| Brainstorm | Updates for Guatemala: +1525 cases, +16 deaths, +10021 tests since 22 hours ago — Ethiopia: +966 cases since a day ago — Cabo Verde: +166 cases since a day ago — Mozambique: +150 cases, +2 deaths, +1016 tests since a day ago | 00:10 |
|---|---|---|
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): @jonasgahrstore @helse_og_omsorg @Folkehelseinst Neurological effects of COVID share similarities to neurodegenerative diseases where cytotoxic aggregated amyloid protein/peptides is a featurePeptides from SARSCoV2 self-assemble into amyloids that are [... want %more?] → https://twitter.com/GANyborg/status/1536832609870807045 | 00:14 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Immunity against Omicron is reduced (but better than infection-naive) in case of previous variant infection, not vaccination, with antibodies and T cells more specific for epitopes in the previous variant. pic.twitter.com/2E7aethN4v → https://twitter.com/Marc_Veld/status/1536840078223343616 | 00:42 |
| Brainstorm | Updates for Brazil: +44441 cases, +124 deaths since 21 hours ago — Turkey: +12995 cases, +31 deaths since 14 days ago — Kenya: +280 cases, +3105 tests since a day ago — Malawi: +27 cases, +613 tests since 2 days ago | 01:00 |
| Brainstorm | New from BBC Health: Cancer: High Street pharmacists to make referrals: Hundreds of pharmacists in England are being given powers to send patients for cancer scans and tests. → https://www.bbc.co.uk/news/health-61796834 | 01:29 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): COVID Conspiracy Beliefs Embraced by MillionsThis is truly sad, and not a Canadian issue: ~10% op people do belief in conspiracies regarding COVID-19 vaccines.abacusdata.ca/conspiracy-the… → https://twitter.com/Marc_Veld/status/1536854421065371648 | 01:39 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): It may be a little while until we have out the actual paper describing the Omicron BA.1/BA.2 deep mutational scanning linked at the top of this thread, but the experiments are basically done as described in this earlier work, and used monomeric ACE2: biorxiv.org/content/10.110… → https://twitter.com/jbloom_lab/status/1536857772653805568 | 01:58 |
| Brainstorm | Updates for Barbados: +131 cases, +786 tests since a day ago | 02:03 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): Finally, these Omicron RBD libraries as well as libraries for earlier variants (e.g., Delta, Beta, Wuhan-Hu-1, etc) are available in AddGene: addgene.org/pooled-library… → https://twitter.com/jbloom_lab/status/1536857776311263232 | 02:08 |
| LjL | %title https://www.reuters.com/world/china/china-bank-protest-stopped-by-health-codes-turning-red-depositors-say-2022-06-14/ | 02:40 |
| Brainstorm | LjL: From www.reuters.com: China bank protest stopped by health codes turning red, depositors say | Reuters | 02:40 |
| LjL | "it's only for your safety"... | 02:40 |
| LjL | "have this app, it will protect you" | 02:40 |
| LjL | sigh | 02:40 |
| Brainstorm | New from ##covid-19 Zotero group: China bank protest stopped by health codes turning red, depositors say: Type Newspaper Article Author Engen Tham URL https://www.reuters.com/world/china/china-bank-protest-stopped-by-health-codes-turning-red-depositors-say-2022-06-14/ Publication Reuters Date 2022-06-14T12:04:22Z [... want %more?] → https://www.zotero.org/groups/covid_links/items/S2954UUX | 02:46 |
| Brainstorm | Updates for Slovakia: +314 cases since 23 hours ago — Rwanda: +31 cases, +4773 tests since 4 hours ago | 02:59 |
| Brainstorm | New from ##covid-19 Zotero group: Fear of data misuse as health code turns red for Chinese bank protesters: Type Web Page URL https://www.scmp.com/news/china/science/article/3181635/chinese-health-code-turns-red-financial-victims-about-protest Date 2022-06-14T16:23:54+08:00 Accessed 2022-06-15 00:55:31 Language en [... want %more?] → https://www.zotero.org/groups/covid_links/items/55V3M9V3 | 03:05 |
| Brainstorm | Updates for Australia: +30136 cases, +44 deaths since 22 hours ago | 04:08 |
| Brainstorm | Updates for South Korea: +9423 cases, +9 deaths since 23 hours ago — Ghana: +711 cases, +3171 tests since 2 days ago | 05:05 |
| Brainstorm | Updates for Mexico: +8206 cases, +37 deaths, +21247 tests since a day ago — Bolivia: +493 cases since 23 hours ago | 06:07 |
| Brainstorm | Updates for Switzerland: +16614 cases since 13 hours ago — Japan: +13048 cases, +105745 tests since 11 hours ago — Germany: +37883 cases since 13 hours ago — Pakistan: +106 cases since a day ago | 07:04 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Analysis: Inhaled vaccine for COVID-19 — The pandemic accelerated decades of research leading to jab-free vaccine now in human testing – McMaster University → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vcn9pi/analysis_inhaled_vaccine_for_covid19_the_pandemic/ | 07:41 |
| Brainstorm | Updates for California, United States: +48190 cases, +80 deaths since 23 hours ago — North Rhine-Westphalia, Germany: +22598 cases, +27 deaths since 23 hours ago — Rio de Janeiro, Brazil: +10103 cases, +40 deaths since 23 hours ago — Victoria, Australia: +8484 cases, +18 deaths since 23 hours ago | 08:00 |
| Brainstorm | New from MedicineNet: (news): COVID Symptoms Rarely Rebound After Paxlovid Treatment: Study → http://www.medicinenet.com/script/main/art.asp | 08:37 |
| Brainstorm | Updates for Uzbekistan: +39 cases since 10 hours ago | 09:03 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | June 15, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/vcoi0o/daily_discussion_thread_june_15_2022/ | 09:05 |
| Brainstorm | Updates for Taiwan: +68931 cases, +143 deaths, +102227 tests since a day ago | 10:06 |
| Brainstorm | New from r/COVID19: COVID19: Immunogenicity and safety of coadministration of COVID-19 and influenza vaccination among healthcare workers → https://old.reddit.com/r/COVID19/comments/vcpt85/immunogenicity_and_safety_of_coadministration_of/ | 11:29 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): Infection with one variant of SARS-CoV-2 may not improve immunity/may reduce your immune response toward a different variant in the futuretwitter.com/dgurdasani1/st… → https://twitter.com/GANyborg/status/1537012359432216577 | 12:07 |
| Brainstorm | New from COVID on Twitter: (translated) Marc Veldhoen (@Marc_Veld): The article + authors are good. The conclusion of the account above is incorrect. Wt, Alpha or Delta infection confer less immunity, due to different epitopes, against omicron than 3x vax or Omicron itself. They give much more immunity than no [... want %more?] → https://twitter.com/Marc_Veld/status/1537013406351478784 | 12:17 |
| Brainstorm | New from COVID on Twitter: Gunhild Alvik Nyborg (@GANyborg): @Folkehelseinst @helse_og_omsorg @Helsedir @jonasgahrstore @ingvildkjerkol @camisto @Prebens @db_nyheter @svaar @astridmeland @dagsvanaes @GunnarKv @SteinarWestin @SteinarHolden @Tidsskriftet @Aftenposten @marierland @anspurk @F_Lund_Johansen @legeforeningen [... want %more?] → https://twitter.com/GANyborg/status/1537020205007884289 | 12:36 |
| Brainstorm | New from Reddit (test): Covid2019: Study on child hepatitis cases points to prior COVID infection, but experts say too soon to know → https://old.reddit.com/r/Covid2019/comments/vcritb/study_on_child_hepatitis_cases_points_to_prior/ | 12:46 |
| Brainstorm | Updates for Croatia: +547 cases, +2 deaths, +2182 tests since 20 hours ago | 13:01 |
| Brainstorm | New from BioNTech: Information on Dividend Payment and Tax Deduction: MAINZ, Germany, June 15, 2022 (GLOBE NEWSWIRE) — BioNTech SE (Nasdaq: BNTX, “BioNTech”) informs its shareholders that the dividend will be passed on to the investors of the [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/information-dividend-payment-and-tax-deduction | 13:05 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID Cases For 15JUN22 → https://old.reddit.com/r/nCoV/comments/vcsjz7/global_covid_cases_for_15jun22/ | 13:44 |
| Brainstorm | New from StatNews: Pharma: STAT+: FDA oversight of pharma manufacturing facilities plunges during the pandemic → https://www.statnews.com/pharmalot/2022/06/15/fda-covid19-manufacturing-inspections/ | 14:03 |
| Brainstorm | Updates for UAE: +1395 cases, +267653 tests since a day ago — Malta: +273 cases, +1321 tests since a day ago | 14:10 |
| Brainstorm | New from Reddit (test): Covid2019: Risk of blood clots in lung doubled for COVID survivors: US study → https://old.reddit.com/r/Covid2019/comments/vct0im/risk_of_blood_clots_in_lung_doubled_for_covid/ | 14:32 |
| Brainstorm | Updates for Indonesia: +1242 cases, +8 deaths since 22 hours ago | 15:00 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: FDA panel to review Covid shots for young children; Shionogi to license antibiotic to dozens of poor countries → https://www.statnews.com/pharmalot/2022/06/15/covid19-vaccines-fda-pfizer-moderna-antibiotics-shionogi-fda/ | 15:21 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunityVaccination was immunogenic in mild antibody deficiencies and phagocyte defects and in most patients with combined B- and T-cell immunodeficiency and [... want %more?] → https://twitter.com/Marc_Veld/status/1537063317100953601 | 15:31 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Comirnaty, Tozinameran,COVID-19 mRNA Vaccine (nucleoside modified), COVID-19 virus infection, Date of authorisation: 21/12/2020, Revision: 25, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/comirnaty | 15:40 |
| Brainstorm | New from r/COVID19: COVID19: Monoclonal Antibodies with Extended Half-Life to Prevent Covid-19 → https://old.reddit.com/r/COVID19/comments/vcuyhg/monoclonal_antibodies_with_extended_halflife_to/ | 15:50 |
| Brainstorm | Updates for Qatar: +513 cases since a day ago — Zambia: +317 cases, +1 deaths, +4805 tests since a day ago — Bangladesh: +232 cases, +5986 tests since a day ago | 16:03 |
| Brainstorm | New from Contagion Live: WHO Report: Origin of COVID-19 Remains to be Determined: The first report from WHO Scientific Advisory Group for the Origins of Novel Pathogens (SAGO) concedes SARS-CoV-2 source remains a mystery. → https://www.contagionlive.com/view/who-report-origin-of-covid-19-remains-to-be-determined | 16:10 |
| Brainstorm | New from BioNTech: Pfizer and BioNTech Provide Update on Rolling Submission to European Medicines Agency for a Potential Variant-Adapted Vaccine: NEW YORK and MAINZ, GERMANY, June 15, 2022 — Pfizer Inc. (NYSE: PFE, “Pfizer”) and BioNTech SE [... want %more?] → https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-provide-update-rolling-submission-european | 16:20 |
| Brainstorm | Updates for Greece: +9288 cases, +16 deaths since 23 hours ago — Kenya: +467 cases, +3728 tests since 15 hours ago — Iraq: +342 cases, +1 deaths since 22 hours ago | 16:59 |
| Brainstorm | New from WebMD: Life Span of Native Americans Fell by Almost 5 Years During Pandemic: Researchers report that the life expectancy of Native Americans plummeted by nearly five years as the new coronavirus raged across the country, another sign that the pandemic has [... want %more?] → https://www.webmd.com/lung/news/20220614/life-span-of-native-americans-fell-by-almost-5-years-during-pandemic | 17:00 |
| Brainstorm | New from ClinicalTrials.gov: (news): Safety and Immunogenicity of RVM-V001 in Healthy Individuals Previously Vaccinated With BNT162b2 and mRNA-1273 → https://clinicaltrials.gov/ct2/show/NCT05420077 | 17:09 |
| LjL | any opinions on whether drinking caffeine (usual amounts) with COVID is to be avoided? | 17:40 |
| LjL | (withdrawal is also not nice) | 17:40 |
| Brainstorm | New from ClinicalTrials.gov: (translated) TaiChi-DTx for Treating Long Covid Symptoms: Conditions: Tired; Dyspnea; Cognitive Impairment; Muscle Pain → https://clinicaltrials.gov/ct2/show/NCT05419219 | 17:48 |
| Brainstorm | New from ClinicalTrials.gov: (news): Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19 → https://clinicaltrials.gov/ct2/show/NCT05419128 | 18:08 |
| Brainstorm | New from r/COVID19: COVID19: Effectiveness of Ad26.COV2.S and BNT162b2 Vaccines against Omicron Variant in South Africa → https://old.reddit.com/r/COVID19/comments/vcy47l/effectiveness_of_ad26cov2s_and_bnt162b2_vaccines/ | 18:18 |
| Brainstorm | Updates for Italy: +32809 cases, +48 deaths, +195439 tests since a day ago | 19:05 |
| Brainstorm | New from r/Science: science: Participants who did not trust the COVID vaccine were more likely to believe in alternative facts (such as “All apples in the grocery stores are clones of each other, flavored and colored differently to increase sales”) and less likely to [... want %more?] → https://old.reddit.com/r/science/comments/vcyhd9/participants_who_did_not_trust_the_covid_vaccine/ | 19:07 |
| Brainstorm | New from Contagion Live: Routine Surveillance Details Rapid Spread of COVID-19 at Cornell University During Omicron Surge: High vaccination rates at Cornell University prevented severe disease during the Omicron surge of the COVID-19 pandemic [... want %more?] → https://www.contagionlive.com/view/routine-surveillance-details-rapid-spread-of-covid-19-at-cornell-university-during-omicron-surge | 19:16 |
| Brainstorm | New from Science Daily: COVID-19 on the brain: Neurological symptoms persist in majority of long-haulers: A new study describes the short- and long-term neurological symptoms of SARS-CoV-2 infection, and identifies a new group of COVID-19 long-haulers with advanced motor and cognitive symptoms. → https://www.sciencedaily.com/releases/2022/06/220615130820.htm | 19:36 |
| Brainstorm | New from r/COVID19: COVID19: Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study → https://old.reddit.com/r/COVID19/comments/vd0ma5/outcomes_of_the_sarscov2_omicron_b11529_variant/ | 20:05 |
| Brainstorm | Updates for Chile: +10648 cases, +16 deaths since a day ago — Canada: +22 deaths since 22 hours ago | 20:07 |
| Brainstorm | New from COVID19 Vaccine Tracker: (translated) valerie: AnGes: AG0301-COVID19 → https://covid19.trackvaccines.org/vaccines/3/ | 20:14 |
| Brainstorm | New from COVID19 Vaccine Tracker: valerie: AIM Vaccine: LVRNA009 → https://covid19.trackvaccines.org/vaccines/189/ | 20:25 |
| LjL | this is in italian unfortunately https://lab24.ilsole24ore.com/numeri-vaccini-italia-mondo/# but i find it rather unsettling... | 20:41 |
| LjL | it shows that even when looking at incidence, vaccinated people are as bad as unvaccinated ones, under some metrics | 20:41 |
| LjL | (cases, chiefly, but other metrics look worrying too) | 20:42 |
| Brainstorm | New from Politico: Fresh blow for Boris Johnson as ethics adviser quits amid Partygate fallout: Christopher Geidt recently suggested Johnson may have broken the ministerial code by getting a police fine for COVID rule breaches. → https://www.politico.eu/article/uk-boris-johnson-ethics-adviser-christopher-geidt-quits-amid-partygate/ | 20:45 |
| Brainstorm | Updates for Malaysia: +2320 cases, +5 deaths since 16 hours ago | 21:10 |
| Brainstorm | New from WebMD: Fauci Tests Positive for COVID-19: Anthony Fauci, MD, the chief medical officer to the White House, tested positive for COVID-19 on Wednesday. → https://www.webmd.com/lung/news/20220615/fauci-positive-covid | 21:46 |
| de-facto | %titel https://www.nature.com/articles/d41586-022-01526-0 | 21:53 |
| de-facto | %title https://www.nature.com/articles/d41586-022-01526-0 | 21:54 |
| Brainstorm | de-facto: From www.nature.com: COVID death tolls: scientists acknowledge errors in WHO estimates | 21:54 |
| de-facto | %title https://www.medrxiv.org/content/10.1101/2022.06.02.22275916v1 | 21:54 |
| Brainstorm | de-facto: From www.medrxiv.org: Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET | medRxiv | 21:54 |
| de-facto | LjL, the paper about neuroinflammation is really scary shit, it shows the neuroinflammation from long COVID 2 years after infection for patients with neurological symptoms by visualizing inflammation markers via PET while their brains did not show too much of abnormal MRI scans | 22:21 |
| de-facto | e.g. almost looks like MS on those scans | 22:22 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): And... FDA advisors give their advice of approval for Moderna.Gee, since the predetermined endpoint was antibody levels similar to adults, and this was achieved on 3/23 3 months ago, maybe they could have been asked that question [... want %more?] → https://twitter.com/michaelzlin/status/1537167226884997120 | 22:25 |
| LjL | de-facto, are these patients who had severe COVID? | 22:32 |
| de-facto | one was hospitalized but the woman was not (she recovered at home) | 22:32 |
| de-facto | still she had even worse neuroinflammation markers | 22:32 |
| LjL | damn, i see | 22:33 |
| LjL | uhm | 22:34 |
| de-facto | they show the spacial distribution of the resulting brain inflammation by PET | 22:34 |
| LjL | "Her medical history consisted of preexistent fibromyalgia" ← this is not nothing, though, is it? | 22:34 |
| LjL | i certainly can't read a PET scan | 22:34 |
| de-facto | well they show comparison images to control groups | 22:34 |
| Brainstorm | New from ##covid-19 Zotero group: Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET: Type Report Author Denise Visser Author Sandeep S. V. Golla Author Sander C. J. Verfaillie Author Emma M. Coomans Author Roos M. Rikken Author Elsmarieke M. van de Giessen Author Marijke E. den [... want %more?] → https://www.zotero.org/groups/covid_links/items/M4IQMI8I | 22:34 |
| de-facto | basically the long COVID brains are inflamed all over, while control groups not so much | 22:35 |
| de-facto | "Her numerous neurological symptoms started during the initial infection and her pre-existent fatigue worsened. Her symptoms remain present until this day, 15 months after infection." | 22:35 |
| de-facto | " During the acute phase of the infection, she was not hospitalized and did not need treatment." | 22:35 |
| de-facto | that was the first patient | 22:35 |
| de-facto | second patient | 22:35 |
| de-facto | "He was infected in March 2020 (PCR-confirmed). During the acute phase of SARS-CoV-2 infection, he was hospitalized on a nursing ward for a total of 15 days. After ten days, he was admitted to the intensive care unit (ICU) for one night due to respiratory problems. " | 22:35 |
| de-facto | "Although there has been some improvement, his symptoms remain present until this day, 24 months after infection" | 22:35 |
| de-facto | so unfortunately really long lasting issues | 22:35 |
| de-facto | " Long COVID patient 1 had verbal memory deficits, mildly impaired sustained attention, presence of severe fatigue and concentration problems, and severe functional impairmen" | 22:35 |
| de-facto | " Long COVID patient 2 had visuo-constructive deficits, fluctuating sustained attention, presence of fatigue, severe concentration problems, and severe functional impairment" | 22:36 |
| de-facto | they comment on the PET scans: | 22:36 |
| de-facto | "As can be visually appreciated, long COVID patient 1 had severely elevated [18 F]DPA-714 binding in all brain regions (Fig 2). Whole brain gray matter quantitative BPND (=k 3/k4) obtained from the 2T4k_VB model in long COVID patient 1 was increased by on average 121% relative to the healthy control subjects (Fig 2). " | 22:36 |
| de-facto | and patient 2: | 22:36 |
| de-facto | "Long COVID patient 2 also had elevated [18 F]DPA-714 binding (Fig 2), with an increase in whole brain gray matter BPND (=k3 /k4 ) obtained from the 2T4k_VB model by on average 79% relative to the healthy control subjects (Fig 2)." | 22:36 |
| de-facto | "In this study, we report widespread and large increases in [18 F]DPA-714 binding throughout the brain in the first two patients included in our in-vivo study of neuroinflammation. Although far from definitive, these findings are striking in extent and magnitude. As such, they implicate profound neuroinflammation in the pathophysiology of long COVID." | 22:36 |
| de-facto | "The extent of neuroinflammation in these patients with long COVID is remarkable. Whereas earlier post-mortem studies of acute COVID-19 patients have shown elevated neuroinflammation primarily in olfactory bulbs, medulla, brainstem and cerebellum, the current study suggests that the process of neuroinflammation may be more widespread in long COVID (5-7). " | 22:36 |
| de-facto | "Furthermore, as can be visually appreciated, we found high binding in the thalamus for both patients. This has also been reported in MS, using similar (TSPO) PET ligands (12). The thalamus is considered an important regulator, in relation to fatigue and cognitive functioning (13, 14) and may offer a clue towards the etiology of these symptoms in long COVID." | 22:37 |
| de-facto | "A recent study described cortical thinning and gray matter volume loss over time, as well as cognitive decline, in patients with long COVID (15). PET studies in MS have found that increased neuroinflammation is predictive of disease progression (16), suggesting a link between neuroinflammation and neurodegeneration on MRI. This may be relevant equally to long COVID." | 22:37 |
| de-facto | "The patients with long COVID in this study had widespread increases in neuroinflammation and substantial functional impairment, with only minimal abnormalities on MRI." | 22:37 |
| de-facto | "Although these are preliminary findings and the exact relation between neuroinflammation, functional impairment and longer term structural brain changes is not yet established, taken together, these findings do raise the question whether treatment with anti-inflammatory drugs could be beneficial" | 22:37 |
| de-facto | "Given the millions of people worldwide affected by this condition, the tremendous cost associated with it (to individuals and society) and the current, limited status of our knowledge, this is perhaps worthy of clinical investigation." | 22:37 |
| de-facto | well FUCK YEAH maybe we should have invested such things BEFORE deciding to "let it rip thorugh" our societies? | 22:38 |
| de-facto | how about establishing NOW how prevalent this issue is by screening representative parts of a population by PET scans and try to correlate their conditions with neuro-inflammation markers, maybe a blood test could be developed for testing for this condition? | 22:40 |
| de-facto | at least maybe some of the brain damage could be avoided by developing a treatment for the ongoing neuro-inflammation (maybe even some mRNA vaccination against auto-immune issues?) | 22:41 |
| de-facto | i mean something like this here: | 22:42 |
| de-facto | %title https://www.science.org/doi/full/10.1126/science.aay3638 | 22:42 |
| Brainstorm | de-facto: From www.science.org: A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis | 22:42 |
| de-facto | not sure if that can address the associated issues, but it would be worth investigating this i guess | 22:42 |
| LjL | i can't delve into this stuff. i'm already feeling scared all day every day for other reasons | 22:44 |
| de-facto | "Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes." | 22:45 |
| de-facto | "Krienke et al. designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigens." | 22:45 |
| de-facto | "In mouse models of MS, the vaccine delayed the onset and reduced the severity of established disease without showing overt symptoms of general immune suppression." | 22:45 |
| de-facto | although i should mention that its speculative if that could help with the above described long COVID brain inflammation, yet i think it really should be investigated | 22:46 |
| de-facto | this REALLY should be investigated, why is this not all over the news? its an issue that was ignored for far too long, investment into funding broad research in this field probably would pay off economically BIG time as it potentially could prevent more brain damage in the working class of a society | 22:50 |
| de-facto | instead it probably will get brushed away and ignored so that people would not get granted the recognition of their status as its probably long lasting | 22:52 |
| de-facto | yet instead of ignoring problems we should try to solve them, not only for economic reasons but also for helping those that suffer from long COVID | 22:52 |
| de-facto | plus there is a big revenue in such a market for any company that manages to develop something that is proven to help those patients | 22:53 |
| Brainstorm | New from WebMD: FDA Panel Votes Unanimously for COVID Shots for Youngest Kids: FDA advisors lent strong support to expand authorization of the Pfizer and Moderna shots in young children. → https://www.webmd.com/vaccines/covid-19-vaccine/news/20220615/fda-panel-votes-unanimously-for-covid-shots-for-youngest-kids | 22:53 |
| de-facto | yet people just keep naively repeating "COVID is over" and not wear masks anymore in public while we see the next fave BA.4/5 increasing with Rt ~ 1.3 and rising | 22:54 |
| LjL | you can't expect anyone to read this whole rant | 22:55 |
| LjL | if you're doing it for yourself, i guess be my guest, since this channel is dead | 22:55 |
| LjL | but if you want others to become aware of these looming issues, you need to editorialize your statements | 22:55 |
| de-facto | i guess all i am saying is that COVID is not over unfortunately it is increasing, e.g. in Germany | 22:56 |
| de-facto | and from going out i am not surprised, almost nobody is wearing masks anymore | 22:58 |
| de-facto | did people not learn in the last 2 years at all? | 22:58 |
| LjL | it's not about learning, it's about group behavior and who is able to lead the group :( | 22:59 |
| LjL | or successful memes, dTal might say | 22:59 |
| de-facto | well COVID is not going away by ignoring its presence as demonstrated many times by now | 23:00 |
| de-facto | but yeah people are not going to accept a meme that is incompatible with their convenience | 23:00 |
| de-facto | regardless if its reflecting actual independently verifiable observations form reality or not, rather people care about traveling in vacations and not having to deal with masks, even if that means they will risk brain damage | 23:01 |
| Brainstorm | Updates for Canada: +979 cases since 23 hours ago | 23:11 |
| LjL | what of this? | 23:29 |
| LjL | %print https://twitter.com/fitterhappierAJ/status/1536850268763086849 | 23:29 |
| Brainstorm | LjL, It says: Anthony J Leonardi, PhD, MS su Twitter: "You all need to understand this. The paper not only shows SARS Cov 2 mutating away from immunity But also old infections holding immunity back- immunity is worse off following another infection because of that earlier infection https://t.co/Z62HcMfy8G" | 23:29 |
| LjL | every once in a while, bringing original antigenic sin back? | 23:29 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): 3. 3-shot mRNA vs Omicron hospitalization had 77% (95% CI 71,82%) effectiveness in 21 US hospitals medrxiv.org/content/10.110… pic.twitter.com/anG7253CWr → https://twitter.com/EricTopol/status/1537185266032517120 | 23:32 |
| de-facto | and yet we still dont see vaccines with updated s-protein signatures available on the market? | 23:40 |
| LjL | if they aren't useful because we are already original sinned... | 23:41 |
| LjL | that's what Moderna found with their first attempt | 23:41 |
| LjL | second attempt, lately, they said something better, we'll see | 23:41 |
| de-facto | well if the alternative is a N-th shot with the over 2-year old Wuhan-Hu-1 S-protein signature... how would we ever know? | 23:43 |
| de-facto | instead we should already have a couple of new generations of vaccines on the market | 23:43 |
| de-facto | beta, delta, omicron, ... | 23:43 |
| LjL | we would know by in-vitro neutralization tests | 23:44 |
| LjL | you don't put a vaccine on the market (or even on human trial) if in vitro it does *worse* than the original strain vaccine | 23:45 |
| de-facto | what i mean is this: if the immune system repeatedly sees the same signature it will broaden the variety of antibodies a bit (e.g. first booster) but then only react with increase of antibody levels yet no broadening in their antigenic binding | 23:46 |
| de-facto | instead of artificially pinning the immune system with always repeating the stimulation with the same (outdated) antigenic signature we should try to *update* the immune system signatures by presenting it a up-to-date s-protein signature (after allowing it to contract from previous stimulation) | 23:48 |
| de-facto | yet if we keep holding it up and not even allow it to contract from outdated signatures, why would we assume that the immune system would not try to further refine its response on exactly that (outdated) signature then? | 23:49 |
| de-facto | it surely cant just "invent" an optimal response to the current antigenic version in circulation without even having a chance to see this antigen (e.g. by updated vaccination) | 23:50 |
| de-facto | also: pinning the antigenic spectrum of immune response in large parts of a population while promoting pathogen spread is probably one of the most effective methods to breed a evasive pathogen variant by natural selection | 23:51 |
| tortal | in swden we don't have a pandemic | 23:59 |
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