| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): This is the critical data we never hear from ANYWHERE. When Israel, Singapore, UK or US have continued problems despite vaccines etc, to what extent is that bc some marginalized or unvaxed group is unwittingly seeding it? We need much more [... want %more?] → https://twitter.com/hjelle_brian/status/1451668078845050881 | 00:03 |
|---|---|---|
| Brainstorm | Updates for Bahrain: +66 cases (now 276461), +1 deaths (now 1393), +15860 tests (now 6.8 million) since 22 hours ago — Rwanda: +37 cases (now 99325), +2 deaths (now 1318), +15662 tests (now 3.0 million) since 23 hours ago | 00:06 |
| Brainstorm | Updates for Netherlands: +5902 cases (now 2.1 million) since 20 hours ago | 00:31 |
| Brainstorm | New from The Lancet (Online): [Review] The evolution of the Italian National Health Service: 40 years ago, Italy saw the birth of a national, universal health-care system (Servizio Sanitario Nazionale [SSN]), which provides a full range of health-care services with a free choice of [... want %more?] → https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01733-5/fulltext | 00:34 |
| Dredd | de-facto: I tried to give him a view from the other side and discuss critical thinking | 00:43 |
| Dredd | I also let his mum know I was concerned | 00:43 |
| Brainstorm | New from COVID tweets: Marc Veldhoen (@Marc_Veld): Fertility rates and birth outcomes after ChAdOx1 nCoV-19 (AZD1222) vaccination"We found no evidence of an association between reduced fertility and vaccination with ChAdOx1 nCoV-19."thelancet.com/journals/lance… → https://twitter.com/Marc_Veld/status/1451685429678428161 | 01:05 |
| sdfgsdfgs | lol finally... I WAS ITCHING FOR THIS NEWS | 01:06 |
| sdfgsdfgs | https://www.bbc.com/news/health-59009293 | 01:06 |
| sdfgsdfgs | .title | 01:07 |
| Brainstorm | sdfgsdfgs: From www.bbc.com: Delta 'Plus' Covid variant may be more transmissible - BBC News | 01:07 |
| sdfgsdfgs | they moved it to variant under investigation | 01:07 |
| sdfgsdfgs | it might get even more exciting by christmas :Ddd | 01:07 |
| Brainstorm | Updates for Argentina: +1385 cases (now 5.3 million), +23 deaths (now 115819), +51987 tests (now 24.7 million) since a day ago | 01:08 |
| sdfgsdfgs | or is this just a copy of the same news from a few days ago....hmm | 01:08 |
| de-facto | interesting, i wonder if there is a difference in for the quotient of attack rates for AY.4.2 per B.1.617.2 when comparing vaccinated with non-vaccinated | 01:10 |
| de-facto | ""This sub-lineage has become increasingly common in the UK in recent months, and there is some early evidence that it may have an increased growth rate in the UK compared to Delta," the UKHSA said." | 01:11 |
| sdfgsdfgs | that could only mean it spreads faster on vaccinated people | 01:11 |
| sdfgsdfgs | or stronger | 01:11 |
| LjL | i wonder why it's not even on outbreak.info | 01:12 |
| de-facto | ok so it got increased growth rate compared to its parent category delta, but how does that increased growth rate depend on immunity status | 01:12 |
| de-facto | e.g. to what degree is AY.4.2 selected for evading immunity compared with Delta | 01:12 |
| de-facto | immunity induced by vaccination with Wuhan-Hu-1 s-protein signature | 01:13 |
| de-facto | also does it have additional mutations outside of the s-protein that give it an reproduction advantage compared to Delta? | 01:14 |
| sdfgsdfgs | how long is this "investigation" going to take | 01:14 |
| de-facto | i only see them speaking about Y145H and A222V on s-protein, but what about all those NSPs? | 01:14 |
| sdfgsdfgs | uk scientists are lazy | 01:14 |
| de-facto | i still think those play a big role in evading innate immunity | 01:14 |
| LjL | UK scientists are wasting too much time waiting in the line for groceries | 01:15 |
| LjL | not enough time to science | 01:15 |
| de-facto | but it already spread to continental EU too, so we probably will just see a preview in UK as usual | 01:18 |
| de-facto | humans are very efficient in fast spreading the newest nasty mutants | 01:18 |
| de-facto | also in US | 01:28 |
| de-facto | so we can assume global spread i guess | 01:28 |
| de-facto | https://cov-lineages.org/lineage.html?lineage=AY.4.2 | 01:31 |
| LjL | oh, cov-lineages, just the one i hadn't tried | 01:33 |
| Brainstorm | Updates for Costa Rica: +1366 cases (now 555970), +51 deaths (now 6946), +53177 tests (now 2.5 million) since a day ago — Peru: +884 cases (now 2.2 million), +33 deaths (now 199978), +42266 tests (now 18.7 million) since a day ago | 01:33 |
| LjL | (or remembered about, tbh) | 01:33 |
| LjL | so this variant has been around for a while after all | 01:33 |
| LjL | first detected in *april 2020* O.o | 01:34 |
| LjL | that can't be right | 01:34 |
| Brainstorm | New from Politico: Black flags and crucifixes: Italy vaccine passport protests unite strange bedfellows: Anarchists, neo-fascists and radical left activists from Italy's social occupations are among those opposing the so-called green pass. → https://www.politico.eu/article/italy-vaccine-passport-protest-neo-fascists-green-pass/ | 01:37 |
| de-facto | btw politico is now Axel Springer, a horrible media group also owning BILD etc | 01:37 |
| Dredd | BILD? | 01:40 |
| Dredd | <LjL> "that can't be right" <- Doesn't sound right at all, AY.2 was only April 2021 afaik | 01:40 |
| Dredd | And AY.4.2 since ~July 2021? | 01:41 |
| Dredd | Lol, the old UK saying "may be more transmissible" | 01:42 |
| Dredd | Snap | 01:42 |
| Dredd | Same thing we said first about the kent variant | 01:42 |
| Dredd | then about delta | 01:42 |
| Dredd | "We as yet have no evidence blah blah" | 01:42 |
| LjL | Dredd, but if you look at the cov-lineages graph there's a very brief appearance in april 2020 | 01:42 |
| Dredd | I mean it clearly has some sort of selective advantage over plain delta now so there must be something (even if it's just superior herd immunity to plain delta) | 01:43 |
| LjL | it's not clear to me until i see it on outbreak.info :P | 01:43 |
| Dredd | This is so frustrating | 01:44 |
| Dredd | the same shit that happened here last year | 01:44 |
| LjL | and next year | 01:44 |
| Dredd | almost identical but new players | 01:44 |
| Dredd | We'll once again delay doing things till too late | 01:44 |
| LjL | yes | 01:44 |
| Dredd | christmas will happen whatever goes on | 01:44 |
| LjL | because that's what everyone has been doing from the start | 01:44 |
| Dredd | then the beginning of next year will be fucked | 01:44 |
| Dredd | and we'll be scrambling for new vaccines | 01:44 |
| LjL | would be foolish at this point to expect anything different | 01:44 |
| Dredd | I don't expect it but I do hope for it - I hope that we might have the capacity to use our great ability to communicate and surveil to realise on a population level to act according to logic and not due to our default behavioural drives | 01:45 |
| Dredd | And I still get frustrated even though I think it's quite likely to happen | 01:46 |
| de-facto | not too much on nextstrain ... yet? | 01:46 |
| de-facto | .title https://nextstrain.org/ncov/open/global?c=gt-S_145,222>=S.145H,222V | 01:46 |
| Brainstorm | de-facto: From nextstrain.org: auspice | 01:46 |
| LjL | <de-facto> btw politico is now Axel Springer, a horrible media group also owning BILD etc ← i don't know who it was owned by before, but i thought it was half decent, so i guess that's bad news | 01:46 |
| de-facto | LjL, we will see but i hate BILD with a passion, they are close to covidiot propaganda imho | 01:47 |
| LjL | Dredd, hope is happily not a bottleneck in the supply chain, you can have as much as you wish | 01:47 |
| Dredd | Give Boris time - I'm sure we can run out of hope due to lack of export from the EU | 01:48 |
| de-facto | it looks like there is not too much in the global databases (yet?) about AY.4.2 | 01:48 |
| Dredd | Like... now we aren't in it I wonder if there's anyway for the EU to screw Boris over manufacture of new vaccines | 01:48 |
| de-facto | maybe they need to get more upstream data? | 01:49 |
| Dredd | I wouldn't blame the EU politicians for trying it if possible | 01:49 |
| Dredd | de-facto: I think it doesn't help that they are calling it delta-plus when there is already material on that referring to another strain | 01:49 |
| de-facto | yeah its a completely stupid name | 01:50 |
| Dredd | blame the UK | 01:50 |
| Dredd | No one here has any awareness of India already having issues with a "delta-plus" | 01:50 |
| Dredd | So to us it just seemed like the natural thing to call it 🤦♂️ | 01:50 |
| LjL | Delta Plus Extra Power | 01:50 |
| LjL | Now Without Palm Oil | 01:51 |
| de-facto | lets just not use that name | 01:51 |
| LjL | besides, i bet Delta Airlines are as happy as Corona beer was | 01:51 |
| Dredd | Maybe we can call it the Fonzie vaccine??? 😆 AYYYYYYYYY.4.2 | 01:52 |
| LjL | if only it was a vaccine though | 01:52 |
| Dredd | Meant to say variant 😛 | 01:53 |
| LjL | still | 01:55 |
| de-facto | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1028113/Technical_Briefing_26.pdf | 01:57 |
| Brainstorm | New from r/WorldNews: worldnews: Canada scraps COVID-19 travel advisory; Ontario to end mask, vaccine rules by March → https://old.reddit.com/r/worldnews/comments/qdt889/canada_scraps_covid19_travel_advisory_ontario_to/ | 01:58 |
| de-facto | .title | 01:58 |
| Brainstorm | de-facto: From old.reddit.com: Canada scraps COVID-19 travel advisory; Ontario to end mask, vaccine rules by March : worldnews | 01:58 |
| de-facto | .title https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1028113/Technical_Briefing_26.pdf | 01:58 |
| Brainstorm | de-facto: From assets.publishing.service.gov.uk: SARS-CoV-2 variants of concern and variants under investigation (Public Health England) | 01:58 |
| LjL | hmm | 01:59 |
| LjL | isn't VUI technically a step below VOC? | 01:59 |
| LjL | so the one that is probably worse but *at least* as bad as the VOC is a VUI | 01:59 |
| sdfgsdfgs | ayyy420lmao | 02:00 |
| de-facto | "This lineage has the mutations of Delta and AY.4, and in addition S: A222V and Y145H. These mutations are in the N terminal domain. They could plausibly be biologically significant but there is minimal laboratory evidence." | 02:00 |
| de-facto | "The secondary attack rate for household contacts of cases with VUI-21OCT-01 was 12.4% (95% CI: 11.9% to 13.0%), higher than that observed for other Delta cases where it was 11.1% (95% CI: 11.0% to 11.2%). " | 02:00 |
| de-facto | "Based on these considerations and the high level of uncertainty, AY.4.2 was designated a new Variant Under Investigation, VUI-21OCT-01. " | 02:01 |
| sdfgsdfgs | whats the N terminal domain | 02:01 |
| sdfgsdfgs | it's the tail of the thing isnt it ? | 02:01 |
| sdfgsdfgs | the fluffy, hook tail | 02:01 |
| sdfgsdfgs | it's bigger now, and it's black | 02:02 |
| LjL | so page 19 of that document has the thing i would want from outbreak.info | 02:03 |
| sdfgsdfgs | link ? | 02:04 |
| LjL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1028113/Technical_Briefing_26.pdf | 02:04 |
| de-facto | "AY.4.2 includes the spike mutations A222V and Y145H, as well as the mutations seen in Delta and the AY.4 lineage. Y145H is in an area of the genome which has lower sequencing coverage with some primer sets. A222V is present in other clades outside AY.4.2." | 02:04 |
| de-facto | "Based on this analysis, the optimal surveillance case definition is a genome meeting the existing Delta genome case definition plus any 2 of the 3 mutations (orf1ab: A2529V; S: Y145H; S: A222V) where none of the positions are wild-type. This definition is highly specific (>99.9%) and sensitive (91.6%) for the clade in question." | 02:05 |
| sdfgsdfgs | whoa | 02:06 |
| sdfgsdfgs | look at the biodiversity of this thing | 02:06 |
| sdfgsdfgs | we are literally fueling evolution | 02:06 |
| LjL | we've looked for a while | 02:06 |
| LjL | we are the computation platforms for evolution | 02:06 |
| sdfgsdfgs | p19 chart is awesome | 02:07 |
| de-facto | the more diverse the broader the immunity needed to protect against all those variants | 02:07 |
| LjL | you can see similar charts on outbreak.info, only for earlier variants and other countries | 02:07 |
| de-facto | thats what i meant with spread of phylogenetic tree | 02:07 |
| sdfgsdfgs | where other AYs failed, 4.2 is digging itself a bigger slice | 02:07 |
| LjL | https://covid19.sanger.ac.uk/lineages/raw is otoh quite specific to English | 02:07 |
| LjL | but they don't seem up to date with the pluses | 02:08 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): If you want one of the letters I usually compile of the latest research and my opinion of safety of indoor schooling and masks and vaccines, you can go to this website:teamkinderschutz.deSome smart folk in Germany whipped it up for you [... want %more?] → https://twitter.com/fitterhappierAJ/status/1451699291056128002 | 02:08 |
| de-facto | "As of 21 October 2021, there are 22,017 VOC-21OCT-01 genomes in the UK dataset, linked to 15,120 cases in England. VUI-21OCT-01 accounts for 3.8%, 5.2%, and 5.9% of Delta cases in England in the weeks beginning 19 September, 26 September, and 3 October 2021 respectively (Figure 4)." | 02:09 |
| sdfgsdfgs | I'd like to look at this chart again in 2 weeks and decide to panic after that | 02:09 |
| de-facto | "These initial crude analyses do not show strong evidence of a difference in risk of hospitalisation or death between VUI-21OCT-01 and Delta. However, these analyses do not adjust for crucial factors that can influence outcomes such as age and vaccination status and should be interpreted with caution. " | 02:11 |
| Brainstorm | Updates for Bulgaria: +4826 cases (now 564719), +136 deaths (now 22975), +30764 tests (now 5.2 million) since a day ago — Bangladesh: +232 cases (now 1.6 million), +4 deaths (now 27805), +17100 tests (now 10.2 million) since a day ago | 02:11 |
| de-facto | but then on pages 14: cases wtih A&E visit Delta 0.25%, AY.4.2 0.31% and page 15: Deaths Delta 0.54% and AY.4.2 0.72% | 02:12 |
| de-facto | so 1.24-fold (+24%) more hospitalization and 1.33-fold (+33%) more fatal outcomes | 02:13 |
| Dredd | This is a fantastic document, thanks for sharing de-facto | 02:15 |
| de-facto | from yesterday :) | 02:15 |
| de-facto | "Based on a logistic growth model, the country-wide analysis yields a growth rate of 17% for AY.4.2 compared to other circulating variants" | 02:21 |
| de-facto | hence that explains all the graphs where it seems to be on the rise | 02:22 |
| LjL | https://lab24.ilsole24ore.com/coronavirus/ has a new (to me) graph with the incidence in vaccinated vs unvaccinated people ("Vaccinati/non vaccinati", i don't see a chapter link) | 02:22 |
| de-facto | "Secondary attack rate for household contacts of cases with VUI-21OCT-01 was 12.4% (95% CI: 11.9% to 13.0%), higher than that observed for other Delta cases where it was 11.1% (95% CI: 11.0% to 11.2%). In nonhousehold settings, the secondary attack rate was higher for VUI-21OCT-01 than other Delta cases, but this difference was not significant. No significant variation between regions was observed" | 02:24 |
| LjL | %tell Arsanerit: I had a look at the positive ratio in Italy and it's mixed news: overall, it's going down a lot, due to the many new tests that people took to get green passes; but if you look at "molecolari" (PCR) vs "antigenici" (rapid) here https://lab24.ilsole24ore.com/coronavirus/#box_6a unfortunately the PCR is going up, and that's more meaningful to me | 02:24 |
| Brainstorm | LjL, I'll pass Arsanerit your message when they are around. | 02:24 |
| * Dredd uploaded an image: (100KiB) < https://libera.ems.host/_matrix/media/r0/download/shortestpath.dev/HVCesSKGYCPMBnsyexkxLFqc/image.png > | 02:25 | |
| Dredd | So many cases in the young | 02:25 |
| LjL | :( | 02:25 |
| LjL | if so, then "it has similar death rates as other variants, but caveat: we didn't check for ages" isn't good news | 02:25 |
| de-facto | the least vaccinated group are the young | 02:26 |
| de-facto | .title https://coronavirus.data.gov.uk/ | 02:31 |
| Brainstorm | de-facto: From coronavirus.data.gov.uk: Daily summary | Coronavirus in the UK | 02:31 |
| de-facto | all the graphs are going up again in UK | 02:31 |
| Dredd | Yup, and a steep gradient | 02:31 |
| LjL | https://xkcd.com/2532/ | 02:31 |
| Dredd | lol | 02:32 |
| Brainstorm | Updates for Uruguay: +190 cases (now 391890), +1 deaths (now 6070), +9302 tests (now 3.8 million) since a day ago — Zimbabwe: +48 cases (now 132588), +1 deaths (now 4663), +3872 tests (now 1.5 million) since a day ago — Paraguay: +33 cases (now 460679), +1884 tests (now 1.9 million) since a day ago — United Kingdom: +48957 cases (now 8.7 million) since 23 hours ago | 02:36 |
| de-facto | .title https://covid19.sanger.ac.uk/lineages/raw?lineages=B.1.617.2%2CAY.4&colours=6%2C1&colorBy=p&lineage=AY.4 | 02:38 |
| Brainstorm | de-facto: From covid19.sanger.ac.uk: COVID-19 Genomic Surveillance â Wellcome Sanger Institute | 02:38 |
| de-facto | oh moment | 02:40 |
| de-facto | .title https://covid19.sanger.ac.uk/lineages/raw?lineages=B.1.617.2%2CAY.4.2&colours=6%2C0&colorBy=p&lineage=AY.4.2&scale=quadratic | 02:40 |
| Brainstorm | de-facto: From covid19.sanger.ac.uk: COVID-19 Genomic Surveillance â Wellcome Sanger Institute | 02:40 |
| LjL | de-facto, doesn't seem to work for me | 02:41 |
| LjL | "We‘re sorry, something went wrong." | 02:41 |
| LjL | with both of them it seems | 02:42 |
| de-facto | .title https://covid19.sanger.ac.uk/lineages/raw?lineages=B.1.617.2%2CAY.4.2&colours=6%2C0&colorBy=lambda&lineage=AY.4.2&scale=linear | 02:42 |
| Brainstorm | de-facto: From covid19.sanger.ac.uk: COVID-19 Genomic Surveillance â Wellcome Sanger Institute | 02:42 |
| de-facto | LjL, not sure for me those links seem to work | 02:43 |
| LjL | they don't for me... but anyway i don't understand, if i just go to https://covid19.sanger.ac.uk/lineages/raw why are the important sublineages like AY.4 and AY.4.2 not shown? | 02:46 |
| de-facto | so mostly spreading in UK from Cheshire East, Stockport, Birmingham, Solihull, Aylesbury vale, Milton Keynes, Wiltshire and Dorset | 02:46 |
| LjL | oh i have to click on the gear | 02:46 |
| de-facto | Ljl click on the upper roght corner on the Lineages | 02:47 |
| de-facto | yeah | 02:47 |
| Brainstorm | Updates for Gabon: +320 cases (now 34601), +5 deaths (now 224), +7641 tests (now 1.3 million) since a day ago — Guinea: +21 cases (now 30626), +596 tests (now 564887) since a day ago — Curacao: +14 cases (now 16998), +1646 tests (now 300586) since a day ago | 03:01 |
| de-facto | https://nextstrain.org/ncov/open/global?c=gt-S_145,222>=S.145H,222V,ORF1a.2529V | 03:01 |
| de-facto | hmm somehow only very few UK sequences are there | 03:02 |
| de-facto | https://nextstrain.org/ncov/gisaid/global?c=gt-S_145,222>=S.145H,222V,ORF1a.2529V | 03:03 |
| de-facto | maybe the majority of UK sequences does not land in those databases for some reason | 03:04 |
| LjL | https://twitter.com/BallouxFrancois/status/1449217846593064963#m | 03:14 |
| de-facto | thats a good explanation twitter thread | 03:23 |
| Brainstorm | New from r/WorldNews: worldnews: NIH says grantee failed to report experiment in Wuhan that created a bat virus that made mice sicker | Science → https://old.reddit.com/r/worldnews/comments/qdup8p/nih_says_grantee_failed_to_report_experiment_in/ | 03:32 |
| de-facto | https://outbreak.info/situation-reports?pango=AY.4&muts=S%3AY145H&muts=S%3AA222V&muts=ORF1a%3AA2529V&loc=USA&loc=GBR&loc=DNK&loc=DEU&selected=GBR&overlay=false | 03:32 |
| de-facto | .title | 03:32 |
| Brainstorm | de-facto: From outbreak.info: outbreak.info | 03:32 |
| Brainstorm | de-facto: From outbreak.info: outbreak.info | 03:32 |
| de-facto | LjL, there is AY.4.2 in outbreak.info (had to add the defining mutations manually) | 03:33 |
| de-facto | at least 14,124 sequences in 27 countries, mostly UK, Denmark, Germany, US, ... | 03:35 |
| Brainstorm | Updates for Barbados: +427 cases (now 14753), +2 deaths (now 126), +2555 tests (now 369920) since a day ago — Panama: +193 cases (now 471253), +3 deaths (now 7306), +7637 tests (now 4.0 million) since 23 hours ago — Channel Islands: +63 cases (now 12594), +20398 tests (now 994148) since 20 hours ago [... want %more?] | 03:38 |
| de-facto | .title https://www.biorxiv.org/content/10.1101/2021.05.06.442903v2 | 03:42 |
| Brainstorm | de-facto: From www.biorxiv.org: A phylogeny-based metric for estimating changes in transmissibility from recurrent mutations in SARS-CoV-2 | bioRxiv | 03:42 |
| Brainstorm | New from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): Real-life implication: If you're J&J, you're best off with Moderna50 booster (by intrapolation) then Pfizer booster for both antibodies and T cell function.This confirms our earlier conclusion from the the NIH and Singapore studiestwitter.com/michaelzlin/st… → https://twitter.com/michaelzlin/status/1451724605182255105 | 03:42 |
| de-facto | https://twitter.com/michaelzlin/status/1450988678386372609 | 03:44 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.10.10.21264827v2 | 03:48 |
| Brainstorm | de-facto: From www.medrxiv.org: Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report | medRxiv | 03:48 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.10.14.21264981v1.full | 03:50 |
| Brainstorm | de-facto: From www.medrxiv.org: Differential immunogenicity of homologous versus heterologous boost in Ad26.COV2.S vaccine recipients | medRxiv | 03:50 |
| Brainstorm | Updates for Peru: +1043 cases (now 2.2 million), +25 deaths (now 200003), +45710 tests (now 18.7 million) since 2 hours ago | 04:03 |
| Brainstorm | New from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): P.S. noting again that lower effectiveness of J&J booster vs Pfizer booster here may be partly due to anti-adenovirus antibodies from the initial J&J vaccination clearing some particles from the J&J booster before they can infect cells → https://twitter.com/michaelzlin/status/1451737540617138184 | 04:34 |
| Brainstorm | Updates for South Korea: +1507 cases (now 350476), +20 deaths (now 2745), +44086 tests (now 15.5 million) since a day ago — New Zealand: +104 cases (now 5554), +24086 tests (now 3.9 million) since 23 hours ago — United Kingdom: +48920 cases (now 8.7 million) since 23 hours ago — Netherlands: +5893 cases (now 2.1 million) since 23 hours ago | 04:40 |
| Brainstorm | New from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): Pfizer's application for the vaccine for 5-11yo is progressing well.FDA analysis is positive on efficacy and safety, no red flagsVRBPAC meeting Tuesday to discuss. I think we may get FDA approval by end of month.cnbc.com/2021/10/23/fda… → https://twitter.com/michaelzlin/status/1451748143305871367 | 05:16 |
| de-facto | .title https://www.medrxiv.org/content/10.1101/2021.10.14.21264965v1 | 05:24 |
| Brainstorm | de-facto: From www.medrxiv.org: REACT-1 study round 14: High and increasing prevalence of SARS-CoV-2 infection among school-aged children during September 2021 and vaccine effectiveness against infection in England | medRxiv | 05:24 |
| Brainstorm | Updates for Belgium: +6682 cases (now 1.3 million), +11 deaths (now 25846) since 23 hours ago — Bolivia: +574 cases (now 509276), +5 deaths (now 18896), +6899 tests (now 2.5 million) since a day ago | 05:30 |
| Brainstorm | New from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): I'm most impressed that Pfizer seemed to have picked the Goldilocks dosage. 10ug was enough to get 90% VE against Delta, yet is only 1/3 of the dosage for ≥12yo → https://twitter.com/michaelzlin/status/1451756442034196490 | 05:47 |
| Brainstorm | New from COVID tweets: Michael Lin, PhD-MD 🧬 (@michaelzlin): For the curious, the trips to the ICU for myocarditis probably involve intravenous immunoglobulin and steroids as rapid-acting anti-inflammatoriespediatrics.aappublications.org/content/pediat… → https://twitter.com/michaelzlin/status/1451761747119915014 | 06:08 |
| Brainstorm | New from r/WorldNews: worldnews: Australia's Melbourne enjoys weekend of eased COVID curbs after long lockdown → https://old.reddit.com/r/worldnews/comments/qdxllq/australias_melbourne_enjoys_weekend_of_eased/ | 06:29 |
| Brainstorm | Updates for Germany: +15093 cases (now 4.5 million) since 23 hours ago — India: +16326 cases (now 34.2 million) since 23 hours ago | 06:32 |
| Brainstorm | New from r/WorldNews: worldnews: Delta 'Plus' Covid variant may be more transmissible → https://old.reddit.com/r/worldnews/comments/qdxp1m/delta_plus_covid_variant_may_be_more_transmissible/ | 06:39 |
| Brainstorm | New from r/Science: science: Conservatives have accused social media platforms of being biased against them, whereas a study finds that the reason conservative content was disproportionately removed is because they posted more content that was offensive or allegedly so, [... want %more?] → https://old.reddit.com/r/science/comments/qdxu4x/conservatives_have_accused_social_media_platforms/ | 06:50 |
| Brainstorm | New from The Indian Express: World: US: Illegal border crossings, driven by pandemic and natural disasters, soar to record high → https://indianexpress.com/article/world/us-illegal-border-crossings-covid-19-pandemic-natural-disasters-7586040/ | 07:11 |
| Brainstorm | New from The Indian Express: World: Covid-19 vaccines not linked to pregnancy loss; mixing vaccines may confer greater protection, studies show → https://indianexpress.com/article/world/covid-19-vaccines-not-linked-to-pregnancy-loss-mixing-vaccines-may-confer-greater-protection-studies-show-7586113/ | 07:31 |
| Brainstorm | Updates for Gansu, China: +17 cases (now 235) since a day ago — Lombardy, Italy: +381 cases (now 890542), +4 deaths (now 34135) since a day ago — Beijing, China: +6 cases (now 1136) since a day ago | 07:34 |
| Brainstorm | New from r/WorldNews: worldnews: China reports 50 new Covid-19 cases, 6 in Beijing → https://old.reddit.com/r/worldnews/comments/qdypr0/china_reports_50_new_covid19_cases_6_in_beijing/ | 07:52 |
| Brainstorm | New from The Indian Express: World: Australia’s Melbourne enjoys weekend of eased COVID curbs after long lockdown → https://indianexpress.com/article/world/australia-melbourne-reopen-covid-lockdown-eased-7586161/ | 08:02 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | October 23, 2021: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/qdztx0/daily_discussion_thread_october_23_2021/ | 09:04 |
| Brainstorm | Updates for Georgia: +4467 cases (now 688804), +42 deaths (now 9699), +52487 tests (now 9.9 million) since a day ago — Czechia: +4244 cases (now 1.7 million), +15 deaths (now 30608), +143659 tests (now 39.8 million) since a day ago — Armenia: +1962 cases (now 293014), +31 deaths (now 5975), +16888 tests (now 2.0 million) since 22 hours ago | 09:39 |
| Brainstorm | Updates for Lithuania: +3186 cases (now 385640), +31 deaths (now 5602), +25448 tests (now 5.4 million) since a day ago | 10:04 |
| Brainstorm | Updates for Estonia: +1642 cases (now 180252), +10 deaths (now 1454), +8990 tests (now 2.1 million) since 23 hours ago — Cayman Is.: +31 cases (now 1196), +574 tests (now 136780) since a day ago — Taiwan: +7 cases (now 16364), +93474 tests (now 7.2 million) since a day ago — Germany: +6926 cases (now 4.5 million) since 17 hours ago | 10:41 |
| Brainstorm | New from New Scientist: How much less likely are you to spread covid-19 if you're vaccinated?: Vaccination still greatly reduces the risk of infecting others despite the arrival of the delta variant, recent studies show → https://www.newscientist.com/article/2294250-how-much-less-likely-are-you-to-spread-covid-19-if-youre-vaccinated/ | 10:49 |
| sdfgsdfgs | delta is so old news now | 10:51 |
| Arsanerit | I'm surprised we're not yet overrun by omega | 10:56 |
| Brainstorm | Arsanerit: At 2021-10-23 00:24:29 UTC, LjL told you: I had a look at the positive ratio in Italy and it's mixed news: overall, it's going down a lot, due to the many new tests that people took to get green passes; but if you look at "molecolari" (PCR) vs "antigenici" (rapid) here https://lab24.ilsole24ore.com/coronavirus/#box_6a unfortunately the PCR is going up, and that's more meaningful to me | 10:56 |
| Brainstorm | New from The Indian Express: World: Canada scraps Covid travel advisory; Ontario to end mask, vaccine rules by March → https://indianexpress.com/article/world/canada-scraps-covid-travel-advisory-ontario-to-end-mask-vaccine-rules-by-march-7586038/ | 11:09 |
| Brainstorm | Updates for Austria: +3756 cases (now 794982), +12 deaths (now 11245), +315989 tests (now 94.6 million) since a day ago | 12:08 |
| Brainstorm | Updates for Indonesia: +802 cases (now 4.2 million), +23 deaths (now 143176), +250587 tests (now 44.8 million) since 23 hours ago — Laos: +467 cases (now 34985), +1 deaths (now 50), +5717 tests (now 592472) since 23 hours ago — United Kingdom: +49005 cases (now 8.7 million) since 20 hours ago | 12:33 |
| Brainstorm | Updates for Latvia: +2932 cases (now 200321), +26 deaths (now 3018), +20218 tests (now 4.8 million) since 22 hours ago | 13:10 |
| Brainstorm | New from COVID tweets: Prof Francois Balloux (@BallouxFrancois): October 2021, the UK rejoined the EU ... (in terms of daily COVID-19 deaths per million people). pic.twitter.com/TLm5HcRmy5 → https://twitter.com/BallouxFrancois/status/1451872150948884483 | 13:34 |
| Brainstorm | Updates for Romania: +15261 cases (now 1.6 million), +446 deaths (now 44290), +72178 tests (now 14.3 million) since 22 hours ago | 14:00 |
| Brainstorm | New from Gazzetta Ufficiale italiana: MINISTERO DELLA SALUTE - ORDINANZA 22 ottobre 2021: Ulteriori misure urgenti in materia di contenimento e gestionedell'emergenza epidemiologica da COVID-19. (21A06358) → http://www.gazzettaufficiale.it/eli/id/2021/10/23/21A06358/SG | 14:16 |
| Brainstorm | Updates for Nepal: +438 cases (now 808534), +8 deaths (now 11345), +4972 tests (now 4.4 million) since a day ago — Gibraltar: +16 cases (now 5858), +783 tests (now 380212) since a day ago | 14:37 |
| Brainstorm | New from COVID tweets: Jon Levy (@jonlevyBU): Kids are major drivers of #covid19 in MA right now. And kids live with adults, who are being placed at increased risk. We need to aggressively roll out vaccines for age 5-11 once approved, but also maintain masking and smart policies over these next crucial months. [... want %more?] → https://twitter.com/jonlevyBU/status/1451896909250105357 | 15:10 |
| Brainstorm | New from StatNews: FDA scientists say benefits of Pfizer Covid-19 vaccine ‘clearly outweigh’ the risks for children ages 5 to 11: One of the big questions to be examined at Tuesday's FDA advisory committee meeting is whether [... want %more?] → https://www.statnews.com/2021/10/23/fda-scientists-say-benefits-of-pfizer-covid-19-vaccine-clearly-outweigh-the-risks-for-children-ages-5-to-11/ | 15:20 |
| Brainstorm | Updates for Belarus: +2079 cases (now 584190), +17 deaths (now 4499), +40590 tests (now 9.3 million) since a day ago — Bangladesh: +278 cases (now 1.6 million), +9 deaths (now 27814), +15042 tests (now 10.2 million) since 13 hours ago — Brunei: +229 cases (now 11901), +1 deaths (now 80), +3529 tests (now 468587) since a day ago [... want %more?] | 15:39 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): COVID spokesvirus: Humans stupider than BATS. twitter.com/TheTorontoSun/… → https://twitter.com/hjelle_brian/status/1451907054709338116 | 15:52 |
| Brainstorm | Updates for UAE: +84 cases (now 739190), +1 deaths (now 2129), +299806 tests (now 91.0 million) since a day ago — Saudi Arabia: +43 cases (now 548205), +2 deaths (now 8776), +36859 tests (now 30.0 million) since a day ago | 16:04 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Just out @NEJM "Uncomfortable Truths — What Covid-19 Has Revealed about Chronic-Disease Care in America"and what to do about itnejm.org/doi/full/10.10… by @MarshallChinMD @UChicago pic.twitter.com/ZfdySojeWV → https://twitter.com/EricTopol/status/1451913278871932929 | 16:13 |
| de-facto | .title https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00219-6/fulltext | 16:21 |
| Brainstorm | de-facto: From www.thelancet.com: The durability of immunity against reinfection by SARS-CoV-2: a comparative evolutionary study - The Lancet Microbe | 16:21 |
| de-facto | "We conducted phylogenetic analyses of the S, M, and ORF1b genes to reconstruct a maximum-likelihood molecular phylogeny of human-infecting coronaviruses. This phylogeny enabled comparative analyses of peak-normalised nucleocapsid protein, spike protein, and whole-virus lysate IgG antibody optical density levels, in conjunction with reinfection data on endemic human-infecting coronaviruses." | 16:21 |
| de-facto | "We performed ancestral and descendent states analyses to estimate the expected declines in antibody levels over time, the probabilities of reinfection based on antibody level, and the anticipated times to reinfection after recovery under conditions of endemic transmission for SARS-CoV-2, as well as the other human-infecting coronaviruses." | 16:22 |
| de-facto | "We obtained antibody optical density data for six human-infecting coronaviruses, extending from 128 days to 28 years after infection between 1984 and 2020. These data provided a means to estimate profiles of the typical antibody decline and probabilities of reinfection over time under endemic conditions. " | 16:22 |
| de-facto | "Reinfection by SARS-CoV-2 under endemic conditions would likely occur between 3 months and 5·1 years after peak antibody response, with a median of 16 months." | 16:22 |
| de-facto | "This protection is less than half the duration revealed for the endemic coronaviruses circulating among humans (5–95% quantiles 15 months to 10 years for HCoV-OC43, 31 months to 12 years for HCoV-NL63, and 16 months to 12 years for HCoV-229E). " | 16:22 |
| de-facto | "For SARS-CoV, the 5–95% quantiles were 4 months to 6 years, whereas the 95% quantiles for MERS-CoV were inconsistent by dataset." | 16:23 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): What happens when teens are not vaccinatedft.com/content/1f5783… pic.twitter.com/0NyyJWX4Ob → https://twitter.com/EricTopol/status/1451916283138621449 | 16:23 |
| Brainstorm | Updates for Eq. Guinea: +69 cases (now 13166), +17058 tests (now 238486) since 2 days ago — Djibouti: +8 cases (now 13444), +1338 tests (now 233338) since 20 hours ago | 16:29 |
| Brainstorm | New from r/Science: science: Individuals who believe in COVID conspiracy theories are more likely to test positive for Covid and violate public health regulations, as well as experience job loss, reduced income, social rejection, and decreased overall well-being. → https://old.reddit.com/r/science/comments/qe5wte/individuals_who_believe_in_covid_conspiracy/ | 16:44 |
| Brainstorm | New from COVID tweets: Eric Topol (@EricTopol): Features of #LongCovid among >157,000 adults and children with Covid infections with matched controlsmedrxiv.org/cgi/content/sh… Lower absolute incidence in children and teens but impact statistically significant across all age groups pic.twitter.com/RaXg21Ba5Z → https://twitter.com/EricTopol/status/1451926435409530886 | 17:05 |
| Brainstorm | Updates for India: +17008 cases (now 34.2 million), +679 deaths (now 453780) since 23 hours ago | 17:06 |
| Brainstorm | New from The Indian Express: World: Austrian chancellor threatens lockdown for unvaccinated → https://indianexpress.com/article/world/austria-chancellor-threatens-lockdown-for-unvaccinated-7587153/ | 17:26 |
| Brainstorm | Updates for Netherlands: +5711 cases (now 2.1 million), +23 deaths (now 18750) since 23 hours ago — Chile: +1994 cases (now 1.7 million), +68245 tests (now 23.1 million) since a day ago — Canada: +2588 cases (now 1.7 million), +50 deaths (now 28787) since 21 hours ago | 17:31 |
| Brainstorm | New from Reddit (test): Saturday 23 October 2021 Update: submitted by /u/HippolasCage to r/CoronavirusUK → https://old.reddit.com/r/CoronavirusUK/comments/qe7dpp/saturday_23_october_2021_update/ | 18:07 |
| Brainstorm | Updates for United Kingdom: +4284 cases (now 8.7 million) since 22 hours ago — Italy: +3905 cases (now 4.7 million), +39 deaths (now 131802), +491574 tests (now 100.6 million) since a day ago — Dominican Rep.: +823 cases (now 375545), +6 deaths (now 4106), +5063 tests (now 2.2 million) since 22 hours ago [... want %more?] | 18:09 |
| Brainstorm | New from r/WorldNews: worldnews: Rich countries saved themselves during the pandemic. Poorer countries are reeling → https://old.reddit.com/r/worldnews/comments/qe7xa4/rich_countries_saved_themselves_during_the/ | 18:38 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): CDC says delta COVID not more severe than that from prior agents. Hard to believe given 1000x higher viral load but data be data.cdc.gov/mmwr/volumes/7… → https://twitter.com/hjelle_brian/status/1451953797689798661 | 18:59 |
| Brainstorm | Updates for India: +15864 cases (now 34.2 million), +559 deaths (now 454301) since 20 hours ago | 19:36 |
| Brainstorm | Updates for Kuwait: +25 cases (now 412506), +14036 tests (now 4.7 million) since 23 hours ago | 20:01 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): The gbd and aier have promoted variants and lockdowns by advocating for the evolution of cov2 by infection-based pursuit of herd immunity twitter.com/PhilWMagness/s… → https://twitter.com/fitterhappierAJ/status/1451970674323595264 | 20:01 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): The first thing to know is that no "developer" of the weirdly-inefficient COVID agent would be positioned to have the slightest clue as to how their Frankenstein would behave if it hit humans.That is huge. → https://twitter.com/hjelle_brian/status/1451975815344787457 | 20:21 |
| jbwncster | https://thehill.com/policy/international/europe/578137-austrian-chancellor-considering-implementing-lockdown-for | 20:24 |
| Brainstorm | New from COVID tweets: Anthony J Leonardi, PhD, MS (@fitterhappierAJ): Are these the NDPR board members?I think allowing kids to be infected is unethical. twitter.com/COVIDforKids/s… pic.twitter.com/7OdKYuneno → https://twitter.com/fitterhappierAJ/status/1451978927975636997 | 20:32 |
| Brainstorm | Updates for Canada: +2317 cases (now 1.7 million) since 23 hours ago | 20:38 |
| Brainstorm | Updates for Maldives: +225 cases (now 86830), +4527 tests (now 1.6 million) since a day ago | 21:03 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): The irony isn't just that any scenario of Wuhan accidentally releasing Bad Bat Virus on world was likely done 100% within published international norms of biosafety. The irony is that China knew world couldn't handle it, even if innocent. → https://twitter.com/hjelle_brian/status/1451988846858489857 | 21:13 |
| Brainstorm | New from r/WorldNews: worldnews: Sweden Suspends Moderna Vaccine Indefinitely for People Under 31, Fear 'Increased Risk' of Heart Problems → https://old.reddit.com/r/worldnews/comments/qebj90/sweden_suspends_moderna_vaccine_indefinitely_for/ | 21:44 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): COVID spokesvirus getting defensive. Guess who took out Roy Cohn, criminal mentor and defender of McCarthy, Nixon and trump?That's right. A virus. pic.twitter.com/fnNTUkWOX5 → https://twitter.com/hjelle_brian/status/1451997721225674754 | 21:54 |
| Brainstorm | New from r/Science: science: Sweden Suspends Moderna Vaccine Indefinitely for People Under 31, Fear 'Increased Risk' of Heart Problems → https://old.reddit.com/r/science/comments/qecb0j/sweden_suspends_moderna_vaccine_indefinitely_for/ | 22:26 |
| Brainstorm | New from COVID tweets: Brian Hjelle, virologist (@hjelle_brian): You may recall this account saying this many months back.Despite Fauci parsing, we funded GoF in Wuhan.To almost certainly no consequence, but embarrassing. vanityfair.com/news/2021/10/n… → https://twitter.com/hjelle_brian/status/1452007966253584385 | 22:36 |
| Brainstorm | New from r/Science: science: Vitamin K & D Deficiencies Are Independently Associated With COVID-19 Disease Severity. Early in acute COVID-19, both vitamin K & vitamin D deficiency were independently associated with worse COVID-19 disease severity, suggesting a potential synergistic [... want %more?] → https://old.reddit.com/r/science/comments/qed6vy/vitamin_k_d_deficiencies_are_independently/ | 23:07 |
| Brainstorm | Updates for India: +15281 cases (now 34.2 million) since 16 hours ago | 23:07 |
| Brainstorm | Updates for Germany: +2343 cases (now 4.5 million) since 16 hours ago | 23:32 |
| Brainstorm | New from COVID tweets: Derek Lowe (@Dereklowe): Why do I say this? Because Rep. Roy is a survivor of Hodgkin’s lymphoma. He was treated successfully with an antibody-drug conjugate. (3/5) twitter.com/repchiproy/sta… → https://twitter.com/Dereklowe/status/1452030362629124096 | 23:58 |
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