF845BRLx → https://twitter.com/EricTopol/status/157822041702976716805:10
BrainstormUpdates for Belgium: +12874 cases, +26 deaths since 3 days ago06:09
BrainstormUpdates for Micronesia: +2863 cases, +13 deaths since a day ago06:59
BrainstormNew from r/Science: science: Study finds SARS-COV-2 encodes a protein that turns off our viral defense genes → https://old.reddit.com/r/science/comments/xxq4pu/study_finds_sarscov2_encodes_a_protein_that_turns/07:32
BrainstormUpdates for Baden-Wurttemberg, Germany: +42600 cases, +24 deaths since 23 hours ago — North Rhine-Westphalia, Germany: +25848 cases, +22 deaths since 23 hours ago — Lower Saxony, Germany: +16266 cases, +18 deaths since 23 hours ago — Massachusetts, United States: +9942 cases since 6 days ago08:01
BrainstormNew from r/COVID19: COVID19: Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients → https://old.reddit.com/r/COVID19/comments/xxrq6d/rapid_initiation_of_nasal_saline_irrigation_to/08:29
BrainstormNew from COVID on Twitter: Michael Lin, MD PhD   (@michaelzlin): One can make the case that everything will be regular approval from now on, but it's a bit rich for FDA to complain about trial conduct after what they let slide for molnupiravir and Pfizer's vax for young kids → https://twitter.com/michaelzlin/status/157827785049849446508:58
BrainstormNew from r/Coronavirus: Daily Discussion Thread | October 07, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/xxs8l8/daily_discussion_thread_october_07_2022/09:07
BrainstormUpdates for Taiwan: +50725 cases, +52 deaths, +65387 tests since 23 hours ago10:05
BrainstormNew from Science-Based Medicine: Science and Medicine: Does the Mass Infection of Unvaccinated Young People Follow the “Basic Principles of Public Health”? → https://sciencebasedmedicine.org/does-the-mass-infection-of-unvaccinated-young-people-follow-the-basic-principles-of-public-health/11:00
BrainstormNew from BMJ: Learning networks in the pandemic: mobilising evidence for improvement: Key messagesThe paucity of evidence during the early phase of the pandemic provided an opportunity for real time learning driven by communities of practiceLearning from these communities led to clinical and service innovationA mix of [... want %more?] → http://www.bmj.com/content/379/bmj-2022-070215.short11:57
BrainstormNew from r/Coronavirus: Coronavirus: Nearly 4 mln Americans received updated COVID boosters last week - CDC → https://old.reddit.com/r/Coronavirus/comments/xxv8zs/nearly_4_mln_americans_received_updated_covid/12:35
BrainstormUpdates for China: +4657 cases, +2 deaths since 19 hours ago13:06
BrainstormNew from COVID on Twitter: Jeffrey Barrett (@jcbarret): Delta and Omicron both represented immunological jumps from their predecessors AND were more inherently transmissible. Quantifying exactly how much became difficult because of changing population immunity, but I think consistent evidence that both played a role [... want %more?] → https://twitter.com/jcbarret/status/157834052665425510513:14
BrainstormNew from BBC Health: Covid: Protect elderly from rising virus levels in UK: With cases on the up, people who feel unwell are advised to avoid vulnerable relatives as a precaution. → https://www.bbc.co.uk/news/health-6317000613:53
BrainstormUpdates for Hong Kong: +4369 cases, +2 deaths since 21 hours ago — Saudi Arabia: +139 cases, +2 deaths since 23 hours ago — France: +24 cases since 15 hours ago14:02
BrainstormNew from BMJ: Covid-19: Don’t let economic crisis distract from preparing for a future pandemic, conference hears: Most countries haven’t learnt all the lessons of the covid pandemic and need to take further measures to ensure their health systems are resilient enough in the event of another pandemic, a conference on [... want %more?] → http://www.bmj.com/content/379/bmj.o2417.short14:31
nyuszika7h5/b 11814:58
nyuszika7hoops14:58
BrainstormNew from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): What else unites us? Once upon a time there were shared values. Now? What are we collectively for or against?Not against COVID-19.Not against Russia.Not even against fascism.We are not even united for our planet, nature or our humanity!Or are [... want %more?] → https://twitter.com/Marc_Veld/status/157836830520674304115:01
BrainstormNew from Reddit (test): nCoV: Global COVID Cases For 07OCT22 → https://old.reddit.com/r/nCoV/comments/xxyuvy/global_covid_cases_for_07oct22/15:20
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): New and encouraging @NatureMedicine on bivalent Beta booster"These results indicate that bivalent booster vaccines can induce potent, durable and broad antibody responses against multiple variants, providing a new tool in response to emerging [... want %more?] → https://twitter.com/EricTopol/status/157837955838591795315:49
BrainstormNew from COVID on Twitter: Prof. Akiko Iwasaki (@VirusesImmunity): Absolutely fantastic thesis defense being delivered by soon to be doctor @tianyangmao, spanning RIG-I antiviral approaches to #PrimeandSpike nasal vaccines   @YaleIBIO @YaleMed pic.twitter.com/EQlQRt7syP → https://twitter.com/VirusesImmunity/status/157839130788981965116:38
BrainstormNew from COVID on Twitter: Tom Wenseleers (@TWenseleers): A single epidemic wave per year in our endemic coronaviruses. Would be nice: I wonder when we'll get there with SARS-CoV2, now that we'll be on our 4th wave this year alone, and on our 8th since the start of the pandemic... twitter.com/ELwollants/sta… [... want %more?] → https://twitter.com/TWenseleers/status/157839665378192588816:58
BrainstormUpdates for Singapore: +5934 cases since 18 hours ago — Canada: +10185 cases, +111 deaths since 20 hours ago17:02
BrainstormNew from ClinicalTrials.gov: (news): Effects of Peer Support and Progressive Relaxation Exercises on Sleep Quality and Anxiety → https://clinicaltrials.gov/ct2/show/NCT0557077317:07
BrainstormNew from ClinicalTrials.gov: (news): Cerebral Oxymeter and End Tidal Carbondioxide Values Under Surgical Drapes With and Without Past COVID-19 Infection → https://clinicaltrials.gov/ct2/show/NCT0557168317:27
BrainstormNew from ClinicalTrials.gov: (news): Personalized Computerized Training Program for Cognitive Dysfunction After COVID-19 → https://clinicaltrials.gov/ct2/show/NCT0557185217:37
BrainstormNew from ClinicalTrials.gov: (news): Immunogenicity of COVID-19 Vaccines in Tuberculosis Patients → https://clinicaltrials.gov/ct2/show/NCT0557173517:56
BrainstormUpdates for Netherlands: +11603 cases, +29 deaths since a day ago18:04
BrainstormNew from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): But eventually SARS-CoV-2 will also have a place on the virus calendar and our collective and individual immunity will have found a balance with the virus. Except the aforementioned groups. Unfortunately for them there will be a new enduring threat. → https://twitter.com/Marc_Veld/status/157841505108586905718:06
LjL-Matrixde-facto, tuvix, dTal, etc: I am unexpectedly about to get my fourth dose, don't know if BA.1 or BA.5 or even if I'll be given the choice... Assuming I will, have you heard anything new about BA.5 human trials, or how it seems to be faring in the US?18:47
BrainstormNew from COVID on Twitter: Meaghan Kall (@kallmemeg): NEW: @UKHSA COVID-19 Variant Technical Briefing 46   Update on Omicron lineages BA.2.75*, BF.7, BQ.1*assets.publishing.service.gov.uk/government/upl… pic.twitter.com/d0t9rElY1I → https://twitter.com/kallmemeg/status/157842629408971161619:04
BrainstormUpdates for Italy: +44665 cases, +62 deaths, +205555 tests since a day ago — Canada: +10317 cases, +113 deaths since 23 hours ago19:07
LjL-MatrixToo late, they gave me 4/519:09
LjL-MatrixI asked about lack of testing on humans but she convincedly lied that they are all thoroughly tested19:10
LjL-MatrixSo whatever, I am not able to get confrontational except when people piss me off19:10
LjL-MatrixAnd I also can't see in a crystal ball whether in hindsight, 4/5 will have been better or worse than 119:11
LjL-MatrixI should have remembered from past times though not to remove the entire hoodie but only a sleeve though, because I'm probably just movement impaired but I couldn't put it back on without immediately moving the jabbed arm a lot19:12
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): A new profile on @Tuliodna & team's work @ScienceMagazine, a champion of African science contributions, a leading force for the pandemicscience.org/content/articl… by @meredithwadman w/@DrTedros @firefoxx66 @LuciousChabuka @FortunateNatwi1 @christian_happi [... want %more?] → https://twitter.com/EricTopol/status/157843060043161600019:13
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): In a large US cohort of ~200,000 people who had Covid, vaccination reduced the risk of #LongCovid by 30-40% and this protection persisted through breakthrough infectionsmedrxiv.org/content/10.110… → https://twitter.com/EricTopol/status/157843791185846681619:42
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): New weekly US genomic surveillance covid.cdc.gov/covid-data-tra…BA.5 continues to fade as BA.2.75x creeps up, BF.7 (BA.5.2.1.X)  & BA.4.6 gainCompare w/ new UK report today, via @kallmemegassets.publishing.service.gov.uk/government/upl…Main difference is [... want %more?] → https://twitter.com/EricTopol/status/157844355404035686420:02
BrainstormUpdates for Spain: +10843 cases, +206 deaths since 3 days ago20:03
Asakoi would wait for a novavax booster, if it happens20:24
BrainstormNew from StatNews: STAT+: Merck’s Covid-19 pill was no better than placebo in lowering the risk of hospitalization: A Merck pill used to combat Covid-19 failed to demonstrate it can lower the risk of hospitalization compared with a placebo among adults at a higher risk from [... want %more?] → https://www.statnews.com/pharmalot/2022/10/07/covid19-merck-molnupiravir-fda-mhra-hospitalization/20:30
LjL↑↑↑↑↑20:38
LjLfuck molnupiravir20:38
LjLde-facto20:38
LjLexcept it's so paywalled it doesn't even let me click on the visible "preliminary results" link20:40
LjLbut it's https://www.statnews.com/wp-content/uploads/2022/10/PANORAMIC_Molnupiravir_preprint-version-3.0_final.pdf anyway20:41
BrainstormNew from ##covid-19 Zotero group: Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): preliminary analysis from the United Kingdom randomised, controlled open-label, platform adaptive trial: Type Journal Article Author [... want %more?] → https://www.zotero.org/groups/covid_links/items/DDZQRPPG20:50
de-factohey LjL how is your arm doing?20:54
LjLfine for now20:54
de-factogood to hear20:55
LjLalthough now i remember why the other times i didn't take off my hoodie entirely but only removed one sleeve20:55
LjLbecause i twisted my arm in every possible way to put it back on this time :P20:55
de-factoso you got the very latest Wuhan-Hu-1 +  BA.5 bivalent shot?20:55
LjLyes, the shiny new untested shot20:55
de-factoPfizer or Moderna?20:56
de-factoerm20:56
de-factoBioNTech/Pfizer or Moderna20:56
* LjL-Matrix uploaded an image: (154KiB) < https://libera.ems.host/_matrix/media/r0/download/matrix.org/uKczyOYrwzUlKDosJVQdoAlH/IMG_20221007_190901.jpg >20:57
LjL-LabRatde-facto, ↑20:57
LjL-LabRati'm sorry, it doesn't even say BioNTech ;(20:58
LjL-LabRatI think it does on the green pass20:59
LjL-LabRatwonder if I'll get a new one...20:59
LjL-LabRatespecially with this impromptu non-booked administration20:59
BrainstormNew from COVID on Twitter: Eric Topol (@EricTopol): Why do some people develop blood pressure dysregulation after severe Covid?science.org/doi/10.1126/sc…@ScienceAdvances by @UChicagoPME @UChicago @srouhani1 and collaborators pic.twitter.com/G5X7hIbHHC → https://twitter.com/EricTopol/status/157845781430064742420:59
LjL-LabRaton the green pass it says Comirnaty21:00
LjL-LabRatbut I guess they figured many people have never heard this name and would freak out, "you're giving me the russian vaccine?!" :P21:00
de-factoimho Moderna got the best name, Spikevax, easy to remember21:02
LjL-LabRat"Moderna" is even easier and so that's what everyone calls it :P21:14
BrainstormNew from FDA Press Releases: FDA: FDA Approves Vaccine for Use During Third Trimester of Pregnancy to Prevent Whooping Cough in Infants Younger Than Two Months of Age → http://www.fda.gov/news-events/press-announcements/fda-approves-vaccine-use-during-third-trimester-pregnancy-prevent-whooping-cough-infants-younger-two21:19
AsakoTwiv has a podcast on the bivalent21:43
BrainstormNew from CIDRAP: News Scan for Oct 07, 2022: COVID, underlying illness in kids Polio in 6 countries US flu markers rise CWD on Wisconsin deer farm → https://www.cidrap.umn.edu/news-perspective/2022/10/news-scan-oct-07-202221:57
BrainstormUpdates for France: +61164 cases, +53 deaths since 23 hours ago — United Kingdom: +2 deaths since a day ago22:01
BrainstormNew from CIDRAP: US teen athletes suffered during pandemic, study shows: Stephanie Soucheray | News Reporter | CIDRAP News Oct 07, 2022 Teens reported low physical activity, poor quality of life, and high rates of anxiety and depression in May 2020. → https://www.cidrap.umn.edu/news-perspective/2022/10/us-teen-athletes-suffered-during-pandemic-study-shows22:17
BrainstormNew from WebMD: At the Front Lines of Long COVID, Local Clinics Prove Vital: Big name hospital chains across the U.S. are opening dedicated centers to help patients dealing with long COVID. But so are the lower profile clinics and hospitals run by cities, counties and states → https://www.webmd.com/lung/news/20221005/at-the-front-lines-of-long-covid-local-clinics-prove-vital22:45
LjL-MatrixApart from lack of a proper human trial for the BA.4/5 vaccine, don't you all have the feeling these vaccines are being left a little to themselves, so to speak? Maybe it's just that I don't pay as much attention as I used to, and in turn, media don't pay attention to the reports so Brainstorm doesn't post them here... but... by now shouldn't we have a number of semi-anedoctal reports on its efficacy vs the BA.1 one and vs the original? Etc22:51
LjL-Matrixetc? I haven't seen it22:51
LjL-LabRatouchies my arm, it was pretty fine until now, then it suddenly decided to bite me23:12
TimvdeLjL-LabRat: I got my vaccine yesterday, barely even had a sore arm23:14
LjL-LabRatTimvde, which vaccine23:14
TimvdePfizer, I *think* the BA.1 one, but I'm actually not entirely sure23:15
LjL-LabRatlol23:15
LjL-LabRatas i said23:15
LjL-LabRatwe're grown vaccine-ignoring23:15
LjL-LabRatyeah it's probably whaaaaat... the one not tested on humans? yeah must be that one, maybe23:15
TimvdeI do wonder if it was good to take the BA.1 vaccine if I recently-ish got COVID, likely BA.523:17
TimvdeBut de-facto didn't reply :(23:17
LjL-LabRatyou probably called it Pfizer23:17
TimvdeI didn't say a brand then :P23:17
TimvdeLet's see if I can download my vaccine passport yet23:17
TimvdeMaybe it has more information23:18
LjL-LabRati hope i'll be able to get mine without issues, since this "booking" was a bit messed up23:21
TimvdeNope, it doesn't say...23:21
LjL-LabRatin theory i'm still waiting "24/48 hours" (it's already been longer) after my "enabling request" that i had to do for nobody knows what reason23:21
LjL-LabRatso they just let me in, but i bet Lombardy's bureau-informatique will have more surprise for me23:21
LjL-LabRatmaybe they'll give me a 5th shot23:22
LjL-LabRatso far I haven't received any SMS or email about my vaccine, but it's early23:22
LjL-LabRatyeah it still says i can't book because my code has already an enabling request pending23:23
LjL-LabRatbet it'll pend and pend and pend...23:23
de-factoTimvde, i got BA.5 last week, i plant to wait at leat 3-6months for my immune reaction to learn from it undisturbed23:27
de-factoafaik the old recommendation from STIKO was 6 months, but they may have shortened it to 3 months or such23:28
de-factobasically for me it means enduring the winter wave with the immunity from the infection23:28
LjL-Matrix3-4 should be the ideal from what I've heard most recently23:29
de-factoi think it makes sense as the immune cells will need some time to do the somatic hypermutations and optimizations, selecting the best and promoting them to memory B-cells for storage in the bones23:29
Timvdede-facto: it was 3 months ago23:29
TimvdeProbably got infected the 1st of July23:29
de-factowell... then you are an edge case i guess23:29
de-factoi cant decide for you, but if you are not in a risk group i probably would wait in your place23:30
TimvdeI already got it :P23:30
Timvdeso too late anyway23:30
de-factowell then its at least the 3 months that are also (at least) recommended by the STIKO23:31
LjL-Matrixdoes the STIKO recommend getting COVID? because clearly you've both already failed their recommendations!23:32
Timvdede-facto: but it being BA.1 while I had BA.5 shouldn't have any negative effects on my protection against BA.5, right?23:32
de-factolol nope it recommends a minimum time to wait counting from last "immunological event (such as vax or infection)23:32
TimvdeIf I got "exposed" to another variant, I'd expect that to result in broader immunity23:33
de-factoTimvde, maybe it even broadens the spectrum of your immune repertoire?23:33
TimvdeYea, that's what I'm wondering about :P23:33
de-factobut afaik June/July was just the transition between BA.2 and BA.5 (at least in Germany)23:33
TimvdeIt may either broaden the immunity, or put focus back on the wrong mutations23:34
LjL-Matrixbut, the other vaccine is against BA.1 anyway, not BA.2, isn't it?23:34
Timvdede-facto: I believe it was like 80% BA.5 here at that point, but I may be mistaken23:34
de-factoTimvde, i think it either broadens the immunity or would just re-activate the cells that recovered you from your last infection23:34
LjL-MatrixI wouldn't mind a BA.2 vaccine since it seems pretty prolific with subvariants from the little I've looked23:35
de-factoI dont think it will put a wrong focus23:35
Timvdede-facto: cool, thanks :)23:36
LjL-Matrixconsidering they found that the BA.1 vaccine has some kind of original antigenic sin going on, such that it doesn't result in even 2x the antibodies compared to the regular vaccine, do we have any similar information about the BA.4/5 vaccine? Okay it's not had a proper human trial, but surely we should know how much it makes the antibodies go up?23:36
de-factoTimvde, i think the other way is more beneficial, e.g. if the last vaccination is long time ago the immune system possibly may be more "plastic" to learn from an infection (and that actual variant)23:38
de-factothough that also means less protection from the vaccination (that was long time ago) against that infection23:39
de-factoso its again as always: risk vs benefit23:39
TimvdeYea, that was the case :) Got my previous vaccine in December, got my infection in July, just over 6 months later23:39
de-factoyeah so heh, you got the virus as 6 months and the booster at 3 months then, exactly in the range of 3-6 month23:40
de-factofor me it was even 9 1/2 months after my 3rd Moderna (also in Dec 21)23:40
LjL-Matrixsame23:46
LjL-Matrixwell for me it was the vaccine, but still, the immunological event :P23:46

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