| LjL | look at like | 00:24 |
|---|---|---|
| LjL | https://outbreak.info/location-reports?loc=ESP | 00:24 |
| LjL | https://outbreak.info/location-reports?loc=ITA | 00:24 |
| LjL | https://outbreak.info/location-reports?loc=FRA | 00:24 |
| LjL | https://outbreak.info/location-reports?loc=GRC | 00:24 |
| LjL | maybe not https://outbreak.info/location-reports?loc=DEU so much | 00:24 |
| LjL | not the big graphs with the variants, but the tiny graph just below with the amount of sampling | 00:24 |
| LjL | and then tell me we haven't just collectively decided to, like, stop doing that | 00:25 |
| Brainstorm | New from r/COVID19: COVID19: COVID-19 testing: When to test, how accurate are home tests and more → https://old.reddit.com/r/COVID19/comments/tpv9op/covid19_testing_when_to_test_how_accurate_are/ | 00:52 |
| Brainstorm | Updates for Germany: +5968 cases, +3 deaths since 6 hours ago | 01:04 |
| camelia[m] | Is this true? "asymptomatic infections tend not to produce antibodies (compared to symptomatic infections, which do)" | 01:13 |
| LjL | camelia[m], i don't know, there's not a lot of information about asymptomatic infections. however consider that with Omicron and BA.2 in particular, it seems that people can get re-infected quite easily anyway, symptoms or not | 01:18 |
| LjL | camelia[m], but i'm seeing a few random papers that say asymptomatic infections *do* produce antibodies | 01:19 |
| LjL | "It is clear that adaptive immunity is strongly activated during asymptomatic infection, but some features of the T cell and antibody response may differ from those in symptomatic disease." https://www.nature.com/articles/s41577-021-00631-x | 01:19 |
| LjL | "Some studies find that severer, symptomatic infections (although, not lethal infection) tend to be associated with a higher or more enduring viral load, greater immune priming and higher levels of antibodies, neutralizing antibodies and CD4+ T cell and CD8+ T cell responses41, while others find mild disease poorly correlates with the levels of neutralizing antibodies but is significantly associated with the magnitude of CD4+ T cell and CD8+ T cell responses42." | 01:20 |
| LjL | (same paper) | 01:20 |
| LjL | %title https://pubmed.ncbi.nlm.nih.gov/34578138/ | 01:20 |
| Brainstorm | LjL: From pubmed.ncbi.nlm.nih.gov: Asymptomatic COVID-19 Individuals Tend to Establish Relatively Balanced Innate and Adaptive Immune Responses - PubMed | 01:20 |
| LjL | title speaks for itself | 01:20 |
| LjL | %title https://www.sciencedirect.com/science/article/pii/S2666379121001038 | 01:20 |
| Brainstorm | LjL: From www.sciencedirect.com: Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies - ScienceDirect | 01:20 |
| Brainstorm | Updates for Samoa: +182 cases since a day ago | 02:07 |
| Brainstorm | New from r/COVID19: COVID19: Case Report of Breakthrough Long COVID and the Use of Nirmatrelvir-Ritonavir → https://old.reddit.com/r/COVID19/comments/tpwe3o/case_report_of_breakthrough_long_covid_and_the/ | 02:08 |
| LjL | https://assets.researchsquare.com/files/rs-1443341/v1/83b00a40-22f8-4e35-95d4-9fcae3433b16.pdf?c=1647355938 | 02:20 |
| LjL | err, yeah, that's what Brainstorm posted | 02:20 |
| LjL | anyway a case report of administering Paxlovid apparently resolving long COVID symptoms | 02:20 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Debunking a myth that future variants will inevitably be more mild, less pathogenic:"The severity associated with future SARS-CoV- 2 variants is inherently unpredictable."medrxiv.org/content/10.110… by @davidandthebees @emcat1 an d collaborators pic.twitter.com/8KQ5nx17li → https://twitter.com/EricTopol/status/1508243149436567552 | 02:47 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): No wonder BA.2 is causing so much transmissibility trouble— ~175,000 nasopharyngeal samples analyzed for viral load— BA.2 nearly twice as much as BA.1 medrxiv.org/content/10.110… → https://twitter.com/EricTopol/status/1508245714714779648 | 02:57 |
| Brainstorm | Updates for Vanuatu: +373 cases since a day ago | 03:03 |
| Brainstorm | New from NPR Science: The FDA is expected to authorize 2nd boosters for people 50 and up: People aged 50 and over could soon be eligible for a second Pfizer-BioNTech or Moderna COVID vaccine booster. The administration wants to offer the shots [... want %more?] → https://www.npr.org/sections/health-shots/2022/03/27/1089072803/the-fda-is-expected-to-authorize-2nd-boosters-for-people-50-and-up | 03:16 |
| Brainstorm | Updates for Thailand: +24635 cases, +81 deaths since a day ago | 05:09 |
| LjL | Shanghai being locked down and mass tested | 05:43 |
| de-facto | hmm very interesting case report, Delta infection after two mRNA doses 6 months ago, long-COVID with persistent symptoms plateau 5 month post infection, 6 months post infection possibly Omicron infection, tested negative after few days but was started on Paxlovid anyhow, long-COVID symptoms rapidly disappeared and claimed back to normal 7 months after initial infection | 05:48 |
| de-facto | suggesting some ongoing infection or viral reservoir not cleared out completely after initial infection, then possibly antibodies ramping up again with second infection plus antiviral possibly finally cleared the pathogen from her body | 05:50 |
| de-facto | presumably at least | 05:50 |
| de-facto | possibly the immune system under constant stress (by ongoing infection or even other dormant viruses awakening), yet not really clearing it up | 05:51 |
| de-facto | %title https://europepmc.org/article/ppr/ppr469834 | 05:52 |
| Brainstorm | de-facto: From europepmc.org: Europe PMC | 05:52 |
| de-facto | %title https://www.researchsquare.com/article/rs-1443341/v1 | 05:53 |
| Brainstorm | de-facto: From www.researchsquare.com: Case Report of Breakthrough Long COVID and the Use of Nirmatrelvir-Ritonavir | Research Square | 05:53 |
| de-facto | maybe some research into SARS-CoV-2 sanctuaries in human bodies should be done | 05:55 |
| de-facto | or quasi-sanctuaries such as on the edge to e.g. guts microbiome, where it could replicate but immune reaction that normally would be neutralizing in other parts of the body would not fully neutralize it "on the edge" or such? | 05:58 |
| de-facto | (speculation) | 05:58 |
| Brainstorm | New from r/Science: science: Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber → https://old.reddit.com/r/science/comments/tq0hdo/faruvc_222_nm_efficiently_inactivates_an_airborne/ | 06:04 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: As evidence favoring boosters mounts, half of eligible U.S. residents haven't gotten theirs - Several new studies show booster shots improve protection against Covid infection, hospitalization and death → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/tq2ejc/as_evidence_favoring_boosters_mounts_half_of/ | 07:49 |
| Brainstorm | Updates for Saitama, Japan: +3938 cases, +8 deaths since a day ago — Ibaraki, Japan: +1293 cases since a day ago — Iwate, Japan: +265 cases since a day ago — Cook Islands, New Zealand: +138 cases since 2 days ago | 08:04 |
| Brainstorm | New from r/COVID19: COVID19: Inconsistent directions of change in case severity across successive SARS-CoV-2 variant waves suggests an unpredictable future → https://old.reddit.com/r/COVID19/comments/tq2k84/inconsistent_directions_of_change_in_case/ | 08:08 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | March 28, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/tq3got/daily_discussion_thread_march_28_2022/ | 09:05 |
| Brainstorm | New from COVID on Twitter: Tulio de Oliveira (@Tuliodna): Before going to the beach this morning, I deposited the genomics results coming out in the weekend in South Africa. All most recent genomes from mid-end of March are BA.2, no delta or recombinant. Thanks our team working hard so I can take a small break :) → https://twitter.com/Tuliodna/status/1508346269193932800 | 09:44 |
| Brainstorm | New from BBC Health: (news): Covid: Rules on masks and self-isolation end in Wales → https://www.bbc.co.uk/news/uk-wales-60875244 | 09:54 |
| Brainstorm | New from BMJ: Covid-19: Researchers call for routine flu testing of hospital inpatients with SARS-CoV-2 infection: All hospital inpatients with covid-19 should be routinely tested for influenza viruses, as those who are co-infected have much worse outcomes, researchers have said.The largest study to date of... → http://www.bmj.com/content/376/bmj.o809.short | 10:33 |
| Brainstorm | New from StatNews: Opinion: Unexpectedly united: The parallel plights of two communities 2,000 miles apart wracked by the pandemic: I constantly straddle two disparate worlds. One is in Boston, where I work as a Harvard-affiliated physician. The other is in [... want %more?] → https://www.statnews.com/2022/03/28/unexpectedly-united-parallel-plights-two-disparate-communities-hard-hit-by-covid/ | 10:52 |
| Brainstorm | Updates for France: +1 deaths since 12 hours ago | 11:06 |
| Brainstorm | New from ProPublica: Cuomo Set Out to “Transform” Mental Health Care for Kids. Now They Can’t Get Treatment.: by Abigail Kramer , THE CITY, photography by Sarah Blesener This article was produced for ProPublica’s Local Reporting Network in [... want %more?] → https://www.propublica.org/article/cuomo-set-out-to-transform-mental-health-care-for-kids-now-they-cant-get-treatment#1286414 | 11:12 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 28MAR22 → https://old.reddit.com/r/nCoV/comments/tq5nw5/global_covid_cases_for_28mar22/ | 11:47 |
| Brainstorm | New from COVID on Twitter: John Burn-Murdoch (@jburnmurdoch): Extremely excited to be on a panel with the brilliant @_HannahRitchie @BristOliver @puzzlesthewill next Tuesday at @RoyalStatSoc, talking about how data & graphics have been used (and misused...) to communicate all things Covid.Sign up here for free! [... want %more?] → https://twitter.com/jburnmurdoch/status/1508393769149808642 | 12:45 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): A reminder; vaccinations work, also in South Korea where the booster rate is high amongst the elderly, but unfortunately, with victims are seen under the young. But, compare with Hong Kong where booster rates for the elderly are much less (+vaccine differences). [... want %more?] → https://twitter.com/Marc_Veld/status/1508403681544310787 | 13:24 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 variant transition in the Swedish population reveals higher viral quantity in BA.2 casesBA.2 has about a 2x higher viral load by PCR.medrxiv.org/content/10.110… → https://twitter.com/Marc_Veld/status/1508410763538489345 | 13:53 |
| Brainstorm | New from r/COVID19: Weekly Scientific Discussion Thread - March 28, 2022: This weekly thread is for scientific discussion pertaining to COVID-19. Please post questions about the science of this virus and disease here to collect them for others and clear up post space for [... want %more?] → https://old.reddit.com/r/COVID19/comments/tq7npo/weekly_scientific_discussion_thread_march_28_2022/ | 14:03 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): Data from Chinese Government shows that over 52 million people aged 60+ haven’t been vaccinated with any Covid vaccine. Booster rates also low; only 56.4% of people age 60-69 having received booster shot, and 48.4% of people age 70-79. [... want %more?] → https://twitter.com/ScottGottliebMD/status/1508422801996328970 | 14:54 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The march of mutations of #SARSCoV2 as it progressively evades our immune response, gets more contagiousnytimes.com/interactive/20… twitter.com/nytopinion/sta… pic.twitter.com/N5djD5EqcA → https://twitter.com/EricTopol/status/1508433643412213763 | 15:28 |
| Brainstorm | Updates for Canada: +2845 cases, +14 deaths since 20 hours ago | 16:00 |
| Brainstorm | New from Science Daily: Less antibody diversity as we age: As we age, our immune system works less well. We become more susceptible to infections and vaccinations no longer work as effectively. A research team has investigated whether short-lived killifish also undergo aging of the immune system. Indeed, they [... want %more?] → https://www.sciencedaily.com/releases/2022/03/220328092103.htm | 16:12 |
| de-facto | %title https://www.bbc.com/news/world-asia-china-60893070 | 16:19 |
| Brainstorm | de-facto: From www.bbc.com: Shanghai Covid: China announces largest city-wide lockdown - BBC News | 16:19 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): BA.2 in China"Fifty-two million people aged over 60 years are yet to be fully vaccinated. The most vulnerable — those aged over 80 years — are the least well vaccinated, with only 20% having received the primary vaccination course and booster [... want %more?] → https://twitter.com/EricTopol/status/1508449419733045252 | 16:32 |
| Brainstorm | New from Reddit (test): nCoV: China's COVID-19 spike preceded by surge in cases from Hong Kong | 28MAR22 → https://old.reddit.com/r/nCoV/comments/tqar2s/chinas_covid19_spike_preceded_by_surge_in_cases/ | 16:41 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Similar findings in new report of booster with original mRNA vaccine vs Omicron-specific vaccine in the mouse modelcell.com/cell/fulltext/… → https://twitter.com/EricTopol/status/1508457421324181514 | 17:01 |
| Brainstorm | Updates for Bhutan: +780 cases, +1 deaths, +3474 tests since a day ago | 17:03 |
| Brainstorm | New from ClinicalTrials.gov: (news): A Phase 1 SAD/MAD Study of RLS-0071 in Healthy Volunteers in Support of a COVID-19 Development Program → https://clinicaltrials.gov/ct2/show/NCT05298787 | 17:11 |
| Brainstorm | New from ClinicalTrials.gov: (news): Parental Health Decision-making for Children During the COVID-19 Pandemic → https://clinicaltrials.gov/ct2/show/NCT05298865 | 17:42 |
| Brainstorm | New from ClinicalTrials.gov: (news): Paediatric VLA2001-321 Study → https://clinicaltrials.gov/ct2/show/NCT05298644 | 17:51 |
| Brainstorm | Updates for Greece: +27489 cases, +73 deaths, +113940 tests since 23 hours ago — Germany: +142206 cases, +66 deaths since 23 hours ago — United Kingdom: +50 cases since a day ago | 17:59 |
| Brainstorm | New from ClinicalTrials.gov: (news): The Effect of Working at Home to Reduce Risk of Respiratory Infection → https://clinicaltrials.gov/ct2/show/NCT05298488 | 18:02 |
| Brainstorm | New from ClinicalTrials.gov: (translated) Combined Immunization of COVID-19 Inactivated Vaccine With QIV and PPV23: Conditions: Safety; Immunogenicity, Vaccine; COVID-19 Vaccines; Influenza Vaccines; Pneumococcal Vaccines → https://clinicaltrials.gov/ct2/show/NCT05298800 | 18:21 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Towards understanding the basis for #LongCovid brain fog and its resemblance to "chemo-brain," among other recent studies washingtonpost.com/health/2022/03… by @arianaeunjung w/ @michelle_monje @VirusesImmunity twitter.com/EricTopol/stat… pic.twitter.com/q6NuIAGX4a → https://twitter.com/EricTopol/status/1508479948960382976 | 18:32 |
| Brainstorm | Updates for Ireland: +19932 cases, +11 deaths since 3 days ago | 19:08 |
| Brainstorm | New from BMJ: Faith based dialogue can tackle vaccine hesitancy and build trust: One in 10 Americans say that their religious beliefs prohibit them from getting covid-19 vaccines,1 and similar reports have emerged globally.2 Vaccine hesitancy tied to religious faith can undermine... → http://www.bmj.com/content/376/bmj.o823.short | 19:20 |
| Brainstorm | New from WebMD: Going Back to the Office During a Pandemic? Here's Some Help: While some workers can't wait to get back to the office, others are anxious, resistant, and concerned. Here are some tips to help with the transition. → https://www.webmd.com/lung/news/20220328/back-to-the-office-blues | 19:49 |
| Brainstorm | Updates for United Kingdom: +214392 cases, +216 deaths since 2 hours ago — Italy: +31560 cases, +95 deaths, +211535 tests since a day ago — Canada: +12 deaths since 20 hours ago | 20:05 |
| LjL | what, that's like twice the usual UK case count? | 20:07 |
| LjL | %cases uk | 20:07 |
| Brainstorm | LjL: United Kingdom has had 20.8 million confirmed cases (31.4% of all people) and 165046 deaths (0.8% of cases; 1 in 403 people) as of 2 minutes ago. 500.7 million tests were done (7.5 per capita, 4.2% positive). 51.8 million were vaccinated (78.0%). +214392 cases, +216 deaths since 2 hours ago. See https://coronavirus.data.gov.uk/ | 20:07 |
| LjL | wow, https://coronavirus.data.gov.uk/details/cases?areaType=overview&areaName=United%20Kingdom is stuck at March 25 | 20:08 |
| LjL | http://offloop.net/covid19/?default=United%20Kingdom&cumulative=no&legacy=no (unsmoothed) makes it pretty obvious they've changed the way they count them :\ | 20:09 |
| `St0ner | damn LjL how do you stay on top of all this? do you work professionally in stats/research/public policy? | 20:17 |
| LjL | i don't stay on top of it... | 20:17 |
| LjL | i just see what my bot posts and stuff | 20:17 |
| Brainstorm | New from CDC (old): Coronavirus [CoV]: COVID-19 Travel Recommendations by Country → https://tools.cdc.gov/api/embed/downloader/download.asp | 20:27 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Paxlovid is a virus-directed pill, highly effective independent of variants.Now a pill that is host-directed, against the TMPRSS 2 receptor, also pan-#SARSCov2, with much potential, including as a preventive Rx, @Nature todaynature.com/articles/s4158… pic.twitter.com/h7Ya1hOrDx → https://twitter.com/EricTopol/status/1508510909659983876 | 20:37 |
| Brainstorm | New from CIDRAP: News Scan for Mar 28, 2022: Impact of COVID contact tracing Antibiotic stewardship in the NICU US flu on the rise MERS in Qatar → https://www.cidrap.umn.edu/news-perspective/2022/03/news-scan-mar-28-2022 | 22:03 |
| Brainstorm | New from COVID on Twitter: Josiah 'So Mild' Grindrod (@JT_Grindrod): Still omicron though twitter.com/EricTopol/stat… → https://twitter.com/JT_Grindrod/status/1508534848352243713 | 22:12 |
| Brainstorm | New from CIDRAP: COVID-19, flu an especially dangerous pair: Mary Van Beusekom | News Writer | CIDRAP News Mar 28, 2022 Adult COVID-19 patients also infected with the flu are 4 times more likely to need mechanical ventilation and 2.4 times more likely to die. → https://www.cidrap.umn.edu/news-perspective/2022/03/covid-19-flu-especially-dangerous-pair | 22:22 |
| Brainstorm | New from Medical Xpress: Can COVID-causing coronavirus outwit human innate immune response?: As Americans cross their fingers, hoping the pandemic stays behind them, scientists across the country remain focused on the novel coronavirus, intent on combating its next move. → https://medicalxpress.com/news/2022-03-covid-causing-coronavirus-outwit-human-innate.html | 22:42 |
| Brainstorm | New from COVID on Twitter: Prof. Shane Crotty (@profshanecrotty): Crotty lab journal club by @P1RAD:Here is an immunological reason to resist raw cookie dough: Salmonella infection can induce monocytes that disrupt pre-existing germinal center (GC) responses to a primary infection (or potentially vaccines) [... want %more?] → https://twitter.com/profshanecrotty/status/1508545384939155456 | 22:52 |
| Brainstorm | Updates for France: +29807 cases, +150 deaths since 23 hours ago — United Kingdom: +215179 cases, +217 deaths since 5 hours ago | 23:00 |
| Brainstorm | New from CIDRAP: Shanghai locks down as White House eyes 4th COVID-19 shots: Lisa Schnirring and Stephanie Soucheray | Staff Writers | CIDRAP News Mar 28, 2022 Also, President Biden's FY 2023 budget includes $10.7 billion in discretionary funds for the CDC. → https://www.cidrap.umn.edu/news-perspective/2022/03/shanghai-locks-down-white-house-eyes-4th-covid-19-shots | 23:30 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): It's important to turn the immune system toward Omicron since Omicron is now 100% of SARSCoV2. And this is slow in vaccinated or infected people due to earlier exposure to original strain. → https://twitter.com/michaelzlin/status/1508558514054041604 | 23:40 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): That's all the more reason to get started on Omicron boosters now.If a ship doesn't move much in the first few seconds after rudder deflection, the conclusion isn't that ships can't turn. It's that you should try to turn ships as early as [... want %more?] → https://twitter.com/michaelzlin/status/1508561174714982400 | 23:50 |
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