| Brainstorm | New from NPR Science: These Brazilian besties are inventing an mRNA vaccine as a gift to the world: Pfizer and Moderna have refused to divulge details of how to make their cutting-edge COVID shots. Here's what two scientists — and [... want %more?] → https://www.npr.org/sections/goatsandsoda/2022/07/13/1111137152/these-brazilian-besties-are-inventing-an-mrna-vaccine-as-a-gift-to-the-world | 00:02 |
|---|---|---|
| Brainstorm | Updates for Ukraine: +159698 cases, +3167 deaths since 22 hours ago — Turkey: +117095 cases, +31 deaths since 9 days ago — Albania: +1563 cases, +1 deaths since a day ago — Kazakhstan: +820 cases since a day ago | 00:05 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Ladder diagram of variant growth advantage, shown at yesterday's @WHCOVIDResponse BA.5 press briefing youtube.com/watch?v=fHyPEN… by Tony Fauci pic.twitter.com/e0TVBnbPJF → https://twitter.com/EricTopol/status/1547340410522968069 | 00:12 |
| Timvde | What a weird and imprecise graph | 00:17 |
| Timvde | Random question, but did we reach a conclusion about the effectiveness of the Sputnik vaccine? | 00:18 |
| LjL | not i | 00:44 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): @TWenseleers @jorgenponder @xabitron1 @Jean__Fisch Yes. Go to escape calculator (jbloomlab.github.io/SARS2_RBD_Ab_e…), select antibodies that neutralize BA.2, shift-click RBD sites mutated in BA.2.75 relative to BA.2. Results below. For current vax, next escape [... want %more?] → https://twitter.com/jbloom_lab/status/1547350891467902976 | 00:50 |
| Brainstorm | Updates for Brazil: +71501 cases, +316 deaths since 21 hours ago — Bahrain: +1694 cases, +6549 tests since a day ago | 01:02 |
| LjL | another Ukraine update, i can't even be bothered trying to figure out who puts out the data but perhaps someone should | 01:05 |
| Brainstorm | New from COVID on Twitter: Bloom Lab (@jbloom_lab): @TWenseleers @jorgenponder @xabitron1 @Jean__Fisch Caveat: these are just predictions of what sites cause most escape. Evolution depends on more than just antibody escape. And it's still speculative that BA.2.75 will spread. But regardless of what BA.2 or BA.5 [... want %more?] → https://twitter.com/jbloom_lab/status/1547355773155434499 | 01:09 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): @PeacockFlu @MarionKoopmans @WHO Well in Maharashtra most BA.2.75 cases were found in Aurangabad & Nagpur and in those two cities/districts cases are increasing... Since they comprise only about 4% of the population of Maharashtra, you can't yet see the [... want %more?] → https://twitter.com/TWenseleers/status/1547357073490452480 | 01:18 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): @jbloom_lab @jorgenponder @xabitron1 @Jean__Fisch Very cool - thanks! Are you in touch with any of the vaccine manufacturers or medicine agencies to try to push them to include these likely future mutations in updated vaccine boosters and approve them for use? → https://twitter.com/TWenseleers/status/1547363088449634304 | 01:38 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): It's already approved as a booster in many countries. Given that the delay in the US was supposedly because FDA has stricter manufacturing criteria, and given that FDA has approved vax with worse efficacy data (e.g. Pfizer for little kids) then US [... want %more?] → https://twitter.com/michaelzlin/status/1547368721471381504 | 01:57 |
| Brainstorm | New from ##covid-19 Zotero group: U.S. FDA Grants Emergency Use Authorization for Novavax COVID-19 Vaccine, Adjuvanted for Individuals Aged 18 and Over: Type Web Page URL [... want %more?] → https://www.zotero.org/groups/covid_links/items/WN3JM8IN | 02:06 |
| Brainstorm | Updates for Guatemala: +7747 cases, +8 deaths, +44448 tests since 20 hours ago — Canada: +4960 cases since 23 hours ago | 02:10 |
| Brainstorm | New from COVID on Twitter: Jeffrey Barrett (@jcbarret): @jbloom_lab I wonder if there’s a technical/immunological reason why you couldn’t make the vax payload a high complexity mix of spike RNAs? So far the best we’ve done is a 50:50 mix of Wuhan and a variant (I think). Would it lead to poor antibody response [... want %more?] → https://twitter.com/jcbarret/status/1547373741222629377 | 02:16 |
| Brainstorm | Updates for Mexico: +37346 cases, +72 deaths since 21 hours ago — Kenya: +239 cases, +4473 tests since a day ago — France: +249 cases since 4 hours ago | 03:00 |
| LjL | Vaccination against SARS-CoV-2 lowers the risk of long COVID after infection by only about 15%, according to a study of more than 13 million people | 03:10 |
| LjL | https://www.nature.com/articles/d41586-022-01453-0 | 03:10 |
| LjL | https://www.nature.com/articles/s41591-022-01840-0 | 03:12 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Latest review of incidence and natural history of myocarditis/pericarditis following Covid vaccination with 46 studies, >8,000 total cases @bmj_latest bmj.com/content/378/bm… pic.twitter.com/wgLovIvr2l → https://twitter.com/EricTopol/status/1547386739076919296 | 03:13 |
| Brainstorm | New from ##covid-19 Zotero group: Long COVID risk falls only slightly after vaccination, huge study shows: Type Journal Article Author Sara Reardon URL https://www.nature.com/articles/d41586-022-01453-0 Rights 2022 Springer Nature Limited Publication Nature Date 2022-05-25 DOI 10.1038/d41586-022-01453-0 Accessed [... want %more?] → https://www.zotero.org/groups/covid_links/items/TR9WRIHI | 03:22 |
| Brainstorm | New from COVID on Twitter: Naomi Wu 机械妖姬 (@RealSexyCyborg): Pro-tip for the COVID education crowd. You're where you're at in large part because you and yours either indulged in or turned a blind eye to anti-Asian racism. You didn't accept our warnings, our protocols, our studies- you called our measures theater. → https://twitter.com/RealSexyCyborg/status/1547389725895704576 | 03:51 |
| Brainstorm | Updates for Eritrea: +17 cases since 2 days ago | 04:03 |
| Brainstorm | New from COVID on Twitter: Scott Gottlieb, MD (@ScottGottliebMD): The more than 1,000 monkeypox cases documented in the U.S. so far are probably just a fraction of the actual cases as the undeclared pandemic expands. apnews.com/article/health… → https://twitter.com/ScottGottliebMD/status/1547404870596153345 | 04:20 |
| Brainstorm | New from r/COVID19: COVID19: Epigallocatechin gallate (EGCG) attenuates severe acute respiratory coronavirus disease 2 (SARS-CoV-2) infection by blocking the interaction of SARS-CoV-2 spike protein receptor-binding domain to human angiotensin-converting enzyme 2 → https://old.reddit.com/r/COVID19/comments/vykyxc/epigallocatechin_gallate_egcg_attenuates_severe/ | 04:39 |
| Brainstorm | Updates for South Korea: +39169 cases, +16 deaths since 23 hours ago — Australia: +47467 cases, +90 deaths since 23 hours ago | 04:59 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Indeed Novavax has already asked for approval as a booster. From CNN: "We've talked with the FDA quite a bit about this... I believe the FDA will be addressing that approval within weeks."cnn.com/2022/07/13/hea… pic.twitter.com/ytirSWqRtg → https://twitter.com/michaelzlin/status/1547418867542044679 | 05:17 |
| Brainstorm | Updates for Germany: +152149 cases, +145 deaths since 23 hours ago | 06:01 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: One in 25 people develop long Covid after catching the virus → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vyn8zj/one_in_25_people_develop_long_covid_after/ | 06:41 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: New research provides insight into Long COVID and ME, News, University of Otago, New Zealand → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vynb7v/new_research_provides_insight_into_long_covid_and/ | 06:50 |
| Brainstorm | Updates for Peru: +12538 cases, +17 deaths since 23 hours ago — Bolivia: +4173 cases, +4 deaths since a day ago | 07:10 |
| Brainstorm | Updates for England, United Kingdom: +171786 cases, +850 deaths since 7 days ago — Washington, United States: +76206 cases, +837 deaths since a day ago — Lower Saxony, Germany: +29646 cases, +23 deaths since 23 hours ago — Georgia, United States: +26603 cases, +136 deaths since 7 days ago | 08:07 |
| Timvde | de-facto: first RAT post-isolation, in the morning before drinking or anything as you said, is negative :) | 08:15 |
| Timvde | I will still WFM and have only outside activities planned the next couple of days, just to be sure, but at least I have things planned again :D | 08:16 |
| Brainstorm | New from WebMD: Lead Exposure Is Still a Problem for Kids, and the Pandemic Has Made It Worse: Even low levels of lead exposure can lower cognitive performance, cause learning difficulties, and prompt behavior issues. And we’ve stopped testing for it. → https://www.webmd.com/children/features/lead-exposure-children | 08:24 |
| Brainstorm | New from r/Coronavirus: Daily Discussion Thread | July 14, 2022: Please refer to our Wiki for more information on COVID-19 and our sub. You can find answers to frequently asked questions in our FAQ , where there is valuable information such as our: → https://old.reddit.com/r/Coronavirus/comments/vypjw2/daily_discussion_thread_july_14_2022/ | 09:02 |
| Brainstorm | Updates for Kazakhstan: +1124 cases since 8 hours ago | 09:03 |
| Brainstorm | New from COVID on Twitter: The Economist (@TheEconomist): Without vaccines, the Delta- and Omicron-variant waves would have been almost three times deadlier, research suggests econ.st/3axz5tN → https://twitter.com/TheEconomist/status/1547480085711691778 | 09:21 |
| Brainstorm | Updates for Laos: +32 cases since a day ago — Cambodia: +17 cases since a day ago | 10:05 |
| Brainstorm | New from StatNews: Opinion: Empower primary care with adequate payments and technology: Primary care is struggling. Practices lost an estimated $15 billion in 2020 and fully one-third reported not having recovered financially from the pandemic. → https://www.statnews.com/2022/07/14/empower-primary-care-with-adequate-payments-and-technology/ | 10:46 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Show us Geert: B1 B cell IgM (innate antibodies) binding to SARS-COV-2 Spike, that this matters, and that it is better than an adaptive response specifically developed for these pathogens.Your "hypothesis" has no basis in data or reality. You are a danger to [... want %more?] → https://twitter.com/Marc_Veld/status/1547507986553356289 | 11:15 |
| Brainstorm | New from BMJ: Long covid and apheresis: a miracle cure sold on a hypothesis of hope: In desperate times, even in good times, we all need hope. Hope is essential and helps us seek solutions. Yet hope can be a dangerous weapon. Boris Johnson’s greatest attribute was to sell hope,... → http://www.bmj.com/content/378/bmj.o1733.short | 11:34 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): Spikevax (previously COVID-19 Vaccine Moderna), elasomeran,COVID-19 mRNA vaccine (nucleoside-modified), COVID-19 virus infection, Date of authorisation: 06/01/2021, Revision: 24, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/spikevax | 11:53 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): COVID-19 Vaccine (inactivated, adjuvanted) Valneva, COVID-19 vaccine (inactivated, adjuvanted, adsorbed), COVID-19 virus infection, Date of authorisation: [... want %more?] → https://www.ema.europa.eu/en/medicines/human/EPAR/covid-19-vaccine-inactivated-adjuvanted-valneva | 12:03 |
| Brainstorm | Updates for Russia: +4238 cases, +43 deaths since 23 hours ago — Poland: +1840 cases, +4 deaths since a day ago — Latvia: +1107 cases, +3488 tests since 23 hours ago | 12:10 |
| Brainstorm | New from EMA: What's new: Medicine: Human medicines European public assessment report (EPAR): Nuvaxovid, COVID-19 Vaccine (recombinant, adjuvanted), COVID-19 virus infection, Date of authorisation: 20/12/2021, Revision: 3, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/nuvaxovid | 12:12 |
| Brainstorm | New from BMJ: Tom Nolan’s research reviews—7 July 2022: Made to measureAll laboratory reports should come with error bars. The true value of many commonly used blood tests, such as vitamin D and HbA1c, can vary considerably from what you see when... → http://www.bmj.com/content/378/bmj.o1711.short | 12:22 |
| Brainstorm | New from Politico: EU watchdog: Failure to find VDL-Pfizer texts is ‘wake-up call”: The European Ombudsman issued recommendations for preserving texts after so-called "Delete-gate." → https://www.politico.eu/article/eu-watchdog-european-ombudsman-emily-oreilly-failure-to-find-vdl-pfizer-texts-is-wake-up-call/ | 12:51 |
| Brainstorm | New from ECDC: ECDC: Data for the maps in support of the Council Recommendation on a coordinated approach to the restriction of free movement in response to the COVID-19 pandemic in the EU/EEA → https://www.ecdc.europa.eu/en/publications-data/indicators-maps-support-council-recommendation | 13:11 |
| Brainstorm | Updates for Croatia: +1763 cases, +5 deaths, +4617 tests since 21 hours ago — Qatar: +1027 cases since 23 hours ago — Saudi Arabia: +586 cases, +3 deaths since 21 hours ago — Bosnia and Herz.: +287 cases, +2 deaths, +1035 tests since 22 hours ago | 14:02 |
| Brainstorm | New from Reddit (test): 14/07/22 - ZOE COVID-19 Study Update: 4,506,460 people are currently predicted to have symptomatic COVID-19 in the UK, up by 61,402. Yesterday was 4,445,058 (+1%) and last Thursday was 3,947,736 (+14%). → https://old.reddit.com/r/CoronavirusUK/comments/vyujsm/140722_zoe_covid19_study_update/ | 14:37 |
| Brainstorm | New from Reddit (test): nCoV: Past Covid infection does little to protect against new variant, warns Dr Anthony Fauci | 13JUL22 → https://old.reddit.com/r/nCoV/comments/vyv77u/past_covid_infection_does_little_to_protect/ | 14:57 |
| Brainstorm | Updates for Iran: +5234 cases, +8 deaths since 22 hours ago — Philippines: +2368 cases, +1 deaths, +24785 tests since 23 hours ago — UAE: +1500 cases, +241098 tests since a day ago — Fiji: +308 cases, +4199 tests since 2 days ago | 15:05 |
| Brainstorm | New from r/COVID19: COVID19: Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope → https://old.reddit.com/r/COVID19/comments/vyvi2j/emergence_of_immune_escape_at_dominant_sarscov2/ | 15:16 |
| Brainstorm | New from StatNews: Pharma: STAT+: Pharmalittle: Teva asks U.S. Supreme Court to review skinny labeling; European Commission rebuked for Pfizer texts → https://www.statnews.com/pharmalot/2022/07/14/covid19-vaccines-opioids-abortion-cancer-monkeypox-pfizer-endo-teva/ | 15:26 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The focus of immune escape vs #SARSCoV2 has been on neutralizing antibodies. Now there's evidence of CD8 T cell escape w/ a P272L mutation in the spike protein cell.com/cell/fulltext/…New @CellCellPress pic.twitter.com/EilcfEz0NI → https://twitter.com/EricTopol/status/1547580750488170498 | 16:04 |
| Brainstorm | Updates for Hong Kong: +3674 cases, +5 deaths since a day ago | 16:07 |
| Brainstorm | New from EMA: Human medicine assessment reports: (news): Human medicines European public assessment report (EPAR): M-M-RVaxPro, measles, mumps and rubella vaccine (live), Rubella;Mumps;Immunization;Measles, Date of authorisation: 05/05/2006, Revision: 30, Status: Authorised → https://www.ema.europa.eu/en/medicines/human/EPAR/m-m-rvaxpro | 16:43 |
| Brainstorm | New from LitCovid: Audio Interview: Covid-19 Vaccines and the FDA.: {'title': '', 'date': '2022-07-14T12:00:00Z', '_id': '35830648'} → https://www.ncbi.nlm.nih.gov/research/coronavirus/publication/35830648 | 17:02 |
| Brainstorm | Updates for North Macedonia: +494 cases, +1365 tests since 22 hours ago | 17:10 |
| LjL | our government is probably collapsing | 17:19 |
| ublx | join the club | 17:41 |
| Brainstorm | Updates for Kosovo: +871 cases since 23 hours ago | 18:06 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): Multiple studies have reinforced the importance for seniors to get boosted for reduction of mortality and hospitalization vs Omicron. Here's new immunologic data that backs that up @NatureMicrobiol nature.com/articles/s4156… pic.twitter.com/5hZEEELdFV → https://twitter.com/EricTopol/status/1547613872449732608 | 18:12 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Neutralizing antibody activity against 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2Yes, with weaker immunity is boosting required: it will offer broader protection against all variants. nature.com/articles/s4156… → https://twitter.com/Marc_Veld/status/1547616224141422595 | 18:23 |
| Brainstorm | New from COVID on Twitter: Marc Veldhoen (@Marc_Veld): Incidence, risk factors, natural history, and hypothesised mechanisms of myocarditis and pericarditis following covid-19 vaccination: living evidence syntheses and reviewLarge metaanalysis. bmj.com/content/378/bm… → https://twitter.com/Marc_Veld/status/1547617941427871745 | 18:33 |
| Brainstorm | New from r/COVID19: COVID19: IgG N-glycome changes during the course of severe COVID-19: An observational study → https://old.reddit.com/r/COVID19/comments/vz05k6/igg_nglycome_changes_during_the_course_of_severe/ | 18:42 |
| LjL | Draghi resigns | 18:46 |
| Brainstorm | Updates for Italy: +108632 cases, +105 deaths since a day ago | 19:08 |
| Brainstorm | New from r/COVID19: COVID19: An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females → https://old.reddit.com/r/COVID19/comments/vz1osk/an_exploratory_analysis_of_the_response_to/ | 19:48 |
| Brainstorm | Updates for Japan: +94794 cases, +30 deaths since 12 hours ago — Chile: +9698 cases, +71 deaths, +61085 tests since a day ago — Malaysia: +4098 cases since a day ago — Serbia: +2218 cases, +4 deaths, +20481 tests since a day ago | 20:05 |
| Brainstorm | New from COVID on Twitter: Gitte Pedersen (@DNABARCODE): "How Long Does #Covid #Immunity Last? Will a Second Illness Be Worse? How Can I Prepare?"#Pandemic #Coronavirus #Vaccine #Variant@AmeshAA @Laith_AbuRaddad @profshanecrotty bit.ly/3yA6o7s → https://twitter.com/DNABARCODE/status/1547644384023171075 | 20:49 |
| Brainstorm | New from COVID on Twitter: Michael Lin, MD PhD (@michaelzlin): Typical summer break: submitted 3 papers in the last 3 weeks:• SARSCoV2 protease inhibitors that work on Paxlovid-resistant mutants • Whole-body imaging of target engagement by kinase inhibitors• Luciferase substrates for brain imaging [... want %more?] → https://twitter.com/michaelzlin/status/1547658221107625986 | 21:08 |
| de-facto | %title https://onlinelibrary.wiley.com/doi/10.1002/jmv.27996 | 21:18 |
| Brainstorm | de-facto, the URL could not be loaded | 21:18 |
| Brainstorm | New from COVID on Twitter: Eric Topol (@EricTopol): The #SARSCoV2 infection imprinting problemscience.org/doi/10.1126/sc…new @ScienceMagazine by @BoytonRosemary @Daltmann10 @imperialcollege and colleagues pic.twitter.com/fZYaTcWYv2 → https://twitter.com/EricTopol/status/1547660687190532103 | 21:19 |
| Brainstorm | New from CIDRAP: News Scan for Jul 14, 2022: Impact of long COVID on workforce More backyard poultry Salmonella Unknown hemorrhagic fever in Tanzania → https://www.cidrap.umn.edu/news-perspective/2022/07/news-scan-jul-14-2022 | 21:29 |
| -Bridgestorm- 🌎 Temblor! Sismo! Earthquake! 5.5 Mb tremor, registered by 4 agencies, with 68 reports, 7 early, occurred 15 minutes ago (19:17:00 UTC), during daytime, Irapa, Venezuela (10.53, -62.64) ± 12 km likely felt 400 km away by 100 people (Twitter) | 21:32 | |
| Brainstorm | Updates for Georgia: +5154 cases since 9 days ago — Tanzania: +1336 cases since 3 days ago | 22:03 |
| Brainstorm | New from COVID on Twitter: Dalan Bailey (@Morbillivirus): Absolutely delighted that our #Covid_19 paper is finally out in @NatureMicrobiol. Our #SarsCoV2 neutralisation 'Magnus Opus'. Big big tip of the hat to the two first authors @pizza_regret @The1stNazerick nature.com/articles/s4156… → https://twitter.com/Morbillivirus/status/1547671840805359617 | 22:09 |
| Brainstorm | New from r/COVID19: COVID19: COVID-19 vaccine hesitancy amongst healthcare workers: An assessment of its magnitude and determinants during the initial phase of national vaccine deployment in Nigeria → https://old.reddit.com/r/COVID19/comments/vz4xyx/covid19_vaccine_hesitancy_amongst_healthcare/ | 22:20 |
| Brainstorm | New from CIDRAP: FDA green-lights Novavax vaccine as COVID-19 levels rise: Lisa Schnirring | News Editor | CIDRAP News Jul 14, 2022 CDC advisers meet next week to vote on whether to recommend the vaccine. → https://www.cidrap.umn.edu/news-perspective/2022/07/fda-green-lights-novavax-vaccine-covid-19-levels-rise | 22:39 |
| Timvde | LjL: our government is constantly collapsing, but we have five more, so it's fine :) | 22:40 |
| Brainstorm | New from Reddit (test): Covid2019: BA.5 symptoms: Is loss of smell more common? Anecdotally, doctors say they're seeing more Covid patients who have lost their sense of smell as the BA5 omicron subvariant takes hold. → https://old.reddit.com/r/Covid2019/comments/vz5y37/ba5_symptoms_is_loss_of_smell_more_common/ | 22:48 |
| Brainstorm | New from Reddit (test): CoronaVirus_2019_nCoV: Covid reinfections are here to stay as BA.5 cases rise: doesn’t mean people should give up on all efforts to prevent them; staying up to date on vaccinations and wearing masks indoors in places with high [... want %more?] → https://old.reddit.com/r/CoronaVirus_2019_nCoV/comments/vz6002/covid_reinfections_are_here_to_stay_as_ba5_cases/ | 22:58 |
| Brainstorm | New from COVID on Twitter: Tom Wenseleers (@TWenseleers): Well done Oxford/AstraZeneca & Pfizer/BioNTech : a tie for both in terms of nr of lives they saved! Over 12 million between the two of them according to this study... twitter.com/TheEconomist/s… → https://twitter.com/TWenseleers/status/1547690935097536513 | 23:19 |
| Brainstorm | New from Reddit (test): Covid2019: Speeding up the search for the next COVID-19 antiviral: , one team describes a new approach to identifying molecules that interfere with this protein, a step toward development of pan-coronavirus antivirals. - American Chemical Society → https://old.reddit.com/r/Covid2019/comments/vz7cbl/speeding_up_the_search_for_the_next_covid19/ | 23:49 |
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