| Brainstorm | Updates for Bahrain: +73 cases (now 275130), +16935 tests (now 6.5 million) since 22 hours ago | 00:03 |
|---|---|---|
| nixonix | .title https://www.euronews.com/2021/09/28/romania-reports-new-record-for-covid-19-cases-amid-slow-vaccination-rates | 00:09 |
| Brainstorm | nixonix: From www.euronews.com: Romania reports new record for COVID-19 cases amid slow vaccination rates | Euronews | 00:09 |
| de-facto | i stay with my statement: we need to MASSIVELY ramp up PCR testing, make it *mandatory* for everyone twice a week | 00:11 |
| nixonix | .title https://www.washingtonpost.com/nation/2021/09/24/michigan-doctor-plea-unvaccinated/ https://archive.is/Jjl0i | 00:12 |
| Brainstorm | nixonix: From www.washingtonpost.com: - The Washington Post | 00:12 |
| nixonix | *Doctor who has lost over 100 patients to covid says some deny virus from their deathbeds: ‘I don’t believe you’ | 00:12 |
| nixonix | .title https://twitter.com/drdagly/status/1443615473459863569 start from the first post in the thread | 00:15 |
| Brainstorm | nixonix: From twitter.com: Darren Markland (@drdagly): "The journey of dying in the ICU from #COVID19 takes on average about a 6 weeks. I have seen what that does to families. Despite our resources and technology we can do [...] | 00:15 |
| de-facto | yeah its shocking how stupid people become from brainwashing in social media conspiracy bubbles | 00:22 |
| nixonix | its a cult. death cult | 00:23 |
| nixonix | .title https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/415378 sars1, not sars-cov-2 | 00:23 |
| Brainstorm | nixonix: From jamanetwork.com: Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome Survivors: Long-term Follow-up | Neurology | JAMA Internal Medicine | JAMA Network | 00:23 |
| nixonix | cult with active members trying to get other people, especially children, not to vaccinate but use ivermectin or something like that. and then more passive members, and then those that dont recruit other members but are just victims | 00:24 |
| nixonix | other than the last group i would put in the end of the list of those that get medical care. triage happens everywhere, not all old people even ever get in hospital in many countries, or get extra oxygen or anything | 00:25 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Clarification regarding term "reduction"Data in above post are adjusted odds ratios (aOR)Alpha: Pfizer 62%, AZ 38% reduction (R)Delta: Pfizer 37%, AZ 15% reductionThanks @JamesWard73, pointing out the difference (aOR v R)when the base probability of infection isn't very low → https://is.gd/4yzmxE | 00:26 |
| nixonix | then in hot spots, its hard to get in hospital when really needed | 00:27 |
| nixonix | .title https://www.nrtoday.com/news/health/coronavirus/covid-19-patient-dies-waiting-for-hospital-bed-in-douglas-county/article_78515493-2c1e-5b42-9bb2-e21ca8368da6.html this one got to hospital, but not in icu | 00:27 |
| Brainstorm | nixonix: From www.nrtoday.com: COVID-19 patient dies waiting for hospital bed in Douglas County | Coronavirus | nrtoday.com | 00:27 |
| de-facto | imho its also the fault of those algorithms of facebook et al, they select topics for suggestions only according to what people seem to be interested into, hence hiding all the contradictions they would encounter in real world (that would tell them what they dont want to know): its replacing reality with an artificially created topic bubble that detaches more and more from reality, suggesting to its members that this is status quo | 00:28 |
| de-facto | i will never register with facebook ever | 00:30 |
| de-facto | its a plague | 00:30 |
| nixonix | and it has spy scripts spread around (twitter has too, but it has tempted me to reg because some good information from experts) | 00:33 |
| nixonix | .title https://twitter.com/LauraMiers/status/1442980419494948865 nat geo article linked, and couple other ones in the same thread in the following posts, similar topic | 00:34 |
| Brainstorm | nixonix: From twitter.com: Laura Miers (@LauraMiers): "“This is something many people who suffered from COVID-19 discovered when they unexpectedly lost their senses of smell and taste. More recently, though, it has become [...] | 00:34 |
| Brainstorm | New from Reddit (test): nCoV: Covid Infections In Children Rise In UK Month After Schools Reopened | 01OCT21 → https://is.gd/bQniVf | 00:37 |
| nixonix | .title https://twitter.com/ShaneyWright/status/1434192222270988289 | 00:39 |
| Brainstorm | nixonix: From twitter.com: Shaney Wright (@ShaneyWright): "18 months with #LongCovid. Think I'll try to stop counting soon. A few symptoms have gone but are soon replaced. The neuro issues particularly have worsened over time. [...] | 00:39 |
| Brainstorm | Updates for United Kingdom: +34671 cases (now 7.9 million), +127 deaths (now 137170) since 22 hours ago | 00:41 |
| nixonix | .title https://www.theguardian.com/world/2021/mar/19/doctors-suggest-link-between-covid-19-and-diabetes More than 350 clinicians report suspicions of Covid-induced diabetes, both type 1 and type 2" - i thought it was just type 1 | 00:42 |
| Brainstorm | nixonix: From www.theguardian.com: Doctors suggest Covid-19 could cause diabetes | Coronavirus | The Guardian | 00:42 |
| nixonix | .title https://www.theguardian.com/society/2021/sep/29/covid-can-infect-cells-in-pancreas-that-make-insulin-research-shows?s=09 more recent | 00:43 |
| Brainstorm | nixonix: From www.theguardian.com: Covid can infect cells in pancreas that make insulin, research shows | Diabetes | The Guardian | 00:43 |
| de-facto | yeah i suspected that long time ago already | 00:43 |
| nixonix | .title https://twitter.com/DrEricDing/status/1435779145510834177 | 00:45 |
| Brainstorm | nixonix: From twitter.com: Eric Feigl-Ding (@DrEricDing): "⚠️“Who needs healthy kidneys anyways”—is what folks who ignore #LongCovid / don’t care about mild infections are de facto saying. New study (in a top nephrology [...] | 00:45 |
| nixonix | .title https://www.nature.com/articles/s41581-021-00487-3 | 00:46 |
| Brainstorm | nixonix: From www.nature.com: Long COVID and kidney disease | Nature Reviews Nephrology | 00:46 |
| Brainstorm | New from Reddit (test): nCoV: Covishield, China's Sinovac Approved By Australia Ahead Of Border Opening | 01OCT21 → https://is.gd/AYxIEs | 00:47 |
| de-facto | its silently taking away a lot of previously perfectly healthy individuals converting them to suffering from life long conditions probably, i really dont understand why this is not being stopped | 00:48 |
| nixonix | its selecting us by trait | 00:48 |
| de-facto | its destroying a whole healthy generation | 00:49 |
| nixonix | just hope that recent enough vax prevent vast majority of permanent damage. it for sure lessen it anyway. and reinfections, depends of different components of immunity and fading of them, and individual differencies and symptom severity affecting the development of plasma cells, germinal centers, memory cells etc, with varying levels of protection | 00:52 |
| nixonix | against the next one | 00:52 |
| nixonix | good cheap oral antivirals needed for those that test positive | 00:53 |
| de-facto | yeah of course it helps, but imho ending this only can be achieved my massively scaling up decentralized mandatory testing | 00:54 |
| de-facto | put a PCR in every supermarket, at every working place, at every school and every university | 00:54 |
| nixonix | but now the trend is not to test vaccinated, if the symptoms are mild. so it will be hard or impossible to prove you have long covid or long term or permanent damage caused by rona infection | 00:54 |
| de-facto | let people spit into a tiny sample tube and test them biweekly | 00:55 |
| de-facto | where would the pathogen hide then? | 00:55 |
| de-facto | testing in Germany will be stopped at Oct 10th on, because they will make people pay for the tests and dont support quarantine financially anymore | 00:56 |
| nixonix | reliable and accessible spit tests would be good (not on the level of pcr, so they shouldnt be reduce because using other types of tests) | 00:56 |
| de-facto | we will be completely blind | 00:56 |
| de-facto | hospitalizations are not reported recently enough, only showing half of the cases etc | 00:58 |
| de-facto | https://www-ndr-de.translate.goog/nachrichten/info/Hospitalisierungsrate-zeigt-nur-noch-die-Haelfte-der-Corona-Patienten,hospitalisierungsrate102.html?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=nui | 00:58 |
| Brainstorm | New from Reddit (test): Covid2019: Valneva starts recruitment of adolescents for Covid-19 vaccine trial in UK → https://is.gd/yTo0Lc | 00:58 |
| de-facto | "The hospitalization rate shows only half of the corona patients" | 00:58 |
| de-facto | "The hospitalization rate published by the Robert Koch Institute underestimates the number of Covid 19 sufferers in clinics more and more. In the coming autumn wave, the indicator could become virtually unusable." | 00:59 |
| de-facto | we urgently need MORE testing not less | 00:59 |
| nixonix | here our national health institute has pushed to ditch the restrictions, letting it burn through kids etc. saying things like there are other infections diseases, this rona thing gets too much attention | 00:59 |
| de-facto | we also need to test vaccinated etc | 00:59 |
| de-facto | and it should be made mandatory | 00:59 |
| de-facto | and of course free for all | 00:59 |
| de-facto | quarantine must be supported financially, people that isolate must be rewarded for protecting the community not the opposite | 01:00 |
| nixonix | and their health security chief that used to work with tegnell in sweden, said eg "i cant force people back to hobbies". now it seems some of them have suddenly become worried, because the same dude said "bar restrictions have possibly been removed too quick" | 01:00 |
| nixonix | they have reduced the testing, reporting etc, and positive percentege has increased the highest since spring 2020. daily deaths nearing last winter levels. mostly unvaccinated, so prob middle-aged lots of them now | 01:02 |
| nixonix | if that dude is suddenly worried, he either tries to secure his back before it gets really bad with those statements, or then they see it becoming really bad soon. their main goal anyway is quick mass infecting of kids before ema approves vax for them and they need to fight against vaccinating them... | 01:03 |
| de-facto | imho government has ONLY one job: R<1 | 01:05 |
| de-facto | everything else is secondary | 01:05 |
| Brainstorm | Updates for Bulgaria: +2091 cases (now 504253), +87 deaths (now 20969), +43415 tests (now 4.8 million) since 22 hours ago — Colombia: +1867 cases (now 5.0 million), +37 deaths (now 126336), +48358 tests (now 25.6 million) since 22 hours ago — Barbados: +228 cases (now 8609), +4 deaths (now 78), +4958 tests (now 320277) since 23 hours ago [... want %more?] | 01:06 |
| nixonix | lots of epidemic is going undercover now, when they refuse to test kids and quarantining others in the class is spotty. it remain hidden until they infect their parents, who are usually youngish middle age and mostly vaxed, so they dont want to test vaxed with mild symptoms | 01:06 |
| de-facto | so first of all we would need reliable representative screening for reproduction number, hence testing | 01:06 |
| de-facto | yes and if its tolerated to go under cover we will only notice once its too late, e.g. when real damage becomes apparent | 01:07 |
| nixonix | that would be against the plan of "awesome natural protection" (almost direct quote of one of our main vax chiefs) | 01:07 |
| de-facto | yet with tests we could react early and avoid such damage | 01:07 |
| nixonix | they are in a hurry before new research comes, and some of them might be reported in press, because its reported in many other countries | 01:08 |
| nixonix | our press covers their back currently, have done so since june | 01:08 |
| Brainstorm | New from Reddit (test): Covid2019: Will the Pandemic Really End Next Year? What the Experts Think: Experts say that although some of these predictions may prove accurate, factors like the United States reopening too soon this year and vaccine hesitancy could delay progress → https://is.gd/WPvB8s | 01:09 |
| nixonix | the most "free" press in the world (free for them, not free information for the public) | 01:09 |
| nixonix | .title https://www.cnbc.com/2021/09/27/covid-gottlieb-says-90percent-of-americans-may-have-immunity-post-delta.html | 01:11 |
| Brainstorm | nixonix: From www.cnbc.com: Covid: Gottlieb says 90% of Americans may have immunity post-delta | 01:11 |
| nixonix | .title https://www.insider.com/irish-man-encouraged-leave-hospital-anti-vaxxers-dies-covid-19-2021-9 | 01:17 |
| Brainstorm | nixonix: From www.insider.com: WATCH: Anti-Vaxxer Coaxes COVID-19 Man to Leave Hospital Who Later Died | 01:17 |
| Brainstorm | New from WebMD: Merck to Ask FDA for Emergency Approval of Its New Antiviral Pill for COVID: The drug maker claims clinical trials of its new antiviral pill molnupiravir shows the drug halved the risk of hospitalization or death when given to high-risk people shortly after infection with COVID-19. → https://is.gd/5mYj3t | 01:19 |
| nixonix | .title https://twitter.com/hjelle_brian/status/1443906269358682112 | 01:23 |
| Brainstorm | nixonix: From twitter.com: Brian Hjelle, virologist (@hjelle_brian): "It won't be ONE drug- it'll be a combo since virus can learn to resist any one drug." | nitter | 01:23 |
| de-facto | hmm the more specific to the virus the less side effects but the easier evasion, the broader antiviral the more side effects but the harder evasion by antigenic drift i would assume | 01:29 |
| nixonix | .title https://www.haaretz.com/israel-news/covid-booster-side-effects-lighter-than-after-first-two-shots-israeli-data-shows-1.10256884 they aspirate in israel, said somebody in a tweet. not sure if true, and not claiming if not aspiration is behind it or not | 01:29 |
| Brainstorm | nixonix: From www.haaretz.com: Only 12 children under 15 get myocarditis out of hundreds of thousands vaccinated in Israel - Israel News - Haaretz.com | 01:29 |
| de-facto | so imho targeting specific SARS-CoV-2 replication mechanisms, each of them with multiple independent drugs would probably mean the least side effects while minimizing evasion by antigenic drift, hence a cocktail of SARS-CoV-2 specific drigs and antibodies | 01:30 |
| Brainstorm | Updates for St. Kitts and Nevis: +47 cases (now 1965), +1033 tests (now 42068) since a day ago | 01:30 |
| nixonix | .title https://www.revyuh.com/news/lifestyle/health-and-fitness/study-reports-sharp-drop-in-antibody-levels-after-seven-months-for-double-vaccinated/ 85% ab reduction with pfizer in 7 months, and 80% with AZ in 3 months | 01:38 |
| Brainstorm | nixonix: From www.revyuh.com: Study reports sharp drop in antibody levels after seven months for double-vaccinated - Revyuh.com | 01:38 |
| nixonix | no information if they studied neut abs or binding, and which method used | 01:39 |
| de-facto | yell that would fit with 0,5^(7×30÷69) = 0,12 | 01:40 |
| nixonix | it may slow done somewhat in later months because bone marrow abs should be more stable (but titers low, and no information on neutralizing - and no information if its the same with vaccines as natural infection like it was in that bone marrow b-cell study - and if it depends on vax type) | 01:42 |
| nixonix | but that one az curve in that ons paper looked terrible | 01:43 |
| de-facto | yeah thats what i meant with sum of two exponentials, one with fast and one with slow half life | 01:43 |
| de-facto | btw afaik also clonal turnover in germinal centers happens after roughly 6 months, so that also may play a role | 01:43 |
| nixonix | yeah for circulating abs it might be the sum of two functions. but protection is way more complex, and not well understood. neut titers are the key vs infection though, along with innate immunity | 01:47 |
| nixonix | other adaptive response components come with delay, killer t-cells wane and are hampered by interferon inhibiting by sars2 (and orf8 mechanism of pulling mhc-I from cells surface), and helper t-cell activation by the same IFN thing, b-cells because of that etc. so circulating abs are important | 01:50 |
| nixonix | .title https://twitter.com/EricTopol/status/1420870547039158273 | 01:51 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "T cells were supposed to be the "on-demand" reserves to kick in after the normal decline of neutralizing antibody (nAb) levels, providing protracted protection. But several [...] | 01:51 |
| nixonix | and they might be the enemy. maybe because of SAG, maybe reasons they found in that lung study (whatever is behind the dysregulation of that subset, might be superantigen or something else) | 01:52 |
| de-facto | yes indeed since antibody affinity will mature and that will play a big role afaik | 01:52 |
| de-facto | so when measuring those ab titers it always depends on the antigen in use and how that correlates with live SARS-CoV-2 neutralization | 01:53 |
| nixonix | those come from gc memory b-cells, with delay. dont help vs infection, but symptom severity and clearing. if you have them (its possible that hospitalized patients while having high circulating ab titers have new germinal center formation disrupted, so good protection vs infection during the first few months, but possibly weak vs severe and after | 01:54 |
| nixonix | several months - if thats true) | 01:54 |
| de-facto | we really need more research in those mechanisms, how SARS-CoV-2 evades and sabotages immune system functionality and how that can be prevented, e.g. how to support the immune system by blocking SARS-CoV-2 ability to sabotage immune response | 01:56 |
| de-facto | are there such approaches? afaik so far the therapy approaches work not together with host immunity but in addition to it (hence possibly sometimes even against it) | 01:58 |
| de-facto | like what if a broad spectrum antiviral drug also affects some functions of the immune system by interfering with such generic mechanisms? | 01:59 |
| de-facto | what if drugs would target e.g. the interferon suppression mechanisms of SARS-CoV-2 or such? | 02:00 |
| de-facto | or those other NSPs that intend to suppress intra-follicular immune mechanisms or block functions inside the cell to have exclusive access to resources | 02:02 |
| nixonix | yuri said early on, that possibly some methods to support our immune response. sure there are those interferons, but they must be used very early | 02:06 |
| Brainstorm | Updates for Uruguay: +97 cases (now 389025), +1 deaths (now 6056), +17127 tests (now 3.6 million) since 23 hours ago — Paraguay: +30 cases (now 459997), +2 deaths (now 16200), +3463 tests (now 1.8 million) since 23 hours ago — Greenland: +8 cases (now 584), +678 tests (now 76491) since a day ago | 02:08 |
| nixonix | maybe something to prevent hostile immune cells making damage after virus is gone. like those t-cell depleting antibodies | 02:08 |
| de-facto | imho that would be the most promising approach, help the immune system to do the right thing instead of being manipulated by SARS-CoV-2 to do all the damage and allow it to replicate "under cover" etc | 02:10 |
| de-facto | but it needs to be done much much much faster than the progress we see right now | 02:12 |
| de-facto | trying to re-purpose old drugs, sure why not, but its not nearly enough | 02:12 |
| nixonix | there are probably lots of ideas that would work, but which ones will be studied and trialled, and in what timescale | 02:13 |
| nixonix | when the over 1.5 year old idea like eidd-2801 only now had their trial results (although they trialled it before with worse results, when selected patients were in too late stage i think) | 02:15 |
| nixonix | and huge pharma behind it | 02:16 |
| nixonix | .title https://twitter.com/EricTopol/status/1442673040916058115 | 02:17 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "Inconvenient truth #1 The waning of vaccine effectiveness vs symptomatic infections for both Pfizer and Moderna across all age 20+ groups, presented at @CDCgov Advisory [...] | 02:17 |
| nixonix | some shitty pictures without legend - "someone said green is COVID Classic, red is the Delta variant" | 02:19 |
| nixonix | didnt say in the pdf either | 02:19 |
| de-facto | .title https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-9-23/03-COVID-Oliver.pdf | 02:19 |
| Brainstorm | de-facto: From www.cdc.gov: PowerPoint Presentation (Godfrey, Monica (CDC/DDID/NCIRD/DVD)) | 02:19 |
| nixonix | whats ICATT | 02:21 |
| nixonix | other sources say faster waning for pfizer | 02:23 |
| nixonix | even previous infection for many wouldnt explain the difference, because not likely that something like over half would have had infection too | 02:26 |
| nixonix | .title https://twitter.com/EricTopol/status/1443967707544625153 | 02:30 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "Compare this with intravenous monoclonal antibodies in Phase 3 trial @NEJM this wk, a 71% reduction (4.6% vs 1.3%) hospitalization/death for outpatients w/ Covid < 7 days [...] | 02:30 |
| Brainstorm | Updates for Kazakhstan: +4729 deaths (now 15907) since 20 hours ago — Zimbabwe: +208 cases (now 131028), +1 deaths (now 4624), +3736 tests (now 1.4 million) since a day ago — Rwanda: +178 cases (now 97695), +3 deaths (now 1276), +23809 tests (now 2.8 million) since a day ago — Mozambique: +36 cases (now 150759), +1 deaths (now 1918), +3402 tests (now 907502) since a day ago | 02:33 |
| nixonix | .title https://twitter.com/EricTopol/status/1443941931109654529 | 02:33 |
| Brainstorm | nixonix: From twitter.com: Eric Topol (@EricTopol): "Substantial waning of immunity for both neutralizing antibodies and T cell response at 7 months after Pfizer vaccination [...] | 02:33 |
| nixonix | .title https://www.biorxiv.org/content/10.1101/2021.09.30.462488v1 | 02:33 |
| Brainstorm | nixonix: From www.biorxiv.org: Durability of immune responses to the BNT162b2 mRNA vaccine | bioRxiv | 02:33 |
| de-facto | .title https://www.nejm.org/doi/full/10.1056/NEJMoa2108163 | 02:34 |
| Brainstorm | de-facto: From www.nejm.org: REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19 | NEJM | 02:34 |
| de-facto | is that the one Trump got? | 02:34 |
| nixonix | i havent read the paper yet, and not sure if i understand well enough what those studied cytokines prove about the immune cells (and what they do not) | 02:34 |
| nixonix | regn-cov2 yeah | 02:35 |
| nixonix | one of the antibodies was partly compromised by delta, but seems to work anyways | 02:36 |
| nixonix | i think its the best on market currently. new ones are coming | 02:36 |
| de-facto | yeah the single one from Eli lilly was not working anymore | 02:37 |
| nixonix | funny how those antibodies can be found year or close after treatment. i wonder whats behind that mechanism, b-cells somehow copy that antibody i guess | 02:37 |
| nixonix | and also it could reduce vaccine induced immunity, if taken too soon afterwards | 02:38 |
| de-facto | or they were modified to stay longer? | 02:38 |
| nixonix | .title https://twitter.com/fitterhappierAJ/status/1438297304822321155 | 02:39 |
| Brainstorm | nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "The regeneron can attenuate the vaccine response, yes" | 42l - nitter | 02:39 |
| de-facto | yeah indeed, if they directly cover the antigenic epitopes the immune system may not learn how to do that | 02:39 |
| nixonix | i dont know if they have, but i wouldnt thing they remain for months. must be something else, ill try to find out some day | 02:39 |
| de-facto | make the cells bloom with spike, well if its directly covered with REGN-COV only few will be not covered and able to provoke the immune system to generate antibodies itself | 02:40 |
| nixonix | those pics in topols tweet and that paper, red circles were male, blue female, counter-intuitively | 02:42 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Portugal is the country with the highest fully vaccinated population in the world (86%) and 98% age 12+. No Covid restrictions. All Delta. Look what happens vs US with 30 per cent points lower fully vaccinated (56%)nytimes.com/2021/10/01/wor… @MarcSantoraNYT @RaphaelMinder pic.twitter.com/c2tFYBRDMM → https://is.gd/S6eNL4 | 02:43 |
| nixonix | this is just something i thought how it could go, not read so it might be wrong: infection or vaccination perhaps dissipates old germinal centers, leaving those follicular b-cells that have gone through somatic hypermutation and selection homeless... | 02:47 |
| nixonix | then infection or vaccination causes formation of new germinal centers. now if follicular dendritic cells there dont produce enough cytokines to effectively call also those improved, now homeless, b-cells there, they dont continue improving | 02:48 |
| de-facto | from the biorxiv paper about BNT162Bb | 02:49 |
| de-facto | "The estimated half-lives of binding and neutralizing antibody responses were 58 (95% Cl: 53.5 to 62.5) and 56 (95% Cl: 51 to 62) days, respectively." | 02:49 |
| de-facto | "In comparison, the half-life of live-virus neutralizing antibody response to mRNA1273 vaccination was 68 days (95% Cl: 61 to 75) as described in a previous study." | 02:49 |
| de-facto | "In contrast, the half-life of live-neutralizing antibody response was estimated as 150 days in COVID-19 infected individuals." | 02:49 |
| nixonix | but only those that are nearby or sense weak cytokines (IL-17A) populate them. also the same cytokine attracts follicular t-cells needed for selecting those with best affinity, and there might be no or not enough them for that | 02:49 |
| de-facto | i still think that has something to do with the duration between primer and booster | 02:50 |
| nixonix | some of that is what happens, some of that my own thinking how it could be hampered, like if vaccine doesnt iduce good cytokine profile for that | 02:50 |
| de-facto | maybe one bright day we will see a study that tries to correlate duration between primer and booster with antibody half life | 02:51 |
| nixonix | germinal center dynamics is a vast topic, and prob not that well understood | 02:51 |
| nixonix | yeah if its soon, new germinal centers and less time for maturing for those that were in the old ones (and dont end up continuing the maturation in new gc's - if not IL-17 producing dendritic cells - like mrna vaccines no IL-17, and with az only on half the subjects, so prob weak too) | 02:52 |
| nixonix | another mrna for producing the right adjuvant could be the solution | 02:53 |
| de-facto | heh thats a really good idea | 02:54 |
| nixonix | i told it here already awhile ago | 02:54 |
| nixonix | CpG perhaps could work | 02:54 |
| de-facto | also encoding multiple versions of s-protein may be a good idea, to broaden the immune response | 02:55 |
| nixonix | yeah, moderna had a candidate like that i think, ancient and SA variant | 02:55 |
| de-facto | haha ancient :D | 02:56 |
| nixonix | delta and SA variant could be a right call. the next variant could be some improved version of delta, or then 484K something, which is the most immune evasive mutation apparently | 02:57 |
| nixonix | i think they used ancient in some paper or press release, so not my idea | 02:57 |
| de-facto | yes the bivalent mRNA-1273.211 | 02:57 |
| de-facto | even Moderna themselves | 02:59 |
| de-facto | .title https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-it-has-shipped-variant-specific-vaccine/ | 02:59 |
| Brainstorm | de-facto: From investors.modernatx.com: Moderna Announces it has Shipped Variant-Specific Vaccine Candidate, mRNA-1273.351, to NIH for Clinical Study | Moderna, Inc. | 02:59 |
| nixonix | almost feeling like shooting my own shoulder some adjuvant after the 3rd shot. what would work if squalene (shark of synthetic) isnt available? | 02:59 |
| de-facto | "A multivalent booster candidate, mRNA-1273.211, which combines mRNA-1273, Moderna’s authorized vaccine against ancestral strains, and mRNA-1273.351 in a single vaccine at the 50 µg dose level and lower." | 02:59 |
| LjL | hi, i see i had a couple of highlights, i'll look at them later, i'm not feeling great, if there are things that definitely need to go to zotero please highlight me (i see apparently some drug that yuriwho had pointed out a while ago is making good steps forward?) | 02:59 |
| * LjL gets Brainstorm mail | 03:00 | |
| * Brainstorm starts to feel like a million LjL with some avertible fullness | 03:00 | |
| nixonix | yeah, it looks superb in that study. eidd-2801 | 03:00 |
| LjL | a million LjL, that sounds nightmarish | 03:00 |
| de-facto | i dont like it, but yeah its only my opinion | 03:01 |
| de-facto | its just remdesivir again, but this time orally | 03:01 |
| nixonix | you didnt like it last year, get over it (: | 03:01 |
| LjL | Molnupiravir on the other hand is something else, right? Merck's thing? | 03:02 |
| de-facto | yeah | 03:02 |
| de-facto | no thats the one | 03:02 |
| LjL | oh | 03:02 |
| nixonix | they have lots of names always | 03:02 |
| LjL | i definitely noticed a few headlines with "Merck's pill" but they didn't say more than that and i wasn't in the mood to read | 03:02 |
| nixonix | derek lowe blogged about it already | 03:02 |
| de-facto | btw apropos combining several antivirals | 03:02 |
| de-facto | .title https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00388-1/fulltext | 03:03 |
| Brainstorm | de-facto: From www.thelancet.com: The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model - EBioMedicine | 03:03 |
| LjL | de-facto, i have no opinions on this since i don't really know about it, but "the trial in early-stage coronavirus patients was stopped early due to efficacy" is usually something that's a very good thing i think | 03:03 |
| LjL | one of the few ways a trial can be stopped early that's good :P | 03:03 |
| nixonix | also regenerons mAb cocktail looked very good in that latest study | 03:03 |
| nixonix | not sure if they sold anything to europe. prob not to us, we are on bottom of all the lists | 03:04 |
| nixonix | or if they did, we didnt buy | 03:04 |
| de-facto | introducing a fatal mutation cascade with mimicing nucleosides with a pro-drug in a way that reminds of throwing a wrench in a gear | 03:04 |
| de-facto | in fact i hate that idea | 03:05 |
| LjL | de-facto, you're afraid of productive mutations? | 03:05 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study ( https://www.zotero.org/groups/covid_links/items/BF4AHBKX ) | 03:06 | |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Molnupiravir: Thor's Hammer Delivers ( https://www.zotero.org/groups/covid_links/items/FVQZKJJ6 ) | 03:06 | |
| de-facto | its just too broad imho, why would it not affect also functions outside SARS-CoV-2 | 03:06 |
| de-facto | it has one advantage over Remdesivir though, it can be given orally, hence potentially much easier via pill (in contrast to IV infusion) | 03:07 |
| nixonix | .title https://www.nejm.org/doi/full/10.1056/NEJMoa2109682 ah, they changed the name, no wonder i was confused. used to have 2 in the end | 03:08 |
| Brainstorm | nixonix: From www.nejm.org: Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 | NEJM | 03:08 |
| nixonix | that was the older paper, last week | 03:09 |
| de-facto | LjL have you seen the link https://www.cell.com/cell/fulltext/S0092-8674(21)00993-4 about "Delivering the message: How a novel technology enabled the rapid development of effective vaccines: Cell"? | 03:09 |
| LjL | yes de-facto, Brainstorm mailed it to me, i've just added it to zotero as an article | 03:10 |
| de-facto | its from TWIV | 03:10 |
| Brainstorm | Updates for Angola: +1493 cases (now 58076), +30 deaths (now 1567), +79802 tests (now 1.0 million) since a day ago | 03:10 |
| LjL | de-facto, what do you mean "from" TWIV? | 03:10 |
| de-facto | well in their links | 03:11 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Delivering the message: How a novel technology enabled the rapid development of effective vaccines ( https://www.zotero.org/groups/covid_links/items/2WAQD4BT ) | 03:11 | |
| LjL | i don't like zotero... completely | 03:11 |
| de-facto | .title https://www.microbe.tv/twiv/twiv-810/ | 03:11 |
| Brainstorm | de-facto: From www.microbe.tv: TWiV 810: Opening Pandora's box | 03:11 |
| LjL | in the web version i can sort by dated added but i can't figure out how to make two articles related. on the local version i can make them related but i can't sort them to make them easy to find at once | 03:12 |
| nixonix | .title https://old.reddit.com/r/COVID19/comments/pz3ad4/phase_1_placebocontrolled_trial_of_covivac_an/ | 03:17 |
| Brainstorm | nixonix: From old.reddit.com: Phase 1 Placebo-Controlled Trial of COVI-VAC, an Intranasal, Live Attenuated COVID-19 Vaccine : COVID19 | 03:17 |
| nixonix | they are already recycling vax names: "CoviVac Russia COVID-19 Vaccine is a whole-virion vaccine that uses viruses that have already been killed (inactivated). CoviVac-Russia vaccine includes all the elements of the virus. | 03:19 |
| LjL | wait what other vaccine is called CoviVac? | 03:20 |
| nixonix | the one above is covi-vac. not exactly the same but | 03:21 |
| LjL | oh lol i didn't realize you mentioned two different things :P | 03:23 |
| LjL | i need to take a paracetamol and go to bed | 03:23 |
| lastshell | valerian root | 03:23 |
| Brainstorm | New from r/WorldNews: worldnews: Chinese Media Blames Maine Lobster for Covid-19 → https://is.gd/Qkjhvl | 03:25 |
| LjL | guys help me one more bit so i don't waste time, is this EIDD-2801 / Molnupinavir trial's phase 3 interim results available as a paper, or is it just the press release for now? | 03:26 |
| LjL | i only have the press release and some articles about it so far | 03:26 |
| nixonix | more about telomeres - and connection to t-cells, whose expansion depends on telomere lengths (and differentiation reduces the amount of naive t-cells because its energy costing to maintain huge repertoire of differentiated t-cells and naive repertoire) | 03:30 |
| nixonix | .title https://www.medrxiv.org/content/10.1101/2021.05.19.21257474v2.full couple months old, but never seen before, somebody posted in reddit | 03:30 |
| Brainstorm | nixonix: From www.medrxiv.org: Short Telomeres and a T-Cell Shortfall in COVID-19: The Aging Effect | medRxiv | 03:30 |
| nixonix | "clearance of SARS-CoV-2 requires clonal expansion and differentiation of naïve T cells into SARS-CoV-2 antigen-specific effector/memory (henceforth memory) T cells (2,3,5). Short naïve T-cell telomeres might thus limit adaptive immunity against the virus even without infection-mediated T-cell lymphopenia | 03:30 |
| demon66 | !randquote | 03:31 |
| nixonix | also old people dont have (well) working thymus anymore | 03:31 |
| LjL | uhm one vaccine tracker that i used to have in the links (but removed because it had gone 404) is back in a USA-only form https://www.precisionvaccinations.com/vaccines/covid-19-vaccines-usa but it's interesting because it also covers non-vaccines, like molnupinavir, in some details https://www.precisionvaccinations.com/vaccines/molnupiravir-mk-4482-antiviral but unfortunately i see no RSS for it | 03:32 |
| LjL | demon66, what do you expect that to do? | 03:32 |
| demon66 | sorry the client does that | 03:32 |
| demon66 | I have a booster appt | 03:34 |
| LjL | lastshell, i drank some infusion that i think has valerian in it among other things, pretty mild though | 03:34 |
| Brainstorm | Updates for Gabon: +493 cases (now 30648), +4 deaths (now 190), +11839 tests (now 1.2 million) since a day ago — Guinea: +9 cases (now 30420), +1629 tests (now 557583) since a day ago | 03:35 |
| nixonix | is sars2 cytopathic? leonardi thinks its not, some dutch immunologist thinks it is (destroying infected cells, like producing virions till they rip apart, instead of mainly using them and virions leaving by exocytosis) | 03:46 |
| LjL | would it be considered cytopathic also if it didn't destroy them by ripping them apart with virions, but by other tricks like what's it called, making them fuse together and such? | 03:48 |
| LjL | <de-facto> its just too broad imho, why would it not affect also functions outside SARS-CoV-2 ← maybe it does, but it's targeted at people with moderate covid and at least one risk factor apparently, so i find it easy to think the benefits may outweigh the side effects | 03:49 |
| Raf[m] | i think in order for sars2 to be considered cytopathic, it would have to induce structural changes in the cytosol | 03:50 |
| Raf[m] | i think generally, this is not the case. what do you think? | 03:50 |
| LjL | Raf[m], from "Cytopathic effect" on Wikipedia: Common examples of CPE include rounding of the infected cell, fusion with adjacent cells to form syncytia, and the appearance of nuclear or cytoplasmic inclusion bodies.[3] | 03:52 |
| LjL | it's my understanding that SARS-COV-2 does cause fusion forming syncytia | 03:52 |
| LjL | or at least it's strongly suspected, right nixonix / de-facto? | 03:52 |
| nixonix | i was thinking the same (also messing them up with fusiogenicity), but there are some papers that think lysosomal exocytosis is its way to release virions | 03:56 |
| nixonix | maybe leonardi is closer to right, but apparently there is no consensus | 03:56 |
| Brainstorm | Updates for Mayotte: +49 cases (now 20323), +2 deaths (now 180) since 2 days ago — Curacao: +56 cases (now 16556), +1865 tests (now 280031) since a day ago — Mali: +36 cases (now 15255), +1 deaths (now 549), +1092 tests (now 420763) since a day ago | 04:00 |
| LjL | nixonix, but releasing virions and causing fusion are different things? | 04:03 |
| nixonix | well i have to look up definition of cytopathic... (leonardi has written about syncytia, so he is aware of cellular damage it causes, but said in their argument that it isnt cytophatic in his opinion) | 04:05 |
| LjL | well that's why i gave the definition of cytopathic from wikipedia! :P | 04:06 |
| LjL | it specifically says fusion with adjacent cells to form syncytia counts | 04:06 |
| nixonix | structural changes or ripping apart, something like that | 04:06 |
| nixonix | yeah but apart from cyncytia (however common it is, among infected cells) | 04:07 |
| nixonix | maybe its both mainly using gentle exocytosis when single cells, and messing them up when fused (and fracturing nucleuses and mitochondrias). they were arguing about pathological sides, the other immunologists thinking its about cell damage, leonardi that about immune cells, caused by SAG especially | 04:09 |
| nixonix | maybe ill link the arguing... | 04:09 |
| nixonix | .title https://twitter.com/Marc_Veld/status/1442552589594370051 | 04:10 |
| Brainstorm | nixonix: From twitter.com: Marc Veldhoen (@Marc_Veld): "That is also false. SARS-COV-2 is a new virus. Pathology is both due to overreaction in some, treated with steroids, and viral dissemination in others due to lack of prior [...] | 04:10 |
| LjL | "The virologists you listen to are incompetent" but of a strong statement | 04:14 |
| LjL | %ca sag | 04:15 |
| Brainstorm | LjL, That may also be called: superantigen | 04:15 |
| LjL | "Do you grasp that the superantigen's effect is to mimic novelty broadly?" ← what does this mean exactly? how do you "mimic novelty"? | 04:15 |
| LjL | also... is the superantigen just the S protein, or... i think i glanced over some recent mutation that may make it more super? Psomething mutation? | 04:16 |
| Brainstorm | New from https://covid19.specops.network : Add Merck press release about successful Molnupiravir trial: Courtesy nixonix. Adding to both Therapeutics and News section. There are probably also some good articles about it but that'll do for now. → https://is.gd/otRbi3 | 04:18 |
| nixonix | the quote means, superantigen (that it may have around furin site) wont be something that human immune response can learn not to get t-cells crazy. its about pattern recognizing (forgot which type, PAMP or the other one), prob against bacterial and other stuff instead of viral antigens, that evolution have induced | 04:19 |
| nixonix | DAMP was the other type | 04:21 |
| nixonix | "SARS-CoV-2 can also induce secretion of inflammatory cytokines and cell death by releasing pathogen-associated molecular patterns (PAMPs), such as viral RNA and damage-associated molecular patterns (DAMPs), including Adenosine triphosphate (ATP) and DeoxyriboNucleic Acid (DNA). It is also very likely that SARS-CoV-2 may antagonize interferon | 04:23 |
| nixonix | responses in various interferon signaling pathways | 04:23 |
| nixonix | not sure if superantigen pattern recognizing belongs to PAMP or DAMP. PAMP is mostly TRL receptors induced, DAMP have lots of receptors. have to read about superantigens more some day | 04:27 |
| nixonix | it maybe something else in t-cells | 04:27 |
| nixonix | around furin cleavage site, but i have no idea if mutations like P681R affects it, like making it less super or more | 04:31 |
| nixonix | PRRAR is polybasic cleavage site (double argins), RRRAR could be superbasic then... | 04:32 |
| nixonix | and its in different position than with those other coronaviruses. early on they said its not optimal, but actually its better. and even more with another argin | 04:34 |
| nixonix | (not optimal, as an evidence ccp didnt build it) | 04:34 |
| nixonix | *arginine | 04:35 |
| LjL | how can something so simple as a RRRAR pattern be enough to fool our immune system forever ;( | 04:36 |
| LjL | but yeah i probably was thinking of P681R, i saw it mentioned | 04:36 |
| LjL | this is the one i saw <Brainstorm> nixonix: From twitter.com: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): "P681R could be turning those "undetectable" viral infections into cases due to its ability to swallow T cells with Syncitia" | nitter | 04:37 |
| Brainstorm | Updates for New Caledonia: +191 cases (now 7619), +10 deaths (now 129) since a day ago — Djibouti: +59 cases (now 12870), +736 tests (now 222311) since a day ago — Canada: +4963 cases (now 1.6 million) since 12 hours ago | 04:37 |
| LjL | it sounded pretty "uh oh" | 04:37 |
| nixonix | funny you found that tweet, i just saw it again, and thought if i should paste it here | 04:38 |
| nixonix | oh i pasted it another day? | 04:39 |
| LjL | yes | 04:39 |
| LjL | and Leonardi's position seems to be that "thanks" to this superantigen (maybe even worse with P681R who knows), once our vaccine antibodies wane, we're fully vulnerable again, because if we meet the virus our immune system will go crazy again, instead of just remembering it and producing antibodies calmly, so we'll constantly need boosters? | 04:39 |
| nixonix | i dont know if leonardi is right about SEB SAG, but lots of things he said seem to be spot on. maybe its just me who is biased to be not too wishful thinker... | 04:40 |
| nixonix | if we clear the virus early enough, the possible superantigen has less chance to cause too much damage | 04:41 |
| nixonix | or otherwise dysregulated t-cells like in that lung study (i dont think they suggested the reason for the dysregulation, so it could be because of SAg) | 04:43 |
| LjL | i can't read comment sequences like this without feeling despair https://twitter.com/ErikRutins/status/1442555437195268105 | 04:43 |
| LjL | nixonix, do you think Marc Veldhoen is someone i should add to the twitter list (even if he disagrees with Leonardi)? | 04:44 |
| nixonix | new tweeter to me. if he is an immunologist that really tweets a lot about sars2, definately worth following. usually they dont do that much. iwasaki does at times | 04:46 |
| nixonix | a=i | 04:46 |
| LjL | Akiko Iwasaki? Seems to be mostly retweeting | 04:47 |
| LjL | Marc Veldhoen appears to tweet a lot mostly about COVID, maybe even too much | 04:48 |
| nixonix | yeah, she had a good thread on their mouse study recently | 04:50 |
| nixonix | .title https://twitter.com/VirusesImmunity/status/1442891098968535046 | 04:50 |
| Brainstorm | nixonix: From twitter.com: Prof. Akiko Iwasaki (@VirusesImmunity): "This is a theoretical possibility but we are seeing good boosting in antibody and T cell responses with each shot so far against the VOC like delta." | nitter | 04:50 |
| LjL | oh well, i'm adding both of them for now | 04:50 |
| nixonix | mostly just retweets and congratulations and stuff. and another immunologist tweets mostly about crypto currencies... | 04:51 |
| Brainstorm | Updates for St. Vin. and Gren.: +55 cases (now 3563), +5 deaths (now 26), +356 tests (now 77176) since a day ago — Guinea-Bissau: +3 cases (now 6110), +348 tests (now 98330) since a day ago | 05:02 |
| Brainstorm | New from r/WorldNews: worldnews: U.S. reaches 700,000 deaths from COVID-19 as Delta variant hits unvaccinated - National | Globalnews.ca → https://is.gd/8SHf1Z | 05:33 |
| Brainstorm | Updates for South Korea: +2247 cases (now 316020), +7 deaths (now 2504), +48473 tests (now 14.6 million) since a day ago — Belgium: +2243 cases (now 1.2 million), +10 deaths (now 25612) since a day ago — Panama: +225 cases (now 467338), +2 deaths (now 7230), +8001 tests (now 3.9 million) since a day ago — Netherlands: +98 cases (now 2.0 million) since 12 hours ago | 05:39 |
| Brainstorm | Updates for Peru: +962 cases (now 2.2 million), +28 deaths (now 199423), +45694 tests (now 18.0 million) since a day ago — France: +5048 cases (now 7.1 million) since 9 hours ago — United Kingdom: +95 cases (now 7.9 million) since 5 hours ago | 06:29 |
| Brainstorm | New from r/WorldNews: worldnews: Singapore hits highest daily number of Covid-19 cases since the start of the pandemic → https://is.gd/RkelDX | 06:46 |
| Brainstorm | Updates for India: +22545 cases (now 33.8 million), +1517652 tests (now 572.0 million) since 14 hours ago | 07:06 |
| Brainstorm | New from The Indian Express: World: California pushes 1st US Covid vaccine mandate for school children → https://is.gd/pd4qvr | 07:07 |
| sdfgsdfg | any bad news ? | 07:22 |
| sdfgsdfg | everything looks peachy in general | 07:22 |
| sdfgsdfg | on a side note.... hoooly **** apparently almost 1 million people died in total in us. That's crazy | 07:24 |
| Brainstorm | Updates for Negeri Sembilan, Malaysia: +197 cases (now 97442) since 23 hours ago — Northwest Territories, Canada: +95 cases (now 1154) since a day ago — Lombardy, Italy: +381 cases (now 884125), +8 deaths (now 34049) since 23 hours ago — Hunan, China: +4 cases (now 1187) since 23 hours ago | 07:31 |
| Brainstorm | Updates for Kyrgyzstan: +72 cases (now 178680), +3478 tests (now 1.7 million) since 23 hours ago | 08:08 |
| Brainstorm | New from Science-Based Medicine: A Modest Proposal: Close Pediatric Cancer Hospitals: What if people thought about pediatric cancer the way they do pediatric COVID-19? A satirical argument to stop treating children for cancer. The post first appeared on Science-Based Medicine . → https://is.gd/TkeDlH | 08:32 |
| Brainstorm | Updates for Germany: +7788 cases (now 4.3 million), +4 deaths (now 94254) since 15 hours ago | 08:33 |
| Brainstorm | New from The Indian Express: World: FDA advisers to review COVID-19 shots for young kids, boosters this month → https://is.gd/4uyumJ | 08:43 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | October 02, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://is.gd/OtY5Bu | 09:05 |
| Brainstorm | New from The Indian Express: World: Covid cases are falling, but US on the brink of 700,000 dead → https://is.gd/4Fg4Xd | 09:15 |
| Brainstorm | Updates for Georgia: +1826 cases (now 616589), +29 deaths (now 9005), +51248 tests (now 9.0 million) since a day ago — Armenia: +1152 cases (now 263783), +15 deaths (now 5354), +9656 tests (now 1.7 million) since a day ago | 09:35 |
| Brainstorm | New from COVID tweets: Marc Veldhoen (@Marc_Veld): The burden of COVID-19 is far higher in developing countries than in high-income countries, reflecting a combination of elevated transmission to middle-aged and older adults as well as limited access to adequate healthcare.medrxiv.org/content/10.110… → https://is.gd/MzfJfL | 09:57 |
| Brainstorm | Updates for New Caledonia: +313 cases (now 7932), +13 deaths (now 142) since 5 hours ago | 10:00 |
| Brainstorm | New from The Indian Express: World: Merck says it has the first antiviral pill found to Be effective against Covid-19 → https://is.gd/wbmQAq | 10:08 |
| Brainstorm | New from COVID tweets: Marc Veldhoen (@Marc_Veld): Portugal has nearly run out of people to vaccinate. What comes next?smh.com.au/world/europe/p… → https://is.gd/5lTspx | 10:19 |
| Brainstorm | Updates for Estonia: +742 cases (now 157728), +6193 tests (now 1.9 million) since a day ago | 10:38 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): The Daily Mail publishing a sober and fairly technical critique of an article published in a specialised scientific journal comes as a bit of a surprise. Interesting times...Controversial analysis calls for kids to get two Covid jab doses mol.im/a/10041743 via @MailOnline → https://is.gd/y2WXhm | 10:40 |
| Brainstorm | New from The Indian Express: World: India going to play most important role in bringing Covid pandemic to end: US-AID administrator → https://is.gd/8CKqzM | 11:01 |
| de-facto[m] | .title https://www.pnas.org/content/117/41/25254 | 11:38 |
| Brainstorm | de-facto[m]: From www.pnas.org: Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation | PNAS | 11:38 |
| Brainstorm | Updates for Poland: +1344 cases (now 2.9 million), +23 deaths (now 75689), +42312 tests (now 21.0 million) since 23 hours ago — Netherlands: +114 cases (now 2.0 million) since 18 hours ago | 11:40 |
| de-facto[m] | .title https://www.nature.com/articles/s41577-021-00502-5 | 11:41 |
| Brainstorm | de-facto[m]: From www.nature.com: Super(antigen) target for SARS-CoV-2 | Nature Reviews Immunology | 11:41 |
| de-facto[m] | .title https://www.cell.com/structure/fulltext/S0969-2126(21)00121-0 | 11:42 |
| Brainstorm | de-facto[m]: From www.cell.com: Home: Cell Press | 11:43 |
| de-facto[m] | A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro | 11:43 |
| Brainstorm | New from COVID tweets: Tom Wenseleers (@TWenseleers): Age-specific infection fatality rate of Covid is 1.3-2.5x higher in developing countries than in high income countries. twitter.com/GidMK/status/1… → https://is.gd/jyIy2o | 11:53 |
| Brainstorm | Updates for Latvia: +1190 cases (now 160608), +10 deaths (now 2731), +20656 tests (now 4.4 million) since a day ago | 12:05 |
| Brainstorm | New from BBC Health: Covid: Care home staff should get the jab or another job - Javid: The health secretary says he will not delay the November deadline for workers to be fully vaccinated. → https://is.gd/9qubvD | 12:46 |
| Brainstorm | Updates for UAE: +256 cases (now 736524), +305131 tests (now 84.6 million) since a day ago | 13:07 |
| Brainstorm | Updates for Indonesia: +1414 cases (now 4.2 million), +89 deaths (now 142115), +236653 tests (now 39.6 million) since a day ago | 13:32 |
| Brainstorm | Updates for Romania: +12590 cases (now 1.3 million), +184 deaths (now 37394), +78982 tests (now 13.0 million) since a day ago — Austria: +1416 cases (now 746380), +7 deaths (now 11021), +225990 tests (now 87.7 million) since a day ago — Nepal: +659 cases (now 796618), +9 deaths (now 11157), +5598 tests (now 4.2 million) since a day ago [... want %more?] | 14:09 |
| Brainstorm | New from The Indian Express: World: White House pushes US airlines to mandate vaccines for staff by Dec 8 → https://is.gd/VkzUpn | 14:21 |
| Brainstorm | Updates for Slovakia: +1293 cases (now 415016), +11 deaths (now 12660), +11203 tests (now 3.6 million) since a day ago — Gibraltar: +11 cases (now 5566), +1695 tests (now 363191) since 12 hours ago — United Kingdom: +100 cases (now 7.9 million) since 13 hours ago | 14:34 |
| Brainstorm | Updates for Uganda: +115 cases (now 123857), +4163 tests (now 1.7 million) since a day ago — Zambia: +28 cases (now 209142), +5596 tests (now 2.5 million) since 17 hours ago — Denmark: +4 deaths (now 2663), +71052 tests (now 83.8 million) since 22 hours ago | 14:59 |
| Brainstorm | New from Reddit (test): CoronavirusUK: Unvaccinated care workers should get another job, says Javid → https://is.gd/jaLdzv | 15:03 |
| Brainstorm | New from Contagion Live: Understanding Long-Term Pediatric SARS-CoV-2 Antibodies: A new study from IDWeek showed most observed children previously infected with SARS-CoV-2 retained antibodies over 6 months. → https://is.gd/IOGEYW | 15:14 |
| Brainstorm | New from r/Science: science: Trust in social media linked to heightened susceptibility to COVID-19 conspiracy theories → https://is.gd/WyBWJC | 15:25 |
| Brainstorm | New from r/WorldNews: worldnews: Heart inflammation rates higher after Moderna vaccine - Canada data → https://is.gd/0H6mFs | 15:36 |
| Brainstorm | Updates for Bangladesh: +589 cases (now 1.6 million), +24 deaths (now 27555), +17283 tests (now 9.8 million) since 23 hours ago | 15:36 |
| Brainstorm | Updates for Belarus: +1998 cases (now 542077), +15 deaths (now 4174), +35647 tests (now 8.6 million) since 23 hours ago — Laos: +606 cases (now 24916), +1 deaths (now 21), +6709 tests (now 508315) since a day ago — Saudi Arabia: +42 cases (now 547221), +3 deaths (now 8722), +47266 tests (now 29.0 million) since 23 hours ago | 16:01 |
| Brainstorm | New from COVID tweets: Prof. Akiko Iwasaki (@VirusesImmunity): With input from @Survivor_Corps and @patientled, we are studying the impact of COVID vaccines on #longCOVID symptoms and correlating the changes in the immune responses to symptom changes. Led by @DaisySMassey @hmkyale (7/)medrxiv.org/content/10.110… → https://is.gd/zPc1YQ | 16:30 |
| Brainstorm | Updates for Qatar: +99 cases (now 236834), +5419 tests (now 2.7 million) since a day ago | 16:38 |
| Brainstorm | New from r/WorldNews: worldnews: A scientist’s decades of research paid off when vaccines were needed. → https://is.gd/ylTQ6S | 16:40 |
| Brainstorm | New from COVID tweets: Charlie Weller (@DrCharlieWeller): Adding to the evidence base on the positive impact of #COVID vaccines on #LongCovid Read @VirusesImmunity 🧵👇🏻Bringing some much needed light on such a bleak ☔️ day twitter.com/virusesimmunit… → https://is.gd/PArpSd | 16:51 |
| Brainstorm | Updates for India: +18308 cases (now 33.8 million), +132 deaths (now 448636) since 22 hours ago | 17:09 |
| Brainstorm | New from Contagion Live: HIV Mental Health, Substance Risk During the Pandemic: A conversation in consideration of the high-risk psychosocial comorbidities the aging HIV population may face through COVID-19. → https://is.gd/Q2ssZC | 17:12 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): In the United States, 400,000 covid deaths (of 700K) occurred after the 1st vaccines were given. Almost all of the last 200,00 deaths would have been prevented if these people had been vaccinatednytimes.com/2021/10/01/us/… @LaurenLeatherby pic.twitter.com/Y4C1ksOB5b → https://is.gd/gNu34P | 17:22 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The unnecessary loss of lives of young people (age 25-54) were the highest for the pandemic in recent weeks, at a time when vaccines were abundantly available to all pic.twitter.com/8FjH2eJCw3 → https://is.gd/xCdABS | 17:33 |
| Brainstorm | Updates for Greece: +1798 cases (now 660166), +29 deaths (now 14889), +180977 tests (now 20.5 million) since 23 hours ago — Netherlands: +1772 cases (now 2.0 million), +5 deaths (now 18595) since 23 hours ago — Chile: +813 cases (now 1.7 million), +8 deaths (now 37484), +137556 tests (now 21.9 million) since 22 hours ago [... want %more?] | 17:34 |
| Brainstorm | New from NPR: American, Alaska Airlines and JetBlue will require their employees to be vaccinated: The three airlines are joining United in mandating that workers be vaccinated against COVID-19, as the Biden administration steps up pressure on major U.S. carriers to require the shots. → https://is.gd/WP4qve | 17:55 |
| Brainstorm | Updates for Italy: +3309 cases (now 4.7 million), +25 deaths (now 130998), +355896 tests (now 93.1 million) since 23 hours ago | 17:59 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): For an astute perspective of this study for vaccination potential of treating/reducing the toll of #LongCovid, an outstanding thread by @VirusesImmunity twitter.com/VirusesImmunit… → https://is.gd/ZPyuAj | 18:48 |
| Brainstorm | New from r/Science: science: Diabetes patients more likely to die with COVID-19 if they're male: studies → https://is.gd/MluzLb | 18:58 |
| Brainstorm | New from Reddit (test): nCoV: Global COVID-19 deaths hit 5 million as Delta variant sweeps the world → https://is.gd/bzj5II | 19:09 |
| Brainstorm | New from Johnson&Johnson: Innovation: Janssen Announces Phase 2b Data Demonstrating its Investigational RSV Adult Vaccine Provided 80% Protection against Lower Respiratory Infections in Older Adults → https://is.gd/W4qpBc | 19:20 |
| Brainstorm | Updates for United Kingdom: +29500 cases (now 7.9 million), +122 deaths (now 137292) since 18 hours ago — Dominican Rep.: +660 cases (now 360257), +6 deaths (now 4055), +4961 tests (now 2.1 million) since a day ago | 19:32 |
| Brainstorm | New from Reddit (test): nCoV: I found the Inner Strength to keep pursuing my Passion after I discovered the Dunning Kruger Effect → https://is.gd/lnbqZH | 19:52 |
| xiuoxiu | dudes, people are using cheap tricks in arguments, like accusing of dunning kruger or "doubling down" on something, instead of arguing about the actual issue. why is that? does it matter who "wins" an internet argument between two unknown persons | 20:01 |
| LjL | hell yeah | 20:11 |
| LjL | it's the only thing that matters on the internet! | 20:11 |
| Brainstorm | New from Contagion Live: us: CYPRESS Trial: RSV Vaccine for Older Adults Elicits Robust Immune Response → https://is.gd/l9rAM2 | 20:24 |
| nana | so get the booster, if not old ? | 20:26 |
| LjL | i'd say especially if old | 20:35 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): We will soon have all the tools needed to end the pandemic, if only we had them🌍and were fully used✓ vaccines✓ masks + mitigation measures (distancing, ventilation, etc)✓ pill ("M-pack"+ others) & monoclonal Abs as backup✓ rapid tests (more important than ever w/a pill) → https://is.gd/fvrapF | 20:45 |
| xiuoxiu | that dutch immunologist thinks there will be lasting and robust systemic immunity that with frequent upper airways only reinfections make the epidemic endemic and mild | 20:55 |
| xiuoxiu | so we need more reinfection and breakthrough hospitalization data, age etc adjusted, to see if he is right | 20:57 |
| Brainstorm | Updates for Germany: +22 deaths (now 94272) since 23 hours ago | 20:59 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): "While science may aspire to stand on the shoulders of giants, vaccine inequity has trampled on the hopes of the vulnerable"—@AdamJKucharski in his review of @d_spiegel & @anthonybmasters COVID by Numbers new bookthelancet.com/journals/lance… @TheLancet pic.twitter.com/yJyoELJHJg → https://is.gd/sXR7sl | 21:07 |
| xiuoxiu | .title https://www.google.com/url?q=https://oklahoma.gov/content/dam/ok/en/covid19/documents/weekly-epi-report/2021.09.29 Weekly Epi Report.pdf spaces in the url, but seems to work | 21:17 |
| Brainstorm | xiuoxiu: From www.google.com: Avviso di reindirizzamento | 21:17 |
| xiuoxiu | .title https://oklahoma.gov/content/dam/ok/en/covid19/documents/weekly-epi-report/2021.09.29 Weekly Epi Report.pdf | 21:17 |
| Brainstorm | xiuoxiu, the URL could not be loaded | 21:17 |
| xiuoxiu | try this https://oklahoma.gov/content/dam/ok/en/covid19/documents/weekly-epi-report/2021.09.29 Weekly Epi Report.pdf | 21:17 |
| xiuoxiu | inside "": "https://oklahoma.gov/content/dam/ok/en/covid19/documents/weekly-epi-report/2021.09.29 Weekly Epi Report.pdf" | 21:18 |
| xiuoxiu | damn! try copy pasting the pieces, with spaces | 21:18 |
| xiuoxiu | for pfizer (vaccinated, number of breakthrough cases, breakthroughs per 100k, hospitalizations, deaths): 997,514 5,938 595.28 371 75 | 21:20 |
| specing | Where are the delta-specific vaccines? | 21:25 |
| specing | We've had delta for what, 5 months now? | 21:26 |
| nixonix | those oklahoma breakthroughs are probably over 90% delta, looking at the shape of their curve in oklahoma | 21:26 |
| nana | LjL: how about age 40 , without comorbidity or high risk job | 21:27 |
| Brainstorm | New from r/WorldNews: worldnews: Nanoparticle Vaccine → https://is.gd/s9Jvln | 21:28 |
| LjL | nana, based on my opinions on what i've read about the need for a booster, i believe a booster will be useful for everybody who got vaccinated in the first place, but for the situation you mention, a booster may not be *urgent*. however it seems likely that a booster will be needed for everyone after at most a year or so since vaccination. anyway each country will have their own policies and priorities and there are not necessarily "right" ones and "wrong" ones, | 21:28 |
| LjL | they all have to balance a multitude of factors | 21:28 |
| LjL | specing, we've had Beta for much longer than 5 months (okay, to be fair we mostly don't have it, luckily, but it was kind of expected to become widespread) and the vaccines for *that* are still in the pipeline... | 21:29 |
| LjL | nixonix, that's basically 6% of vaccinated people who got infected needing hospitalization in oklahoma, so pretty much the same percentage (5.7%) as infections in general? | 21:33 |
| LjL | yes i know, vaccinated people have a lower probability of getting infected in the first place. but it seems the oft-cited phrase "... and vaccinated people are much less likely to get severe disease" may not be so true | 21:33 |
| LjL | also, whoever got J&J, get a booster if you can thank you very much ;( | 21:34 |
| LjL | interesting that they compare breakthroughs to reinfections directly | 21:35 |
| nixonix | different adjustments needed, like those with severe symptoms are way more likely to get tested. asymptomatic usually go unnoticed, mild often dont bother to get tested, age groups etc. as a raw data the protection looks very strong vs severe, though | 21:36 |
| Brainstorm | Updates for France: +5261 cases (now 7.1 million) since 15 hours ago | 21:37 |
| nixonix | deaths may not get all in hospital, they might die in home or care home etc, so theres prob partial overlapping | 21:37 |
| nixonix | median time for those hospitalized when they got the 2nd dose was around apr 21 (i considered delays from infection to hospital admission). but those ending in hospital were more likely older, that got vaxed earlier | 21:39 |
| nixonix | damn, it wasnt weekly stats as was when i estimated these the last time, but total. so forget the last one | 21:40 |
| -RSSBot[LjLmatrix- Zotero / COVID links Group / Top-Level Items: Weekly Epidemiology and Surveillance Report ( https://www.zotero.org/groups/covid_links/items/AUSN8IJ3 ) | 21:41 | |
| nixonix | so it was around apr 18, the median time (didnt change much), but because they were older most of time, maybe mid march. median time from 2nd dose should be around 4.5 months considering they were usually older | 21:46 |
| nixonix | so whats the hospitalization rate for unvaxed, roughly? they are skewed differently, old ppl get vaxed more often, and they dont have risky contacts as often | 21:49 |
| nixonix | and case identifying rates different for vaxed and unvaxed, and between age groups, urbanization etc | 21:50 |
| LjL | i don't know, you've successfully deconstructed any conclusion i can make directly from that data :P | 21:50 |
| nana | yeah, we'll see if they give me the 'booster' then on wed my appt | 21:51 |
| nixonix | if we dont have good adjusted data on breakthrough hospitalizations, we cant say if that assumption of that dutch immunologist is correct or not (with delta, even forgetting possibility of more immune evasive variants to emerge) | 21:55 |
| nixonix | did they ever make good analysis on that israeli data? which had ve vs hospitalization down to 80% in under 5 months - but without correcting for age etc | 21:56 |
| nixonix | who took jnj in usa? more old or young people? | 21:59 |
| Brainstorm | Updates for Namibia: +76 cases (now 127756), +1 deaths (now 3515), +1986 tests (now 707489) since a day ago | 22:02 |
| nixonix | moderna, pfizer, jnj breakthrough hospitalizations/cases: 5.8%, 6.25%, 7% | 22:02 |
| lastshell | nixonix for what I know they recommend jnj to young generation but they distribute to everyone | 22:09 |
| nixonix | if we just estimated like in 4.5 months VE vs infection would be something like 60% with pfizer, then multiply that with hospitalization/case rate of 6.25%, we could compare the result to unvaxed ppls hosp rate, but too many things adjustments missing, shares of hidden cases different | 22:10 |
| lastshell | when i was in WA i wanted that one but they give to first responders first and teachers so a broad range of ages | 22:10 |
| nixonix | imo eric feigl-ding dont usually mention much about those missing adjustments, when he shows these tables. and he is an epidemiologist | 22:12 |
| nixonix | ljl how did you find the oklahoma epidemiology surveillance reports? (something like googling the words on the left..?) i only found single pdf links, bad googling i guess | 22:19 |
| nixonix | oh yeah, just googling those 4 words worked | 22:20 |
| Brainstorm | New from r/WorldNews: worldnews: COVID-19: 'Get the jab or Get Another Job' Sajid Javid warns care workers → https://is.gd/LuXIIa | 22:21 |
| lastshell | nixonix age distribution of vaccines however doesnt split between vaccines https://www.mayoclinic.org/coronavirus-covid-19/vaccine-tracker | 22:30 |
| nixonix | jesus those vax rates are bad, esp at alabama and like | 22:38 |
| Brainstorm | Updates for Kuwait: +41 cases (now 411731), +1 deaths (now 2451), +21258 tests (now 4.3 million) since a day ago | 22:39 |
| nixonix | bulgaria and romania have the lowest vax coverage in eu. romania rocketing in cases, bulgaria having massive fatality numbers | 22:44 |
| LjL-Matrix | nixonix: I googled your own URL (within quotes) | 22:48 |
| nixonix | czechia is among the worst hit countries in europe, cases going up again. lets see what will happen this fall | 22:48 |
| nixonix | im surprised if it will be low cases gurgling and R remaining at 1 for long anywhere, if restrictions are removed | 22:50 |
| nixonix | denmark going up again. portugal not yet | 22:52 |
| nixonix | .title https://www.dailymail.co.uk/news/article-10048213/Gladys-Berejiklian-knifed-unelected-ICAC-lawyers-worst-time-Covid.html | 22:53 |
| Brainstorm | nixonix: From www.dailymail.co.uk: Gladys Berejiklian has been knifed by unelected ICAC lawyers at worst time with Covid | Daily Mail Online | 22:53 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): The US, now #50, is falling faster on the global vaccination list than on any reduction in cases or hospitalizations. ig.ft.com/coronavirus-va… pic.twitter.com/me6MCXvYww → https://is.gd/nzMble | 22:54 |
| nixonix | "would you publicly debate @GVDBossche about vaccine rates" | 22:57 |
| Brainstorm | Updates for Malawi: +12 cases (now 61609), +1 deaths (now 2283), +1195 tests (now 410582) since 23 hours ago | 23:04 |
| nixonix | PHE was criticized that they dint use correct age group data, and some people used ONS's data and possibly their own timings for vax doses etc, and got less waning effect. but its not confirmed that was correct either (although i think PHE wasnt) | 23:05 |
| nixonix | .title https://www.gov.uk/government/publications/covid-19-vaccine-surveillance-report page 17 | 23:05 |
| Brainstorm | nixonix: From www.gov.uk: COVID-19 vaccine surveillance reports (weeks 19 to 38) - GOV.UK | 23:05 |
| nixonix | .title https://twitter.com/PaulMainwood/status/1443951934457663488 with mainwood's adjustments | 23:09 |
| Brainstorm | nixonix: From twitter.com: Paul Mainwood (@PaulMainwood): "September (Week 38) Vaccine Surveillance. They still work. (Rates shown here use ONS population numbers, which almost certainly overstates UK 80+ population, so [...] | 23:09 |
| nixonix | while cant be sure thats correct either, id still look at age group 70-79, because younger had their vaxes later, with differing urgency to get the jab, and some of them got it early because hc worker etc status | 23:11 |
| nixonix | and some of 80+ got it with short dose interval | 23:11 |
| nixonix | VE vs hospitalization for 70-79 yo 82.7% ... idk, 6 months median since 2nd dose or something (i calculated this the last time, maybe ill check from logs...) | 23:13 |
| Brainstorm | New from COVID tweets: Eric Feigl-Ding (@DrEricDing): ⚠️KIDNEY FAILURE—Bad #LongCovid kidney damage in even non-hospitalized w/ no prior kidney problems ➡️2x higher risk of developing end-stage kidney disease, vs never had #COVID19. 📍That’s “+7.8 extra people needing dialysis or a kidney transplant per 10,000” with [... want %more?] → https://is.gd/UTzN9X | 23:15 |
| nixonix | .title https://twitter.com/dobssi/status/1443132428294438919/photo/2 | 23:23 |
| Brainstorm | nixonix: From twitter.com: Paul Collyer 🏴🇸🇪 (@dobssi): "As for serious cases. It is clear that the 3rd dose has a clear positive effect in 70+, but doesn't seem to make a huge difference below that. A good vaccine effect [...] | 23:23 |
| nixonix | it does for 60-69. younger got their doses later, but seems to be effective vs severe for under 60 still | 23:24 |
| nixonix | give it 1-2 months more, and the next age group suffers too, probably | 23:26 |
| nixonix | if that graph is recent, it seems 50-59 yo group had their vax around 6 months before infection leading to severe symptoms, so holding well vs severe for at least 6 months | 23:31 |
| nixonix | now back to that dutch immunologists opinion, epidemic getting mild because systemic response stays strong for long time, it doesnt seem to be true for over 60 yo, who are most at risk anyway | 23:33 |
| nixonix | but who knows, maybe it works for under 60 yo, so theres and age cutter in action. we live too long anyway after typical reproduction age nowdays... | 23:34 |
| nixonix | hey, it helps for pension costs if you delay the boosters | 23:36 |
| nixonix | yeah, i estimated the median time for 70-79 yo since the 2nd dose and before infection leading to severe was 4.75 months 2 weeks ago, so now it would be around 5 months (not 6), and those above using ONS's age group data instead of NIMS that PHE uses | 23:46 |
| nixonix | which ever is closer to truth (mainwood and james ward say ONS is closer). and combined VE (most pfizer, then az, and a little moderna i think) vs severe down to 82.7% with long intervals and 5 months (was 86% after 4.75 months), for 70-79 yo. thats all | 23:48 |
| Brainstorm | New from r/WorldNews: worldnews: India imposes retaliatory COVID restrictions on British nationals → https://is.gd/GbZzL7 | 23:56 |
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