| Brainstorm | Updates for Canada: +541 cases since 3 hours ago | 00:08 |
|---|---|---|
| Brainstorm | New from r/Science: science: Study finds that risk of myocarditis after SARS-CoV-2 vaccination is increased but very low → https://old.reddit.com/r/science/comments/z1ci6j/study_finds_that_risk_of_myocarditis_after/ | 00:18 |
| Brainstorm | New from The Lancet (Online): [Articles] Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019: The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02185-7/fulltext | 00:37 |
| Asako | any thoughts on getting free antibody testing being offerfed at our gym | 01:03 |
| Brainstorm | Updates for Monaco: +41 cases since 3 days ago | 01:11 |
| Brainstorm | New from BBC Health: How many Covid cases does China have and what are its rules?: Covid-19 is flaring up in China, despite it having some of the toughest lockdown rules in the world. → https://www.bbc.co.uk/news/59882774 | 01:24 |
| LjL | Asako, free, why not? | 01:46 |
| LjL | "The US and other Western nations have offered China mRNA vaccines, which might be more effective - but they have not been widely used in mainland China." | 01:49 |
| LjL | why? because they have not really been "offered", or do they think they are not as good as they purport to be, or just pride in their own vaccines? | 01:50 |
| LjL | (which we don't seem to consider very good over here>) | 01:50 |
| Brainstorm | Updates for Bulgaria: +397 cases, +13 deaths, +6164 tests since 23 hours ago — Norway: +167 cases since 23 hours ago | 02:00 |
| gry | https://www.thedailybeast.com/scientists-make-breakthrough-in-developing-a-new-vaccine-that-could-finally-beat-covid do you know how does the 'natural response' work? like when people or animals get sick with the virus and are trying to fight it. does natural immunity target the non-mutating part or mutating part? | 02:05 |
| LjL | natural immunity can't tell one from the other | 02:06 |
| gry | right. and what does it target in its response? | 02:07 |
| LjL | %wik epitope | 02:07 |
| Brainstorm | LjL, from English Wikipedia: An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a [... want %more?] → https://en.wikipedia.org/wiki/Epitope | 02:07 |
| gry | That's the general term. | 02:07 |
| LjL | yes, well, that's the general answer. as i said, it can't target a mutating or a non-mutating epitope, because there is no difference between the two. | 02:08 |
| LjL | it will target whatever. | 02:08 |
| gry | Of a few million people, what does it most commonly target? | 02:08 |
| LjL | I don't really know, it probably tends to target what is most "visible" from the outside, but it may vary a lot by person | 02:09 |
| LjL | There are other efforts for pan-sarbecovirus vaccines, by the way | 02:10 |
| LjL | Hopefully we'll get there because I'm a bit tired of this ailment even though I haven't even had it | 02:10 |
| LjL | Generally speaking an average human being will react with immunity that is not very well targeted (to the point that you can even have autoimmune "boomerang" responses) | 02:11 |
| LjL | (or even ADE) | 02:11 |
| LjL | which I guess is why we look for neutralizing antibodies, i.e. the ones that are really good at stopping the virus from reproducing if you attach the antibody to it, and then we make the best ones into monoclonal antibodies to inject | 02:12 |
| LjL | with perhaps some provisos, the same ones may be good candidates for a vaccine, but indeed some of them will neutralize something that can mutate very easily, which is useful in the short term but not so good in the long term, while others may target something maybe less obviously useful to the virus, but still important, and less amenable to mutating | 02:13 |
| LjL | in a pinch, we went "this uses the spike protein to enter cells, in particular the receptor binding domain is the thing that, err, binds to cell receptors, so we'll target that one". that worked well at first. but now I do think we should look for less obvious targets | 02:14 |
| -Bridgestorm- ⭕ Earthquake! 6.7 Mi tremor, registered by 6 agencies, occurred 13 minutes ago (02:03:11 UTC), during daytime, Honiara, Solomon Islands (-9.71, 159.68) ± 15 km, ↓18 km likely felt 470 km away (in Honiara…) by 54600 people (earthquake.usgs.gov) | 03:16 | |
| Brainstorm | New from Reddit (test): Am I really suffering from long covid brain fog？: Before I was diagnosed with long covid in November 2020, I had several months of persistent fatigue, fever, loss of smell and taste, and consulted several doctors in different specialties. → https://old.reddit.com/r/Covid2019/comments/z1i1du/am_i_really_suffering_from_long_covid_brain_fog/ | 03:38 |
| -Bridgestorm- ⭕ Earthquake! 7.0 Mww tremor, registered by PT, occurred 41 minutes ago (02:03:07 UTC), during daytime, Honiara, Solomon Islands (-9.79, 159.6), ↓14 km likely felt 520 km away (in Honiara…) by 54600 people (service.iris.edu) | 03:44 | |
| Brainstorm | New from r/Coronavirus: Coronavirus: Women are struggling to regain lost ground in the workforce after COVID-19 → https://old.reddit.com/r/Coronavirus/comments/z1i5dp/women_are_struggling_to_regain_lost_ground_in_the/ | 04:16 |
| Asako | what use is it to know one's Antibody levels, if I've had 5 shots already | 04:51 |
| LjL | antibodies wane | 05:02 |
| LjL | faster than we'd like | 05:02 |
| Brainstorm | New from r/Coronavirus: Coronavirus: US pandemic death toll higher than in 20 peer countries → https://old.reddit.com/r/Coronavirus/comments/z1jbmq/us_pandemic_death_toll_higher_than_in_20_peer/ | 05:03 |
| Brainstorm | Updates for Germany: +41676 cases, +199 deaths since 2 days ago | 05:07 |
| Asako | so if the number was low, be more cautious ? or | 05:16 |
| Brainstorm | New from r/COVID19: COVID19: SARS-CoV-2 exposure in Norwegian rats (Rattus norvegicus) from New York City → https://old.reddit.com/r/COVID19/comments/z1kmm2/sarscov2_exposure_in_norwegian_rats_rattus/ | 06:28 |
| Brainstorm | Updates for Unknown, China: +25303 cases since 23 hours ago — North Rhine-Westphalia, Germany: +11976 cases, +54 deaths since 2 days ago — New York, United States: +6977 cases, +22 deaths since 23 hours ago — Illinois, United States: +5544 cases, +21 deaths since 2 days ago | 06:59 |
| Brainstorm | New from Virology.ws: Trial By Error: The Long COVID Survival Guide and the Role of Patients in Research: By David Tuller, DrPH “The Long COVID Survival Guide: How to Take Care of Yourself and What Comes Next—Stories and Advice from Twenty Long-Haulers [... want %more?] → https://www.virology.ws/2022/11/22/trial-by-error-the-long-covid-survival-guide-and-the-role-of-patients-in-research/ | 08:03 |
| Brainstorm | Updates for Taiwan: +18169 cases, +38 deaths, +31068 tests since a day ago | 09:04 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | November 22, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/z1nxwk/daily_discussion_thread_november_22_2022/ | 09:09 |
| Brainstorm | New from EMA: What's new: Orphan: Orphan designation: Recombinant chimeric monoclonal antibody against CD20 (ublituximab), Treatment of chronic lymphocytic leukaemia, 26/11/2009, Positive → https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-09-699 | 09:19 |
| Brainstorm | Updates for Japan: +99094 cases, +136 deaths since 23 hours ago | 10:06 |
| Brainstorm | New from StatNews: Why doesn’t the U.S. have at-home flu tests?: “It's really rare, and it's really new, that people are allowed to know about what's happening inside their body without a physician in the middle,” says Michael Mina, a former… → https://www.statnews.com/2022/11/22/why-doesnt-the-u-s-have-at-home-flu-tests/ | 10:46 |
| Brainstorm | Updates for Lithuania: +490 cases, +1 deaths since a day ago | 11:02 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 22NOV22 → https://old.reddit.com/r/nCoV/comments/z1pugy/global_covid_cases_for_22nov22/ | 11:15 |
| Brainstorm | New from EMA: What's new: Medicine: Human medicines European public assessment report (EPAR): Jcovden (previously COVID-19 Vaccine Janssen), COVID-19 vaccine (Ad26.COV2-S [recombinant]), COVID-19 virus infection, Date of authorisation: 11/03/2021, Revision: 25, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/jcovden-previously-covid-19-vaccine-janssen | 11:34 |
| Brainstorm | Updates for Slovenia: +1606 cases since 23 hours ago — Poland: +597 cases, +8 deaths, +7616 tests since 23 hours ago — France: +304 cases since 14 hours ago | 12:05 |
| Brainstorm | New from r/Science: science: At least two thirds of Australians, including children and adolescents, have had COVID-19. This is more than double the number of cases reported based on nose and throat swab testing for the virus. Vaccination reduces the risk of developing severe [... want %more?] → https://old.reddit.com/r/science/comments/z1qdzp/at_least_two_thirds_of_australians_including/ | 12:14 |
| Brainstorm | New from Reddit (test): nCoV: US pandemic death toll higher than in 20 peer countries | 21NOV22 → https://old.reddit.com/r/nCoV/comments/z1r77x/us_pandemic_death_toll_higher_than_in_20_peer/ | 12:33 |
| Brainstorm | New from Reddit (test): nCoV: New studies enrich knowledge of genetic factors that naturally protect people against COVID-19 | 21NOV22 → https://old.reddit.com/r/nCoV/comments/z1rb42/new_studies_enrich_knowledge_of_genetic_factors/ | 12:42 |
| Brainstorm | Updates for Indonesia: +7644 cases, +51 deaths, +89337 tests since 22 hours ago — Hong Kong: +7139 cases, +13 deaths since 23 hours ago | 13:07 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Veklury, remdesivir, Coronavirus Infections, Date of authorisation: 03/07/2020, Revision: 15, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/veklury | 13:40 |
| Brainstorm | New from ProPublica: The U.S. Promised Tribes They Would Always Have Fish, but the Fish They Have Pose Toxic Risks: by Tony Schick , Oregon Public Broadcasting , and Maya Miller , ProPublica This article was produced for ProPublica’s Local Reporting Network in partnership with Oregon [... want %more?] → https://www.propublica.org/article/how-the-us-broke-promise-to-protect-fish-for-tribes | 14:09 |
| Brainstorm | New from r/COVID19: COVID19: Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults → https://old.reddit.com/r/COVID19/comments/z1ti31/use_of_cardiopulmonary_exercise_testing_to/ | 14:28 |
| Brainstorm | New from EMA: What's new: Document: List of critical medicines for COVID-19 public health emergency (PHE) under Regulation (EU) 2022/123 → https://www.ema.europa.eu/documents/other/list-critical-medicines-covid-19-public-health-emergency-phe-under-regulation-eu-2022/123_en.pdf | 15:27 |
| Brainstorm | Updates for Singapore: +2388 cases since 23 hours ago — Azerbaijan: +58 cases, +2 deaths since a day ago — Malta: +18 cases since a day ago | 16:01 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Regkirona, regdanvimab, COVID-19 virus infection, Date of authorisation: 12/11/2021, Revision: 5, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/regkirona | 16:16 |
| Brainstorm | New from r/COVID19: COVID19: Factors associated with vaccine-induced T cell immune responses against SARS-CoV-2 in kidney transplant recipients → https://old.reddit.com/r/COVID19/comments/z1wh2h/factors_associated_with_vaccineinduced_t_cell/ | 16:35 |
| Brainstorm | New from r/Science: science: Progress towards a Hepatitis-C vaccine: researchers built a 3D map of the E1E2 protein from the surface of the virus, a molecule thought to be the best candidate as a vaccine target, using cryo-electron microscopy → https://old.reddit.com/r/science/comments/z1wkzh/progress_towards_a_hepatitisc_vaccine_researchers/ | 16:45 |
| Brainstorm | New from StatNews: U.K. analysis shows one dose of monkeypox vaccine yields strong protection: An analysis released Tuesday by U.K. health officials indicates that even one dose of the monkeypox vaccine provides strong protection against the virus. → https://www.statnews.com/2022/11/22/u-k-analysis-shows-one-dose-of-monkeypox-vaccine-yields-strong-protection/ | 17:05 |
| Brainstorm | Updates for Bosnia and Herz.: +72 cases, +4 deaths since a day ago | 17:10 |
| Brainstorm | New from StatNews: Real-world data show updated Covid-19 boosters increase protection against infection: The updated Covid-19 boosters increase people’s protection against symptomatic infection from the coronavirus, according to some of the first estimates of [... want %more?] → https://www.statnews.com/2022/11/22/data-show-updated-covid-19-boosters-increase-protection-against-infection/ | 17:43 |
| -Bridgestorm- 🏠 Earthquake! Sismo! 6.0 M tremor, registered by 4 agencies, with 11 reports, 3 early, occurred 9 minutes ago (16:39:10 UTC), during daytime, Baja California, Mexico (30.72, -116.33), ↓10 km likely felt 320 km away (in Ensenada, San Diego, Tijuana…) by 5.2 million people → https://twitter.com/SismologicoMX/status/1595095776447041537 https://twitter.com/SSNMexico/status/1595095782587129856 (Twitter) | 17:48 | |
| Brainstorm | New from r/COVID19: COVID19: Extraordinary new video animation of SARS-CoV-2 viral life cycle by structural biologists. → https://old.reddit.com/r/COVID19/comments/z1y4qa/extraordinary_new_video_animation_of_sarscov2/ | 17:54 |
| -Bridgestorm- ⭕ Earthquake! Sismo! 6.2 Mw tremor, registered by EMSC, occurred 19 minutes ago (16:39:12 UTC), during daytime, Baja California, Mexico (30.7, -116.46) likely felt 310 km away (in Camalú, Vicente Guerrero, Lázaro Cárdenas, Emiliano Zapata, Lomas de San Ramón, Santa Fe…) by 68800 people (www.seismicportal.eu) | 17:59 | |
| Brainstorm | Updates for Switzerland: +21246 cases since 2 hours ago | 18:06 |
| Brainstorm | New from r/Coronavirus: Coronavirus: New omicron-specific boosters show modest benefit, CDC study says → https://old.reddit.com/r/Coronavirus/comments/z1yfjj/new_omicronspecific_boosters_show_modest_benefit/ | 18:23 |
| Brainstorm | New from WebMD: Without Guidelines, Docs Make Their Own Long COVID Protocols: Treating the condition requires equal combinations of skill, experience, and intuition, and doctors waiting for guidelines have started cobbling together treatment plans designed to ease the worst symptoms. → https://www.webmd.com/lung/news/20221122/docs-make-their-own-long-covid-protocols | 19:01 |
| Brainstorm | New from Contagion Live: Genetic Factors That Naturally Protect Against Severe COVID-19: A Brazilian study of people 90 years and older who easily recovered from COVID-19 identified specific genetic components that may have provided protection. → https://www.contagionlive.com/view/genetic-factors-that-naturally-protect-against-severe-covid-19 | 19:11 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: FACT SHEET: Biden Administration Announces Six-Week Campaign to Get More Americans their Updated COVID-19 Vaccine Before End of the Year | The White House → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/z20l9l/fact_sheet_biden_administration_announces_sixweek/ | 19:21 |
| Brainstorm | New from WebMD: A Growing List of Musicians Sidelined Due to Long COVID: For many artists, it’s the elephant in the room they don’t want to talk about in an industry that depends on people being around one another. → https://www.webmd.com/lung/news/20221122/growing-list-of-musicians-sidelined-due-to-long-covid | 19:49 |
| Brainstorm | Updates for Tuvalu: +418 cases since 23 hours ago — Canada: +674 cases, +2 deaths since 23 hours ago | 20:04 |
| Brainstorm | New from r/COVID19: COVID19: The lifecycle of SARS-CoV-2 → https://old.reddit.com/r/COVID19/comments/z21icu/the_lifecycle_of_sarscov2/ | 20:19 |
| Brainstorm | New from CIDRAP: Study finds 10-fold return on COVID vaccine investment: Mary Van Beusekom | News Writer | CIDRAP News Nov 22, 2022 Each dollar invested in New York City COVID-19 vaccine efforts generated $10.19 in savings, data reveal. → https://www.cidrap.umn.edu/news-perspective/2022/11/study-finds-10-fold-return-covid-vaccine-investment | 20:38 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Warning to anyone who’s had Covid over side effect which could impact you daily → https://old.reddit.com/r/CoronavirusUK/comments/z22tzr/warning_to_anyone_whos_had_covid_over_side_effect/ | 20:47 |
| Brainstorm | Updates for Venezuela: +13910 cases since 14 hours ago — Serbia: +667 cases, +3 deaths since a day ago — France: +612 cases since 22 hours ago | 21:00 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Experts are concerned Thanksgiving gatherings could accelerate a 'tripledemic' → https://old.reddit.com/r/Coronavirus/comments/z237ng/experts_are_concerned_thanksgiving_gatherings/ | 22:24 |
| Brainstorm | New from WebMD: Why Some Groups Vaccinate Less: Misinformation could lead to widening vaccine disparities in babies and toddlers. Here’s what parents need to know to protect their kids. → https://www.webmd.com/children/features/why-some-groups-vaccinate-less | 22:43 |
| Brainstorm | New from r/Coronavirus: Coronavirus: Fauci gives final briefing after 50 years in government → https://old.reddit.com/r/Coronavirus/comments/z26c0x/fauci_gives_final_briefing_after_50_years_in/ | 23:22 |
| Brainstorm | New from CIDRAP: Jim Wappes: Remdesivir, steroids tied to better COVID hospital outcomes → https://www.cidrap.umn.edu/news-perspective/2022/11/remdesivir-steroids-tied-better-covid-hospital-outcomes | 23:41 |
| Brainstorm | New from WebMD: Fauci Urges Americans 'One Last Time' to Get COVID Shots: Anthony Fauci, MD, stood at the White House press briefing podium “one last time” as he bid farewell to reporters on Tuesday ahead of stepping down as director of the National Institute of [... want %more?] → https://www.webmd.com/vaccines/covid-19-vaccine/news/20221122/fauci-urges-americans-to-get-covid-vaccines | 23:51 |
| gry | hmm, nice timing | 23:58 |
| gry | who is going to be the next big fauci guy now? | 23:58 |
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